Visual Universitätsmedizin Mainz

Originalartikel

1: Farrell G, Schattenberg JM, Leclercq I, Yeh MM, Goldin R, Teoh N, Schuppan D.
Mouse Models of Nonalcoholic Steatohepatitis: Toward Optimization of Their
Relevance to Human Nonalcoholic Steatohepatitis. Hepatology. 2019
May;69(5):2241-2257. doi: 10.1002/hep.30333. Review. PubMed PMID: 30372785.


2: Dieterich W, Schuppan D, Schink M, Schwappacher R, Wirtz S, Agaimy A, Neurath
MF, Zopf Y. Influence of low FODMAP and gluten-free diets on disease activity and
intestinal microbiota in patients with non-celiac gluten sensitivity. Clin Nutr.
2019 Apr;38(2):697-707. doi: 10.1016/j.clnu.2018.03.017. Epub 2018 Apr 4. PubMed
PMID: 29653862.


3: Terryberry J, Tuomi J, Perampalam S, Peloquin R, Brouwer E, Schuppan D,
Guandalini S. Diagnostic accuracy of a fully automated multiplex celiac disease
antibody panel for serum and plasma. Clin Chem Lab Med. 2019 Mar 23. pii:
/j/cclm.ahead-of-print/cclm-2019-0088/cclm-2019-0088.xml. doi:
10.1515/cclm-2019-0088. [Epub ahead of print] PubMed PMID: 30903755.


4: Elli L, Ferretti F, Orlando S, Vecchi M, Monguzzi E, Roncoroni L, Schuppan D.
Management of celiac disease in daily clinical practice. Eur J Intern Med. 2019
Mar;61:15-24. doi: 10.1016/j.ejim.2018.11.012. Epub 2018 Dec 5. Review. PubMed
PMID: 30528262.


5: Zimmermann A, Darstein F, Hoppe-Lotichius M, Toenges G, Lautem A, Abel F,
Schad A, Mittler J, Vollmar J, Grimm D, Lang H, Galle PR, Zimmermann T, Schuppan
D. Cirrhosis risk score of the donor organ predicts early fibrosis progression
after liver transplantation. J Gastrointestin Liver Dis. 2019 Mar;28(1):53-61.
doi: 10.15403/jgld.2014.1121.281.crr. PubMed PMID: 30851173.


6: Kazankov K, Jørgensen SMD, Thomsen KL, Møller HJ, Vilstrup H, George J,
Schuppan D, Grønbæk H. The role of macrophages in nonalcoholic fatty liver
disease and nonalcoholic steatohepatitis. Nat Rev Gastroenterol Hepatol. 2019
Mar;16(3):145-159. doi: 10.1038/s41575-018-0082-x. Review. PubMed PMID: 30482910.


7: van Dijk F, Teekamp N, Post E, Schuppan D, Kim YO, Zuidema J, Steendam R,
Klose MHM, Meier-Menches SM, Casini A, Horvatovich PL, Sijbrandi NJ, Frijlink HW,
Hinrichs WLJ, Poelstra K, Beljaars L, Olinga P. The antifibrotic potential of a
sustained release formulation of a PDGFβ-receptor targeted rho kinase inhibitor.
J Control Release. 2019 Feb 28;296:250-257. doi: 10.1016/j.jconrel.2018.12.039.
Epub 2019 Jan 22. PubMed PMID: 30682444.


8: Caminero A, McCarville JL, Zevallos VF, Pigrau M, Yu XB, Jury J, Galipeau HJ,
Clarizio AV, Casqueiro J, Murray JA, Collins SM, Alaedini A, Bercik P, Schuppan
D, Verdu EF. Lactobacilli Degrade Wheat Amylase Trypsin Inhibitors to Reduce
Intestinal Dysfunction Induced by Immunogenic Wheat Proteins. Gastroenterology.
2019 Feb 22. pii: S0016-5085(19)30437-8. doi: 10.1053/j.gastro.2019.02.028. [Epub
ahead of print] PubMed PMID: 30802444.


9: Pfanzagl B, Zevallos VF, Schuppan D, Pfragner R, Jensen-Jarolim E. Histamine
causes influx via T-type voltage-gated calcium channels in an enterochromaffin
tumor cell line: potential therapeutic target in adverse food reactions. Am J
Physiol Gastrointest Liver Physiol. 2019 Feb 1;316(2):G291-G303. doi:
10.1152/ajpgi.00261.2018. Epub 2018 Dec 12. PubMed PMID: 30540489.


10: Ziegler K, Neumann J, Liu F, Fröhlich-Nowoisky J, Cremer C, Saloga J,
Reinmuth-Selzle K, Pöschl U, Schuppan D, Bellinghausen I, Lucas K. Nitration of
Wheat Amylase Trypsin Inhibitors Increases Their Innate and Adaptive
Immunostimulatory Potential in vitro. Front Immunol. 2019 Jan 21;9:3174. doi:
10.3389/fimmu.2018.03174. eCollection 2018. PubMed PMID: 30740114; PubMed Central
PMCID: PMC6357940.


11: Karsdal MA, Hjuler ST, Luo Y, Rasmussen DGK, Nielsen MJ, Holm Nielsen S,
Leeming DJ, Goodman Z, Arch RH, Patel K, Schuppan D. Assessment of liver fibrosis
progression and regression by a serological collagen turnover profile. Am J
Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G25-G31. doi:
10.1152/ajpgi.00158.2018. Epub 2018 Aug 30. PubMed PMID: 30160980.


12: Bellinghausen I, Weigmann B, Zevallos V, Maxeiner J, Reißig S, Waisman A,
Schuppan D, Saloga J. Wheat amylase-trypsin inhibitors exacerbate intestinal and
airway allergic immune responses in humanized mice. J Allergy Clin Immunol. 2019
Jan;143(1):201-212.e4. doi: 10.1016/j.jaci.2018.02.041. Epub 2018 Mar 21. PubMed
PMID: 29574077.


13: Kahaly GJ, Frommer L, Schuppan D. Celiac disease and endocrine autoimmunity -
the genetic link. Autoimmun Rev. 2018 Dec;17(12):1169-1175. doi:
10.1016/j.autrev.2018.05.013. Epub 2018 Oct 12. Review. PubMed PMID: 30316996.


14: Schink A, Naumoska K, Kitanovski Z, Kampf CJ, Fröhlich-Nowoisky J, Thines E,
Pöschl U, Schuppan D, Lucas K. Anti-inflammatory effects of cinnamon extract and
identification of active compounds influencing the TLR2 and TLR4 signaling
pathways. Food Funct. 2018 Nov 14;9(11):5950-5964. doi: 10.1039/c8fo01286e.
PubMed PMID: 30379176.


15: Labenz C, Huber Y, Kalliga E, Nagel M, Ruckes C, Straub BK, Galle PR, Wörns
MA, Anstee QM, Schuppan D, Schattenberg JM. Predictors of advanced fibrosis in
non-cirrhotic non-alcoholic fatty liver disease in Germany. Aliment Pharmacol
Ther. 2018 Nov;48(10):1109-1116. doi: 10.1111/apt.14976. Epub 2018 Oct 4. PubMed
PMID: 30288767.


16: Schink A, Neumann J, Leifke AL, Ziegler K, Fröhlich-Nowoisky J, Cremer C,
Thines E, Weber B, Pöschl U, Schuppan D, Lucas K. Screening of herbal extracts
for TLR2- and TLR4-dependent anti-inflammatory effects. PLoS One. 2018 Oct
11;13(10):e0203907. doi: 10.1371/journal.pone.0203907. eCollection 2018. PubMed
PMID: 30307962; PubMed Central PMCID: PMC6181297.


17: Rosigkeit S, Meng M, Grunwitz C, Gomes P, Kreft A, Hayduk N, Heck R, Pickert
G, Ziegler K, Abassi Y, Röder J, Kaps L, Vascotto F, Beissert T, Witzel S, Kuhn
A, Diken M, Schuppan D, Sahin U, Haas H, Bockamp E. Monitoring Translation
Activity of mRNA-Loaded Nanoparticles in Mice. Mol Pharm. 2018 Sep
4;15(9):3909-3919. doi: 10.1021/acs.molpharmaceut.8b00370. Epub 2018 Aug 9.
PubMed PMID: 30028629.


18: Ludvigsson JF, Ciacci C, Green PH, Kaukinen K, Korponay-Szabo IR, Kurppa K,
Murray JA, Lundin KEA, Maki MJ, Popp A, Reilly NR, Rodriguez-Herrera A, Sanders
DS, Schuppan D, Sleet S, Taavela J, Voorhees K, Walker MM, Leffler DA. Outcome
measures in coeliac disease trials: the Tampere recommendations. Gut. 2018
Aug;67(8):1410-1424. doi: 10.1136/gutjnl-2017-314853. Epub 2018 Feb 13. PubMed
PMID: 29440464; PubMed Central PMCID: PMC6204961.


19: Schuppan D, Ashfaq-Khan M, Yang AT, Kim YO. Liver fibrosis: Direct
antifibrotic agents and targeted therapies. Matrix Biol. 2018 Aug;68-69:435-451.
doi: 10.1016/j.matbio.2018.04.006. Epub 2018 Apr 12. Review. PubMed PMID:
29656147.


20: Hintermann E, Bayer M, Conti CB, Fuchs S, Fausther M, Leung PS, Aurrand-Lions
M, Taubert R, Pfeilschifter JM, Friedrich-Rust M, Schuppan D, Dranoff JA,
Gershwin ME, Manns MP, Imhof BA, Christen U. Junctional adhesion molecules JAM-B
and JAM-C promote autoimmune-mediated liver fibrosis in mice. J Autoimmun. 2018
Jul;91:83-96. doi: 10.1016/j.jaut.2018.05.001. Epub 2018 May 9. PubMed PMID:
29753567.


21: Kahaly GJ, Frommer L, Schuppan D. Celiac Disease and Glandular Autoimmunity.
Nutrients. 2018 Jun 25;10(7). pii: E814. doi: 10.3390/nu10070814. Review. PubMed
PMID: 29941778; PubMed Central PMCID: PMC6073228.


22: Hofmann SR, Laass MW, Fehrs A, Schuppan D, Zevallos VF, Salminger D, Mäbert
K, Hedrich CM. IL10 promoter haplotypes may contribute to altered cytokine
expression and systemic inflammation in celiac disease. Clin Immunol. 2018
May;190:15-21. doi: 10.1016/j.clim.2018.02.010. Epub 2018 Feb 24. PubMed PMID:
29481982.


23: Zevallos VF, Raker VK, Maxeiner J, Scholtes P, Steinbrink K, Schuppan D.
Dietary wheat amylase trypsin inhibitors exacerbate murine allergic airway
inflammation. Eur J Nutr. 2018 Mar 29. doi: 10.1007/s00394-018-1681-6. [Epub
ahead of print] PubMed PMID: 29600329.


24: Foerster F, Hess M, Gerhold-Ay A, Marquardt JU, Becker D, Galle PR, Schuppan
D, Binder H, Bockamp E. The immune contexture of hepatocellular carcinoma
predicts clinical outcome. Sci Rep. 2018 Mar 29;8(1):5351. doi:
10.1038/s41598-018-21937-2. PubMed PMID: 29599491; PubMed Central PMCID:
PMC5876395.


25: Christensen CU, Glavind E, Thomsen KL, Kim YO, Heebøll S, Schuppan D,
Hamilton-Dutoit S, Würtz Heegaard C, Grønbæk H. Niemann-Pick type C2 protein
supplementation in experimental non-alcoholic fatty liver disease. PLoS One. 2018
Mar 9;13(3):e0192728. doi: 10.1371/journal.pone.0192728. eCollection 2018. PubMed
PMID: 29522534; PubMed Central PMCID: PMC5844539.


26: Weng SY, Wang X, Vijayan S, Tang Y, Kim YO, Padberg K, Regen T, Molokanova O,
Chen T, Bopp T, Schild H, Brombacher F, Crosby JR, McCaleb ML, Waisman A, Bockamp
E, Schuppan D. IL-4 Receptor Alpha Signaling through Macrophages Differentially
Regulates Liver Fibrosis Progression and Reversal. EBioMedicine. 2018
Mar;29:92-103. doi: 10.1016/j.ebiom.2018.01.028. Epub 2018 Feb 17. PubMed PMID:
29463471; PubMed Central PMCID: PMC5925448.


27: Molokanova O, Schönig K, Weng SY, Wang X, Bros M, Diken M, Ohngemach S,
Karsdal M, Strand D, Nikolaev A, Eshkind L, Schuppan D. Inducible knockdown of
procollagen I protects mice from liver fibrosis and leads to dysregulated matrix
genes and attenuated inflammation. Matrix Biol. 2018 Mar;66:34-49. doi:
10.1016/j.matbio.2017.11.002. Epub 2017 Nov 6. PubMed PMID: 29122677.


28: Schuppan D, Surabattula R, Wang XY. Determinants of fibrosis progression and
regression in NASH. J Hepatol. 2018 Feb;68(2):238-250. doi:
10.1016/j.jhep.2017.11.012. Epub 2017 Nov 14. Review. PubMed PMID: 29154966.


29: Stein J, Schulzke JD, Schuppan D. [Drug therapy in coeliac disease - "from
bench to bedside"]. Z Gastroenterol. 2018 Feb;56(2):151-164. doi:
10.1055/s-0043-121345. Epub 2017 Nov 7. German. PubMed PMID: 29113008.


30: Lang-Yona N, Kunert AT, Vogel L, Kampf CJ, Bellinghausen I, Saloga J, Schink
A, Ziegler K, Lucas K, Schuppan D, Pöschl U, Weber B, Fröhlich-Nowoisky J. Fresh
water, marine and terrestrial cyanobacteria display distinct allergen
characteristics. Sci Total Environ. 2018 Jan 15;612:767-774. doi:
10.1016/j.scitotenv.2017.08.069. Epub 2017 Sep 1. PubMed PMID: 28866404.


31: Wang X, Hausding M, Weng SY, Kim YO, Steven S, Klein T, Daiber A, Schuppan D.
Gliptins Suppress Inflammatory Macrophage Activation to Mitigate Inflammation,
Fibrosis, Oxidative Stress, and Vascular Dysfunction in Models of Nonalcoholic
Steatohepatitis and Liver Fibrosis. Antioxid Redox Signal. 2018 Jan
10;28(2):87-109. doi: 10.1089/ars.2016.6953. Epub 2017 Jul 25. PubMed PMID:
28635324.


32: van Dijk F, Teekamp N, Beljaars L, Post E, Zuidema J, Steendam R, Kim YO,
Frijlink HW, Schuppan D, Poelstra K, Hinrichs WLJ, Olinga P. Pharmacokinetics of
a sustained release formulation of PDGFβ-receptor directed carrier proteins to
target the fibrotic liver. J Control Release. 2018 Jan 10;269:258-265. doi:
10.1016/j.jconrel.2017.11.029. Epub 2017 Nov 21. PubMed PMID: 29170138.


33: Foerster F, Boegel S, Heck R, Pickert G, Rüssel N, Rosigkeit S, Bros M,
Strobl S, Kaps L, Aslam M, Diken M, Castle J, Sahin U, Tuettenberg A, Bockamp E,
Schuppan D. Enhanced protection of C57 BL/6 vs Balb/c mice to melanoma liver
metastasis is mediated by NK cells. Oncoimmunology. 2017 Dec 26;7(4):e1409929.
doi: 10.1080/2162402X.2017.1409929. eCollection 2018. PubMed PMID: 29632723;
PubMed Central PMCID: PMC5889278.


34: Vollmar J, Lautem A, Closs E, Schuppan D, Kim YO, Grimm D, Marquardt JU,
Fuchs P, Straub BK, Schad A, Gründemann D, Schattenberg JM, Gehrke N, Wörns MA,
Baumgart J, Galle PR, Zimmermann T. Loss of organic cation transporter 3 (Oct3)
leads to enhanced proliferation and hepatocarcinogenesis. Oncotarget. 2017 Dec
18;8(70):115667-115680. doi: 10.18632/oncotarget.23372. eCollection 2017 Dec 29.
PubMed PMID: 29383190; PubMed Central PMCID: PMC5777802.


35: Hughey JJ, Ray BK, Lee AR, Voorhees KN, Kelly CP, Schuppan D. Self-reported
dietary adherence, disease-specific symptoms, and quality of life are associated
with healthcare provider follow-up in celiac disease. BMC Gastroenterol. 2017 Dec
11;17(1):156. doi: 10.1186/s12876-017-0713-7. PubMed PMID: 29228908; PubMed
Central PMCID: PMC5725827.


36: Catassi C, Alaedini A, Bojarski C, Bonaz B, Bouma G, Carroccio A, Castillejo
G, De Magistris L, Dieterich W, Di Liberto D, Elli L, Fasano A, Hadjivassiliou M,
Kurien M, Lionetti E, Mulder CJ, Rostami K, Sapone A, Scherf K, Schuppan D, Trott
N, Volta U, Zevallos V, Zopf Y, Sanders DS. The Overlapping Area of Non-Celiac
Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An
Update. Nutrients. 2017 Nov 21;9(11). pii: E1268. doi: 10.3390/nu9111268. Review.
PubMed PMID: 29160841; PubMed Central PMCID: PMC5707740.


37: Schupp J, Krebs FK, Zimmer N, Trzeciak E, Schuppan D, Tuettenberg A.
Targeting myeloid cells in the tumor sustaining microenvironment. Cell Immunol.
2017 Nov 2. pii: S0008-8749(17)30190-9. doi: 10.1016/j.cellimm.2017.10.013. [Epub
ahead of print] Review. PubMed PMID: 29129292.


38: Karsdal MA, Nielsen SH, Leeming DJ, Langholm LL, Nielsen MJ, Manon-Jensen T,
Siebuhr A, Gudmann NS, Rønnow S, Sand JM, Daniels SJ, Mortensen JH, Schuppan D.
The good and the bad collagens of fibrosis - Their role in signaling and organ
function. Adv Drug Deliv Rev. 2017 Nov 1;121:43-56. doi:
10.1016/j.addr.2017.07.014. Epub 2017 Jul 21. Review. PubMed PMID: 28736303.


39: Isokuortti E, Zhou Y, Peltonen M, Bugianesi E, Clement K, Bonnefont-Rousselot
D, Lacorte JM, Gastaldelli A, Schuppan D, Schattenberg JM, Hakkarainen A, Lundbom
N, Jousilahti P, Männistö S, Keinänen-Kiukaanniemi S, Saltevo J, Anstee QM,
Yki-Järvinen H. Use of HOMA-IR to diagnose non-alcoholic fatty liver disease: a
population-based and inter-laboratory study. Diabetologia. 2017
Oct;60(10):1873-1882. doi: 10.1007/s00125-017-4340-1. Epub 2017 Jun 29. PubMed
PMID: 28660493.


40: Luangmonkong T, Suriguga S, Bigaeva E, Boersema M, Oosterhuis D, de Jong KP,
Schuppan D, Mutsaers HAM, Olinga P. Evaluating the antifibrotic potency of
galunisertib in a human ex vivo model of liver fibrosis. Br J Pharmacol. 2017
Sep;174(18):3107-3117. doi: 10.1111/bph.13945. Epub 2017 Aug 11. PubMed PMID:
28691737; PubMed Central PMCID: PMC5573419.


41: Ikenaga N, Peng ZW, Vaid KA, Liu SB, Yoshida S, Sverdlov DY, Mikels-Vigdal A,
Smith V, Schuppan D, Popov YV. Selective targeting of lysyl oxidase-like 2
(LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal.
Gut. 2017 Sep;66(9):1697-1708. doi: 10.1136/gutjnl-2016-312473. Epub 2017 Jan 10.
PubMed PMID: 28073888; PubMed Central PMCID: PMC5561383.


42: Chen T, Zhu L, Shi A, Ding L, Zhang X, Tan Z, Guo W, Yan W, Han M, Jia J, Luo
X, Schuppan D, Ning Q. Functional restoration of CD56(bright) NK cells
facilitates immune control via IL-15 and NKG2D in patients under antiviral
treatment for chronic hepatitis B. Hepatol Int. 2017 Sep;11(5):419-428. doi:
10.1007/s12072-017-9803-4. Epub 2017 Jun 20. PubMed PMID: 28639033; PubMed
Central PMCID: PMC5606950.


43: Haeberle S, Raker V, Haub J, Kim YO, Weng SY, Yilmaz OK, Enk A, Steinbrink K,
Schuppan D, Hadaschik EN. Regulatory T cell deficient scurfy mice exhibit a
Th2/M2-like inflammatory response in the skin. J Dermatol Sci. 2017
Sep;87(3):285-291. doi: 10.1016/j.jdermsci.2017.07.001. Epub 2017 Jul 13. PubMed
PMID: 28811075.


44: Raker V, Haub J, Stojanovic A, Cerwenka A, Schuppan D, Steinbrink K. Early
inflammatory players in cutanous fibrosis. J Dermatol Sci. 2017
Sep;87(3):228-235. doi: 10.1016/j.jdermsci.2017.06.009. Epub 2017 Jun 15. Review.
PubMed PMID: 28655471.


45: Ackermann M, Kim YO, Wagner WL, Schuppan D, Valenzuela CD, Mentzer SJ, Kreuz
S, Stiller D, Wollin L, Konerding MA. Effects of nintedanib on the microvascular
architecture in a lung fibrosis model. Angiogenesis. 2017 Aug;20(3):359-372. doi:
10.1007/s10456-017-9543-z. Epub 2017 Mar 10. PubMed PMID: 28283856.


46: Julich-Haertel H, Urban SK, Krawczyk M, Willms A, Jankowski K, Patkowski W,
Kruk B, Krasnodębski M, Ligocka J, Schwab R, Richardsen I, Schaaf S, Klein A,
Gehlert S, Sänger H, Casper M, Banales JM, Schuppan D, Milkiewicz P, Lammert F,
Krawczyk M, Lukacs-Kornek V, Kornek M. Cancer-associated circulating large
extracellular vesicles in cholangiocarcinoma and hepatocellular carcinoma. J
Hepatol. 2017 Aug;67(2):282-292. doi: 10.1016/j.jhep.2017.02.024. Epub 2017 Mar
6. PubMed PMID: 28267620.


47: Fleck AK, Schuppan D, Wiendl H, Klotz L. Gut-CNS-Axis as Possibility to
Modulate Inflammatory Disease Activity-Implications for Multiple Sclerosis. Int J
Mol Sci. 2017 Jul 14;18(7). pii: E1526. doi: 10.3390/ijms18071526. Review. PubMed
PMID: 28708108; PubMed Central PMCID: PMC5536015.


48: Huber Y, Gehrke N, Biedenbach J, Helmig S, Simon P, Straub BK, Bergheim I,
Huber T, Schuppan D, Galle PR, Wörns MA, Schuchmann M, Schattenberg JM. Voluntary
distance running prevents TNF-mediated liver injury in mice through alterations
of the intrahepatic immune milieu. Cell Death Dis. 2017 Jun 22;8(6):e2893. doi:
10.1038/cddis.2017.266. PubMed PMID: 28640248; PubMed Central PMCID: PMC5520921.


49: Lackner C, Bataller R, Burt A, Miquel R, Schuppan D, Tiniakos D, Trauner M.
Fibrosis evaluation by transient elastography in alcoholic liver disease: Is the
histological scoring system impacting cutoff values? Hepatology. 2017
May;65(5):1758-1761. doi: 10.1002/hep.29075. Epub 2017 Apr 3. PubMed PMID:
28120459.


50: Reinmuth-Selzle K, Kampf CJ, Lucas K, Lang-Yona N, Fröhlich-Nowoisky J,
Shiraiwa M, Lakey PSJ, Lai S, Liu F, Kunert AT, Ziegler K, Shen F, Sgarbanti R,
Weber B, Bellinghausen I, Saloga J, Weller MG, Duschl A, Schuppan D, Pöschl U.
Air Pollution and Climate Change Effects on Allergies in the Anthropocene:
Abundance, Interaction, and Modification of Allergens and Adjuvants. Environ Sci
Technol. 2017 Apr 18;51(8):4119-4141. doi: 10.1021/acs.est.6b04908. Epub 2017 Apr
6. PubMed PMID: 28326768; PubMed Central PMCID: PMC5453620.


