Visual Universitätsmedizin Mainz

Publikationen

2020 - 2019 - 2018 - 2017 - 2016 - 2015 - 2014 - 2013 - 2012 - 2011 - 2010 - 2009-2005 - 2004-2000 - 1999-1990 -  vor 1990

2020

Chen W, Yang A, Jia J, Popov YV, Schuppan D, You H. Lysyl oxidase (LOX) family members: rationale and their potential as therapeutic targets for liver fibrosis.
Hepatology. 2020 Mar 16. doi: 10.1002/hep.31236. [Epub ahead of print] Review.PubMed PMID: 32176358.

Abe H, Schuppan D. β-arrestin: Dr Jekyll and Mr Hyde in NASH and fibrosis. J Hepatol. 2020 Feb 28. pii: S0168-8278(20)30057-X. doi:
10.1016/j.jhep.2020.01.016. [Epub ahead of print] PubMed PMID: 32122723.

Gore E, Bigaeva E, Oldenburger A, Jansen YJM, Schuppan D, Boersema M, Rippmann JF, Broermann A, Olinga P. Investigating fibrosis and inflammation in an ex vivo
NASH murine model. Am J Physiol Gastrointest Liver Physiol. 2020 Feb 1;318(2):G336-G351. doi: 10.1152/ajpgi.00209.2019. Epub 2020 Jan 6. PubMed PMID: 31905025.

Karsdal MA, Daniels SJ, Holm Nielsen S, Bager C, Rasmussen DGK, Loomba R,Surabattula R, Villesen IF, Luo Y, Shevell D, Gudmann NS, Nielsen MJ, George J,
Christian R, Leeming DJ, Schuppan D. Collagen biology and non-invasive biomarkers of liver fibrosis. Liver Int. 2020 Jan 29. doi: 10.1111/liv.14390. [Epub ahead of print] Review. PubMed PMID: 31997561.

Dropmann A, Dooley S, Dewidar B, Hammad S, Dediulia T, Werle J, Hartwig V, Ghafoory S, Woelfl S, Korhonen H, Janicot M, Wosikowski K, Itzel T, Teufel A,
Schuppan D, Stojanovic A, Cerwenka A, Nittka S, Piiper A, Gaiser T, Beraza N,Milkiewicz M, Milkiewicz P, Brain JG, Jones DEJ, Weiss TS, Zanger UM, Ebert M,
Meindl-Beinker NM. TGF-β2 silencing to target biliary-derived liver diseases.Gut. 2020 Jan 28. pii: gutjnl-2019-319091. doi: 10.1136/gutjnl-2019-319091. [Epub ahead of print] PubMed PMID: 31992593.

Wei G, An P, Vaid KA, Nasser I, Huang P, Tan L, Zhao S, Schuppan D, Popov YV. Comparison of murine steatohepatitis models identifies a dietary intervention
with robust fibrosis, ductular reaction, and rapid progression to cirrhosis andcancer. Am J Physiol Gastrointest Liver Physiol. 2020 Jan 1;318(1):G174-G188.
doi: 10.1152/ajpgi.00041.2019. Epub 2019 Oct 21. PubMed PMID: 31630534; PubMedCentral PMCID: PMC6985845.

Helmstädter J, Frenis K, Filippou K, Grill A, Dib M, Kalinovic S, Pawelke F,Kus K, Kröller-Schön S, Oelze M, Chlopicki S, Schuppan D, Wenzel P, Ruf W,
Drucker DJ, Münzel T, Daiber A, Steven S. Endothelial GLP-1 (Glucagon-LikePeptide-1) Receptor Mediates Cardiovascular Protection by Liraglutide In Mice
With Experimental Arterial Hypertension. Arterioscler Thromb Vasc Biol. 2020 Jan;40(1):145-158. doi: 10.1161/atv.0000615456.97862.30. Epub 2019 Nov 21. PubMed PMID: 31747801; PubMed Central PMCID: PMC6946108.

Bigaeva E, Gore E, Mutsaers HAM, Oosterhuis D, Kim YO, Schuppan D, Bank RA,Boersema M, Olinga P. Exploring organ-specific features of fibrogenesis using
murine precision-cut tissue slices. Biochim Biophys Acta Mol Basis Dis. 2020 Jan 1;1866(1):165582. doi: 10.1016/j.bbadis.2019.165582. Epub 2019 Oct 30. PubMed PMID: 31676376.

Karsdal MA, Detlefsen S, Daniels SJ, Nielsen MJ, Krag A, Schuppan D. Is the Total Amount as Important as Localization and Type of Collagen in Liver Fibrosis
Attributable to Steatohepatitis? Hepatology. 2020 Jan;71(1):346-351. doi:10.1002/hep.30969. Epub 2019 Dec 18. Review. PubMed PMID: 31553813.

Verdu EF, Schuppan D. The enemy within the gut: bacterial pathogens in celiacautoimmunity. Nat Struct Mol Biol. 2020 Jan;27(1):5-7. doi: 10.1038/s41594-019-0360-5. PubMed PMID: 31873302.

 

 

2019

Chapeau EA, Mandon E, Gill J, Romanet V, Ebel N, Powajbo V, Andraos-Rey R, Qian Z, Kininis M, Zumstein-Mecker S, Ito M, Hynes NE, Tiedt R, Hofmann F, Eshkind L, Bockamp E, Kinzel B, Mueller M, Murakami M, Baffert F, Radimerski T. A conditional inducible JAK2V617F transgenic mouse model reveals myeloproliferative disease that is reversible upon switching off transgene expression. PLoS One. 2019 Oct 10;14(10):e0221635. doi: 10.1371/journal.pone.0221635. eCollection 2019. PMID:31600213


Farrell G, Schattenberg JM, Leclercq I, Yeh MM, Goldin R, Teoh N, Schuppan D.
Mouse Models of Nonalcoholic Steatohepatitis: Toward Optimization of Their Relevance to Human Nonalcoholic Steatohepatitis. Hepatology. 2019 May;69(5):2241-2257. doi: 10.1002/hep.30333. Review. PubMed PMID: 30372785.

 

Dieterich W, Schuppan D, Schink M, Schwappacher R, Wirtz S, Agaimy A, Neurath MF, Zopf Y. Influence of low FODMAP and gluten-free diets on disease activity and intestinal microbiota in patients with non-celiac gluten sensitivity. Clin Nutr. 2019 Apr;38(2):697-707. doi: 10.1016/j.clnu.2018.03.017. Epub 2018 Apr 4. PubMed PMID: 29653862.


Terryberry J, Tuomi J, Perampalam S, Peloquin R, Brouwer E, Schuppan D, Guandalini S.
Diagnostic accuracy of a fully automated multiplex celiac disease antibody panel for serum and plasma. Clin Chem Lab Med. 2019 Mar 23. pii:/j/cclm.ahead-of-print/cclm-2019-0088/cclm-2019-0088.xml. doi:10.1515/cclm-2019-0088. [Epub ahead of print] PubMed PMID: 30903755.
 

Elli L, Ferretti F, Orlando S, Vecchi M, Monguzzi E, Roncoroni L, Schuppan D. Management of celiac disease in daily clinical practice. Eur J Intern Med. 2019 Mar;61:15-24. doi: 10.1016/j.ejim.2018.11.012. Epub 2018 Dec 5. Review. PubMed PMID: 30528262.


Zimmermann A, Darstein F, Hoppe-Lotichius M, Toenges G, Lautem A, Abel F, Schad A, Mittler J, Vollmar J, Grimm D, Lang H, Galle PR, Zimmermann T, Schuppan D.
Cirrhosis risk score of the donor organ predicts early fibrosis progression after liver transplantation. J Gastrointestin Liver Dis. 2019 Mar;28(1):53-61.doi: 10.15403/jgld.2014.1121.281.crr. PubMed PMID: 30851173.


Kazankov K, Jørgensen SMD, Thomsen KL, Møller HJ, Vilstrup H, George J, Schuppan D, Grønbæk H.
The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Nat Rev Gastroenterol Hepatol. 2019 Mar;16(3):145-159. doi: 10.1038/s41575-018-0082-x. Review. PubMed PMID: 30482910.

 

van Dijk F, Teekamp N, Post E, Schuppan D, Kim YO, Zuidema J, Steendam R, Klose MHM, Meier-Menches SM, Casini A, Horvatovich PL, Sijbrandi NJ, Frijlink HW,Hinrichs WLJ, Poelstra K, Beljaars L, Olinga P. The antifibrotic potential of a sustained release formulation of a PDGFβ-receptor targeted rho kinase inhibitor. J Control Release. 2019 Feb 28;296:250-257. doi: 10.1016/j.jconrel.2018.12.039. Epub 2019 Jan 22. PubMed PMID: 30682444.

 

Caminero A, McCarville JL, Zevallos VF, Pigrau M, Yu XB, Jury J, Galipeau HJ, Clarizio AV, Casqueiro J, Murray JA, Collins SM, Alaedini A, Bercik P, Schuppan D, Verdu EF. Lactobacilli Degrade Wheat Amylase Trypsin Inhibitors to Reduce Intestinal Dysfunction Induced by Immunogenic Wheat Proteins. Gastroenterology. 2019 Feb 22. pii: S0016-5085(19)30437-8. doi: 10.1053/j.gastro.2019.02.028. PubMed PMID: 30802444.

 

Pfanzagl B, Zevallos VF, Schuppan D, Pfragner R, Jensen-Jarolim E. Histamine causes influx via T-type voltage-gated calcium channels in an enterochromaffin tumor cell line: potential therapeutic target in adverse food reactions. Am J Physiol Gastrointest Liver Physiol. 2019 Feb 1;316(2):G291-G303. doi:10.1152/ajpgi.00261.2018. Epub 2018 Dec 12. PubMed PMID: 30540489.

 

Ziegler K, Neumann J, Liu F, Fröhlich-Nowoisky J, Cremer C, Saloga J,Reinmuth-Selzle K, Pöschl U, Schuppan D, Bellinghausen I, Lucas K. Nitration of Wheat Amylase Trypsin Inhibitors Increases Their Innate and Adaptive Immunostimulatory Potential in vitro. Front Immunol. 2019 Jan 21;9:3174. doi: 10.3389/fimmu.2018.03174. eCollection 2018. PubMed PMID: 30740114;

 

Karsdal MA, Hjuler ST, Luo Y, Rasmussen DGK, Nielsen MJ, Holm Nielsen S,Leeming DJ, Goodman Z, Arch RH, Patel K, Schuppan D. Assessment of liver fibrosis´progression and regression by a serological collagen turnover profile. Am J Physiol Gastrointest Liver Physiol. 2019 Jan 1;316(1):G25-G31. doi: 10.1152/ajpgi.00158.2018. Epub 2018 Aug 30. PubMed PMID: 30160980.

2018

Bellinghausen I, Weigmann B, Zevallos V, Maxeiner J, Reißig S, Waisman A,
Schuppan D, Saloga J.
Wheat amylase-trypsin inhibitors exacerbate intestinal and
airway allergic immune responses in humanized mice. J Allergy Clin Immunol. 2019
Jan;143(1):201-212.e4. doi: 10.1016/j.jaci.2018.02.041. Epub 2018 Mar 21. PubMed
PMID: 29574077.

 

Luther J, Yorgan TA, Rolvien T, Ulsamer L, Koehne T, Liao N, Keller D, Vollersen N, Teufel S, Neven M, Peters S, Schweizer M, Trumpp A, Rosigkeit S, Bockamp E, Mundlos S, Kornak U, Oheim R, Amling M, Schinke T, David JP. Wnt1 is an Lrp5-independent bone-anabolic Wnt ligand. Sci Transl Med. 2018 Nov 7;10(466). pii: eaau7137. doi: 10.1126/scitranslmed.aau7137.
PMID: 30404864


Kahaly GJ, Frommer L, Schuppan D.
Celiac disease and endocrine autoimmunity -
the genetic link. Autoimmun Rev. 2018 Dec;17(12):1169-1175. doi:
10.1016/j.autrev.2018.05.013. Epub 2018 Oct 12. Review. PubMed PMID: 30316996.


Schink A, Naumoska K, Kitanovski Z, Kampf CJ, Fröhlich-Nowoisky J, Thines E,
Pöschl U, Schuppan D, Lucas K.
Anti-inflammatory effects of cinnamon extract and
identification of active compounds influencing the TLR2 and TLR4 signaling
pathways. Food Funct. 2018 Nov 14;9(11):5950-5964. doi: 10.1039/c8fo01286e.
PubMed PMID: 30379176.

 

Labenz C, Huber Y, Kalliga E, Nagel M, Ruckes C, Straub BK, Galle PR, Wörns
MA, Anstee QM, Schuppan D, Schattenberg JM
. Predictors of advanced fibrosis in
non-cirrhotic non-alcoholic fatty liver disease in Germany. Aliment Pharmacol
Ther. 2018 Nov;48(10):1109-1116. doi: 10.1111/apt.14976. Epub 2018 Oct 4. PubMed
PMID: 30288767.


Schink A, Neumann J, Leifke AL, Ziegler K, Fröhlich-Nowoisky J, Cremer C,
Thines E, Weber B, Pöschl U, Schuppan D, Lucas K
. Screening of herbal extracts
for TLR2- and TLR4-dependent anti-inflammatory effects. PLoS One. 2018 Oct
11;13(10):e0203907. doi: 10.1371/journal.pone.0203907. eCollection 2018. PubMed
PMID: 30307962

 

Rosigkeit S, Meng M, Grunwitz C, Gomes P, Kreft A, Hayduk N, Heck R, Pickert
G, Ziegler K, Abassi Y, Röder J, Kaps L, Vascotto F, Beissert T, Witzel S, Kuhn
A, Diken M, Schuppan D, Sahin U, Haas H, Bockamp E.
Monitoring Translation
Activity of mRNA-Loaded Nanoparticles in Mice. Mol Pharm. 2018 Sep
4;15(9):3909-3919. doi: 10.1021/acs.molpharmaceut.8b00370. Epub 2018 Aug 9.
PubMed PMID: 30028629.


Ludvigsson JF, Ciacci C, Green PH, Kaukinen K, Korponay-Szabo IR, Kurppa K,
Murray JA, Lundin KEA, Maki MJ, Popp A, Reilly NR, Rodriguez-Herrera A, Sanders
DS, Schuppan D, Sleet S, Taavela J, Voorhees K, Walker MM, Leffler DA.
Outcome
measures in coeliac disease trials: the Tampere recommendations. Gut. 2018
Aug;67(8):1410-1424. doi: 10.1136/gutjnl-2017-314853. Epub 2018 Feb 13. PubMed
PMID: 29440464.


