The recent years have revealed that T cell priming is not a single event. Instead, several T cell - Dendritic cell interactions in different microanatomical locations of the lymph node are required for the optimal development of cellular immunity. In my talk, I will review our current knowledge of these events that lay the ground for a functional memory response during the first days of activation. I will further show our work on the T cell intrinsic function of the AP-1 factor BATF3 and discuss how it could be utilized to optimize adoptive immunotherapy approaches. Finally, I will share our unpublished results on the function of dendritic cells in the context of checkpoint immunotherapy.

You can find further information about Prof. Dr. Kastenmüllers interesting research here.