Visual Universitätsmedizin Mainz

Infection Immunology (Sparwasser Laboratory)

Current Research

Infectious diseases still represent a key global health problem. In Europe, lower respiratory tract infections caused for example by Streptococcus pneumoniae are a major cause of morbidity and mortality, despite the availability of vaccines against this pathogen. Additionally, the rise in infections with multi-resistant bacteria, e.g. Mycobacterium tuberculosis, represents a constant threat for our society. Under the roof of the Department of Medical Microbiology and Hygiene, researchers led by Univ.-Prof. Dr. Tim Sparwasser are investigating several key aspects of infection biology. This includes a better understanding of host-pathogen interactions and the mechanisms that activate and regulate the infection-induced immune response. In addition, they explore the genetic background and the molecular processes of infection-associated immune responses and, most importantly, they search for novel ways of modulating the immune response, which finally aims to translate the findings of this basic research into clinical applications.

Advances in modern medicine, specifically in the area of transplantation and intensive care have greatly enhanced life expectancies in western countries, but also lead to a recurrence of opportunistic (e.g. CMV and Candida) and hospital-acquired (e.g. Clostridium difficile) infections that pose serious problems to our medical system. Additional challenges of the ageing European society comprise autoimmunity and cancer. These main challenges share the common root cause of being inadequate T cell-driven immune responses.

Vaccinations are considered one of the biggest success stories in medicine and can guarantee long-term sustainability and efficiency. However, the identification of better adjuvants, particularly for T cell immunity, would address one of the largest unmet clinical needs. Novel vaccines, especially against extensively drug-resistant bacteria such as mycobacteria, remain a major challenge. A new approach rather than focusing on the pathogen itself is the concept of ‘immunomodulation’. The identification and characterization of novel microbiota-derived metabolites which directly influence the host’s immune reaction offer novel therapeutic ways to shorten chemotherapy or to reduce immunopathology in infection or inflammatory disease.

Lab Members

Univ.-Prof. Dr. med. Sparwasser
Tim Sparwasser, Univ.-Prof. Dr. med.

Further Information

Dr. rer. nat. Breid
Sara Breid, Dr. rer. nat.
Position: Function: Scientific Manager

06131 17-9234;
Further Information

Dr. Almeida
Luìs Almeida, Dr.
Position: Function: Postdoc
Further Information

Fatima Boukhallouk
Position: Function: Medical Technician

06131 17-9011 office or 9082 lab
06131 17-9234
Further Information

Ayesha Dhillon-Labrooy
Position: Function: Postdoc

Yu-San Kao
Position: Function: Ph.D. Student

06131 17-9011
06131 17-9234
Further Information

Panagiota Mamareli
Position: Function: Postdoc

06131 17-9011 office or 9082 lab
06131 17-9234
Further Information

Dr. s. hum. Rampoldi
Francesca Rampoldi, Dr. s. hum.
Position: Function: Postdoc

06131 17-9137
06131 17-9234



Almeida, L., A. Dhillon-LaBrooy, G. Carriche, L. Berod, and T. Sparwasser. 2021. CD4(+) T-cell differentiation and function: Unifying glycolysis, fatty acid oxidation, polyamines NAD mitochondria. J Allergy Clin Immunol

Carriche, G.M., L. Almeida, P. Stuve, L. Velasquez, A. Dhillon-LaBrooy, U. Roy, M. Lindenberg, T. Strowig, C. Plaza-Sirvent, I. Schmitz, M. Lochner, A.K. Simon, and T. Sparwasser. 2020. Regulating T cell differentiation through the polyamine spermidine. J Allergy Clin Immunol

Almeida, L.*, A. Dhillon-LaBrooy*, C.N. Castro, N. Adossa, G.M. Carriche, M. Guderian, S. Lippens, S. Dennerlein, C. Hesse, B.N. Lambrecht, L. Berod, L. Schauser, B.R. Blazar, M. Kalesse, R. Muller, L.F. Moita, and T. Sparwasser. 2021. Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis. Immunity 54:68-83 e66. *equally contributed

Korkmaz, Y., Puladi, B., Galler, K., Kammerer, P.W., Schroder, A., Golz, L., Sparwasser, T., Bloch, W., Friebe, A., and Deschner, J. 2021. Inflammation in the Human Periodontium Induces Downregulation of the alpha1- and beta1-Subunits of the sGC in Cementoclasts. Int J Mol Sci 22.

Lindenberg, M., L. Almeida, A. Dhillon-LaBrooy, E. Siegel, B. Henriques-Normark, and T. Sparwasser. 2021. Clarithromycin impairs tissue-resident memory and Th17 responses to macrolide-resistant Streptococcus pneumoniae infections. J Mol Med (Berl)

Minarrieta, L., Velasquez, L.N., Sparwasser, T., and Berod, L. 2021. Dendritic cell metabolism: moving beyond in vitro-culture-generated paradigms. Curr Opin Biotechnol 68, 202-212.


Einwachter, H., A. Heiseke, A. Schlitzer, G. Gasteiger, H. Adler, D. Voehringer, M.G. Manz, Z. Ruzsics, L. Dolken, U.H. Koszinowski, T. Sparwasser, W. Reindl*, and S. Jordan*. 2020. The Innate Immune Response to Infection Induces Erythropoietin-Dependent Replenishment of the Dendritic Cell Compartment. Front Immunol 11:1627. *equally contributed

Gamrekelashvili, J., Kapanadze, T., Sablotny, S., Ratiu, C., Dastagir, K., Lochner, M., Karbach, S., Wenzel, P., Sitnow, A., Fleig, S., et al. (2020). Notch and TLR signaling coordinate monocyte cell fate and inflammation. Elife 9.

Haack, S., S. Baiker, J. Schlegel, M. Sauer, T. Sparwasser, D. Langenhorst, and N. Beyersdorf. 2020. Superagonistic CD28 stimulation induces Interferon gamma release from mouse T Helper 1 cells in vitro and in vivo. Eur J Immunol

Mamareli, P., F. Kruse, C.W. Lu, M. Guderian, S. Floess, K. Rox, D.S.J. Allan, J.R. Carlyle, M. Bronstrup, R. Muller, L. Berod, T. Sparwasser*, and M. Lochner*. 2020. Targeting cellular fatty acid synthesis limits T helper and innate lymphoid cell function during intestinal inflammation and infection. Mucosal Immunol. *equally contributed

Mesquita, I., C. Ferreira, D. Moreira, G.E.G. Kluck, A.M. Barbosa, E. Torrado, R.J. Dinis-Oliveira, L.G. Goncalves, C.J. Beauparlant, A. Droit, L. Berod, T. Sparwasser, N. Bodhale, B. Saha, F. Rodrigues, C. Cunha, A. Carvalho, A.G. Castro, J. Estaquier, and R. Silvestre. 2020. The Absence of HIF-1alpha Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis. Cell Rep 30:4052-4064 e4057.

Miyanaga, N.*, H. Takagi*, T. Uto, T. Fukaya, J. Nasu, T. Fukui, Y. Nishikawa, T. Sparwasser, N. Choijookhuu, Y. Hishikawa, T. Nakamura, T. Tono, and K. Sato. 2020. Essential role of submandibular lymph node dendritic cells in protective sublingual immunotherapy against murine allergy. Commun Biol 3:742.*equally contributed

Moye, S., T. Bormann, R. Maus, T. Sparwasser, I. Sandrock, I. Prinz, G. Warnecke, T. Welte, J. Gauldie, M. Kolb*, and U.A. Maus*. 2020. Regulatory T Cells Limit Pneumococcus-Induced Exacerbation of Lung Fibrosis in Mice. J Immunol 204:2429-2438. *equally contributed

Sacramento, L.A., L. Benevides, S.R. Maruyama, L. Tavares, K.F. Fukutani, M. Francozo, T. Sparwasser, F.Q. Cunha, R.P. Almeida, J.S. da Silva, and V. Carregaro. 2020. TLR4 abrogates the Th1 immune response through IRF1 and IFN-beta to prevent immunopathology during L. infantum infection. PLoS Pathog 16:e1008435.



Ahmetlic, F., T. Riedel, N. Homberg, V. Bauer, N. Trautwein, A. Geishauser, T. Sparwasser, S. Stevanovic, M. Rocken, and R. Mocikat. 2019. Regulatory T Cells in an Endogenous Mouse Lymphoma Recognize Specific Antigen Peptides and Contribute to Immune Escape. Cancer Immunol Res 7:600-608.

Al Nabhani, Z., S. Dulauroy, R. Marques, C. Cousu, S. Al Bounny, F. Dejardin, T. Sparwasser, M. Berard, N. Cerf-Bensussan, and G. Eberl. 2019. A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult. Immunity 50:1276-1288 e1275.

Andersen, L., A.F. Gulich, M. Alteneder, T. Preglej, M.J. Orola, N. Dhele, V. Stolz, A. Schebesta, P. Hamminger, A. Hladik, S. Floess, T. Krausgruber, T. Faux, S.B.A. Andrabi, J. Huehn, S. Knapp, T. Sparwasser, C. Bock, A. Laiho, L.L. Elo, O. Rasool, R. Lahesmaa, S. Sakaguchi, and W. Ellmeier. 2019. The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3(+) Regulatory T Cells. Cell Rep 29:4447-4459 e4446.

Ichikawa, T.*, K. Hirahara*, K. Kokubo*, M. Kiuchi, A. Aoki, Y. Morimoto, J. Kumagai, A. Onodera, N. Mato, D.J. Tumes, Y. Goto, K. Hagiwara, Y. Inagaki, T. Sparwasser, K. Tobe, and T. Nakayama. 2019. CD103(hi) Treg cells constrain lung fibrosis induced by CD103(lo) tissue-resident pathogenic CD4 T cells. Nat Immunol 20:1469-1480. *equally contributed

Mamareli, P., F. Kruse, C. Friedrich, N. Smit, T. Strowig, T. Sparwasser, and M. Lochner. 2019. Epithelium-specific MyD88 signaling, but not DCs or macrophages, control acute intestinal infection with Clostridium difficile. Eur J Immunol 49:747-757.

Schmidleithner, L.*, Y. Thabet*, E. Schonfeld*, M. Kohne, D. Sommer, Z. Abdullah, T. Sadlon, C. Osei-Sarpong, K. Subbaramaiah, F. Copperi, K. Haendler, T. Varga, O. Schanz, S. Bourry, K. Bassler, W. Krebs, A.E. Peters, A.K. Baumgart, M. Schneeweiss, K. Klee, S.V. Schmidt, S. Nussing, J. Sander, N. Ohkura, A. Waha, T. Sparwasser, F.T. Wunderlich, I. Forster, T. Ulas, H. Weighardt, S. Sakaguchi, A. Pfeifer, M. Bluher, A.J. Dannenberg, N. Ferreiros, L.J. Muglia, C. Wickenhauser, S.C. Barry, J.L. Schultze*, and M. Beyer*. 2019. Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction. Immunity 50:1232-1248 e1214. *equally contributed

Serradell, M.C.*, L.L. Rupil*, R.A. Martino, C.G. Prucca, P.G. Carranza, A. Saura, E.A. Fernandez, P.R. Gargantini, A.H. Tenaglia, J.P. Petiti, R.R. Tonelli, N. Reinoso-Vizcaino, J. Echenique, L. Berod, E. Piaggio, B. Bellier, T. Sparwasser, D. Klatzmann*, and H.D. Lujan*. 2019. Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins. Nat Commun 10:361. *equally contributed

Solmaz, G.*, F. Puttur*, M. Francozo, M. Lindenberg, M. Guderian, M. Swallow, V. Duhan, V. Khairnar, U. Kalinke, B. Ludewig, B.E. Clausen, H. Wagner, K.S. Lang, and T.D. Sparwasser. 2019. TLR7 Controls VSV Replication in CD169(+) SCS Macrophages and Associated Viral Neuroinvasion. Front Immunol 10:466. *equally contributed

Steel, N., A.A. Faniyi, S. Rahman, S. Swietlik, B.I. Czajkowska, B.T. Chan, A. Hardgrave, A. Steel, T.D. Sparwasser, M.B. Assas, R.K. Grencis, M.A. Travis, and J.J. Worthington. 2019. TGFbeta-activation by dendritic cells drives Th17 induction and intestinal contractility and augments the expulsion of the parasite Trichinella spiralis in mice. PLoS Pathog 15:e1007657.

Wang, Y., K. Dembowsky, E. Chevalier, P. Stuve, M. Korf-Klingebiel, M. Lochner, L.C. Napp, H. Frank, E. Brinkmann, A. Kanwischer, J. Bauersachs, M. Gyongyosi, T. Sparwasser, and K.C. Wollert. 2019. C-X-C Motif Chemokine Receptor 4 Blockade Promotes Tissue Repair After Myocardial Infarction by Enhancing Regulatory T Cell Mobilization and Immune-Regulatory Function. Circulation 139:1798-1812.



Akeus, P., L. Szeponik, F. Ahlmanner, P. Sundstrom, S. Alsen, B. Gustavsson, T. Sparwasser, S. Raghavan, and M. Quiding-Jarbrink. 2018. Regulatory T cells control endothelial chemokine production and migration of T cells into intestinal tumors of APC(min/+) mice. Cancer Immunol Immunother 67:1067-1077.

Alissafi, T.*, E. Kourepini*, D.C.M. Simoes*, N. Paschalidis, M. Aggelakopoulou, T. Sparwasser, L. Boon, H. Hammad, B.N. Lambrecht, and V. Panoutsakopoulou. 2018. Osteopontin Promotes Protective Antigenic Tolerance against Experimental Allergic Airway Disease. J Immunol 200:1270-1282. *equally contributed

Andreas, N., M. Riemann, C.N. Castro, M. Groth, I. Koliesnik, C. Engelmann, T. Sparwasser, T. Kamradt, R. Haenold, and F. Weih. 2018. A new RelB-dependent CD117(+) CD172a(+) murine DC subset preferentially induces Th2 differentiation and supports airway hyperresponses in vivo. Eur J Immunol 48:923-936.

Divakaruni, A.S.*, W.Y. Hsieh*, L. Minarrieta, T.N. Duong, K.K.O. Kim, B.R. Desousa, A.Y. Andreyev, C.E. Bowman, K. Caradonna, B.P. Dranka, D.A. Ferrick, M. Liesa, L. Stiles, G.W. Rogers, D. Braas, T.P. Ciaraldi, M.J. Wolfgang, T. Sparwasser, L. Berod, S.J. Bensinger*, and A.N. Murphy*. 2018. Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis. Cell Metab 28:490-503 e497.*equally contributed

Paul-Heng, M.*, M. Leong*, E. Cunningham, D.L.J. Bunker, K. Bremner, Z. Wang, C. Wang, S.S. Tay, C. McGuffog, G.J. Logan, I.E. Alexander, M. Hu, S.I. Alexander, T.D. Sparwasser, P. Bertolino, D.G. Bowen, G.A. Bishop, and A. Sharland. 2018. Direct recognition of hepatocyte-expressed MHC class I alloantigens is required for tolerance induction. JCI Insight 3: *equally contributed

Raud, B., P.J. McGuire, R.G. Jones, T. Sparwasser, and L. Berod. 2018. Fatty acid metabolism in CD8(+) T cell memory: Challenging current concepts. Immunol Rev 283:213-231.

Raud, B.*, D.G. Roy*, A.S. Divakaruni, T.N. Tarasenko, R. Franke, E.H. Ma, B. Samborska, W.Y. Hsieh, A.H. Wong, P. Stuve, C. Arnold-Schrauf, M. Guderian, M. Lochner, S. Rampertaap, K. Romito, J. Monsale, M. Bronstrup, S.J. Bensinger, A.N. Murphy, P.J. McGuire, R.G. Jones, T. Sparwasser*, and L. Berod*. 2018. Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation. Cell Metab 28:504-515 e507.*equally contributed

Semitekolou, M., I. Morianos, A. Banos, D. Konstantopoulos, M. Adamou-Tzani, T. Sparwasser, and G. Xanthou. 2018. Dendritic cells conditioned by activin A-induced regulatory T cells exhibit enhanced tolerogenic properties and protect against experimental asthma. J Allergy Clin Immunol 141:671-684 e677.

Serradell, M.C., P.R. Gargantini, A. Saura, S.R. Oms, L.L. Rupil, L. Berod, T. Sparwasser, and H.D. Lujan. 2018. Cytokines, Antibodies, and Histopathological Profiles during Giardia Infection and Variant-Specific Surface Protein-Based Vaccination. Infect Immun 86:

Singpiel, A., J. Kramer, R. Maus, J. Stolper, L.F. Bittersohl, J. Gauldie, M. Kolb, T. Welte, T. Sparwasser, and U.A. Maus. 2018. Adenoviral vector-mediated GM-CSF gene transfer improves anti-mycobacterial immunity in mice - role of regulatory T cells. Immunobiology 223:331-341.

Stuve, P.*, L. Minarrieta*, H. Erdmann, C. Arnold-Schrauf, M. Swallow, M. Guderian, F. Krull, A. Holscher, P. Ghorbani, J. Behrends, W.R. Abraham, C. Holscher, T.D. Sparwasser, and L. Berod. 2018. De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages. Front Immunol 9:495. *equally contributed

Velasquez, L.N.*, P. Stuve*, M.V. Gentilini, M. Swallow, J. Bartel, N.Y. Lycke, D. Barkan, M. Martina, H.D. Lujan, H. Kalay, Y. van Kooyk, T.D. Sparwasser, and L. Berod. 2018. Targeting Mycobacterium tuberculosis Antigens to Dendritic Cells via the DC-Specific-ICAM3-Grabbing-Nonintegrin Receptor Induces Strong T-Helper 1 Immune Responses. Front Immunol 9:471. *equally contributed



Alissafi, T., A. Banos, L. Boon, T. Sparwasser, A. Ghigo, K. Wing, D. Vassilopoulos, D. Boumpas, T. Chavakis, K. Cadwell, and P. Verginis. 2017. Tregs restrain dendritic cell autophagy to ameliorate autoimmunity. J Clin Invest 127:2789-2804.

Bieber, K.*, S. Sun*, M. Witte, A. Kasprick, F. Beltsiou, M. Behnen, T. Laskay, F.S. Schulze, E. Pipi, N. Reichhelm, R. Pagel, D. Zillikens, E. Schmidt, T. Sparwasser, K. Kalies, and R.J. Ludwig. 2017. Regulatory T Cells Suppress Inflammation and Blistering in Pemphigoid Diseases. Front Immunol 8:1628. *equally contributed

Friedrich, C.*, P. Mamareli*, S. Thiemann, F. Kruse, Z. Wang, B. Holzmann, T. Strowig, T. Sparwasser*, and M. Lochner*. 2017. MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium. PLoS Pathog 13:e1006357. *equally contributed

Minarrieta, L., P. Ghorbani, T. Sparwasser, and L. Berod. 2017. Metabolites: deciphering the molecular language between DCs and their environment. Semin Immunopathol 39:177-198.

Popovic, B., M. Golemac, J. Podlech, J. Zeleznjak, L. Bilic-Zulle, M.L. Lukic, L. Cicin-Sain, M.J. Reddehase, T. Sparwasser, A. Krmpotic, and S. Jonjic. 2017. IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection. PLoS Pathog 13:e1006345.

van der Vlugt, L.*, K. Obieglo*, A. Ozir-Fazalalikhan, T. Sparwasser, S. Haeberlein, and H.H. Smits. 2017. Schistosome-induced pulmonary B cells inhibit allergic airway inflammation and display a reduced Th2-driving function. Int J Parasitol 47:545-554. *equally contributed

Zischke, J., P. Mamareli, C. Pokoyski, I. Gabaev, S. Buyny, R. Jacobs, C.S. Falk, M. Lochner, T. Sparwasser, T.F. Schulz, and P.C. Kay-Fedorov. 2017. The human cytomegalovirus glycoprotein pUL11 acts via CD45 to induce T cell IL-10 secretion. PLoS Pathog 13:e1006454.



Almeida, L.*, M. Lochner*, L. Berod*, and T. Sparwasser. 2016. Metabolic pathways in T cell activation and lineage differentiation. Semin Immunol 28:514-524. *equally contributed

Dudek, M., F. Puttur, C. Arnold-Schrauf, A.A. Kuhl, B. Holzmann, B. Henriques-Normark, L. Berod*, and T. Sparwasser*. 2016. Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection. Mucosal Immunol 9:1288-1302. *equally contributed

Freitag, J., L. Berod, T. Kamradt, and T. Sparwasser. 2016. Immunometabolism and autoimmunity. Immunol Cell Biol 94:925-934.

Knuschke, T., O. Rotan, W. Bayer, V. Sokolova, W. Hansen, T. Sparwasser, U. Dittmer, M. Epple, J. Buer, and A.M. Westendorf. 2016. Combination of nanoparticle-based therapeutic vaccination and transient ablation of regulatory T cells enhances anti-viral immunity during chronic retroviral infection. Retrovirology 13:24.

Mykicki, N., A.M. Herrmann, N. Schwab, R. Deenen, T. Sparwasser, A. Limmer, L. Wachsmuth, L. Klotz, K. Kohrer, C. Faber, H. Wiendl, T.A. Luger, S.G. Meuth*, and K. Loser*. 2016. Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease. Sci Transl Med 8:362ra146. *equally contributed

Navarro, S., D.A. Pickering, I.B. Ferreira, L. Jones, S. Ryan, S. Troy, A. Leech, P.J. Hotez, B. Zhan, T. Laha, R. Prentice, T. Sparwasser, J. Croese, C.R. Engwerda, J.W. Upham, V. Julia, P.R. Giacomin, and A. Loukas. 2016. Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma. Sci Transl Med 8:362ra143.

Perdicchio, M., J.M. Ilarregui, M.I. Verstege, L.A. Cornelissen, S.T. Schetters, S. Engels, M. Ambrosini, H. Kalay, H. Veninga, J.M. den Haan, L.A. van Berkel, J.N. Samsom, P.R. Crocker, T. Sparwasser, L. Berod, J.J. Garcia-Vallejo, Y. van Kooyk*, and W.W. Unger*. 2016. Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells. Proc Natl Acad Sci U S A 113:3329-3334. *equally contributed

Puttur, F.*, M. Francozo*, G. Solmaz, C. Bueno, M. Lindenberg, M. Gohmert, M. Swallow, D. Tufa, R. Jacobs, S. Lienenklaus, A.A. Kuhl, L. Borkner, L. Cicin-Sain, B. Holzmann, H. Wagner, L. Berod, and T. Sparwasser. 2016. Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via TLR9 and MyD88 Signaling. Cell Rep 17:1113-1127. *equally contributed

Raha, S.*, B. Raud*, L. Oberdorfer, C.N. Castro, A. Schreder, J. Freitag, T. Longerich, M. Lochner, T. Sparwasser, L. Berod, C. Koenecke, and I. Prinz. 2016. Disruption of de novo fatty acid synthesis via acetyl-CoA carboxylase 1 inhibition prevents acute graft-versus-host disease. Eur J Immunol 46:2233-2238. *equally contributed

Smith, K.A., K.J. Filbey, L.A. Reynolds, J.P. Hewitson, Y. Harcus, L. Boon, T. Sparwasser, G. Hammerling, and R.M. Maizels. 2016. Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths. Mucosal Immunol 9:428-443.

Win, S.J., A.A. Kuhl, T. Sparwasser, T. Hunig, and T. Kamradt. 2016. In vivo activation of Treg cells with a CD28 superagonist prevents and ameliorates chronic destructive arthritis in mice. Eur J Immunol 46:1193-1202.

Yang, B.H.*, S. Hagemann*, P. Mamareli, U. Lauer, U. Hoffmann, M. Beckstette, L. Fohse, I. Prinz, J. Pezoldt, S. Suerbaum, T. Sparwasser, A. Hamann, S. Floess*, J. Huehn*, and M. Lochner*. 2016. Foxp3(+) T cells expressing RORgammat represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation. Mucosal Immunol 9:444-457. *equally contributed



Akeus, P., V. Langenes, J. Kristensen, A. von Mentzer, T. Sparwasser, S. Raghavan, and M. Quiding-Jarbrink. 2015. Treg-cell depletion promotes chemokine production and accumulation of CXCR3(+) conventional T cells in intestinal tumors. Eur J Immunol 45:1654-1666.

Alissafi, T., A. Hatzioannou, M. Ioannou, T. Sparwasser, J.R. Grun, A. Grutzkau, and P. Verginis. 2015. De novo-induced self-antigen-specific Foxp3+ regulatory T cells impair the accumulation of inflammatory dendritic cells in draining lymph nodes. J Immunol 194:5812-5824.

Arnold-Schrauf, C., L. Berod, and T. Sparwasser. 2015. Dendritic cell specific targeting of MyD88 signalling pathways in vivo. Eur J Immunol 45:32-39.

Bolton, H.A., E. Zhu, A.M. Terry, T.V. Guy, W.P. Koh, S.Y. Tan, C.A. Power, P. Bertolino, K. Lahl, T. Sparwasser, E. Shklovskaya, and B. Fazekas de St Groth. 2015. Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease. J Clin Invest 125:3627-3641.

Bothur, E.*, H. Raifer*, C. Haftmann, A.B. Stittrich, A. Brustle, D. Brenner, N. Bollig, M. Bieringer, C.H. Kang, K. Reinhard, B. Camara, M. Huber, A. Visekruna, U. Steinhoff, A. Repenning, U.M. Bauer, V. Sexl, A. Radbruch, T. Sparwasser, M.F. Mashreghi, T. Wah Mak, and M. Lohoff. 2015. Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1. Nat Commun 6:8576. *equally contributed

Castro, C.N.*, J. Freitag*, L. Berod, M. Lochner, and T. Sparwasser. 2015. Microbe-associated immunomodulatory metabolites: Influence on T cell fate and function. Mol Immunol 68:575-584. *equally contributed

Dhainaut, M.*, C. Coquerelle*, S. Uzureau, J. Denoeud, V. Acolty, G. Oldenhove, A. Galuppo, T. Sparwasser, K. Thielemans, E. Pays, H. Yagita, J. Borst, and M. Moser. 2015. Thymus-derived regulatory T cells restrain pro-inflammatory Th1 responses by downregulating CD70 on dendritic cells. EMBO J 34:1336-1348. *equally contributed

Khan, A.R., S. Amu, S.P. Saunders, E. Hams, G. Blackshields, M.O. Leonard, C.T. Weaver, T. Sparwasser, O. Sheils, and P.G. Fallon. 2015. Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells. Eur J Immunol 45:1842-1854.

Khan, A.R., E. Hams, A. Floudas, T. Sparwasser, C.T. Weaver, and P.G. Fallon. 2015. PD-L1hi B cells are critical regulators of humoral immunity. Nat Commun 6:5997.

Legoux, F.P., J.B. Lim, A.W. Cauley, S. Dikiy, J. Ertelt, T.J. Mariani, T. Sparwasser, S.S. Way, and J.J. Moon. 2015. CD4+ T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion. Immunity 43:896-908.

Lochner, M.*, L. Berod*, and T. Sparwasser. 2015. Fatty acid metabolism in the regulation of T cell function. Trends Immunol 36:81-91. *equally contributed

Lochner, M., Z. Wang, and T. Sparwasser. 2015. The Special Relationship in the Development and Function of T Helper 17 and Regulatory T Cells. Prog Mol Biol Transl Sci 136:99-129.

Mahapatra, S.*, M. Albrecht*, A.M. Baru, T. Sparwasser, C. Herrick, and A.M. Dittrich. 2015. Superior Suppressive Capacity of Skin Tregs Compared with Lung Tregs in a Model of Epicutaneous Priming. J Invest Dermatol 135:2418-2426. *equally contributed

Molina, M.A., A.M. Diaz, C. Hesse, W. Ginter, M.V. Gentilini, G.G. Nunez, A.M. Canellada, T. Sparwasser, L. Berod, M.S. Castro, and M.A. Manghi. 2015. Immunostimulatory Effects Triggered by Enterococcus faecalis CECT7121 Probiotic Strain Involve Activation of Dendritic Cells and Interferon-Gamma Production. PLoS One 10:e0127262.

Niedzielska, M., F.A. Raffi*, J. Tel*, S. Muench, K. Jozefowski, N. Alati, K. Lahl, J. Mages, U. Billmeier, M. Schiemann, U.K. Appelt, S. Wirtz, T. Sparwasser, H. Hochrein, C.G. Figdor, S.M. Keyse, and R. Lang. 2015. Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-beta Production. J Immunol 195:1753-1762. *equally contributed

Schuhmann, M.K.*, P. Kraft*, G. Stoll, K. Lorenz, S.G. Meuth, H. Wiendl, B. Nieswandt, T. Sparwasser, N. Beyersdorf, T. Kerkau, and C. Kleinschnitz. 2015. CD28 superagonist-mediated boost of regulatory T cells increases thrombo-inflammation and ischemic neurodegeneration during the acute phase of experimental stroke. J Cereb Blood Flow Metab 35:6-10. *equally contributed

Tebartz, C.*, S.A. Horst*, T. Sparwasser, J. Huehn, A. Beineke, G. Peters, and E. Medina. 2015. A major role for myeloid-derived suppressor cells and a minor role for regulatory T cells in immunosuppression during Staphylococcus aureus infection. J Immunol 194:1100-1111. *equally contributed

Torow, N., K. Yu, K. Hassani, J. Freitag, O. Schulz, M. Basic, A. Brennecke, T. Sparwasser, N. Wagner, A. Bleich, M. Lochner, S. Weiss, R. Forster, O. Pabst, and M.W. Hornef. 2015. Active suppression of intestinal CD4(+)TCRalphabeta(+) T-lymphocyte maturation during the postnatal period. Nat Commun 6:7725.

Unger, W.W.*, C.T. Mayer*, S. Engels, C. Hesse, M. Perdicchio, F. Puttur, I. Streng-Ouwehand, M. Litjens, H. Kalay, L. Berod, T. Sparwasser, and Y. van Kooyk. 2015. Antigen targeting to dendritic cells combined with transient regulatory T cell inhibition results in long-term tumor regression. Oncoimmunology 4:e970462. *equally contributed

Yang, B.H.*, S. Floess*, S. Hagemann, I.V. Deyneko, L. Groebe, J. Pezoldt, T. Sparwasser, M. Lochner, and J. Huehn. 2015. Development of a unique epigenetic signature during in vivo Th17 differentiation. Nucleic Acids Res 43:1537-1548. *equally contributed

Yodoi, K., T. Yamashita*, N. Sasaki*, K. Kasahara, T. Emoto, T. Matsumoto, T. Kita, Y. Sasaki, T. Mizoguchi, T. Sparwasser, and K. Hirata. 2015. Foxp3+ regulatory T cells play a protective role in angiotensin II-induced aortic aneurysm formation in mice. Hypertension 65:889-895. *equally contributed



Arnold-Schrauf, C., M. Dudek, A. Dielmann, L. Pace, M. Swallow, F. Kruse, A.A. Kuhl, B. Holzmann, L. Berod*, and T. Sparwasser*. 2014. Dendritic cells coordinate innate immunity via MyD88 signaling to control Listeria monocytogenes infection. Cell Rep 6:698-708. *equally contributed

Berod, L.*, C. Friedrich*, A. Nandan*, J. Freitag, S. Hagemann, K. Harmrolfs, A. Sandouk, C. Hesse, C.N. Castro, H. Bahre, S.K. Tschirner, N. Gorinski, M. Gohmert, C.T. Mayer, J. Huehn, E. Ponimaskin, W.R. Abraham, R. Muller, M. Lochner*, and T. Sparwasser*. 2014. De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat Med 20:1327-1333. *equally contributed

Berod, L.*, P. Stuve*, M. Swallow, C. Arnold-Schrauf, F. Kruse, M.V. Gentilini, J. Freitag, B. Holzmann, and T. Sparwasser. 2014. MyD88 signalling in myeloid cells is sufficient to prevent chronic mycobacterial infection. Eur J Immunol 44:1399-1409. *equally contributed

Berod, L., P. Stuve, F. Varela, J. Behrends, M. Swallow, F. Kruse, F. Krull, P. Ghorbani, C.T. Mayer, C. Holscher, and T. Sparwasser. 2014. Rapid rebound of the Treg compartment in DEREG mice limits the impact of Treg depletion on mycobacterial burden, but prevents autoimmunity. PLoS One 9:e102804.

Blankenhaus, B.*, M. Reitz*, Y. Brenz, M.L. Eschbach, W. Hartmann, I. Haben, T. Sparwasser, J. Huehn, A. Kuhl, T.B. Feyerabend, H.R. Rodewald, and M. Breloer. 2014. Foxp3(+) regulatory T cells delay expulsion of intestinal nematodes by suppression of IL-9-driven mast cell activation in BALB/c but not in C57BL/6 mice. PLoS Pathog 10:e1003913. *equally contributed

Chrobak, P., S. Afkhami, E. Priceputu, J. Poudrier, C. Meunier, Z. Hanna, T. Sparwasser, and P. Jolicoeur. 2014. HIV Nef expression favors the relative preservation of CD4+ T regulatory cells that retain some important suppressive functions. J Immunol 192:1681-1692.

Ehrlich, A., T.M. Castilho, K. Goldsmith-Pestana, W.J. Chae, A.L. Bothwell, T. Sparwasser, and D. McMahon-Pratt. 2014. The immunotherapeutic role of regulatory T cells in Leishmania (Viannia) panamensis infection. J Immunol 193:2961-2970.

Espinoza Mora, M.R., C. Steeg, S. Tartz, V. Heussler, T. Sparwasser, A. Link, B. Fleischer, and T. Jacobs. 2014. Depletion of regulatory T cells augments a vaccine-induced T effector cell response against the liver-stage of malaria but fails to increase memory. PLoS One 9:e104627.

Ganesh, V.*, A.M. Baru*, C. Hesse, C. Friedrich, S. Glage, M. Gohmert, C. Janke, and T. Sparwasser. 2014. Salmonella enterica serovar Typhimurium infection-induced CD11b+ Gr1+ cells ameliorate allergic airway inflammation. Infect Immun 82:1052-1063. *equally contributed

Jost, N.H., S. Abel, M. Hutzler, T. Sparwasser, A. Zimmermann, A. Roers, W. Muller, R. Klopfleisch, H. Hengel, A.M. Westendorf, J. Buer, and W. Hansen. 2014. Regulatory T cells and T-cell-derived IL-10 interfere with effective anti-cytomegalovirus immune response. Immunol Cell Biol 92:860-871.

Lindenberg, M., G. Solmaz, F. Puttur, and T. Sparwasser. 2014. Mouse cytomegalovirus infection overrules T regulatory cell suppression on natural killer cells. Virol J 11:145.

Mayer, C.T.*, P. Ghorbani*, A.A. Kuhl, P. Stuve, M. Hegemann, L. Berod, M.E. Gershwin, and T. Sparwasser. 2014. Few Foxp3(+) regulatory T cells are sufficient to protect adult mice from lethal autoimmunity. Eur J Immunol 44:2990-3002. *equally contributed

Mayer, C.T.*, P. Ghorbani*, A. Nandan, M. Dudek, C. Arnold-Schrauf, C. Hesse, L. Berod, P. Stuve, F. Puttur, M. Merad, and T. Sparwasser. 2014. Selective and efficient generation of functional Batf3-dependent CD103+ dendritic cells from mouse bone marrow. Blood 124:3081-3091. *equally contributed

Mayer, C.T., K. Lahl, P. Milanez-Almeida, D. Watts, U. Dittmer, N. Fyhrquist, J. Huehn, M. Kopf, K. Kretschmer, B. Rouse, and T. Sparwasser. 2014. Advantages of Foxp3(+) regulatory T cell depletion using DEREG mice. Immun Inflamm Dis 2:162-165.

Mayer, C.T., and T. Sparwasser. 2014. Assessing the suppressive activity of Foxp3(+) regulatory T cells. Methods Mol Biol 1193:85-96.

Mayer, C.T., L. Tian, C. Hesse, A.A. Kuhl, M. Swallow, F. Kruse, M. Thiele, M.E. Gershwin, A. Liston, and T. Sparwasser. 2014. Anti-CD4 treatment inhibits autoimmunity in scurfy mice through the attenuation of co-stimulatory signals. J Autoimmun 50:23-32.

Meyer zu Horste, G., S. Cordes, A.K. Mausberg, A.L. Zozulya, C. Wessig, T. Sparwasser, C. Mathys, H. Wiendl, H.P. Hartung, and B.C. Kieseier. 2014. FoxP3+ regulatory T cells determine disease severity in rodent models of inflammatory neuropathies. PLoS One 9:e108756.

Niedzielska, M., B. Bodendorfer, S. Munch, A. Eichner, M. Derigs, O. da Costa, A. Schweizer, F. Neff, L. Nitschke, T. Sparwasser, S.M. Keyse, and R. Lang. 2014. Gene trap mice reveal an essential function of dual specificity phosphatase Dusp16/MKP-7 in perinatal survival and regulation of Toll-like receptor (TLR)-induced cytokine production. J Biol Chem 289:2112-2126.

Pastille, E., K. Bardini, D. Fleissner, A. Adamczyk, A. Frede, M. Wadwa, D. von Smolinski, S. Kasper, T. Sparwasser, A.D. Gruber, M. Schuler, S. Sakaguchi, A. Roers, W. Muller, W. Hansen, J. Buer, and A.M. Westendorf. 2014. Transient ablation of regulatory T cells improves antitumor immunity in colitis-associated colon cancer. Cancer Res 74:4258-4269.

Petzold, C., N. Steinbronn, M. Gereke, R.H. Strasser, T. Sparwasser, D. Bruder, R. Geffers, S. Schallenberg*, and K. Kretschmer*. 2014. Fluorochrome-based definition of naturally occurring Foxp3(+) regulatory T cells of intra- and extrathymic origin. Eur J Immunol 44:3632-3645. *equally contributed

Schulze, B., D. Piehler, M. Eschke, H. von Buttlar, G. Kohler, T. Sparwasser, and G. Alber. 2014. CD4(+) FoxP3(+) regulatory T cells suppress fatal T helper 2 cell immunity during pulmonary fungal infection. Eur J Immunol 44:3596-3604.

Villalta, S.A., W. Rosenthal, L. Martinez, A. Kaur, T. Sparwasser, J.G. Tidball, M. Margeta, M.J. Spencer, and J.A. Bluestone. 2014. Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy. Sci Transl Med 6:258ra142.

Wang, Y., T. Sparwasser, R. Figlin, and H.L. Kim. 2014. Foxp3+ T cells inhibit antitumor immune memory modulated by mTOR inhibition. Cancer Res 74:2217-2228.

Wang, Z., C. Friedrich, S.C. Hagemann, W.H. Korte, N. Goharani, S. Cording, G. Eberl, T. Sparwasser*, and M. Lochner*. 2014. Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium. Mucosal Immunol 7:1290-1301.
*equally contributed



Akhmetzyanova, I., G. Zelinskyy, S. Schimmer, S. Brandau, P. Altenhoff, T. Sparwasser, and U. Dittmer. 2013. Tumor-specific CD4+ T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells. Cancer Immunol Immunother 62:257-271.

Chai, Q.*, L. Onder*, E. Scandella, C. Gil-Cruz, C. Perez-Shibayama, J. Cupovic, R. Danuser, T. Sparwasser, S.A. Luther, V. Thiel, T. Rulicke, J.V. Stein, T. Hehlgans, and B. Ludewig. 2013. Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity. Immunity 38:1013-1024. *equally contributed

Fernandez, M.A., U. Yu, G. Zhang, R. White, T. Sparwasser, S.I. Alexander, and C.A. Jones. 2013. Treg depletion attenuates the severity of skin disease from ganglionic spread after HSV-2 flank infection. Virology 447:9-20.

Hesse, C.*, W. Ginter*, T. Forg, C.T. Mayer, A.M. Baru, C. Arnold-Schrauf, W.W. Unger, H. Kalay, Y. van Kooyk, L. Berod*, and T. Sparwasser*. 2013. In vivo targeting of human DC-SIGN drastically enhances CD8(+) T-cell-mediated protective immunity. Eur J Immunol 43:2543-2553. *equally contributed

Hu, M., C. Wang, G.Y. Zhang, M. Saito, Y.M. Wang, M.A. Fernandez, Y. Wang, H. Wu, W.J. Hawthorne, C. Jones, P.J. O'Connell, T. Sparwasser, G.A. Bishop, A.F. Sharland, and S.I. Alexander. 2013. Infiltrating Foxp3(+) regulatory T cells from spontaneously tolerant kidney allografts demonstrate donor-specific tolerance. Am J Transplant 13:2819-2830.

Kanjarawi, R., M. Dy, E. Bardel, T. Sparwasser, B. Dubois, S. Mecheri, and D. Kaiserlian. 2013. Regulatory CD4+Foxp3+ T cells control the severity of anaphylaxis. PLoS One 8:e69183.

Kleinschnitz, C.*, P. Kraft*, A. Dreykluft, I. Hagedorn, K. Gobel, M.K. Schuhmann, F. Langhauser, X. Helluy, T. Schwarz, S. Bittner, C.T. Mayer, M. Brede, C. Varallyay, M. Pham, M. Bendszus, P. Jakob, T. Magnus, S.G. Meuth, Y. Iwakura, A. Zernecke, T. Sparwasser, B. Nieswandt, G. Stoll, and H. Wiendl. 2013. Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. Blood 121:679-691. *equally contributed

Klingenberg, R.*, N. Gerdes*, R.M. Badeau, A. Gistera, D. Strodthoff, D.F. Ketelhuth, A.M. Lundberg, M. Rudling, S.K. Nilsson, G. Olivecrona, S. Zoller, C. Lohmann, T.F. Luscher, M. Jauhiainen, T. Sparwasser, and G.K. Hansson. 2013. Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis. J Clin Invest 123:1323-1334. *equally contributed

Kuhlhorn, F.*, M. Rath*, K. Schmoeckel, K. Cziupka, H.H. Nguyen, P. Hildebrandt, T. Hunig, T. Sparwasser, J. Huehn, C. Potschke*, and B.M. Broker*. 2013. Foxp3+ regulatory T cells are required for recovery from severe sepsis. PLoS One 8:e65109. *equally contributed

Layland, L.E.*, K. Straubinger*, M. Ritter, E. Loffredo-Verde, H. Garn, T. Sparwasser, and C. Prazeres da Costa. 2013. Schistosoma mansoni-mediated suppression of allergic airway inflammation requires patency and Foxp3+ Treg cells. PLoS Negl Trop Dis 7:e2379. *equally contributed

Martin, B.*, C. Auffray*, A. Delpoux, A. Pommier, A. Durand, C. Charvet, P. Yakonowsky, H. de Boysson, N. Bonilla, A. Audemard, T. Sparwasser, B.L. Salomon, B. Malissen, and B. Lucas. 2013. Highly self-reactive naive CD4 T cells are prone to differentiate into regulatory T cells. Nat Commun 4:2209. *equally contributed

Mayer, C.T., J. Huntenburg, A. Nandan, E. Schmitt, N. Czeloth, and T. Sparwasser. 2013. CD4 blockade directly inhibits mouse and human CD4(+) T cell functions independent of Foxp3(+) Tregs. J Autoimmun 47:73-82.

Pasquet, L., J.Y. Douet, T. Sparwasser, P. Romagnoli, and J.P. van Meerwijk. 2013. Long-term prevention of chronic allograft rejection by regulatory T-cell immunotherapy involves host Foxp3-expressing T cells. Blood 121:4303-4310.

Petzold, C., J. Riewaldt, D. Watts, T. Sparwasser, S. Schallenberg, and K. Kretschmer. 2013. Foxp3(+) regulatory T cells in mouse models of type 1 diabetes. J Diabetes Res 2013:940710.

Puttur, F.*, C. Arnold-Schrauf*, K. Lahl, G. Solmaz, M. Lindenberg, C.T. Mayer, M. Gohmert, M. Swallow, C. van Helt, H. Schmitt, L. Nitschke, B.N. Lambrecht, R. Lang, M. Messerle, and T. Sparwasser. 2013. Absence of Siglec-H in MCMV infection elevates interferon alpha production but does not enhance viral clearance. PLoS Pathog 9:e1003648. *equally contributed

Rosalia, R.A.*, I. Stepanek*, V. Pollakova, J. Simova, J. Bieblova, M. Indrova, S. Moravcova, H. Pribylova, H.J. Bontkes, J. Bubenik, T. Sparwasser, and M. Reinis. 2013. Administration of anti-CD25 mAb leads to impaired alpha-galactosylceramide-mediated induction of IFN-gamma production in a murine model. Immunobiology 218:851-859. *equally contributed

Schmitz, I., C. Schneider, A. Frohlich, H. Frebel, D. Christ, W.J. Leonard, T. Sparwasser, A. Oxenius, S. Freigang*, and M. Kopf*. 2013. IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection. PLoS Pathog 9:e1003362. *equally contributed

Worthington, J.J.*, J.E. Klementowicz*, S. Rahman, B.I. Czajkowska, C. Smedley, H. Waldmann, T. Sparwasser, R.K. Grencis, and M.A. Travis. 2013. Loss of the TGFbeta-activating integrin alphavbeta8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunity. PLoS Pathog 9:e1003675. *equally contributed



Abel, S., N. Luckheide, A.M. Westendorf, R. Geffers, A. Roers, W. Muller, T. Sparwasser, K. Matuschewski, J. Buer, and W. Hansen. 2012. Strong impact of CD4+ Foxp3+ regulatory T cells and limited effect of T cell-derived IL-10 on pathogen clearance during Plasmodium yoelii infection. J Immunol 188:5467-5477.

Auriemma, M.*, T. Brzoska*, L. Klenner, V. Kupas, T. Goerge, M. Voskort, Z. Zhao, T. Sparwasser, T.A. Luger*, and K. Loser*. 2012. alpha-MSH-stimulated tolerogenic dendritic cells induce functional regulatory T cells and ameliorate ongoing skin inflammation. J Invest Dermatol 132:1814-1824. *equally contributed

Baru, A.M., V. Ganesh, J.K. Krishnaswamy, C. Hesse, C. Untucht, S. Glage, G. Behrens, C.T. Mayer, F. Puttur, and T. Sparwasser. 2012. Absence of Foxp3+ regulatory T cells during allergen provocation does not exacerbate murine allergic airway inflammation. PLoS One 7:e47102.

Baru, A.M., C. Untucht*, V. Ganesh*, C. Hesse, C.T. Mayer, and T. Sparwasser. 2012. Optimal isolation of functional Foxp3+ induced regulatory T cells using DEREG mice. PLoS One 7:e44760. *equally contributed

Berod, L.*, F. Puttur*, J. Huehn, and T. Sparwasser. 2012. Tregs in infection and vaccinology: heroes or traitors? Microb Biotechnol 5:260-269. *equally contributed

Cervantes-Barragan, L.*, S. Firner*, I. Bechmann, A. Waisman, K. Lahl, T. Sparwasser, V. Thiel, and B. Ludewig. 2012. Regulatory T cells selectively preserve immune privilege of self-antigens during viral central nervous system infection. J Immunol 188:3678-3685. *equally contributed

Eberlein, J., B. Davenport, T.T. Nguyen, F. Victorino, T. Sparwasser, and D. Homann. 2012. Multiple layers of CD80/86-dependent costimulatory activity regulate primary, memory, and secondary lymphocytic choriomeningitis virus-specific T cell immunity. J Virol 86:1955-1970.

Fyhrquist, N., S. Lehtimaki, K. Lahl, T. Savinko, A.M. Lappetelainen, T. Sparwasser, H. Wolff, A. Lauerma, and H. Alenius. 2012. Foxp3+ cells control Th2 responses in a murine model of atopic dermatitis. J Invest Dermatol 132:1672-1680.

Gomez de Aguero, M., M. Vocanson, F. Hacini-Rachinel, M. Taillardet, T. Sparwasser, A. Kissenpfennig, B. Malissen, D. Kaiserlian, and B. Dubois. 2012. Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8(+) T cells and activating Foxp3(+) regulatory T cells. J Clin Invest 122:1700-1711.

Hansen, W., M. Hutzler, S. Abel, C. Alter, C. Stockmann, S. Kliche, J. Albert, T. Sparwasser, S. Sakaguchi, A.M. Westendorf, D. Schadendorf, J. Buer*, and I. Helfrich*. 2012. Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth. J Exp Med 209:2001-2016. *equally contributed

Hellingman, A.A., L.E. van der Vlugt, M.A. Lijkwan, A.J. Bastiaansen, T. Sparwasser, H.H. Smits, J.F. Hamming, and P.H. Quax. 2012. A limited role for regulatory T cells in post-ischemic neovascularization. J Cell Mol Med 16:328-336.

Krishnaswamy, J.K., A.C. Jirmo, A.M. Baru, T. Ebensen, C.A. Guzman, T. Sparwasser, and G.M. Behrens. 2012. Toll-like receptor-2 agonist-allergen coupling efficiently redirects Th2 cell responses and inhibits allergic airway eosinophilia. Am J Respir Cell Mol Biol 47:852-863.

Lehtimaki, S., T. Savinko, K. Lahl, T. Sparwasser, H. Wolff, A. Lauerma, H. Alenius, and N. Fyhrquist. 2012. The temporal and spatial dynamics of Foxp3+ Treg cell-mediated suppression during contact hypersensitivity responses in a murine model. J Invest Dermatol 132:2744-2751.

Loebbermann, J., H. Thornton, L. Durant, T. Sparwasser, K.E. Webster, J. Sprent, F.J. Culley, C. Johansson*, and P.J. Openshaw*. 2012. Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection. Mucosal Immunol 5:161-172. *equally contributed

Maazi, H., S. Shirinbak, M. Willart, H.M. Hammad, M. Cabanski, L. Boon, V. Ganesh, A.M. Baru, G. Hansen, B.N. Lambrecht, T. Sparwasser, M.C. Nawijn, and A.J. van Oosterhout. 2012. Contribution of regulatory T cells to alleviation of experimental allergic asthma after specific immunotherapy. Clin Exp Allergy 42:1519-1528.

Mayer, C.T., L. Berod, and T. Sparwasser. 2012. Layers of dendritic cell-mediated T cell tolerance, their regulation and the prevention of autoimmunity. Front Immunol 3:183.

Mayer, C.T., A.A. Kuhl, C. Loddenkemper, and T. Sparwasser. 2012. Lack of Foxp3+ macrophages in both untreated and B16 melanoma-bearing mice. Blood 119:1314-1315.

Navid, F., M. Boniotto, C. Walker, K. Ahrens, E. Proksch, T. Sparwasser, W. Muller, T. Schwarz, and A. Schwarz. 2012. Induction of regulatory T cells by a murine beta-defensin. J Immunol 188:735-743.

Ohkura, N.*, M. Hamaguchi*, H. Morikawa, K. Sugimura, A. Tanaka, Y. Ito, M. Osaki, Y. Tanaka, R. Yamashita, N. Nakano, J. Huehn, H.J. Fehling, T. Sparwasser, K. Nakai, and S. Sakaguchi. 2012. T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. Immunity 37:785-799. *equally contributed

Pace, L., A. Tempez, C. Arnold-Schrauf, F. Lemaitre, P. Bousso, L. Fetler*, T. Sparwasser*, and S. Amigorena. 2012. Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory. Science 338:532-536. *equally contributed

Panzer, M., S. Sitte, S. Wirth, I. Drexler, T. Sparwasser, and D. Voehringer. 2012. Rapid in vivo conversion of effector T cells into Th2 cells during helminth infection. J Immunol 188:615-623.

Reuter, D., T. Sparwasser, T. Hunig, and J. Schneider-Schaulies. 2012. Foxp3+ regulatory T cells control persistence of viral CNS infection. PLoS One 7:e33989.

Robb, R.J., K.E. Lineburg, R.D. Kuns, Y.A. Wilson, N.C. Raffelt, S.D. Olver, A. Varelias, K.A. Alexander, B.E. Teal, T. Sparwasser, G.J. Hammerling, K.A. Markey, M. Koyama, A.D. Clouston, C.R. Engwerda, G.R. Hill*, and K.P. MacDonald*. 2012. Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation. Blood 119:5898-5908. *equally contributed

Schallenberg, S.*, C. Petzold*, P.Y. Tsai, T. Sparwasser, and K. Kretschmer. 2012. Vagaries of fluorochrome reporter gene expression in Foxp3+ regulatory T cells. PLoS One 7:e41971. *equally contributed

Schuster, M., R. Glauben, C. Plaza-Sirvent, L. Schreiber, M. Annemann, S. Floess, A.A. Kuhl, L.K. Clayton, T. Sparwasser, K. Schulze-Osthoff, K. Pfeffer, J. Huehn, B. Siegmund, and I. Schmitz. 2012. IkappaB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor. Immunity 37:998-1008.

Schwarz, A., F. Navid, T. Sparwasser, B.E. Clausen, and T. Schwarz. 2012. 1,25-dihydroxyvitamin D exerts similar immunosuppressive effects as UVR but is dispensable for local UVR-induced immunosuppression. J Invest Dermatol 132:2762-2769.

Stross, L., J. Gunther, G. Gasteiger, T. Asen, S. Graf, M. Aichler, I. Esposito, D.H. Busch, P. Knolle, T. Sparwasser, and U. Protzer. 2012. Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute experimental hepatitis B virus infection in mice. Hepatology 56:873-883.

van der Vlugt, L.E., L.A. Labuda, A. Ozir-Fazalalikhan, E. Lievers, A.K. Gloudemans, K.Y. Liu, T.A. Barr, T. Sparwasser, L. Boon, U.A. Ngoa, E.N. Feugap, A.A. Adegnika, P.G. Kremsner, D. Gray, M. Yazdanbakhsh, and H.H. Smits. 2012. Schistosomes induce regulatory features in human and mouse CD1d(hi) B cells: inhibition of allergic inflammation by IL-10 and regulatory T cells. PLoS One 7:e30883.

Veiga-Parga, T., A. Suryawanshi, S. Mulik, F. Gimenez, S. Sharma, T. Sparwasser, and B.T. Rouse. 2012. On the role of regulatory T cells during viral-induced inflammatory lesions. J Immunol 189:5924-5933.

Zhao, E.*, L. Wang*, J. Dai, I. Kryczek, S. Wei, L. Vatan, S. Altuwaijri, T. Sparwasser, G. Wang, E.T. Keller, and W. Zou. 2012. Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer. Oncoimmunology 1:152-161. *equally contributed



Arnold, I.C., J.Y. Lee, M.R. Amieva, A. Roers, R.A. Flavell, T. Sparwasser, and A. Muller. 2011. Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia. Gastroenterology 140:199-209.

Beyer, M., Y. Thabet, R.U. Muller, T. Sadlon, S. Classen, K. Lahl, S. Basu, X. Zhou, S.L. Bailey-Bucktrout, W. Krebs, E.A. Schonfeld, J. Bottcher, T. Golovina, C.T. Mayer, A. Hofmann, D. Sommer, S. Debey-Pascher, E. Endl, A. Limmer, K.L. Hippen, B.R. Blazar, R. Balderas, T. Quast, A. Waha, G. Mayer, M. Famulok, P.A. Knolle, C. Wickenhauser, W. Kolanus, B. Schermer, J.A. Bluestone, S.C. Barry, T. Sparwasser, J.L. Riley, and J.L. Schultze. 2011. Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nat Immunol 12:898-907.

Blankenhaus, B.*, U. Klemm*, M.L. Eschbach, T. Sparwasser, J. Huehn, A.A. Kuhl, C. Loddenkemper, T. Jacobs, and M. Breloer. 2011. Strongyloides ratti infection induces expansion of Foxp3+ regulatory T cells that interfere with immune response and parasite clearance in BALB/c mice. J Immunol 186:4295-4305. *equally contributed

Cassani, B.*, E.J. Villablanca*, F.J. Quintana, P.E. Love, A. Lacy-Hulbert, W.S. Blaner, T. Sparwasser, S.B. Snapper, H.L. Weiner, and J.R. Mora. 2011. Gut-tropic T cells that express integrin alpha4beta7 and CCR9 are required for induction of oral immune tolerance in mice. Gastroenterology 141:2109-2118. *equally contributed

Dietze, K.K., G. Zelinskyy, K. Gibbert, S. Schimmer, S. Francois, L. Myers, T. Sparwasser, K.J. Hasenkrug, and U. Dittmer. 2011. Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8+ T cells and reduces chronic retroviral set points. Proc Natl Acad Sci U S A 108:2420-2425.

Hackl, D., J. Loschko, T. Sparwasser, W. Reindl, and A.B. Krug. 2011. Activation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced Tregs. Eur J Immunol 41:1334-1343.

Hadis, U., B. Wahl, O. Schulz, M. Hardtke-Wolenski, A. Schippers, N. Wagner, W. Muller, T. Sparwasser, R. Forster, and O. Pabst. 2011. Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. Immunity 34:237-246.

Kastenmuller, W.*, G. Gasteiger*, N. Subramanian, T. Sparwasser, D.H. Busch, Y. Belkaid, I. Drexler, and R.N. Germain. 2011. Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction. J Immunol 187:3186-3197. *equally contributed

Lahl, K., and T. Sparwasser. 2011. In vivo depletion of FoxP3+ Tregs using the DEREG mouse model. Methods Mol Biol 707:157-172.

Lo Re, S., M. Lecocq, F. Uwambayinema, Y. Yakoub, M. Delos, J.B. Demoulin, S. Lucas, T. Sparwasser, J.C. Renauld, D. Lison, and F. Huaux. 2011. Platelet-derived growth factor-producing CD4+ Foxp3+ regulatory T lymphocytes promote lung fibrosis. Am J Respir Crit Care Med 184:1270-1281.

Mayer, C.T., S. Floess, A.M. Baru, K. Lahl, J. Huehn, and T. Sparwasser. 2011. CD8+ Foxp3+ T cells share developmental and phenotypic features with classical CD4+ Foxp3+ regulatory T cells but lack potent suppressive activity. Eur J Immunol 41:716-725.

McNally, A., G.R. Hill, T. Sparwasser, R. Thomas, and R.J. Steptoe. 2011. CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis. Proc Natl Acad Sci U S A 108:7529-7534.

Navarro, S., G. Cossalter, C. Chiavaroli, A. Kanda, S. Fleury, A. Lazzari, J. Cazareth, T. Sparwasser, D. Dombrowicz, N. Glaichenhaus, and V. Julia. 2011. The oral administration of bacterial extracts prevents asthma via the recruitment of regulatory T cells to the airways. Mucosal Immunol 4:53-65.

Olivier, A.*, A. Sainz-Perez*, H. Dong, T. Sparwasser, L. Majlessi, and C. Leclerc. 2011. The adjuvant effect of TLR agonists on CD4(+) effector T cells is under the indirect control of regulatory T cells. Eur J Immunol 41:2303-2313. *equally contributed

Onder, L., E. Scandella, Q. Chai, S. Firner, C.T. Mayer, T. Sparwasser, V. Thiel, T. Rulicke, and B. Ludewig. 2011. A novel bacterial artificial chromosome-transgenic podoplanin-cre mouse targets lymphoid organ stromal cells in vivo. Front Immunol 2:50.

Paust, H.J.*, A. Ostmann*, A. Erhardt, J.E. Turner, J. Velden, H.W. Mittrucker, T. Sparwasser, U. Panzer, and G. Tiegs. 2011. Regulatory T cells control the Th1 immune response in murine crescentic glomerulonephritis. Kidney Int 80:154-164. *equally contributed

Pellegrini, M.*, T. Calzascia*, J.G. Toe, S.P. Preston, A.E. Lin, A.R. Elford, A. Shahinian, P.A. Lang, K.S. Lang, M. Morre, B. Assouline, K. Lahl, T. Sparwasser, T.F. Tedder, J.H. Paik, R.A. DePinho, S. Basta, P.S. Ohashi*, and T.W. Mak*. 2011. IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell 144:601-613. *equally contributed

Schwarz, A., F. Navid, T. Sparwasser, B.E. Clausen, and T. Schwarz. 2011. In vivo reprogramming of UV radiation-induced regulatory T-cell migration to inhibit the elicitation of contact hypersensitivity. J Allergy Clin Immunol 128:826-833.

Seung, E., J.L. Cho, T. Sparwasser, B.D. Medoff, and A.D. Luster. 2011. Inhibiting CXCR3-dependent CD8+ T cell trafficking enhances tolerance induction in a mouse model of lung rejection. J Immunol 186:6830-6838.

Stagg, J., U. Divisekera, H. Duret, T. Sparwasser, M.W. Teng, P.K. Darcy, and M.J. Smyth. 2011. CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis. Cancer Res 71:2892-2900.

Tacken, P.J., W. Ginter, L. Berod, L.J. Cruz, B. Joosten, T. Sparwasser, C.G. Figdor, and A. Cambi. 2011. Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation. Blood 118:4111-4119.

Vaeth, M.*, T. Gogishvili*, T. Bopp*, M. Klein, F. Berberich-Siebelt, S. Gattenloehner, A. Avots, T. Sparwasser, N. Grebe, E. Schmitt, T. Hunig, E. Serfling*, and J. Bodor*. 2011. Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1). Proc Natl Acad Sci U S A 108:2480-2485. *equally contributed

Weiss, E.M., A. Schmidt, D. Vobis, N. Garbi, K. Lahl, C.T. Mayer, T. Sparwasser, A. Ludwig, E. Suri-Payer, N. Oberle*, and P.H. Krammer*. 2011. Foxp3-mediated suppression of CD95L expression confers resistance to activation-induced cell death in regulatory T cells. J Immunol 187:1684-1691. *equally contributed

Wheeler, K., S. Tardif, C. Rival, B. Luu, E. Bui, R. Del Rio, C. Teuscher, T. Sparwasser, D. Hardy, and K.S. Tung. 2011. Regulatory T cells control tolerogenic versus autoimmune response to sperm in vasectomy. Proc Natl Acad Sci U S A 108:7511-7516.

Wilhelm, C., K. Hirota, B. Stieglitz, J. Van Snick, M. Tolaini, K. Lahl, T. Sparwasser, H. Helmby, and B. Stockinger. 2011. An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nat Immunol 12:1071-1077.

Woller, N., S. Knocke, B. Mundt, E. Gurlevik, N. Struver, A. Kloos, B. Boozari, P. Schache, M.P. Manns, N.P. Malek, T. Sparwasser, L. Zender, T.C. Wirth, S. Kubicka*, and F. Kuhnel*. 2011. Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice. J Clin Invest 121:2570-2582. *equally contributed



Anz, D.*, V.H. Koelzer*, S. Moder, R. Thaler, T. Schwerd, K. Lahl, T. Sparwasser, R. Besch, H. Poeck, V. Hornung, G. Hartmann, S. Rothenfusser, C. Bourquin, and S. Endres. 2010. Immunostimulatory RNA blocks suppression by regulatory T cells. J Immunol 184:939-946. *equally contributed

Baru, A.M.*, A. Hartl*, K. Lahl, J.K. Krishnaswamy, H. Fehrenbach, A.O. Yildirim, H. Garn, H. Renz, G.M. Behrens, and T. Sparwasser. 2010. Selective depletion of Foxp3+ Treg during sensitization phase aggravates experimental allergic airway inflammation. Eur J Immunol 40:2259-2266. *equally contributed

Boissonnas, A.*, A. Scholer-Dahirel*, V. Simon-Blancal, L. Pace, F. Valet, A. Kissenpfennig, T. Sparwasser, B. Malissen, L. Fetler, and S. Amigorena. 2010. Foxp3+ T cells induce perforin-dependent dendritic cell death in tumor-draining lymph nodes. Immunity 32:266-278.*equally contributed

Engel, D.R.*, A. Koscielny*, S. Wehner, J. Maurer, M. Schiwon, L. Franken, B. Schumak, A. Limmer, T. Sparwasser, A. Hirner, P.A. Knolle, J.C. Kalff, and C. Kurts. 2010. T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract. Nat Med 16:1407-1413. *equally contributed

Hamm, S., E. Latz, D. Hangel, T. Muller, P. Yu, D. Golenbock, T. Sparwasser, H. Wagner, and S. Bauer. 2010. Alternating 2'-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist. Immunobiology 215:559-569.

Haque, A., S.E. Best, F.H. Amante, S. Mustafah, L. Desbarrieres, F. de Labastida, T. Sparwasser, G.R. Hill, and C.R. Engwerda. 2010. CD4+ natural regulatory T cells prevent experimental cerebral malaria via CTLA-4 when expanded in vivo. PLoS Pathog 6:e1001221.

Hubert, S.*, B. Rissiek*, K. Klages, J. Huehn, T. Sparwasser, F. Haag, F. Koch-Nolte, O. Boyer, M. Seman, and S. Adriouch. 2010. Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway. J Exp Med 207:2561-2568. *equally contributed

Klages, K.*, C.T. Mayer*, K. Lahl, C. Loddenkemper, M.W. Teng, S.F. Ngiow, M.J. Smyth, A. Hamann, J. Huehn*, and T. Sparwasser*. 2010. Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma. Cancer Res 70:7788-7799. *equally contributed

Pechloff, K., J. Holch, U. Ferch, M. Schweneker, K. Brunner, M. Kremer, T. Sparwasser, L. Quintanilla-Martinez, U. Zimber-Strobl, B. Streubel, A. Gewies, C. Peschel, and J. Ruland. 2010. The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma. J Exp Med 207:1031-1044.

Schildknecht, A., S. Brauer, C. Brenner, K. Lahl, H. Schild, T. Sparwasser*, H.C. Probst*, and M. van den Broek*. 2010. FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells. Proc Natl Acad Sci U S A 107:199-203. *equally contributed

Suttner, K., M. Depner, M. Wetzke, N. Klopp, E. von Mutius, T. Illig, T. Sparwasser, and M. Kabesch. 2010. Genetic variants harbored in the forkhead box protein 3 locus increase hay fever risk. J Allergy Clin Immunol 125:1395-1399.

Teng, M.W., S.F. Ngiow, B. von Scheidt, N. McLaughlin, T. Sparwasser, and M.J. Smyth. 2010. Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth. Cancer Res 70:7800-7809.



Kim, J.*, K. Lahl*, S. Hori, C. Loddenkemper, A. Chaudhry, P. deRoos, A. Rudensky, and T. Sparwasser. 2009. Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice. J Immunol 183:7631-7634. *equally contributed

Lahl, K., C.T. Mayer, T. Bopp, J. Huehn, C. Loddenkemper, G. Eberl, G. Wirnsberger, K. Dornmair, R. Geffers, E. Schmitt, J. Buer, and T. Sparwasser. 2009. Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice. J Immunol 183:5662-5672.

Pellegrini, M.*, T. Calzascia*, A.R. Elford, A. Shahinian, A.E. Lin, D. Dissanayake, S. Dhanji, L.T. Nguyen, M.A. Gronski, M. Morre, B. Assouline, K. Lahl, T. Sparwasser, P.S. Ohashi*, and T.W. Mak*. 2009. Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies. Nat Med 15:528-536. *equally contributed

Rausch, S., J. Huehn, C. Loddenkemper, M.R. Hepworth, C. Klotz, T. Sparwasser, A. Hamann, R. Lucius, and S. Hartmann. 2009. Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3+ cells. Eur J Immunol 39:3066-3077.

Siegemund, S., A. Hartl, H. von Buttlar, F. Dautel, R. Raue, M.A. Freudenberg, G. Fejer, M. Buttner, G. Kohler, C.J. Kirschning, T. Sparwasser, and G. Alber. 2009. Conventional bone marrow-derived dendritic cells contribute to toll-like receptor-independent production of alpha/beta interferon in response to inactivated parapoxvirus ovis. J Virol 83:9411-9422.

Singh, S.K., J. Stephani, M. Schaefer, H. Kalay, J.J. Garcia-Vallejo, J. den Haan, E. Saeland, T. Sparwasser, and Y. van Kooyk. 2009. Targeting glycan modified OVA to murine DC-SIGN transgenic dendritic cells enhances MHC class I and II presentation. Mol Immunol 47:164-174.