51: Zevallos VF, Raker V, Tenzer S, Jimenez-Calvente C, Ashfaq-Khan M, Rüssel N,
Pickert G, Schild H, Steinbrink K, Schuppan D. Nutritional Wheat Amylase-Trypsin
Inhibitors Promote Intestinal Inflammation via Activation of Myeloid Cells.
Gastroenterology. 2017 Apr;152(5):1100-1113.e12. doi:
10.1053/j.gastro.2016.12.006. Epub 2016 Dec 16. PubMed PMID: 27993525.


52: Tian N, Faller L, Leffler DA, Kelly CP, Hansen J, Bosch JA, Wei G, Paster BJ,
Schuppan D, Helmerhorst EJ. Salivary Gluten Degradation and Oral Microbial
Profiles in Healthy Individuals and Celiac Disease Patients. Appl Environ
Microbiol. 2017 Mar 2;83(6). pii: e03330-16. doi: 10.1128/AEM.03330-16. Print
2017 Mar 15. PubMed PMID: 28087531; PubMed Central PMCID: PMC5335528.


53: Tanwar S, Trembling PM, Hogan BJ, Srivastava A, Parkes J, Harris S, Grant P,
Nastouli E, Ocker M, Wehr K, Herold C, Neureiter D, Schuppan D, Rosenberg WM.
Noninvasive markers of liver fibrosis: on-treatment changes of serum markers
predict the outcome of antifibrotic therapy. Eur J Gastroenterol Hepatol. 2017
Mar;29(3):289-296. doi: 10.1097/MEG.0000000000000789. PubMed PMID: 27906753.


54: Tanwar S, Trembling PM, Hogan BJ, Parkes J, Harris S, Grant P, Nastouli E,
Ocker M, Wehr K, Herold C, Neureiter D, Schuppan D, Rosenberg WM. Biomarkers of
Hepatic Fibrosis in Chronic Hepatitis C: A Comparison of 10 Biomarkers Using 2
Different Assays for Hyaluronic Acid. J Clin Gastroenterol. 2017
Mar;51(3):268-277. doi: 10.1097/MCG.0000000000000581. PubMed PMID: 27380461.


55: Leber N, Kaps L, Aslam M, Schupp J, Brose A, Schäffel D, Fischer K, Diken M,
Strand D, Koynov K, Tuettenberg A, Nuhn L, Zentel R, Schuppan D. SiRNA-mediated
in vivo gene knockdown by acid-degradable cationic nanohydrogel particles. J
Control Release. 2017 Feb 28;248:10-23. doi: 10.1016/j.jconrel.2016.12.006. Epub
2016 Dec 9. PubMed PMID: 27940184.


56: Reiss-Pistilli ML, Schuppan D, Barroso MM, Assunção-Miranda I, Farias S, Lery
L, Bauer M, Juliano L, Juliano MA, Coelho-Sampaio T. An extracellular proteasome
releases endostatin from human collagen XVIII. Angiogenesis. 2017
Feb;20(1):125-137. doi: 10.1007/s10456-016-9533-6. Epub 2016 Dec 5. PubMed PMID:
27921229.


57: Karsdal MA, Henriksen K, Genovese F, Leeming DJ, Nielsen MJ, Riis BJ,
Christiansen C, Byrjalsen I, Schuppan D. Serum endotrophin identifies optimal
responders to PPARγ agonists in type 2 diabetes. Diabetologia. 2017
Jan;60(1):50-59. Epub 2016 Sep 8. PubMed PMID: 27631136.


58: Kim YO, Popov Y, Schuppan D. Optimized Mouse Models for Liver Fibrosis.
Methods Mol Biol. 2017;1559:279-296. doi: 10.1007/978-1-4939-6786-5_19. PubMed
PMID: 28063051.


59: Muenzner JK, Biersack B, Albrecht A, Rehm T, Lacher U, Milius W, Casini A,
Zhang JJ, Ott I, Brabec V, Stuchlikova O, Andronache IC, Kaps L, Schuppan D,
Schobert R. Ferrocenyl-Coupled N-Heterocyclic Carbene Complexes of Gold(I): A
Successful Approach to Multinuclear Anticancer Drugs. Chemistry. 2016 Dec
23;22(52):18953-18962. doi: 10.1002/chem.201604246. Epub 2016 Nov 17. PubMed
PMID: 27761940.


60: Nielsen MJ, Karsdal MA, Kazankov K, Grønbaek H, Krag A, Leeming DJ, Schuppan
D, George J. Fibrosis is not just fibrosis - basement membrane modelling and
collagen metabolism differs between hepatitis B- and C-induced injury. Aliment
Pharmacol Ther. 2016 Dec;44(11-12):1242-1252. doi: 10.1111/apt.13819. Epub 2016
Oct 3. PubMed PMID: 27696451.


61: Karsdal MA, Henriksen K, Nielsen MJ, Byrjalsen I, Leeming DJ, Gardner S,
Goodman Z, Patel K, Krag A, Christiansen C, Schuppan D. Fibrogenesis assessed by
serological type III collagen formation identifies patients with progressive
liver fibrosis and responders to a potential antifibrotic therapy. Am J Physiol
Gastrointest Liver Physiol. 2016 Dec 1;311(6):G1009-G1017. doi:
10.1152/ajpgi.00283.2016. Epub 2016 Oct 20. PubMed PMID: 27765759.


62: Gehrke N, Wörns MA, Huber Y, Hess M, Straub BK, Hövelmeyer N, Waisman A, Kim
YO, Schuppan D, Galle PR, Schattenberg JM. Hepatic B cell leukemia-3 promotes
hepatic steatosis and inflammation through insulin-sensitive metabolic
transcription factors. J Hepatol. 2016 Dec;65(6):1188-1197. doi:
10.1016/j.jhep.2016.06.026. Epub 2016 Jul 9. PubMed PMID: 27405060.


63: Müller LK, Kaps L, Schuppan D, Brose A, Chai W, Fischer K, Müller S, Frey H,
Schmidt M, Mohr K. Physicochemical and Preclinical Evaluation of Spermine-Derived
Surfactant Liposomes for in Vitro and in Vivo siRNA-Delivery to Liver
Macrophages. Mol Pharm. 2016 Nov 7;13(11):3636-3647. Epub 2016 Oct 18. PubMed
PMID: 27700112.


64: Raker VK, Ook KY, Haub J, Lorenz N, Schmidt T, Stegemann A, Böhm M, Schuppan
D, Steinbrink K. Myeloid cell populations and fibrogenic parameters in bleomycin-
and HOCl-induced fibrosis. Exp Dermatol. 2016 Nov;25(11):887-894. doi:
10.1111/exd.13124. PubMed PMID: 27307019.


65: Qureshi MA, Kim YO, Schuppan D. Hepatocellular carcinoma in nonalcoholic
fatty liver disease: A link between oxidative stress and T-cell suppression.
Hepatology. 2016 Nov;64(5):1794-1797. doi: 10.1002/hep.28815. PubMed PMID:
27629157.


66: Waisman A, Hövelmeyer N, Diefenbach A, Schuppan D, Reddehase MJ, Kleinert H,
Kaina B, Grabbe S, Galle PR, Theobald M, Zipp F, Sahin U, Türeci Ö, Kreiter S,
Langguth P, Decker H, van Zandbergen G, Schild H. Past, present and future of
immunology in Mainz. Cell Immunol. 2016 Oct;308:1-6. doi:
10.1016/j.cellimm.2016.09.001. PubMed PMID: 27719802.


67: Caminero A, Galipeau HJ, McCarville JL, Johnston CW, Bernier SP, Russell AK,
Jury J, Herran AR, Casqueiro J, Tye-Din JA, Surette MG, Magarvey NA, Schuppan D,
Verdu EF. Duodenal Bacteria From Patients With Celiac Disease and Healthy
Subjects Distinctly Affect Gluten Breakdown and Immunogenicity. Gastroenterology.
2016 Oct;151(4):670-83. doi: 10.1053/j.gastro.2016.06.041. Epub 2016 Jun 30.
PubMed PMID: 27373514.


68: Tuettenberg A, Steinbrink K, Schuppan D. Myeloid cells as orchestrators of
the tumor microenvironment: novel targets for nanoparticular cancer therapy.
Nanomedicine (Lond). 2016 Oct;11(20):2735-2751. Epub 2016 Sep 23. Review. PubMed
PMID: 27658725.


69: Grabbe S, Landfester K, Schuppan D, Barz M, Zentel R. Nanoparticles and the
immune system: challenges and opportunities. Nanomedicine (Lond). 2016
Oct;11(20):2621-2624. Epub 2016 Sep 20. PubMed PMID: 27649323.


70: Foerster F, Bamberger D, Schupp J, Weilbächer M, Kaps L, Strobl S, Radi L,
Diken M, Strand D, Tuettenberg A, Wich PR, Schuppan D. Dextran-based therapeutic
nanoparticles for hepatic drug delivery. Nanomedicine (Lond). 2016
Oct;11(20):2663-2677. Epub 2016 Sep 15. PubMed PMID: 27628057.


71: Wei G, Tian N, Siezen R, Schuppan D, Helmerhorst EJ. Identification of
food-grade subtilisins as gluten-degrading enzymes to treat celiac disease. Am J
Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G571-80. doi:
10.1152/ajpgi.00185.2016. Epub 2016 Jul 28. PubMed PMID: 27469368; PubMed Central
PMCID: PMC5076000.


72: Teufel A, Itzel T, Erhart W, Brosch M, Wang XY, Kim YO, von Schönfels W,
Herrmann A, Brückner S, Stickel F, Dufour JF, Chavakis T, Hellerbrand C, Spang R,
Maass T, Becker T, Schreiber S, Schafmayer C, Schuppan D, Hampe J. Comparison of
Gene Expression Patterns Between Mouse Models of Nonalcoholic Fatty Liver Disease
and Liver Tissues From Patients. Gastroenterology. 2016 Sep;151(3):513-525.e0.
doi: 10.1053/j.gastro.2016.05.051. Epub 2016 Jun 16. PubMed PMID: 27318147.


73: Hahn SA, Neuhoff A, Landsberg J, Schupp J, Eberts D, Leukel P, Bros M,
Weilbaecher M, Schuppan D, Grabbe S, Tueting T, Lennerz V, Sommer C, Jonuleit H,
Tuettenberg A. A key role of GARP in the immune suppressive tumor
microenvironment. Oncotarget. 2016 Jul 12;7(28):42996-43009. doi:
10.18632/oncotarget.9598. PubMed PMID: 27248166; PubMed Central PMCID:
PMC5190003.


74: Hocher B, Haumann H, Rahnenführer J, Reichetzeder C, Kalk P, Pfab T,
Tsuprykov O, Winter S, Hofmann U, Li J, Püschel GP, Lang F, Schuppan D, Schwab M,
Schaeffeler E. Maternal eNOS deficiency determines a fatty liver phenotype of the
offspring in a sex dependent manner. Epigenetics. 2016 Jul 2;11(7):539-52. doi:
10.1080/15592294.2016.1184800. Epub 2016 May 13. PubMed PMID: 27175980; PubMed
Central PMCID: PMC4939931.


75: Adriaanse MP, Leffler DA, Kelly CP, Schuppan D, Najarian RM, Goldsmith JD,
Buurman WA, Vreugdenhil AC. Serum I-FABP Detects Gluten Responsiveness in Adult
Celiac Disease Patients on a Short-Term Gluten Challenge. Am J Gastroenterol.
2016 Jul;111(7):1014-22. doi: 10.1038/ajg.2016.162. Epub 2016 May 17. PubMed
PMID: 27185075.


76: Schuppan D. [Celiac disease : Pathogenesis, clinics, epidemiology,
diagnostics, therapy]. Bundesgesundheitsblatt Gesundheitsforschung
Gesundheitsschutz. 2016 Jul;59(7):827-35. doi: 10.1007/s00103-016-2364-1. Review.
German. PubMed PMID: 27273303.


77: Nuhn L, Kaps L, Diken M, Schuppan D, Zentel R. Reductive Decationizable Block
Copolymers for Stimuli-Responsive mRNA Delivery. Macromol Rapid Commun. 2016
Jun;37(11):924-33. doi: 10.1002/marc.201600046. Epub 2016 Apr 14. PubMed PMID:
27075781.


78: Willms A, Müller C, Julich H, Klein N, Schwab R, Güsgen C, Richardsen I,
Schaaf S, Krawczyk M, Krawczyk M, Lammert F, Schuppan D, Lukacs-Kornek V, Kornek
M. Tumour-associated circulating microparticles: A novel liquid biopsy tool for
screening and therapy monitoring of colorectal carcinoma and other epithelial
neoplasia. Oncotarget. 2016 May 24;7(21):30867-75. doi: 10.18632/oncotarget.9018.
PubMed PMID: 27127176; PubMed Central PMCID: PMC5058724.


79: Landefeld C, Kentouche K, Gruhn B, Stauch T, Rößler S, Schuppan D, Whatley
SD, Beck JF, Stölzel U. X-linked protoporphyria: Iron supplementation improves
protoporphyrin overload, liver damage and anaemia. Br J Haematol. 2016
May;173(3):482-4. doi: 10.1111/bjh.13612. Epub 2015 Jul 20. PubMed PMID:
26193873.


80: Liu SB, Ikenaga N, Peng ZW, Sverdlov DY, Greenstein A, Smith V, Schuppan D,
Popov Y. Lysyl oxidase activity contributes to collagen stabilization during
liver fibrosis progression and limits spontaneous fibrosis reversal in mice.
FASEB J. 2016 Apr;30(4):1599-609. doi: 10.1096/fj.14-268425. Epub 2015 Dec 23.
PubMed PMID: 26700732.


81: Bernuth S, Yagmur E, Schuppan D, Sprinzl MF, Zimmermann A, Schad A, Kittner
JM, Weyer V, Knapstein J, Schattenberg JM, Wörns MA, Galle PR, Zimmermann T.
Early changes in dynamic biomarkers of liver fibrosis in hepatitis C
virus-infected patients treated with sofosbuvir. Dig Liver Dis. 2016
Mar;48(3):291-7. doi: 10.1016/j.dld.2015.09.015. Epub 2015 Oct 3. PubMed PMID:
26514736.


82: Locatelli L, Cadamuro M, Spirlì C, Fiorotto R, Lecchi S, Morell CM, Popov Y,
Scirpo R, De Matteis M, Amenduni M, Pietrobattista A, Torre G, Schuppan D, Fabris
L, Strazzabosco M. Macrophage recruitment by fibrocystin-defective biliary
epithelial cells promotes portal fibrosis in congenital hepatic fibrosis.
Hepatology. 2016 Mar;63(3):965-82. doi: 10.1002/hep.28382. Epub 2016 Jan 16.
PubMed PMID: 26645994; PubMed Central PMCID: PMC4764460.


83: Eckert C, Kim YO, Julich H, Heier EC, Klein N, Krause E, Tschernig T, Kornek
M, Lammert F, Schuppan D, Lukacs-Kornek V. Podoplanin discriminates distinct
stromal cell populations and a novel progenitor subset in the liver. Am J Physiol
Gastrointest Liver Physiol. 2016 Jan 1;310(1):G1-12. doi:
10.1152/ajpgi.00344.2015. Epub 2015 Nov 12. PubMed PMID: 26564718; PubMed Central
PMCID: PMC4698439.


84: Behm B, Di Fazio P, Michl P, Neureiter D, Kemmerling R, Hahn EG, Strobel D,
Gress T, Schuppan D, Wissniowski TT. Additive antitumour response to the rabbit
VX2 hepatoma by combined radio frequency ablation and toll like receptor 9
stimulation. Gut. 2016 Jan;65(1):134-43. doi: 10.1136/gutjnl-2014-308286. Epub
2014 Dec 18. PubMed PMID: 25524262.


85: Peng ZW, Ikenaga N, Liu SB, Sverdlov DY, Vaid KA, Dixit R, Weinreb PH,
Violette S, Sheppard D, Schuppan D, Popov Y. Integrin αvβ6 critically regulates
hepatic progenitor cell function and promotes ductular reaction, fibrosis, and
tumorigenesis. Hepatology. 2016 Jan;63(1):217-32. doi: 10.1002/hep.28274. Epub
2015 Nov 23. PubMed PMID: 26448099; PubMed Central PMCID: PMC5312042.


86: Karsdal MA, Genovese F, Madsen EA, Manon-Jensen T, Schuppan D. Collagen and
tissue turnover as a function of age: Implications for fibrosis. J Hepatol. 2016
Jan;64(1):103-9. doi: 10.1016/j.jhep.2015.08.014. Epub 2015 Aug 22. PubMed PMID:
26307398.


87: Kaps L, Nuhn L, Aslam M, Brose A, Foerster F, Rosigkeit S, Renz P, Heck R,
Kim YO, Lieberwirth I, Schuppan D, Zentel R. In Vivo Gene-Silencing in Fibrotic
Liver by siRNA-Loaded Cationic Nanohydrogel Particles. Adv Healthc Mater. 2015
Dec 30;4(18):2809-15. doi: 10.1002/adhm.201500826. Epub 2015 Dec 2. PubMed PMID:
26627192.


88: Tian N, Leffler DA, Kelly CP, Hansen J, Marietta EV, Murray JA, Schuppan D,
Helmerhorst EJ. Despite sequence homologies to gluten, salivary proline-rich
proteins do not elicit immune responses central to the pathogenesis of celiac
disease. Am J Physiol Gastrointest Liver Physiol. 2015 Dec 1;309(11):G910-7. doi:
10.1152/ajpgi.00157.2015. Epub 2015 Oct 1. PubMed PMID: 26505973; PubMed Central
PMCID: PMC4669355.


89: Jiménez Calvente C, Sehgal A, Popov Y, Kim YO, Zevallos V, Sahin U, Diken M,
Schuppan D. Specific hepatic delivery of procollagen α1(I) small interfering RNA
in lipid-like nanoparticles resolves liver fibrosis. Hepatology. 2015
Oct;62(4):1285-97. doi: 10.1002/hep.27936. Epub 2015 Aug 28. PubMed PMID:
26096209; PubMed Central PMCID: PMC4589454.


90: Tian N, Messana I, Leffler DA, Kelly CP, Hansen J, Cabras T, D'Alessandro A,
Schuppan D, Castagnola M, Helmerhorst EJ. Salivary proline-rich proteins and
gluten: Do structural similarities suggest a role in celiac disease? Proteomics
Clin Appl. 2015 Oct;9(9-10):953-64. doi: 10.1002/prca.201400170. Epub 2015 Apr
24. PubMed PMID: 25726832; PubMed Central PMCID: PMC4551613.


91: Schuppan D. Liver fibrosis: Common mechanisms and antifibrotic therapies.
Clin Res Hepatol Gastroenterol. 2015 Sep;39 Suppl 1:S51-9. doi:
10.1016/j.clinre.2015.05.005. Epub 2015 Jul 17. Review. PubMed PMID: 26189980.


92: Torok NJ, Dranoff JA, Schuppan D, Friedman SL. Strategies and endpoints of
antifibrotic drug trials: Summary and recommendations from the AASLD Emerging
Trends Conference, Chicago, June 2014. Hepatology. 2015 Aug;62(2):627-34. doi:
10.1002/hep.27720. Epub 2015 Mar 10. Review. PubMed PMID: 25626988; PubMed
Central PMCID: PMC4515973.


93: Catassi C, Elli L, Bonaz B, Bouma G, Carroccio A, Castillejo G, Cellier C,
Cristofori F, de Magistris L, Dolinsek J, Dieterich W, Francavilla R,
Hadjivassiliou M, Holtmeier W, Körner U, Leffler DA, Lundin KE, Mazzarella G,
Mulder CJ, Pellegrini N, Rostami K, Sanders D, Skodje GI, Schuppan D, Ullrich R,
Volta U, Williams M, Zevallos VF, Zopf Y, Fasano A. Diagnosis of Non-Celiac
Gluten Sensitivity (NCGS): The Salerno Experts' Criteria. Nutrients. 2015 Jun
18;7(6):4966-77. doi: 10.3390/nu7064966. PubMed PMID: 26096570; PubMed Central
PMCID: PMC4488826.


94: Wei G, Tian N, Valery AC, Zhong Y, Schuppan D, Helmerhorst EJ. Identification
of Pseudolysin (lasB) as an Aciduric Gluten-Degrading Enzyme with High
Therapeutic Potential for Celiac Disease. Am J Gastroenterol. 2015
Jun;110(6):899-908. doi: 10.1038/ajg.2015.97. Epub 2015 Apr 21. PubMed PMID:
25895519; PubMed Central PMCID: PMC4461489.


95: Schuppan D, Pickert G, Ashfaq-Khan M, Zevallos V. Non-celiac wheat
sensitivity: differential diagnosis, triggers and implications. Best Pract Res
Clin Gastroenterol. 2015 Jun;29(3):469-76. doi: 10.1016/j.bpg.2015.04.002. Epub
2015 May 8. Review. PubMed PMID: 26060111.


96: Karsdal MA, Manon-Jensen T, Genovese F, Kristensen JH, Nielsen MJ, Sand JM,
Hansen NU, Bay-Jensen AC, Bager CL, Krag A, Blanchard A, Krarup H, Leeming DJ,
Schuppan D. Novel insights into the function and dynamics of extracellular matrix
in liver fibrosis. Am J Physiol Gastrointest Liver Physiol. 2015 May
15;308(10):G807-30. doi: 10.1152/ajpgi.00447.2014. Epub 2015 Mar 12. Review.
PubMed PMID: 25767261; PubMed Central PMCID: PMC4437019.


97: Corley DA, Schuppan D. Food, the immune system, and the gastrointestinal
tract. Gastroenterology. 2015 May;148(6):1083-6. doi:
10.1053/j.gastro.2015.03.043. Epub 2015 Mar 30. PubMed PMID: 25835098; PubMed
Central PMCID: PMC4409565.


98: Fasano A, Sapone A, Zevallos V, Schuppan D. Nonceliac gluten sensitivity.
Gastroenterology. 2015 May;148(6):1195-204. doi: 10.1053/j.gastro.2014.12.049.
Epub 2015 Jan 9. Review. PubMed PMID: 25583468.


99: Mehal WZ, Schuppan D. Antifibrotic therapies in the liver. Semin Liver Dis.
2015 May;35(2):184-98. doi: 10.1055/s-0035-1550055. Epub 2015 May 14. Review.
PubMed PMID: 25974903; PubMed Central PMCID: PMC5743222.


100: Lindner U, Schuppan D, Schleithoff L, Habeck JO, Grodde T, Kirchhof K,
Stoelzel U. Aceruloplasminaemia: a family with a novel mutation and long-term
therapy with deferasirox. Horm Metab Res. 2015 Apr;47(4):303-8. doi:
10.1055/s-0034-1383650. Epub 2014 Aug 4. PubMed PMID: 25089372.


101: Jia J, Hou J, Ding H, Chen G, Xie Q, Wang Y, Zeng M, Zhao J, Wang T, Hu X,
Schuppan D. Transient elastography compared to serum markers to predict liver
fibrosis in a cohort of Chinese patients with chronic hepatitis B. J
Gastroenterol Hepatol. 2015 Apr;30(4):756-62. doi: 10.1111/jgh.12840. PubMed
PMID: 25353058.


102: Trautwein C, Friedman SL, Schuppan D, Pinzani M. Hepatic fibrosis: Concept
to treatment. J Hepatol. 2015 Apr;62(1 Suppl):S15-24. doi:
10.1016/j.jhep.2015.02.039. Review. PubMed PMID: 25920084.


103: Felber J, Stallmach A, Schuppan D. [Comment]. Z Gastroenterol. 2015
Apr;53(4):342-3. German. PubMed PMID: 26042232.


104: Stallmach A, Schuppan D. [Diagnostics and treatment of celiac disease].
Dtsch Med Wochenschr. 2015 Feb;140(3):198. doi: 10.1055/s-0041-100132. Epub 2015
Feb 6. Review. German. PubMed PMID: 25658409.


105: Nielsen MJ, Veidal SS, Karsdal MA, Ørsnes-Leeming DJ, Vainer B, Gardner SD,
Hamatake R, Goodman ZD, Schuppan D, Patel K. Plasma Pro-C3 (N-terminal type III
collagen propeptide) predicts fibrosis progression in patients with chronic
hepatitis C. Liver Int. 2015 Feb;35(2):429-37. doi: 10.1111/liv.12700. Epub 2014
Oct 29. PubMed PMID: 25308921.


106: Schuppan D, Zevallos V. Wheat amylase trypsin inhibitors as nutritional
activators of innate immunity. Dig Dis. 2015;33(2):260-3. doi: 10.1159/000371476.
Epub 2015 Apr 22. Review. PubMed PMID: 25925932.


107: Kahaly GJ, Schuppan D. Celiac disease and endocrine autoimmunity. Dig Dis.
2015;33(2):155-61. doi: 10.1159/000369535. Epub 2015 Apr 22. Review. PubMed PMID:
25925917.


108: Mulder CJ, Schuppan D. Small bowel: from sideline to center stage in
gastroenterology. Dig Dis. 2015;33(2):113-4. doi: 10.1159/000371650. Epub 2015
Apr 22. PubMed PMID: 25925910.


109: Kubisch I, de Albuquerque A, Schuppan D, Kaul S, Schaich M, Stölzel U.
Prognostic Role of a Multimarker Analysis of Circulating Tumor Cells in Advanced
Gastric and Gastroesophageal Adenocarcinomas. Oncology. 2015;89(5):294-303. doi:
10.1159/000437373. Epub 2015 Aug 28. PubMed PMID: 26315108.


110: Yoshida S, Ikenaga N, Liu SB, Peng ZW, Chung J, Sverdlov DY, Miyamoto M, Kim
YO, Ogawa S, Arch RH, Schuppan D, Popov Y. Extrahepatic platelet-derived growth
factor-β, delivered by platelets, promotes activation of hepatic stellate cells
and biliary fibrosis in mice. Gastroenterology. 2014 Dec;147(6):1378-92. doi:
10.1053/j.gastro.2014.08.038. Epub 2014 Aug 28. PubMed PMID: 25173753.


111: Fisher FM, Chui PC, Nasser IA, Popov Y, Cunniff JC, Lundasen T,
Kharitonenkov A, Schuppan D, Flier JS, Maratos-Flier E. Fibroblast growth factor
21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on
methionine and choline-deficient diets. Gastroenterology. 2014
Nov;147(5):1073-83.e6. doi: 10.1053/j.gastro.2014.07.044. Epub 2014 Jul 30.
PubMed PMID: 25083607; PubMed Central PMCID: PMC4570569.


112: Fritscher-Ravens A, Schuppan D, Ellrichmann M, Schoch S, Röcken C, Brasch J,
Bethge J, Böttner M, Klose J, Milla PJ. Confocal endomicroscopy shows
food-associated changes in the intestinal mucosa of patients with irritable bowel
syndrome. Gastroenterology. 2014 Nov;147(5):1012-20.e4. doi:
10.1053/j.gastro.2014.07.046. Epub 2014 Jul 30. PubMed PMID: 25083606.


113: Tian N, Wei G, Schuppan D, Helmerhorst EJ. Effect of Rothia mucilaginosa
enzymes on gliadin (gluten) structure, deamidation, and immunogenic epitopes
relevant to celiac disease. Am J Physiol Gastrointest Liver Physiol. 2014 Oct
15;307(8):G769-76. doi: 10.1152/ajpgi.00144.2014. Epub 2014 Aug 21. PubMed PMID:
25147233; PubMed Central PMCID: PMC4200315.


114: Ponto KA, Schuppan D, Zwiener I, Binder H, Mirshahi A, Diana T, Pitz S,
Pfeiffer N, Kahaly GJ. Thyroid-associated orbitopathy is linked to
gastrointestinal autoimmunity. Clin Exp Immunol. 2014 Oct;178(1):57-64. doi:
10.1111/cei.12395. PubMed PMID: 24903731; PubMed Central PMCID: PMC4360194.


115: Zhang L, Schuppan D. Traditional Chinese Medicine (TCM) for fibrotic liver
disease: hope and hype. J Hepatol. 2014 Jul;61(1):166-8. doi:
10.1016/j.jhep.2014.03.009. Epub 2014 Apr 26. Review. PubMed PMID: 24780816.


116: Felber J, Aust D, Baas S, Bischoff S, Bläker H, Daum S, Keller R, Koletzko
S, Laass M, Nothacker M, Roeb E, Schuppan D, Stallmach A. [Results of a
S2k-Consensus Conference of the German Society of Gastroenterolgy, Digestive- and
Metabolic Diseases (DGVS) in conjunction with the German Coeliac Society (DZG)
regarding coeliac disease, wheat allergy and wheat sensitivity]. Z Gastroenterol.
2014 Jul;52(7):711-43. doi: 10.1055/s-0034-1366687. Epub 2014 Jul 15. German.
PubMed PMID: 25026010.


117: Muenzner JK, Biersack B, Kalie H, Andronache IC, Kaps L, Schuppan D, Sasse
F, Schobert R. Gold(I) biscarbene complexes derived from vascular-disrupting
combretastatin A-4 address different targets and show antimetastatic potential.
ChemMedChem. 2014 Jun;9(6):1195-204. doi: 10.1002/cmdc.201400049. Epub 2014 Mar
19. PubMed PMID: 24648184.


118: Stein J, Schuppan D. Coeliac Disease - New Pathophysiological Findings and
Their Implications for Therapy. Viszeralmedizin. 2014 Jun;30(3):156-65. doi:
10.1159/000365099. Review. PubMed PMID: 26288589; PubMed Central PMCID:
PMC4513807.


119: Yang L, Kwon J, Popov Y, Gajdos GB, Ordog T, Brekken RA, Mukhopadhyay D,
Schuppan D, Bi Y, Simonetto D, Shah VH. Vascular endothelial growth factor
promotes fibrosis resolution and repair in mice. Gastroenterology. 2014
May;146(5):1339-50.e1. doi: 10.1053/j.gastro.2014.01.061. Epub 2014 Feb 4. PubMed
PMID: 24503129; PubMed Central PMCID: PMC4001704.


120: Zimmer KP, Schuppan D. In reply. Dtsch Arztebl Int. 2014 Mar
21;111(12):213-4. doi: 10.3238/arztebl.2014.0213c. PubMed PMID: 24717310; PubMed
Central PMCID: PMC3983703.


121: Freitag TL, Loponen J, Messing M, Zevallos V, Andersson LC, Sontag-Strohm T,
Saavalainen P, Schuppan D, Salovaara H, Meri S. Testing safety of germinated rye
sourdough in a celiac disease model based on the adoptive transfer of
prolamin-primed memory T cells into lymphopenic mice. Am J Physiol Gastrointest
Liver Physiol. 2014 Mar;306(6):G526-34. doi: 10.1152/ajpgi.00136.2013. Epub 2014
Jan 23. PubMed PMID: 24458020.


122: Schuppan D, Zimmer KP. The diagnosis and treatment of celiac disease. Dtsch
Arztebl Int. 2013 Dec 6;110(49):835-46. doi: 10.3238/arztebl.2013.0835. Review.
PubMed PMID: 24355936; PubMed Central PMCID: PMC3884535.


123: Yoshida S, Kornek M, Ikenaga N, Schmelzle M, Masuzaki R, Csizmadia E, Wu Y,
Robson SC, Schuppan D. Sublethal heat treatment promotes epithelial-mesenchymal
transition and enhances the malignant potential of hepatocellular carcinoma.
Hepatology. 2013 Nov;58(5):1667-80. doi: 10.1002/hep.26526. Epub 2013 Sep 19.
PubMed PMID: 23729316.


124: Lukacs-Kornek V, Schuppan D. Dendritic cells in liver injury and fibrosis:
shortcomings and promises. J Hepatol. 2013 Nov;59(5):1124-6. doi:
10.1016/j.jhep.2013.05.033. Epub 2013 May 29. PubMed PMID: 23727306.


125: Catassi C, Bai JC, Bonaz B, Bouma G, Calabrò A, Carroccio A, Castillejo G,
Ciacci C, Cristofori F, Dolinsek J, Francavilla R, Elli L, Green P, Holtmeier W,
Koehler P, Koletzko S, Meinhold C, Sanders D, Schumann M, Schuppan D, Ullrich R,
Vécsei A, Volta U, Zevallos V, Sapone A, Fasano A. Non-Celiac Gluten sensitivity:
the new frontier of gluten related disorders. Nutrients. 2013 Sep
26;5(10):3839-53. doi: 10.3390/nu5103839. Review. PubMed PMID: 24077239; PubMed
Central PMCID: PMC3820047.


126: Fernandez-Feo M, Wei G, Blumenkranz G, Dewhirst FE, Schuppan D, Oppenheim
FG, Helmerhorst EJ. The cultivable human oral gluten-degrading microbiome and its
potential implications in coeliac disease and gluten sensitivity. Clin Microbiol
Infect. 2013 Sep;19(9):E386-94. doi: 10.1111/1469-0691.12249. Epub 2013 May 28.
PubMed PMID: 23714165; PubMed Central PMCID: PMC3749263.


127: Schuppan D, Schattenberg JM. Non-alcoholic steatohepatitis: pathogenesis and
novel therapeutic approaches. J Gastroenterol Hepatol. 2013 Aug;28 Suppl 1:68-76.
doi: 10.1111/jgh.12212. Review. PubMed PMID: 23855299.


128: Yanagisawa K, Yue S, van der Vliet HJ, Wang R, Alatrakchi N, Golden-Mason L,
Schuppan D, Koziel MJ, Rosen HR, Exley MA. Ex vivo analysis of resident hepatic
pro-inflammatory CD1d-reactive T cells and hepatocyte surface CD1d expression in
hepatitis C. J Viral Hepat. 2013 Aug;20(8):556-65. doi: 10.1111/jvh.12081. Epub
2013 Mar 11. PubMed PMID: 23808994; PubMed Central PMCID: PMC4054599.


129: Kuramitsu K, Sverdlov DY, Liu SB, Csizmadia E, Burkly L, Schuppan D, Hanto
DW, Otterbein LE, Popov Y. Failure of fibrotic liver regeneration in mice is
linked to a severe fibrogenic response driven by hepatic progenitor cell
activation. Am J Pathol. 2013 Jul;183(1):182-94. doi:
10.1016/j.ajpath.2013.03.018. Epub 2013 May 14. PubMed PMID: 23680654; PubMed
Central PMCID: PMC3702745.


130: Leffler D, Schuppan D, Pallav K, Najarian R, Goldsmith JD, Hansen J, Kabbani
T, Dennis M, Kelly CP. Kinetics of the histological, serological and symptomatic
responses to gluten challenge in adults with coeliac disease. Gut. 2013
Jul;62(7):996-1004. doi: 10.1136/gutjnl-2012-302196. Epub 2012 May 22. PubMed
PMID: 22619366; PubMed Central PMCID: PMC3525791.


131: Olinga P, Schuppan D. Precision-cut liver slices: a tool to model the liver
ex vivo. J Hepatol. 2013 Jun;58(6):1252-3. doi: 10.1016/j.jhep.2013.01.009. Epub
2013 Jan 18. PubMed PMID: 23336979.


132: Chowdhury S, Chen Y, Yao TW, Ajami K, Wang XM, Popov Y, Schuppan D,
Bertolino P, McCaughan GW, Yu DM, Gorrell MD. Regulation of dipeptidyl peptidase
8 and 9 expression in activated lymphocytes and injured liver. World J
Gastroenterol. 2013 May 21;19(19):2883-93. doi: 10.3748/wjg.v19.i19.2883. PubMed
PMID: 23704821; PubMed Central PMCID: PMC3660813.


133: Schuppan D, Kim YO. Evolving therapies for liver fibrosis. J Clin Invest.
2013 May;123(5):1887-901. doi: 10.1172/JCI66028. Epub 2013 May 1. Review. PubMed
PMID: 23635787; PubMed Central PMCID: PMC3635731.


134: Berenguer M, Schuppan D. Progression of liver fibrosis in post-transplant
hepatitis C: mechanisms, assessment and treatment. J Hepatol. 2013
May;58(5):1028-41. doi: 10.1016/j.jhep.2012.12.014. Epub 2012 Dec 20. Review.
PubMed PMID: 23262248.


135: Zevallos VF, Schuppan D. Refractory coeliac disease: one step closer to the
origin of aberrant lymphocytes. Gut. 2013 Apr;62(4):485-6. doi:
10.1136/gutjnl-2012-303030. Epub 2012 Sep 1. PubMed PMID: 22942236.


136: Weng SY, Schuppan D. AMPK regulates macrophage polarization in adipose
tissue inflammation and NASH. J Hepatol. 2013 Mar;58(3):619-21. doi:
10.1016/j.jhep.2012.09.031. Epub 2012 Oct 6. PubMed PMID: 23046670.


137: Bai JC, Fried M, Corazza GR, Schuppan D, Farthing M, Catassi C, Greco L,
Cohen H, Ciacci C, Eliakim R, Fasano A, González A, Krabshuis JH, LeMair A; World
Gastroenterology Organization. World Gastroenterology Organisation global
guidelines on celiac disease. J Clin Gastroenterol. 2013 Feb;47(2):121-6. doi:
10.1097/MCG.0b013e31827a6f83. PubMed PMID: 23314668.


138: Schmelzle M, Splith K, Andersen LW, Kornek M, Schuppan D, Jones-Bamman C,
Nowak M, Toxavidis V, Salhanick SD, Han L, Schulte am Esch J, Jonas S, Donnino
MW, Robson SC. Increased plasma levels of microparticles expressing CD39 and
CD133 in acute liver injury. Transplantation. 2013 Jan 15;95(1):63-9. doi:
10.1097/TP.0b013e318278d3cd. PubMed PMID: 23232366; PubMed Central PMCID:
PMC3536489.


139: Kwong GA, von Maltzahn G, Murugappan G, Abudayyeh O, Mo S, Papayannopoulos
IA, Sverdlov DY, Liu SB, Warren AD, Popov Y, Schuppan D, Bhatia SN. Mass-encoded
synthetic biomarkers for multiplexed urinary monitoring of disease. Nat
Biotechnol. 2013 Jan;31(1):63-70. doi: 10.1038/nbt.2464. Epub 2012 Dec 16. PubMed
PMID: 23242163; PubMed Central PMCID: PMC3542405.


140: Junker Y, Zeissig S, Kim SJ, Barisani D, Wieser H, Leffler DA, Zevallos V,
Libermann TA, Dillon S, Freitag TL, Kelly CP, Schuppan D. Wheat amylase trypsin
inhibitors drive intestinal inflammation via activation of toll-like receptor 4.
J Exp Med. 2012 Dec 17;209(13):2395-408. doi: 10.1084/jem.20102660. Epub 2012 Dec
3. PubMed PMID: 23209313; PubMed Central PMCID: PMC3526354.


141: Li S, Vriend LE, Nasser IA, Popov Y, Afdhal NH, Koziel MJ, Schuppan D, Exley
MA, Alatrakchi N. Hepatitis C virus-specific T-cell-derived transforming growth
factor beta is associated with slow hepatic fibrogenesis. Hepatology. 2012
Dec;56(6):2094-105. doi: 10.1002/hep.25951. PubMed PMID: 22806830; PubMed Central
PMCID: PMC3508175.


142: Kornek M, Schuppan D. Microparticles: Modulators and biomarkers of liver
disease. J Hepatol. 2012 Nov;57(5):1144-6. doi: 10.1016/j.jhep.2012.07.029. Epub
2012 Aug 6. PubMed PMID: 22878465.


143: Mukherjee R, Kelly CP, Schuppan D. Nondietary therapies for celiac disease.
Gastrointest Endosc Clin N Am. 2012 Oct;22(4):811-31. doi:
10.1016/j.giec.2012.09.001. Review. PubMed PMID: 23083995.


144: Klempner SJ, Choueiri TK, Yee E, Doyle LA, Schuppan D, Atkins MB. Severe
pazopanib-induced hepatotoxicity: clinical and histologic course in two patients.
J Clin Oncol. 2012 Sep 20;30(27):e264-8. doi: 10.1200/JCO.2011.41.0332. Epub 2012
Jul 16. PubMed PMID: 22802316.


145: Montier Y, Lorentz A, Krämer S, Sellge G, Schock M, Bauer M, Schuppan D,
Bischoff SC. Central role of IL-6 and MMP-1 for cross talk between human
intestinal mast cells and human intestinal fibroblasts. Immunobiology. 2012
Sep;217(9):912-9. doi: 10.1016/j.imbio.2012.01.003. Epub 2012 Jan 4. PubMed PMID:
22356938.


146: Schattenberg JM, Nagel M, Kim YO, Kohl T, Wörns MA, Zimmermann T, Schad A,
Longerich T, Schuppan D, He YW, Galle PR, Schuchmann M. Increased hepatic
fibrosis and JNK2-dependent liver injury in mice exhibiting hepatocyte-specific
deletion of cFLIP. Am J Physiol Gastrointest Liver Physiol. 2012 Aug
15;303(4):G498-506. doi: 10.1152/ajpgi.00525.2011. Epub 2012 Jun 14. PubMed PMID:
22700824.


147: Martin CR, Zaman MM, Ketwaroo GA, Bhutta AQ, Coronel E, Popov Y, Schuppan D,
Freedman SD. CFTR dysfunction predisposes to fibrotic liver disease in a murine
model. Am J Physiol Gastrointest Liver Physiol. 2012 Aug 15;303(4):G474-81. doi:
10.1152/ajpgi.00055.2012. Epub 2012 Jun 7. PubMed PMID: 22679000; PubMed Central
PMCID: PMC3423138.


148: Kornek M, Lynch M, Mehta SH, Lai M, Exley M, Afdhal NH, Schuppan D.
Circulating microparticles as disease-specific biomarkers of severity of
inflammation in patients with hepatitis C or nonalcoholic steatohepatitis.
Gastroenterology. 2012 Aug;143(2):448-58. doi: 10.1053/j.gastro.2012.04.031. Epub
2012 Apr 24. PubMed PMID: 22537612; PubMed Central PMCID: PMC3404266.


149: Pallav K, Leffler DA, Bennett M, Tariq S, Xu H, Kabbani T, Moss AC, Dennis
M, Kelly CP, Schuppan D. Open conformation tissue transglutaminase testing for
celiac dietary assessment. Dig Liver Dis. 2012 May;44(5):375-8. doi:
10.1016/j.dld.2011.12.008. Epub 2012 Jan 18. PubMed PMID: 22261352; PubMed
Central PMCID: PMC3384702.


150: Jürgensen C, Neser F, Boese-Landgraf J, Schuppan D, Stölzel U,
Fritscher-Ravens A. Endoscopic ultrasound-guided endoscopic necrosectomy of the
pancreas: is irrigation necessary? Surg Endosc. 2012 May;26(5):1359-63. doi:
10.1007/s00464-011-2039-9. Epub 2011 Nov 15. PubMed PMID: 22083336.


151: Kim YO, Schuppan D. When GLP-1 hits the liver: a novel approach for insulin
resistance and NASH. Am J Physiol Gastrointest Liver Physiol. 2012 Apr
15;302(8):G759-61. doi: 10.1152/ajpgi.00078.2012. Epub 2012 Mar 1. PubMed PMID:
22383493.


152: Schuppan D, Pinzani M. Anti-fibrotic therapy: lost in translation? J
Hepatol. 2012;56 Suppl 1:S66-74. doi: 10.1016/S0168-8278(12)60008-7. Review.
PubMed PMID: 22300467.


153: Shimada M, Yoshida S, Masuzaki R, Schuppan D. Pitavastatin enhances
antiviral efficacy of standard pegylated interferon plus ribavirin in patients
with chronic hepatitis C: a prospective randomized pilot study. J Hepatol. 2012
Jan;56(1):299-300. doi: 10.1016/j.jhep.2011.04.024. Epub 2011 Jun 28. PubMed
PMID: 21718671.


154: Schattenberg JM, Schuppan D. Nonalcoholic steatohepatitis: the therapeutic
challenge of a global epidemic. Curr Opin Lipidol. 2011 Dec;22(6):479-88. doi:
10.1097/MOL.0b013e32834c7cfc. Review. PubMed PMID: 22002020.


155: Poelstra K, Schuppan D. Targeted therapy of liver fibrosis/cirrhosis and its
complications. J Hepatol. 2011 Sep;55(3):726-728. doi:
10.1016/j.jhep.2011.04.008. Epub 2011 May 8. PubMed PMID: 21601600.


156: Bansal R, Prakash J, Post E, Beljaars L, Schuppan D, Poelstra K. Novel
engineered targeted interferon-gamma blocks hepatic fibrogenesis in mice.
Hepatology. 2011 Aug;54(2):586-96. doi: 10.1002/hep.24395. Epub 2011 Jun 26.
PubMed PMID: 21538439.


157: Seven G, Karatayli SC, Köse SK, Yakut M, Kabaçam G, Törüner M, Heper AO,
Voelker M, Erden E, Bozdayi AM, Uzunalımoğlu O, Bozkaya H, Yurdaydin C, Schuppan
D. Serum connective tissue markers as predictors of advanced fibrosis in patients
with chronic hepatitis B and D. Turk J Gastroenterol. 2011 Jun;22(3):305-14.
PubMed PMID: 21805422.


158: Roshan B, Leffler DA, Jamma S, Dennis M, Sheth S, Falchuk K, Najarian R,
Goldsmith J, Tariq S, Schuppan D, Kelly CP. The incidence and clinical spectrum
of refractory celiac disease in a north american referral center. Am J
Gastroenterol. 2011 May;106(5):923-8. doi: 10.1038/ajg.2011.104. Epub 2011 Apr 5.
PubMed PMID: 21468013.


159: Popov Y, Sverdlov DY, Sharma AK, Bhaskar KR, Li S, Freitag TL, Lee J,
Dieterich W, Melino G, Schuppan D. Tissue transglutaminase does not affect
fibrotic matrix stability or regression of liver fibrosis in mice.
Gastroenterology. 2011 May;140(5):1642-52. doi: 10.1053/j.gastro.2011.01.040.
Epub 2011 Jan 26. PubMed PMID: 21277850; PubMed Central PMCID: PMC3374132.


160: Lin W, Wu G, Li S, Weinberg EM, Kumthip K, Peng LF, Méndez-Navarro J, Chen
WC, Jilg N, Zhao H, Goto K, Zhang L, Brockman MA, Schuppan D, Chung RT. HIV and
HCV cooperatively promote hepatic fibrogenesis via induction of reactive oxygen
species and NFkappaB. J Biol Chem. 2011 Jan 28;286(4):2665-74. doi:
10.1074/jbc.M110.168286. Epub 2010 Nov 22. PubMed PMID: 21098019; PubMed Central
PMCID: PMC3024762.


161: Ruehl M, Muche M, Freise C, Erben U, Neumann U, Schuppan D, Popov Y,
Dieterich W, Zeitz M, Farndale RW, Somasundaram R. Hydroxyproline-containing
collagen analogs trigger the release and activation of collagen-sequestered
proMMP-2 by competition with prodomain-derived peptide P33-42. Fibrogenesis
Tissue Repair. 2011 Jan 6;4(1):1. doi: 10.1186/1755-1536-4-1. PubMed PMID:
21211003; PubMed Central PMCID: PMC3024946.


162: Yedibela S, Demir R, Melling N, Aydin Ü, Schuppan D, Müller V, Hohenberger
W, Schönleben F. Antiviral re-treatment of IFN-ribavirin non-responders for
recurrent post-transplantation hepatitis C. Clin Transplant. 2011
Jan-Feb;25(1):131-5. doi: 10.1111/j.1399-0012.2009.01201.x. PubMed PMID:
20438578.


163: Kornek M, Popov Y, Libermann TA, Afdhal NH, Schuppan D. Human T cell
microparticles circulate in blood of hepatitis patients and induce fibrolytic
activation of hepatic stellate cells. Hepatology. 2011 Jan;53(1):230-42. doi:
10.1002/hep.23999. Epub 2010 Oct 26. PubMed PMID: 20979056; PubMed Central PMCID:
PMC3505073.


164: Jamma S, Leffler DA, Dennis M, Najarian RM, Schuppan DB, Sheth S, Kelly CP.
Small intestinal release mesalamine for the treatment of refractory celiac
disease type I. J Clin Gastroenterol. 2011 Jan;45(1):30-3. doi:
10.1097/MCG.0b013e3181f42401. PubMed PMID: 20871406.


165: Zamakhchari M, Wei G, Dewhirst F, Lee J, Schuppan D, Oppenheim FG,
Helmerhorst EJ. Identification of Rothia bacteria as gluten-degrading natural
colonizers of the upper gastro-intestinal tract. PLoS One. 2011;6(9):e24455. doi:
10.1371/journal.pone.0024455. Epub 2011 Sep 21. PubMed PMID: 21957450; PubMed
Central PMCID: PMC3177827.


