Publikationen: AG Rumpel

Originalarbeiten

Becker R, Choudhury P, Oti M, Fouani Y, Strobel B, Ketterer S, Rumpel S, Park J, Kreuz S, Maier U, Michelfelder S, Schön C (2026) STARR-CRAAVT: A platform to identify cell type-specific regulatory elements for next-generation gene therapy. iScience 29:1115469 doi: 10.1016/j.isci.2026.115469

Eppler J-B, Lai T, Aschauer DF, Rumpel S, Kaschube M (2026) Representational drift reflects ongoing balancing of stochastic changes by Hebbian learning. Proc. Natl. Acad. Sci. U.S.A. 123 (5) e2503046123. doi: 10.1073/pnas.2503046123

Elbaum-Mendelson L, Yuan W, Seiler JP-H, Blom N, Chan YC, Baig AH, Brose N, Rumpel S, & Ziv NE (2025) Revealing acute consequences of rapid degradation of synaptic fusion proteins at individual synapses using Auxin-Inducible Degron 2 technology. Commun Biol 8, 1589. doi: 10.1038/s42003-025-08996-8

Osuna-Vargas P, Kamacıoğlu A, Aschauer DF, Vlachos PE, Alipek S, Triesch, J, Rumpel S, & Kaschube M (2025) SynapFlow: A Modular Framework Towards Large-Scale Analysis of Dendritic Spines. In Proceedings of the IEEE/CVF International Conference on Computer Vision (pp. 5801-5811). doi: 10.48550/arXiv.2509.18926

Noda T, Kienle E, Eppler J-B, Aschauer DF, Kaschube M, Loewenstein Y, Rumpel S (2025) Homeostasis of a representational map in the neocortex. Nat. Neurosci. 28, 1533–1545. doi: 10.1038/s41593-025-01982-7 (discussed in: Ziv, Y (2025) Resilient cortical maps. Nat. Neurosci. 28, 1368–1369 (2025). doi: 10.1038/s41593-025-01957-8)

Seiler JP-H, Elpelt J, Ghobadi A, Kaschube M & Rumpel S (2025) Perceptual and semantic maps in individual humans share structural features that predict creative abilities. Commun Psychol 3, 30. doi: 10.1038/s44271-025-00214-9

Seiler JP-H, Elpelt J, Mashkov V, Ghobadi A, Kapoor A, Turner D, Kaschube M, Tuescher O & Rumpel S (2025) A reduced perception of sensory information is linked with elevated boredom in people with and without attention-deficit hyperactivity disorder. Commun Psychol 3, 47 (2025). doi: 10.1038/s44271-025-00233-6

Krummeich J, Nardi L, Caliendo C, Aschauer D, Engelhardt V, Arlt A, Maier J, Bicker F, Kwiatkowski MD, Rolski K, Vincze K, Schneider R, Rumpel S, Gerber S, Schmeisser MJ, Schweiger S (2024) Premature cognitive decline in a mouse model of tuberous sclerosis. Aging Cell 23, e14318. doi: 10.1111/acel.14318

Zerr K, Seiler JP-H, Rumpel S & Tüscher O (2024) Validation of a German version of the Boredom Proneness Scale and the Multidimensional State Boredom Scale. Sci Rep 14, 2905. doi: 10.1038/s41598-024-53236-4

Seiler JP-H & Rumpel S (2023) Modeling fashion as an emergent collective behavior of bored individuals. Sci Rep 13, 20480. doi: 10.1038/s41598-023-47749-7

Seiler JP-H, Zerr K, Rumpel S & Tüscher O (2023) High state boredom vastly affects psychiatric inpatients and predicts their treatment duration. Transl Psychiatry 13, 350. doi: 10.1038/s41398-023-02650-9

Vogel FW, Alipek S, Eppler J-B, Osuna-Vargas P, Triesch J, Bissen D, Acker-Palmer A, Rumpel S & Kaschube M (2023) Utilizing 2D-region-based CNNs for automatic dendritic spine detection in 3D live cell imaging. Sci Rep 13, 20497. doi: 10.1038/s41598-023-47070-3

Chan Y-C, Kienle E, Oti M, Di Liddo A, Mendez-Lago M, Aschauer DF, Peter M, Pagani M, Arnold C, Vonderheit A, Schön C, Kreuz S, Stark A, Rumpel S (2023) An unbiased AAV-STARR-Seq screen revealing the enhancer activity map of genomic regions in the mouse brain in vivo. Sci Rep 13, 6745. doi: 10.1038/s41598-023-33448-w

Chambers AR, Aschauer DF, Eppler J-B, Kaschube M, Rumpel S (2022) A stable sensory map emerges from a dynamic equilibrium of neurons with unstable tuning properties. Cereb Cortex 25;33(9):5597-5612 doi: 10.1093/cercor/bhac445

Seiler JPH, Dan O, Tüscher O, Loewenstein Y, Rumpel S (2022) Experienced entropy drives choice behavior in a boring decision-making task. Sci Rep 12, 3162. doi: 10.1038/s41598-022-06861-w

Aschauer DF, Eppler JB, Ewig L, Chambers AR, Pokorny C, Kaschube M, Rumpel S (2022) Learning-induced biases in the ongoing dynamics of sensory representations predict stimulus generalization. Cell Reports 38(6):110340. doi: 10.1016/j.celrep.2022.110340

Peter M, Aschauer DF, Rose R, Sinning A, Grössl F, Kargl D, Kraitsy K, Burkard TR, Luhmann HJ, Haubensak W, Rumpel S (2021) Rapid nucleus-scale reorganization of chromatin in neurons enables transcriptional adaptation for memory consolidation. PLoS ONE 16(5) e0244038. doi: 10.1371/journal.pone.0244038

Ceballo S, Bourg J, Kempf A, Piwkowska Z, Daret A, Pinson P, Deneux T, Rumpel S & Bathellier B (2019) Cortical recruitment determines learning dynamics and strategy. Nat. Commun 10:1479. doi: 10.1038/s41467-019-09450-0

Mongillo G, Rumpel S, Loewenstein Y (2018) Inhibitory connectivity defines the realm of excitatory plasticity. Nat Neurosci 22, 2117. doi: 10.1038/s41593-019-0546-5

Loewenstein Y, Yanover U, Rumpel S (2015) Predicting the dynamics of network connectivity in the neocortex. JNeurosci 35(36): 12535-12544. doi: 10.1523/jneurosci.2917-14.2015

Moczulska KE, Pichler P, Schutzbier M, Schleiffer A, Rumpel S, Mechtler K (2014) Deep and precise quantification of the mouse synaptosomal proteome reveals substantial remodeling during postnatal maturation. J Proteome Res. 13(10):4310-24. doi: 10.1021/pr500456t

Bathellier B, Tee SP, Hrovat C, Rumpel S (2013) A multiplicative reinforcement learning model capturing learning dynamics and inter-individual variability in mice. Proc Natl Acad Sci USA 110(49):19950-5. doi: 10.1073/pnas.1312125110

Moczulska KE, Tinter-Thiede J, Peter M, Ushakova L, Wernle T, Bathellier B, Rumpel S (2013) Dynamics of dendritic spines in the mouse auditory cortex during memory formation and memory recall. Proc Natl Acad Sci USA 110(45):18315-20. doi: 10.1073/pnas.1312508110

Aschauer DF, Kreuz S, Rumpel S (2013) Analysis of Transduction Efficiency, Tropism and Axonal Transport of AAV Serotypes 1, 2, 5, 6, 8 and 9 in the Mouse Brain. PLoS One 8(9):e76310. doi: 10.1371/journal.pone.0076310

