Publikation List Prof. Dr. Christian Behl



Schmitt D, Bozkurt S, Henning-Domres P, Huesmann H, Eimer S, Bindila L, Behrends C, Boyle E, Wilfling F, Tascher G, Münch C, Behl C, Kern A. (2023).
FACS-mediated isolation of native autophagic vesicles. Autophagy. 19(7):2146-2147.



Schmitt D, Bozkurt S, Henning-Domres P, Huesmann H, Eimer S, Bindila L, Behrends C, Boyle E, Wilfling F, Tascher G, Münch C, Behl C, Kern A. (2022).
Lipid and protein content profiling of isolated native autophagic vesicles.
EMBO Rep. 23(12):e53065.

Chillappagari S, Schwarz J, Kesireddy V, Knoell J, Korfei M, Hoetzenecker K, Schmitz ML, Behl C, Bellusci S, Guenther A, Mahavadi P. Therapeutic induction of Bcl2-associated athanogene 3-mediated autophagy in idiopathic pulmonary fibrosis.
Clin Transl Med. 12(7):e935.

Schweiger L, Lelieveld-Fast LA, Mikuličić S, Strunk J, Freitag K, Tenzer S, Clement AM, Florin L. (2022).
HPV16 Induces Formation of Virus-p62-PML Hybrid Bodies to Enable Infection.
Viruses. 5;14(7):1478.

Baeken MW, Behl C.
On the origin of BAG(3) and its consequences for an expansion of BAG3's role in protein homeostasis. J Cell Biochem. 123(1):102-114.



Colombo E, Horta G, Roesler MK, Ihbe N, Chhabra S, Radyushkin K, Di Liberto G, Kreutzfeldt M, Schumann S, von Engelhardt J, Merkler D, Behl C, Mittmann T, Clement AM, Waisman A, Schmeisser MJ.
The K63 deubiquitinase CYLD modulates autism-like behaviors and hippocampal plasticity by regulating autophagy and mTOR signaling.
Proc Natl Acad Sci U S A. 23;118(47):e2110755118.

Behl C. (2021) Integrity measures take its toll: Introducing a complete supplement issue with retractions only.
J Cell Biochem. 122 Suppl 1:S7.

Baeken MW, Schwarz M, Kern A, Moosmann B, Hajieva P, Behl C. (2021)
The selective degradation of sirtuins via macroautophagy in the MPP+ model of Parkinson's disease is promoted by conserved oxidation sites.
Cell Death Discov. 2021 Oct 12;7(1):286.

Basic M, Hertel A, Bajdzienko J, Bonn F, Tellechea M, Stolz A, Kern A, Behl C, Bremm A. (2021)
The deubiquitinase USP11 is a versatile and conserved regulator of autophagy.
J Biol Chem. 297(5):101263.

Klionsky DJ, (…), Behl C, (…), Kern A, et al. (2021)
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).
Autophagy. 17(1):1-382.

Behl C. (2021)
Science integrity has been never more important: It's all about trust.
J Cell Biochem. 122(7):694-695.

chepers J, Behl C. (2021)
Lipid droplets and autophagy-links and regulations from yeast to humans.
J Cell Biochem. 122(6):602-611.

Behl C. (2021)
The search for novel targets in Alzheimer's disease-The 90s redux.
Prog Mol Biol Transl Sci. 177:123-135.

Besemer AS, Maus J, Ax MDA, Stein A, Vo S, Freese C, Nalbach K, von Hilchen C, Pfalzgraf IF, Koziollek-Drechsler I, Silva B, Huesmann H, Boukhallouk F, Florin L, Kern A, Behl C, Clement AM.
Receptor-mediated endocytosis 8 (RME-8)/DNAJC13 is a novel positive modulator of autophagy and stabilizes cellular protein homeostasis.
Cell Mol Life Sci. 78(2):645-660.



Blawat K, Mayr A, Hardt M, Kirschneck C, Nokhbehsaim M, Behl C, Deschner J, Jäger A, Memmert S. (2020).
Regulation of Autophagic Signaling by Mechanical Loading and Inflammation in Human PDL Fibroblasts.
Int J Mol Sci. 11;21(24):9446.

Hiebel C, Stürner E, Hoffmeister M, Tascher G, Schwarz M, Nagel H, Behrends C, Münch C, Behl C. (2020).
BAG3 Proteomic Signature under Proteostasis Stress.
Cells. 2020 Nov 4;9(11):2416.