Schuppan D, Ashfaq-Khan M, Yang AT, Kim YO
. Liver fibrosis: Direct
antifibrotic agents and targeted therapies. Matrix Biol. 2018 Aug;68-69:435-451.
doi: 10.1016/j.matbio.2018.04.006. Epub 2018 Apr 12. Review. PubMed PMID:
29656147.


Hintermann E, Bayer M, Conti CB, Fuchs S, Fausther M, Leung PS, Aurrand-Lions
M, Taubert R, Pfeilschifter JM, Friedrich-Rust M, Schuppan D, Dranoff JA,
Gershwin ME, Manns MP, Imhof BA, Christen U.
Junctional adhesion molecules JAM-B
and JAM-C promote autoimmune-mediated liver fibrosis in mice. J Autoimmun. 2018
Jul;91:83-96. doi: 10.1016/j.jaut.2018.05.001. Epub 2018 May 9. PubMed PMID:
29753567.


Kahaly GJ, Frommer L, Schuppan D.
Celiac Disease and Glandular Autoimmunity.
Nutrients. 2018 Jun 25;10(7). pii: E814. doi: 10.3390/nu10070814. Review. PubMed
PMID: 29941778.

 

Hofmann SR, Laass MW, Fehrs A, Schuppan D, Zevallos VF, Salminger D, Mäbert
K, Hedrich CM.
IL10 promoter haplotypes may contribute to altered cytokine
expression and systemic inflammation in celiac disease. Clin Immunol. 2018
May;190:15-21. doi: 10.1016/j.clim.2018.02.010. Epub 2018 Feb 24. PubMed PMID:
29481982.


Zevallos VF, Raker VK, Maxeiner J, Scholtes P, Steinbrink K, Schuppan D.
Dietary wheat amylase trypsin inhibitors exacerbate murine allergic airway
inflammation. Eur J Nutr. 2018 Mar 29. doi: 10.1007/s00394-018-1681-6. [Epub
ahead of print] PubMed PMID: 29600329.

 

Foerster F, Hess M, Gerhold-Ay A, Marquardt JU, Becker D, Galle PR, Schuppan
D, Binder H, Bockamp E.
The immune contexture of hepatocellular carcinoma
predicts clinical outcome. Sci Rep. 2018 Mar 29;8(1):5351. doi:
10.1038/s41598-018-21937-2. PubMed PMID: 29599491.

 

Christensen CU, Glavind E, Thomsen KL, Kim YO, Heebøll S, Schuppan D,
Hamilton-Dutoit S, Würtz Heegaard C, Grønbæk H.
Niemann-Pick type C2 protein
supplementation in experimental non-alcoholic fatty liver disease. PLoS One. 2018
Mar 9;13(3):e0192728. doi: 10.1371/journal.pone.0192728. eCollection 2018. PubMed
PMID: 29522534.

 

Weng SY, Wang X, Vijayan S, Tang Y, Kim YO, Padberg K, Regen T, Molokanova O,
Chen T, Bopp T, Schild H, Brombacher F, Crosby JR, McCaleb ML, Waisman A, Bockamp
E, Schuppan D.
IL-4 Receptor Alpha Signaling through Macrophages Differentially
Regulates Liver Fibrosis Progression and Reversal. EBioMedicine. 2018
Mar;29:92-103. doi: 10.1016/j.ebiom.2018.01.028. Epub 2018 Feb 17. PubMed PMID:
29463471.

 

Molokanova O, Schönig K, Weng SY, Wang X, Bros M, Diken M, Ohngemach S,
Karsdal M, Strand D, Nikolaev A, Eshkind L, Schuppan D.
Inducible knockdown of
procollagen I protects mice from liver fibrosis and leads to dysregulated matrix
genes and attenuated inflammation. Matrix Biol. 2018 Mar;66:34-49. doi:
10.1016/j.matbio.2017.11.002. Epub 2017 Nov 6. PubMed PMID: 29122677.


Schuppan D, Surabattula R, Wang XY.
Determinants of fibrosis progression and
regression in NASH. J Hepatol. 2018 Feb;68(2):238-250. doi:
10.1016/j.jhep.2017.11.012. Epub 2017 Nov 14. Review. PubMed PMID: 29154966.


Stein J, Schulzke JD, Schuppan D.
[Drug therapy in coeliac disease - "from
bench to bedside"]. Z Gastroenterol. 2018 Feb;56(2):151-164. doi:
10.1055/s-0043-121345. Epub 2017 Nov 7. German. PubMed PMID: 29113008.

 

Lang-Yona N, Kunert AT, Vogel L, Kampf CJ, Bellinghausen I, Saloga J, Schink
A, Ziegler K, Lucas K, Schuppan D, Pöschl U, Weber B, Fröhlich-Nowoisky J.
Fresh
water, marine and terrestrial cyanobacteria display distinct allergen
characteristics. Sci Total Environ. 2018 Jan 15;612:767-774. doi:
10.1016/j.scitotenv.2017.08.069. Epub 2017 Sep 1. PubMed PMID: 28866404.

 

Wang X, Hausding M, Weng SY, Kim YO, Steven S, Klein T, Daiber A, Schuppan D.Gliptins Suppress Inflammatory Macrophage Activation to Mitigate Inflammation,
Fibrosis, Oxidative Stress, and Vascular Dysfunction in Models of Nonalcoholic
Steatohepatitis and Liver Fibrosis. Antioxid Redox Signal. 2018 Jan
10;28(2):87-109. doi: 10.1089/ars.2016.6953. Epub 2017 Jul 25. PubMed PMID:
28635324.

 

van Dijk F, Teekamp N, Beljaars L, Post E, Zuidema J, Steendam R, Kim YO,
Frijlink HW, Schuppan D, Poelstra K, Hinrichs WLJ, Olinga P.
Pharmacokinetics of
a sustained release formulation of PDGFβ-receptor directed carrier proteins to
target the fibrotic liver. J Control Release. 2018 Jan 10;269:258-265. doi:
10.1016/j.jconrel.2017.11.029. Epub 2017 Nov 21. PubMed PMID: 29170138.

2017

Foerster F, Boegel S, Heck R, Pickert G, Rüssel N, Rosigkeit S, Bros M, Strobl S, Kaps L, Aslam M, Diken M, Castle J, Sahin U, Tuettenberg A, Bockamp E, Schuppan D. Enhanced protection of C57 BL/6 vs Balb/c mice to melanoma liver metastasis is mediated by NK cells. Oncoimmunology. 2017 Dec 26;7(4):e1409929.
doi: 10.1080/2162402X.2017.1409929. eCollection 2018. PubMed PMID: 29632723.

 

Vollmar J, Lautem A, Closs E, Schuppan D, Kim YO, Grimm D, Marquardt JU,Fuchs P, Straub BK, Schad A, Gründemann D, Schattenberg JM, Gehrke N, Wörns MA, Baumgart J, Galle PR, Zimmermann T. Loss of organic cation transporter 3 (Oct3) leads to enhanced proliferation and hepatocarcinogenesis. Oncotarget. 2017 Dec 18;8(70):115667-115680. doi: 10.18632/oncotarget.23372. eCollection 2017 Dec 29. PubMed PMID: 29383190.


Hughey JJ, Ray BK, Lee AR, Voorhees KN, Kelly CP, Schuppan D.
Self-reported dietary adherence, disease-specific symptoms, and quality of life are associated with healthcare provider follow-up in celiac disease. BMC Gastroenterol. 2017 Dec 11;17(1):156. doi: 10.1186/s12876-017-0713-7. PubMed PMID: 29228908.


Catassi C, Alaedini A, Bojarski C, Bonaz B, Bouma G, Carroccio A, Castillejo G, De Magistris L, Dieterich W, Di Liberto D, Elli L, Fasano A, Hadjivassiliou M, Kurien M, Lionetti E, Mulder CJ, Rostami K, Sapone A, Scherf K, Schuppan D, Trott N, Volta U, Zevallos V, Zopf Y, Sanders DS.
The Overlapping Area of Non-Celiac Gluten Sensitivity (NCGS) and Wheat-Sensitive Irritable Bowel Syndrome (IBS): An Update. Nutrients. 2017 Nov 21;9(11). pii: E1268. doi: 10.3390/nu9111268. Review.PubMed PMID: 29160841; PubMed Central PMCID: PMC5707740.


Schupp J, Krebs FK, Zimmer N, Trzeciak E, Schuppan D, Tuettenberg A.
Targeting myeloid cells in the tumor sustaining microenvironment. Cell Immunol. 2017 Nov 2. pii: S0008-8749(17)30190-9. doi: 10.1016/j.cellimm.2017.10.013. [Epub ahead of print] Review. PubMed PMID: 29129292.


Karsdal MA, Nielsen SH, Leeming DJ, Langholm LL, Nielsen MJ, Manon-Jensen T, Siebuhr A, Gudmann NS, Rønnow S, Sand JM, Daniels SJ, Mortensen JH, Schuppan D.
The good and the bad collagens of fibrosis - Their role in signaling and organ function. Adv Drug Deliv Rev. 2017 Nov 1;121:43-56. doi: 10.1016/j.addr.2017.07.014. Epub 2017 Jul 21. Review. PubMed PMID: 28736303.


Isokuortti E, Zhou Y, Peltonen M, Bugianesi E, Clement K, Bonnefont-Rousselot D, Lacorte JM, Gastaldelli A, Schuppan D, Schattenberg JM, Hakkarainen A, Lundbom N, Jousilahti P, Männistö S, Keinänen-Kiukaanniemi S, Saltevo J, Anstee QM, Yki-Järvinen H.
Use of HOMA-IR to diagnose non-alcoholic fatty liver disease: a population-based and inter-laboratory study. Diabetologia. 2017 Oct;60(10):1873-1882. doi: 10.1007/s00125-017-4340-1. Epub 2017 Jun 29. PubMed PMID: 28660493.

 

Luangmonkong T, Suriguga S, Bigaeva E, Boersema M, Oosterhuis D, de Jong KP, Schuppan D, Mutsaers HAM, Olinga P. Evaluating the antifibrotic potency of galunisertib in a human ex vivo model of liver fibrosis. Br J Pharmacol. 2017 Sep;174(18):3107-3117. doi: 10.1111/bph.13945. Epub 2017 Aug 11. PubMed PMID: 28691737; PubMed Central PMCID: PMC5573419.

 

Ikenaga N, Peng ZW, Vaid KA, Liu SB, Yoshida S, Sverdlov DY, Mikels-Vigdal A, Smith V, Schuppan D, Popov YV. Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal. Gut. 2017 Sep;66(9):1697-1708. doi: 10.1136/gutjnl-2016-312473. Epub 2017 Jan 10. PubMed PMID: 28073888; PubMed Central PMCID: PMC5561383.


Chen T, Zhu L, Shi A, Ding L, Zhang X, Tan Z, Guo W, Yan W, Han M, Jia J, Luo X, Schuppan D, Ning Q.
Functional restoration of CD56(bright) NK cells facilitates immune control via IL-15 and NKG2D in patients under antiviral treatment for chronic hepatitis B. Hepatol Int. 2017 Sep;11(5):419-428. doi: 10.1007/s12072-017-9803-4. Epub 2017 Jun 20. PubMed PMID: 28639033; PubMed Central PMCID: PMC5606950.

 

Haeberle S, Raker V, Haub J, Kim YO, Weng SY, Yilmaz OK, Enk A, Steinbrink K, Schuppan D, Hadaschik EN. Regulatory T cell deficient scurfy mice exhibit a Th2/M2-like inflammatory response in the skin. J Dermatol Sci. 2017 Sep;87(3):285-291. doi: 10.1016/j.jdermsci.2017.07.001. Epub 2017 Jul 13. PubMed PMID: 28811075.


Raker V, Haub J, Stojanovic A, Cerwenka A, Schuppan D, Steinbrink K.
Early inflammatory players in cutanous fibrosis. J Dermatol Sci. 2017 Sep;87(3):228-235. doi: 10.1016/j.jdermsci.2017.06.009. Epub 2017 Jun 15. Review. PubMed PMID: 28655471.

 

Ackermann M, Kim YO, Wagner WL, Schuppan D, Valenzuela CD, Mentzer SJ, Kreuz S, Stiller D, Wollin L, Konerding MA. Effects of nintedanib on the microvascular
architecture in a lung fibrosis model. Angiogenesis. 2017 Aug;20(3):359-372. doi: 10.1007/s10456-017-9543-z. Epub 2017 Mar 10. PubMed PMID: 28283856.


Julich-Haertel H, Urban SK, Krawczyk M, Willms A, Jankowski K, Patkowski W, Kruk B, Krasnodębski M, Ligocka J, Schwab R, Richardsen I, Schaaf S, Klein A, Gehlert S, Sänger H, Casper M, Banales JM, Schuppan D, Milkiewicz P, Lammert F, Krawczyk M, Lukacs-Kornek V, Kornek M.
Cancer-associated circulating large extracellular vesicles in cholangiocarcinoma and hepatocellular carcinoma. J Hepatol. 2017 Aug;67(2):282-292. doi: 10.1016/j.jhep.2017.02.024. Epub 2017 Mar 6. PubMed PMID: 28267620.

 

Fleck AK, Schuppan D, Wiendl H, Klotz L. Gut-CNS-Axis as Possibility to Modulate Inflammatory Disease Activity-Implications for Multiple Sclerosis. Int J Mol Sci. 2017 Jul 14;18(7). pii: E1526. doi: 10.3390/ijms18071526. Review. PubMed PMID: 28708108; PubMed Central PMCID: PMC5536015.


Huber Y, Gehrke N, Biedenbach J, Helmig S, Simon P, Straub BK, Bergheim I, Huber T, Schuppan D, Galle PR, Wörns MA, Schuchmann M, Schattenberg JM.
Voluntary distance running prevents TNF-mediated liver injury in mice through alterations of the intrahepatic immune milieu. Cell Death Dis. 2017 Jun 22;8(6):e2893. doi: 10.1038/cddis.2017.266. PubMed PMID: 28640248; PubMed Central PMCID: PMC5520921.


