Univ.-Prof. Dr. rer. nat. Michael Delacher

Allgemeine Informationen

E-Mail

delacher@uni-mainz.de 

Derzeitige Position

Professor für Systembiologie chronischer Infektionen,

W2 (Tenure Track)

Akademische Ausbildung

2012-2016

Doctor rerum naturalium (Dr. rer. nat.) in Cancer Biology with the thesis "Transcriptional Control of Regulatory T cells", conducted at the German Cancer Research Center, Department of Tumor Immunology, Heidelberg, Germany, and the Weizmann Institute of Science, Department of Immunology, Rehovot, Israel, and awarded by Ruperto Carola University of Heidelberg, Heidelberg, Germany. Thesis Supervisor: Prof. Dr. med. Markus Feuerer and Prof. Jakub Abramson, PhD.

2010-2012

Master of Science (M.Sc.) in Molecular Medicine with the thesis "T-regulatory cells prevent T-helper cell induced Dendritic cell formation", performed with Stanford University, Department of Pathology, Stanford, CA, USA, and awarded by Ulm University Medical School, Ulm, Germany. Thesis Supervisor: Prof. Edgar G Engleman, MD.

2006-2012

Bachelor of Science (B.Sc.) in Pharmaceutical Biotechnology with the thesis "Evaluation of the Immune Response in Breast Cancer Patients following Treatment with MVA-BN®-HER2", performed with BN ImmunoTherapeutics Inc., Department of Human Immune Monitoring, Mountain View, CA, USA, and awarded by Biberach University, Biberach, Germany. Thesis Supervisor: Fatema Legrand, PhD.

Beruflicher Werdegang

2021 - present

W2 Professor (Tenure Track) for Systems Biology of Chronic Infections, Faculty of Medicine, University Medical Center of the Johannes-Gutenberg University (JGU) Mainz, Germany.2

2018 - 2021

Postdoctoral Scientist, Leibniz Center for Immunotherapy, Department of Immunology, Regensburg University Clinics, Regensburg, Germany.

2016 - 2017

Postdoctoral Scientist, German Cancer Research Center, Department of Immunology, Heidelberg, Germany.

2012 - 2016

Phd Student, German Cancer Research Center, Department of Immunology, Heidelberg, Germany and Weizmann Institute of Science, Department of Immunology, Rehovot, Israel.

2011 - 2012

Visiting Master's Student, Stanford University School of Medicine, Department of Pathology, Stanford, USA.

2009 - 2010

Visiting Bachelor's Student, BN ImmunoTherapeutics, Inc., Department of Human Immune Monitoring, Mountain View, USA.

Auszeichnungen und weitere Aktivitäten

2022

Hans-Jochem Kolb Research Award: Basic Science Award, awarded at "Graft versus host/Graft versus Leukaemia Meeting 2022", by the Department of Internal Medicine III, University Hospital Regensburg, Germany.

2021

Research Prize of the German Working Group for Hematopoietic Stem Cell Transplantation and Cellular Therapy, awarded at the HSCT meeting 2021, by the Department for Haematology, Oncology and Rheumatology, University Hospital Heidelberg, Germany.

2019

Competitive travel cost stipend by the German Society for Immunology for an oral presentation at the 17th International Congress of Immunology in Beijing, China.

2017

Competitive travel cost stipend by the German Society for Immunology for an oral presentation at the Midwinter Conference in Seefeld, Austria.

2015

Competitive travel cost stipend by the German Society for Immunology for an oral presentation at the 4th European Congress of Immunology in Vienna, Austria.

2011 - 2012

PROMOS fellowship for Master's Thesis with Stanford University, CA, USA.

2012 - 2016

Competitive PhD position funding by the German-Israeli Helmholtz Research School in Cancer Biology and the German Cancer Research Center.

Ausgewählte Publikationen

1. Delacher, M., Simon, M., Sanderink, L., Hotz-Wagenblatt, A., Wuttke, M., Schambeck, K., Schmidleithner, L., Bittner, S., Pant, A., Ritter, W., Hehlgans, T., Riegel, D., Schneider, V., Groeber-Becker, F., Eigenberger, A., Gebhardt, C., Strieder, N., Fischer, A., Rehli, M., Hoffmann, P., Edinger, M., Strowig, T., Huehn, J., Schmidl, C., Prantl, L., Werner, J., Brors, B., Imbusch, C.D., Feuerer, M: Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells. Immunity 2021: https://pubmed.ncbi.nlm.nih.gov/33789089/
2. Delacher, M., Barra, M. M., Herzig, Y., Eichelbaum, K., Mahmoud-Reza, R., Richards, DM., Träger, U., Hofer, AC., Kazakov, A., Braband, KL., Gonzalez, M., Wöhrl, L., Schambeck, K., Imbusch, C. D., Abramson, J., Krijgsveld, J., Feuerer, M: Quantitative proteomics identifies TCF1 as a negative regulator of Foxp3 expression in conventional T cells. iScience 2020: https://pubmed.ncbi.nlm.nih.gov/32422593/
3. Delacher, M., Imbusch, C. D., Hotz-Wagenblatt, A., Mallm, J. P., Bauer, K., Simon, M., Riegel, D., Rendeiro, A. F., Bittner, S., Sanderink, L., Pant, A., Schmidleithner, L., Braband, K. L., Echtenachter, B., Fischer, A., Giunchiglia, V., Hoffmann, P., Edinger, M., Bock, C., Rehli, M., Brors, B., Schmidl, C., Feuerer, M: Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF. Immunity 2020: https://pubmed.ncbi.nlm.nih.gov/31924477/
4. Delacher, M., Schmidl, C., Herzig, Y., Breloer, M., Hartmann, W., Brunk, F., Kagebein, D., Trager, U., Hofer, A. C., Bittner, S., Weichenhan, D., Imbusch, C. D., Hotz-Wagenblatt, A., Hielscher, T., Breiling, A., Federico, G., Grone, H. J., Schmid, R. M., Rehli, M., Abramson, J., Feuerer, M: Rbpj expression in regulatory T cells is critical for restraining TH2 responses. Nature Communication 2019: https://pubmed.ncbi.nlm.nih.gov/30962454/
5. Delacher, M., Imbusch, C. D., Weichenhan, D., Breiling, A., Hotz-Wagenblatt, A., Trager, U., Hofer, A. C., Kagebein, D., Wang, Q., Frauhammer, F., Mallm, J. P., Bauer, K., Herrmann, C., Lang, P. A., Brors, B., Plass, C., Feuerer, M: Genome-wide DNA-methylation landscape defines specialization of regulatory T cells in tissues. Nature Immunology 2017: https://pubmed.ncbi.nlm.nih.gov/28783152/