Visual Universitätsmedizin Mainz

Publikationen des Institutes für Toxikologie_2020

Taubmann A., Willershausen I., Walter C., Al-Maawi S., Kaina B., Gölz L. (2020) Genotoxic and cytotoxic potential of methacrylate-based orthodontic adhesives, Clinical Oral Investigations


Seiwert N., Wecklein S., Demuth P., Hasselwander S., Kemper T.A., Schwerdtle T., Brunner T., Fahrer J. (2020) Heme oxygenase 1 protects human colonocytes against ROS formation, oxidative DNA damage and cytotoxicity induced by heme iron, but not inorganic iron, Cell Death & Disease, 11 (9), 787


Frappart P.-O., Hofmann T. (2020) Pancreatic ductal adenocarcinoma (PDAC) organoids: the shining light at the end of the tunnel for drug response prediction and personalized medicine, MDPI, Cancers, 12 (10), 2750


Kaina B., Beltzig L., Piee-Staffa A., Haas B. (2020) Cytotoxic and Senolytic effects of methadone in combination with temozolomide in glioblastoma cells, International Journal of Molecular Sciences, 21, 7006, doi: 10.3390/ijms21197006


Kaina B. (2020) A genome-wide screening for DNA repair genes: much more players than hitherto known, Signal Transduction and Targeted Therapy, 5:204


Matos-Rodrigues G.E., Tan Pedro B., Rocha-Martins M., Charlier C.F., Gomes A.L., Cabral-Miranda F., Grigaravicius P., Hofmann T.G., Frappart P-O., Martins R.A.P. (2020) Progenitor death drives retinal dysplasia and neuronal degeneration in a mouse model of Atrip-Seckel syndrome, Disease Models & Mechanisms, 1-34


Gout J., Perkhofer L., Morawe M., Arnold F., Ihle M., Biber S., Lange S., Roger E., Kraus J.M:, Stifter K., Hahn S.A., Zamperone A., Engleitner T., Müller M., Walter K., Rodriguez-Aznar E., Sainz Jr B., Hermann P.C., Hessmann E., Müller S., Azoitei N., Lechel A., Liebau S., Wagner M., Simeone D.M., Kestler H.A., Seufferlein T., Wiesmüller L., Rad R., Frappart P-O, Kleger A. (2020) Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer, BMJ Journal, 0:1-18


Gomes A.L., Matos-Rodrigues G.E., Frappart P-O., Martins R. (2020) RINT1 loss impairs retinogenesis through TRP53-mediated apoptosis, Frontiers in cell and developmental biology, vol.8, article 711, doi:10.3389/fcell.2020.00711


Göder A., Ginter T., Kröhnert U., Kosan C., Krämer O.H. (2020) Impact of the STAT1 N-terminal domain for fibrosarcoma cell responses to gama-irradiation, Experimental Results, 1, e20, 1-9, Cambridge University Press


Volcic M., Sparrer K.M.J., Koepke  L., Hotter D., Sauter D., Stürzel C.M., Scherer M., Stamminger T., Hofmann T.G., Arhel N.J., Wiesmüller L., Kirchhoff F. (2020) Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1, Nature Microbiology,


Kaina B. (2020) Woher kommt SARS-CoV-2? Bekanntes, Unbekanntes und Überlegungen zur Herkunft des Virus, Naturwissenschaftliche Rundschau (Pdf , 10,6 MB), 864 (6), 285-296


Friedrich A., Assmann A.-S., Schumacher L., Stuijvenberg J.v., Kassack M.U., Schulz W.A., Roos W.P., Hansen F.K., Pflieger M., Kurz T., Fritz G. (2020) In vitro assessment of the genotoxic hazard of novel hydroxamic acid- and benzamide-type histone deacetylase inhibitors (HDACi), MDPI International Journal of Molecular Sciences, 21, 4747, doi: 10.3390/ijms21134747


Rodriguez-Alvarez M., Kim D., Khobta A. (2020) EGFP reporters for direct and sensitive detection of mutagenic bypass of DNA lesions, MDPI Biomolecules, 10, 902, DOI: 10.3390/biom10060902


Seiwert N., Fahrer J., Nagel G., Frank J., Behnam D., Kaina B. (2020) Curcumin administered as micellar solution suppresses intestinal inflammation and colorectal carcinogenesis, Nutrition and Cancer,  29, 1-8


Sellmer A., Pilsl B., Beyer M., Pongratz H., Wirth L., Elz S., Dove S., Henninger S.J., Spiekermann K., Polzer H., Klaeger S., Kuster B., Böhmer F.D., Fiebig H-H., Krämer O.H., Mahboobi S (2020) A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia, European Journal of Medicinal Chemistry, 193, 112232


Ziegler V., Deußen M., Schumacher L., Roos WP., Fritz G (2020) Anticancer drug and ionizing radiation-induced DNA damage differently influences transcription activity and DDR-related stress responses of an endothelial monolayer. Molecular Cell Research, volume 1867, issue 6, 118678


Seiwert N., Heylmann D., Hasselwander S., Fahrer J. (2020) Mechanism of colorectal carcinogenesis triggered by heme iron from red meat. Biochim Biophys Acta Rev. Cancer, 26: 188334


Beyer M., Romanski A., Mustafa Al-Hassan M., Pons M., Büchler I., Vogel A., Pautz A., Sellmer A., Schneider G., Bug G., Krämer O.H. (2020) HDAC3 Activity is Essential for Human Leukemic Cell Growth and the Expression of B-catenin, MYC, and Wt1, MDPI Cancers 11,1436; doi:10.3390/cancers11101436


Nikolova T., Krämer O.H. (2020) Targeting DNA double-strand break repair for glioblastoma chemotherapy.  Science World Journal of Cancer Science and Therapy, 1(1), 1-4


Kiweler N., Wünsch D., Wirth M., Mahendrarajah N., Schneider G., Stauber R.H., Brenner W., Butter F., Krämer O.H. (2020) Histone deacetylase inhibitors dysregulate DNA repair proteins and antagonize metastasis-associated processes. Journal of Cancer Research and Clinical Oncology,