166: Leffler DA, Schuppan D. Update on serologic testing in celiac disease. Am J
Gastroenterol. 2010 Dec;105(12):2520-4. doi: 10.1038/ajg.2010.276. Review. PubMed
PMID: 21131921.


167: Urban TJ, Thompson AJ, Bradrick SS, Fellay J, Schuppan D, Cronin KD, Hong L,
McKenzie A, Patel K, Shianna KV, McHutchison JG, Goldstein DB, Afdhal N. IL28B
genotype is associated with differential expression of intrahepatic
interferon-stimulated genes in patients with chronic hepatitis C. Hepatology.
2010 Dec;52(6):1888-96. doi: 10.1002/hep.23912. Epub 2010 Oct 7. PubMed PMID:
20931559; PubMed Central PMCID: PMC3653303.


168: Shimada M, Yoshida S, Kornek M, Kim SJ, Schuppan D. A change of
peginterferon may permit continuation of antiviral therapy in hepatitis C
virus-infected patients with interstitial pneumonitis. Liver Int. 2010
Nov;30(10):1552-4. doi: 10.1111/j.1478-3231.2010.02297.x. PubMed PMID: 20557455.


169: Helmerhorst EJ, Zamakhchari M, Schuppan D, Oppenheim FG. Discovery of a
novel and rich source of gluten-degrading microbial enzymes in the oral cavity.
PLoS One. 2010 Oct 11;5(10):e13264. doi: 10.1371/journal.pone.0013264. PubMed
PMID: 20948997; PubMed Central PMCID: PMC2952584.


170: Malik R, Schuppan D. Serum fibrosis markers to predict clinical and
histological progression in hepatitis C non-responders. Gut. 2010
Oct;59(10):1312-3. doi: 10.1136/gut.2010.219162. PubMed PMID: 20833662.


171: Yoshida S, Shimada M, Kornek M, Kim SJ, Shimada K, Schuppan D. Elevated
transaminases as a predictor of coma in a patient with anorexia nervosa: a case
report and review of the literature. J Med Case Rep. 2010 Sep 17;4:307. doi:
10.1186/1752-1947-4-307. PubMed PMID: 20849624; PubMed Central PMCID: PMC2945359.


172: Popov Y, Schuppan D. Epithelial-to-mesenchymal transition in liver fibrosis:
dead or alive? Gastroenterology. 2010 Sep;139(3):722-5. doi:
10.1053/j.gastro.2010.07.015. Epub 2010 Aug 1. PubMed PMID: 20682361.


173: Malik R, Lai M, Sadiq A, Farnan R, Mehta S, Nasser I, Challies T, Schuppan
D, Afdhal N. Comparison of transient elastography, serum markers and clinical
signs for the diagnosis of compensated cirrhosis. J Gastroenterol Hepatol. 2010
Sep;25(9):1562-8. doi: 10.1111/j.1440-1746.2010.06371.x. PubMed PMID: 20796156.


174: Jamma S, Rubio-Tapia A, Kelly CP, Murray J, Najarian R, Sheth S, Schuppan D,
Dennis M, Leffler DA. Celiac crisis is a rare but serious complication of celiac
disease in adults. Clin Gastroenterol Hepatol. 2010 Jul;8(7):587-90. doi:
10.1016/j.cgh.2010.04.009. Epub 2010 Apr 24. PubMed PMID: 20417725; PubMed
Central PMCID: PMC2900539.


175: Freitag TL, Cham C, Sung HH, Beilhack GF, Durinovic-Belló I, Patel SD,
Bronson RT, Schuppan D, Sønderstrup G. Human risk allele HLA-DRB1*0405
predisposes class II transgenic Ab0 NOD mice to autoimmune pancreatitis.
Gastroenterology. 2010 Jul;139(1):281-91. doi: 10.1053/j.gastro.2010.03.038. Epub
2010 Mar 18. PubMed PMID: 20303356; PubMed Central PMCID: PMC2902648.


176: Schuppan D, Gorrell MD, Klein T, Mark M, Afdhal NH. The challenge of
developing novel pharmacological therapies for non-alcoholic steatohepatitis.
Liver Int. 2010 Jul;30(6):795-808. doi: 10.1111/j.1478-3231.2010.02264.x. Review.
PubMed PMID: 20624207.


177: de Meijer VE, Sverdlov DY, Popov Y, Le HD, Meisel JA, Nosé V, Schuppan D,
Puder M. Broad-spectrum matrix metalloproteinase inhibition curbs inflammation
and liver injury but aggravates experimental liver fibrosis in mice. PLoS One.
2010 Jun 25;5(6):e11256. doi: 10.1371/journal.pone.0011256. PubMed PMID:
20593020; PubMed Central PMCID: PMC2892485.


178: Robson SC, Schuppan D. Adenosine: tipping the balance towards hepatic
steatosis and fibrosis. J Hepatol. 2010 Jun;52(6):941-3. doi:
10.1016/j.jhep.2010.02.009. Epub 2010 Mar 24. PubMed PMID: 20395005; PubMed
Central PMCID: PMC2875264.


179: Popov Y, Sverdlov DY, Bhaskar KR, Sharma AK, Millonig G, Patsenker E,
Krahenbuhl S, Krahenbuhl L, Schuppan D. Macrophage-mediated phagocytosis of
apoptotic cholangiocytes contributes to reversal of experimental biliary
fibrosis. Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G323-34. doi:
10.1152/ajpgi.00394.2009. Epub 2010 Jan 7. PubMed PMID: 20056896; PubMed Central
PMCID: PMC2838516.


180: Ciccocioppo R, Finamore A, Mengheri E, Millimaggi D, Esslinger B, Dieterich
W, Papola F, Colangeli S, Tombolino V, Schuppan D, Corazza GR. Isolation and
characterization of circulating tissue transglutaminase-specific T cells in
coeliac disease. Int J Immunopathol Pharmacol. 2010 Jan-Mar;23(1):179-91. PubMed
PMID: 20377989.


181: Popov Y, Schuppan D. CD8+ T cells drive adipose tissue inflammation--a novel
clue for NASH pathogenesis? J Hepatol. 2010 Jan;52(1):130-2. doi:
10.1016/j.jhep.2009.10.019. Epub 2009 Oct 29. PubMed PMID: 19914729.

 

182: Lohwasser C, Neureiter D, Popov Y, Bauer M, Schuppan D. Role of the receptor
for advanced glycation end products in hepatic fibrosis. World J Gastroenterol.
2009 Dec 14;15(46):5789-98. PubMed PMID: 19998499; PubMed Central PMCID:
PMC2791271.


183: Leffler DA, Dennis M, Edwards George J, Jamma S, Cook EF, Schuppan D, Kelly
CP. A validated disease-specific symptom index for adults with celiac disease.
Clin Gastroenterol Hepatol. 2009 Dec;7(12):1328-34, 1334.e1-3. doi:
10.1016/j.cgh.2009.07.031. Epub 2009 Aug 7. PubMed PMID: 19665584.


184: Schuppan D, Junker Y, Barisani D. Celiac disease: from pathogenesis to novel
therapies. Gastroenterology. 2009 Dec;137(6):1912-33. doi:
10.1053/j.gastro.2009.09.008. Epub 2009 Sep 18. Review. PubMed PMID: 19766641.


185: Freitag TL, Rietdijk S, Junker Y, Popov Y, Bhan AK, Kelly CP, Terhorst C,
Schuppan D. Gliadin-primed CD4+CD45RBlowCD25- T cells drive gluten-dependent
small intestinal damage after adoptive transfer into lymphopenic mice. Gut. 2009
Dec;58(12):1597-605. doi: 10.1136/gut.2009.186361. Epub 2009 Aug 10. PubMed PMID:
19671544; PubMed Central PMCID: PMC3733237.


186: Marietta EV, Schuppan D, Murray JA. In vitro and in vivo models of celiac
disease. Expert Opin Drug Discov. 2009 Nov;4(11):1113-23. doi:
10.1517/17460440903307417. Epub 2009 Oct 6. PubMed PMID: 23480432.


187: Patsenker E, Popov Y, Stickel F, Schneider V, Ledermann M, Sägesser H,
Niedobitek G, Goodman SL, Schuppan D. Pharmacological inhibition of integrin
alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic
angiogenesis. Hepatology. 2009 Nov;50(5):1501-11. doi: 10.1002/hep.23144. PubMed
PMID: 19725105; PubMed Central PMCID: PMC2779730.


188: Schuppan D, Popov Y. Rationale and targets for antifibrotic therapies.
Gastroenterol Clin Biol. 2009 Oct-Nov;33(10-11):949-57. doi:
10.1016/j.gcb.2009.07.021. Epub 2009 Sep 1. Review. PubMed PMID: 19726145.


189: Popov Y, Schuppan D. Targeting liver fibrosis: strategies for development
and validation of antifibrotic therapies. Hepatology. 2009 Oct;50(4):1294-306.
doi: 10.1002/hep.23123. Review. PubMed PMID: 19711424.


190: Elli L, Bergamini CM, Bardella MT, Schuppan D. Transglutaminases in
inflammation and fibrosis of the gastrointestinal tract and the liver. Dig Liver
Dis. 2009 Aug;41(8):541-50. doi: 10.1016/j.dld.2008.12.095. Epub 2009 Feb 4.
Review. PubMed PMID: 19195940.


191: Leffler DA, Dennis M, Edwards George JB, Jamma S, Magge S, Cook EF, Schuppan
D, Kelly CP. A simple validated gluten-free diet adherence survey for adults with
celiac disease. Clin Gastroenterol Hepatol. 2009 May;7(5):530-6, 536.e1-2. doi:
10.1016/j.cgh.2008.12.032. Epub 2009 Jan 11. PubMed PMID: 19268725.


192: Garud S, Leffler D, Dennis M, Edwards-George J, Saryan D, Sheth S, Schuppan
D, Jamma S, Kelly CP. Interaction between psychiatric and autoimmune disorders in
coeliac disease patients in the Northeastern United States. Aliment Pharmacol
Ther. 2009 Apr 15;29(8):898-905. doi: 10.1111/j.1365-2036.2009.03942.x. PubMed
PMID: 19183153; PubMed Central PMCID: PMC2763921.


193: Malik R, Chang M, Bhaskar K, Nasser I, Curry M, Schuppan D, Byrnes V, Afdhal
N. The clinical utility of biomarkers and the nonalcoholic steatohepatitis CRN
liver biopsy scoring system in patients with nonalcoholic fatty liver disease. J
Gastroenterol Hepatol. 2009 Apr;24(4):564-8. PubMed PMID: 19378390.


194: Millonig G, Hegedüsch S, Becker L, Seitz HK, Schuppan D, Mueller S.
Hypoxia-inducible factor 1 alpha under rapid enzymatic hypoxia: cells sense
decrements of oxygen but not hypoxia per se. Free Radic Biol Med. 2009 Jan
15;46(2):182-91. doi: 10.1016/j.freeradbiomed.2008.09.043. Epub 2008 Nov 1.
PubMed PMID: 19007879.


195: Rakhimova M, Esslinger B, Schulze-Krebs A, Hahn EG, Schuppan D, Dieterich W.
In vitro differentiation of human monocytes into dendritic cells by
peptic-tryptic digest of gliadin is independent of genetic predisposition and the
presence of celiac disease. J Clin Immunol. 2009 Jan;29(1):29-37. doi:
10.1007/s10875-008-9228-x. Epub 2008 Aug 12. PubMed PMID: 18696220.


196: Hopfner M, Schuppan D, Scherubl H. Targeted medical therapy of biliary tract
cancer: recent advances and future perspectives. World J Gastroenterol. 2008 Dec
14;14(46):7021-32. Review. PubMed PMID: 19084910; PubMed Central PMCID:
PMC2776833.


197: Omenetti A, Porrello A, Jung Y, Yang L, Popov Y, Choi SS, Witek RP, Alpini
G, Venter J, Vandongen HM, Syn WK, Baroni GS, Benedetti A, Schuppan D, Diehl AM.
Hedgehog signaling regulates epithelial-mesenchymal transition during biliary
fibrosis in rodents and humans. J Clin Invest. 2008 Oct;118(10):3331-42. doi:
10.1172/JCI35875. PubMed PMID: 18802480; PubMed Central PMCID: PMC2542850.


198: Omenetti A, Popov Y, Jung Y, Choi SS, Witek RP, Yang L, Brown KD, Schuppan
D, Diehl AM. The hedgehog pathway regulates remodelling responses to biliary
obstruction in rats. Gut. 2008 Sep;57(9):1275-82. doi: 10.1136/gut.2008.148619.
Epub 2008 Mar 28. PubMed PMID: 18375471.


199: Patsenker E, Popov Y, Stickel F, Jonczyk A, Goodman SL, Schuppan D.
Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth
factor-beta activation and retards biliary fibrosis progression.
Gastroenterology. 2008 Aug;135(2):660-70. doi: 10.1053/j.gastro.2008.04.009. Epub
2008 Apr 16. PubMed PMID: 18538673; PubMed Central PMCID: PMC3505071.


200: Stickel F, Osterreicher CH, Halangk J, Berg T, Homann N, Hellerbrand C,
Patsenker E, Schneider V, Kolb A, Friess H, Schuppan D, Puhl G, Seitz HK,
Leathart JL, Day CP. No role of matrixmetalloproteinase-3 genetic promoter
polymorphism 1171 as a risk factor for cirrhosis in alcoholic liver disease.
Alcohol Clin Exp Res. 2008 Jun;32(6):959-65. doi:
10.1111/j.1530-0277.2008.00654.x. Epub 2008 Apr 26. PubMed PMID: 18445105.

201: Leffler DA, Edwards-George J, Dennis M, Schuppan D, Cook F, Franko DL,
Blom-Hoffman J, Kelly CP. Factors that influence adherence to a gluten-free diet
in adults with celiac disease. Dig Dis Sci. 2008 Jun;53(6):1573-81. PubMed PMID:
17990115; PubMed Central PMCID: PMC3756800.


202: Höpfner M, Schuppan D, Scherübl H. Treatment of gastrointestinal
neuroendocrine tumors with inhibitors of growth factor receptors and their
signaling pathways: recent advances and future perspectives. World J
Gastroenterol. 2008 Apr 28;14(16):2461-73. Review. PubMed PMID: 18442192; PubMed
Central PMCID: PMC2708356.


203: Schuppan D, Afdhal NH. Liver cirrhosis. Lancet. 2008 Mar 8;371(9615):838-51.
doi: 10.1016/S0140-6736(08)60383-9. Review. PubMed PMID: 18328931; PubMed Central
PMCID: PMC2271178.


204: Popov Y, Patsenker E, Stickel F, Zaks J, Bhaskar KR, Niedobitek G, Kolb A,
Friess H, Schuppan D. Integrin alphavbeta6 is a marker of the progression of
biliary and portal liver fibrosis and a novel target for antifibrotic therapies.
J Hepatol. 2008 Mar;48(3):453-64. doi: 10.1016/j.jhep.2007.11.021. Epub 2008 Jan
14. PubMed PMID: 18221819.


205: Schuppan D, Kelly CP. Is duodenal biopsy required in all patients with
suspected celiac disease? Nat Clin Pract Gastroenterol Hepatol. 2008
Feb;5(2):70-1. Epub 2007 Nov 27. PubMed PMID: 18043590.


206: Höpfner M, Schuppan D, Scherübl H. Growth factor receptors and related
signalling pathways as targets for novel treatment strategies of hepatocellular
cancer. World J Gastroenterol. 2008 Jan 7;14(1):1-14. Review. PubMed PMID:
18176955; PubMed Central PMCID: PMC2673371.


207: Künzli BM, Nuhn P, Enjyoji K, Banz Y, Smith RN, Csizmadia E, Schuppan D,
Berberat PO, Friess H, Robson SC. Disordered pancreatic inflammatory responses
and inhibition of fibrosis in CD39-null mice. Gastroenterology. 2008
Jan;134(1):292-305. Epub 2007 Oct 25. PubMed PMID: 18036594; PubMed Central
PMCID: PMC2189558.


208: Leffler DA, Edwards George JB, Dennis M, Cook EF, Schuppan D, Kelly CP. A
prospective comparative study of five measures of gluten-free diet adherence in
adults with coeliac disease. Aliment Pharmacol Ther. 2007 Nov 1;26(9):1227-35.
PubMed PMID: 17944737.


209: Dieterich W, Schuppan D. Is gliadin harmful from the first morsel? Dig Liver
Dis. 2007 Oct;39(10):917-21. Epub 2007 Aug 27. Review. PubMed PMID: 17720638.


210: Baradari V, Höpfner M, Huether A, Schuppan D, Scherübl H. Histone
deacetylase inhibitor MS-275 alone or combined with bortezomib or sorafenib
exhibits strong antiproliferative action in human cholangiocarcinoma cells. World
J Gastroenterol. 2007 Sep 7;13(33):4458-66. PubMed PMID: 17724801; PubMed Central
PMCID: PMC4611578.


211: Schuppan D, Junker Y. Turning swords into plowshares: transglutaminase to
detoxify gluten. Gastroenterology. 2007 Sep;133(3):1025-8. PubMed PMID: 17854603.


212: Huether A, Höpfner M, Baradari V, Schuppan D, Scherübl H. Sorafenib alone or
as combination therapy for growth control of cholangiocarcinoma. Biochem
Pharmacol. 2007 May 1;73(9):1308-17. Epub 2007 Jan 5. PubMed PMID: 17266941.


213: Patsenker E, Popov Y, Wiesner M, Goodman SL, Schuppan D. Pharmacological
inhibition of the vitronectin receptor abrogates PDGF-BB-induced hepatic stellate
cell migration and activation in vitro. J Hepatol. 2007 May;46(5):878-87. Epub
2006 Dec 12. PubMed PMID: 17258347.


214: Leffler DA, Dennis M, Hyett B, Kelly E, Schuppan D, Kelly CP. Etiologies and
predictors of diagnosis in nonresponsive celiac disease. Clin Gastroenterol
Hepatol. 2007 Apr;5(4):445-50. Epub 2007 Mar 26. PubMed PMID: 17382600.


215: Stickel F, Schuppan D. Herbal medicine in the treatment of liver diseases.
Dig Liver Dis. 2007 Apr;39(4):293-304. Epub 2007 Feb 28. Review. PubMed PMID:
17331820.


216: Rost D, Welker A, Welker J, Millonig G, Berger I, Autschbach F, Schuppan D,
Mueller S. Liver-homing of purified glucose oxidase: a novel in vivo model of
physiological hepatic oxidative stress (H2O2). J Hepatol. 2007 Mar;46(3):482-91.
Epub 2006 Nov 17. PubMed PMID: 17188390.


217: Isbert C, Ritz JP, Roggan A, Schuppan D, Ajubi N, Buhr HJ, Hohenberger W,
Germer CT. Laser-induced thermotherapy (LITT) elevates mRNA expression of
connective tissue growth factor (CTGF) associated with reduced tumor growth of
liver metastases compared to hepatic resection. Lasers Surg Med. 2007
Jan;39(1):42-50. PubMed PMID: 17111416.


218: Baradari V, Huether A, Höpfner M, Schuppan D, Scherübl H. Antiproliferative
and proapoptotic effects of histone deacetylase inhibitors on gastrointestinal
neuroendocrine tumor cells. Endocr Relat Cancer. 2006 Dec;13(4):1237-50. PubMed
PMID: 17158768.


219: Koda M, Bauer M, Krebs A, Hahn EG, Schuppan D, Murawaki Y. Endothelin-1
enhances fibrogenic gene expression, but does not promote DNA synthesis or
apoptosis in hepatic stellate cells. Comp Hepatol. 2006 Oct 24;5:5. PubMed PMID:
17062135; PubMed Central PMCID: PMC1635728.


220: Daum S, Foss HD, Schuppan D, Riecken EO, Zeitz M, Ullrich R. Synthesis of
collagen I in collagenous sprue. Clin Gastroenterol Hepatol. 2006
Oct;4(10):1232-6. Epub 2006 Sep 18. PubMed PMID: 16979955.


221: Joos S, Wildau N, Kohnen R, Szecsenyi J, Schuppan D, Willich SN, Hahn EG,
Brinkhaus B. Acupuncture and moxibustion in the treatment of ulcerative colitis:
a randomized controlled study. Scand J Gastroenterol. 2006 Sep;41(9):1056-63.
PubMed PMID: 16938719.


222: Huether A, Hopfner M, Sutter AP, Baradari V, Schuppan D, Scherubl H.
Signaling pathways involved in the inhibition of epidermal growth factor receptor
by erlotinib in hepatocellular cancer. World J Gastroenterol. 2006 Aug
28;12(32):5160-7. PubMed PMID: 16937526; PubMed Central PMCID: PMC4088013.


223: Schurr R, Stölzel U, Schuppan D, Schwertner C, Steinberg J, Scherübl H.
[Increased incidence of hepatocellular and intrahepatic cholangiocellular
carcinoma in northeast Germany]. Dtsch Med Wochenschr. 2006 Jul
28;131(30):1649-55. German. PubMed PMID: 16850381.


224: Schuppan D, Kelly CP, Krauss N. Monitoring non-responsive patients with
celiac disease. Gastrointest Endosc Clin N Am. 2006 Jul;16(3):593-603. Review.
PubMed PMID: 16876729.


225: Hansler J, Wissniowski TT, Schuppan D, Witte A, Bernatik T, Hahn EG, Strobel
D. Activation and dramatically increased cytolytic activity of tumor specific T
lymphocytes after radio-frequency ablation in patients with hepatocellular
carcinoma and colorectal liver metastases. World J Gastroenterol. 2006 Jun
21;12(23):3716-21. PubMed PMID: 16773688; PubMed Central PMCID: PMC4087464.


226: Lebensztejn DM, Sobaniec-Lotowska ME, Kaczmarski M, Voelker M, Schuppan D.
Matrix-derived serum markers in monitoring liver fibrosis in children with
chronic hepatitis B treated with interferon alpha. World J Gastroenterol. 2006
Jun 7;12(21):3338-43. PubMed PMID: 16733849; PubMed Central PMCID: PMC4087863.


227: Popov Y, Patsenker E, Bauer M, Niedobitek E, Schulze-Krebs A, Schuppan D.
Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via
activation of p38 and NFkappaB. J Biol Chem. 2006 Jun 2;281(22):15090-8. Epub
2006 Feb 17. PubMed PMID: 16489207.


228: Mueller S, Afdhal NH, Schuppan D. Iron, HCV, and liver cancer: hard metal
setting the pace? Gastroenterology. 2006 Jun;130(7):2229-34. PubMed PMID:
16762645.


229: Jürgensen C, Schuppan D, Neser F, Ernstberger J, Junghans U, Stölzel U.
EUS-guided alcohol ablation of an insulinoma. Gastrointest Endosc. 2006
Jun;63(7):1059-62. PubMed PMID: 16733126.


230: Strnad P, Lienau TC, Tao GZ, Lazzeroni LC, Stickel F, Schuppan D, Omary MB.
Keratin variants associate with progression of fibrosis during chronic hepatitis
C infection. Hepatology. 2006 Jun;43(6):1354-63. PubMed PMID: 16729313.


231: Höpfner M, Huether A, Sutter AP, Baradari V, Schuppan D, Scherübl H.
Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in
hepatocellular carcinoma cells. Biochem Pharmacol. 2006 May 14;71(10):1435-48.
Epub 2006 Mar 10. PubMed PMID: 16530734.


232: Homann N, Stickel F, König IR, Jacobs A, Junghanns K, Benesova M, Schuppan
D, Himsel S, Zuber-Jerger I, Hellerbrand C, Ludwig D, Caselmann WH, Seitz HK.
Alcohol dehydrogenase 1C*1 allele is a genetic marker for alcohol-associated
cancer in heavy drinkers. Int J Cancer. 2006 Apr 15;118(8):1998-2002. PubMed
PMID: 16287084.


233: Krauss N, Schuppan D. Monitoring nonresponsive patients who have celiac
disease. Gastrointest Endosc Clin N Am. 2006 Apr;16(2):317-27. Review. Erratum
in: Gastrointest Endosc Clin N Am. 2006 Jul;16(3):xi. PubMed PMID: 16644460.


