Liebl M., Hofmann T. (2019) Cell Fate Regulation upon DNA Damage: p53 Serine 46 Kinases pave the cell death road, Bioessays, 41, 1900127


Liebl M., Hofmann T. (2019) Identification of responders to immune checkpoint therapy: which biomarkers have the highest value? European Academy of Dermatology and Venereology (JEADV), 33 (Suppl. 8), 52-56


Kaina B. (2019) Temozolomide in Glioblastoma Therapy: Role of Apoptosis, Senescence and Autophagy. Comment on Strobel et al., Temozolomide and other alkylating agents in glioblastoma therapy. Biomedicines, MDPI, 2019, 7, 69


Kress J., Di Dio L., Heck L., Pulliero A., Izzoti A., Laarmann K., Fritz G., Kaina B. (2019) Human primary endothelial cells are impaired in nucleotide excision repair and sensitive to benzo[a]pyrene compared with smooth muscle cells and pericytes, Scientific Reports, 9:13800


Christmann M., Kaina B. (2019) Epigenetic regulation of DNA repair genes and implications for tumor therapy, Mutation Research Reviews in Mutation Research (Pdf , 1,1 MB) , vol.780, 15-28


Kraus A., Mc Keague M., Seiwert N., Nagel G., Geisen S.M., Ziegler N., Trantakis I.A., Kaina B, Thomas A.D., Sturla S.J., Fahrer J. (2019) Immunological and mass spectrometry-based approaches to determine thresholds of the mutagenic DNA adduct O6-methylguanine in vivo, Archives of Toxicology, i93:559-572


Neitzel C., Seiwert N., Göder A., Diehl E., Weber C., Nagel G., Stroh S., Rasenberger B., Christmann M., Fahrer J. (2019) Lipoic Acid Synergizes with Antineoplastic Drugs in Colorectal Cancer by Targeting p53 for Proteasomal Degradation. Cells, 8(8).pii: E794. doi:10.3390/cells8080794


Rund K.M., Heylmann D., Seiwert N., Wecklein S., Oger C., Galano J.M., Durand T., Chen R., Gueler F., Fahrer J., Bornhorst J., Schebb N.H. (2019) Formation of trans-epoxy fatty acids correlates with formation of isoprostanes and could serve as biomarker of oxidative stress. Prostaglandins Other Lipid Mediat., doi: 10.1016/j.prostaglandins.2019.04.004. [Epub ahead of print]


Tomicic M.T., Steigerwald C., Rasenberger B., Brozovic A., Christmann M. (2019) Functional mismatch repair and inactive p53 drive sensitization of colorectal cancer cells to irinotecan via the IAP antagonist BV6, Archives of Toxicology, vol.93, issue 8, 2265-2277


Guo H., Treude F., Krämer O., Lüscher B., Hartkamp J. (2019) PAR-4 overcomes chemoresistance in breast cancer cells by antagonizing cIAP1, Scientific Reports, 9:8755, doi.org/10.1038/s41598-019-45209-9


Kitsera N., Rodriguez-Alvarez M., Emmert S., Carell T., Khobta A. (2019) Nucleotide excision repair of abasic DNA lesions, Nucleic Acids Research, 1-12, doi: 10.1093/narlgkz558


Kaina B., Christmann M. (2019) DNA repair in personalized brain cancer therapy with temozolomide and nitrosoureas, DNA Repair, 78, 128-141


He Y., Kaina B. (2019) Are there thresholds in glioblastoma cell death responses triggered by temozolomide? International Journal of Molecular Sciences, 20 (7), 1562


He Y., Roos W., Wu Q., Hofmann T., Kaina B. (2019) The SIAH1-HIPK2 -p53ser46 damage Response pathway in temozolomide-induced glioblastoma cell death, Molecular Cancer Research, DOI: 10.1158/1541-7786. MCR-18-1306


Gogiraju R., Hubert A., Fahrer J., Straub B.K., Brandt M., Wenzel P., Münzel T., Konstantinides S., Hasenfuss G., Schäfer K. (2019) Endothelial leptin receptor deletion promotes cardiac autophagy and angiogenesis following pressure overload by suppressing Akt/mTOR Signaling, Circulation: Heart Failure, 12:e005622


Aasland D., Götzinger L., Hauck L., Berte N., Meyer J., Effenberger M., Schneider S., Reuber E., Roos W., Tomicic M., Kaina B., Christmann M. (2019) Temozolomide induces senescence and Repression of DNA repair pathways in glioblastoma cells via activation of ATR-CHK1, p21, and NF-kB, Cancer Research, DOI: 10.1158/0008-5472.CAN-18-1733


Laarmann K., Kress J., Kaina B., Fritz G. (2019) Werner Syndrome (WRN) helicase and base excision repair (BER) factors maintain endothelial homeostasis, DNA Repair, 73, 17-27


Ponath V., Heylmann D., Haak T., Woods K., Becker H., Kaina B. (2019) Compromised DNA repair and signalling in human granulocytes, Journal of Innate Immunity, 11: 74:85


Wenz C., Faust D., Linz B., Turmann C., Nikolova T., Dietrich C. (2019) Cell-cell contacts protect against t-BuOOH-induced cellular damage and ferroptosis in vitro, Archives of Toxicology,93, 1265-1279




Institut für Toxikologie
Universitätsmedizin Mainz
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D-55131 Mainz

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