Baeken MW, Weckmann K, Diefenthäler P, Schulte J, Yusifli K, Moosmann B, Behl C, Hajieva P. (2020).
Novel Insights into the Cellular Localization and Regulation of the Autophagosomal Proteins LC3A, LC3B and LC3C.
Cells. 18;9(10):2315.

Kern A, Behl C. (2020).
On-demand autophagic network adaptations upon limited lipid availability.
Autophagy. 16(7):1348-1350. Kögel D, Linder B, Brunschweiger A, Chines S, Behl C. (2020).
At the Crossroads of Apoptosis and Autophagy: Multiple Roles of the Co-Chaperone BAG3 in Stress and Therapy Resistance of Cancer.
Cells. 28;9(3):574.

Christ MG, Clement AM, Behl C. (2020).
The Sigma-1 Receptor at the Crossroad of Proteostasis, Neurodegeneration, and Autophagy. Trends Neurosci. 43(2):79-81.

Bekbulat F, Schmitt D, Feldmann A, Huesmann H, Eimer S, Juretschke T, Beli P, Behl C, Kern A. (2020).
RAB18 Loss Interferes With Lipid Droplet Catabolism and Provokes Autophagy Network Adaptations.
J Mol Biol. 14;432(4):1216-1234. Epub 2019.



Kern A, Behl C. (2019).
Special Issue on "Proteostasis and Autophagy".
Cells. 26;8(7):642

Feldmann LK, Le Prieult F, Felzen V, Thal SC, Engelhard K, Behl C, Mittmann T. (2019). Proteasome and Autophagy-Mediated Impairment of Late Long-Term Potentiation (l-LTP) after Traumatic Brain Injury in the Somatosensory Cortex of Mice.
Int J Mol Sci. 20(12):3048.

Chakraborty D, Felzen V, Hiebel C, Stürner E, Perumal N, Manicam C, Sehn E, Grus F, Wolfrum U, Behl C. (2019).
Enhanced autophagic-lysosomal activity and increased BAG3-mediated selective macroautophagy as adaptive response of neuronal cells to chronic oxidative stress.
Redox Biol.;24:101181.

van Well EM, Bader V, Patra M, Sánchez-Vicente A, Meschede J, Furthmann N, Schnack C, Blusch A, Longworth J, Petrasch-Parwez E, Mori K, Arzberger T, Trümbach D, Angersbach L, Showkat C, Sehr DA, Berlemann LA, Goldmann P, Clement AM, Behl C, Woerner AC, Saft C, Wurst W, Haass C, Ellrichmann G, Gold R, Dittmar G, Hipp MS, Hartl FU, Tatzelt J, Winklhofer KF. (2019).
A protein quality control pathway regulated by linear ubiquitination.
EMBO J. 38(9):e100730.

Christ MG, Huesmann H, Nagel H, Kern A, Behl C. (2019).
Sigma-1 Receptor Activation Induces Autophagy and Increases Proteostasis Capacity In Vitro and In Vivo.
Cells. 2;8(3):211.





Kern A, Spang N, Huesmann H, Behl C. (2018)
Novel Modulators of Proteostasis: RNAi Screen of Chromosome I in a Heat Stress Paradigm in C. elegans.
Cells. 26;7(6).

Weckmann K, Diefenthäler P, Baeken MW, Yusifli K, Turck CW, Asara JM, Behl C, Hajieva P.
Metabolomics profiling reveals differential adaptation of major energy metabolism pathways associated with autophagy upon oxygen and glucose reduction.
Sci Rep. 5;8(1):2337.

Windschmitt J., Jacobi B., Buelbuel Y., Sester L., Tappe J., Hiebel C., Behl C., Theobald M., Munder M. (2018)
Arginine Depletion in Combination with Canavanine Supplementation Induces Massive Cell Death in Myeloma Cells By Interfering with Their Protein Metabolism and Bypassing Potential Rescue Mechanisms.
Blood. 132(S1):3205




Sebastiani A, Gölz C, Sebastiani PG, Bobkiewicz W, Behl C, Mittmann T, Thal SC, Engelhard K (2017).
Sequestosome 1 Deficiency Delays, but Does Not Prevent Brain Damage Formation Following Acute Brain Injury in Adult Mice.
Front Neurosci. 19;11:678.