234: Dieterich W, Esslinger B, Trapp D, Hahn E, Huff T, Seilmeier W, Wieser H,
Schuppan D. Cross linking to tissue transglutaminase and collagen favours gliadin
toxicity in coeliac disease. Gut. 2006 Apr;55(4):478-84. Epub 2005 Sep 27. PubMed
PMID: 16188922; PubMed Central PMCID: PMC1856150.


235: Teubner A, Richter M, Schuppan D, Köstler E, Stölzel U. [Hepatitis C,
hemochromatosis and porphyria cutanea tarda]. Dtsch Med Wochenschr. 2006 Mar
31;131(13):691-5. Review. German. PubMed PMID: 16555178.


236: Pavel ME, Hoppe S, Papadopoulos T, Linder V, Mohr B, Hahn EG, Lohmann T,
Schuppan D. Adrenomedullin is a novel marker of tumor progression in
neuroendocrine carcinomas. Horm Metab Res. 2006 Feb;38(2):112-8. PubMed PMID:
16523412.


237: Lohwasser C, Neureiter D, Weigle B, Kirchner T, Schuppan D. The receptor for
advanced glycation end products is highly expressed in the skin and upregulated
by advanced glycation end products and tumor necrosis factor-alpha. J Invest
Dermatol. 2006 Feb;126(2):291-9. PubMed PMID: 16374460.


238: Metzger MH, Heier M, Mäki M, Bravi E, Schneider A, Löwel H, Illig T,
Schuppan D, Wichmann HE. Mortality excess in individuals with elevated IgA
anti-transglutaminase antibodies: the KORA/MONICA Augsburg cohort study
1989-1998. Eur J Epidemiol. 2006;21(5):359-65. Epub 2006 Apr 29. PubMed PMID:
16649072.


239: Pavel ME, Baum U, Hahn EG, Schuppan D, Lohmann T. Efficacy and tolerability
of pegylated IFN-alpha in patients with neuroendocrine gastroenteropancreatic
carcinomas. J Interferon Cytokine Res. 2006 Jan;26(1):8-13. PubMed PMID:
16426143.


240: Konturek PC, Bazela K, Kukharskyy V, Bauer M, Hahn EG, Schuppan D.
Helicobacter pylori upregulates prion protein expression in gastric mucosa: a
possible link to prion disease. World J Gastroenterol. 2005 Dec 28;11(48):7651-6.
PubMed PMID: 16437693; PubMed Central PMCID: PMC4727223.


241: Popov Y, Patsenker E, Fickert P, Trauner M, Schuppan D. Mdr2 (Abcb4)-/- mice
spontaneously develop severe biliary fibrosis via massive dysregulation of pro-
and antifibrogenic genes. J Hepatol. 2005 Dec;43(6):1045-54. Epub 2005 Aug 15.
PubMed PMID: 16223543.


242: Huether A, Höpfner M, Baradari V, Schuppan D, Scherübl H. EGFR blockade by
cetuximab alone or as combination therapy for growth control of hepatocellular
cancer. Biochem Pharmacol. 2005 Nov 25;70(11):1568-78. Epub 2005 Oct 13. PubMed
PMID: 16226226.


243: Ruehl M, Erben U, Schuppan D, Wagner C, Zeller A, Freise C, Al-Hasani H,
Loesekann M, Notter M, Wittig BM, Zeitz M, Dieterich W, Somasundaram R. The
elongated first fibronectin type III domain of collagen XIV is an inducer of
quiescence and differentiation in fibroblasts and preadipocytes. J Biol Chem.
2005 Nov 18;280(46):38537-43. Epub 2005 Aug 29. PubMed PMID: 16129687.


244: Benten D, Kumaran V, Joseph B, Schattenberg J, Popov Y, Schuppan D, Gupta S.
Hepatocyte transplantation activates hepatic stellate cells with beneficial
modulation of cell engraftment in the rat. Hepatology. 2005 Nov;42(5):1072-81.
PubMed PMID: 16250034.


245: Stickel F, Patsenker E, Schuppan D. Herbal hepatotoxicity. J Hepatol. 2005
Nov;43(5):901-10. Epub 2005 Aug 25. Review. PubMed PMID: 16171893.


246: Sutter AP, Maaser K, Höpfner M, Huether A, Schuppan D, Scherübl H. Cell
cycle arrest and apoptosis induction in hepatocellular carcinoma cells by HMG-CoA
reductase inhibitors. Synergistic antiproliferative action with ligands of the
peripheral benzodiazepine receptor. J Hepatol. 2005 Nov;43(5):808-16. Epub 2005
May 31. PubMed PMID: 16083991.


247: Huether A, Höpfner M, Sutter AP, Schuppan D, Scherübl H. Erlotinib induces
cell cycle arrest and apoptosis in hepatocellular cancer cells and enhances
chemosensitivity towards cytostatics. J Hepatol. 2005 Oct;43(4):661-9. PubMed
PMID: 16023762.


248: Stickel F, Osterreicher CH, Datz C, Ferenci P, Wölfel M, Norgauer W, Kraus
MR, Wrba F, Hellerbrand C, Schuppan D. Prediction of progression to cirrhosis by
a glutathione S-transferase P1 polymorphism in subjects with hereditary
hemochromatosis. Arch Intern Med. 2005 Sep 12;165(16):1835-40. PubMed PMID:
16157826.


249: Li ZD, Bork JP, Krueger B, Patsenker E, Schulze-Krebs A, Hahn EG, Schuppan
D. VEGF induces proliferation, migration, and TGF-beta1 expression in mouse
glomerular endothelial cells via mitogen-activated protein kinase and
phosphatidylinositol 3-kinase. Biochem Biophys Res Commun. 2005 Sep
9;334(4):1049-60. PubMed PMID: 16039615.


250: Ocker M, Neureiter D, Lueders M, Zopf S, Ganslmayer M, Hahn EG, Herold C,
Schuppan D. Variants of bcl-2 specific siRNA for silencing antiapoptotic bcl-2 in
pancreatic cancer. Gut. 2005 Sep;54(9):1298-308. PubMed PMID: 16099798; PubMed
Central PMCID: PMC1774673.


251: Reis RC, Schuppan D, Barreto AC, Bauer M, Bork JP, Hassler G, Coelho-Sampaio
T. Endostatin competes with bFGF for binding to heparin-like glycosaminoglycans.
Biochem Biophys Res Commun. 2005 Aug 5;333(3):976-83. PubMed PMID: 15985216.


252: Lebensztejn DM, Sobaniec-Łotowska ME, Bauer M, Kaczmarski M, Voelker M,
Schuppan D. Serum fibrosis markers as predictors of an antifibrotic effect of
interferon alfa in children with chronic hepatitis B. Eur J Gastroenterol
Hepatol. 2005 Aug;17(8):843-8. PubMed PMID: 16003134.


253: Yedibela S, Schuppan D, Müller V, Schellerer V, Tannapfel A, Hohenberger W,
Meyer T. Successful treatment of hepatitis C reinfection with interferon-alpha2b
and ribavirin after liver transplantation. Liver Int. 2005 Aug;25(4):717-22.
PubMed PMID: 15998420.


254: Osterreicher CH, Datz C, Stickel F, Hellerbrand C, Penz M, Hofer H, Wrba F,
Penner E, Schuppan D, Ferenci P. TGF-beta1 codon 25 gene polymorphism is
associated with cirrhosis in patients with hereditary hemochromatosis. Cytokine.
2005 Jul 21;31(2):142-8. PubMed PMID: 15941661.


255: Schulze-Krebs A, Preimel D, Popov Y, Bartenschlager R, Lohmann V, Pinzani M,
Schuppan D. Hepatitis C virus-replicating hepatocytes induce fibrogenic
activation of hepatic stellate cells. Gastroenterology. 2005 Jul;129(1):246-58.
PubMed PMID: 16012951.


256: Koning F, Schuppan D, Cerf-Bensussan N, Sollid LM. Pathomechanisms in celiac
disease. Best Pract Res Clin Gastroenterol. 2005 Jun;19(3):373-87. Review. PubMed
PMID: 15925843.


257: Ocker M, Alajati A, Ganslmayer M, Zopf S, Lüders M, Neureiter D, Hahn EG,
Schuppan D, Herold C. The histone-deacetylase inhibitor SAHA potentiates
proapoptotic effects of 5-fluorouracil and irinotecan in hepatoma cells. J Cancer
Res Clin Oncol. 2005 Jun;131(6):385-94. Epub 2005 Mar 8. PubMed PMID: 15754201.


258: Osterreicher CH, Datz C, Stickel F, Hellerbrand C, Penz M, Hofer H, Wrba F,
Penner E, Schuppan D, Ferenci P. Association of myeloperoxidase promotor
polymorphism with cirrhosis in patients with hereditary hemochromatosis. J
Hepatol. 2005 Jun;42(6):914-9. Epub 2005 Apr 2. PubMed PMID: 15885363.


259: Dan Z, Popov Y, Patsenker E, Preimel D, Liu C, Wang XD, Seitz HK, Schuppan
D, Stickel F. Hepatotoxicity of alcohol-induced polar retinol metabolites
involves apoptosis via loss of mitochondrial membrane potential. FASEB J. 2005
May;19(7):845-7. Epub 2005 Feb 24. PubMed PMID: 15731294.


260: Ganslmayer M, Ocker M, Zopf S, Schuppan D, Hahn EG, Herold C. Hepatocellular
carcinomas do not compromise quantitative tests of liver function.
Hepatogastroenterology. 2005 May-Jun;52(63):881-4. PubMed PMID: 15966225.


261: Pavel ME, Hassler G, Baum U, Hahn EG, Lohmann T, Schuppan D. Circulating
levels of angiogenic cytokines can predict tumour progression and prognosis in
neuroendocrine carcinomas. Clin Endocrinol (Oxf). 2005 Apr;62(4):434-43. PubMed
PMID: 15807874.


262: Graepler F, Verbeek B, Graeter T, Smirnow I, Kong HL, Schuppan D, Bauer M,
Vonthein R, Gregor M, Lauer UM. Combined endostatin/sFlt-1 antiangiogenic gene
therapy is highly effective in a rat model of HCC. Hepatology. 2005
Apr;41(4):879-86. PubMed PMID: 15739185.


263: Schuppan D, Dennis MD, Kelly CP. Celiac disease: epidemiology, pathogenesis,
diagnosis, and nutritional management. Nutr Clin Care. 2005 Apr-Jun;8(2):54-69.
Review. PubMed PMID: 16013224.


264: von Moers A, Zwirner A, Reinhold A, Brückmann O, van Landeghem F,
Stoltenburg-Didinger G, Schuppan D, Herbst H, Schuelke M. Increased mRNA
expression of tissue inhibitors of metalloproteinase-1 and -2 in Duchenne
muscular dystrophy. Acta Neuropathol. 2005 Mar;109(3):285-93. Epub 2004 Dec 23.
PubMed PMID: 15616792.


265: Ciccocioppo R, Di Sabatino A, Bauer M, Della Riccia DN, Bizzini F, Biagi F,
Cifone MG, Corazza GR, Schuppan D. Matrix metalloproteinase pattern in celiac
duodenal mucosa. Lab Invest. 2005 Mar;85(3):397-407. PubMed PMID: 15608660.


266: Rosenberg WM, Voelker M, Thiel R, Becka M, Burt A, Schuppan D, Hubscher S,
Roskams T, Pinzani M, Arthur MJ; European Liver Fibrosis Group. Serum markers
detect the presence of liver fibrosis: a cohort study. Gastroenterology. 2004
Dec;127(6):1704-13. PubMed PMID: 15578508.


267: Höpfner M, Sutter AP, Huether A, Schuppan D, Zeitz M, Scherübl H. Targeting
the epidermal growth factor receptor by gefitinib for treatment of hepatocellular
carcinoma. J Hepatol. 2004 Dec;41(6):1008-16. PubMed PMID: 15582135.


268: Sutter AP, Maaser K, Grabowski P, Bradacs G, Vormbrock K, Höpfner M, Krahn
A, Heine B, Stein H, Somasundaram R, Schuppan D, Zeitz M, Scherübl H. Peripheral
benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human
hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel,
docetaxel, doxorubicin and the Bcl-2 inhibitor HA14-1. J Hepatol. 2004
Nov;41(5):799-807. PubMed PMID: 15519653.


269: Freitag T, Schuppan D. Screening for coeliac disease antigen source and
performance of the anti-tissue transglutaminase ELISA. Dig Liver Dis. 2004
Oct;36(10):658-60. PubMed PMID: 15506663.


270: Stölzel U, Teubner A, Ernstberger J, Habeck JO, Schuppan D. Isolated
elevation of gGT: what should be the diagnostic approach? Dtsch Med Wochenschr.
2004 Sep 3;129 Suppl 2:S54-6. PubMed PMID: 15368168.


271: Brinkhaus B, Hummelsberger J, Kohnen R, Seufert J, Hempen CH, Leonhardy H,
Nögel R, Joos S, Hahn E, Schuppan D. Acupuncture and Chinese herbal medicine in
the treatment of patients with seasonal allergic rhinitis: a
randomized-controlled clinical trial. Allergy. 2004 Sep;59(9):953-60. PubMed
PMID: 15291903.


272: Cramer T, Schuppan D, Bauer M, Pfander D, Neuhaus P, Herbst H. Hepatocyte
growth factor and c-Met expression in rat and human liver fibrosis. Liver Int.
2004 Aug;24(4):335-44. PubMed PMID: 15287857.


273: Ganslmayer M, Ocker M, Kraemer G, Zopf S, Hahn EG, Schuppan D, Herold C. The
combination of tamoxifen and 9cis retinoic acid exerts overadditive anti-tumoral
efficacy in rat hepatocellular carcinoma. J Hepatol. 2004 Jun;40(6):952-6. PubMed
PMID: 15158335.


274: Ocker M, Herold C, Ganslmayer M, Zopf S, Hahn EG, Schuppan D. Potentiated
anticancer effects on hepatoma cells by the retinoid adapalene. Cancer Lett. 2004
May 10;208(1):51-8. PubMed PMID: 15105045.


275: Schuppan D, Freitag T. Fistulising Crohn's disease: MMPs gone awry. Gut.
2004 May;53(5):622-4. Review. PubMed PMID: 15082575; PubMed Central PMCID:
PMC1774058.


276: Ganslmayer M, Ocker M, Zopf S, Leitner S, Hahn EG, Schuppan D, Herold C. A
quadruple therapy synergistically blocks proliferation and promotes apoptosis of
hepatoma cells. Oncol Rep. 2004 May;11(5):943-50. PubMed PMID: 15069530.


277: Lebensztejn DM, Kaczmarski M, Sobaniec-Łotowska M, Bauer M, Voelker M,
Schuppan D. Serum laminin-2 and hyaluronan predict severe liver fibrosis in
children with chronic hepatitis B. Hepatology. 2004 Mar;39(3):868-9. PubMed PMID:
14999715.


278: Freitag T, Schulze-Koops H, Niedobitek G, Melino G, Schuppan D. The role of
the immune response against tissue transglutaminase in the pathogenesis of
coeliac disease. Autoimmun Rev. 2004 Feb;3(2):13-20. Review. PubMed PMID:
15003183.


279: Calabrò A, Grappone C, Pellegrini G, Evangelista S, Tramontana M, Schuppan
D, Herbst H, Milani S. Spatial and temporal pattern of expression of interstitial
collagenase, stromelysin/transin, gelatinase A, and TIMP-1 during experimental
gastric ulcer healing. Digestion. 2004;70(2):127-38. Epub 2004 Sep 16. PubMed
PMID: 15375341.


280: Joos S, Brinkhaus B, Maluche C, Maupai N, Kohnen R, Kraehmer N, Hahn EG,
Schuppan D. Acupuncture and moxibustion in the treatment of active Crohn's
disease: a randomized controlled study. Digestion. 2004;69(3):131-9. Epub 2004
Apr 26. PubMed PMID: 15114043.


281: Hellemans K, Verbuyst P, Quartier E, Schuit F, Rombouts K, Chandraratna RA,
Schuppan D, Geerts A. Differential modulation of rat hepatic stellate phenotype
by natural and synthetic retinoids. Hepatology. 2004 Jan;39(1):97-108. PubMed
PMID: 14752828.


282: Sellge G, Lorentz A, Gebhardt T, Levi-Schaffer F, Bektas H, Manns MP,
Schuppan D, Bischoff SC. Human intestinal fibroblasts prevent apoptosis in human
intestinal mast cells by a mechanism independent of stem cell factor, IL-3, IL-4,
and nerve growth factor. J Immunol. 2004 Jan 1;172(1):260-7. PubMed PMID:
14688333.


283: Isbert C, Ritz JP, Roggan A, Schuppan D, Rühl M, Buhr HJ, Germer CT.
Enhancement of the immune response to residual intrahepatic tumor tissue by
laser-induced thermotherapy (LITT) compared to hepatic resection. Lasers Surg
Med. 2004;35(4):284-92. PubMed PMID: 15493028.


284: Ocker M, Herold C, Ganslmayer M, Hahn EG, Schuppan D. The synthetic retinoid
adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells
in vitro. Int J Cancer. 2003 Nov 10;107(3):453-9. PubMed PMID: 14506747.


285: Dieterich W, Trapp D, Esslinger B, Leidenberger M, Piper J, Hahn E, Schuppan
D. Autoantibodies of patients with coeliac disease are insufficient to block
tissue transglutaminase activity. Gut. 2003 Nov;52(11):1562-6. PubMed PMID:
14570723; PubMed Central PMCID: PMC1773855.


286: Wissniowski TT, Hänsler J, Neureiter D, Frieser M, Schaber S, Esslinger B,
Voll R, Strobel D, Hahn EG, Schuppan D. Activation of tumor-specific T
lymphocytes by radio-frequency ablation of the VX2 hepatoma in rabbits. Cancer
Res. 2003 Oct 1;63(19):6496-500. Erratum in: Cancer Res. 2003 Nov 1;63(21):7543.
Wissniowski, Thadäus Till [corrected to Wissniowski, Thaddäus Till]; Hünsler,
Johannes [corrected to Hänsler, Johannes]. PubMed PMID: 14559842.


287: Dieterich W, Esslinger B, Schuppan D. Pathomechanisms in celiac disease. Int
Arch Allergy Immunol. 2003 Oct;132(2):98-108. Review. PubMed PMID: 14600421.


288: Stickel F, Poeschl G, Schuppan D, Conradt C, Strenge-Hesse A, Fuchs FS,
Hofmann WJ, Seitz HK. Serum hyaluronate correlates with histological progression
in alcoholic liver disease. Eur J Gastroenterol Hepatol. 2003 Sep;15(9):945-50.
PubMed PMID: 12923365.


289: Herold C, Ganslmayer M, Ocker M, Blauberger S, Zopf S, Hahn EG, Schuppan D.
Overadditive anti-proliferative and pro-apoptotic effects of a combination
therapy on colorectal carcinoma cells. Int J Oncol. 2003 Sep;23(3):751-6. PubMed
PMID: 12888913.


290: Stickel F, Hoehn B, Schuppan D, Seitz HK. Review article: Nutritional
therapy in alcoholic liver disease. Aliment Pharmacol Ther. 2003 Aug
15;18(4):357-73. Review. PubMed PMID: 12940921.


291: Schuppan D, Ocker M. Integrin-mediated control of cell growth. Hepatology.
2003 Aug;38(2):289-91. Review. PubMed PMID: 12883471.


292: Pender SL, Braegger C, Gunther U, Monteleone G, Meuli M, Schuppan D,
Macdonald TT. Matrix metalloproteinases in necrotising enterocolitis. Pediatr
Res. 2003 Aug;54(2):160-4. Epub 2003 May 7. PubMed PMID: 12736398.


293: Stickel F, Seitz HK, Schuppan D. [Review "Kava, kavapyrones and toxic liver
injury" by R Teschke, Hanau Zeitschrift für Gastroenterologie 2003, 41:395-404].
Z Gastroenterol. 2003 Aug;41(8):888-9. German. PubMed PMID: 12910431.


294: Schuppan D, Esslinger B, Dieterich W. Innate immunity and coeliac disease.
Lancet. 2003 Jul 5;362(9377):3-4. PubMed PMID: 12853189.


295: Stickel F, Baumüller HM, Seitz K, Vasilakis D, Seitz G, Seitz HK, Schuppan
D. Hepatitis induced by Kava (Piper methysticum rhizoma). J Hepatol. 2003
Jul;39(1):62-7. PubMed PMID: 12821045.


296: Zeitlin L, Resnick MB, Konikoff F, Schuppan D, Bujanover Y, Lerner A, Belson
A, Lifschitz B, Reif S. Divergent patterns of extracellular matrix protein
expression in neonatal versus adult liver fibrosis. Pediatr Pathol Mol Med. 2003
Jul-Aug;22(4):349-62. PubMed PMID: 14692230.


297: Schuppan D, Esslinger B. [Endemic sprue (celiac disease)--diagnosis,
associated diseases and therapy]. Dtsch Med Wochenschr. 2003 Jun 13;128 Suppl
2:S69-71. Review. German. PubMed PMID: 12817326.


298: Schaefer B, Rivas-Estilla AM, Meraz-Cruz N, Reyes-Romero MA,
Hernández-Nazara ZH, Domínguez-Rosales JA, Schuppan D, Greenwel P, Rojkind M.
Reciprocal modulation of matrix metalloproteinase-13 and type I collagen genes in
rat hepatic stellate cells. Am J Pathol. 2003 Jun;162(6):1771-80. PubMed PMID:
12759235; PubMed Central PMCID: PMC1868138.


299: Rombouts K, Kisanga E, Hellemans K, Wielant A, Schuppan D, Geerts A. Effect
of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat
hepatic stellate cells. J Hepatol. 2003 May;38(5):564-72. PubMed PMID: 12713866.


300: Stickel F, Pöschl G, Seitz HK, Waldherr R, Hahn EG, Schuppan D. Acute
hepatitis induced by Greater Celandine (Chelidonium majus). Scand J
Gastroenterol. 2003 May;38(5):565-8. PubMed PMID: 12795472.


301: Hanke B, Wein A, Martus P, Riedel C, Voelker M, Hahn EG, Schuppan D. Serum
markers of matrix turnover as predictors for the evolution of colorectal cancer
metastasis under chemotherapy. Br J Cancer. 2003 Apr 22;88(8):1248-50. PubMed
PMID: 12698191; PubMed Central PMCID: PMC2747566.


302: Herold C, Ganslmayer M, Ocker M, Zopf S, Gailer B, Hahn EG, Schuppan D.
Inducibility of microsomal liver function may differentiate cirrhotic patients
with maintained compared with severely compromised liver reserve. J Gastroenterol
Hepatol. 2003 Apr;18(4):445-9. PubMed PMID: 12653894.


303: Tilg H, Jalan R, Kaser A, Davies NA, Offner FA, Hodges SJ, Ludwiczek O,
Shawcross D, Zoller H, Alisa A, Mookerjee RP, Graziadei I, Datz C, Trauner M,
Schuppan D, Obrist P, Vogel W, Williams R. Anti-tumor necrosis factor-alpha
monoclonal antibody therapy in severe alcoholic hepatitis. J Hepatol. 2003
Apr;38(4):419-25. PubMed PMID: 12663232.


304: Stickel F, Seitz HK, Hahn EG, Schuppan D. [Alcoholic liver
disease--established treatment and new therapeutic approaches]. Z Gastroenterol.
2003 Apr;41(4):333-42. Review. German. PubMed PMID: 12695940.


305: Sedlaczek N, Hasilik A, Neuhaus P, Schuppan D, Herbst H. Focal
overexpression of insulin-like growth factor 2 by hepatocytes and cholangiocytes
in viral liver cirrhosis. Br J Cancer. 2003 Mar 10;88(5):733-9. PubMed PMID:
12618883; PubMed Central PMCID: PMC2376349.


306: Stölzel U, Köstler E, Schuppan D, Richter M, Wollina U, Doss MO, Wittekind
C, Tannapfel A. Hemochromatosis (HFE) gene mutations and response to chloroquine
in porphyria cutanea tarda. Arch Dermatol. 2003 Mar;139(3):309-13. PubMed PMID:
12622622.


307: Schuppan D, Dieterich W. A molecular warhead and its target: tissue
transglutaminase and Celiac Sprue. Chem Biol. 2003 Mar;10(3):199-201. PubMed
PMID: 12670530.


