Research Group Schmidt – Genomics and Applied Bioinformatics

Background

We use genomic data to resolve how viruses change, spread, and function under real-world conditions. This includes within-host evolution during prolonged infections, transmission dynamics in clinical and environmental settings, and the interpretation of viral genetic variation in a functional context.

 

Dr. Hanno Schmidt is an active member of:

Projects

Selected Publications

  1. Schmidt H, Schick L, Podlech J, Renzaho A, Lieb B, Diederich S, Hankeln T, Plachter B, Kriege O. "Adaptive Evolution of Sars-Cov-2 During a Persistent Infection for 521 Days in an Immunocompromised Patient." npj Genomic Medicine 10 (2025): 4. https://doi.org/10.1038/s41525-025-00463-x

  2. Penner I, Krämer N, Hirsch J, Büscher N, Schmidt H, Plachter B. "Deletion of the Human Cytomegalovirus Us2 to Us11 Gene Family Members Impairs the Type-I Interferon Response." Viruses 17 (2025): 426. https://doi.org/10.3390/v17030426

  3. Büscher N, Sinzger C, Lehmann C, Zimmermann C, Schmidt H, Plachter B. "Mutation of the Nuclear Localization Signals of the Major Tegument Protein Pp65 Leads to Impairment of Human Cytomegalovirus Progeny Production." Journal of General Virology 106 (2025): 002167. https://doi.org/10.1099/jgv.0.002167

  4. Schmidt H, Lemmermann N, Linke M, Bikár S-E, Runkel S, Schweiger-Seemann S, Gerber S, Michel A, Hankeln T, Veith M, Kohnen W, Plachter B. "Sars-Cov-2 Surveillance in a Hospital and Control of an Outbreak on a Geriatric Ward Using Whole Genome Sequencing." Infection Prevention in Practice 6 (2024): 100383. https://doi.org/10.1016/j.infpip.2024.100383

  5. Hewel C, Schmidt H, Runkel S, Kohnen W, Schweiger-Seemann S, Michel A, Bikar S-E, Lieb B, Plachter B, Hankeln T, Linke M, Gerber S. "Nanopore Adaptive Sampling of a Metagenomic Sample Derived from a Human Monkeypox Case." Journal of Medical Virology 96 (2024): e29610. https://doi.org/10.1002/jmv.29610

  6. Schmidt H, Mauer K, Hankeln T, Herlyn H. "Host-dependent impairment of parasite development and reproduction in the acanthocephalan model." Cell & Bioscience 12 (2022): 75. https://doi.org/10.1186/s13578-022-00818-2

  7. Schmidt H, Collier TC, Hanemaaijer MJ, Houston PD, Lee Y, Lanzaro GC. "Abundance of conserved CRISPR-Cas9 target sites within the highly polymorphic genomes of Anopheles and Aedes mosquitoes." Nature Communications 11 (2020): 1425. https://doi.org/10.1038/s41467-020-15204-0

  8. Carballar-Lejarazú R, Ogaugwu C, Tushar T, Kelsey A, Pham TB, Murphy J, Schmidt H, Lee Y, Lanzaro GC, James AA. "Next-generation gene drive for population modification of the malaria vector mosquito, Anopheles gambiae." PNAS 117 (2020): 22805-22814. https://doi.org/10.1073/pnas.2010214117

  9. Li M, Yang T, Kandul NP, Bui M, Gamez S, Raban R, Bennett J, Sánchez HM, Lanzaro GC, Schmidt H, Lee Y, Marshall JM, Akbari OS. "Development of a confinable gene drive system in the human disease vector Aedes aegypti." eLife 9 (2020): e51701. https://doi.org/10.7554/eLife.51701

  10. Fang X, Nevo E, (...) Schmidt H, (...), Wang J. "Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax." Nature Communications 5 (2014): 3966. https://doi.org/10.1038/ncomms4966

Other publications by Dr. Hanno Schmidt

Members

Dr. rer. nat. Hanno Schmidt

Dr. rer. nat. Hanno Schmidt

Sequenzierung und Bioinformatik

Collaboration partner

 

Internal (University Medical Center Mainz, Germany)

External