Behl C, Ziegler C (2017).
Beyond Amyloid - Widening the View on Alzheimer's Disease.
J Neurochem. 143(4):394-395

Behl C (2017).
Amyloid in Alzheimer's Disease: Guilty Beyond Reasonable Doubt?
Trends Pharmacol Sci. 38(10):849-851.

Reilly R, Mroz MS, Dempsey E, Wynne K, Keely SJ, McKone EF, Hiebel C, Behl C, Coppinger JA (2017).
Targeting the PI3K/Akt/mTOR signalling pathway in Cystic Fibrosis.
Sci Rep. 7(1):7642.

Stürner E, Behl C (2017).
The Role of the Multifunctional BAG3 Protein in Cellular Protein Quality Control and in Disease.
Front Mol Neurosci. 10:177.

Feldmann A, Bekbulat F, Huesmann H, Ulbrich S, Tatzelt J, Behl C, Kern A (2017).
The RAB GTPase RAB18 modulates macroautophagy and proteostasis.
Biochem Biophys Res Commun. 486(3):738-743.

Schönbühler B, Schmitt V, Huesmann H, Kern A, Gamerdinger M, Behl C (2017).
BAG2 Interferes with CHIP-Mediated Ubiquitination of HSP72.
Int. J. Mol. Sci. 18(1), 69.



Behl C (2016).
Breaking BAG: The Co-Chaperone BAG3 in Health and Disease.
Trends Pharmacol Sci. 37(8):672-88.

Rodríguez AE, López-Crisosto C, Peña-Oyarzún D, Salas D, Parra V, Quiroga C, Morawe T, Chiong M, Behl C, Lavandero S (2016).
BAG3 regulates total MAP1LC3B protein levels through a translational but not transcriptional mechanism.
Autophagy. 12(2):287-96.

Klionsky DJ, (...), Behl C, (...), Kern A, et al. (2016).
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy. 12(1):1-222.

Khaminets A, Behl C, Dikic I (2016).
Ubiquitin-Dependent And Independent Signals In Selective Autophagy.
Trends Cell Biol. 26(1):6-16.

Kundu A, Milosch N, Antonietti P, Baumkötter F, Zymny A, Müller UC, Kins S, Hajieva P, Behl C, Kögel D (2015).
Modulation of BAG3 Expression and Proteasomal Activity by sAPPα Does Not Require Membrane-Tethered Holo-APP.
Mol Neurobiol. 53(9):5985-5994.



Kern A, Dikic I, Behl C (2015).
The integration of autophagy and cellular trafficking pathways via RAB GAPs.
Autophagy. 11(12):2393-7.

Felzen V, Hiebel C, Koziollek-Drechsler I, Reißig S, Wolfrum U, Kögel D, Brandts C, Behl C, Morawe T (2015).
Estrogen receptor α regulates non-canonical autophagy that provides stress resistance to neuroblastoma and breast cancer cells and involves BAG3 function.
Cell Death Dis. 6:e1812.

Hiebel C, Behl C (2015).
The complex modulation of lysosomal degradation pathways by cannabinoid receptors 1 and 2.
Life Sci. 2015 Apr 20. [Epub ahead of print]

Meister S, Storck SE, Hameister E, Behl C, Weggen S, Clement AM, Pietrzik CU (2015).
Expression of the ALS-causing variant hSOD1G93A leads to an impaired integrity and altered regulation of claudin-5 expression in an in vitro blood-spinal cord barrier model.
J Cereb Blood Flow Metab. 35(7):1112-21.

Liebl MP, Windschmitt J, Besemer AS, Schäfer AK, Reber H, Behl C, Clement AM (2015).
Low-frequency magnetic fields do not aggravate disease in mouse models of Alzheimer's disease and amyotrophic lateral sclerosis.
Sci Rep. 5:8585.

Granold M, Moosmann B, Staib-Lasarzik I, Arendt T, Del Rey A, Engelhard K, Behl C, Hajieva P (2015).
High membrane protein oxidation in the human cerebral cortex.
Redox Biol. 4:200-7.

Renziehausen J, Hiebel C, Nagel H, Kundu A, Kins S, Kögel D, Behl C, Hajieva P (2015).
The Cleavage Product of Amyloid-β Protein Precursor sAβPPα Modulates BAG3-Dependent Aggresome Formation and Enhances Cellular Proteasomal Activity.
J Alzheimers Dis. 44(3):879-96.