308: Ott R, Schuppan D, Tannapfel A, Wittekind C, Erhardt W, Henke J, Kilic N,
Köckerling F, Reck T, Hohenberger W, Müller V. Portal vein arterialisation as a
technical option in liver transplantation: impact on function, regeneration, and
morphology of the liver following hemihepatectomy in pigs. Liver Int. 2003
Feb;23(1):54-62. PubMed PMID: 12640728.


309: Schuppan D, Krebs A, Bauer M, Hahn EG. Hepatitis C and liver fibrosis. Cell
Death Differ. 2003 Jan;10 Suppl 1:S59-67. Review. PubMed PMID: 12655347.


310: Herold C, Regn S, Ganslmayer M, Ocker M, Hahn EG, Schuppan D. Can
quantitative tests of liver function discriminate between different etiologies of
liver cirrhosis? Dig Dis Sci. 2002 Dec;47(12):2669-73. PubMed PMID: 12498283.


311: Schuppan D, Popov Y. Hepatic fibrosis: from bench to bedside. J
Gastroenterol Hepatol. 2002 Dec;17 Suppl 3:S300-5. Review. Erratum in: J
Gastroenterol Hepatol. 2008 Sep;23(9):1464. Porov, Yury [corrected to Popov,
Yury]. PubMed PMID: 12472954.


312: Teubner A, Tillmann HL, Schuppan D, Gericke G, Manns MP, Stölzel U.
[Prevalence of circulating autoantibodies in healthy individuals]. Med Klin
(Munich). 2002 Nov 15;97(11):645-9. German. PubMed PMID: 12434272.


313: Isbert C, Boerner A, Ritz JP, Schuppan D, Buhr HJ, Germer CT. In situ
ablation of experimental liver metastases delays and reduces residual
intrahepatic tumour growth and peritoneal tumour spread compared with hepatic
resection. Br J Surg. 2002 Oct;89(10):1252-9. PubMed PMID: 12296892.


314: Schuppan D, Hahn EG. Biomedicine. Gluten and the gut-lessons for immune
regulation. Science. 2002 Sep 27;297(5590):2218-20. PubMed PMID: 12351776.


315: Rombouts K, Niki T, Greenwel P, Vandermonde A, Wielant A, Hellemans K, De
Bleser P, Yoshida M, Schuppan D, Rojkind M, Geerts A. Trichostatin A, a histone
deacetylase inhibitor, suppresses collagen synthesis and prevents
TGF-beta(1)-induced fibrogenesis in skin fibroblasts. Exp Cell Res. 2002 Aug
15;278(2):184-97. PubMed PMID: 12169274.


316: Ruehl M, Somasundaram R, Schoenfelder I, Farndale RW, Knight CG, Schmid M,
Ackermann R, Riecken EO, Zeitz M, Schuppan D. The epithelial mitogen keratinocyte
growth factor binds to collagens via the consensus sequence
glycine-proline-hydroxyproline. J Biol Chem. 2002 Jul 26;277(30):26872-8. Epub
2002 Apr 24. PubMed PMID: 11973338.


317: Stickel F, Schuppan D, Hahn EG, Seitz HK. Cocarcinogenic effects of alcohol
in hepatocarcinogenesis. Gut. 2002 Jul;51(1):132-9. Review. PubMed PMID:
12077107; PubMed Central PMCID: PMC1773267.


318: Stickel F, Brinkhaus B, Krähmer N, Seitz HK, Hahn EG, Schuppan D.
Antifibrotic properties of botanicals in chronic liver disease.
Hepatogastroenterology. 2002 Jul-Aug;49(46):1102-8. Review. PubMed PMID:
12143213.


319: Herold C, Wehler M, Schuppan D, Hahn EG, Strauss R. Changes in hepatic
perfusion after administration of hydroxyethyl starch in intensive care patients
assessed using color-coded Doppler sonography. Clin Imaging. 2002
May-Jun;26(3):173-6. PubMed PMID: 11983469.


320: Herold C, Ganslmayer M, Deynet C, Hahn EG, Schuppan D. Quantitative testing
of liver function compared to prognostic scores in patients with primary biliary
cirrhosis. Liver. 2002 Apr;22(2):159-65. PubMed PMID: 12028411.


321: Lorentz A, Schuppan D, Gebert A, Manns MP, Bischoff SC. Regulatory effects
of stem cell factor and interleukin-4 on adhesion of human mast cells to
extracellular matrix proteins. Blood. 2002 Feb 1;99(3):966-72. PubMed PMID:
11807000.


322: Herold C, Ocker M, Ganslmayer M, Gerauer H, Hahn EG, Schuppan D.
Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal
carcinoma cells. Br J Cancer. 2002 Feb 1;86(3):443-8. PubMed PMID: 11875713;
PubMed Central PMCID: PMC2375221.


323: Stölzel U, Schuppan D, Tillmann HL, Manns MP, Tannapfel A, Doss MO, Zimmer
T, Köstler E. Autoimmunity and HCV infection in porphyria cutanea tarda: a
controlled study. Cell Mol Biol (Noisy-le-grand). 2002 Feb;48(1):43-7. PubMed
PMID: 11929046.


324: Raetsch C, Jia JD, Boigk G, Bauer M, Hahn EG, Riecken EO, Schuppan D.
Pentoxifylline downregulates profibrogenic cytokines and procollagen I expression
in rat secondary biliary fibrosis. Gut. 2002 Feb;50(2):241-7. PubMed PMID:
11788567; PubMed Central PMCID: PMC1773098.


325: Somasundaram R, Ruehl M, Schaefer B, Schmid M, Ackermann R, Riecken EO,
Zeitz M, Schuppan D. Interstitial collagens I, III, and VI sequester and modulate
the multifunctional cytokine oncostatin M. J Biol Chem. 2002 Feb 1;277(5):3242-6.
Epub 2001 Nov 15. PubMed PMID: 11711546.


326: Herold C, Ganslmayer M, Ocker M, Hermann M, Geerts A, Hahn EG, Schuppan D.
The histone-deacetylase inhibitor Trichostatin A blocks proliferation and
triggers apoptotic programs in hepatoma cells. J Hepatol. 2002 Feb;36(2):233-40.
PubMed PMID: 11830335.


327: Herold C, Reck T, Fischler P, Ott R, Radespiel-Troeger M, Ganslmayer M,
Hohenberger W, Hahn EG, Schuppan D. Prognosis of a large cohort of patients with
hepatocellular carcinoma in a single European centre. Liver. 2002 Feb;22(1):23-8.
PubMed PMID: 11906615.


328: Schuppan D, Ciccocioppo R. Coeliac disease and secondary autoimmunity. Dig
Liver Dis. 2002 Jan;34(1):13-5. PubMed PMID: 11926568.


329: Herold C, Ganslmayer M, Ocker M, Hermann M, Hahn EG, Schuppan D. Combined in
vitro anti-tumoral action of tamoxifen and retinoic acid derivatives in hepatoma
cells. Int J Oncol. 2002 Jan;20(1):89-96. PubMed PMID: 11743647.


330: Guenther U, Herbst H, Bauer M, Isbert C, Buhr HJ, Riecken EO, Schuppan D.
Collagen type XVIII/endostatin is differentially expressed in primary and
metastatic colorectal cancers and ovarian carcinomas. Br J Cancer. 2001 Nov
16;85(10):1540-5. PubMed PMID: 11720442; PubMed Central PMCID: PMC2363956.


331: Herold C, Reck T, Ott R, Schneider HT, Becker D, Schuppan D, Hahn EG.
Contrast-enhanced ultrasound improves hepatic vessel visualization after
orthotopic liver transplantation. Abdom Imaging. 2001 Nov-Dec;26(6):597-600.
PubMed PMID: 11907724.


332: Warzecha Z, Dembiński A, Konturek PC, Ceranowicz P, Konturek SJ, Tomaszewska
R, Schuppan D, Stachura J, Nakamura T. Hepatocyte growth factor attenuates
pancreatic damage in caerulein-induced pancreatitis in rats. Eur J Pharmacol.
2001 Oct 26;430(1):113-21. PubMed PMID: 11698071.


333: Melgert BN, Olinga P, Van Der Laan JM, Weert B, Cho J, Schuppan D, Groothuis
GM, Meijer DK, Poelstra K. Targeting dexamethasone to Kupffer cells: effects on
liver inflammation and fibrosis in rats. Hepatology. 2001 Oct;34(4 Pt 1):719-28.
PubMed PMID: 11584368.


334: Rombouts K, Wielant A, Hellemans K, Schuppan D, Geerts A. Influence of
aldosterone on collagen synthesis and proliferation of rat cardiac fibroblasts.
Br J Pharmacol. 2001 Sep;134(1):224-32. PubMed PMID: 11522615; PubMed Central
PMCID: PMC1572936.


335: Stickel F, Urbaschek R, Schuppan D, Poeschl G, Oesterling C, Conradt C,
McCuskey RS, Simanowski UA, Seitz HK. Serum collagen type VI and XIV and
hyaluronic acid as early indicators for altered connective tissue turnover in
alcoholic liver disease. Dig Dis Sci. 2001 Sep;46(9):2025-32. PubMed PMID:
11575459.


336: Jia JD, Bauer M, Cho JJ, Ruehl M, Milani S, Boigk G, Riecken EO, Schuppan D.
Antifibrotic effect of silymarin in rat secondary biliary fibrosis is mediated by
downregulation of procollagen alpha1(I) and TIMP-1. J Hepatol. 2001
Sep;35(3):392-8. PubMed PMID: 11592601.


337: Jia JD, Bauer M, Sedlaczek N, Herbst H, Ruehl M, Hahn EG, Riecken EO,
Schuppan D. Modulation of collagen XVIII/endostatin expression in lobular and
biliary rat liver fibrogenesis. J Hepatol. 2001 Sep;35(3):386-91. PubMed PMID:
11592600.


338: Herold C, Heinz R, Niedobitek G, Schneider T, Hahn EG, Schuppan D.
Quantitative testing of liver function in relation to fibrosis in patients with
chronic hepatitis B and C. Liver. 2001 Aug;21(4):260-5. PubMed PMID: 11454189.


339: Schuppan D, Ruehl M, Somasundaram R, Hahn EG. Matrix as a modulator of
hepatic fibrogenesis. Semin Liver Dis. 2001 Aug;21(3):351-72. Review. PubMed
PMID: 11586465.


340: Bauer M, Schuppan D. TGFbeta1 in liver fibrosis: time to change paradigms?
FEBS Lett. 2001 Jul 27;502(1-2):1-3. Review. PubMed PMID: 11478937.


341: Tannapfel A, Stölzel U, Köstler E, Melz S, Richter M, Keim V, Schuppan D,
Wittekind C. C282Y and H63D mutation of the hemochromatosis gene in German
porphyria cutanea tarda patients. Virchows Arch. 2001 Jul;439(1):1-5. PubMed
PMID: 11499833.


342: Shahin M, Konturek JW, Pohle T, Schuppan D, Herbst H, Domschke W. Remodeling
of extracellular matrix in gastric ulceration. Microsc Res Tech. 2001 Jun
15;53(6):396-408. PubMed PMID: 11525257.


343: Schuppan D, Hahn EG. IgA anti-tissue transglutaminase: setting the stage for
coeliac disease screening. Eur J Gastroenterol Hepatol. 2001 Jun;13(6):635-7.
Review. PubMed PMID: 11434587.


344: Badenhoop K, Dieterich W, Segni M, Hofmann S, Hüfner M, Usadel KH, Hahn EG,
Schuppan D. HLA DQ2 and/or DQ8 is associated with celiac disease-specific
autoantibodies to tissue transglutaminase in families with thyroid autoimmunity.
Am J Gastroenterol. 2001 May;96(5):1648-9. PubMed PMID: 11374722.


345: Sedlaczek N, Jia JD, Bauer M, Herbst H, Ruehl M, Hahn EG, Schuppan D.
Proliferating bile duct epithelial cells are a major source of connective tissue
growth factor in rat biliary fibrosis. Am J Pathol. 2001 Apr;158(4):1239-44.
PubMed PMID: 11290541; PubMed Central PMCID: PMC1891909.


346: Stickel F, Seitz HK, Hahn EG, Schuppan D. [Liver toxicity of drugs of plant
origin]. Z Gastroenterol. 2001 Mar;39(3):225-32, 234-7. Review. German. PubMed
PMID: 11324140.


347: Schuppan D, Hahn EG. Clinical studies with silymarin: fibrosis progression
is the end point. Hepatology. 2001 Feb;33(2):483-4. PubMed PMID: 11172360.


348: Rombouts K, Niki T, Wielant A, Hellemans K, Schuppan D, Kormoss N, Geerts A.
Effect of aldosterone on collagen steady state levels in primary and subcultured
rat hepatic stellate cells. J Hepatol. 2001 Feb;34(2):230-8. PubMed PMID:
11281551.


349: Herold C, Heinz R, Radespiel-Tröger M, Schneider HT, Schuppan D, Hahn EG.
Quantitative testing of liver function in patients with cirrhosis due to chronic
hepatitis C to assess disease severity. Liver. 2001 Feb;21(1):26-30. PubMed PMID:
11169069.


350: Herold C, Reck T, Ott R, Becker D, Schneider HT, Schuppan D, Hahn EG.
Changes in hepatic hemodynamics after orthotopic liver transplantation: color
Doppler sonography. Abdom Imaging. 2001 Jan-Feb;26(1):32-5. PubMed PMID:
11116356.


351: Brzozowski T, Konturek PC, Konturek SJ, Schuppan D, Drozdowicz D, Kwiecień
S, Majka J, Nakamura T, Hahn E. Effect of local application of growth factors on
gastric ulcer healing and mucosal expression of cyclooxygenase-1 and -2.
Digestion. 2001;64(1):15-29. PubMed PMID: 11549833.


352: Guirouilh J, Le Bail B, Boussarie L, Balabaud C, Bioulac-Sage P, Desmoulière
A, Schuppan D, Rosenbaum J. Expression of hepatocyte growth factor in human
hepatocellular carcinoma. J Hepatol. 2001 Jan;34(1):78-83. PubMed PMID: 11211911.


353: Schuppan D, Hahn EG. Celiac disease and its link to type 1 diabetes
mellitus. J Pediatr Endocrinol Metab. 2001;14 Suppl 1:597-605. Review. PubMed
PMID: 11393550.


354: Somasundaram R, Ruehl M, Tiling N, Ackermann R, Schmid M, Riecken EO,
Schuppan D. Collagens serve as an extracellular store of bioactive interleukin 2.
J Biol Chem. 2000 Dec 8;275(49):38170-5. PubMed PMID: 10982811.


355: Konturek PC, Karczewska E, Dieterich W, Hahn EG, Schuppan D. Increased
prevalence of Helicobacter pylori infection in patients with celiac disease. Am J
Gastroenterol. 2000 Dec;95(12):3682-3. PubMed PMID: 11151941.


356: Brzozowski T, Konturek PC, Konturek SJ, Pajdo R, Schuppan D, Drozdowicz D,
Ptak A, Pawlik M, Nakamura T, Hahn EG. Involvement of cyclooxygenase (COX)-2
products in acceleration of ulcer healing by gastrin and hepatocyte growth
factor. J Physiol Pharmacol. 2000 Dec;51(4 Pt 1):751-73. PubMed PMID: 11192947.


357: Herold C, Berg P, Kupfal D, Becker D, Schuppan D, Hahn EG, Schneider HT.
Parameters of microsomal and cytosolic liver function but not of liver perfusion
predict portal vein velocity in noncirrhotic patients with chronic hepatitis C.
Dig Dis Sci. 2000 Nov;45(11):2233-7. PubMed PMID: 11215745.


358: Schuppan D, Hahn EG. Interleukin 10: the magic bullet for liver fibrosis?
Gastroenterology. 2000 Nov;119(5):1412-4. PubMed PMID: 11185462.


359: Rothermund L, Cho JJ, Leggewie S, Schwarz A, Bauer C, Paul M, Neumayer HH,
Schuppan D, Hocher B. Activation of the hepatic endothelin-system in rats with
biliary liver fibrosis. J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S270-3.
PubMed PMID: 11078396.


360: Stölzel U, Schuppan D, Tillmann HL, Manns MP, Tannapfel A, Doss MO, Zimmer
T, Koszka C, Köstler E. Autoantibodies in porphyria cutanea tarda: a controlled
study. J Hepatol. 2000 Nov;33(5):858-9. PubMed PMID: 11097501.


361: Schuppan D, Koda M, Bauer M, Hahn EG. Fibrosis of liver, pancreas and
intestine: common mechanisms and clear targets? Acta Gastroenterol Belg. 2000
Oct-Dec;63(4):366-70. Review. PubMed PMID: 11233519.


362: Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and
clinical profile of the East Asian medical plant Centella asiatica.
Phytomedicine. 2000 Oct;7(5):427-48. Review. PubMed PMID: 11081995.


363: Jia J, Bauer M, Boigk G, Ruehl M, Schuppan D, Wang B. [Expression of
collagen XVIII mRNA in rat liver fibrosis]. Zhonghua Gan Zang Bing Za Zhi. 2000
Oct;8(5):274-5. Chinese. PubMed PMID: 11058949.


364: Stölzel U, Tannapfel A, Wittekind C, Hamm B, Schuppan D. [Indications for
liver biopsy in liver tumors]. Dtsch Med Wochenschr. 2000 Sep 8;125(36):1041-4.
Review. German. PubMed PMID: 11022600.


365: Stallmach A, Chan CC, Ecker KW, Feifel G, Herbst H, Schuppan D, Zeitz M.
Comparable expression of matrix metalloproteinases 1 and 2 in pouchitis and
ulcerative colitis. Gut. 2000 Sep;47(3):415-22. PubMed PMID: 10940281; PubMed
Central PMCID: PMC1728023.


366: Schuppan D. Current concepts of celiac disease pathogenesis.
Gastroenterology. 2000 Jul;119(1):234-42. Review. PubMed PMID: 10889174.


367: Schuppan D, Hahn EG. MMPs in the gut: inflammation hits the matrix. Gut.
2000 Jul;47(1):12-4. PubMed PMID: 10861255; PubMed Central PMCID: PMC1727957.


368: Rothermund L, Leggewie S, Schwarz A, Thöne-Reinecke C, Cho JJ, Bauer C, Paul
M, Neumayer HH, Schuppan D, Hocher B. Regulation of the hepatic endothelin system
in advanced biliary fibrosis in rats. Clin Chem Lab Med. 2000 Jun;38(6):507-12.
PubMed PMID: 10987198.


369: Kordonouri O, Dieterich W, Schuppan D, Webert G, Müller C, Sarioglu N,
Becker M, Danne T. Autoantibodies to tissue transglutaminase are sensitive
serological parameters for detecting silent coeliac disease in patients with Type
1 diabetes mellitus. Diabet Med. 2000 Jun;17(6):441-4. PubMed PMID: 10975212.


370: Cho JJ, Hocher B, Herbst H, Jia JD, Ruehl M, Hahn EG, Riecken EO, Schuppan
D. An oral endothelin-A receptor antagonist blocks collagen synthesis and
deposition in advanced rat liver fibrosis. Gastroenterology. 2000
Jun;118(6):1169-78. PubMed PMID: 10833492.


371: Dormann H, Krebs S, Muth-Selbach U, Brune K, Schuppan D, Hahn EG, Schneider
HT. Rapid onset of hematotoxic effects after interferon alpha in hepatitis C. J
Hepatol. 2000 Jun;32(6):1041-2. PubMed PMID: 10898329.


372: Beljaars L, Molema G, Schuppan D, Geerts A, De Bleser PJ, Weert B, Meijer
DK, Poelstra K. Successful targeting to rat hepatic stellate cells using albumin
modified with cyclic peptides that recognize the collagen type VI receptor. J
Biol Chem. 2000 Apr 28;275(17):12743-51. PubMed PMID: 10777570.


373: Schuppan D. [LIVER FIBROSIS: PATHOGENESIS,PREVENTION AND TREATMENT]. Rev
Gastroenterol Peru. 2000 Apr-Jun;20(2):164-168. Spanish. PubMed PMID: 12140600.


374: Johannsen M, Rühl M, Manski D, Somasundaram R, Riecken EO, Schuppan D.
Native extraction of phosphotyrosine-containing proteins: requirement of tyrosine
kinase inhibitors to obtain specific phosphorylation signals. Anal Biochem. 2000
Mar 15;279(2):242-5. PubMed PMID: 10706794.


375: Ropers T, Kroll W, Becka M, Voelker M, Burchardt ER, Schuppan D, Gehrmann M.
Enzyme immunoassay for the measurement of human tenascin-C on the Bayer Immuno 1
analyzer. Clin Biochem. 2000 Feb;33(1):7-13. PubMed PMID: 10693981.


376: Dieterich W, Storch WB, Schuppan D. Serum antibodies in celiac disease. Clin
Lab. 2000;46(7-8):361-4. Review. PubMed PMID: 10934583.


377: Dieterich W, Riecken EO, Schuppan D. Immunoassay for detection of IgA
antitissue transglutaminase in patients with celiac disease. Methods Mol Med.
2000;41:241-5. doi: 10.1385/1-59259-082-9:241. PubMed PMID: 21374443.


378: Rose C, Dieterich W, Bröcker EB, Schuppan D, Zillikens D. Circulating
autoantibodies to tissue transglutaminase differentiate patients with dermatitis
herpetiformis from those with linear IgA disease. J Am Acad Dermatol. 1999
Dec;41(6):957-61. PubMed PMID: 10570380.


379: Rühl M, Sahin E, Johannsen M, Somasundaram R, Manski D, Riecken EO, Schuppan
D. Soluble collagen VI drives serum-starved fibroblasts through S phase and
prevents apoptosis via down-regulation of Bax. J Biol Chem. 1999 Nov
26;274(48):34361-8. PubMed PMID: 10567413.


380: Benninger J, Schneider HT, Schuppan D, Kirchner T, Hahn EG. Acute hepatitis
induced by greater celandine (Chelidonium majus). Gastroenterology. 1999
Nov;117(5):1234-7. PubMed PMID: 10535888.


381: Löhr M, Hummel F, Martus P, Cidlinsky K, Kröger JC, Hahn EG, Oesterling C,
Emmrich J, Schuppan D, Liebe S. Serum levels of extracellular matrix in acute
pancreatitis. Hepatogastroenterology. 1999 Nov-Dec;46(30):3263-70. PubMed PMID:
10626198.


382: Rudolph KL, Trautwein C, Kubicka S, Rakemann T, Bahr MJ, Sedlaczek N,
Schuppan D, Manns MP. Differential regulation of extracellular matrix synthesis
during liver regeneration after partial hepatectomy in rats. Hepatology. 1999
Nov;30(5):1159-66. PubMed PMID: 10534336.


383: Pfander D, Cramer T, Weseloh G, Pullig O, Schuppan D, Bauer M, Swoboda B.
Hepatocyte growth factor in human osteoarthritic cartilage. Osteoarthritis
Cartilage. 1999 Nov;7(6):548-59. PubMed PMID: 10558853.


384: Schuppan D, Jax C, Hahn EG. [Serum markers of liver fibrosis]. Dtsch Med
Wochenschr. 1999 Oct 15;124(41):1213-8. Review. German. PubMed PMID: 10572522.


385: Schuppan D, Jia JD, Brinkhaus B, Hahn EG. Herbal products for liver
diseases: a therapeutic challenge for the new millennium. Hepatology. 1999
Oct;30(4):1099-104. Review. PubMed PMID: 10498665.


386: Günther U, Schuppan D, Bauer M, Matthes H, Stallmach A, Schmitt-Gräff A,
Riecken EO, Herbst H. Fibrogenesis and fibrolysis in collagenous colitis.
Patterns of procollagen types I and IV, matrix-metalloproteinase-1 and -13, and
TIMP-1 gene expression. Am J Pathol. 1999 Aug;155(2):493-503. PubMed PMID:
10433942; PubMed Central PMCID: PMC1866842.


387: Rühl M, Johannsen M, Atkinson J, Manski D, Sahin E, Somasundaram R, Riecken
EO, Schuppan D. Soluble collagen VI induces tyrosine phosphorylation of paxillin
and focal adhesion kinase and activates the MAP kinase erk2 in fibroblasts. Exp
Cell Res. 1999 Aug 1;250(2):548-57. PubMed PMID: 10413607.