Lackner C, Bataller R, Burt A, Miquel R, Schuppan D, Tiniakos D, Trauner M.
Fibrosis evaluation by transient elastography in alcoholic liver disease: Is the histological scoring system impacting cutoff values? Hepatology. 2017 May;65(5):1758-1761. doi: 10.1002/hep.29075. Epub 2017 Apr 3. PubMed PMID:
28120459.

 

Reinmuth-Selzle K, Kampf CJ, Lucas K, Lang-Yona N, Fröhlich-Nowoisky J, Shiraiwa M, Lakey PSJ, Lai S, Liu F, Kunert AT, Ziegler K, Shen F, Sgarbanti R, Weber B, Bellinghausen I, Saloga J, Weller MG, Duschl A, Schuppan D, Pöschl U. Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants. Environ Sci Technol. 2017 Apr 18;51(8):4119-4141. doi: 10.1021/acs.est.6b04908. Epub 2017 Apr 6. PubMed PMID: 28326768; PubMed Central PMCID: PMC5453620.

 

Zevallos VF, Raker V, Tenzer S, Jimenez-Calvente C, Ashfaq-Khan M, Rüssel N, Pickert G, Schild H, Steinbrink K, Schuppan D. Nutritional Wheat Amylase-Trypsin Inhibitors Promote Intestinal Inflammation via Activation of Myeloid Cells. Gastroenterology. 2017 Apr;152(5):1100-1113.e12. doi:
10.1053/j.gastro.2016.12.006. Epub 2016 Dec 16. PubMed PMID: 27993525.


Tian N, Faller L, Leffler DA, Kelly CP, Hansen J, Bosch JA, Wei G, Paster BJ,  Schuppan D, Helmerhorst EJ.
Salivary Gluten Degradation and Oral Microbial Profiles in Healthy Individuals and Celiac Disease Patients. Appl Environ Microbiol. 2017 Mar 2;83(6). pii: e03330-16. doi: 10.1128/AEM.03330-16. Print
2017 Mar 15. PubMed PMID: 28087531; PubMed Central PMCID: PMC5335528.

 

Tanwar S, Trembling PM, Hogan BJ, Srivastava A, Parkes J, Harris S, Grant P, Nastouli E, Ocker M, Wehr K, Herold C, Neureiter D, Schuppan D, Rosenberg WM.Noninvasive markers of liver fibrosis: on-treatment changes of serum markers predict the outcome of antifibrotic therapy. Eur J Gastroenterol Hepatol. 2017
Mar;29(3):289-296. doi: 10.1097/MEG.0000000000000789. PubMed PMID: 27906753.

 

Tanwar S, Trembling PM, Hogan BJ, Parkes J, Harris S, Grant P, Nastouli E, Ocker M, Wehr K, Herold C, Neureiter D, Schuppan D, Rosenberg WM. Biomarkers of Hepatic Fibrosis in Chronic Hepatitis C: A Comparison of 10 Biomarkers Using 2 Different Assays for Hyaluronic Acid. J Clin Gastroenterol. 2017
Mar;51(3):268-277. doi: 10.1097/MCG.0000000000000581. PubMed PMID: 27380461.

 

Leber N, Kaps L, Aslam M, Schupp J, Brose A, Schäffel D, Fischer K, Diken M, Strand D, Koynov K, Tuettenberg A, Nuhn L, Zentel R, Schuppan D. SiRNA-mediated in vivo gene knockdown by acid-degradable cationic nanohydrogel particles. J Control Release. 2017 Feb 28;248:10-23. doi: 1016/j.jconrel.2016.12.006. Epub 2016 Dec 9. PubMed PMID: 27940184.

 

Reiss-Pistilli ML, Schuppan D, Barroso MM, Assunção-Miranda I, Farias S, Lery L, Bauer M, Juliano L, Juliano MA, Coelho-Sampaio T. An extracellular proteasome releases endostatin from human collagen XVIII. Angiogenesis. 2017 Feb;20(1):125-137. doi: 10.1007/s10456-016-9533-6. Epub 2016 Dec 5. PubMed PMID: 27921229.

 

Cañete A, Comaills V, Prados I, Castro AM, Hammad S, Ybot-Gonzalez P, Bockamp E, Hengstler JG, Gottgens B, Sánchez MJ. Characterization of a Fetal Liver Cell Population Endowed with Long-Term Multiorgan Endothelial Reconstitution Potential. Stem Cells. 2017 Feb;35(2):507-521. doi: 10.1002/stem.2494. Epub 2016 Sep 28.
PMID: 27615355

 

Karsdal MA, Henriksen K, Genovese F, Leeming DJ, Nielsen MJ, Riis BJ, Christiansen C, Byrjalsen I, Schuppan D. Serum endotrophin identifies optimal responders to PPARγ agonists in type 2 diabetes. Diabetologia. 2017 Jan;60(1):50-59. Epub 2016 Sep 8. PubMed PMID: 27631136.

 


Kim YO, Popov Y, Schuppan D.
Optimized Mouse Models for Liver Fibrosis.Methods Mol Biol. 2017;1559:279-296. doi: 10.1007/978-1-4939-6786-5_19. PubMed PMID: 28063051.

2016

Muenzner JK, Biersack B, Albrecht A, Rehm T, Lacher U, Milius W, Casini A, Zhang JJ, Ott I, Brabec V, Stuchlikova O, Andronache IC, Kaps L, Schuppan D, Schobert R. Ferrocenyl-Coupled N-Heterocyclic Carbene Complexes of Gold(I): A Successful Approach to Multinuclear Anticancer Drugs. Chemistry. 2016 Dec 23;22(52):18953-18962. doi: 10.1002/chem.201604246. Epub 2016 Nov 17. PubMed PMID: 27761940.

 

Marowsky A, Haenel K, Bockamp E, Heck R, Rutishauser S, Mule N, Kindler D, Rudin M, Arand M. Genetic enhancement of microsomal epoxide hydrolase improves metabolic detoxification but impairs cerebral blood flow regulation. Arch Toxicol. 2016 Dec;90(12):3017-3027. Epub 2016 Feb 2.
PMID: 26838043

 


Nielsen MJ, Karsdal MA, Kazankov K, Grønbaek H, Krag A, Leeming DJ, Schuppan D, George J.
Fibrosis is not just fibrosis - basement membrane modelling and
collagen metabolism differs between hepatitis B- and C-induced injury. Aliment Pharmacol Ther. 2016 Dec;44(11-12):1242-1252. doi: 10.1111/apt.13819. Epub 2016
Oct 3. PubMed PMID: 27696451.

 

Karsdal MA, Henriksen K, Nielsen MJ, Byrjalsen I, Leeming DJ, Gardner S, Goodman Z, Patel K, Krag A, Christiansen C, Schuppan D. Fibrogenesis assessed by
serological type III collagen formation identifies patients with progressive liver fibrosis and responders to a potential antifibrotic therapy. Am J Physiol
Gastrointest Liver Physiol. 2016 Dec 1;311(6):G1009-G1017. doi: 10.1152/ajpgi.00283.2016. Epub 2016 Oct 20. PubMed PMID: 27765759.

 

Gehrke N, Wörns MA, Huber Y, Hess M, Straub BK, Hövelmeyer N, Waisman A, Kim YO, Schuppan D, Galle PR, Schattenberg JM. Hepatic B cell leukemia-3 promotes
hepatic steatosis and inflammation through insulin-sensitive metabolic transcription factors. J Hepatol. 2016 Dec;65(6):1188-1197. doi:
10.1016/j.jhep.2016.06.026. Epub 2016 Jul 9. PubMed PMID: 27405060.

 

Müller LK, Kaps L, Schuppan D, Brose A, Chai W, Fischer K, Müller S, Frey H, Schmidt M, Mohr K. Physicochemical and Preclinical Evaluation of Spermine-Derived
Surfactant Liposomes for in Vitro and in Vivo siRNA-Delivery to Liver Macrophages. Mol Pharm. 2016 Nov 7;13(11):3636-3647. Epub 2016 Oct 18. PubMed
PMID: 27700112.


Raker VK, Ook KY, Haub J, Lorenz N, Schmidt T, Stegemann A, Böhm M, Schuppan D, Steinbrink K.
Myeloid cell populations and fibrogenic parameters in bleomycin-
and HOCl-induced fibrosis. Exp Dermatol. 2016 Nov;25(11):887-894. doi:10.1111/exd.13124. PubMed PMID: 27307019.


Qureshi MA, Kim YO, Schuppan D.
Hepatocellular carcinoma in nonalcoholic fatty liver disease: A link between oxidative stress and T-cell suppression.
Hepatology. 2016 Nov;64(5):1794-1797. doi: 10.1002/hep.28815. PubMed PMID: 27629157.

 

Waisman A, Hövelmeyer N, Diefenbach A, Schuppan D, Reddehase MJ, Kleinert H, Kaina B, Grabbe S, Galle PR, Theobald M, Zipp F, Sahin U, Türeci Ö, Kreiter S, Langguth P, Decker H, van Zandbergen G, Schild H. Past, present and future of immunology in Mainz. Cell Immunol. 2016 Oct;308:1-6. doi:
10.1016/j.cellimm.2016.09.001. PubMed PMID: 27719802.

 

Caminero A, Galipeau HJ, McCarville JL, Johnston CW, Bernier SP, Russell AK, Jury J, Herran AR, Casqueiro J, Tye-Din JA, Surette MG, Magarvey NA, Schuppan D, Verdu EF. Duodenal Bacteria From Patients With Celiac Disease and Healthy Subjects Distinctly Affect Gluten Breakdown and Immunogenicity. Gastroenterology.2016 Oct;151(4):670-83. doi: 10.1053/j.gastro.2016.06.041. Epub 2016 Jun 30. PubMed PMID: 27373514.

 

Tuettenberg A, Steinbrink K, Schuppan D. Myeloid cells as orchestrators of the tumor microenvironment: novel targets for nanoparticular cancer therapy.
Nanomedicine (Lond). 2016 Oct;11(20):2735-2751. Epub 2016 Sep 23. Review. PubMed PMID: 27658725.


Grabbe S, Landfester K, Schuppan D, Barz M, Zentel R.
Nanoparticles and the immune system: challenges and opportunities. Nanomedicine (Lond). 2016
Oct;11(20):2621-2624. Epub 2016 Sep 20. PubMed PMID: 27649323.

 

Foerster F, Bamberger D, Schupp J, Weilbächer M, Kaps L, Strobl S, Radi L,Diken M, Strand D, Tuettenberg A, Wich PR, Schuppan D. Dextran-based therapeutic
nanoparticles for hepatic drug delivery. Nanomedicine (Lond). 2016 Oct;11(20):2663-2677. Epub 2016 Sep 15. PubMed PMID: 27628057.


Wei G, Tian N, Siezen R, Schuppan D, Helmerhorst EJ.
Identification of food-grade subtilisins as gluten-degrading enzymes to treat celiac disease. Am J
Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G571-80. doi: 10.1152/ajpgi.00185.2016. Epub 2016 Jul 28. PubMed PMID: 27469368; PubMed Central
PMCID: PMC5076000.

 

Teufel A, Itzel T, Erhart W, Brosch M, Wang XY, Kim YO, von Schönfels W, Herrmann A, Brückner S, Stickel F, Dufour JF, Chavakis T, Hellerbrand C, Spang R, Maass T, Becker T, Schreiber S, Schafmayer C, Schuppan D, Hampe J. Comparison of Gene Expression Patterns Between Mouse Models of Nonalcoholic Fatty Liver Disease and Liver Tissues From Patients. Gastroenterology. 2016 Sep;151(3):513-525.e0. doi: 10.1053/j.gastro.2016.05.051. Epub 2016 Jun 16. PubMed PMID: 27318147.

 

Hahn SA, Neuhoff A, Landsberg J, Schupp J, Eberts D, Leukel P, Bros M, Weilbaecher M, Schuppan D, Grabbe S, Tueting T, Lennerz V, Sommer C, Jonuleit H,
Tuettenberg A.
A key role of GARP in the immune suppressive tumor microenvironment. Oncotarget. 2016 Jul 12;7(28):42996-43009. doi:
10.18632/oncotarget.9598. PubMed PMID: 27248166; PubMed Central PMCID: PMC5190003.

 

Hocher B, Haumann H, Rahnenführer J, Reichetzeder C, Kalk P, Pfab T, Tsuprykov O, Winter S, Hofmann U, Li J, Püschel GP, Lang F, Schuppan D, Schwab M,
Schaeffeler E.
Maternal eNOS deficiency determines a fatty liver phenotype of the offspring in a sex dependent manner. Epigenetics. 2016 Jul 2;11(7):539-52. doi:
10.1080/15592294.2016.1184800. Epub 2016 May 13. PubMed PMID: 27175980; PubMed Central PMCID: PMC4939931.


Adriaanse MP, Leffler DA, Kelly CP, Schuppan D, Najarian RM, Goldsmith JD, Buurman WA, Vreugdenhil AC.
Serum I-FABP Detects Gluten Responsiveness in Adult
Celiac Disease Patients on a Short-Term Gluten Challenge. Am J Gastroenterol.2016 Jul;111(7):1014-22. doi: 10.1038/ajg.2016.162. Epub 2016 May 17. PubMed PMID: 27185075.


Schuppan D.
[Celiac disease : Pathogenesis, clinics, epidemiology,diagnostics, therapy]. Bundesgesundheitsblatt Gesundheitsforschung
Gesundheitsschutz. 2016 Jul;59(7):827-35. doi: 10.1007/s00103-016-2364-1. Review. German. PubMed PMID: 27273303.


Nuhn L, Kaps L, Diken M, Schuppan D, Zentel R.
Reductive Decationizable Block Copolymers for Stimuli-Responsive mRNA Delivery. Macromol Rapid Commun. 2016
Jun;37(11):924-33. doi: 10.1002/marc.201600046. Epub 2016 Apr 14. PubMed PMID: 27075781.


Willms A, Müller C, Julich H, Klein N, Schwab R, Güsgen C, Richardsen I, Schaaf S, Krawczyk M, Krawczyk M, Lammert F, Schuppan D, Lukacs-Kornek V, Kornek M.
Tumour-associated circulating microparticles: A novel liquid biopsy tool for screening and therapy monitoring of colorectal carcinoma and other epithelial
neoplasia. Oncotarget. 2016 May 24;7(21):30867-75. doi: 10.18632/oncotarget.9018.PubMed PMID: 27127176; PubMed Central PMCID: PMC5058724.


