English
Univ.-Prof. Dr. rer. nat. Tobias Bopp
General Information
- Current position
Professor for Molecular Immunology, W3
Academic Education
- 2003-2006
- Doctoral thesis at the Department of Immunology, University Medical Center, Mainz University
- 1997 - 2003
- Biology (Diploma), Johannes Gutenberg University Mainz, Germany, E. Schmitt
Scientific Degrees
- PhD thesis
- Dr. rer. nat. ("magna cum laude"), Institute for Immunology, Johannes Gutenberg University Mainz, 2006, E. Schmitt
Professional Career
- 2019 - present
- Director at the Institute for Immunology, University Medical Center, Johannes Gutenberg-University Mainz
- 2012 - 2018
- W2 Professor for Molecular Immunology, Institute for Immunology, Johannes Gutenberg University Mainz
- 2008 - 2011
- Groupleader, Institute for Immunology, Johannes Gutenberg University Mainz, Prof. H. Schild
- 2006 - 2008
- Postdoctoral Fellow, Institute for Immunology, Johannes Gutenberg University Mainz, Prof. E. Schmitt
Honours and Other Activities
- 2018
- DKTK (German Cancer Consortium) Faculty Member
- 2017
- Co-Speaker of the CRC SFB1292
- Member of the committee for science and research promotion of the University Medical Center Mainz
- Member of the committee for habilitation and junior development of the University Medical Center Mainz
- Speaker and coordinator of the "Forschungszentrum für Immuntherapie" (FZI) at the University Medical Center of the Johannes Gutenberg University Mainz
- Expert committee member Elite Network of Bavaria
- Speaker of the UCT/CCC section "Cancer Immunotherapy"
- 2016
- Member of the Steering Committee of the "Forschungszentrum für Immuntherapie" (FZI) at the University Medical Center of the Johannes Gutenberg University Mainz
- Member of the NOVARTIS Advisory Board for Immunology
- Faculty member of the German Immuneregulation Meeting
- Member of the advisory board of the Comprehensive Cancer Center Mainz
- 2014
- Member of the Teaching committee of the "Forschungszentrum für Immuntherapie" (FZI) at the University Medical Center of the Johannes Gutenberg University Mainz
- 2013
- Elected Spokesman of the Section "T cells: Subpopulations and Functions" within the German Society for Immunology (DGfI)
- Speaker of the Members of the "Mainz Research School of Translational Biomedicine" (TRANSMED)
- 2012
- Member of the PhD Thesis Evaluation committee at the University of Oslo, Norway
- Auswahlsymposium zum "Paul Ehrlich- und Ludwig Darmstaedter-Nachwuchspreis"
- 2010
- "Fritz und Ursula Melchers Award" of the DGfI
- Administration of animal experiments (according to FELASA C)
- 2008 - present
- Referee for international scientific journals (Cell, Nature Reviews Immunology, Nature Immunology, Immunity, EMBO, JEM, JCI, JACI, TII, Blood, etc.)
- 2008
- Founding member of the "Forschungszentrum für Immuntherapie" (FZI) at the University Medical Center of the Johannes Gutenberg University Mainz
- Boehringer Ingelheim Award
- 2007 - 2009
- Promotion by the Carl-Zeiss-Foundation
Selected Publications
- Bohn T, Rapp S, Luther N, Klein M, Bruehl TJ, Kojima N, Aranda Lopez P, Hahlbrock J, Muth S, Endo S, Pektor S, Brand A, Renner K, Popp V, Gerlach K, Vogel D, Lueckel C, Arnold-Schild D, Pouyssegur J, Kreutz M, Huber M, Koenig J, Weigmann B, Probst HC, von Stebut E, Becker C, Schild H, Schmitt E, and Bopp T. (2018) Tumor immunoevasion via acidosis dependent induction of regulatory tumor-associated macrophages. Nature Immunology in press.
- Ulges A*, Witsch EJ*, Pramanik G, Klein M, Birkner K, Bühler U, Wasser B, LuessiF, Stergiou N, Dietzen S, Brühl TJ, Bohn T, Bündgen G, Kunz H, Waisman A, Schild H, Schmitt E, Zipp F$, Bopp T$ (2016). Protein kinase CK2 governs the molecular decision between encephalitogenic TH17 cell and Treg cell development. Proc Natl Acad Sci U S A. 113: 10145-50.
- Paterka M, Siffrin V, Voss JO, Werr J, Hoppmann N, Gollan R, Belikan P, Bruttger J, Birkenstock J, Jung S, Esplugues E, Yogev N, Flavell RA, Bopp T, Zipp F. (2016) Gatekeeper role of brain antigen-presenting CD11c+ cells in neuroinflammation. EMBO J. 35(1):89-101.
- Ulges A, Klein M, Reuter S, Gerlitzki B, Hoffmann M, Grebe N, Staudt V, Stergiou N, Bohn T, Brühl T-J, Muth S, Yurugi H, Rajalingam K, Bellinghausen I, Tuettenberg A, Hahn S, Reißig S, Haben I, Zipp F, Waisman A, Probst HC, Beilhack A, Buchou T, Filhol-Cochet O, Boldyreff B, Breloer M, Jonuleit H, Schild H, Schmitt E, Bopp T (2015) Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo. Nat. Immunol. 16: 267–275
- Schmitt E, Klein M & Bopp T (2013) Th9 cells, new players in adaptive immunity. Trends Immunol. 48: 115–125
- Schmitt E, Bopp T. (2012) Amazing IL-9: revealing a new function for an "old" cytokine. J Clin Invest. 122(11):3857-9.
- Vaeth M*, Gogishvili T*, Bopp T*, Klein M, Berberich-Siebelt F, Gattenloehner S, Avots A, Sparwasser T, Grebe N, Schmitt E, Hünig T, Serfling E & Bodor J (2011) Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1). Proceedings of the National Academy of Sciences of the United States of America 108: 2480–2485.
- Staudt V, Bothur E, Klein M, Lingnau K, Reuter S, Grebe N, Gerlitzki B, Hoffmann M, Ulges A, Taube C, Dehzad N, Becker M, Stassen M, Steinborn A, Lohoff M, Schild H, Schmitt E & Bopp T (2010) Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells. Immunity 33: 192–202
- Bopp T, Becker C, Klein M, Klein-Hessling S, Palmetshofer A, Serfling E, Heib V, Becker M, Kubach J, Schmitt S, Stoll S, Schild H, Staege MS, Stassen M, Jonuleit H & Schmitt E (2007) Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. J. Exp. Med. 204: 1303–1310
- Bopp T, Palmetshofer A, Serfling E, Heib V, Schmitt S, Richter C, Klein M, Schild H, Schmitt E & Stassen M (2005) NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells. J. Exp. Med. 201: 181–187
* joint first authors, $ joint senior authors