Pasillas MP, Shields S, Reilly R, Strnadel J, Behl C, Park R, Yates JR 3rd, Klemke R, Gonias SL, Coppinger JA (2015).
Proteomic analysis reveals a role for Bcl2-associated athanogene 3 and Major Vault Protein in resistance to apoptosis in senescent cells by regulating ERK1/2 activation.
Mol Cell Proteomics. 14(1):1-14.

Hajieva P, Bayatti N, Granold M, Behl C, Moosmann B (2015)
Membrane protein oxidation determines neuronal degeneration.
J Neurochem. 133(3):352-67.



Spang N*, Feldmann A*, Huesmann H, Bekbulat F, Schmitt V, Hiebel C, Koziollek-Drechsler I, Clement AM, Moosmann B, Jung J, Behrends C, Dikic I, Kern A, Behl C (2014) (* equal contribution)
RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy.
Autophagy. 10(12):2297-309.

Milosch N, Tanriöver G, Kundu A, Rami A, François JC, Baumkötter F, Weyer SW, Samanta A, Jäschke A, Brod F, Buchholz CJ, Kins S, Behl C, Müller UC, Kögel D (2014).
Holo-APP and G-protein-mediated signaling are required for sAPPα-induced activation of the Akt survival pathway.
Cell Death Dis. 5:e1391.

Hiebel C, Kromm T, Stark M, Behl C (2014).
Cannabinoid receptor 1 modulates the autophagic flux independent of mTOR- and BECLIN1-complex.
J Neurochem. 131(4): 484-97.

Stark M, Behl C (2014).
The Ginkgo biloba Extract EGb 761 Modulates Proteasome Activity and Polyglutamine Protein Aggregation.
Evidence-Based Complementary and Alternative Medicine 2014:940186.

Liebl MP, Kaya AM, Tenzer S, Mittenzwei R, Koziollek-Drechsler I, Schild HR, Moosmann B, Behl C, Clement AM (2014).
Dimerization of visinin-like protein 1 is regulated by oxidative stress and calcium and is a pathological hallmark of amyotrophic lateral sclerosis.
Free Radic Biol Med. 72:41-54.

Brendel A, Renziehausen J, Behl C, Hajieva P (2014).
Downregulation of PMCA2 increases the vulnerability of midbrain neurons to mitochondrial complex I inhibition.
Neurotoxicology 40:43-51.



Weichert A, Besemer AS, Liebl M, Hellmann N, Koziollek-Drechsler I, Ip P, Decker H, Robertson J, Chakrabartty A, Behl C, Clement AM (2013).
Wild-type Cu/Zn superoxide dismutase stabilizes mutant variants by heterodimerization.
Neurobiol Dis. 62:479-488.

Blödt S, Kuhlmey A, Bartholomeyczik S, Behl C, Betsch F, Brinkhaus B, Frühwald M, Füsgen I, Jansen S, Köppel C, Krüger E, Macher M, Michalsen A, Rapp MA, Riepe MW, Schimpf D, Teut M, Warme B, Warning A, Wilkens J, Witt CM (2013).
Dementia in Germany: Results of an interdisciplinary expert workshop.
Wien Med Wochenschr. 163:536-40. German.

Stumm C, Hiebel C, Hanstein R, Purrio M, Nagel H, Conrad A, Lutz B, Behl C, Clement AB (2013).
Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition.
Neurobiol Aging. 34(11): 2574-84.

Brendel A, Felzen V, Morawe T, Manthey D, Behl C (2013).
Differential regulation of apoptosis-associated genes by estrogen receptor alpha in human neuroblastoma cells.
Restor Neurol Neurosci. 31: 199-211.

Korac J, Schaeffer V, Kovacevic I, Clement AM, Jungblut B, Behl C, Terzic J, Dikic I (2013).
Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates.
J Cell Sci. 126: 580-92.



Büchner B, Gallenmüller C, Lautenschläger R, Kuhn K, Wittig I, Schöls L, Rapaport D, Seelow D, Freisinger P, Prokisch H, Sperl W, Wenz T, Behl C, Deschauer M, Kornblum C, Schneiderat P, Abicht A, Schuelke M, Meitinger T, Klopstock T und und das mitoNET-Consortium (2012).
Das Deutsche Netzwerk für mitochondriale Erkrankungen (mitoNET).
Medizinische Genetik 24: 193-199.

Klionsky DJ, (...), Behl C, (...) (2012).
Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy 8: 445-544.

Behl C (2012).
Brain aging and late-onset Alzheimer's disease: many open questions.
Int Psychogeriatr. 24 Suppl 1: S3-9.

