Genomics and applied bioinformatics (Schmidt Laboratory)
We use genomic data to resolve how viruses change, spread, and function under real-world conditions. This includes within-host evolution during prolonged infections, transmission dynamics in clinical and environmental settings, and the interpretation of viral genetic variation in a functional context.
Members
Hanno Schmidt is also member of the Genome Sequencing Consortium Mainz.
Selected Publications
Schmidt, Hanno, Lea Schick, Jürgen Podlech, Angélique Renzaho, Bettina Lieb, Stefan Diederich, Thomas Hankeln, Bodo Plachter, and Oliver Kriege. "Adaptive Evolution of Sars-Cov-2 During a Persistent Infection for 521 Days in an Immunocompromised Patient." npj Genomic Medicine 10 (2025): 4.
Penner, Inessa, Nadine Krämer, Julia Hirsch, Nicole Büscher, Hanno Schmidt, and Bodo Plachter. "Deletion of the Human Cytomegalovirus Us2 to Us11 Gene Family Members Impairs the Type-I Interferon Response." Viruses 17, no. 3 (2025): 426.
Büscher, Nicole, Christian Sinzger, Caroline Lehmann, Christine Zimmermann, Hanno Schmidt, and Bodo Plachter. "Mutation of the Nuclear Localization Signals of the Major Tegument Protein Pp65 Leads to Impairment of Human Cytomegalovirus Progeny Production." Journal of General Virology 106, no. 10 (2025): 002167.
Schmidt, Hanno, Niels Lemmermann, Matthias Linke, Sven-Ernö Bikár, Stefan Runkel, Susann Schweiger-Seemann, Susanne Gerber, et al. "Sars-Cov-2 Surveillance in a Hospital and Control of an Outbreak on a Geriatric Ward Using Whole Genome Sequencing." Infection Prevention in Practice 6, no. 3 (2024): 100383.
Hewel, Charlotte, Hanno Schmidt, Stefan Runkel, Wolfgang Kohnen, Susann Schweiger-Seemann, André Michel, Sven-Ernö Bikar, et al. "Nanopore Adaptive Sampling of a Metagenomic Sample Derived from a Human Monkeypox Case." Journal of Medical Virology 96, no. 5 (2024): e29610.
Schmidt, Hanno, and Bodo Plachter. "Virologische Grundlagen Und Varianten-Surveillance Per Genomsequenzierung." In Corona Und Arbeit - Arbeits- Und Sozialmedizinische Aspekte Zu Covid-19 Und Post-Covid, edited by Albert Nienhaus, Stephan Letzel and Dennis Nowak. Landsberg am Lech, Germany: ecomed-Storck GmbH, 2023.
More publications at HS's ORCiD profile:
