Infection Immunology (Sparwasser Laboratory)

Current Research

Infectious diseases still represent a key global health problem. In Europe, lower respiratory tract infections caused for example by Streptococcus pneumoniae are a major cause of morbidity and mortality, despite the availability of vaccines against this pathogen. Additionally, the rise in infections with multi-resistant bacteria, e.g. Mycobacterium tuberculosis, represents a constant threat for our society. Under the roof of the Department of Medical Microbiology and Hygiene, researchers led by Univ.-Prof. Dr. Tim Sparwasser are investigating several key aspects of infection biology. This includes a better understanding of host-pathogen interactions and the mechanisms that activate and regulate the infection-induced immune response. In addition, they explore the genetic background and the molecular processes of infection-associated immune responses and, most importantly, they search for novel ways of modulating the immune response, which finally aims to translate the findings of this basic research into clinical applications.

Advances in modern medicine, specifically in the area of transplantation and intensive care have greatly enhanced life expectancies in western countries, but also lead to a recurrence of opportunistic (e.g. CMV and Candida) and hospital-acquired (e.g. Clostridium difficile) infections that pose serious problems to our medical system. Additional challenges of the ageing European society comprise autoimmunity and cancer. These main challenges share the common root cause of being inadequate T cell-driven immune responses.

Vaccinations are considered one of the biggest success stories in medicine and can guarantee long-term sustainability and efficiency. However, the identification of better adjuvants, particularly for T cell immunity, would address one of the largest unmet clinical needs. Novel vaccines, especially against extensively drug-resistant bacteria such as mycobacteria, remain a major challenge. A new approach rather than focusing on the pathogen itself is the concept of ‘immunomodulation’. The identification and characterization of novel microbiota-derived metabolites which directly influence the host’s immune reaction offer novel therapeutic ways to shorten chemotherapy or to reduce immunopathology in infection or inflammatory disease.

Lab Members

Univ.-Prof. Dr. med. Tim Sparwasser

Univ.-Prof. Dr. med. Tim Sparwasser

Institute Director, Principal Investigator

 Anna Fišer

Anna Fišer

Secretary

Dr. Alexandra Böttcher

Dr. Alexandra Böttcher

Scientific Manager

 Fatima Boukhallouk

Fatima Boukhallouk

Medical Technician

Platzhalter-Bild

Hitikk Chawla

HiWi, Master student

 Aleksandra Lopez Krol

Aleksandra Lopez Krol

PhD Student

Dr. Daniele Nascimento

Dr. Daniele Nascimento

Postdoc

 Monica Romero

Monica Romero

Technical assistant

PD Dr. med. Shneh Sethi

PD Dr. med. Shneh Sethi

Lecturer

 Luana Silva

Luana Silva

PhD Student

Dr. Ni Zeng

Dr. Ni Zeng

Postdoc


Year Description Awardee
2024 to date Scout of the Henriette Herz Scouting Programme, Alexander von Humboldt Foundation Prof. Dr. Tim Sparwasser
2023 Associate Professor, Cumming School of Medicine, Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Canada Prof. Dr. Katharina Lahl
2023 Lecturer/Assistant Professor, National Heart and Lung Institute, Faculty of Medicine, Imperial College, London, United Kingdom Dr. Franz Puttur
2023 Internationalization Officer, University Medical Center JGU Mainz Prof. Dr. Luciana Berod
2023 Scientific Advisory Board, NextImmune2, Luxembourg Institute of Health (LIH) Prof. Dr. Tim Sparwasser
2022 to date Personal tutor (Vertrauensdozent), Studienstiftung des deutschen Volkes (German Academic Scolarship Foundation) Prof. Dr. Tim Sparwasser
2022 to date Member of the advisory board of the Center for Research in Inflammatory Diseases (CRID), São Paulo, Brazil Prof. Dr. Tim Sparwasser
2022 Premio Leloir (Argentinian Ministry of Science, Technology and Innovation) Prof. Dr. Tim Sparwasser
2022 Call for a W3 Professorship, Institute for Medical Microbiology, JLU Gießen (declined) Prof. Dr. Tim Sparwasser
2022 Assistant Professor, İzmir Tinaztepe University, Turkey Dr. Gülhas Solmaz
2022 TransMed Scientist Award (PhD) Dr. Luís Ferreira de Almeida
2022 HBRS Award (Hannover Biomedical Research School) Dr. Luís Ferreira de Almeida
2021 Dagmar Eißner Award Ayesha Dhillon-LaBrooy
2020-2023 Member Senate Committee on Internationalization (JGU Mainz) Prof. Dr. Tim Sparwasser
2020 Call for a W2 professorship, Institute for Molecular Medicine Dr. Luciana Berod
2019 to date German representative of the International Council of Immunologists (IUIS) Prof. Dr. Tim Sparwasser
2019-2023 Member of the DGfI Advisory Board 2nd period of office Prof. Dr. Tim Sparwasser
2018 to date Member Steering committee FZI (JGU Mainz) Prof. Dr. Tim Sparwasser
2018 to date Associate Researcher Center for Research in Inflammatory Diseases – CRID Ribeirao Preto Medical School, University of Sao Paulo CRID Ribeirao Preto Medical School, University of Sao Paulo Prof. Dr. Tim Sparwasser
2018 Call for a W3 professorship / Chair Institute for Medical Microbiology and Hygiene (IMMH), JGU Mainz Prof. Dr. Tim Sparwasser
2018 Robert Koch Postoctoral Prize in Immunology Dr. Christian Thomas Mayer
2018 Early Career Research Prize in Vaccinology (IUIS) Dr. Christian Thomas Mayer
2018 MHH HILF PostDoc Research Funding Dr. Jenny Kühne
2017 Call for a W3 professorship, Institute for Medical Microbiology and Virology, TU Dresden (declined) Prof. Dr. Tim Sparwasser
2017 MHH Promotion Award Dr. Marc Lindenberg
2017 DZIF MD-PhD Scholarship Dr. Marc Lindenberg
2016-2023 Chairman DGfI Jury of Fritz -and Ursula Melcher Award Prof. Dr. Tim Sparwasser
2016-2018 Member COALITION / CIIM (MHH) Prof. Dr. Tim Sparwasser
2016 HZI Paper of the month Marcela Francoso/ Dr. Franz Puttur
2016 Lundbeck Award Dr. Katharina Lahl
2016 Jürgen-Wehland Award Dr. Luciana Berod
2016 DAAD Scholarship Dr. Lis Velasquez
2016 HZI Paper of the month Markus Dudek
2016 EMBO Scholarship Dr. Carlos Bueno
2016 DAAD Short-term Scholarship Lais Sacramento
2016 DAAD Short-term Scholarship Paulo Melo
2016 FAPESP Scholarship (Sabbatical) Prof. Dr. Vania Bonato
2015-2018 Guest professor Microbiology and Infection Immunology, Facultad de Medicina, Universidad Catolica de Cordoba, Argentina Prof. Dr. Tim Sparwasser
2015 Ellen-Schmidt Habil. Scholarship Dr. Luciana Berod
2015 Boehringer Ingelheim Foundation Lucia Minarrieta
2015 DAAD Scholarship Brenda Raud
2015 Ragnar Söderberg Fellowship in Medicine Dr. Katharina Lahl
2015 EMBO Fellowship Dr. Christian Thomas Mayer
2014-2018 Member of the DGfI Advisory Board 1st period of office Prof. Dr. Tim Sparwasser
2014-2018 Member of the International Council of Hannover Medical School Prof. Dr. Tim Sparwasser
2014 Fritz- und Ursula Melchers DGfI Postdoc award Dr. Christian Thomas Mayer
2014 Poster award/ Travel grant (Seahorse) Dr. Luciana Berod
2014 HZI Paper of the month Dr. Catharina Arnold-Schrauf
2014 HZI Paper of the month Peyman Ghorbani
2014 HZI Paper of the month Dr. Luciana Berod
2014 MHH HILF PostDoc Research Funding Dr. Luciana Berod
2013 HZI Inhoffen Award Dr. Christian Thomas Mayer
2013 MHH HILF PostDoc Research Funding Dr. Franz Puttur
2013 HZI Paper of the month Dr. Franz Puttur
2013 Ciência sem fronteiras CAPES Scholarship Marcela Francozo
2013 Fulbright Scholarship Aline Sandouk
2012 TUI Habilitation Award Dr. Matthias Lochner
2011 HZI Paper of the month Dr. Matthias Lochner
2010-2019 Advisory Board Member of GRK 1660 Prof. Dr. Tim Sparwasser
2010 Boehringer Ingelheim Foundation PhD Fellowship Catharina Arnold-Schrauf
2010 DAAD PhD Fellowship Amrita Nandan
2009-2013 Board member of the Collaborative Research Center SFB 587 Prof. Dr. Tim Sparwasser
2009 PhD Scholarship German National Academic Foundation Christian Thomas Mayer
2008 Call for a W3 professorship for Infection Immunology (TWINCORE, a joint venture between Hannover Medical School and Helmholtz Center for Infection Research), Hannover Prof. Dr. Tim Sparwasser
2007-2008 Board member of the TR 22 Prof. Dr. Tim Sparwasser
1999-2002 HHMI Postdoctoral Fellowship Award for Physicians Dr. Tim Sparwasser
1999 DGHM Young Investigator Award (German Society of Microbiology & Hygiene) Dr. Tim Sparwasser
1989-1995 Scholarship German National Academic Foundation Tim Sparwasser