Morawe T, Hiebel C, Kern A, Behl C (2012).
Protein Homeostasis, Aging and Alzheimer's Disease.
Mol Neurobiol. 46(1):41-54.

Kögel D, Deller T, Behl C (2012).
Roles of amyloid precursor protein family members in neuroprotection, stress signaling and aging.
Exp Brain Res. 217:471-9.



Gamerdinger M, Carra S, Behl C (2011)
Emerging roles of molecular chaperones and co-chaperones in selective autophagy: focus on BAG proteins.
J Mol Med (Berl). 89:1175-82.

Behl C (2011)
BAG3 and friends: Co-chaperones in selective autophagy during aging and disease.

Autophagy 7(7):795-8.

Schindeldecker M, Stark M, Behl C, Moosmann B (2011)
Differential cysteine depletion in respiratory chain complexes enables the distinction of longevity from aerobicity.
Mech. Ageing Dev. 132:171-179.

Gamerdinger M, Kaya AM, Wolfrum U, Clement AM, Behl C (2011)
BAG3 mediates chaperone-based aggresome-targeting and selected autophagy of misfolded proteins.
EMBO Rep. 12(2):149-56.



Mocko JB, Kern A, Moosmann B, Behl C, Hajieva P (2010)
Phenothiazines interfere with dopaminergic neurodegeneration in Caenorhabditis elegans models of Parkinson's disease.
Neurobiol Dis 40(1): 120-9.

Haege S, Galetzka D, Zechner U, Haaf T, Gamerdinger M, Behl C, Hiemke C, Schmitt U (2010)
Spatial learning and expression patterns of PP1 mRNA in mouse hippocampus.
Neuropsychobiology 61(4): 188-96.

Clement AB, Gimpl G, Behl C (2010)
Oxidative stress resistance in hippocampal cells is associated with altered membrane fluidity and enhanced nonamyloidogenic cleavage of endogenous amyloid precursor protein.
Free Radic Biol Med 48(9): 1236-1241.

Luh C, Kuhlmann CR, Ackermann B, Timaru-Kast R, Luhmann HJ, Behl C, Werner C, Engelhard K, Thal SC (2010)
Inhibition of myosin light chain kinase reduces brain edema formation after traumatic brain injury.
J Neurochem 112(4): 1015-1025.

Manthey D, Gamerdinger M, Behl C (2010)
The selective beta1-adrenoceptor antagonist nebivolol is a potential oestrogen receptor agonist with neuroprotective abilities.
Br J Pharmacol 159(6): 1264-1273.

Kern A, Ackermann B, Clement, AM, Dürk H, Behl C (2010)
HSF1-controlled and age-associated chaperone capacity in neurons and muscle cells of C.elegans.
PLoS ONE 5(1): e8568.



Witan H, Gorlovoy P, Kaya AM, Koziollek-Drechsler I, Neumann H, Behl C, Clement AM (2009)
Wild-type Cu/Zn superoxide dismutase (SOD1) does not facilitate, but impedes the formation of protein aggregates of amyotrophic lateral sclerosis causing mutant SOD1.
Neurobiol. Disease 36, 331-342.

Clement AB, Gamerdinger M, Tamboli IY, Lütjohann D, Walter J, Greeve I, Gimpl G, Behl C (2009)
Adaptation of neuronal cells to chronic oxidative stress is associated with altered lipid homeostasis and lysosomal function.
J. Neurochem. 111, 669-82.

Kern A, Behl C (2009)
The unsolved relationship of brain aging and late-onset Alzheimer disease.
Biochim. Biophys. Acta 1790(10): 1124-1132.

Bondesson M, Jönsson J, Pongratz I, Olea N, Cravedi JP, Zalko D, Håkansson H, Halldin K, Di Lorenzo D, Behl C, Manthey D, Balaguer P, Demeneix B, Fini JB, Laudet V, Gustafsson JÅ (2009)
A CASCADE of effects of bisphenol A.
Reprod. Toxicol. 28(4): 563-567.

Hajieva P, Mocko JB, Moosmann B, Behl C (2009)
Novel imine antioxidants at low nanomolar concentrations protect dopaminergic cells from oxidative neurotoxicity.
J. Neurochem. 110(1): 118-132.

Hanstein R, Trotter J, Behl C, Clement AB (2009)
Increased connexin 43 expression as a potential mediator of the neuroprotective activity of the corticotropin-releasing hormone.
Mol. Endocrinol. 23(9): 1479-1493.

