Pharmakologie für gesundes Altern

PD Dr. Ning Xia beschäftigt sich aktuell mit folgenden Themen aus dem Bereich Pharmakologie für gesundes Altern:

  • Die Rolle der B-Lymphozyten bei steatotischen Lebererkrankungen
  • Die Rolle des perivaskulären Fettgewebes (PVAT) bei der Regulation der Gefäßfunktion (DFG-Projekt, TransMed-Projekt)
  • Die Rolle der B-Lymphozyten bei der Regulation der Gefäßfunktion (BIF-Projekt, BMBF-Projekt)
  • Die Auswirkungen von Einsamkeit und sozialer Isolation auf das Herz-Kreislauf-System
  • Vascular Ageing (Link)

Publikationen von PD Dr. Xia
 

Selected Papers:

The role of B lymphocytes in steatosis liver diseases

  • Li H, Xia N: The multifaceted roles of B lymphocytes in metabolic dysfunction-associated steatotic liver disease. Front Immunol 2024, 15:1447391. (link)  
  • Karl M, Hasselwander S, Zhou Y, Reifenberg G, Kim YO, Park KS, Ridder DA, Wang X, Seidel E, Hovelmeyer N, Straub BK, Li H#, Schuppan D#, Xia N#: Dual roles of B lymphocytes in mouse models of diet-induced nonalcoholic fatty liver disease. Hepatology 2022. (#indicates joint correspondence) (link)

The role of B lymphocytes in the regulation of vascular function

  • Hasselwander S#, Xia N#, Mimmler M, Ascher S, Knopp T, Reifenberg G, Karbach S, Ruf W, Reinhardt C, Li H: B lymphocyte-deficiency in mice promotes venous thrombosis. Heliyon 2022, 8:e11740.  (#indicates co-first author) (link) 
  • Xia N, Hasselwander S, Reifenberg G, Habermeier A, Closs EI, Mimmler M, Jung R, Karbach S, Lagrange J, Wenzel P, Daiber A, Munzel T, Hovelmeyer N, Waisman A, Li H: B Lymphocyte-Deficiency in Mice Causes Vascular Dysfunction by Inducing Neutrophilia. Biomedicines 2021, 9.(link)

The role of perivascular adipose tissue (PVAT) in the regulation of vascular function

  • Man AWC, Xia N#, Li H#: Vascular effects of perivascular adipose tissue-derived chemerin in obesity-associated cardiovascular disease. Cardiovasc Diabetol 2025, 24:249. (#indicates joint correspondence) (link)   
  • Man AWC, Zhou Y, Reifenberg G, Camp A, Munzel T, Daiber A, Xia N# and Li H#: Deletion of adipocyte NOS3 potentiates high-fat diet-induced hypertension and vascular remodeling via chemerin. Cardiovasc Res 2023,119: 2755-2769. (#indicates joint correspondence) ( Link )
  • Xia N, Reifenberg G, Schirra C, Li H: The Involvement of Sirtuin 1 Dysfunction in High-Fat Diet-Induced Vascular Dysfunction in Mice. Antioxidants (Basel) 2022, 11:541. (link) 
  • Zhou Y, Li H, Xia N: The Interplay Between Adipose Tissue and Vasculature: Role of Oxidative Stress in Obesity. Front Cardiovasc Med 2021, 8:650214.(link)  
  • Man AWC, Zhou Y, Xia N, Li H: Perivascular Adipose Tissue as a Target for Antioxidant Therapy for Cardiovascular Complications. Antioxidants (Basel) 2020, 9:574.(link)
  • Xia N, Weisenburger S, Koch E, Burkart M, Reifenberg G, Forstermann U, Li H: Restoration of perivascular adipose tissue function in diet-induced obese mice without changing bodyweight. Br J Pharmacol 2017, 174:3443-53. (link)
  • Xia N, Li H: The role of perivascular adipose tissue in obesity-induced vascular dysfunction. Br J Pharmacol 2017, 174:3425-42.(link)
  • Xia N, Forstermann U, Li H: Effects of resveratrol on eNOS in the endothelium and the perivascular adipose tissue. Ann N Y Acad Sci 2017, 1403:132-41. (link)
  • Xia N, Weisenburger S, Koch E, Burkart M, Reifenberg G, Forstermann U, Li H: Restoration of perivascular adipose tissue function in diet-induced obese mice without changing bodyweight. Br J Pharmacol 2017, 174:3443-53.(link)
  • Xia N, Horke S, Habermeier A, Closs EI, Reifenberg G, Gericke A, Mikhed Y, Munzel T, Daiber A, Forstermann U, Li H: Uncoupling of Endothelial Nitric Oxide Synthase in Perivascular Adipose Tissue of Diet-Induced Obese Mice. Arterioscler Thromb Vasc Biol 2016, 36:78-85. (link)