Landefeld C, Kentouche K, Gruhn B, Stauch T, Rößler S, Schuppan D, Whatley SD, Beck JF, Stölzel U.
X-linked protoporphyria: Iron supplementation improves
protoporphyrin overload, liver damage and anaemia. Br J Haematol. 2016 May;173(3):482-4. doi: 10.1111/bjh.13612. Epub 2015 Jul 20. PubMed PMID:26193873.


Liu SB, Ikenaga N, Peng ZW, Sverdlov DY, Greenstein A, Smith V, Schuppan D, Popov Y.
Lysyl oxidase activity contributes to collagen stabilization during
liver fibrosis progression and limits spontaneous fibrosis reversal in mice.FASEB J. 2016 Apr;30(4):1599-609. doi: 10.1096/fj.14-268425. Epub 2015 Dec 23. PubMed PMID: 26700732.

 

Bernuth S, Yagmur E, Schuppan D, Sprinzl MF, Zimmermann A, Schad A, Kittner JM, Weyer V, Knapstein J, Schattenberg JM, Wörns MA, Galle PR, Zimmermann T.Early changes in dynamic biomarkers of liver fibrosis in hepatitis C virus-infected patients treated with sofosbuvir. Dig Liver Dis. 2016
Mar;48(3):291-7. doi: 10.1016/j.dld.2015.09.015. Epub 2015 Oct 3. PubMed PMID: 26514736.

 

Locatelli L, Cadamuro M, Spirlì C, Fiorotto R, Lecchi S, Morell CM, Popov Y, Scirpo R, De Matteis M, Amenduni M, Pietrobattista A, Torre G, Schuppan D, Fabris
L, Strazzabosco M.
Macrophage recruitment by fibrocystin-defective biliary epithelial cells promotes portal fibrosis in congenital hepatic fibrosis.
Hepatology. 2016 Mar;63(3):965-82. doi: 10.1002/hep.28382. Epub 2016 Jan 16.PubMed PMID: 26645994; PubMed Central PMCID: PMC4764460.

 

Eckert C, Kim YO, Julich H, Heier EC, Klein N, Krause E, Tschernig T, Kornek M, Lammert F, Schuppan D, Lukacs-Kornek V. Podoplanin discriminates distinct
stromal cell populations and a novel progenitor subset in the liver. Am J Physiol Gastrointest Liver Physiol. 2016 Jan 1;310(1):G1-12. doi:
10.1152/ajpgi.00344.2015. Epub 2015 Nov 12. PubMed PMID: 26564718; PubMed Central PMCID: PMC4698439.

 

Behm B, Di Fazio P, Michl P, Neureiter D, Kemmerling R, Hahn EG, Strobel D, Gress T, Schuppan D, Wissniowski TT. Additive antitumour response to the rabbit
VX2 hepatoma by combined radio frequency ablation and toll like receptor 9 stimulation. Gut. 2016 Jan;65(1):134-43. doi: 10.1136/gutjnl-2014-308286. Epub 2014 Dec 18. PubMed PMID: 25524262.

 


Peng ZW, Ikenaga N, Liu SB, Sverdlov DY, Vaid KA, Dixit R, Weinreb PH, Violette S, Sheppard D, Schuppan D, Popov Y.
Integrin αvβ6 critically regulates
hepatic progenitor cell function and promotes ductular reaction, fibrosis, and tumorigenesis. Hepatology. 2016 Jan;63(1):217-32. doi: 10.1002/hep.28274. Epub
2015 Nov 23. PubMed PMID: 26448099; PubMed Central PMCID: PMC5312042.


Karsdal MA, Genovese F, Madsen EA, Manon-Jensen T, Schuppan D.
Collagen and tissue turnover as a function of age: Implications for fibrosis. J Hepatol. 2016
Jan;64(1):103-9. doi: 10.1016/j.jhep.2015.08.014. Epub 2015 Aug 22. PubMed PMID: 26307398.

2015

Kaps L, Nuhn L, Aslam M, Brose A, Foerster F, Rosigkeit S, Renz P, Heck R, Kim YO, Lieberwirth I, Schuppan D, Zentel R. In Vivo Gene-Silencing in Fibrotic Liver by siRNA-Loaded Cationic Nanohydrogel Particles. Adv Healthc Mater. 2015 Dec 30;4(18):2809-15. doi: 10.1002/adhm.201500826. Epub 2015 Dec 2. PubMed PMID: 26627192.

 

Tian N, Leffler DA, Kelly CP, Hansen J, Marietta EV, Murray JA, Schuppan D,Helmerhorst EJ. Despite sequence homologies to gluten, salivary proline-rich
proteins do not elicit immune responses central to the pathogenesis of celiac disease. Am J Physiol Gastrointest Liver Physiol. 2015 Dec 1;309(11):G910-7. doi:
10.1152/ajpgi.00157.2015. Epub 2015 Oct 1. PubMed PMID: 26505973; PubMed Central PMCID: PMC4669355.


Jiménez Calvente C, Sehgal A, Popov Y, Kim YO, Zevallos V, Sahin U, Diken M, Schuppan D.
Specific hepatic delivery of procollagen α1(I) small interfering RNA in lipid-like nanoparticles resolves liver fibrosis. Hepatology. 2015 Oct;62(4):1285-97. doi: 10.1002/hep.27936. Epub 2015 Aug 28. PubMed PMID: 26096209.


Tian N, Messana I, Leffler DA, Kelly CP, Hansen J, Cabras T, D'Alessandro A, Schuppan D, Castagnola M, Helmerhorst EJ.
Salivary proline-rich proteins and gluten: Do structural similarities suggest a role in celiac disease? Proteomics Clin Appl. 2015 Oct;9(9-10):953-64. doi: 10.1002/prca.201400170. Epub 2015 Apr
24. PubMed PMID: 25726832.


Schuppan D.
Liver fibrosis: Common mechanisms and antifibrotic therapies.Clin Res Hepatol Gastroenterol. 2015 Sep;39 Suppl 1:S51-9. doi: 10.1016/j.clinre.2015.05.005. Epub 2015 Jul 17. Review. PubMed PMID: 26189980.


Torok NJ, Dranoff JA, Schuppan D, Friedman SL. Strategies and endpoints of antifibrotic drug trials: Summary and recommendations from the AASLD Emerging Trends Conference, Chicago, June 2014. Hepatology. 2015 Aug;62(2):627-34. doi:10.1002/hep.27720. Epub 2015 Mar 10. Review. PubMed PMID: 25626988.

 

Catassi C, Elli L, Bonaz B, Bouma G, Carroccio A, Castillejo G, Cellier C, Cristofori F, de Magistris L, Dolinsek J, Dieterich W, Francavilla R, Hadjivassiliou M, Holtmeier W, Körner U, Leffler DA, Lundin KE, Mazzarella G, Mulder CJ, Pellegrini N, Rostami K, Sanders D, Skodje GI, Schuppan D, Ullrich R, Volta U, Williams M, Zevallos VF, Zopf Y, Fasano A. Diagnosis of Non-Celiac Gluten Sensitivity (NCGS): The Salerno Experts' Criteria. Nutrients. 2015 Jun 18;7(6):4966-77. doi: 10.3390/nu7064966. PubMed PMID: 26096570; PubMed Central PMCID: PMC4488826.


Wei G, Tian N, Valery AC, Zhong Y, Schuppan D, Helmerhorst EJ.
Identification of Pseudolysin (lasB) as an Aciduric Gluten-Degrading Enzyme with High Therapeutic Potential for Celiac Disease. Am J Gastroenterol. 2015 Jun;110(6):899-908. doi: 10.1038/ajg.2015.97. Epub 2015 Apr 21. PubMed PMID:
25895519; PubMed Central PMCID: PMC4461489.


Schuppan D, Pickert G, Ashfaq-Khan M, Zevallos V.
Non-celiac wheat sensitivity: differential diagnosis, triggers and implications. Best Pract Res Clin Gastroenterol. 2015 Jun;29(3):469-76. doi: 10.1016/j.bpg.2015.04.002. Epub 2015 May 8. Review. PubMed PMID: 26060111.

 

Karsdal MA, Manon-Jensen T, Genovese F, Kristensen JH, Nielsen MJ, Sand JM, Hansen NU, Bay-Jensen AC, Bager CL, Krag A, Blanchard A, Krarup H, Leeming DJ, Schuppan D. Novel insights into the function and dynamics of extracellular matrix in liver fibrosis. Am J Physiol Gastrointest Liver Physiol. 2015 May 15;308(10):G807-30. doi: 10.1152/ajpgi.00447.2014. Epub 2015 Mar 12. Review. PubMed PMID: 25767261; PubMed Central PMCID: PMC4437019.

 

Corley DA, Schuppan D. Food, the immune system, and the gastrointestinal tract. Gastroenterology. 2015 May;148(6):1083-6. doi: 10.1053/j.gastro.2015.03.043. Epub 2015 Mar 30. PubMed PMID: 25835098; PubMed Central PMCID: PMC4409565.


Fasano A, Sapone A, Zevallos V, Schuppan D.
Nonceliac gluten sensitivity. Gastroenterology. 2015 May;148(6):1195-204. doi: 10.1053/j.gastro.2014.12.049. Epub 2015 Jan 9. Review. PubMed PMID: 25583468.

 

Mehal WZ, Schuppan D. Antifibrotic therapies in the liver. Semin Liver Dis. 2015 May;35(2):184-98. doi: 10.1055/s-0035-1550055. Epub 2015 May 14. Review. PubMed PMID: 25974903; PubMed Central PMCID: PMC5743222.


Lindner U, Schuppan D, Schleithoff L, Habeck JO, Grodde T, Kirchhof K,Stoelzel U.
Aceruloplasminaemia: a family with a novel mutation and long-term therapy with deferasirox. Horm Metab Res. 2015 Apr;47(4):303-8. doi: 10.1055/s-0034-1383650. Epub 2014 Aug 4. PubMed PMID: 25089372.


Jia J, Hou J, Ding H, Chen G, Xie Q, Wang Y, Zeng M, Zhao J, Wang T, Hu X, Schuppan D.
Transient elastography compared to serum markers to predict liver fibrosis in a cohort of Chinese patients with chronic hepatitis B. J Gastroenterol Hepatol. 2015 Apr;30(4):756-62. doi: 10.1111/jgh.12840. PubMed PMID: 25353058.


Trautwein C, Friedman SL, Schuppan D, Pinzani M.
Hepatic fibrosis: Concept to treatment. J Hepatol. 2015 Apr;62(1 Suppl):S15-24. doi:10.1016/j.jhep.2015.02.039. Review. PubMed PMID: 25920084.


Felber J, Stallmach A, Schuppan D.
[Comment]. Z Gastroenterol. 2015 Apr;53(4):342-3. German. PubMed PMID: 26042232.


Stallmach A, Schuppan D.
[Diagnostics and treatment of celiac disease]. Dtsch Med Wochenschr. 2015 Feb;140(3):198. doi: 10.1055/s-0041-100132. Epub 2015 Feb 6. Review. German. PubMed PMID: 5658409.

 

Nielsen MJ, Veidal SS, Karsdal MA, Ørsnes-Leeming DJ, Vainer B, Gardner SD, Hamatake R, Goodman ZD, Schuppan D, Patel K. Plasma Pro-C3 (N-terminal type III collagen propeptide) predicts fibrosis progression in patients with chronic hepatitis C. Liver Int. 2015 Feb;35(2):429-37. doi: 10.1111/liv.12700. Epub 2014 
Oct 29. PubMed PMID: 25308921.


Schuppan D, Zevallos V.
Wheat amylase trypsin inhibitors as nutritional activators of innate immunity. Dig Dis. 2015;33(2):260-3. doi: 10.1159/000371476. Epub 2015 Apr 22. Review. PubMed PMID: 25925932.


Kahaly GJ, Schuppan D. Celiac disease and endocrine autoimmunity. Dig Dis. 2015;33(2):155-61. doi: 10.1159/000369535. Epub 2015 Apr 22. Review. PubMed PMID: 25925917.


Mulder CJ, Schuppan D.
Small bowel: from sideline to center stage in gastroenterology. Dig Dis. 2015;33(2):113-4. doi: 10.1159/000371650. Epub 2015 Apr 22. PubMed PMID: 25925910.

 

Kubisch I, de Albuquerque A, Schuppan D, Kaul S, Schaich M, Stölzel U. Prognostic Role of a Multimarker Analysis of Circulating Tumor Cells in Advanced Gastric and Gastroesophageal Adenocarcinomas. Oncology. 2015;89(5):294-303. doi: 10.1159/000437373. Epub 2015 Aug 28. PubMed PMID: 26315108.

2014

Yoshida S, Ikenaga N, Liu SB, Peng ZW, Chung J, Sverdlov DY, Miyamoto M, Kim YO, Ogawa S, Arch RH, Schuppan D, Popov Y. Extrahepatic platelet-derived growth factor-β, delivered by platelets, promotes activation of hepatic stellate cells and biliary fibrosis in mice. Gastroenterology. 2014 Dec;147(6):1378-92. doi: 10.1053/j.gastro.2014.08.038. Epub 2014 Aug 28. PubMed PMID: 25173753.

 

Fisher FM, Chui PC, Nasser IA, Popov Y, Cunniff JC, Lundasen T, Kharitonenkov A, Schuppan D, Flier JS, Maratos-Flier E. Fibroblast growth factor 21 limits lipotoxicity by promoting hepatic fatty acid activation in mice on methionine and choline-deficient diets. Gastroenterology. 2014 Nov;147(5):1073-83.e6. doi: 10.1053/j.gastro.2014.07.044. Epub 2014 Jul 30.PubMed PMID: 25083607; PubMed Central PMCID: PMC4570569.

Fritscher-Ravens A, Schuppan D, Ellrichmann M, Schoch S, Röcken C, Brasch J,Bethge J, Böttner M, Klose J, Milla PJ. Confocal endomicroscopy shows food-associated changes in the intestinal mucosa of patients with irritable bowel syndrome. Gastroenterology. 2014 Nov;147(5):1012-20.e4. doi:10.1053/j.gastro.2014.07.046. Epub 2014 Jul 30. PubMed PMID: 25083606.


Tian N, Wei G, Schuppan D, Helmerhorst EJ.
Effect of Rothia mucilaginosa enzymes on gliadin (gluten) structure, deamidation, and immunogenic epitopes relevant to celiac disease. Am J Physiol Gastrointest Liver Physiol. 2014 Oct 15;307(8):G769-76. doi: 10.1152/ajpgi.00144.2014. Epub 2014 Aug 21. PubMed PMID:  25147233; PubMed Central PMCID: PMC4200315.

 

Ponto KA, Schuppan D, Zwiener I, Binder H, Mirshahi A, Diana T, Pitz S, Pfeiffer N, Kahaly GJ. Thyroid-associated orbitopathy is linked to gastrointestinal autoimmunity. Clin Exp Immunol. 2014 Oct;178(1):57-64. doi: 10.1111/cei.12395. PubMed PMID: 24903731; PubMed Central PMCID: PMC4360194.

 

Zhang L, Schuppan D. Traditional Chinese Medicine (TCM) for fibrotic liver disease: hope and hype. J Hepatol. 2014 Jul;61(1):166-8. doi:
10.1016/j.jhep.2014.03.009. Epub 2014 Apr 26. Review. PubMed PMID: 24780816.

 

Felber J, Aust D, Baas S, Bischoff S, Bläker H, Daum S, Keller R, Koletzko S, Laass M, Nothacker M, Roeb E, Schuppan D, Stallmach A. [Results of a S2k-Consensus Conference of the German Society of Gastroenterolgy, Digestive- and Metabolic Diseases (DGVS) in conjunction with the German Coeliac Society (DZG) regarding coeliac disease, wheat allergy and wheat sensitivity]. Z Gastroenterol.2014 Jul;52(7):711-43. doi: 10.1055/s-0034-1366687. Epub 2014 Jul 15. German. PubMed PMID: 25026010.


Muenzner JK, Biersack B, Kalie H, Andronache IC, Kaps L, Schuppan D, Sasse F, Schobert R.
Gold(I) biscarbene complexes derived from vascular-disrupting combretastatin A-4 address different targets and show antimetastatic potential. ChemMedChem. 2014 Jun;9(6):1195-204. doi: 10.1002/cmdc.201400049. Epub 2014 Mar 19. PubMed PMID: 24648184.


Stein J, Schuppan D.
Coeliac Disease - New Pathophysiological Findings and Their Implications for Therapy. Viszeralmedizin. 2014 Jun;30(3):156-65. doi:
10.1159/000365099. Review. PubMed PMID: 26288589; PubMed Central PMCID: PMC4513807.

 

Yang L, Kwon J, Popov Y, Gajdos GB, Ordog T, Brekken RA, Mukhopadhyay D, Schuppan D, Bi Y, Simonetto D, Shah VH. Vascular endothelial growth factor promotes fibrosis resolution and repair in mice. Gastroenterology. 2014 May;146(5):1339-50.e1. doi: 10.1053/j.gastro.2014.01.061. Epub 2014 Feb 4. PubMed PMID: 24503129; PubMed Central PMCID: PMC4001704.

 

Freitag TL, Loponen J, Messing M, Zevallos V, Andersson LC, Sontag-Strohm T,Saavalainen P, Schuppan D, Salovaara H, Meri S. Testing safety of germinated rye  sourdough in a celiac disease model based on the adoptive transfer of prolamin-primed memory T cells into lymphopenic mice. Am J Physiol Gastrointest
Liver Physiol. 2014 Mar;306(6):G526-34. doi: 10.1152/ajpgi.00136.2013. Epub 2014 Jan 23. PubMed PMID: 24458020.

2013

Schuppan D, Zimmer KP. The diagnosis and treatment of celiac disease. Dtsch Arztebl Int. 2013 Dec 6;110(49):835-46. doi: 10.3238/arztebl.2013.0835. Review.PubMed PMID: 24355936; PubMed Central PMCID: PMC3884535.

 

Cabezas-Wallscheid N, Eichwald V, de Graaf J, Löwer M, Lehr HA, Kreft A, Eshkind L, Hildebrandt A, Abassi Y, Heck R, Dehof AK, Ohngemach S, Sprengel R, Wörtge S, Schmitt S, Lotz J, Meyer C, Kindler T, Zhang DE, Kaina B, Castle JC, Trumpp A, Sahin U, Bockamp E. Instruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model. EMBO Mol Med. 2013 Dec;5(12):1804-20. doi: 10.1002/emmm.201302661. Epub 2013 Oct 4.
PMID: 24124051


Yoshida S, Kornek M, Ikenaga N, Schmelzle M, Masuzaki R, Csizmadia E, Wu Y, Robson SC, Schuppan D.
Sublethal heat treatment promotes epithelial-mesenchymal transition and enhances the malignant potential of hepatocellular carcinoma.Hepatology. 2013 Nov;58(5):1667-80. doi: 10.1002/hep.26526. Epub 2013 Sep 19. PubMed PMID: 23729316.


Lukacs-Kornek V, Schuppan D.
Dendritic cells in liver injury and fibrosis:shortcomings and promises. J Hepatol. 2013 Nov;59(5):1124-6. doi: 10.1016/j.jhep.2013.05.033. Epub 2013 May 29. PubMed PMID: 23727306.

 

Catassi C, Bai JC, Bonaz B, Bouma G, Calabrò A, Carroccio A, Castillejo G, Ciacci C, Cristofori F, Dolinsek J, Francavilla R, Elli L, Green P, Holtmeier W, Koehler P, Koletzko S, Meinhold C, Sanders D, Schumann M, Schuppan D, Ullrich R, Vécsei A, Volta U, Zevallos V, Sapone A, Fasano A. Non-Celiac Gluten sensitivity:
the new frontier of gluten related disorders. Nutrients. 2013 Sep 26;5(10):3839-53. doi: 10.3390/nu5103839. Review. PubMed PMID: 24077239.


Fernandez-Feo M, Wei G, Blumenkranz G, Dewhirst FE, Schuppan D, Oppenheim FG, Helmerhorst EJ.
The cultivable human oral gluten-degrading microbiome and its potential implications in coeliac disease and gluten sensitivity. Clin Microbiol Infect. 2013 Sep;19(9):E386-94. doi: 10.1111/1469-0691.12249. Epub 2013 May 28. PubMed PMID: 23714165; PubMed Central PMCID: PMC3749263.

 

Schuppan D, Schattenberg JM. Non-alcoholic steatohepatitis: pathogenesis and novel therapeutic approaches. J Gastroenterol Hepatol. 2013 Aug;28 Suppl 1:68-76. doi: 10.1111/jgh.12212. Review. PubMed PMID: 23855299.

 

Yanagisawa K, Yue S, van der Vliet HJ, Wang R, Alatrakchi N, Golden-Mason L, Schuppan D, Koziel MJ, Rosen HR, Exley MA. Ex vivo analysis of resident hepatic pro-inflammatory CD1d-reactive T cells and hepatocyte surface CD1d expression in hepatitis C. J Viral Hepat. 2013 Aug;20(8):556-65. doi: 10.1111/jvh.12081. Epub 2013 Mar 11. PubMed PMID: 23808994; PubMed Central PMCID: PMC4054599.


Kuramitsu K, Sverdlov DY, Liu SB, Csizmadia E, Burkly L, Schuppan D, Hanto DW, Otterbein LE, Popov Y.
Failure of fibrotic liver regeneration in mice is linked to a severe fibrogenic response driven by hepatic progenitor cell activation. Am J Pathol. 2013 Jul;183(1):182-94. doi: 10.1016/j.ajpath.2013.03.018. Epub 2013 May 14. PubMed PMID: 23680654; PubMed Central PMCID: PMC3702745.

 

Leffler D, Schuppan D, Pallav K, Najarian R, Goldsmith JD, Hansen J, Kabbani T, Dennis M, Kelly CP. Kinetics of the histological, serological and symptomatic responses to gluten challenge in adults with coeliac disease. Gut. 2013 Jul;62(7):996-1004. doi: 10.1136/gutjnl-2012-302196. Epub 2012 May 22. PubMed
PMID: 22619366; PubMed Central PMCID: PMC3525791.

 

Olinga P, Schuppan D. Precision-cut liver slices: a tool to model the liver ex vivo. J Hepatol. 2013 Jun;58(6):1252-3. doi: 10.1016/j.jhep.2013.01.009. Epub 2013 Jan 18. PubMed PMID: 23336979.

 

Chowdhury S, Chen Y, Yao TW, Ajami K, Wang XM, Popov Y, Schuppan D, Bertolino P, McCaughan GW, Yu DM, Gorrell MD. Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver. World J Gastroenterol. 2013 May 21;19(19):2883-93. doi: 10.3748/wjg.v19.i19.2883. PubMed
PMID: 23704821; PubMed Central PMCID: PMC3660813.


Schuppan D, Kim YO.
Evolving therapies for liver fibrosis. J Clin Invest. 2013 May;123(5):1887-901. doi: 10.1172/JCI66028. Epub 2013 May 1. Review. PubMed PMID: 23635787; PubMed Central PMCID: PMC3635731.

 

Berenguer M, Schuppan D. Progression of liver fibrosis in post-transplant hepatitis C: mechanisms, assessment and treatment. J Hepatol. 2013 May;58(5):1028-41. doi: 10.1016/j.jhep.2012.12.014. Epub 2012 Dec 20. Review.PubMed PMID: 23262248.


Zevallos VF, Schuppan D.
Refractory coeliac disease: one step closer to the origin of aberrant lymphocytes. Gut. 2013 Apr;62(4):485-6. doi:10.1136/gutjnl-2012-303030. Epub 2012 Sep 1. PubMed PMID: 22942236.


Weng SY, Schuppan D. AMPK regulates macrophage polarization in adipose tissue inflammation and NASH. J Hepatol. 2013 Mar;58(3):619-21. doi: 10.1016/j.jhep.2012.09.031. Epub 2012 Oct 6. PubMed PMID: 23046670.


Bai JC, Fried M, Corazza GR, Schuppan D, Farthing M, Catassi C, Greco L, Cohen H, Ciacci C, Eliakim R, Fasano A, González A, Krabshuis JH, LeMair A;
World Gastroenterology Organization. World Gastroenterology Organisation global guidelines on celiac disease. J Clin Gastroenterol. 2013 Feb;47(2):121-6. doi: 10.1097/MCG.0b013e31827a6f83. PubMed PMID: 23314668.

 

Schmelzle M, Splith K, Andersen LW, Kornek M, Schuppan D, Jones-Bamman C, Nowak M, Toxavidis V, Salhanick SD, Han L, Schulte am Esch J, Jonas S, Donnino MW, Robson SC. Increased plasma levels of microparticles expressing CD39 and CD133 in acute liver injury. Transplantation. 2013 Jan 15;95(1):63-9. doi:10.1097/TP.0b013e318278d3cd. PubMed PMID: 23232366; PubMed Central PMCID: PMC3536489.

 

Kwong GA, von Maltzahn G, Murugappan G, Abudayyeh O, Mo S, Papayannopoulos IA, Sverdlov DY, Liu SB, Warren AD, Popov Y, Schuppan D, Bhatia SN. Mass-encoded synthetic biomarkers for multiplexed urinary monitoring of disease. Nat Biotechnol. 2013 Jan;31(1):63-70. doi: 10.1038/nbt.2464. Epub 2012 Dec 16. PubMed PMID: 23242163; PubMed Central PMCID: PMC3542405.

 

Tam WF, Hähnel PS, Schüler A, Lee BH, Okabe R, Zhu N, Pante SV, Raffel G, Mercher T, Wernig G, Bockamp E, Sasca D, Kreft A, Robinson GW, Hennighausen L, Gilliland DG, Kindler T. STAT5 is crucial to maintain leukemic stem cells in acute myelogenous leukemias induced by MOZ-TIF2. Cancer Res. 2013 Jan 1;73(1):373-84. doi: 10.1158/0008-5472.CAN-12-0255. Epub 2012 Nov 13.
PMID: 23149921

 

 

2012

Junker Y, Zeissig S, Kim SJ, Barisani D, Wieser H, Leffler DA, Zevallos V,Libermann TA, Dillon S, Freitag TL, Kelly CP, Schuppan D. Wheat amylase trypsin inhibitors drive intestinal inflammation via activation of toll-like receptor 4. J Exp Med. 2012 Dec 17;209(13):2395-408. doi: 10.1084/jem.20102660. Epub 2012 Dec
3. PubMed PMID: 23209313; PubMed Central PMCID: PMC3526354.

 

Li S, Vriend LE, Nasser IA, Popov Y, Afdhal NH, Koziel MJ, Schuppan D, Exley MA, Alatrakchi N. Hepatitis C virus-specific T-cell-derived transforming growth factor beta is associated with slow hepatic fibrogenesis. Hepatology. 2012 Dec;56(6):2094-105. doi: 10.1002/hep.25951. PubMed PMID: 22806830; PubMed Central PMCID: PMC3508175.

 

Kornek M, Schuppan D. Microparticles: Modulators and biomarkers of liver disease. J Hepatol. 2012 Nov;57(5):1144-6. doi: 10.1016/j.jhep.2012.07.029. Epub
2012 Aug 6. PubMed PMID: 22878465.


Mukherjee R, Kelly CP, Schuppan D.
Nondietary therapies for celiac disease. Gastrointest Endosc Clin N Am. 2012 Oct;22(4):811-31. doi:10.1016/j.giec.2012.09.001. Review. PubMed PMID: 23083995.


Klempner SJ, Choueiri TK, Yee E, Doyle LA, Schuppan D, Atkins MB.
Severe pazopanib-induced hepatotoxicity: clinical and histologic course in two patients.
J Clin Oncol. 2012 Sep 20;30(27):e264-8. doi: 10.1200/JCO.2011.41.0332. Epub 2012 Jul 16. PubMed PMID: 22802316.

 

Montier Y, Lorentz A, Krämer S, Sellge G, Schock M, Bauer M, Schuppan D, Bischoff SC. Central role of IL-6 and MMP-1 for cross talk between human
intestinal mast cells and human intestinal fibroblasts. Immunobiology. 2012 Sep;217(9):912-9. doi: 10.1016/j.imbio.2012.01.003. Epub 2012 Jan 4. PubMed PMID:22356938.

 

Schattenberg JM, Nagel M, Kim YO, Kohl T, Wörns MA, Zimmermann T, Schad A,Longerich T, Schuppan D, He YW, Galle PR, Schuchmann M. Increased hepatic fibrosis and JNK2-dependent liver injury in mice exhibiting hepatocyte-specific deletion of cFLIP. Am J Physiol Gastrointest Liver Physiol. 2012 Aug
15;303(4):G498-506. doi: 10.1152/ajpgi.00525.2011. Epub 2012 Jun 14. PubMed PMID: 22700824.