Fischer RM, Fontinha BM, Kirchmaier S, Steger J, Bloch S, Panda S, Rumpel S, Tessmar-Raible K (2013) Co-expression of VAL- and TMT-opsins uncovers ancient photosensory interneurons and motorneurons in the vertebrate brain. PloS Biol. 11(6):e1001585. doi: 10.1371/journal.pbio.1001585

Peter M, Bathellier B, Fontinha B, Pliota P, Haubensak W, Rumpel S (2013) Transgenic mouse models enabling photolabeling of individual neurons in vivo. PLoS ONE 8(4):e62132. doi: 10.1371/journal.pone.0062132

Bathellier B, Ushakova L, Rumpel S (2012) Discrete neocortical dynamics predict behavioral categorization of sounds. Neuron 76(2):435-49. doi: 10.1016/j.neuron.2012.07.008 (discussed in: Harris KD (2012) Cell assemblies of the superficial cortex. Neuron 76(2):263–265. doi: 10.1016/j.neuron.2012.10.007)

Peter M, Scheuch H, Burkard TR, Tinter J, Wernle T, Rumpel S (2012) Induction of immediate early genes in the mouse auditory cortex after auditory cued fear conditioning to complex sounds. Genes Brain Behav. 11(3):314-24. doi: 10.1111/j.1601-183x.2011.00761.x

Loewenstein Y, Kuras A, Rumpel S (2011) Multiplicative dynamics underlies the emergence of the log-normal distribution of spine sizes in the neocortex in vivo. J Neurosci. 31 (26) 9481-9488. doi: 10.1523/JNEUROSCI.6130-10.2011

Ehrlich I, Klein M, Rumpel S, Malinow R (2007) PSD-95 is required for activity-driven synapse stabilization. Proc Natl Acad Sci USA 104(10):4176-81. doi: 10.1073/pnas.0609307104

Rumpel S, LeDoux J, Zador A, Malinow R (2005) Postsynaptic receptor trafficking underlying amygdala associative learning. Science 308(5718):83-8. doi: 10.1126/science.1103944 (discussed in: Maren S (2005) Synaptic mechanisms of associative memory in the amygdala. Neuron 47(6):783-6. doi: 10.1016/j.neuron.2005.08.009; Ehninger D, Matynia A, Silva AJ (2005) Trafficking in emotions. Nat Neurosci., 8(5):548-50. doi: 10.1038/nn0505-548)

Rumpel S, Kattenstroth G, Gottmann K (2004) Silent synapses in the immature visual cortex: layer-specific developmental regulation. J Neurophysiol. 91(2):1097-101. doi: 10.1152/jn.00443.2003

Plitzko D, Rumpel S, Gottmann K. (2001) Insulin promotes functional induction of silent synapses in differentiating neocortical neurons. Eur J Neurosci. 14(8):1412-5. doi: 10.1046/j.0953-816x.2001.01740.x

Rumpel S, Hoffmann H, Hatt H, Gottmann K, Mittmann T, Eysel UT (2000) Lesion-induced changes in NMDA receptor subunit mRNA expression in rat visual cortex. Neuroreport 11(18):4021-5. doi: 10.1097/00001756-200012180-00024

Rumpel S, Hatt H, Gottmann K (1998) Silent synapses in the developing rat visual cortex: evidence for postsynaptic expression of synaptic plasticity. J Neurosci. 18 (21) 8863-8874. doi: 10.1523/JNEUROSCI.18-21-08863.1998

Andere Publikationen

Seiler, JP-H, Eppler J-B, Dan O, Elpelt J, Kaschube M, & Rumpel S (2026) Towards Circuit Mechanisms of the Creative Process. Creativity Research Journal, 1–20. doi: 10.1080/10400419.2026.2646676

Eppler J-B, Kaschube M, Rumpel S (2025) Statistical learning and representational drift: A dynamic substrate for memories. Curr. Opin. Neurobiol. 94:103107 doi: 10.1016/j.conb.2025.103107

