Univ.-Prof. Dr. rer. nat. Stefan Tenzer

General Information

E-Mail

 tenzer@uni-mainz.de

Current position

W2-Professor for Quantitative Proteomics
Head of Mass Spectrometry Core Facility

 

Academic Education

1999 - 2000

• Diploma Thesis Biochemistry, Eberhard-Karls-University of Tübingen, Prof. Dr. H.-G. Rammensee

1997 - 1998

• Molecular and Cellular Biology, University of Massachusetts, Amherst, USA

1994 - 2000

• Study of Biochemistry Eberhard-Karls-University of Tübingen

 

Scientific Degrees

PhD thesis

• Dr. rer. nat. (2004) at the Institute of Cell Biology, Department of Immunology under the supervision of Prof. Dr. H.-G. Rammensee

 

 

Professional Career

2016 - present

• W2 Professor "Quantitative Proteomanalytik" at the University Medical Centre of the Johannes Gutenberg University Mainz

2012 - present

• Head of the ProTIC Unit of the "Forschungszentrum Translationale Neurowissenschaften" (FTN) at the Johannes Gutenberg University Mainz

2009 - present

• Head of the Core Facility for Mass Spectrometry and Protein Biochemistry of the "Forschungszentrum für Immuntherapie" (FZI) at the Johannes Gutenberg University Mainz

2005 - present

• Group Leader for Antigen Processing and Mass Spectrometry at the Institute for Immunology, Johannes Gutenberg University Mainz

2005 - 2008

• Head of the Core Facility for Mass Spectrometry and Protein Biochemistry of the Immunology Cluster of Excellence "Immunointervention" at the Johannes Gutenberg University Mainz

2004 - 2011

• Principal investigator in the DFG Collaborative Research Center 490 "Invasion and Persistence of Infectious Pathogens" at the Johannes Gutenberg University Mainz

2004 - 2005

• Postdoctoral Fellow, Institute for Immunology, Johannes Gutenberg University Mainz, Group of Prof. Hansjörg Schild

 

Honours and Other Activities

2011

• NMFZ Forschungspreis

2007

• Boehringer Ingelheim Forschungspreis

1997

• Fulbright-Travel Grant

 

Selected Publications

1. Navarro P, Kuharev J, Gillet LC, Bernhardt OM, MacLean B, Röst HL, Tate SA, Tsou CC, Reiter L, Distler U, Rosenberger G, Perez-Riverol Y, Nesvizhskii AI, Aebersold R, Tenzer S. 2016. A multicenter study benchmarks software tools for label-free proteome quantification. Nat Biotechnol. 34(11):1130-1136.

 

2. Distler U, Kuharev J, Navarro P, Tenzer S. 2016. Label-free quantification in ion mobility-enhanced data-independent acquisition proteomics. Nat Protoc. 11(4):795-812.

 

3. Tenzer S, Leidinger P, Backes C, Huwer H, Hildebrandt A, Lenhof HP, Wesse T, Franke A, Meese E, Keller A. 2016. Integrated quantitative proteomic and transcriptomic analysis of lung tumor and control tissue: a lung cancer showcase. Oncotarget. 22;7(12):14857-70.

 

4. Distler U, Kuharev J, Navarro P, Levin Y, Schild H, Tenzer S. 2014. Drift time-specific collision energies enable deep-coverage data-independent acquisition proteomics. Nat Methods. 11(2):167-70.

 

5. Tenzer S, Crawford H, Pymm P, Gifford R, Sreenu VB, Weimershaus M, de Oliveira T, Burgevin A, Gerstoft J, Akkad N, Lunn D, Fugger L, Bell J, Schild H, van Endert P, Iversen AK. 2014. HIV-1 adaptation to antigen processing results in population-level immune evasion and affects subtype diversification. Cell Rep. 7(2):448-63.

 

6. Tenzer S*, Docter D, Kuharev J, Musyanovych A, Fetz V, Hecht R, Schlenk F, Fischer D, Kiouptsi K, Reinhardt C, Landfester K, Schild H, Maskos M, Knauer SK, Stauber RH*. 2013. Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology. Nat Nanotechnol. 8(10):772-81. *corresponding authors

 

7. Adamopoulou E, Tenzer S, Hillen N, Klug P, Rota IA, Tietz S, Gebhardt M, Stevanovic S, Schild H, Tolosa E, Melms A, Stoeckle C. 2013. Exploring the MHC-peptide matrix of central tolerance in the human thymus. Nat Commun. 4:2039.

 

8. Günther C, Martini E, Wittkopf N, Amann K, Weigmann B, Neumann H, Waldner MJ, Hedrick SM, Tenzer S, Neurath MF, Becker C. 2011. Caspase-8 regulates TNF-α-induced epithelial necroptosis and terminal ileitis. Nature. 477(7364):335-9.

 

9. Tenzer S, Wee E, Burgevin A, Stewart-Jones G, Friis L, Lamberth K, Chang CH, Harndahl M, Weimershaus M, Gerstoft J, Akkad N, Klenerman P, Fugger L, Jones EY, McMichael AJ, Buus S, Schild H, van Endert P, Iversen AK. 2009. Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance. Nat Immunol. 10(6):636-46.

 

10. Reineke J*, Tenzer S*, Rupnik M, Koschinski A, Hasselmayer O, Schrattenholz A, Schild H, von Eichel-Streiber C. 2007. Autocatalytic cleavage of Clostridium difficile toxin B. Nature. 446(7134):415-9. *contributed equally