 

Reis M, Czupalla CJ, Ziegler N, Devraj K, Zinke J, Seidel S, Heck R, Thom S, Macas J, Bockamp E, Fruttiger M, Taketo MM, Dimmeler S, Plate KH, Liebner S. Endothelial Wnt/β-catenin signaling inhibits glioma angiogenesis and normalizes tumor blood vessels by inducing PDGF-B expression.
J Exp Med. 2012 Aug 27;209(9):1611-27. doi: 10.1084/jem.20111580. Epub 2012 Aug 20.
PMID: 22908324


Martin CR, Zaman MM, Ketwaroo GA, Bhutta AQ, Coronel E, Popov Y, Schuppan D, Freedman SD.
CFTR dysfunction predisposes to fibrotic liver disease in a murine
model. Am J Physiol Gastrointest Liver Physiol. 2012 Aug 15;303(4):G474-81. doi: 10.1152/ajpgi.00055.2012. Epub 2012 Jun 7. PubMed PMID: 22679000; PubMed Central
PMCID: PMC3423138.

 

Kornek M, Lynch M, Mehta SH, Lai M, Exley M, Afdhal NH, Schuppan D. Circulating microparticles as disease-specific biomarkers of severity of
inflammation in patients with hepatitis C or nonalcoholic steatohepatitis.Gastroenterology. 2012 Aug;143(2):448-58. doi: 10.1053/j.gastro.2012.04.031. Epub
2012 Apr 24. PubMed PMID: 22537612; PubMed Central PMCID: PMC3404266.

 

Pallav K, Leffler DA, Bennett M, Tariq S, Xu H, Kabbani T, Moss AC, Dennis M, Kelly CP, Schuppan D. Open conformation tissue transglutaminase testing for celiac dietary assessment. Dig Liver Dis. 2012 May;44(5):375-8. doi:10.1016/j.dld.2011.12.008. Epub 2012 Jan 18. PubMed PMID: 22261352; PubMed Central PMCID: PMC3384702.


Jürgensen C, Neser F, Boese-Landgraf J, Schuppan D, Stölzel U, Fritscher-Ravens A.
Endoscopic ultrasound-guided endoscopic necrosectomy of the
pancreas: is irrigation necessary? Surg Endosc. 2012 May;26(5):1359-63. doi: 10.1007/s00464-011-2039-9. Epub 2011 Nov 15. PubMed PMID: 22083336.


Kim YO, Schuppan D.
When GLP-1 hits the liver: a novel approach for insulin resistance and NASH. Am J Physiol Gastrointest Liver Physiol. 2012 Apr
15;302(8):G759-61. doi: 10.1152/ajpgi.00078.2012. Epub 2012 Mar 1. PubMed PMID: 22383493.

 

Schuppan D, Pinzani M. Anti-fibrotic therapy: lost in translation? J Hepatol. 2012;56 Suppl 1:S66-74. doi: 10.1016/S0168-8278(12)60008-7. Review.
PubMed PMID: 22300467.

 

Shimada M, Yoshida S, Masuzaki R, Schuppan D. Pitavastatin enhances antiviral efficacy of standard pegylated interferon plus ribavirin in patients
with chronic hepatitis C: a prospective randomized pilot study. J Hepatol. 2012 Jan;56(1):299-300. doi: 10.1016/j.jhep.2011.04.024. Epub 2011 Jun 28. PubMed PMID: 21718671.

2011

Schattenberg JM, Schuppan D. Nonalcoholic steatohepatitis: the therapeutic challenge of a global epidemic. Curr Opin Lipidol. 2011 Dec;22(6):479-88. doi:
10.1097/MOL.0b013e32834c7cfc. Review. PubMed PMID: 22002020.


Poelstra K, Schuppan D. Targeted therapy of liver fibrosis/cirrhosis and its complications. J Hepatol. 2011 Sep;55(3):726-728. doi:
10.1016/j.jhep.2011.04.008. Epub 2011 May 8. PubMed PMID: 21601600.


Bansal R, Prakash J, Post E, Beljaars L, Schuppan D, Poelstra K. Novel engineered targeted interferon-gamma blocks hepatic fibrogenesis in mice.
Hepatology. 2011 Aug;54(2):586-96. doi: 10.1002/hep.24395. Epub 2011 Jun 26.PubMed PMID: 21538439.

Seven G, Karatayli SC, Köse SK, Yakut M, Kabaçam G, Törüner M, Heper AO, Voelker M, Erden E, Bozdayi AM, Uzunalimoglu O, Bozkaya H, Yurdaydin C, Schuppan
D. Serum connective tissue markers as predictors of advanced fibrosis in patients with chronic hepatitis B and D. Turk J Gastroenterol. 2011 Jun;22(3):305-14.
PubMed PMID: 21805422.

 

Krusche CA, Holthöfer B, Hofe V, van de Sandt AM, Eshkind L, Bockamp E, Merx MW, Kant S, Windoffer R, Leube RE. Desmoglein 2 mutant mice develop cardiac fibrosis and dilation.  Basic Res Cardiol. 2011 Jun;106(4):617-33. doi: 10.1007/s00395-011-0175-y. Epub 2011 Apr 1.
PMID: 21455723


Roshan B, Leffler DA, Jamma S, Dennis M, Sheth S, Falchuk K, Najarian R, Goldsmith J, Tariq S, Schuppan D, Kelly CP. The incidence and clinical spectrum
of refractory celiac disease in a north american referral center. Am J Gastroenterol. 2011 May;106(5):923-8. doi: 10.1038/ajg.2011.104. Epub 2011 Apr 5.
PubMed PMID: 21468013.


Popov Y, Sverdlov DY, Sharma AK, Bhaskar KR, Li S, Freitag TL, Lee J, Dieterich W, Melino G, Schuppan D. Tissue transglutaminase does not affect
fibrotic matrix stability or regression of liver fibrosis in mice. Gastroenterology. 2011 May;140(5):1642-52. doi: 10.1053/j.gastro.2011.01.040.
Epub 2011 Jan 26. PubMed PMID: 21277850; PubMed Central PMCID: PMC3374132.


Lin W, Wu G, Li S, Weinberg EM, Kumthip K, Peng LF, Méndez-Navarro J, Chen WC, Jilg N, Zhao H, Goto K, Zhang L, Brockman MA, Schuppan D, Chung RT. HIV and
HCV cooperatively promote hepatic fibrogenesis via induction of reactive oxygen species and NFkappaB. J Biol Chem. 2011 Jan 28;286(4):2665-74. doi:
10.1074/jbc.M110.168286. Epub 2010 Nov 22. PubMed PMID: 21098019; PubMed Central PMCID: PMC3024762.


Ruehl M, Muche M, Freise C, Erben U, Neumann U, Schuppan D, Popov Y, Dieterich W, Zeitz M, Farndale RW, Somasundaram R. Hydroxyproline-containing
collagen analogs trigger the release and activation of collagen-sequestered proMMP-2 by competition with prodomain-derived peptide P33-42. Fibrogenesis
Tissue Repair. 2011 Jan 6;4(1):1. doi: 10.1186/1755-1536-4-1. PubMed PMID:21211003


Yedibela S, Demir R, Melling N, Aydin Ü, Schuppan D, Müller V, Hohenberger W, Schönleben F. Antiviral re-treatment of IFN-ribavirin non-responders for
recurrent post-transplantation hepatitis C. Clin Transplant. 2011 Jan-Feb;25(1):131-5. doi: 10.1111/j.1399-0012.2009.01201.x. PubMed PMID:20438578.


Kornek M, Popov Y, Libermann TA, Afdhal NH, Schuppan D. Human T cell microparticles circulate in blood of hepatitis patients and induce fibrolytic
activation of hepatic stellate cells. Hepatology. 2011 Jan;53(1):230-42. doi: 10.1002/hep.23999. Epub 2010 Oct 26. PubMed PMID: 20979056; PubMed Central PMCID:PMC3505073.


Jamma S, Leffler DA, Dennis M, Najarian RM, Schuppan DB, Sheth S, Kelly CP. Small intestinal release mesalamine for the treatment of refractory celiac
disease type I. J Clin Gastroenterol. 2011 Jan;45(1):30-3. doi: 10.1097/MCG.0b013e3181f42401. PubMed PMID: 20871406.

Zamakhchari M, Wei G, Dewhirst F, Lee J, Schuppan D, Oppenheim FG, Helmerhorst EJ. Identification of Rothia bacteria as gluten-degrading natural
colonizers of the upper gastro-intestinal tract. PLoS One. 2011;6(9):e24455. doi: 10.1371/journal.pone.0024455. Epub 2011 Sep 21. PubMed PMID: 21957450; PubMed Central PMCID: PMC3177827.

2010

Leffler DA, Schuppan D. Update on serologic testing in celiac disease. Am J Gastroenterol. 2010 Dec;105(12):2520-4. doi: 10.1038/ajg.2010.276. Review. PubMed
PMID: 21131921.


Urban TJ, Thompson AJ, Bradrick SS, Fellay J, Schuppan D, Cronin KD, Hong L, McKenzie A, Patel K, Shianna KV, McHutchison JG, Goldstein DB, Afdhal N. IL28B
genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C. Hepatology.
2010 Dec;52(6):1888-96. doi: 10.1002/hep.23912. Epub 2010 Oct 7. PubMed PMID: 20931559; PubMed Central PMCID: PMC3653303.


Shimada M, Yoshida S, Kornek M, Kim SJ, Schuppan D. A change of peginterferon may permit continuation of antiviral therapy in hepatitis C
virus-infected patients with interstitial pneumonitis. Liver Int. 2010 Nov;30(10):1552-4. doi: 10.1111/j.1478-3231.2010.02297.x. PubMed PMID: 20557455.


Helmerhorst EJ, Zamakhchari M, Schuppan D, Oppenheim FG. Discovery of a novel and rich source of gluten-degrading microbial enzymes in the oral cavity.
PLoS One. 2010 Oct 11;5(10):e13264. doi: 10.1371/journal.pone.0013264. PubMed PMID: 20948997; PubMed Central PMCID: PMC2952584.


Malik R, Schuppan D. Serum fibrosis markers to predict clinical and histological progression in hepatitis C non-responders. Gut. 2010
Oct;59(10):1312-3. doi: 10.1136/gut.2010.219162. PubMed PMID: 20833662.


Yoshida S, Shimada M, Kornek M, Kim SJ, Shimada K, Schuppan D. Elevated transaminases as a predictor of coma in a patient with anorexia nervosa: a case
report and review of the literature. J Med Case Rep. 2010 Sep 17;4:307. doi: 10.1186/1752-1947-4-307. PubMed PMID: 20849624; PubMed Central PMCID: PMC2945359.

 

Wörtge S, Eshkind L, Cabezas-Wallscheid N, Lakaye B, Kim J, Heck R, Abassi Y, Diken M, Sprengel R, Bockamp E. Tetracycline-controlled transgene activation using the ROSA26-iM2-GFP knock-in mouse strain permits GFP monitoring of DOX-regulated transgene-expression. BMC Dev Biol. 2010 Sep 3;10:95. doi: 10.1186/1471-213X-10-95. PMID: 20815887


Popov Y, Schuppan D. Epithelial-to-mesenchymal transition in liver fibrosis: dead or alive? Gastroenterology. 2010 Sep;139(3):722-5. doi:
10.1053/j.gastro.2010.07.015. Epub 2010 Aug 1. PubMed PMID: 20682361.


Malik R, Lai M, Sadiq A, Farnan R, Mehta S, Nasser I, Challies T, Schuppan D, Afdhal N. Comparison of transient elastography, serum markers and clinical
signs for the diagnosis of compensated cirrhosis. J Gastroenterol Hepatol. 2010 Sep;25(9):1562-8. doi: 10.1111/j.1440-1746.2010.06371.x. PubMed PMID: 20796156.

 

Hoehme S, Brulport M, Bauer A, Bedawy E, Schormann W, Hermes M, Puppe V, Gebhardt R, Zellmer S, Schwarz M, Bockamp E, Timmel T, Hengstler JG, Drasdo D.  Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration. Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10371-6. doi: 10.1073/pnas.0909374107. Epub 2010 May 19.
PMID: 20484673


Jamma S, Rubio-Tapia A, Kelly CP, Murray J, Najarian R, Sheth S, Schuppan D, Dennis M, Leffler DA. Celiac crisis is a rare but serious complication of celiac
disease in adults. Clin Gastroenterol Hepatol. 2010 Jul;8(7):587-90. doi: 10.1016/j.cgh.2010.04.009. Epub 2010 Apr 24. PubMed PMID: 20417725; PubMed
Central PMCID: PMC2900539.


Freitag TL, Cham C, Sung HH, Beilhack GF, Durinovic-Belló I, Patel SD, Bronson RT, Schuppan D, Sønderstrup G. Human risk allele HLA-DRB1*0405
predisposes class II transgenic Ab0 NOD mice to autoimmune pancreatitis. Gastroenterology. 2010 Jul;139(1):281-91. doi: 10.1053/j.gastro.2010.03.038. Epub
2010 Mar 18. PubMed PMID: 20303356; PubMed Central PMCID: PMC2902648.


Schuppan D, Gorrell MD, Klein T, Mark M, Afdhal NH. The challenge of developing novel pharmacological therapies for non-alcoholic steatohepatitis.
Liver Int. 2010 Jul;30(6):795-808. doi: 10.1111/j.1478-3231.2010.02264.x. Review. PubMed PMID: 20624207.


de Meijer VE, Sverdlov DY, Popov Y, Le HD, Meisel JA, Nosé V, Schuppan D, Puder M. Broad-spectrum matrix metalloproteinase inhibition curbs inflammation
and liver injury but aggravates experimental liver fibrosis in mice. PLoS One. 2010 Jun 25;5(6):e11256. doi: 10.1371/journal.pone.0011256. PubMed PMID:
20593020; PubMed Central PMCID: PMC2892485.


Robson SC, Schuppan D. Adenosine: tipping the balance towards hepatic steatosis and fibrosis. J Hepatol. 2010 Jun;52(6):941-3. doi:
10.1016/j.jhep.2010.02.009. Epub 2010 Mar 24. PubMed PMID: 20395005; PubMed Central PMCID: PMC2875264.