Alumni

Yu-San Kao PhD at IMMH (2019-2023) with Tim Sparwasser; Postdoctoral Fellow (2023-2024), Universitätsmedizin, Johannes Gutenberg Universität Mainz 
Currently: Postdoctoral Research Associate, The Princeton Branch of the Ludwig Institute for Cancer Research, Princeton University, USA

Panagiota Mamareli PhD at TWINCORE/MHH (2013-2018) with Matthias Lochner; Postdoctoral Fellow (2019-2023), Universitätsmedizin, Johannes Gutenberg Universität Mainz 
Currently: Laboratory Head, Sanofi, Frankfurt am Main

Lucas Luján Visiting PhD Student, TransMed, Universitätsmedizin, Johannes Gutenberg Universität Mainz (2023); PhD Candidate, CONICET, Universität Cordoba, Argentinien

Cecilia Molina Visiting PhD Student, TransMed, Universitätsmedizin, Johannes Gutenberg Universität Mainz (2023); PhD Candidate, CONICET, Universität Cordoba, Argentinien

Luis Eduardo A. Damasceno Visiting PhD Student, funded by Sao Paulo Research Foundation, Universitätsmedizin, Johannes Gutenberg Universität Mainz (2022); Postdoc, Ribeirao Preto Medical School, University of Sao Paulo, Brazil

Luís P Almeida Master Thesis, Medical Biochemistry, German-Argentinean AMIBA Master Program in Infection Biology at TWINCORE/Medizinische Hochschule Hannover (MHH) (2019) currently: PhD student, Immunoparasitology with Maria Yazdanbakhsh, Leiden University Medical Center, Leiden, Netherlands

Jon Arnason DAAD scholarship as “visiting student” (2002-2003)
afterwards: Hematology Oncology Fellow at Weill Cornell Medical Center New York City
currently: MD, Beth Israel Deaconess Medical Center of Boston, USA

Catharina Arnold-Schrauf PhD scholarship holder of Boehringer Ingelheim foundation (2010-2014); PhD at TWINCORE/MHH and Postdoctoral Fellow SFB 900 (2014-2015)
afterwards: Postdoctoral Fellow, Centre d’ Immunologie de Marseille with Marc Dalod, Marseille, France
currently: Medical Affairs Specialist, Hematology/Oncology at Celgene in Vienna, Austria