Gamerdinger M, Hajieva P, Kaya AM, Wolfrum U, Hartl FU, Behl C (2009)
Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3.

EMBO J 28(7): 889-901.

Hajieva P, Kuhlmann C, Luhmann HJ, Behl C (2009)
Impaired Calcium Homeostasis in Aged Hippocampal Neurons.
Neurosci. Lett. 451(2): 119-123.



Hanstein R, Lu A, Wurst W, Holsboer F, Deussing JM, Clement, AB, Behl C (2008)
Transgenic overexpression of corticotropin releasing hormone provides partial protection against neurodegeneration in an in vivo model of acute excitotoxic stress.
Neuroscience 156, 712-721.

Waldron E, Isbert S, Kern A, Jaeger S, Martin AM, Hébert SS, Behl C, Weggen S, De Strooper B, Pietrzik CU (2008)
Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription.
Exp. Cell Res. 314, 2419-2433.

Gamerdinger M, Clement AB, Behl C (2008)
Effects of sulindac sulfide on the membrane architecture and the activity of gamma-secretase.
Neuropharmacology 54(6): 998-1005.

Clement AB, Hanstein R, Schröder A, Nagel H, Endres, K, Fahrenholz F, Behl C (2008)
Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress.
Neuroscience 152(2): 459-468.

Witan H, Kern A, Koziollek-Drechsler I, Wade R, Behl C, Clement AM (2008)
Heterodimer formation of wild-type and amyotrophic lateral sclerosis-causing mutant Cu/Zn-superoxide dismutase induces toxicity independent of protein aggregation.
Hum. Mol. Genet. 17 (10): 1373-1385.

Moosmann B, Behl C (2008)
Mitochondrially encoded cysteine predicts animal lifespan.
Aging Cell 7(1): 32-46.



Ebinger M, Behl C, Rosenhagen M, Uhr M (2007)
P-Glycoprotein has negligible effects on estradiol and testosterone in mice.

Neurosci. Lett. 427, 6-9.

Gamerdinger M, Clement AB, Behl C (2007)
Cholesterol-like effects of selective cyclooxygenase inhibitors and fibrates on cellular membranes and amyloid-beta production.
Mol Pharmacol 72(1): 141-151.

Kuhlmann CRW, Tamaki R, Gamerdinger M, Lessmann V, Behl C, Kempski OS, Luhmann HJ (2007)
Inhibition of the myosin light chain kinase prevents hypoxia-induced blood brain barrier disruption.
J Neurochem 102(2): 501-507.



Behl C (2006)
The search for novel avenues for the therapy and prevention of Alzheimer’s disease.
Drug News Perspect 19, 5-12.

Gamerdinger M, Manthey D, Behl C (2006)
Oestrogen receptor subtype-specific repression of calpain expression and calpain enzymatic activity in neuronal cells – implications for neuroprotection against Ca2+-mediated excitotoxicity.
J Neurochem 97(1), 57-68.

Hajieva P, Behl C (2006)
Antioxidants as a potential therapy against age-related neurodegenerative diseases: amyloid beta toxicity and Alzheimer’s disease.
Curr Pharm Design 12(6), 699-704.

Manthey D, Behl C (2006)
From structural biochemistry to expression profiling: Neuroprotective activities of estrogen.
Neuroscience 138(3), 845-850.

Kern A, Roempp B, Prager K, Walter J, Behl C (2006)
Down-regulation of endogenous amyloid precursor protein processing due to cellular aging.
J Biol Chem 281(5), 2405-2413.



Zschocke J, Bayatti N, Clement AM, Witan H, Figiel M, Engele J, Behl C (2005)
Differential promotion of glutamate transporter expression and function by glucocorticoids in astrocytes from various brain regions.
J Biol Chem 280, 34924-34932.

Ludemann N, Clement A, Hans VH, Leschik J, Behl C, Brandt R (2005) O-glycosylation of the tail domain of neurofilament protein M in human neurons and in spinal cord tissue of a rat model of amyotrophic lateral sclerosis (ALS)
J Biol Chem 280, 31648-31658.

Bayatti N, Behl C (2005)
The neuroprotective actions of corticotropin releasing hormone.
Aging Res Rev 4, 258-270.

Goodenough S, Schleusner D, Pietrzik C, Skutella T, Behl C (2005)
Glycogen synthase kinase 3ß links neuroprotection by 17ß-estradiol to key Alzheimer processes.
Neuroscience 132, 581-589.