Dietrich C, Weiss C, Bockamp E, Brisken C, Roskams T, Morris R, Oesch-Bartlomowicz B, Oesch F.Stem cells in chemical carcinogenesis. Arch Toxicol. 2010 Mar;84(3):245-51. doi: 10.1007/s00204-009-0491-2. Epub 2009 Nov 26. No abstract available. PMID: 19941131


Popov Y, Sverdlov DY, Bhaskar KR, Sharma AK, Millonig G, Patsenker E, Krahenbuhl S, Krahenbuhl L, Schuppan D. Macrophage-mediated phagocytosis of
apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis. Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G323-34. doi:
10.1152/ajpgi.00394.2009. Epub 2010 Jan 7. PubMed PMID: 20056896; PubMed Central PMCID: PMC2838516.


Ciccocioppo R, Finamore A, Mengheri E, Millimaggi D, Esslinger B, Dieterich W, Papola F, Colangeli S, Tombolino V, Schuppan D, Corazza GR. Isolation and
characterization of circulating tissue transglutaminase-specific T cells in coeliac disease. Int J Immunopathol Pharmacol. 2010 Jan-Mar;23(1):179-91. PubMed
PMID: 20377989.


Popov Y, Schuppan D. CD8+ T cells drive adipose tissue inflammation--a novel clue for NASH pathogenesis? J Hepatol. 2010 Jan;52(1):130-2. doi:
10.1016/j.jhep.2009.10.019. Epub 2009 Oct 29. PubMed PMID: 19914729.

2009-2005

Lohwasser C, Neureiter D, Popov Y, Bauer M, Schuppan D. Role of the receptor for advanced glycation end products in hepatic fibrosis. World J Gastroenterol.
2009 Dec 14;15(46):5789-98. PubMed PMID: 19998499; PubMed Central PMCID: PMC2791271.


Bockamp E, Antunes C, Liebner S, Schmitt S, Cabezas-Wallscheid N, Heck R, Ohnngemach S, Oesch-Bartlomowicz B, Rickert C, Sanchez MJ, Hengstler J, Kaina B, Wilson A, Trumpp A, Eshkind L. In vivo fate mapping with SCL regulatory elements identifies progenitors for primitive and definitive hematopoiesis in mice. Mech Dev. 2009 Oct;126(10):863-72. doi: 10.1016/j.mod.2009.07.005. Epub 2009 Jul 23.
PMID: 19631738


Leffler DA, Dennis M, Edwards George J, Jamma S, Cook EF, Schuppan D, Kelly CP. A validated disease-specific symptom index for adults with celiac disease.
Clin Gastroenterol Hepatol. 2009 Dec;7(12):1328-34, 1334.e1-3. doi: 10.1016/j.cgh.2009.07.031. Epub 2009 Aug 7. PubMed PMID: 19665584.


Schuppan D, Junker Y, Barisani D. Celiac disease: from pathogenesis to novel therapies. Gastroenterology. 2009 Dec;137(6):1912-33. doi:
10.1053/j.gastro.2009.09.008. Epub 2009 Sep 18. Review. PubMed PMID: 19766641.


Freitag TL, Rietdijk S, Junker Y, Popov Y, Bhan AK, Kelly CP, Terhorst C, Schuppan D. Gliadin-primed CD4+CD45RBlowCD25- T cells drive gluten-dependent
small intestinal damage after adoptive transfer into lymphopenic mice. Gut. 2009 Dec;58(12):1597-605. doi: 10.1136/gut.2009.186361. Epub 2009 Aug 10. PubMed PMID:
19671544; PubMed Central PMCID: PMC3733237.


Marietta EV, Schuppan D, Murray JA. In vitro and in vivo models of celiac disease. Expert Opin Drug Discov. 2009 Nov;4(11):1113-23. doi:
10.1517/17460440903307417. Epub 2009 Oct 6. PubMed PMID: 23480432.


Patsenker E, Popov Y, Stickel F, Schneider V, Ledermann M, Sägesser H, Niedobitek G, Goodman SL, Schuppan D. Pharmacological inhibition of integrin
alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis. Hepatology. 2009 Nov;50(5):1501-11. doi: 10.1002/hep.23144. PubMed
PMID: 19725105; PubMed Central PMCID: PMC2779730.


Schuppan D, Popov Y. Rationale and targets for antifibrotic therapies. Gastroenterol Clin Biol. 2009 Oct-Nov;33(10-11):949-57. doi:
10.1016/j.gcb.2009.07.021. Epub 2009 Sep 1. Review. PubMed PMID: 19726145.


Popov Y, Schuppan D. Targeting liver fibrosis: strategies for development and validation of antifibrotic therapies. Hepatology. 2009 Oct;50(4):1294-306.
doi: 10.1002/hep.23123. Review. PubMed PMID: 19711424.


Elli L, Bergamini CM, Bardella MT, Schuppan D. Transglutaminases in inflammation and fibrosis of the gastrointestinal tract and the liver. Dig Liver
Dis. 2009 Aug;41(8):541-50. doi: 10.1016/j.dld.2008.12.095. Epub 2009 Feb 4. Review. PubMed PMID: 19195940.


Leffler DA, Dennis M, Edwards George JB, Jamma S, Magge S, Cook EF, Schuppan D, Kelly CP. A simple validated gluten-free diet adherence survey for adults with
celiac disease. Clin Gastroenterol Hepatol. 2009 May;7(5):530-6, 536.e1-2. doi: 10.1016/j.cgh.2008.12.032. Epub 2009 Jan 11. PubMed PMID: 19268725.


Garud S, Leffler D, Dennis M, Edwards-George J, Saryan D, Sheth S, Schuppan D, Jamma S, Kelly CP. Interaction between psychiatric and autoimmune disorders in
coeliac disease patients in the Northeastern United States. Aliment Pharmacol Ther. 2009 Apr 15;29(8):898-905. doi: 10.1111/j.1365-2036.2009.03942.x. PubMed
PMID: 19183153; PubMed Central PMCID: PMC2763921.


Malik R, Chang M, Bhaskar K, Nasser I, Curry M, Schuppan D, Byrnes V, Afdhal N. The clinical utility of biomarkers and the nonalcoholic steatohepatitis CRN
liver biopsy scoring system in patients with nonalcoholic fatty liver disease. J Gastroenterol Hepatol. 2009 Apr;24(4):564-8. PubMed PMID: 19378390.


Millonig G, Hegedüsch S, Becker L, Seitz HK, Schuppan D, Mueller S. Hypoxia-inducible factor 1 alpha under rapid enzymatic hypoxia: cells sense
decrements of oxygen but not hypoxia per se. Free Radic Biol Med. 2009 Jan 15;46(2):182-91. doi: 10.1016/j.freeradbiomed.2008.09.043. Epub 2008 Nov 1.
PubMed PMID: 19007879.


Rakhimova M, Esslinger B, Schulze-Krebs A, Hahn EG, Schuppan D, Dieterich W. In vitro differentiation of human monocytes into dendritic cells by
peptic-tryptic digest of gliadin is independent of genetic predisposition and the presence of celiac disease. J Clin Immunol. 2009 Jan;29(1):29-37. doi:
10.1007/s10875-008-9228-x. Epub 2008 Aug 12. PubMed PMID: 18696220.


Hopfner M, Schuppan D, Scherubl H. Targeted medical therapy of biliary tract cancer: recent advances and future perspectives. World J Gastroenterol. 2008 Dec
14;14(46):7021-32. Review. PubMed PMID: 19084910; PubMed Central PMCID: PMC2776833.

 

Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair.
Wilson A, Laurenti E, Oser G, van der Wath RC, Blanco-Bose W, Jaworski M, Offner S, Dunant CF, Eshkind L, Bockamp E, Lió P, Macdonald HR, Trumpp A. Cell. 2008 Dec 12;135(6):1118-29. doi: 10.1016/j.cell.2008.10.048. Erratum in: Cell. 2009 Jul 10;138(1):209. PMID:19062086


Omenetti A, Porrello A, Jung Y, Yang L, Popov Y, Choi SS, Witek RP, Alpini G, Venter J, Vandongen HM, Syn WK, Baroni GS, Benedetti A, Schuppan D, Diehl AM.
Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. J Clin Invest. 2008 Oct;118(10):3331-42. doi:
10.1172/JCI35875. PubMed PMID: 18802480; PubMed Central PMCID: PMC2542850.


Omenetti A, Popov Y, Jung Y, Choi SS, Witek RP, Yang L, Brown KD, Schuppan D, Diehl AM. The hedgehog pathway regulates remodelling responses to biliary
obstruction in rats. Gut. 2008 Sep;57(9):1275-82. doi: 10.1136/gut.2008.148619. Epub 2008 Mar 28. PubMed PMID: 18375471.


Patsenker E, Popov Y, Stickel F, Jonczyk A, Goodman SL, Schuppan D. Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth
factor-beta activation and retards biliary fibrosis progression. Gastroenterology. 2008 Aug;135(2):660-70. doi: 10.1053/j.gastro.2008.04.009. Epub
2008 Apr 16. PubMed PMID: 18538673; PubMed Central PMCID: PMC3505071.


Stickel F, Osterreicher CH, Halangk J, Berg T, Homann N, Hellerbrand C, Patsenker E, Schneider V, Kolb A, Friess H, Schuppan D, Puhl G, Seitz HK,
Leathart JL, Day CP. No role of matrixmetalloproteinase-3 genetic promoter polymorphism 1171 as a risk factor for cirrhosis in alcoholic liver disease.
Alcohol Clin Exp Res. 2008 Jun;32(6):959-65. doi: 10.1111/j.1530-0277.2008.00654.x. Epub 2008 Apr 26. PubMed PMID: 18445105.

Leffler DA, Edwards-George J, Dennis M, Schuppan D, Cook F, Franko DL, Blom-Hoffman J, Kelly CP. Factors that influence adherence to a gluten-free diet
in adults with celiac disease. Dig Dis Sci. 2008 Jun;53(6):1573-81. PubMed PMID: 17990115; PubMed Central PMCID: PMC3756800.


Höpfner M, Schuppan D, Scherübl H. Treatment of gastrointestinal neuroendocrine tumors with inhibitors of growth factor receptors and their
signaling pathways: recent advances and future perspectives. World J Gastroenterol. 2008 Apr 28;14(16):2461-73. Review. PubMed PMID: 18442192; PubMed
Central PMCID: PMC2708356.


Schuppan D, Afdhal NH. Liver cirrhosis. Lancet. 2008 Mar 8;371(9615):838-51. doi: 10.1016/S0140-6736(08)60383-9. Review. PubMed PMID: 18328931; PubMed Central
PMCID: PMC2271178.


Popov Y, Patsenker E, Stickel F, Zaks J, Bhaskar KR, Niedobitek G, Kolb A, Friess H, Schuppan D. Integrin alphavbeta6 is a marker of the progression of
biliary and portal liver fibrosis and a novel target for antifibrotic therapies. J Hepatol. 2008 Mar;48(3):453-64. doi: 10.1016/j.jhep.2007.11.021. Epub 2008 Jan
14. PubMed PMID: 18221819.


Schuppan D, Kelly CP. Is duodenal biopsy required in all patients with suspected celiac disease? Nat Clin Pract Gastroenterol Hepatol. 2008
Feb;5(2):70-1. Epub 2007 Nov 27. PubMed PMID: 18043590.

 
Höpfner M, Schuppan D, Scherübl H. Growth factor receptors and related signalling pathways as targets for novel treatment strategies of hepatocellular
cancer. World J Gastroenterol. 2008 Jan 7;14(1):1-14. Review. PubMed PMID: 18176955; PubMed Central PMCID: PMC2673371.


Künzli BM, Nuhn P, Enjyoji K, Banz Y, Smith RN, Csizmadia E, Schuppan D, Berberat PO, Friess H, Robson SC. Disordered pancreatic inflammatory responses
and inhibition of fibrosis in CD39-null mice. Gastroenterology. 2008 Jan;134(1):292-305. Epub 2007 Oct 25. PubMed PMID: 18036594; PubMed Central
PMCID: PMC2189558.


Leffler DA, Edwards George JB, Dennis M, Cook EF, Schuppan D, Kelly CP. A prospective comparative study of five measures of gluten-free diet adherence in
adults with coeliac disease. Aliment Pharmacol Ther. 2007 Nov 1;26(9):1227-35. PubMed PMID: 17944737.


Dieterich W, Schuppan D. Is gliadin harmful from the first morsel? Dig Liver Dis. 2007 Oct;39(10):917-21. Epub 2007 Aug 27. Review. PubMed PMID: 17720638.


Baradari V, Höpfner M, Huether A, Schuppan D, Scherübl H. Histone deacetylase inhibitor MS-275 alone or combined with bortezomib or sorafenib
exhibits strong antiproliferative action in human cholangiocarcinoma cells. World J Gastroenterol. 2007 Sep 7;13(33):4458-66. PubMed PMID: 17724801; PubMed Central
PMCID: PMC4611578.


Schuppan D, Junker Y. Turning swords into plowshares: transglutaminase to
detoxify gluten. Gastroenterology. 2007 Sep;133(3):1025-8. PubMed PMID: 17854603.


Huether A, Höpfner M, Baradari V, Schuppan D, Scherübl H. Sorafenib alone or as combination therapy for growth control of cholangiocarcinoma. Biochem
Pharmacol. 2007 May 1;73(9):1308-17. Epub 2007 Jan 5. PubMed PMID: 17266941.


Patsenker E, Popov Y, Wiesner M, Goodman SL, Schuppan D. Pharmacological inhibition of the vitronectin receptor abrogates PDGF-BB-induced hepatic stellate
cell migration and activation in vitro. J Hepatol. 2007 May;46(5):878-87. Epub 2006 Dec 12. PubMed PMID: 17258347.


Leffler DA, Dennis M, Hyett B, Kelly E, Schuppan D, Kelly CP. Etiologies and predictors of diagnosis in nonresponsive celiac disease. Clin Gastroenterol
Hepatol. 2007 Apr;5(4):445-50. Epub 2007 Mar 26. PubMed PMID: 17382600.


Stickel F, Schuppan D. Herbal medicine in the treatment of liver diseases. Dig Liver Dis. 2007 Apr;39(4):293-304. Epub 2007 Feb 28. Review. PubMed PMID:
17331820.


Rost D, Welker A, Welker J, Millonig G, Berger I, Autschbach F, Schuppan D, Mueller S. Liver-homing of purified glucose oxidase: a novel in vivo model of
physiological hepatic oxidative stress (H2O2). J Hepatol. 2007 Mar;46(3):482-91. Epub 2006 Nov 17. PubMed PMID: 17188390.