Abdul Mannan Baru Postdoctoral Fellow at TWINCORE/MHH (2009-2012)
afterwards: Postdoctoral Fellow in Molecular and Translational Cardiology with Kai C. Wollert
currently: Associate Director, GlaxoSmithKline Pharma GmbH, Stevenage, United Kingdom

Luciana Berod Postdoctoral Fellow and Group leader at TWINCORE, a joint venture of MHH and Helmholtz Centre for Infection Research (HZI) (2010-2020)
currently: W2 Professor at the Institute for Molecular Medicine, Universitätsmedizin, Johannes Gutenberg University Mainz

Carla Castro Postdoctoral Fellow at TWINCORE/MHH (2013-2016)
currently: Postdoctoral Fellow, Center for Chronic Immundeficency (CCI) with Stephan Ehl, University Medical Center Freiburg

Andrea Classen Master Thesis, Biochemistry at LMU Munich (2003-2004)
recently: PhD, Macrophage Biology with Antonio Celada, Institute for Research in Biomedicine, University of Barcelona, Spain

Daniela Dittlein Bachelor Thesis, Biochemistry at TU Munich (2007); PhD at TUM
currently: Scientific Advisor to the CEO, Helmholtz Center Munich

Markus Dudek PhD scholarship holder of IRTG 1273 (2011-2016); PhD at TWINCORE/MHH
afterwards: Postdoctoral Fellow at Center for Thrombosis und Haemostasis (CTH) with Markus Bosmann, University Medical Center Mainz
currently: Scientist, Translational Biomarkers, Sanofi, Frankfurt am Main

Theresa Förg Doctoral student in Medicine at TU Munich (TUM)/TWINCORE (2009); Scholarship holder Studienstiftung des deutschen Volkes; MD at TUM
currently: Medical Specialist, Pediatric Clinic and Pediatric Polyclinic, LMU Munich

Marcela Francozo DAAD/CAPES PhD scholarship holder, PhD student (2013-2017) and Postdoctoral Fellow at TWINCORE/MHH (2018-2019)
currently: Assistant Project Manager, Vakzine Project Management GmbH, Hannover

Christin Friedrich PhD student, DFG funded, PhD at TWINCORE/MHH (2011-2014)
afterwards: Postdoctoral Fellow with Georg Gasteiger at the Johannes Gutenberg-University Mainz
currently: Postdoctoral Fellow, Institute for Systems Immunology with Georg Gasteiger, University Würzburg

Venkateswaran Ganesh PhD scholarship holder at the Molecular Medicine PhD Program (2009-2013); PhD at TWINCORE/MHH
afterwards: Research Scientist, Pfizer, Chennai, India
currently: Associate Manager, Program Management, Biocon, Bengaluru Area, India

Maria Virginia Gentilini Postdoctoral Fellow SFB 900 (2015-2016)
currently: Lecturer at the University of Buenos Aires and Postdoctoral scholarship, CONICET, University Medical Center "José de San Martín" in Buenos Aires, Argentina

Peyman Ghorbani PhD student, Center for Infectious Biology (ZIB), PhD at TWINCORE/MHH (2012-2017)
currently: Postdoctoral Fellow, University of Ottawa with Morgan Fullerton, Canada

Wiebke Ginter PhD scholarship holder of Center for Infectious Biology (ZIB) (2009-2013); PhD at TWINCORE/MHH
afterwards: Scientific coordinator of LISA Summer Academy and AMIBA Master Program
currently: Consultant Science Management, Deutsche Forschungsgemeinschaft (DFG), Bonn

Naghmeh Goharani Doctoral student in Medicine, “StrucMed” TWINCORE/MHH (2012-2014); MD at MHH

Stefanie Hagemann PhD scholarship holder KFO250 (2010-2013); PhD at TWINCORE/MHH
currently: Postdoctoral Fellow with Siegfried Hapfelmeier at Institute for Infectious diseases, University Bern, Switzerland

Andrea Hartl PhD student Biology (2004-2009) and PhD at TU Munich
currently: Team Leader Crime/Project Manager/LIMS Administrator, Eurofins Medigenomix Forensik GmbH, Ebersberg