388: Dalkowski A, Schuppan D, Orfanos CE, Zouboulis CC. Increased expression of
tenascin C by keloids in vivo and in vitro. Br J Dermatol. 1999 Jul;141(1):50-6.
PubMed PMID: 10417515.


389: Hellemans K, Grinko I, Rombouts K, Schuppan D, Geerts A. All-trans and 9-cis
retinoic acid alter rat hepatic stellate cell phenotype differentially. Gut. 1999
Jul;45(1):134-42. PubMed PMID: 10369717; PubMed Central PMCID: PMC1727592.


390: Dieterich W, Laag E, Bruckner-Tuderman L, Reunala T, Kárpáti S, Zágoni T,
Riecken EO, Schuppan D. Antibodies to tissue transglutaminase as serologic
markers in patients with dermatitis herpetiformis. J Invest Dermatol. 1999
Jul;113(1):133-6. PubMed PMID: 10417632.


391: Anagnostopoulos I, Schuppan D, Riecken EO, Gross UM, Stein H. Tenascin
labelling in colorectal biopsies: a useful marker in the diagnosis of collagenous
colitis. Histopathology. 1999 May;34(5):425-31. PubMed PMID: 10231417.


392: Niki T, Rombouts K, De Bleser P, De Smet K, Rogiers V, Schuppan D, Yoshida
M, Gabbiani G, Geerts A. A histone deacetylase inhibitor, trichostatin A,
suppresses myofibroblastic differentiation of rat hepatic stellate cells in
primary culture. Hepatology. 1999 Mar;29(3):858-67. PubMed PMID: 10051490.


393: Schuppan D, Cho JJ, Jia JD, Hahn EG. Interplay of matrix and myofibroblasts
during hepatic fibrogenesis. Curr Top Pathol. 1999;93:205-18. Review. PubMed
PMID: 10339913.


394: Daum S, Bauer U, Foss HD, Schuppan D, Stein H, Riecken EO, Ullrich R.
Increased expression of mRNA for matrix metalloproteinases-1 and -3 and tissue
inhibitor of metalloproteinases-1 in intestinal biopsy specimens from patients
with coeliac disease. Gut. 1999 Jan;44(1):17-25. PubMed PMID: 9862821; PubMed
Central PMCID: PMC1760063.


395: Dieterich W, Laag E, Schöpper H, Volta U, Ferguson A, Gillett H, Riecken EO,
Schuppan D. Autoantibodies to tissue transglutaminase as predictors of celiac
disease. Gastroenterology. 1998 Dec;115(6):1317-21. PubMed PMID: 9834256.


396: Riecken EO, Daum S, Schulzke JD, Dieterich W, Schuppan D. [Tissue
transglutaminase as autoantigen in endemic sprue. New aspects in diagnosis and
etiopathogenesis]. Dtsch Med Wochenschr. 1998 Nov 27;123(48):1454-60. Review.
German. PubMed PMID: 9858954.


397: Daum S, Bauer U, Foss HD, Wahnschaffe U, Schuppan D, Stein H, Riecken EO,
Ullrich R. Expression of matrix metalloprotease-1 and collagen I mRNA in biopsies
from patients with celiac disease. Ann N Y Acad Sci. 1998 Nov 17;859:254-7.
PubMed PMID: 9928399.


398: Günther U, Matthes H, Herbst H, Stallmach A, Riecken EO, Schuppan D.
Phenotype of cells expressing matrix metalloproteinase-3 in ulcerative colitis.
Ann N Y Acad Sci. 1998 Nov 17;859:237-40. PubMed PMID: 9928396.


399: Schuppan D, Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO.
Identification of the autoantigen of celiac disease. Ann N Y Acad Sci. 1998 Nov
17;859:121-6. Review. PubMed PMID: 9928375.


400: Schuppan D, Cramer T, Bauer M, Strefeld T, Hahn EG, Herbst H. Hepatocytes as
a source of collagen type XVIII endostatin. Lancet. 1998 Sep 12;352(9131):879-80.
PubMed PMID: 9742985.

401: Pender SL, Breese EJ, Günther U, Howie D, Wathen NC, Schuppan D, MacDonald
TT. Suppression of T cell-mediated injury in human gut by interleukin 10: role of
matrix metalloproteinases. Gastroenterology. 1998 Sep;115(3):573-83. PubMed PMID:
9721154.


402: Mueller AR, Platz KP, Heckert C, Häusler M, Schuppan D, Lobeck H, Neuhaus P.
Differentiation between preservation reperfusion injury and acute rejection after
small bowel transplantation. Transplant Proc. 1998 Sep;30(6):2657-9. PubMed PMID:
9745536.


403: Mueller AR, Platz KP, Heckert C, Häusler M, Guckelberger O, Schuppan D,
Lobeck H, Neuhaus P. Extracellular matrix: an early target of
preservation/reperfusion injury and acute rejection after small bowel
transplantation. Transplant Proc. 1998 Sep;30(6):2569-71. PubMed PMID: 9745492.


404: Schuppan D, Strobel D, Hahn EG. Hepatic fibrosis - therapeutic strategies.
Digestion. 1998 Jul-Aug;59(4):385-90. Review. PubMed PMID: 9693214.


405: Schuppan D, Dieterich W, Riecken EO. Exposing gliadin as a tasty food for
lymphocytes. Nat Med. 1998 Jun;4(6):666-7. PubMed PMID: 9623970.


406: Mueller AR, Platz KP, Heckert C, Häusler M, Guckelberger O, Schuppan D,
Lobeck H, Neuhaus P. The extracellular matrix: an early target of
preservation/reperfusion injury and acute rejection after small bowel
transplantation. Transplantation. 1998 Mar 27;65(6):770-6. PubMed PMID: 9539087.


407: Ehnis T, Dieterich W, Bauer M, Schuppan D. Localization of a cell adhesion
site on collagen XIV (undulin). Exp Cell Res. 1998 Mar 15;239(2):477-80. PubMed
PMID: 9521866.


408: Atherton AJ, Warburton MJ, O'Hare MJ, Monaghan P, Schuppan D, Gusterson BA.
Differential expression of type XIV collagen/undulin by human mammary gland
intralobular and interlobular fibroblasts. Cell Tissue Res. 1998
Mar;291(3):507-11. PubMed PMID: 9477307.


409: Zimmer T, Rucktäschel F, Stölzel U, Liehr RM, Schuppan D, Stallmach A, Zeitz
M, Weber E, Riecken EO. Endoscopic sclerotherapy with fibrin glue as compared
with polidocanol to prevent early esophageal variceal rebleeding. J Hepatol. 1998
Feb;28(2):292-7. PubMed PMID: 9514542.


410: Genersch E, Schneider DW, Sauer G, Khazaie K, Schuppan D, Lichtner RB.
Prevention of EGF-modulated adhesion of tumor cells to matrix proteins by
specific EGF receptor inhibition. Int J Cancer. 1998 Jan 19;75(2):205-9. PubMed
PMID: 9462709.


411: Schuppan D, Schmid M, Somasundaram R, Ackermann R, Ruehl M, Nakamura T,
Riecken EO. Collagens in the liver extracellular matrix bind hepatocyte growth
factor. Gastroenterology. 1998 Jan;114(1):139-52. PubMed PMID: 9428228.


412: Albrecht D, Germer CT, Pelz J, Isbert C, Ritz JP, Schuppan D, Buhr HJ.
[Significant modification of the hyperthermic effect by starch microspheres
(Spherex) of laser-induced hypertheria in the rat liver metastasis model].
Langenbecks Arch Chir Suppl Kongressbd. 1998;115(Suppl I):607-9. German. PubMed
PMID: 14518326.


413: Isbert C, Germer CT, Albrecht D, Thomsen-Mund K, Schuppan D, Buhr HJ.
[Overexpression of B7-1 amd B7-2 by LFA-1 positive lymphocytes in chronic
inflammatory bowel diseases]. Langenbecks Arch Chir Suppl Kongressbd.
1998;115(Suppl I):213-6. German. PubMed PMID: 14518246.


414: Graf R, Matejevic D, Schuppan D, Neudeck H, Shakibaei M, Vetter K. Molecular
anatomy of the perivascular sheath in human placental stem villi: the contractile
apparatus and its association to the extracellular matrix. Cell Tissue Res. 1997
Dec;290(3):601-7. PubMed PMID: 9369535.


415: Bauer M, Dieterich W, Ehnis T, Schuppan D. Complete primary structure of
human collagen type XIV (undulin). Biochim Biophys Acta. 1997 Nov
20;1354(3):183-8. PubMed PMID: 9427527.


416: Boigk G, Stroedter L, Herbst H, Waldschmidt J, Riecken EO, Schuppan D.
Silymarin retards collagen accumulation in early and advanced biliary fibrosis
secondary to complete bile duct obliteration in rats. Hepatology. 1997
Sep;26(3):643-9. PubMed PMID: 9303494.


417: Ehnis T, Dieterich W, Bauer M, Kresse H, Schuppan D. Localization of a
binding site for the proteoglycan decorin on collagen XIV (undulin). J Biol Chem.
1997 Aug 15;272(33):20414-9. PubMed PMID: 9252349.


418: Shahin M, Gillessen A, Pohle T, Weber C, Schuppan D, Herbst H, Domschke W.
Gastric ulcer healing in the rat: kinetics and localisation of de novo
procollagen synthesis. Gut. 1997 Aug;41(2):187-94. PubMed PMID: 9301497; PubMed
Central PMCID: PMC1891472.


419: Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO, Schuppan D.
Identification of tissue transglutaminase as the autoantigen of celiac disease.
Nat Med. 1997 Jul;3(7):797-801. PubMed PMID: 9212111.


420: Gerling B, Becker M, Staab D, Schuppan D. Prediction of liver fibrosis
according to serum collagen VI level in children with cystic fibrosis. N Engl J
Med. 1997 May 29;336(22):1611-2. PubMed PMID: 9173266.


421: Herbst H, Wege T, Milani S, Pellegrini G, Orzechowski HD, Bechstein WO,
Neuhaus P, Gressner AM, Schuppan D. Tissue inhibitor of metalloproteinase-1 and
-2 RNA expression in rat and human liver fibrosis. Am J Pathol. 1997
May;150(5):1647-59. PubMed PMID: 9137090; PubMed Central PMCID: PMC1858217.


422: Herbst H, Frey A, Heinrichs O, Milani S, Bechstein WO, Neuhaus P, Schuppan
D. Heterogeneity of liver cells expressing procollagen types I and IV in vivo.
Histochem Cell Biol. 1997 May;107(5):399-409. PubMed PMID: 9208331.


423: Klugewitz K, Ley K, Schuppan D, Nuck R, Gaehtgens P, Walzog B. Activation of
the beta2 integrin Mac-1 (CD11b/CD18) by an endogenous lipid mediator of human
neutrophils and HL-60 cells. J Cell Sci. 1997 Apr;110 ( Pt 8):985-90. PubMed
PMID: 9152024.


424: Göpel C, Schultka R, Schuppan D. [Age-dependent distribution of collagen and
glycoproteins in the blood vessels of the human uterine tube]. Ann Anat. 1997
Feb;179(1):83-8. German. PubMed PMID: 9092299.


425: Tschoetschel U, Schwing J, Frosch S, Schmitt E, Schuppan D, Reske-Kunz AB.
Modulation of proliferation and lymphokine secretion of murine CD4+ T cells and
cloned Th1 cells by proteins of the extracellular matrix. Int Immunol. 1997
Jan;9(1):147-59. PubMed PMID: 9043956.


426: Ehnis T, Dieterich W, Bauer M, Lampe B, Schuppan D. A chondroitin/dermatan
sulfate form of CD44 is a receptor for collagen XIV (undulin). Exp Cell Res. 1996
Dec 15;229(2):388-97. PubMed PMID: 8986622.


427: Atkinson JC, Rühl M, Becker J, Ackermann R, Schuppan D. Collagen VI
regulates normal and transformed mesenchymal cell proliferation in vitro. Exp
Cell Res. 1996 Nov 1;228(2):283-91. PubMed PMID: 8912722.


428: Somasundaram R, Schuppan D. Type I, II, III, IV, V, and VI collagens serve
as extracellular ligands for the isoforms of platelet-derived growth factor (AA,
BB, and AB). J Biol Chem. 1996 Oct 25;271(43):26884-91. PubMed PMID: 8900172.


429: Pohle T, Shahin M, Gillessen A, Schuppan D, Herbst H, Domschke W. Expression
of type I and IV collagen mRNAs in healing gastric ulcers--a comparative analysis
using isotopic and non-radioactive in situ hybridization. Histochem Cell Biol.
1996 Oct;106(4):413-8. PubMed PMID: 8911969.


430: Genersch E, Schuppan D, Lichtner RB. Signaling by epidermal growth factor
differentially affects integrin-mediated adhesion of tumor cells to extracellular
matrix proteins. J Mol Med (Berl). 1996 Oct;74(10):609-16. PubMed PMID: 8912181.


431: Gerling B, Becker M, Waldschmidt J, Rehmann M, Schuppan D. Elevated serum
aminoterminal procollagen type-III-peptide parallels collagen accumulation in
rats with secondary biliary fibrosis. J Hepatol. 1996 Jul;25(1):79-84. PubMed
PMID: 8836905.


432: Niki T, Schuppan D, de Bleser PJ, Vrijsen R, Pipeleers-Marichal M, Beyaert
R, Wisse E, Geerts A. Dexamethasone alters messenger RNA levels but not synthesis
of collagens, fibronectin, or laminin by cultured rat fat-storing cells.
Hepatology. 1996 Jun;23(6):1673-81. PubMed PMID: 8675192.


433: Löster K, Zeilinger K, Schuppan D, Reutter W. The cysteine-rich region of
dipeptidyl peptidase IV (CD 26) is the collagen-binding site. Biochem Biophys Res
Commun. 1995 Dec 5;217(1):341-8. PubMed PMID: 8526932.


434: Marder K, Keller F, Schuppan D. Circulating type VI collagen and undulin, in
patients with kidney diseases, after kidney transplantation and on hemodialysis.
Clin Nephrol. 1995 Sep;44(3):178-84. PubMed PMID: 8556834.


435: Blazejewski S, Preaux AM, Mallat A, Brocheriou I, Mavier P, Dhumeaux D,
Hartmann D, Schuppan D, Rosenbaum J. Human myofibroblastlike cells obtained by
outgrowth are representative of the fibrogenic cells in the liver. Hepatology.
1995 Sep;22(3):788-97. PubMed PMID: 7657284.


436: Schuppan D, Atkinson J, Ruehl M, Riecken EO. Alcohol and liver
fibrosis--pathobiochemistry and treatment. Z Gastroenterol. 1995
Sep;33(9):546-50. Review. PubMed PMID: 8525660.


437: Winwood PJ, Schuppan D, Iredale JP, Kawser CA, Docherty AJ, Arthur MJ.
Kupffer cell-derived 95-kd type IV collagenase/gelatinase B: characterization and
expression in cultured cells. Hepatology. 1995 Jul;22(1):304-15. PubMed PMID:
7601425.


438: Stölzel U, Köstler E, Koszka C, Stöffler-Meilicke M, Schuppan D,
Somasundaram R, Doss MO, Habermehl KO, Riecken EO. Low prevalence of hepatitis C
virus infection in porphyria cutanea tarda in Germany. Hepatology. 1995
Jun;21(6):1500-3. PubMed PMID: 7539393.


439: Walzog B, Schuppan D, Heimpel C, Hafezi-Moghadam A, Gaehtgens P, Ley K. The
leukocyte integrin Mac-1 (CD11b/CD18) contributes to binding of human
granulocytes to collagen. Exp Cell Res. 1995 May;218(1):28-38. PubMed PMID:
7737365.


440: Becker J, Schuppan D. Altered expression of extracellular matrix proteins
and integrins in oral lichen planus (OLP). J Oral Pathol Med. 1995
Apr;24(4):159-64. PubMed PMID: 7540204.


441: Rasmussen LH, Garbarsch C, Schuppan D, Moe D, Hørslev-Pedersen K, Gottrup F,
Steenfos H. Dose response profiles of human growth hormone in subcutaneous wound
chambers in rats. Eur J Surg. 1995 Mar;161(3):157-62. PubMed PMID: 7599293.


442: Keller F, Heinze H, Jochimsen F, Passfall J, Schuppan D, Büttner P. Risk
factors and outcome of 107 patients with decompensated liver disease and acute
renal failure (including 26 patients with hepatorenal syndrome): the role of
hemodialysis. Ren Fail. 1995 Mar;17(2):135-46. PubMed PMID: 7644764.


443: Shahin M, Schuppan D, Waldherr R, Savolainen ER, Zalpur F, Rahman HM, el
Sahly AM, Abdel Razek SM, el Ruby O, Seitz HK. Circulating enzyme activities of
collagen turnover and undulin in patients with various degrees of schistosomiasis
and alcoholic liver cirrhosis. Hepatogastroenterology. 1995 Feb;42(1):22-6.
PubMed PMID: 7782029.


444: Schnittger S, Herbst H, Schuppan D, Dannenberg C, Bauer M, Fonatsch C.
Localization of the undulin gene (UND) to human chromosome band 8q23. Cytogenet
Cell Genet. 1995;68(3-4):233-4. PubMed PMID: 7842743.


445: Milani S, Herbst H, Schuppan D, Grappone C, Heinrichs OE. Cellular sources
of extracellular matrix proteins in normal and fibrotic liver. Studies of gene
expression by in situ hybridization. J Hepatol. 1995;22(2 Suppl):71-6. Review.
PubMed PMID: 7665853.


446: Schuppan D, Stölzel U, Oesterling C, Somasundaram R. Serum assays for liver
fibrosis. J Hepatol. 1995;22(2 Suppl):82-8. Review. PubMed PMID: 7545196.


447: Herbst H, Schuppan D, Milani S. [Fibrogenesis and fibrolysis in the liver].
Verh Dtsch Ges Pathol. 1995;79:15-27. Review. German. PubMed PMID: 8600680.


448: Schmidt-Westhausen A, Becker J, Schuppan D, Burkhardt A, Reichart PA.
Odontogenic myxoma--characterisation of the extracellular matrix (ECM) of the
tumour stroma. Eur J Cancer B Oral Oncol. 1994 Nov;30B(6):377-80. PubMed PMID:
7536506.


449: Milani S, Grappone C, Pellegrini G, Schuppan D, Herbst H, Calabrò A, Casini
A, Pinzani M, Surrenti C. Undulin RNA and protein expression in normal and
fibrotic human liver. Hepatology. 1994 Oct;20(4 Pt 1):908-16. PubMed PMID:
7523266.


450: Reichart PA, van Wyk CW, Becker J, Schuppan D. Distribution of procollagen
type III, collagen type VI and tenascin in oral submucous fibrosis (OSF). J Oral
Pathol Med. 1994 Oct;23(9):394-8. PubMed PMID: 7529836.


451: Schuppan D, Somasundaram R, Dieterich W, Ehnis T, Bauer M. The extracellular
matrix in cellular proliferation and differentiation. Ann N Y Acad Sci. 1994 Sep
15;733:87-102. Review. PubMed PMID: 7978906.


452: Schuppan D, Rühl M. Matrix in signal transduction and growth factor
modulation. Braz J Med Biol Res. 1994 Sep;27(9):2125-41. Review. PubMed PMID:
7787796.


453: Schaberg T, Orzechowski K, Oesterling C, Lode H, Schuppan D. Simultaneous
measurement of collagen type-VI-related antigen and procollagen
type-III-N-propeptide levels in bronchoalveolar lavage. Eur Respir J. 1994
Jul;7(7):1221-6. PubMed PMID: 7925898.


454: Casini A, Ceni E, Salzano R, Schuppan D, Milani S, Pellegrini G, Surrenti C.
Regulation of undulin synthesis and gene expression in human fat-storing cells by
acetaldehyde and transforming growth factor-beta 1: comparison with fibronectin.
Biochem Biophys Res Commun. 1994 Mar 15;199(2):1019-26. PubMed PMID: 8135774.


455: Milani S, Herbst H, Schuppan D, Grappone C, Pellegrini G, Pinzani M, Casini
A, Calabró A, Ciancio G, Stefanini F, et al. Differential expression of
matrix-metalloproteinase-1 and -2 genes in normal and fibrotic human liver. Am J
Pathol. 1994 Mar;144(3):528-37. PubMed PMID: 8129038; PubMed Central PMCID:
PMC1887080.


456: Ballardini G, Groff P, Badiali de Giorgi L, Schuppan D, Bianchi FB. Ito cell
heterogeneity: desmin-negative Ito cells in normal rat liver. Hepatology. 1994
Feb;19(2):440-6. PubMed PMID: 7507464.


457: Casini A, Ceni E, Salzano R, Milani S, Schuppan D, Surrenti C. Acetaldehyde
regulates the gene expression of matrix-metalloproteinase-1 and -2 in human
fat-storing cells. Life Sci. 1994;55(17):1311-6. PubMed PMID: 7934638.


458: Rasmussen LH, Garbarsch C, Schuppan D, Moe D, Hørslev-Pedersen K, Gottrup F,
Steenfos H. Influence of human growth hormone on granulation tissue formation,
collagen deposition, and the aminoterminal propeptide of collagen type III in
wound chambers in rats. Wound Repair Regen. 1994 Jan;2(1):31-6. PubMed PMID:
17168909.


459: Schultka R, Göpel C, Schuppan D, Schmidt T. Age-dependent changes of the
immunohistochemical distribution of various collagen types and structural
glycoproteins in the human uterine tube. Acta Histochem. 1993 Dec;95(2):139-53.
PubMed PMID: 8135086.


460: Becker J, Schuppan D, Müller S. Immunohistochemical distribution of
collagens type I, III, IV and VI, of undulin and of tenascin in oral fibrous
hyperplasia. J Oral Pathol Med. 1993 Nov;22(10):463-7. PubMed PMID: 7510338.


461: Paulus W, Baur I, Schuppan D, Roggendorf W. Characterization of integrin
receptors in normal and neoplastic human brain. Am J Pathol. 1993
Jul;143(1):154-63. PubMed PMID: 8317546; PubMed Central PMCID: PMC1886949.


462: Jensen LT, Garbarsch C, Hørslev-Petersen K, Schuppan D, Kim K, Lorenzen I.
Collagen metabolism during wound healing in rats. The aminoterminal propeptide of
type III procollagen in serum and wound fluid in relation to formation of
granulation tissue. APMIS. 1993 Jul;101(7):557-64. PubMed PMID: 8398096.


463: Casini A, Pinzani M, Milani S, Grappone C, Galli G, Jezequel AM, Schuppan D,
Rotella CM, Surrenti C. Regulation of extracellular matrix synthesis by
transforming growth factor beta 1 in human fat-storing cells. Gastroenterology.
1993 Jul;105(1):245-53. PubMed PMID: 8514041.


464: Matthes H, Stallmach A, Matthes B, Herbst H, Schuppan D, Riecken EO.
[Indications for different collagen metabolism in Crohn disease and ulcerative
colitis]. Med Klin (Munich). 1993 Apr 15;88(4):185-92. German. PubMed PMID:
8492773.


465: Zhang X, Schuppan D, Becker J, Reichart P, Gelderblom HR. Distribution of
undulin, tenascin, and fibronectin in the human periodontal ligament and
cementum: comparative immunoelectron microscopy with ultra-thin cryosections. J
Histochem Cytochem. 1993 Feb;41(2):245-51. PubMed PMID: 7678270.


466: Rotella CM, Galli G, Casini A, Bianchi S, Mannucci E, Cresci B, Schuppan D,
Conti A, Brandi ML. Release of extracellular matrix components by bovine bone
endothelial cells in continuous culture. Biochem Biophys Res Commun. 1993 Jan
29;190(2):502-8. PubMed PMID: 8427593.


467: Keller F, Dingeldein K, Ser YL, Schuppan D. Propeptide levels of procollagen
type IV (NC1) and III (PIIINP) in patients undergoing haemodialysis. Int Urol
Nephrol. 1993;25(3):305-8. PubMed PMID: 8225832.


468: Klingel R, Ramadori G, Schuppan D, Knittel T, Meyer zum Büschenfelde KH,
Köhler H. Coexpression of extracellular matrix glycoproteins undulin and tenascin
in human autosomal dominant polycystic kidney disease. Nephron. 1993;65(1):111-8.
PubMed PMID: 7692313.


