Host of this event is Prof. Dr. Heiko J. Luhmann, Institute of Physiology ( luhmann@uni-mainz.de)

Abstract: State-of-the-art

tissue clearing methods provide unprecedented, high-quality optical access to

very large biological specimens from individual organs to entire intact

animals. When combined with light-sheet microscopy and image informatics,

currently available tissue-clearing methods including a hydrophilic tissue

clearing method CUBIC, allows us to perform whole-brain and whole-body imaging

with sub-cellular resolution. In addition, delipidation of biological specimens

by tissue-clearing methods enables whole-organ staining with specific

antibodies, which can be applied even to human biology and pathology. When

combined with tissue clearing, these labelling methods allow us to

systematically extract structural and functional information of complex

mammalian organs. In this talk, I discuss how tissue-clearing and its related

technologies have been successfully integrated to create new biological

insights and provide a perspective for future opportunities in biology and

medicine.

Please see attached flyer for further information.