Karen Patricia Hartmann Student assistant (2013-2014); Bachelor Thesis, Biomedicine at Leibniz University Hannover and TWINCORE (2013-2013)
afterwards: Employee at the Paul-Ehrlich-Institute in Langen, Molecular Biotechnology and Gene Therapy with Christian Buchholz
currently: PhD Student at the University of Zürich, Department of Biochemistry, Zurich, Switzerland

Siona Hauer Doctoral student in Medicine, StrucMed/MHH (2010-2011); MD at MHH

Christina Hesse PhD scholarship holder International Research Training Groups 1441 (2010-2014); PhD and Postdoctoral Fellow at TWINCORE/MHH (2015)
afterwards: Postdoctoral Fellow Fraunhofer with Armin Braun at Institute for Toxicology and Experimental Medicine (ITEM)
currently: Group leader „Respiratory Pharmcology“, Department of Preclinical Pharmacology and In Vitro Toxicology at ITEM, Hannover

Susanne Hipp Bachelor Thesis, Biochemistry at TU Munich (2004)

Julia Huntenburg Bachelor Thesis, Life Sciences at Leibnitz University Hannover and TWINCORE/MHH, Scholarship holder Studienstiftung des Deutschen Volkes (2010)
afterwards: Master Program Molecular Medicine, Charité Berlin
currently: PhD student at Max-Planck Institute for Human Cognitive and Brain Sciences, Leipzig

Inga Jensch Master Thesis, Biology at TU Munich (2004-2005); PhD Microbiology with Sven Hammerschmidt, University Greifswald
currently: Postdoctoral Fellow with Matthias Hundt at the ZIK HIKE, University of Greifswald

Stefan Jordan Master Thesis, Biochemistry at TU Munich (2006); Scholarship holder of the Studienstiftung des deutschen Volkes; PhD with Ulrich Koszinowski, Max von Pettenkofer-Institute at LMU
afterwards: Postdoctoral Fellow with Miriam Merad, New York Mount Sinai School of Medicine, USA
currently: Group leader, Institute for Microbiology and Infection Immunology, Charité Berlin

Wilhelm Korte Doctoral student in Medicine, StrucMed/MHH (2011-2012)
recently: Assistant Physician in Heart Surgery at MHH

Freyja Kull Doctoral student in Medicine, StrucMed/MHH (2013)

Katharina Lahl Diploma Thesis (2004-2005) and PhD student at TU Munich (2005-2009)
afterwards: Postdoctoral Fellow, Stanford University with Eugene Butcher, Palo Alto, USA
later: Group leader and Associate Professor, DTU Health Tech, Technical University Denmark and Divison Virus Recognition, Lund University, Sweden
currently: Associate Professor, Cumming School of Medicine, Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Canada

Marc Lindenberg MD student (2012-2013); MD/PhD at MHH (2018-2020)

Matthias Lochner Group leader, then Associate Professor (PD) at TWINCORE/MHH (2010-2020), currently Associate Professor at the Department for Medical Microbiology, MHH

Christian Mayer Master Thesis, Biochemistry at TU Munich (2007-2008), PhD scholarship holder Studienstiftung des deutschen Volkes, PhD (2008-2012) and Postdoctoral fellow at TWINCORE/MHH (2012-2013)
afterwards: Postdoctoral Fellow with Michel Nussenzweig, Rockefeller University, New York, USA
currently: NIH Stadtman Investigator at the Experimental Immunology Branch, National Cancer Institute, Bethesda, USA

Lucia Minarrieta PhD scholarship holder of Boehringer Ingelheim foundation, PhD student, Center for Infectious Biology (ZIB) at TWINCORE/MHH (2014-2018)
currently: Postdoctoral Fellow with Julie St-Pierre, University of Ottawa, Canada

Mercedes Muske Master Thesis at TWINCORE/MHH (2014-2015)

Amrita Nandan DAAD PhD scholarship holder, PhD at MHH (2010-2014)
currently: Project Scientist, Institute of Genomics and Integrative Biology (IGIB), CSIR, India