Steeg, C., G. Adler, T. Sparwasser, B. Fleischer, and T. Jacobs. 2009. Limited role of CD4+Foxp3+ regulatory T cells in the control of experimental cerebral malaria. J Immunol 183:7014-7022.

von Allmen, C.E., N. Schmitz, M. Bauer, H.J. Hinton, M.O. Kurrer, R.B. Buser, M. Gwerder, S. Muntwiler, T. Sparwasser, R.R. Beerli*, and M.F. Bachmann*. 2009. Secretory phospholipase A2-IID is an effector molecule of CD4+CD25+ regulatory T cells. Proc Natl Acad Sci U S A 106:11673-11678. *equally contributed

Zelinskyy, G., K. Dietze, T. Sparwasser, and U. Dittmer. 2009. Regulatory T cells suppress antiviral immune responses and increase viral loads during acute infection with a lymphotropic retrovirus. PLoS Pathog 5:e1000406. 

Zelinskyy, G.*, K.K. Dietze*, Y.P. Husecken, S. Schimmer, S. Nair, T. Werner, K. Gibbert, O. Kershaw, A.D. Gruber, T. Sparwasser, and U. Dittmer. 2009. The regulatory T-cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T-cell response. Blood 114:3199-3207. *equally contributed



Heit, A.*, F. Gebhardt*, K. Lahl*, M. Neuenhahn, F. Schmitz, F. Anderl, H. Wagner, T. Sparwasser*, D.H. Busch*, and K. Kastenmuller*. 2008. Circumvention of regulatory CD4(+) T cell activity during cross-priming strongly enhances T cell-mediated immunity. Eur J Immunol 38:1585-1597. *equally contributed

Osorio, F., S. LeibundGut-Landmann, M. Lochner, K. Lahl, T. Sparwasser, G. Eberl, and C. Reis e Sousa. 2008. DC activated via dectin-1 convert Treg into IL-17 producers. Eur J Immunol 38:3274-3281.

Schaefer, M.*, N. Reiling*, C. Fessler, J. Stephani, I. Taniuchi, F. Hatam, A.O. Yildirim, H. Fehrenbach, K. Walter, J. Ruland, H. Wagner, S. Ehlers*, and T. Sparwasser*. 2008. Decreased pathology and prolonged survival of human DC-SIGN transgenic mice during mycobacterial infection. J Immunol 180:6836-6845. *equally contributed



Lahl, K., C. Loddenkemper, C. Drouin, J. Freyer, J. Arnason, G. Eberl, A. Hamann, H. Wagner, J. Huehn*, and T. Sparwasser*. 2007. Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med 204:57-63. *equally contributed

Sparwasser, T., and G. Eberl. 2007. BAC to immunology--bacterial artificial chromosome-mediated transgenesis for targeting of immune cells. Immunology 121:308-313.



Gross, O., A. Gewies, K. Finger, M. Schafer, T. Sparwasser, C. Peschel, I. Forster, and J. Ruland. 2006. Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 442:651-656.

Klemm, S., J. Gutermuth, L. Hultner, T. Sparwasser, H. Behrendt, C. Peschel, T.W. Mak, T. Jakob, and J. Ruland. 2006. The Bcl10-Malt1 complex segregates Fc epsilon RI-mediated nuclear factor kappa B activation and cytokine production from mast cell degranulation. J Exp Med 203:337-347.

von Meyenn, F., M. Schaefer, H. Weighardt, S. Bauer, C.J. Kirschning, H. Wagner, and T. Sparwasser. 2006. Toll-like receptor 9 contributes to recognition of Mycobacterium bovis Bacillus Calmette-Guerin by Flt3-ligand generated dendritic cells. Immunobiology 211:557-565.



Sparwasser, T., S. Gong, J.Y. Li, and G. Eberl. 2004. General method for the modification of different BAC types and the rapid generation of BAC transgenic mice. Genesis 38:39-50.



Jung, S., D. Unutmaz, P. Wong, G. Sano, K. De los Santos, T. Sparwasser, S. Wu, S. Vuthoori, K. Ko, F. Zavala, E.G. Pamer, D.R. Littman, and R.A. Lang. 2002. In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity 17:211-220.



Baribaud, F., S. Pohlmann, T. Sparwasser, M.T. Kimata, Y.K. Choi, B.S. Haggarty, N. Ahmad, T. Macfarlan, T.G. Edwards, G.J. Leslie, J. Arnason, T.A. Reinhart, J.T. Kimata, D.R. Littman, J.A. Hoxie, and R.W. Doms. 2001. Functional and antigenic characterization of human, rhesus macaque, pigtailed macaque, and murine DC-SIGN. J Virol 75:10281-10289.



Decker, T., F. Schneller, T. Sparwasser, T. Tretter, G.B. Lipford, H. Wagner, and C. Peschel. 2000. Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production, and an immunogenic phenotype in chronic lymphocytic leukemia B cells. Blood 95:999-1006.

Lipford, G.B., T. Sparwasser, S. Zimmermann, K. Heeg, and H. Wagner. 2000. CpG-DNA-mediated transient lymphadenopathy is associated with a state of Th1 predisposition to antigen-driven responses. J Immunol 165:1228-1235.

Sparwasser, T., R.M. Vabulas, B. Villmow, G.B. Lipford, and H. Wagner. 2000. Bacterial CpG-DNA activates dendritic cells in vivo: T helper cell-independent cytotoxic T cell responses to soluble proteins. Eur J Immunol 30:3591-3597.



Sparwasser, T., L. Hultner, E.S. Koch, A. Luz, G.B. Lipford, and H. Wagner. 1999. Immunostimulatory CpG-oligodeoxynucleotides cause extramedullary murine hemopoiesis. J Immunol 162:2368-2374.



Hacker, H., H. Mischak, T. Miethke, S. Liptay, R. Schmid, T. Sparwasser, K. Heeg, G.B. Lipford, and H. Wagner. 1998. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J 17:6230-6240.

Heeg, K., T. Sparwasser, G.B. Lipford, H. Hacker, S. Zimmermann, and H. Wagner. 1998. Bacterial DNA as an evolutionary conserved ligand signalling danger of infection to immune cells. Eur J Clin Microbiol Infect Dis 17:464-469.

Sparwasser, T.*, E.S. Koch*, R.M. Vabulas, K. Heeg, G.B. Lipford, J.W. Ellwart, and H. Wagner. 1998. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur J Immunol 28:2045-2054. *equally contributed



Lipford, G.B., T. Sparwasser, M. Bauer, S. Zimmermann, E.S. Koch, K. Heeg, and H. Wagner. 1997. Immunostimulatory DNA: sequence-dependent production of potentially harmful or useful cytokines. Eur J Immunol 27:3420-3426.

Sparwasser, T., T. Miethke, G. Lipford, K. Borschert, H. Hacker, K. Heeg, and H. Wagner. 1997. Bacterial DNA causes septic shock. Nature 386:336-337.

Sparwasser, T., T. Miethke, G. Lipford, A. Erdmann, H. Hacker, K. Heeg, and H. Wagner. 1997. Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-alpha-mediated shock. Eur J Immunol 27:1671-1679.



Honours and Awards


Dagmar Eißner Award

Ayesha Dhillon-LaBrooy


Call for a W2 professorship, Institute for Molecular Medicine

Dr. Luciana Berod

2020 to date

Member Senate Committee on Internationalization (JGU Mainz)

Member Senate Committee on Internationalization (JGU Mainz)


Member of the DGfI Advisory Board 2nd period of office

Prof. Dr. Tim Sparwasser


German representative of the International Council of Immunologists (IUIS)

Prof. Dr. Tim Sparwasser

2018 to date

Member Steering committee FZI (JGU Mainz)

Prof. Dr. Tim Sparwasser


Call for a W3 professorship / Chair Institute for Medical Microbiology and Hygiene (IMMH), JGU Mainz

Prof. Dr. Tim Sparwasser


Robert Koch Postoctoral Prize in Immunology

Dr. Christian Thomas Mayer


Early Career Research Prize in Vaccinology (IUIS)

Dr. Christian Thomas Mayer


MHH HILF PostDoc Research Funding

Dr. Jenny Kühne

2018 to date

Associate Researcher Center for Research in Inflammatory Diseases – CRID Ribeirao Preto Medical School, University of Sao Paulo CRID Ribeirao Preto Medical School, University of Sao Paulo

Prof. Dr. Tim Sparwasser


Call for a W3 professorship, Institute for Medical Microbiology and Virology, TU Dresden (declined)

Prof. Dr. Tim Sparwasser


MHH Promotion Award

Dr. Marc Lindenberg


DZIF MD-PhD Scholarship

Dr. Marc Lindenberg


HZI Paper of the month

Marcela Francoso/ Dr. Franz Puttur


Lundbeck Award

Dr. Katharina Lahl


Jürgen-Wehland Award

Dr. Luciana Berod


DAAD Scholarship

Dr. Lis Velasquez


HZI Paper of the month

Markus Dudek


EMBO Scholarship

Dr. Carlos Bueno


DAAD Short-term Scholarship

Lais Sacramento


DAAD Short-term Scholarship

Paulo Melo


FAPESP Scholarship (Sabbatical)

Prof. Dr. Vania Bonato

2016 to date

Chairman DGfI Jury of Fritz -and Ursula Melcher Award

Prof. Dr. Tim Sparwasser



Prof. Dr. Tim Sparwasser


Ellen-Schmidt Habil. Scholarship

Dr. Luciana Berod


Boehringer Ingelheim Foundation

Lucia Minarrieta


DAAD Scholarship

Brenda Raud


Ragnar Söderberg Fellowship in Medicine

Dr. Katharina Lahl


EMBO Fellowship

Dr. Christian Thomas Mayer


Guest professor Microbiology and Infection Immunology, Facultad de Medicina, Universidad Catolica de Cordoba, Argentina

Prof. Dr. Tim Sparwasser


Fritz- und Ursula Melchers DGfI Postdoc award

Dr. Christian Thomas Mayer


Poster award/ Travel grant (Seahorse)

Dr. Luciana Berod


HZI Paper of the month

Dr. Catharina Arnold-Schrauf


HZI Paper of the month

Peyman Ghorbani


HZI Paper of the month

Dr. Luciana Berod


MHH HILF PostDoc Research Funding

Dr. Luciana Berod


Member of the DGfI Advisory Board 1st period of office

Prof. Dr. Tim Sparwasser


Member of the International Council of Hannover Medical School

Prof. Dr. Tim Sparwasser


HZI Inhoffen Award

Dr. Christian Thomas Mayer


MHH HILF PostDoc Research Funding

Dr. Franz Puttur


HZI Paper of the month

Dr. Franz Puttur


Ciência sem fronteiras CAPES Scholarship

Marcela Francozo


Fulbright Scholarship

Aline Sandouk


TUI Habilitation Award

Dr. Matthias Lochner


HZI Paper of the month

Dr. Matthias Lochner


Boehringer Ingelheim Foundation PhD Fellowship

Catharina Arnold-Schrauf


DAAD PhD Fellowship

Amrita Nandan


Advisory Board Member of GRK 1660

Prof. Dr. Tim Sparwasser


PhD Scholarship German National Academic Foundation

Christian Thomas Mayer


Board member of the Collaborative Research Center SFB 587

Prof. Dr. Tim Sparwasser


Call for a W3 professorship for Infection Immunology (TWINCORE, a joint venture between Hannover Medical School and Helmholtz Center for Infection Research), Hannover

Prof. Dr. Tim Sparwasser


Board member of the TR 22

Prof. Dr. Tim Sparwasser


DGHM Young Investigator Award (German Society of Microbiology & Hygiene)

Dr. Tim Sparwasser


HHMI Postdoctoral Fellowship Award for Physicians

Dr. Tim Sparwasser


Scholarship German National Academic Foundation

Tim Sparwasser


Luís P Almeida

Master Thesis, Medical Biochemistry, German-Argentinean AMIBA Master Program in Infection Biology at TWINCORE/Medizinische Hochschule Hannover (MHH) (2019)
currently: PhD student, Immunoparasitology with Maria Yazdanbakhsh, Leiden University Medical Center, Leiden, Netherlands

