International Medical Services
Upcoming Events
Below you will find all upcoming events, such as talks, transferable skills courses, or lab courses.
All listed events carry a number of TransMed credit points corresponding to the time of attendance. 0.1 TransMed credit point is equivalent to 45 minutes of attendance.
FTN Seminar “Proteolytic processing of the prion protein at the neuronal plasma membrane and its role in the pathophysiology of dementia”
Veranstalter: FTN Focus Program Translational Neurosciences
| Datum | 25.11.2014 |
|---|---|
| Uhrzeit | 18:00-19:30 Uhr |
| Ort | UMC, Building 706, Lecture Hall, Langenbeckstr. 1 55131 Mainz
Contact: barbara.gordon-traeger@unimedizin-mainz.de |
| Zielgruppe | Scientists, Studentents and Physicians |
| Dozent | Prof Dr Markus Glatzel Abstract: The cellular prion protein (PrPC) is a glycosylphosphatidylinositol (GPI)-anchored protein with two variably occupied N-glycosylation sites, expressed mainly in neurons. Its pathological isoform (PrPSc) accumulates in prion diseases and represents an essential component of the transmissible entity, the “prion”. Besides its key role in prion-diseases, PrPC plays an important role in Alzheimer disease. Here it was recently identified as a receptor for oligomeric forms or beta-amyloid, the neurotoxic species responsible for initiation and progression of Alzheimer disease (AD). Recent data concerning proteolytic processing of PrPC at plasma membranes and it implications for pathophysiology of prion disease and AD will be presented. |
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