Pietrzik C, Behl C (2005)
Concepts for the treatment of Alzheimer’s disease: molecular mechanisms and clinical application.
Int J Exp Pathol 86, 173-185.

Behl C (2005)
Oxidative stress in Alzheimer’s disease: implications for prevention and therapy.
Subcellular Biochemistry 38, 65-78.

Zschocke J, Bayatti N, Behl C (2005)
Caveolin and GLT-1 gene expression is reciprocally regulated in primary astrocytes: association of GLT-1 with non-caveolar lipid rafts.
Glia 49, 275-287.

Bayatti N, Hermann H, Lutz B, Behl C (2005)
Corticotropin-releasing hormone-mediated induction of intracellular signaling pathways and brain-derived neurotrophic factor expression is inhibited by the activation of the endocannabinoid system.
Endocrinology 146, 1205-1213.



Moosmann B, Behl C (2004)
Selenoproteins, cholesterol-lowering drugs, and the consequences: Revisiting of the mevalonate pathway.
Trends Cardiovas Med 14, 273-281.

Zitzler J, Link D, Schäfer R, Liebetrau W, Kazinski M, Bonin-Debs A, Behl C, Buckel P, Brinkmann U (2004)
High-throughput functional genomics identifies genes that ameliorate toxicity due to oxidative stress in neuronal HT-22 cells: GFPT2 protects cells against peroxide.
Mol Cell Proteomics 3, 834-840.

Schäfer M, Goodenough S, Moosmann B, Behl C (2004)
Inhibition of glycogen synthase kinase 3ß is involved in the resistance to oxidative stress in neuronal HT22 cells.
Brain Res 1005, 84-89.

Moosmann B, Behl C (2004)
Selenoprotein synthesis and side-effects of statins
Lancet 363, 892-894.

van de Stolpe A, Slycke AJ, Reinders MO, Zomer AW, Goodenough S, Behl C, Seasholtz AF, van der Saag PT (2004)
Estrogen receptor (ER) -mediated transcriptional regulation of the human corticotropin-releasing hormone-binding protein promoter: differential effects of ERα and ERβ.
Mol Endocrinol 18, 2908-2923.

Goodenough S, Conrad S, Skutella T, Behl C (2004) Inactivation of glycogen synthase kinase-3β protects against kainic acid-induced neurotoxicity in vivo.
Brain Res 1026, 116-125.



Marsicano G, Goodenough S, Monory K, Hermann H, Eder M, Cannich A, Azad SC, Cascio MG, Gutierrez SO, van der Stelt M, López-Rodriguez ML, Casanova E, Schütz G, Zieglgänsberger W, Di Marzo V, Behl C*, Lutz B* (2003)
CB1 cannabinoid receptors and on-demand defense against excitotoxicity.
Science 302: 84-88 (*co-corresponding authors).

Bayatti N, Zschocke J, Behl C (2003)
Brain region-specific neuroprotective action and signaling of corticotropin-releasing hormone in primary neurons.
Endocrinology, 144: 4051-4060.

Goodenough S, Schäfer M, Behl C (2003)
Estrogen-induced cell signalling in a cellular model of Alzheimer's disease.
J Steroid Biochem 84: 301-305.

Zschocke J, Manthey D, Bayatti N, Behl C (2003)
Functional interaction of estrogen receptor alpha and caveolin isoforms in neuronal SK-N-MC cells.
J Steroid Biochem 84: 167-170.

C Behl (2003)
Molecular Aging Research.



Behl C (2002)
Estrogen can protect neurons: modes of action.
J Steroid Biochem 83: 195-197.

Behl C (2002)
Neuroprotective strategies in Alzheimer’s disease.
Adv Exp Med Biol, 513: 475-496.

Behl C (2002)
Sex hormones, neuroprotection and cognition.
Prog Brain Res 138:135-142.

Moosmann B, Behl C (2002)
Antioxidants as treatment for neurodegenerative disorders.
Expert Opin Inv Drug 11:1407-1435.

Zschocke J, Manthey D, Bayatti N, van der Burg B, Goodenough S, Behl C (2002)
Estrogen receptor alpha-mediated silencing of caveolin gene expression in neuronal cells.
J Biol Chem 277:38772-38780.

Behl C (2002)
Estrogen as a neuroprotective hormone.
Nat Rev Neurosci 3: 433-442.

