Arbeitsgruppe Dr. Shahneh

Welcome to our dynamic research group in the Department of Dermatology, where we focus on exploring the intriguing field of monocyte and macrophage reprogramming, specifically in the context of chronic inflammatory diseases such as recurrent thrombosis and psoriasis. Our primary goal is to investigate the molecular mechanisms that underlie monocyte reprogramming, which includes identifying key signaling pathways and molecules, as well as understanding the interplay between monocyte reprogramming and immune cell function, particularly regulatory T cells.

At our lab, we employ a multidisciplinary approach that combines cutting-edge techniques in flow cytometry, RNA sequencing, Seahorse metabolic analysis, and advanced imaging techniques to understand how changes in monocyte metabolism and associated epigenetic modifications contribute to the development and progression of chronic inflammatory diseases.

Additionally, we are actively collaborating with the Center of Thrombosis and Hemostasis (CTH) and Research Center for Immunotherapy (FZI) to address complex questions related to monocyte reprogramming in thrombosis and psoriasis from different angles, including basic science, clinical research, and translational medicine. Through our collaborative, multidisciplinary approach, we aim to provide new insights into the mechanisms that drive chronic inflammation and open up new avenues for the development of effective therapies for chronic inflammatory diseases. Join us on this exciting journey as we unravel the mysteries of monocyte reprogramming and its impact on chronic inflammatory diseases.

Team

Selected Publications

1. Shahneh F, Christian Probst H, Wiesmann SC, A-Gonzalez N, Ruf W, Steinbrink K, Raker VK, Becker C. Inflammatory Monocyte Counts Determine Venous Blood Clot Formation and Resolution. Arterioscler Thromb Vasc Biol. 2022 Feb;42(2):145-155. doi: 10.1161/ATVBAHA.121.317176. Epub 2021 Dec 16. PMID: 34911360.
2. Shahneh F, Grill A, Klein M, Frauhammer F, Bopp T, Schäfer K, Raker VK, Becker C. Specialized regulatory T cells control venous blood clot resolution through SPARC. Blood. 2021 Mar 18;137(11):1517-1526. doi: 10.1182/blood.2020005407. PMID: 32932520.
3. Johann K*, Bohn T*, Shahneh F*, Luther N, Birke A, Jaurich H, Helm M, Klein M, Raker VK, Bopp T, Barz M, Becker C. Therapeutic melanoma inhibition by local micelle-mediated cyclic nucleotide repression. Nat Commun. 2021 Oct 13;12(1):5981. doi: 10.1038/s41467-021-26269-w. PMID: 34645812; PMCID: PMC8514514. (*equal contribution)
4. Haub J, Roehrig N, Uhrin P, Schabbauer G, Eulberg D, Melchior F, Shahneh F, Probst HC, Becker C, Steinbrink K, Raker VK. Intervention of Inflammatory Monocyte Activity Limits Dermal Fibrosis. J Invest Dermatol. 2019 Oct;139(10):2144-2153. doi: 10.1016/j.jid.2019.04.006. Epub 2019 Apr 27. PMID: 31039360.
5. Luther N, Shahneh F, Brähler M, Krebs F, Jäckel S, Subramaniam S, Stanger C, Schönfelder T, Kleis-Fischer B, Reinhardt C, Probst HC, Wenzel P, Schäfer K, Becker C. Innate Effector-Memory T-Cell Activation Regulates Post-Thrombotic Vein Wall Inflammation and Thrombus Resolution. Circ Res. 2016 Dec 9;119(12):1286-1295. doi: 10.1161/CIRCRESAHA.116.309301. Epub 2016 Oct 5. PMID: 27707800.

Join us

We looking for talented scientists and students. If you are interested in joining my group or need further information please do not hesitate to contact me.