Jon Arnason
DAAD scholarship as “visiting student” (2002-2003)
afterwards: Hematology Oncology Fellow at Weill Cornell Medical Center New York City
currently: MD, Beth Israel Deaconess Medical Center of Boston, USA

Catharina Arnold-Schrauf
PhD scholarship holder of Boehringer Ingelheim foundation (2010-2014); PhD at TWINCORE/MHH and Postdoctoral Fellow SFB 900 (2014-2015)
afterwards: Postdoctoral Fellow, Centre d’ Immunologie de Marseille with Marc Dalod, Marseille, France
currently: Medical Affairs Specialist, Hematology/Oncology at Celgene in Vienna, Austria

Abdul Mannan Baru
Postdoctoral Fellow at TWINCORE/MHH (2009-2012)
afterwards: Postdoctoral Fellow in Molecular and Translational Cardiology with Kai C. Wollert
currently: Scientific Leader, GlaxoSmithKline Pharma GmbH, Stevenage, United Kingdom

Luciana Berod
Postdoctoral Fellow and Group leader at TWINCORE, a joint venture of MHH and Helmholtz Centre for Infection Research (HZI) (2010-2020)
currently: W2 Professor at the Institute for Molecular Medicine, Universitätsmedizin, Johannes Gutenberg University Mainz

Carla Castro
Postdoctoral Fellow at TWINCORE/MHH (2013-2016)
currently: Postdoctoral Fellow, Center for Chronic Immundeficency (CCI) with Stephan Ehl, University Medical Center Freiburg

Andrea Classen
Master Thesis, Biochemistry at LMU Munich (2003-2004)
recently: PhD, Macrophage Biology with Antonio Celada, Institute for Research in Biomedicine, University of Barcelona, Spain

Daniela Dittlein
Bachelor Thesis, Biochemistry at TU Munich (2007); PhD at TUM
currently: Scientific Advisor to the CEO, Helmholtz Center Munich

Markus Dudek
PhD scholarship holder of IRTG 1273 (2011-2016); PhD at TWINCORE/MHH
afterwards: Postdoctoral Fellow at Center for Thrombosis und Haemostasis (CTH) with Markus Bosmann, University Medical Center Mainz
currently: Scientist, Translational Biomarkers, Sanofi, Frankfurt am Main

Theresa Förg
Doctoral student in Medicine at TU Munich (TUM)/TWINCORE (2009); Scholarship holder Studienstiftung des deutschen Volkes; MD at TUM
currently: Medical Specialist, Pediatric Clinic and Pediatric Polyclinic, LMU Munich

Marcela Francozo
DAAD/CAPES PhD scholarship holder, PhD student (2013-2017) and Postdoctoral Fellow at TWINCORE/MHH (2018-2019)
currently: Assistant Project Manager, Vakzine Project Management GmbH, Hannover

Christin Friedrich
PhD student, DFG funded, PhD at TWINCORE/MHH (2011-2014)
afterwards: Postdoctoral Fellow with Georg Gasteiger at the Johannes Gutenberg-University Mainz
currently: Postdoctoral Fellow, Institute for Systems Immunology with Georg Gasteiger, University Würzburg

Venkateswaran Ganesh
PhD scholarship holder at the Molecular Medicine PhD Program (2009-2013); PhD at TWINCORE/MHH
afterwards: Research Scientist, Pfizer, Chennai, India
currently: Associate Manager, Program Management, Biocon, Bengaluru Area, India

Maria Virginia Gentilini
Postdoctoral Fellow SFB 900 (2015-2016)
currently: Lecturer at the University of Buenos Aires and Postdoctoral scholarship, CONICET, University Medical Center  "José de San Martín" in Buenos Aires, Argentina

Peyman Ghorbani
PhD student, Center for Infectious Biology (ZIB), PhD at TWINCORE/MHH (2012-2017)
currently: Postdoctoral Fellow, University of Ottawa with Morgan Fullerton, Canada

Wiebke Ginter
PhD scholarship holder of Center for Infectious Biology (ZIB) (2009-2013); PhD at TWINCORE/MHH
afterwards: Scientific coordinator of LISA Summer Academy and AMIBA Master Program
currently: Consultant Science Management, Deutsche Forschungsgemeinschaft (DFG), Bonn

Naghmeh Goharani
Doctoral student in Medicine, “StrucMed” TWINCORE/MHH (2012-2014); MD at MHH

Stefanie Hagemann
PhD scholarship holder KFO250 (2010-2013); PhD at TWINCORE/MHH
currently: Postdoctoral Fellow with Siegfried Hapfelmeier at Institute for Infectious diseases, University Bern, Switzerland

Andrea Hartl
PhD student Biology (2004-2009) and PhD at TU Munich
currently: Team Leader Crime/Project Manager/LIMS Administrator, Eurofins Medigenomix Forensik GmbH, Ebersberg

Karen Patricia Hartmann
Student assistant (2013-2014); Bachelor Thesis, Biomedicine at Leibniz University Hannover and TWINCORE (2013-2013)
afterwards: Employee at the Paul-Ehrlich-Institute in Langen, Molecular Biotechnology and Gene Therapy with Christian Buchholz
currently: PhD Student at the University of Zürich, Department of Biochemistry, Zurich, Switzerland

Siona Hauer
Doctoral student in Medicine, StrucMed/MHH (2010-2011); MD at MHH

Christina Hesse
PhD scholarship holder International Research Training Groups 1441 (2010-2014); PhD and Postdoctoral Fellow at TWINCORE/MHH (2015)
afterwards: Postdoctoral Fellow Fraunhofer with Armin Braun at Institute for Toxicology and Experimental Medicine (ITEM)
currently: Group leader „Respiratory Pharmcology“, Department of Preclinical Pharmacology and In Vitro Toxicology at ITEM, Hannover

Susanne Hipp
Bachelor Thesis, Biochemistry at TU Munich (2004)

Julia Huntenburg
Bachelor Thesis, Life Sciences at Leibnitz University Hannover and TWINCORE/MHH, Scholarship holder Studienstiftung des Deutschen Volkes (2010)
afterwards: Master Program Molecular Medicine, Charité Berlin
currently: PhD student at Max-Planck Institute for Human Cognitive and Brain Sciences, Leipzig

Inga Jensch
Master Thesis, Biology at TU Munich (2004-2005); PhD Microbiology with Sven Hammerschmidt, University Greifswald
currently: Postdoctoral Fellow with Matthias Hundt at the ZIK HIKE, University of Greifswald

Stefan Jordan
Master Thesis, Biochemistry at TU Munich (2006); Scholarship holder of the Studienstiftung des deutschen Volkes; PhD with Ulrich Koszinowski, Max von Pettenkofer-Institute at LMU
afterwards: Postdoctoral Fellow with Miriam Merad, New York Mount Sinai School of Medicine, USA
currently: Group leader, Institute for Microbiology and Infection Immunology, Charité Berlin

Wilhelm Korte
Doctoral student in Medicine, StrucMed/MHH (2011-2012)
recently: Assistant Physician in Heart Surgery at MHH

Freyja Kull
Doctoral student in Medicine, StrucMed/MHH (2013)

Katharina Lahl
Diploma Thesis (2004-2005) and PhD student at TU Munich (2005-2009)
afterwards: Postdoctoral Fellow, Stanford University with Eugene Butcher, Palo Alto, USA
currently: Group leader and Associate Professor, DTU Health Tech, Technical University Denmark and Divison Virus Recognition, Lund University, Sweden

Marc Lindenberg
MD student (2012-2013); MD/PhD at MHH (2018-2020)

Matthias Lochner
Group leader, then Associate Professor (PD) at TWINCORE/MHH (2010-2020), currently Associate Professor at the Department for Medical Microbiology, MHH

Christian Mayer
Master Thesis, Biochemistry at TU Munich (2007-2008), PhD scholarship holder Studienstiftung des deutschen Volkes, PhD (2008-2012) and Postdoctoral fellow at TWINCORE/MHH (2012-2013)
afterwards: Postdoctoral Fellow with Michel Nussenzweig, Rockefeller University, New York, USA
currently: NIH Stadtman Investigator at the Experimental Immunology Branch, National Cancer Institute, Bethesda, USA

Lucia Minarrieta
PhD scholarship holder of Boehringer Ingelheim foundation, PhD student, Center for Infectious Biology (ZIB) at TWINCORE/MHH (2014-2018)
currently: Postdoctoral Fellow with Julie St-Pierre, University of Ottawa, Canada

Mercedes Muske
Master Thesis at TWINCORE/MHH (2014-2015)

Amrita Nandan
DAAD PhD scholarship holder, PhD at MHH (2010-2014)
currently: Project Scientist, Institute of Genomics and Integrative Biology (IGIB), CSIR, India

Franz Puttur
Postdoctoral Fellow at TWINCORE/MHH (2010-2016)
currently: Postdoctoral Fellow at the Imperial College, National Heart and Lung Institute with Clare Lloyd, Faculty of Medicine, in London, United Kingdom

Brenda Raud
DAAD PhD scholarship holder, PhD student at TWINCORE/MHH (2014-2018)
currently: Postdoctoral Fellow with John Haanen, Division of Molecular Oncology and Immunology, Netherlands Cancer Institute, Amsterdam, Netherlands

Martin Schäfer
PhD student Biology at TU Munich (2003-2006); PhD at TU Munich
currently: Research Scientist Bioanalytics, Roche Diagnostics GmbH in Penzberg

Gülhas Solmaz
PhD scholarship holder of Center for Infectious Biology (ZIB) (2011-2016); PhD at TWINCORE/MHH
recently: Postdoctoral Fellow with Fahrettin Kelestemur at the Turkish Health Department, Ankara, Turkey

Johannes Stephani
Doctoral student in Medicine at TU Munich (2006-2008); MD at TU Munich
currently: Intern, Internal Medicine, University Medical Center Ulm

Philipp Stüve
Master Thesis (2013) and PhD (2013-2017) at TWINCORE/MHH
currently: Postdoctoral Fellow at IMMH, Universitätsmedizin, Johannes Gutenberg University Mainz

Lena Thöle
Master Thesis, Biochemistry at TWINCORE/MHH, scholarship holder Studienstiftung des deutschen Volkes (2016)
currently: Medical student at MHH

Christopher Untucht
Postdoctoral Fellow (2011-2012)
afterwards: Postdoctoral Fellow at AbbVie Germany GmbH & Co KG
currently: Senior Scientist II Abbvie, Ludwigshafen

Christopher van Helt
Master Thesis, Biomedicine at TWINCORE/MHH (2010)
afterwards: PhD student at Beiersdorf, Division Experimental Toxikology
currently: QA Manager Release, Sandoz, Austria

Ferdinand von Meyenn
Master Thesis, Biochemistry - TU Munich (2005-2006); PhD, Institute of Molecular Systems Biology with Markus Stoffel, ETH Zurich
afterwards: Postdoctoral Fellow with Wolfgang Reik, University of Cambridge
currently: Assistant Professor, Laboratory of Nutrition and Metabolic Epigenetics, ETH Zurich, DHEST, Austria

Zuobai Wang
PhD scholarship holder at the "Center for Infection Biology“ (2010-2014); PhD at TWINCORE/MHH
currently: Postdoctoral Fellow at BeiGene, Beijing, China

Vera Wenzel
Bachelor Thesis -TU Munich (2007); PhD at TU Munich
currently: Medical Lead Education Solutions, coliquio