The effects of loneliness and social isolation on ageing-related diseases

  • Li H, Xia N: The role of oxidative stress in cardiovascular disease caused by social isolation and loneliness. Redox Biol 2020, 37:101585. (link)
  • Xia N, Li H: Loneliness, Social Isolation, and Cardiovascular Health. Antioxid Redox Signal 2018, 28:837-51. (link)
  • Siuda D, Wu Z, Chen Y, Guo L, Linke M, Zechner U, Xia N, Reifenberg G, Kleinert H, Forstermann U, Li H: Social isolation-induced epigenetic changes in midbrain of adult mice. J Physiol Pharmacol 2014, 65:247-55. (link)

The role of oxidative stress and nitric oxide (NO) in ageing related diseases

  • Li H, Forstermann U, Xia N, Kuntic M, Munzel T, Daiber A: Pharmacological targeting of endothelial nitric oxide synthase dysfunction and nitric oxide replacement therapy. Free Radic Biol Med 2025, 237:455-72. (link)
  • Man AWC, Steetskamp J, van der Ven J, Reifenberg G, Hasenburg A, Daiber A, Xia N, Li H: L-Citrulline Improves IGF-1 Signaling Pathway in Preeclampsia via Polyamines. Hypertension 2025. (link)
  • Shi X, Li P, Herb M, Liu H, Wang M, Wang X, Feng Y, van Beers T, Xia N, Li H, Prokosch V: Pathological high intraocular pressure induces glial cell reactive proliferation contributing to neuroinflammation of the blood-retinal barrier via the NOX2/ET-1 axis-controlled ERK1/2 pathway. J Neuroinflammation 2024, 21:105. (link)
  • Shi X, Li P, Herb M, Liu H, Wang M, Wang X, Feng Y, van Beers T, Xia N, Li H, Prokosch V: Pathological high intraocular pressure induces glial cell reactive proliferation contributing to neuroinflammation of the blood-retinal barrier via the NOX2/ET-1 axis-controlled ERK1/2 pathway. J Neuroinflammation 2024, 21:105. (link)
  • Jiang S, Xia N, Buonfiglio F, Bohm EW, Tang Q, Pfeiffer N, Olinger D, Li H, Gericke A: High-fat diet causes endothelial dysfunction in the mouse ophthalmic artery. Exp Eye Res 2024, 238:109727. (link)
  • Li H, Xia N: Alcohol and the vasculature: a love-hate relationship? Pflugers Arch 2023, 475:867-75. (link)
  • Jiang S, Xia N, Buonfiglio F, Bohm EW, Tang Q, Pfeiffer N, Olinger D, Li H, Gericke A: High-fat diet causes endothelial dysfunction in the mouse ophthalmic artery. Exp Eye Res 2023, 238:109727. (link)
  • Chronopoulos P, Manicam C, Zadeh JK, Laspas P, Unkrig JC, Gobel ML, Musayeva A, Pfeiffer N, Oelze M, Daiber A, Li H, Xia N, Gericke A: Effects of Resveratrol on Vascular Function in Retinal Ischemia-Reperfusion Injury. Antioxidants (Basel) 2023, 12. (link)
  • Wang M, Liu H, Xia N, Li H, van Beers T, Gericke A, Prokosch V: Intraocular Pressure-Induced Endothelial Dysfunction of Retinal Blood Vessels Is Persistent, but Does Not Trigger Retinal Ganglion Cell Loss. Antioxidants (Basel) 2022, 11. (link)
  • Xia N, Tenzer S, Lunov O, Karl M, Simmet T, Daiber A, Munzel T, Reifenberg G, Forstermann U, Li H: Regulation of NADPH Oxidase-Mediated Superoxide Production by Acetylation and Deacetylation. Front Physiol 2021, 12:693702. (link)
  • Musayeva A, Unkrig JC, Zhutdieva MB, Manicam C, Ruan Y, Laspas P, Chronopoulos P, Gobel ML, Pfeiffer N, Brochhausen C, Daiber A, Oelze M, Li H, Xia N, Gericke A: Betulinic Acid Protects from Ischemia-Reperfusion Injury in the Mouse Retina. Cells 2021, 10. (link)
  • Musayeva A, Jiang S, Ruan Y, Zadeh JK, Chronopoulos P, Pfeiffer N, Muller WEG, Ackermann M, Xia N, Li H, Gericke A: Aged Mice Devoid of the M3 Muscarinic Acetylcholine Receptor Develop Mild Dry Eye Disease. Int J Mol Sci 2021, 22. (link)
  • Marczynski P, Meineck M, Xia N, Li H, Kraus D, Roth W, Mockel T, Boedecker S, Schwarting A, Weinmann-Menke J: Vascular Inflammation and Dysfunction in Lupus-Prone Mice-IL-6 as Mediator of Disease Initiation. Int J Mol Sci 2021, 22. (link)