Behl C, Moosmann B (2002)
Oxidative nerve cell death in Alzheimer’s disease and stroke: antioxidants as neuroprotective compounds.
Biol Chem 383: 521-536.

Behl C, Moosmann B (2002)
Antioxidant neuroprotection in Alzheimer’s disease as preventive and therapeutic approach.
Free Radical Bio Med 33: 182-191.

Moosmann B, Behl C (2002)
Secretory peptide hormones are biochemical antioxidants: structure-activity relationship.
Mol Pharmacol 61: 260-268.

Marsicano G, Moosmann B, Hermann H, Lutz B, Behl C (2002) Neuroprotective properties of cannabinoids against oxidative stress: role of the cannabinoid receptor CB1.
J Neurochem 80: 448-456.



Moosmann B, Skutella T, Beyer K, Behl C (2001)
Protective activity of aromatic amines and imines against oxidative nerve cell death.
Biol Chem 382: 1601-1612.

Behl C, Moosmann B (2001)
Nachr Chem 49: 332-336.

Yamamoto A, Behl C (2001)
Human Nck-associated protein1 and its binding protein affect the metabolism of beta-amyloid precursor protein with Swedish mutation.
Neurosci Lett 316: 50-54.

Jahn H, Kiefer F, Behl C, Wiedemann K (2001)
Activation of guanylatecyclase by natriuretic peptides in mouse pituitary AtT20 cells is influenced by phosphorylation of ANP.
Neurochem Res 26: 473-478.

Manthey D, Heck S, Engert S, Behl C (2001)
Estrogen induces a rapid release of non-amyloidogenic amyloid ß precursor protein (APP) via the mitogen-activated-protein- (MAP-) kinase pathway.
Eur J Biochem 267: 5687-5692.



Wolozin B, Behl C (2000)
Mechanisms of Neurodegenerative Disorders
Part 1: Protein Aggregates
Arch Neurol 57: 793-796.

Wolozin B, Behl C (2000)
Mechanisms of Neurodegenerative Disorders.
Part 2: Control of Cell Death
Arch Neurol 57: 801-804.

Goodenough S, Engert S, Behl C (2000)
Testosterone stimulates rapid secretory amyloid precursor protein release from rat hypothalamic cells via the activation of the mitogen-activated protein kinase pathway.
Neurosci Lett 296: 49-52.

Behl C (2000)
Apoptosis and Alzheimer‘s Disease.
J Neural Transm 107:1325-1344.

Braun S, Liebetrau W, Berning B, Behl C (2000)
Vulnerability of clonal hippocampal cells to oxidative stress is increased by dexamethasone and associated with suppression of NF-κB.
Neurosci Lett 295: 101-104.

Post A, Crochemore C, Uhr M, Holsboer F, Behl C (2000)
Differential induction of NF-κB activity and neural cell death by antidepressants in vitro.

Eur J Neurosci 12: 4331-4337.

Klostermann A, Lutz B, Gertler F, Behl C (2000)
The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the Enabled/Vasodilator-stimulated Phosphoprotein-like Protein (EVL) via a novel carboxyterminal Zyxin-like domain.
J Biol Chem 275: 39647-39653.

Moosmann B, Behl C (2000)
Dietary phenols: Antioxidants for the brain?
Nutr Neurosci (Invited Comment) 3: 1-10.

Greeve I, Hermans-Borgmeyer I, Fehr S, Brellinger C, Gomez-Isla T, Hyman BT, Behl C, Levkau B, Nitsch RM (2000)
Expression of seladin-1 -a novel neuroprotective gene with homology to oxido-reductases- is associated with selective vulnerability in Alzheimer’s disease.
J Neurosci 20: 7345-7352.

Moosmann B, Behl C (2000)
Cytoprotective antioxidant function of tyrosine and tryptophan residues in transmembrane proteins.
Eur J Biochem 267: 5687-5692.

Lezoualc’h F, Engert S, Berning B, Behl C (2000)
Corticotropin-releasing factor-mediated neuroprotection is associated with increased release of non-amyloidogenic amyloid ß protein precursor and with the suppression of NF-κB.
Mol Endocrinol 14: 147-159.



Heck S, Lezoualc’h F, Engert S, Behl C (1999)
Insulin-like growth factor-1-mediated neuroprotection against oxidative stress is associated with activation of Nuclear Factor κB
J Biol Chem. 274(14):9828-35