Seiler JP-H and Dan O (2024) Boredom and curiosity: the hunger and the appetite for information. Front Psychol. 15:1514348. doi: 10.3389/fpsyg.2024.1514348

Noda T, Aschauer DF, Chambers AR, Seiler JP-H, Rumpel S (2024) Representational maps in the brain: concepts, approaches, and applications. Front. Cell. Neurosci. 18: 1366200. doi: 10.3389/fncel.2024.1366200

Rumpel S (2018) Supporting recovery from brain injury. Science 360(6384):30-31. doi: 10.1126/science.aat2450

Aschauer D, Rumpel S (2018) The sensory neocortex and associative memory. Curr Top Behav Neurosci. 37:177-211. doi: 10.1007/7854_2016_453

Chambers AR, Rumpel S (2017) A stable brain from unstable components: Emerging concepts and implications for neural computation. Neuroscience 357:172-184. doi: 10.1016/j.neuroscience.2017.06.005

Mongillo G, Rumpel S, Loewenstein Y (2017) Intrinsic volatility of synaptic connections — a challenge to the synaptic trace theory of memory. Curr Opin Neurobiol. 46:7–13. doi: 10.1016/j.conb.2017.06.006

Rumpel S, Triesch J (2016) The dynamic connectome. e-Neuroforum 22(3), 48-53. doi: 10.1515/s13295-016-0026-2

Aschauer DF, Rumpel S (2014) Measuring the Functional Organization of the Neocortex at Large and Small Scales. Neuron 83(4), 756-758. doi: 10.1016/j.neuron.2014.08.008

Preprints

Osuna-Vargas P, Kamacioglu A, Aschauer DF, Vlachos PE, Alipek S, Triesch J, Rumpel S, Kaschube M (2025, Sep 23) SynapFlow: A Modular Framework Towards Large-Scale Analysis of Dendritic Spines. arXiv doi: arXiv:2509.18926v1

Becker R, Choudhury P, Oti M, Fouani Y, Strobel B, Ketterer S, Rumpel S, Park J, Kreuz S, Maier U, Michelfelder S, Schön C (2025, June 7) STARR-CRAAVT: A platform to design cell type-specific regulatory elements for next-generation gene therapy. bioRxiv doi: 2025.06.04.657008

Seiler JPH, Eppler J, Dan O, Elpelt J, Kaschube M, & Rumpel S (2025, April 14) Towards circuit mechanisms of the creative process: Describing the functions, mechanisms and neural correlates of creativity. PsyArXiv: 10.31234

Eppler JB, Lai T, Aschauer D, Rumpel S, Kaschube M (2025) Representational drift reflects ongoing balancing of stochastic changes by Hebbian learning. bioRxiv doi: 2025.01.05.631363

Elbaum L, Yuan W, Seiler JPH, Blom N, Chan Y, Baig AH, Brose N, Rumpel S, Ziv NE (2024) Revealing Acute Consequences of Rapid Protein Elimination at Individual Synapses using Auxin-Inducible Degron 2 Technology. bioRxiv doi: 2024.10.20.619267

Noda T, Kienle E, Eppler JB, Aschauer DF, Kaschube M, Loewenstein Y, Rumpel S (2023) Homeostasis of a representational map in the neocortex. bioRxiv doi: 2023.06.13.544358

Vogel FW, Alipek S, Eppler JB, Triesch J, Bissen D, Acker-Palmer A, Rumpel S, Kaschube M (2023) Fully automated detection of dendritic spines in 3D live cell imaging data using deep convolutional neural networks. bioRxiv doi:2023.01.08.522220

Aschauer DF, Eppler JB, Ewig L, Chambers A, Pokorny C, Kaschube M, Rumpel S (2019) A Basis Set of Elementary Operations Captures Recombination of Neocortical Cell Assemblies During Basal Conditions and Learning. ssrn ID=3438457