  • Man AWC, Zhou Y, Lam UDP, Reifenberg G, Werner A, Habermeier A, Closs EI, Daiber A, Munzel T, Xia N#, Li H#: l-Citrulline ameliorates pathophysiology in a rat model of superimposed preeclampsia. Br J Pharmacol 2021. (#indicates joint correspondence) (link)
  • Schirra C#, Xia N#, Schuffler A, Heck A, Hasselwander S, Forstermann U, Li H: Phosphorylation and activation of endothelial nitric oxide synthase by red fruit (Pandanus conoideus Lam) oil and its fractions. J Ethnopharmacol 2020, 251:112534. (#indicates co-first author)   (link)
  • Zadeh JK, Zhutdieva MB, Laspas P, Yuksel C, Musayeva A, Pfeiffer N, Brochhausen C, Oelze M, Daiber A, Xia N, Li H, Gericke A: Apolipoprotein E Deficiency Causes Endothelial Dysfunction in the Mouse Retina. Oxid Med Cell Longev 2019, 2019:5181429. (link)
  • Zadeh JK, Ruemmler R, Hartmann EK, Ziebart A, Ludwig M, Patzak A, Xia N, Li H, Pfeiffer N, Gericke A: Responses of retinal arterioles and ciliary arteries in pigs with acute respiratory distress syndrome (ARDS). Exp Eye Res 2019, 184:152-61. (link)
  • Li H, Xia N, Hasselwander S, Daiber A: Resveratrol and Vascular Function. Int J Mol Sci 2019, 20. (link)
  • Laspas P, Zhutdieva MB, Brochhausen C, Musayeva A, Zadeh JK, Pfeiffer N, Xia N, Li H, Wess J, Gericke A: The M1 muscarinic acetylcholine receptor subtype is important for retinal neuron survival in aging mice. Sci Rep 2019, 9:5222. (link)
  • Lang P, Hasselwander S, Li H#, Xia N#: Effects of different diets used in diet-induced obesity models on insulin resistance and vascular dysfunction in C57BL/6 mice. Sci Rep 2019, 9:19556. (#indicates joint correspondence)  (link)
  • Gericke A, Wolff I, Musayeva A, Zadeh JK, Manicam C, Pfeiffer N, Li H, Xia N: Retinal arteriole reactivity in mice lacking the endothelial nitric oxide synthase (eNOS) gene. Exp Eye Res 2019, 181:150-6. (link)
  • Gericke A, Mann C, Zadeh JK, Musayeva A, Wolff I, Wang M, Pfeiffer N, Daiber A, Li H, Xia N, Prokosch V: Elevated Intraocular Pressure Causes Abnormal Reactivity of Mouse Retinal Arterioles. Oxid Med Cell Longev 2019, 2019:9736047. (link)
  • Daiber A, Xia N, Steven S, Oelze M, Hanf A, Kroller-Schon S, Munzel T, Li H: New Therapeutic Implications of Endothelial Nitric Oxide Synthase (eNOS) Function/Dysfunction in Cardiovascular Disease. Int J Mol Sci 2019, 20. (link)
  • Ebert J, Wilgenbus P, Teiber JF, Jurk K, Schwierczek K, Dohrmann M, Xia N, Li H, Spiecker L, Ruf W, Horke S: Paraoxonase-2 regulates coagulation activation through endothelial tissue factor. Blood 2018, 131:2161-72. (link)
  • Xia N, Daiber A, Forstermann U, Li H: Antioxidant effects of resveratrol in the cardiovascular system. Br J Pharmacol 2017, 174:1633-46. (link)
  • Steven S, Oelze M, Hanf A, Kroller-Schon S, Kashani F, Roohani S, Welschof P, Kopp M, Godtel-Armbrust U, Xia N, Li H, Schulz E, Lackner KJ, Wojnowski L, Bottari SP, Wenzel P, Mayoux E, Munzel T, Daiber A: The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats. Redox Biol 2017, 13:370-85. (link)
  • Riebel M, Sabel A, Claus H, Xia N, Li H, Konig H, Decker H, Fronk P: Antioxidant capacity of phenolic compounds on human cell lines as affected by grape-tyrosinase and Botrytis-laccase oxidation. Food Chem 2017, 229:779-89. (link)
  • Munzel T, Daiber A, Steven S, Tran LP, Ullmann E, Kossmann S, Schmidt FP, Oelze M, Xia N, Li H, Pinto A, Wild P, Pies K, Schmidt ER, Rapp S, Kroller-Schon S: Effects of noise on vascular function, oxidative stress, and inflammation: mechanistic insight from studies in mice. Eur Heart J 2017, 38:2838-49. (link)