469: Knittel T, Odenthal M, Schuppan D, Schwögler S, Just M, Meyer zum
Büschenfelde KH, Ramadori G. Synthesis of undulin by rat liver fat-storing cells:
comparison with fibronectin and tenascin. Exp Cell Res. 1992 Dec;203(2):312-20.
PubMed PMID: 1281108.


470: Knittel T, Armbrust T, Schwögler S, Schuppan D, Ramadori G. Distribution and
cellular origin of undulin in rat liver. Lab Invest. 1992 Dec;67(6):779-87.
PubMed PMID: 1281245.


471: Griffiths MR, Shepherd M, Ferrier R, Schuppan D, James OF, Burt AD. Light
microscopic and ultrastructural distribution of type VI collagen in human liver:
alterations in chronic biliary disease. Histopathology. 1992 Oct;21(4):335-44.
PubMed PMID: 1398536.


472: Stallmach A, Schuppan D, Riese HH, Matthes H, Riecken EO. Increased collagen
type III synthesis by fibroblasts isolated from strictures of patients with
Crohn's disease. Gastroenterology. 1992 Jun;102(6):1920-9. PubMed PMID: 1587410.


473: Schuppan D. Vitamin A and liver fibrosis: cure or villain? J Lab Clin Med.
1992 Jun;119(6):590-1. Review. PubMed PMID: 1593206.


474: Knittel T, Schuppan D, Meyer zum Büschenfelde KH, Ramadori G. Differential
expression of collagen types I, III, and IV by fat-storing (Ito) cells in vitro.
Gastroenterology. 1992 May;102(5):1724-35. PubMed PMID: 1373696.


475: Shahin M, Schuppan D, Waldherr R, Risteli J, Risteli L, Savolainen ER,
Oesterling C, Abdel Rahman HM, el Sahly AM, Abdel Razek SM, et al. Serum
procollagen peptides and collagen type VI for the assessment of activity and
degree of hepatic fibrosis in schistosomiasis and alcoholic liver disease.
Hepatology. 1992 Apr;15(4):637-44. PubMed PMID: 1551641.


476: Becker J, Reichart PA, Schuppan D, Philipsen HP. Ectomesenchyme of
ameloblastic fibroma reveals a characteristic distribution of extracellular
matrix proteins. J Oral Pathol Med. 1992 Apr;21(4):156-9. Review. PubMed PMID:
1602407.


477: Keller F, Lyreal Ser Y, Schuppan D. Raised concentrations of the carboxy
terminal propeptide of type IV (basement membrane) procollagen (NC1) in serum and
urine of patients with glomerulonephritis. Eur J Clin Invest. 1992
Mar;22(3):175-81. PubMed PMID: 1582442.


478: Loréal O, Clément B, Schuppan D, Rescan PY, Rissel M, Guillouzo A.
Distribution and cellular origin of collagen VI during development and in
cirrhosis. Gastroenterology. 1992 Mar;102(3):980-7. PubMed PMID: 1537534.


479: Schuppan D. [Connective tissue polypeptides in serum: new parameters of
connective tissue synthesis and degradation in liver fibrosis]. Z Gastroenterol.
1992 Mar;30 Suppl 1:29-34. Review. German. PubMed PMID: 1449013.


480: Herbst H, Milani S, Heinrichs O, Schuppan D. [Pathomorphology of acute and
chronic stages of CCl4-induced liver fibrosis: immunohistochemical and in situ
hybridization studies]. Z Gastroenterol. 1992 Mar;30 Suppl 1:21-8. German. PubMed
PMID: 1449012.


481: Matthes H, Herbst H, Schuppan D, Stallmach A, Milani S, Stein H, Riecken EO.
Cellular localization of procollagen gene transcripts in inflammatory bowel
diseases. Gastroenterology. 1992 Feb;102(2):431-42. PubMed PMID: 1732114.


482: Stallmach A, Rosewicz S, Kaiser A, Matthes H, Schuppan D, Riecken EO.
Laminin binding in membranes of a rat pancreatic acinar cell line are targets for
glucocorticoids. Gastroenterology. 1992 Jan;102(1):237-47. PubMed PMID: 1530783.


483: Milani S, Herbst H, Schuppan D, Stein H, Surrenti C. Transforming growth
factors beta 1 and beta 2 are differentially expressed in fibrotic liver disease.
Am J Pathol. 1991 Dec;139(6):1221-9. PubMed PMID: 1750499; PubMed Central PMCID:
PMC1886459.


484: Hayasaka A, Koch J, Schuppan D, Maddrey WC, Hahn EG. The serum
concentrations of the aminoterminal propeptide of procollagen type III and the
hepatic content of mRNA for the alpha 1 chain of procollagen type III in carbon
tetrachloride-induced rat liver fibrogenesis. J Hepatol. 1991 Nov;13(3):328-38.
PubMed PMID: 1725528.


485: Just M, Herbst H, Hummel M, Dürkop H, Tripier D, Stein H, Schuppan D.
Undulin is a novel member of the fibronectin-tenascin family of extracellular
matrix glycoproteins. J Biol Chem. 1991 Sep 15;266(26):17326-32. PubMed PMID:
1716629.


486: Herbst H, Milani S, Schuppan D, Stein H. Temporal and spatial patterns of
proto-oncogene expression at early stages of toxic liver injury in the rat. Lab
Invest. 1991 Sep;65(3):324-33. PubMed PMID: 1890812.


487: Rabanus JP, Gelderblom HR, Schuppan D, Becker J. Distribution of collagens
type V and VI in the normal human alveolar mucosa: an immunoelectronmicroscopic
study using ultrathin frozen sections. J Periodontal Res. 1991 May;26(3 Pt
1):138-43. PubMed PMID: 1830615.


488: Stallmach A, Riese HH, Schuppan D, Bornhöft G, Stein H, Riecken EO.
Identification of different laminin binding proteins in basolateral cell
membranes of human colorectal carcinomas and normal colonic mucosa. Gut. 1991
Mar;32(3):282-6. PubMed PMID: 2013422; PubMed Central PMCID: PMC1378835.


489: Schuppan D. Connective tissue polypeptides in serum as parameters to monitor
antifibrotic treatment in hepatic fibrogenesis. J Hepatol. 1991;13 Suppl
3:S17-25. Review. PubMed PMID: 1815006.


490: Becker J, Schuppan D, Rabanus JP, Rauch R, Niechoy U, Gelderblom HR.
Immunoelectron microscopic localization of collagens type I, V, VI and of
procollagen type III in human periodontal ligament and cementum. J Histochem
Cytochem. 1991 Jan;39(1):103-10. PubMed PMID: 1983870.


491: Matthes H, Herbst H, Schuppan D, Stallmach A, Milani S, Stein H, Riecken EO.
[Distribution of procollagen transcripts in chronic inflammatory bowel diseases
using in situ hybridization]. Verh Dtsch Ges Inn Med. 1991;97:12-7. German.
PubMed PMID: 1808876.


492: Becker J, Schuppan D, Rabanus JP, Gelderblom HR, Reichart P. Immunoelectron
microscopy shows an atypical pattern and a quantitative shift of collagens type
I, III and VI in oral Kaposi's sarcoma of AIDS. Virchows Arch A Pathol Anat
Histopathol. 1991;419(3):237-44. PubMed PMID: 1926765.


493: Herbst H, Heinrichs O, Schuppan D, Milani S, Stein H. Temporal and spatial
patterns of transin/stromelysin RNA expression following toxic injury in rat
liver. Virchows Arch B Cell Pathol Incl Mol Pathol. 1991;60(5):295-300. PubMed
PMID: 1685036.


494: Geerts A, Schuppan D, Lazeroms S, De Zanger R, Wisse E. Collagen type I and
III occur together in hybrid fibrils in the space of Disse of normal rat liver.
Hepatology. 1990 Aug;12(2):233-41. PubMed PMID: 2391065.


495: Milani S, Herbst H, Schuppan D, Surrenti C, Riecken EO, Stein H. Cellular
localization of type I III and IV procollagen gene transcripts in normal and
fibrotic human liver. Am J Pathol. 1990 Jul;137(1):59-70. PubMed PMID: 2372043;
PubMed Central PMCID: PMC1877702.


496: Schuppan D, Cantaluppi MC, Becker J, Veit A, Bunte T, Troyer D, Schuppan F,
Schmid M, Ackermann R, Hahn EG. Undulin, an extracellular matrix glycoprotein
associated with collagen fibrils. J Biol Chem. 1990 May 25;265(15):8823-32.
PubMed PMID: 2187872.


497: Danne T, Poulsom R, Schuppan D, Prockop DJ, Boot-Handford RP.
Streptozotocin-diabetes but not galactose-feeding increases the serum
concentration of type IV collagen antigens in rats. Diabetes Res. 1990
May;14(1):1-4. PubMed PMID: 2134660.


498: Stallmach A, Schuppan D, Riecken EO. [The significance of the extracellular
matrix for carcinogenesis in the intestinal tract]. Dtsch Med Wochenschr. 1990
Mar 23;115(12):467-72. Review. German. PubMed PMID: 2180668.


499: Schuppan D. Structure of the extracellular matrix in normal and fibrotic
liver: collagens and glycoproteins. Semin Liver Dis. 1990 Feb;10(1):1-10. Review.
PubMed PMID: 2186485.


500: Schuppan D, Riecken EO. Molecules of the extracellular matrix: potential
role of collagens and glycoproteins in intestinal adaptation. Digestion. 1990;46
Suppl 2:2-11. Review. PubMed PMID: 2262053.


501: Reichart P, van den Berghe P, Becker J, Schuppan D, Hausamen JE.
[Significance of epithelial-mesenchyme interactions in microvascular pedicled
small intestine transplants replacing oral mucosa]. Fortschr Kiefer Gesichtschir.
1990;35:63-6. German. PubMed PMID: 1695601.


502: Milani S, Herbst H, Schuppan D, Kim KY, Riecken EO, Stein H. Procollagen
expression by nonparenchymal rat liver cells in experimental biliary fibrosis.
Gastroenterology. 1990 Jan;98(1):175-84. PubMed PMID: 2293576.


503: Stallmach A, Schuppan D, Dax J, Hanski C, Riecken EO. Identification of
laminin binding proteins in cell membranes of a human colon adenocarcinoma cell
line. Gut. 1990 Jan;31(1):70-6. PubMed PMID: 2138583; PubMed Central PMCID:
PMC1378343.


504: Burt AD, Griffiths MR, Schuppan D, Voss B, MacSween RN. Ultrastructural
localization of extracellular matrix proteins in liver biopsies using
ultracryomicrotomy and immuno-gold labelling. Histopathology. 1990
Jan;16(1):53-8. PubMed PMID: 2307416.


505: Hayasaka A, Schuppan D, Ohnishi K, Okuda K, Hahn EG. Serum concentrations of
the carboxyterminal cross-linking domain of procollagen type IV (NC1) and the
aminoterminal propeptide of procollagen type III (PIIIP) in chronic liver
disease. J Hepatol. 1990 Jan;10(1):17-22. PubMed PMID: 2307825.


506: Ruwart MJ, Wilkinson KF, Rush BD, Vidmar TJ, Peters KM, Henley KS, Appelman
HD, Kim KY, Schuppan D, Hahn EG. The integrated value of serum procollagen III
peptide over time predicts hepatic hydroxyproline content and stainable collagen
in a model of dietary cirrhosis in the rat. Hepatology. 1989 Nov;10(5):801-6.
PubMed PMID: 2807158.


507: Milani S, Herbst H, Schuppan D, Hahn EG, Stein H. In situ hybridization for
procollagen types I, III and IV mRNA in normal and fibrotic rat liver: evidence
for predominant expression in nonparenchymal liver cells. Hepatology. 1989
Jul;10(1):84-92. PubMed PMID: 2737606.


508: Milani S, Herbst H, Schuppan D, Riecken EO, Stein H. Cellular localization
of laminin gene transcripts in normal and fibrotic human liver. Am J Pathol. 1989
Jun;134(6):1175-82. PubMed PMID: 2474253; PubMed Central PMCID: PMC1879936.


509: Paulus W, Peiffer J, Roggendorf W, Schuppan D. Meningio-angiomatosis. Pathol
Res Pract. 1989 Apr;184(4):446-54. Review. PubMed PMID: 2498857.


510: Danne T, Grüters A, Schuppan D, Quantas N, Enders I, Weber B. Relationship
of procollagen type III propeptide-related antigens in serum to somatic growth in
healthy children and patients with growth disorders. J Pediatr. 1989
Feb;114(2):257-60. PubMed PMID: 2915284.


511: Milani S, Herbst H, Schuppan D, Niedobitek G, Kim KY, Stein H. Vimentin
expression of newly formed rat bile duct epithelial cells in secondary biliary
fibrosis. Virchows Arch A Pathol Anat Histopathol. 1989;415(3):237-42. PubMed
PMID: 2474887.


512: Schuppan D, Hahn EG, Riecken EO. [Changes in connective tissue metabolism in
alcohol-induced liver fibrosis]. Z Gastroenterol. 1988 Oct;26 Suppl 3:28-38.
Review. German. PubMed PMID: 3062941.


513: Hørslev-Petersen K, Kim KY, Pedersen LR, Bentsen KD, Uldbjerg N, Oxlund H,
Garbarsch C, Hahn EG, Schuppan D, Lorenzen I. Serum aminoterminal type III
procollagen peptide. Relation to biosynthesis of collagen type III in
experimentally induced granulation tissue in rats. APMIS. 1988 Sep;96(9):793-804.
PubMed PMID: 3048338.


514: Hørslev-Petersen K, Pedersen LR, Bentsen KD, Brocks D, Garbarsch C, Kim KY,
Hahn EG, Schuppan D, Lorenzen I. Collagen type IV and procollagen type III during
granulation tissue formation: a serological, biochemical, immunohistochemical and
morphometrical study on the viscose cellulose sponge rat model. Eur J Clin
Invest. 1988 Aug;18(4):352-9. PubMed PMID: 3139420.


515: Caselitz J, Schmitt P, Seifert G, Wustrow J, Schuppan D. Basal membrane
associated substances in human salivary glands and salivary gland tumours. Pathol
Res Pract. 1988 Aug;183(4):386-94. PubMed PMID: 2847123.


516: Roggendorf W, Opitz H, Schuppan D. Altered expression of collagen type VI in
brain vessels of patients with chronic hypertension. A comparison with the
distribution of collagen IV and procollagen III. Acta Neuropathol.
1988;77(1):55-60. PubMed PMID: 3239376.


517: Langford-Kuntz A, Becker J, Schuppan D, Gelderblom H, Pohle HD, Reichart P.
[Clinical, morphologic and immunohistochemical studies of oral Kaposi sarcoma
(AIDS)]. Fortschr Kiefer Gesichtschir. 1988;33:58-61. German. PubMed PMID:
3165935.


518: Keller F, Rehbein C, Schwarz A, Fleck M, Hayasaka A, Schuppan D, Offermann
G, Hahn EG. Increased procollagen III production in patients with kidney disease.
Nephron. 1988;50(4):332-7. PubMed PMID: 3237274.


519: Paulus W, Roggendorf W, Schuppan D. Immunohistochemical investigation of
collagen subtypes in human glioblastomas. Virchows Arch A Pathol Anat
Histopathol. 1988;413(4):325-32. PubMed PMID: 3140477.


520: Hahn U, Cho A, Schuppan D, Hahn EG, Merker HJ, Riecken EO. Intestinal
epithelial cells preferentially attach to a biomatrix derived from human
intestinal mucosa. Gut. 1987;28 Suppl:153-8. PubMed PMID: 3692302; PubMed Central
PMCID: PMC1434539.


521: Hahn U, Schuppan D, Hahn EG, Merker HJ, Riecken EO. Intestinal cells produce
basement membrane proteins in vitro. Gut. 1987;28 Suppl:143-51. PubMed PMID:
3692300; PubMed Central PMCID: PMC1434580.


522: Becker J, Schuppan D, Reichart P. The extracellular matrix in oral Kaposi
sarcoma (AIDS): the immunohistochemical distribution of collagens type IV, V, VI,
of procollagens type I and III, of laminin and of undulin. Virchows Arch A Pathol
Anat Histopathol. 1987;412(2):161-8. PubMed PMID: 3122416.


523: Becker J, Schuppan D, Benzian H, Bals T, Hahn EG, Cantaluppi C, Reichart P.
Immunohistochemical distribution of collagens types IV, V, and VI and of
pro-collagens types I and III in human alveolar bone and dentine. J Histochem
Cytochem. 1986 Nov;34(11):1417-29. PubMed PMID: 3772076.


524: Harrison LI, Schuppan D, Rohlfing SR, Hansen AR, Gerster JF, Hansen CS, Funk
ML, Ober RE. Disposition of radiolabeled flumequine in rat and dog. Drug Metab
Dispos. 1986 Sep-Oct;14(5):555-8. PubMed PMID: 2876861.


525: Becker J, Schuppan D, Albert G, Reichart P, Hahn EG. [The distribution of
the basal membrane constituents of collagen type IV and laminin in oral squamous
cell carcinomas]. Dtsch Z Mund Kiefer Gesichtschir. 1986 Jul-Aug;10(4):278-82.
German. PubMed PMID: 3482023.


526: Schuppan D, Besser M, Schwarting R, Hahn EG. Radioimmunoassay for the
carboxy-terminal cross-linking domain of type IV (basement membrane) procollagen
in body fluids. Characterization and application to collagen type IV metabolism
in fibrotic liver disease. J Clin Invest. 1986 Jul;78(1):241-8. PubMed PMID:
3722378; PubMed Central PMCID: PMC329555.


527: Schwarz U, Schuppan D, Oberbäumer I, Glanville RW, Deutzmann R, Timpl R,
Kühn K. Structure of mouse type IV collagen. Amino-acid sequence of the
C-terminal 511-residue-long triple-helical segment of the alpha 2(IV) chain and
its comparison with the alpha 1(IV) chain. Eur J Biochem. 1986 May
15;157(1):49-56. PubMed PMID: 3011432.


528: Becker J, Schuppan D, Hahn EG, Albert G, Reichart P. The immunohistochemical
distribution of collagens type IV, V, VI and of laminin in the human oral mucosa.
Arch Oral Biol. 1986;31(3):179-86. PubMed PMID: 3521555.


529: Schuppan D, Becker J, Boehm H, Hahn EG. Immunofluorescent localization of
type-V collagen as a fibrillar component of the interstitial connective tissue of
human oral mucosa, artery and liver. Cell Tissue Res. 1986;243(3):535-43. PubMed
PMID: 3513959.


530: Geerts A, Geuze HJ, Slot JW, Voss B, Schuppan D, Schellinck P, Wisse E.
Immunogold localization of procollagen III, fibronectin and heparan sulfate
proteoglycan on ultrathin frozen sections of the normal rat liver.
Histochemistry. 1986;84(4-6):355-62. PubMed PMID: 2941396.


531: Schuppan D, Dumont JM, Kim KY, Hennings G, Hahn EG. Serum concentration of
the aminoterminal procollagen type III peptide in the rat reflects early
formation of connective tissue in experimental liver cirrhosis. J Hepatol.
1986;3(1):27-37. PubMed PMID: 3745883.


532: Schuppan D, Rühlmann T, Hahn EG. Radioimmunoassay for human type VI collagen
and its application to tissue and body fluids. Anal Biochem. 1985 Aug
15;149(1):238-47. PubMed PMID: 4073480.


533: Schuppan D, Harrison LI, Rohlfing SR, Miller HL, Funk ML, Hansen CS, Ober
RE. Plasma and urine levels of flumequine and 7-hydroxyflumequine following
single and multiple oral dosing. J Antimicrob Chemother. 1985 Mar;15(3):337-43.
PubMed PMID: 3997708.


534: Schuppan D, Glanville RW, Timpl R, Dixit SN, Kang AH. Sequence comparison of
pepsin-resistant segments of basement-membrane collagen alpha 1(IV) chains from
bovine lens capsule and mouse tumour. Biochem J. 1984 May 15;220(1):227-33.
PubMed PMID: 6430279; PubMed Central PMCID: PMC1153614.


535: Harrison LI, Schuppan D, Rohlfing SR, Hansen AR, Hansen CS, Funk ML, Collins
SH, Ober RE. Determination of flumequine and a hydroxy metabolite in biological
fluids by high-pressure liquid chromatographic, fluorometric, and microbiological
methods. Antimicrob Agents Chemother. 1984 Mar;25(3):301-5. PubMed PMID: 6372680;
PubMed Central PMCID: PMC185504.


536: Walker SR, Schuetz E, Schuppan D, Gelzer J. A comparative retrospective
analysis of data from short- and long-term animal toxicity studies on 40
pharmaceutical compounds. Arch Toxicol Suppl. 1984;7:485-7. PubMed PMID: 6596020.


537: Kaumeier HS, Kehrhahn OH, Neugebauer G, Schuppan D, Schwarz JA, Staib AH. A
cross-over study of oral and intravenous administration of theophylline in male
volunteers. Absolute bioavailability of theophylline tablets.
Arzneimittelforschung. 1984;34(1):92-5. PubMed PMID: 6538428.


538: Kaumeier HS, Kehrhahn OH, Neugebauer G, Schuppan D, Schwarz JA, Staib AH. A
crossover study after oral and intravenous administration of theophylline in male
volunteers (absolute bioavailability of Afonilum tablets). Int J Clin Pharmacol
Ther Toxicol. 1983 Jul;21(7):339-45. PubMed PMID: 6885204.


539: Frömming KH, Schwabe L, Staib AH, Rietbrock N, Lassmann A, Molz KH, Schuppan
D, Siebert-Weigel M, Voegele D. [Release, absorption and elimination of
theophylline from fast and slowly released oral formulations].
Arzneimittelforschung. 1983;33(3):446-52. German. PubMed PMID: 6683521.


540: Bass R, Günzel P, Henschler D, König J, Lorke D, Neubert D, Schütz E,
Schuppan D, Zbinden G. [The LD50 in comparison with acute toxicity. A critical
evaluation of the present method]. Arzneimittelforschung. 1983;33(1):81-3.
German. PubMed PMID: 6681973.


541: Schuppan D, Glanville RW, Timpl R. Covalent structure of mouse type-IV
collagen. Isolation, order and partial amino-acid sequence of cyanogen-bromide
and tryptic peptides of pepsin fragment P1 from the alpha 1(IV) chain. Eur J
Biochem. 1982 Apr;123(3):505-12. PubMed PMID: 6804236.


542: Schuppan D, Molz KH, Staib AH, Rietbrock N. Bioavailability of theophylline
from a sustained-release aminophylline formulation (Euphyllin retard
tablets)--plasma levels after single and multiple oral doses. Int J Clin
Pharmacol Ther Toxicol. 1981 May;19(5):223-7. PubMed PMID: 7251238.


543: Mondorf AW, Stephan W, Uthemann H, Schuppan D, Lissner R. A clinical study
of the tolerance and safety of a beta-propiolactone-treated immunoglobulin.
Arzneimittelforschung. 1981;31(11):1928-30. PubMed PMID: 6797445.


544: Risteli J, Schuppan D, Glanville RW, Timpl R. Immunochemical distinction
between two different chains of type IV collagen. Biochem J. 1980 Nov
1;191(2):517-22. PubMed PMID: 6165353; PubMed Central PMCID: PMC1162242.


545: Staib AH, Schuppan D, Lissner R, Zilly W, von Bomhard G, Richter E.
Pharmacokinetics and metabolism of theophylline in patients with liver diseases.
Int J Clin Pharmacol Ther Toxicol. 1980 Nov;18(11):500-2. PubMed PMID: 7203726.


546: Schuppan D, Timpl R, Glanville RW. Discontinuities in the triple helical
sequence Gly-X-Y of basement membrane (type IV) collagen. FEBS Lett. 1980 Jun
30;115(2):297-300. PubMed PMID: 6772473.


547: Schuppan D, Schmidt I, Heller M. [Preliminary pharmacokinetics of
metoclopramide in humans. Plasma levels following a single oral and intravenous
dose (author's transl)]. Arzneimittelforschung. 1979;29(1):151-4. German. PubMed
PMID: 582108.


548: Schuppan D, Hansen CS, Ober RE. GLC determination of nanogram quantities of
a new analgesic, nefopam, in human plasma. J Pharm Sci. 1978 Dec;67(12):1720-3.
PubMed PMID: 722488.