Univ.-Prof. Dr. rer. nat. Tobias Bopp

Univ.-Prof. Dr. rer. nat. Tobias Bopp

General Information

E-Mail
boppt@uni-mainz.de
Current position
Professor for Molecular Immunology, W3

Academic Education

2003-2006
  • Doctoral thesis at the Department of Immunology, University Medical Center, Mainz University
1997 - 2003
  • Biology (Diploma), Johannes Gutenberg University Mainz, Germany, E. Schmitt

Scientific Degrees

PhD thesis
  • Dr. rer. nat. ("magna cum laude"), Institute for Immunology, Johannes Gutenberg University Mainz, 2006, E. Schmitt

Professional Career

2019 - present

  • Professor (W3) and Chair, Institute of Immunology, University Medical Center, Johannes Gutenberg University Mainz

2012 - 2019

  • W2 Professor for Molecular Immunology, Institute of Immunology, Johannes Gutenberg University Mainz

2008 - 2011

  • Groupleader, Institute for Immunology, Johannes Gutenberg University Mainz, Prof. H. Schild

2006 - 2008

  • Postdoctoral Fellow, Institute for Immunology, Johannes Gutenberg University Mainz, Prof. E. Schmitt

Honours and Other Activities

Since 2024

  • Member, Review Board of the German Research Foundation (DFG) for the Subject Area Immunology

Since 2022

  • Principle Investigator, Cluster of Excellence Initiative Com2Life, together with Technical University of Darmstadt and Max Planck Institute for Polymer Research, Mainz, Germany

Since 2020

  • Elected faculty council member, University Medical Center (UMC), Johannes Gutenberg University (JGU) Mainz, Germany
  • Member, German Society for Immunology (DGfI) Advisory Board

Since 2019

  • Executive Committee, Resilience, Adaptation and Longevity (ReALity), Life Sciences Excellence Initiative JGU Mainz, Germany

Since 2018

  • Faculty Member DKTK (German Cancer Consortium)

Since 2017

  • Co-Spokesperson of the Collaborative Research Center (CRC) 1292 funded by the DFG
  • Member, Committee for science and research promotion, UMC, JGU Mainz
  • Member, Committee for habilitation and junior development, UMC, JGU Mainz
  • Director, Research Center for Immunotherapy (FZI), UMC, JGU Mainz, Germany
  • Spokesperson, University Cancer Center (UCT) Mainz section "Cancer Immunotherapy", JGU Mainz, Germany

Since 2016

  • Faculty member, German Immuneregulation Meeting
  • Invited member, European Academy for Tumor Immunology (EATI)
  • Advisory Board Member, UCT and Comprehensive Cancer Center (CCC) Mainz, JGU Mainz, Germany

Since 2013

  • Spokesman, Section "T cells: Subpopulations and Functions" within the DGfI
  • Representative of the members, "Mainz Research School of Translational Biomedicine" (TRANSMED), UMC, JGU Mainz, Germany 

2012

  • Member, PhD thesis committee, University of Oslo, Norway (2012 - present)
  • Invitation to the selection symposium Paul Ehrlich- und Ludwig Darmstaedter-Nachwuchspreis

2010

  • "Fritz und Ursula Melchers Award" of the DGfI
  • Administration of animal experiments (according to FELASA C)

2007 - 2009

  • Promotion by the Carl-Zeiss-Foundation

Organization of academic events: Annual meetings, DGfI section "T cells: Subpopulations and functions", Marburg, Germany (since 2013); 1st International Symposium " Immune Evasion in Malignant and Chronic Infectious Diseases", Deidesheim, Germany, Co-Organizer (2019); 8th Sino-German Symposium on Immunology of the DGfI and the Chinese Society for Immunology, Co-Organizer (2024).

Supervision of Researchers in Early Career Phases: Lectures and seminars in immunology, mentoring of 10 PhD and 5 Master candidates, TRANSMED Board member, IRTG CRC 1292, Supervisor in >20 Thesis Advisory Commitees (since 2020).

 

Selected Publications

  1. Klaus T, Wilson AS, Vicari E, Hadaschik E, Klein M, Helbich SS, Kamenjarin N, Hodapp K, Schunke J, Haist M, Butsch F, Probst HC, Enk AH, Mahnke K, Waisman A, Bednarczyk M, Bros M, Bopp T, Grabbe S. Impaired regulatory T cell-dendritic cell interactions contribute to autoimmunity in leukocyte adhesion deficiency type-1. JCI Insight. Nov 8:e162580, 2022 (DOI: 10.1172/jci.insight.162580). OA = Open Access →This work shows that CD18 is crucial for Treg-dendritic cell interactions to prevent autoimmunity

  2. K. Johann, T. Bohn, F. Shahneh, N. Luther, A. Birke, H. Jaurich, M. Helm, M. Klein, V. K. Raker, T. Bopp, M. Barz, C. Becker “Therapeutic Melanoma Inhibition by Local Micelle-Mediated Cyclic Nucleotide Repression”, Nat. Commun. 12, 5981, 2021 
(DOI: 10.1038/s41467-021-26269-w). OA → This work shows that AC inhibitor micelles repress tumor progression and improve the anti-tumor immune response

  3. L. Schaupp, S. Muth, L. Rogell, M. Kofoed-Branzk, F. Melchior, S. Lienenklaus, S. C. Ganal-Vonarburg, M. Klein, F. Guendel, T. Hain, K. Schütze, U. Grundmann, V. Schmitt, M. Dorsch, J. Spanier, P. K. Larsen, T. Schwanz, S. Jäckel, C. Reinhardt, T. Bopp, S. Danckwardt, K. Mahnke, G. A. Heinz, M. F. Mashreghi, P. Durek, U. Kalinke, O. Kretz, T. B. Huber, S. Weiss, C. Wilhelm, A. J. Macpherson, H. Schild, A. Diefenbach, H. C. Probst “Microbiota-Induced Type I Interferons Instruct a Poised Basal State of Dendritic Cells”, Cell 181, 5, 1080, 2020 (DOI: 10.1016/j.cell.2020.04.022). OA → Here the role of microbiota in peripheral immune response and tolerance was shown.