  • Kossmann S, Lagrange J, Jackel S, Jurk K, Ehlken M, Schonfelder T, Weihert Y, Knorr M, Brandt M, Xia N, Li H, Daiber A, Oelze M, Reinhardt C, Lackner K, Gruber A, Monia B, Karbach SH, Walter U, Ruggeri ZM, Renne T, Ruf W, Munzel T, Wenzel P: Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension. Sci Transl Med 2017, 9. (link)
  • Forstermann U, Xia N, Li H: Roles of Vascular Oxidative Stress and Nitric Oxide in the Pathogenesis of Atherosclerosis. Circ Res 2017, 120:713-35. (link)
  • Hohmann N, Xia N, Steinkamp-Fenske K, Forstermann U, Li H: Estrogen Receptor Signaling and the PI3K/Akt Pathway Are Involved in Betulinic Acid-Induced eNOS Activation. Molecules 2016, 21. (link)
  • Wu Z, Siuda D, Xia N, Reifenberg G, Daiber A, Munzel T, Forstermann U, Li H: Maternal treatment of spontaneously hypertensive rats with pentaerythritol tetranitrate reduces blood pressure in female offspring. Hypertension 2015, 65:232-7. (link)
  • Tobias S, Habermeier A, Siuda D, Reifenberg G, Xia N, Closs EI, Forstermann U, Li H: Dexamethasone, tetrahydrobiopterin and uncoupling of endothelial nitric oxide synthase. J Geriatr Cardiol 2015, 12:528-39. (link)
  • Riebel M, Sabel A, Claus H, Fronk P, Xia N, Li H, Konig H, Decker H: Influence of Laccase and Tyrosinase on the Antioxidant Capacity of Selected Phenolic Compounds on Human Cell Lines. Molecules 2015, 20:17194-207. (link)
  • Xia N, Forstermann U, Li H: Resveratrol as a gene regulator in the vasculature. Curr Pharm Biotechnol 2014, 15:401-8. (link)
  • Xia N, Strand S, Schlufter F, Siuda D, Reifenberg G, Kleinert H, Forstermann U, Li H: Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol. Nitric Oxide 2013, 32:29-35. (link)
  • Li H, Xia N, Forstermann U: Cardiovascular effects and molecular targets of resveratrol. Nitric Oxide 2012, 26:102-10. (link)
  • Yang Q, Xue HM, Wong WT, Tian XY, Huang Y, Tsui SK, Ng PK, Wohlfart P, Li H, Xia N, Tobias S, Underwood MJ, He GW: AVE3085, an enhancer of endothelial nitric oxide synthase, restores endothelial function and reduces blood pressure in spontaneously hypertensive rats. Br J Pharmacol 2011, 163:1078-85. (link)
  • Fusser M, Nesse GJ, Khobta A, Xia N, Li H, Klungland A, Epe B: Spontaneous mutagenesis in Csb(m/m)Ogg1(-)(/)(-) mice is attenuated by dietary resveratrol. Carcinogenesis 2011, 32:80-5. (link)
  • Xia N, Daiber A, Habermeier A, Closs EI, Thum T, Spanier G, Lu Q, Oelze M, Torzewski M, Lackner KJ, Munzel T, Forstermann U, Li H: Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein E knockout mice. J Pharmacol Exp Ther 2010, 335:149-54. (link)
  • Li H, Hortmann M, Daiber A, Oelze M, Ostad MA, Schwarz PM, Xu H, Xia N, Kleschyov AL, Mang C, Warnholtz A, Munzel T, Forstermann U: Cyclooxygenase 2-selective and nonselective nonsteroidal anti-inflammatory drugs induce oxidative stress by up-regulating vascular NADPH oxidases. J Pharmacol Exp Ther 2008, 326:745-53. (link)
  • Michaelis UR, Xia N, Barbosa-Sicard E, Falck JR, Fleming I: Role of cytochrome P450 2C epoxygenases in hypoxia-induced cell migration and angiogenesis in retinal endothelial cells. Invest Ophthalmol Vis Sci 2008, 49:1242-7. (link)
  • Jung O, Marklund SL, Xia N, Busse R, Brandes RP: Inactivation of extracellular superoxide dismutase contributes to the development of high-volume hypertension. Arterioscler Thromb Vasc Biol 2007, 27:470-7. (link)
  • Li H, Burkhardt C, Heinrich UR, Brausch I, Xia N, Forstermann U: Histamine upregulates gene expression of endothelial nitric oxide synthase in human vascular endothelial cells. Circulation 2003, 107:2348-54. (link)
  • Schwenn O, Xia N, Krummenauer F, Dick HB: [Prevention of early postoperative increase in intraocular pressure after phacoemulsification. Comparison of different antiglaucoma drugs]. Ophthalmologe 2001, 98:934-43. (link)