Franz Puttur Postdoctoral Fellow at TWINCORE/MHH (2010-2016)
currently: Lecturer/Assistant Professor at the Imperial College, National Heart and Lung Institute, Faculty of Medicine, in London, United Kingdom

Brenda Raud DAAD PhD scholarship holder, PhD student at TWINCORE/MHH (2014-2018)
currently: Postdoctoral Fellow with John Haanen, Division of Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands

Martin Schäfer PhD student Biology at TU Munich (2003-2006); PhD at TU Munich
currently: Research Scientist Bioanalytics, Roche Diagnostics GmbH in Penzberg

Gülhas Solmaz PhD scholarship holder of Center for Infectious Biology (ZIB) (2011-2016); PhD at TWINCORE/MHH
currently: Assistant Professor, İzmir Tinaztepe University, Turkey

Johannes Stephani Doctoral student in Medicine at TU Munich (2006-2008); MD at TU Munich
currently: Intern, Internal Medicine, University Medical Center Ulm

Philipp Stüve Master Thesis (2013) and PhD (2013-2017) at TWINCORE/MHH
later: Postdoctoral Fellow at IMMH, Universitätsmedizin, Johannes Gutenberg University Mainz
currently: Postdoctoral researcher, Leibniz Institut für Immuntherapie, Regensburg

Lena Thöle Master Thesis, Biochemistry at TWINCORE/MHH, scholarship holder Studienstiftung des deutschen Volkes (2016)
currently: Medical student at MHH

Christopher Untucht Postdoctoral Fellow (2011-2012)
afterwards: Postdoctoral Fellow at AbbVie Germany GmbH & Co KG
currently: Senior Scientist II Abbvie, Ludwigshafen

Christopher van Helt Master Thesis, Biomedicine at TWINCORE/MHH (2010)
afterwards: PhD student at Beiersdorf, Division Experimental Toxikology
currently: QA Manager Release, Sandoz, Austria

Ferdinand von Meyenn Master Thesis, Biochemistry - TU Munich (2005-2006); PhD, Institute of Molecular Systems Biology with Markus Stoffel, ETH Zurich
afterwards: Postdoctoral Fellow with Wolfgang Reik, University of Cambridge
currently: Assistant Professor, Laboratory of Nutrition and Metabolic Epigenetics, ETH Zurich, DHEST, Austria

Zuobai Wang PhD scholarship holder at the "Center for Infection Biology“ (2010-2014); PhD at TWINCORE/MHH
currently: Postdoctoral Fellow at BeiGene, Beijing, China

Vera Wenzel Bachelor Thesis -TU Munich (2007); PhD at TU Munich
currently: Medical Lead Education Solutions, coliquio


Publications

2025

Goranovič, D., Jenko, B., Ramšak, B., Podgoršek Berke, A., Bedrač, L., Horvat, J., Šala, M., Makuc, D., Carriche, G. M., Silva, L., Lopez Krol, A., Pšeničnik, A., Durán Alonso, M. B., Avbelj, M., Stavber, S., Plavec, J., Sparwasser, T., Müller, R., Kosec, G., Fujs, Š., … Petković, H. (2025). Efficient and Selective Biosynthesis of a Precursor-Directed FK506 Analogue: Paving the Way for Click Chemistry. Journal of natural products, 10.1021/acs.jnatprod.4c00394. Advance online publication. https://doi.org/10.1021/acs.jnatprod.4c00394

Stüve, P., Godoy, G. J., Ferreyra, F. N., Hellriegel, F., Boukhallouk, F., Kao, Y. S., More, T. H., Matthies, A. M., Akimova, T., Abraham, W. R., Kaever, V., Schmitz, I., Hiller, K., Lochner, M., Salomon, B. L., Beier, U. H., Rehli, M., Sparwasser, T., & Berod, L. (2025). ACC1 is a dual metabolic-epigenetic regulator of Treg stability and immune tolerance. Molecular metabolism, 94, 102111. https://doi.org/10.1016/j.molmet.2025.102111


Honours and Awards