  4. T. Bohn, S. Rapp, N. Luther, M. Klein, T. J. Bruehl, N. Kojima, P. Aranda Lopez, J. Hahlbrock, S. Muth, S. Endo, S. Pektor, A. Brand, K. Renner, V. Popp, K. Gerlach, D. Vogel, C. Lueckel, D. Arnold-Schild, J. Pouyssegur, M. Kreutz, M. Huber, J. Koenig, B. Weigmann, H. C. Probst, E. von Stebut, C. Becker, H. Schild, E. Schmitt, T. Bopp “Tumor Immunoevasion via Acidosis-Dependent Induction of Regulatory Tumor-Associated Macrophages”, Nat. Immunol. 19, 1319, 2018 (DOI: 10.1038/s41590-018-0226-8). OA → The team around T. Bopp revealed that acidification in the tumor microenvironment suppresses effective anti-tumor immunity.

  5. A. Ulges, E. J. Witsch, G. Pramanik, M. Klein, K. Birkner, U. Buhler, B. Wasser, F. Luessi, N. Stergiou, S. Dietzen, T. J. Brühl, T. Bohn, G. Bündgen, H. Kunz, A. Waisman, H. Schild, E. Schmitt, F. Zipp, T. Bopp “Protein Kinase CK2 Governs the Molecular Decision between Encephalitogenic TH17 Cell and Treg Cell Development”, Proc. Natl. Acad. Sci. U.S.A. 113, 10145, 2016 (DOI: 10.1073/pnas.1523869113). OA → This publication shows that the protein kinase CK2 plays a pivotal role in TH17 an Treg polarization and function

  6. A.  Ulges, M. Klein, S. Reuter, B. Gerlitzki, M. Hoffmann, N. Grebe, V. Staudt, N. Stergiou, T. Bohn, T. J. Brühl, S. Muth, H. Yurugi, K. Rajalingam, I. Bellinghausen, A. Tuettenberg, S. Hahn, S. Reißig, I. Haben, F. Zipp, A. Waisman, H. C. Probst, A. Beilhack, T. Buchou, O. Filhol-Cochet, B. Boldyreff, M. Breloer, H. Jonuleit, H. Schild, E. Schmitt, T. Bopp “Protein Kinase CK2 Enables Regulatory T Cells to Suppress Excessive TH2 Responses in vivo”, Nat. Immunol. 16, 267, 2015 (DOI: 10.1038/ni.3083). OA → This work shows that CK2 in Tregs is required to control Th2 responses

  7. E. Schmitt, M. Klein, T. Bopp “Th9 Cells, New Players in Adaptive Immunity”, Trends Immunol. 35, 61, 2014 (DOI: 10.1016/j.it.2013.10.004). → This review summarizes the long time unappreciated Th9 helper subset which is also involved in tumor suppression

  8. M. Vaeth, T. Gogishvili, T. Bopp, M. Klein, F. Berberich-Siebelt, S. Gattenloehner, A. Avots, T. Sparwasser, N. Grebe, E. Schmitt, T. Hünig, E. Serfling, J. Bodor “Regulatory T Cells Facilitate the Nuclear Accumulation of Inducible cAMP Early Repressor (ICER) and Suppress Nuclear Factor of Activated T Cell c1 (NFATc1)”, Proc. Natl. Acad. Sci. U.S.A. 108, 2480, 2011 (DOI: 10.1073/pnas.1009463108). OA → This work indicates that natural Tregs suppress T-cell responses by the cAMP-dependent nuclear accumulation of ICER/CREM and inhibition of NFATc1 and IL-2 induction.

  9. V. Staudt, E. Bothur, M. Klein, K. Lingnau, S. Reuter, N. Grebe, B. Gerlitzki, M. Hoffmann, A. Ulges, C. Taube, N. Dehzad, M. Becker, M. Stassen, A. Steinborn, M. Lohoff, H. Schild, E. Schmitt, T. Bopp “Interferon-Regulatory Factor 4 is Essential for the Developmental Program of T helper 9 Cells”, Immunity 33, 192, 2010 (DOI: 10.1016/j.immuni. 2010.07.014). OA → This work reveals thar IRF4 has a central function in Th9 polarization and function

  10. T. Bopp, C. Becker, M. Klein, S. Klein-Hessling, A. Palmetshofer, E. Serfling, V. Heib, M. Becker, J. Kubach, S. Schmitt, S. Stoll, H. Schild, M. S. Staege, M. Stassen, H. Jonuleit, E. Schmitt “Cyclic Adenosine Monophosphate is a Key Component of Regulatory T Cell-Mediated Suppression”, J. Exp. Med. 204, 1303, 2007 (DOI: 10.1084/jem.20062129). OA → This work shows that Tregs inhibit effector T cells in a cell-contact- and cAMP-dependent manner.

Further publications can be found here.

 

 

Institut für Immunologie

Universitätsmedizin Mainz
Geb. 308A, 2./3.OG
Langenbeckstr. 1
55131 Mainz
Tel: +49 (0)6131-17 6198
Fax: +49 (0)6131-17 6202