Isbert C, Ritz JP, Roggan A, Schuppan D, Ajubi N, Buhr HJ, Hohenberger W, Germer CT. Laser-induced thermotherapy (LITT) elevates mRNA expression of
connective tissue growth factor (CTGF) associated with reduced tumor growth of liver metastases compared to hepatic resection. Lasers Surg Med. 2007
Jan;39(1):42-50. PubMed PMID: 17111416.


Baradari V, Huether A, Höpfner M, Schuppan D, Scherübl H. Antiproliferative and proapoptotic effects of histone deacetylase inhibitors on gastrointestinal
neuroendocrine tumor cells. Endocr Relat Cancer. 2006 Dec;13(4):1237-50. PubMed PMID: 17158768.


Koda M, Bauer M, Krebs A, Hahn EG, Schuppan D, Murawaki Y. Endothelin-1 enhances fibrogenic gene expression, but does not promote DNA synthesis or
apoptosis in hepatic stellate cells. Comp Hepatol. 2006 Oct 24;5:5. PubMed PMID: 17062135; PubMed Central PMCID: PMC1635728.


Daum S, Foss HD, Schuppan D, Riecken EO, Zeitz M, Ullrich R. Synthesis of collagen I in collagenous sprue. Clin Gastroenterol Hepatol. 2006
Oct;4(10):1232-6. Epub 2006 Sep 18. PubMed PMID: 16979955.


Joos S, Wildau N, Kohnen R, Szecsenyi J, Schuppan D, Willich SN, Hahn EG, Brinkhaus B. Acupuncture and moxibustion in the treatment of ulcerative colitis:
a randomized controlled study. Scand J Gastroenterol. 2006 Sep;41(9):1056-63.
PubMed PMID: 16938719.


Huether A, Hopfner M, Sutter AP, Baradari V, Schuppan D, Scherubl H. Signaling pathways involved in the inhibition of epidermal growth factor receptor
by erlotinib in hepatocellular cancer. World J Gastroenterol. 2006 Aug 28;12(32):5160-7. PubMed PMID: 16937526; PubMed Central PMCID: PMC4088013.


Schurr R, Stölzel U, Schuppan D, Schwertner C, Steinberg J, Scherübl H. [Increased incidence of hepatocellular and intrahepatic cholangiocellular
carcinoma in northeast Germany]. Dtsch Med Wochenschr. 2006 Jul 28;131(30):1649-55. German. PubMed PMID: 16850381.


Schuppan D, Kelly CP, Krauss N. Monitoring non-responsive patients with celiac disease. Gastrointest Endosc Clin N Am. 2006 Jul;16(3):593-603. Review.
PubMed PMID: 16876729.


Hansler J, Wissniowski TT, Schuppan D, Witte A, Bernatik T, Hahn EG, Strobel D. Activation and dramatically increased cytolytic activity of tumor specific T
lymphocytes after radio-frequency ablation in patients with hepatocellular carcinoma and colorectal liver metastases. World J Gastroenterol. 2006 Jun
21;12(23):3716-21. PubMed PMID: 16773688; PubMed Central PMCID: PMC4087464.


Lebensztejn DM, Sobaniec-Lotowska ME, Kaczmarski M, Voelker M, Schuppan D. Matrix-derived serum markers in monitoring liver fibrosis in children with
chronic hepatitis B treated with interferon alpha. World J Gastroenterol. 2006 Jun 7;12(21):3338-43. PubMed PMID: 16733849; PubMed Central PMCID: PMC4087863.


Popov Y, Patsenker E, Bauer M, Niedobitek E, Schulze-Krebs A, Schuppan D. Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via
activation of p38 and NFkappaB. J Biol Chem. 2006 Jun 2;281(22):15090-8. Epub 2006 Feb 17. PubMed PMID: 16489207.


Mueller S, Afdhal NH, Schuppan D. Iron, HCV, and liver cancer: hard metal setting the pace? Gastroenterology. 2006 Jun;130(7):2229-34. PubMed PMID:
16762645.


Jürgensen C, Schuppan D, Neser F, Ernstberger J, Junghans U, Stölzel U. EUS-guided alcohol ablation of an insulinoma. Gastrointest Endosc. 2006
Jun;63(7):1059-62. PubMed PMID: 16733126.


Strnad P, Lienau TC, Tao GZ, Lazzeroni LC, Stickel F, Schuppan D, Omary MB. Keratin variants associate with progression of fibrosis during chronic hepatitis
C infection. Hepatology. 2006 Jun;43(6):1354-63. PubMed PMID: 16729313.


Höpfner M, Huether A, Sutter AP, Baradari V, Schuppan D, Scherübl H. Blockade of IGF-1 receptor tyrosine kinase has antineoplastic effects in
hepatocellular carcinoma cells. Biochem Pharmacol. 2006 May 14;71(10):1435-48. Epub 2006 Mar 10. PubMed PMID: 16530734.


Homann N, Stickel F, König IR, Jacobs A, Junghanns K, Benesova M, Schuppan D, Himsel S, Zuber-Jerger I, Hellerbrand C, Ludwig D, Caselmann WH, Seitz HK.
Alcohol dehydrogenase 1C*1 allele is a genetic marker for alcohol-associated cancer in heavy drinkers. Int J Cancer. 2006 Apr 15;118(8):1998-2002. PubMed
PMID: 16287084.


Krauss N, Schuppan D. Monitoring nonresponsive patients who have celiac disease. Gastrointest Endosc Clin N Am. 2006 Apr;16(2):317-27. Review. Erratum
in: Gastrointest Endosc Clin N Am. 2006 Jul;16(3):xi. PubMed PMID: 16644460.


Dieterich W, Esslinger B, Trapp D, Hahn E, Huff T, Seilmeier W, Wieser H, Schuppan D. Cross linking to tissue transglutaminase and collagen favours gliadin
toxicity in coeliac disease. Gut. 2006 Apr;55(4):478-84. Epub 2005 Sep 27. PubMed PMID: 16188922; PubMed Central PMCID: PMC1856150.


Teubner A, Richter M, Schuppan D, Köstler E, Stölzel U. [Hepatitis C, hemochromatosis and porphyria cutanea tarda]. Dtsch Med Wochenschr. 2006 Mar
31;131(13):691-5. Review. German. PubMed PMID: 16555178.


Pavel ME, Hoppe S, Papadopoulos T, Linder V, Mohr B, Hahn EG, Lohmann T, Schuppan D. Adrenomedullin is a novel marker of tumor progression in
neuroendocrine carcinomas. Horm Metab Res. 2006 Feb;38(2):112-8. PubMed PMID: 16523412.


Lohwasser C, Neureiter D, Weigle B, Kirchner T, Schuppan D. The receptor for advanced glycation end products is highly expressed in the skin and upregulated
by advanced glycation end products and tumor necrosis factor-alpha. J Invest Dermatol. 2006 Feb;126(2):291-9. PubMed PMID: 16374460.


Metzger MH, Heier M, Mäki M, Bravi E, Schneider A, Löwel H, Illig T, Schuppan D, Wichmann HE. Mortality excess in individuals with elevated IgA
anti-transglutaminase antibodies: the KORA/MONICA Augsburg cohort study 1989-1998. Eur J Epidemiol. 2006;21(5):359-65. Epub 2006 Apr 29. PubMed PMID:16649072.


Pavel ME, Baum U, Hahn EG, Schuppan D, Lohmann T. Efficacy and tolerability of pegylated IFN-alpha in patients with neuroendocrine gastroenteropancreatic
carcinomas. J Interferon Cytokine Res. 2006 Jan;26(1):8-13. PubMed PMID: 16426143.


Konturek PC, Bazela K, Kukharskyy V, Bauer M, Hahn EG, Schuppan D. Helicobacter pylori upregulates prion protein expression in gastric mucosa: a
possible link to prion disease. World J Gastroenterol. 2005 Dec 28;11(48):7651-6.PubMed PMID: 16437693; PubMed Central PMCID: PMC4727223.


Popov Y, Patsenker E, Fickert P, Trauner M, Schuppan D. Mdr2 (Abcb4)-/- mice spontaneously develop severe biliary fibrosis via massive dysregulation of pro-
and antifibrogenic genes. J Hepatol. 2005 Dec;43(6):1045-54. Epub 2005 Aug 15. PubMed PMID: 16223543.


Huether A, Höpfner M, Baradari V, Schuppan D, Scherübl H. EGFR blockade by cetuximab alone or as combination therapy for growth control of hepatocellular
cancer. Biochem Pharmacol. 2005 Nov 25;70(11):1568-78. Epub 2005 Oct 13. PubMed PMID: 16226226.


Ruehl M, Erben U, Schuppan D, Wagner C, Zeller A, Freise C, Al-Hasani H, Loesekann M, Notter M, Wittig BM, Zeitz M, Dieterich W, Somasundaram R. The
elongated first fibronectin type III domain of collagen XIV is an inducer of quiescence and differentiation in fibroblasts and preadipocytes. J Biol Chem.
2005 Nov 18;280(46):38537-43. Epub 2005 Aug 29. PubMed PMID: 16129687.


Benten D, Kumaran V, Joseph B, Schattenberg J, Popov Y, Schuppan D, Gupta S.Hepatocyte transplantation activates hepatic stellate cells with beneficial
modulation of cell engraftment in the rat. Hepatology. 2005 Nov;42(5):1072-81. PubMed PMID: 16250034.


Stickel F, Patsenker E, Schuppan D. Herbal hepatotoxicity. J Hepatol. 2005
Nov;43(5):901-10. Epub 2005 Aug 25. Review. PubMed PMID: 16171893.


Sutter AP, Maaser K, Höpfner M, Huether A, Schuppan D, Scherübl H. Cell cycle arrest and apoptosis induction in hepatocellular carcinoma cells by HMG-CoA
reductase inhibitors. Synergistic antiproliferative action with ligands of the peripheral benzodiazepine receptor. J Hepatol. 2005 Nov;43(5):808-16. Epub 2005
May 31. PubMed PMID: 16083991.


Huether A, Höpfner M, Sutter AP, Schuppan D, Scherübl H. Erlotinib induces cell cycle arrest and apoptosis in hepatocellular cancer cells and enhances
chemosensitivity towards cytostatics. J Hepatol. 2005 Oct;43(4):661-9. PubMed PMID: 16023762.


Stickel F, Osterreicher CH, Datz C, Ferenci P, Wölfel M, Norgauer W, Kraus MR, Wrba F, Hellerbrand C, Schuppan D. Prediction of progression to cirrhosis by
a glutathione S-transferase P1 polymorphism in subjects with hereditary hemochromatosis. Arch Intern Med. 2005 Sep 12;165(16):1835-40.
PubMed PMID: 16157826. 


Li ZD, Bork JP, Krueger B, Patsenker E, Schulze-Krebs A, Hahn EG, Schuppan D. VEGF induces proliferation, migration, and TGF-beta1 expression in mouse
glomerular endothelial cells via mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Biochem Biophys Res Commun. 2005 Sep
9;334(4):1049-60. PubMed PMID: 16039615.


Ocker M, Neureiter D, Lueders M, Zopf S, Ganslmayer M, Hahn EG, Herold C, Schuppan D. Variants of bcl-2 specific siRNA for silencing antiapoptotic bcl-2 in
pancreatic cancer. Gut. 2005 Sep;54(9):1298-308. PubMed PMID: 16099798; PubMed Central PMCID: PMC1774673.


Reis RC, Schuppan D, Barreto AC, Bauer M, Bork JP, Hassler G, Coelho-Sampaio T. Endostatin competes with bFGF for binding to heparin-like glycosaminoglycans.
Biochem Biophys Res Commun. 2005 Aug 5;333(3):976-83. PubMed PMID: 15985216.


Lebensztejn DM, Sobaniec-Łotowska ME, Bauer M, Kaczmarski M, Voelker M, Schuppan D. Serum fibrosis markers as predictors of an antifibrotic effect of
interferon alfa in children with chronic hepatitis B. Eur J Gastroenterol Hepatol. 2005 Aug;17(8):843-8. PubMed PMID: 16003134.


Yedibela S, Schuppan D, Müller V, Schellerer V, Tannapfel A, Hohenberger W, Meyer T. Successful treatment of hepatitis C reinfection with interferon-alpha2b
and ribavirin after liver transplantation. Liver Int. 2005 Aug;25(4):717-22. PubMed PMID: 15998420.

 
Osterreicher CH, Datz C, Stickel F, Hellerbrand C, Penz M, Hofer H, Wrba F, Penner E, Schuppan D, Ferenci P. TGF-beta1 codon 25 gene polymorphism is
associated with cirrhosis in patients with hereditary hemochromatosis. Cytokine. 2005 Jul 21;31(2):142-8. PubMed PMID: 15941661.


Schulze-Krebs A, Preimel D, Popov Y, Bartenschlager R, Lohmann V, Pinzani M, Schuppan D. Hepatitis C virus-replicating hepatocytes induce fibrogenic
activation of hepatic stellate cells. Gastroenterology. 2005 Jul;129(1):246-58. PubMed PMID: 16012951.


Koning F, Schuppan D, Cerf-Bensussan N, Sollid LM. Pathomechanisms in celiac disease. Best Pract Res Clin Gastroenterol. 2005 Jun;19(3):373-87. Review. PubMed
PMID: 15925843.


Ocker M, Alajati A, Ganslmayer M, Zopf S, Lüders M, Neureiter D, Hahn EG, Schuppan D, Herold C. The histone-deacetylase inhibitor SAHA potentiates
proapoptotic effects of 5-fluorouracil and irinotecan in hepatoma cells. J Cancer Res Clin Oncol. 2005 Jun;131(6):385-94. Epub 2005 Mar 8. PubMed PMID: 15754201.


Osterreicher CH, Datz C, Stickel F, Hellerbrand C, Penz M, Hofer H, Wrba F, Penner E, Schuppan D, Ferenci P. Association of myeloperoxidase promotor
polymorphism with cirrhosis in patients with hereditary hemochromatosis. J Hepatol. 2005 Jun;42(6):914-9. Epub 2005 Apr 2. PubMed PMID: 15885363.


Dan Z, Popov Y, Patsenker E, Preimel D, Liu C, Wang XD, Seitz HK, Schuppan D, Stickel F. Hepatotoxicity of alcohol-induced polar retinol metabolites
involves apoptosis via loss of mitochondrial membrane potential. FASEB J. 2005 May;19(7):845-7. Epub 2005 Feb 24. PubMed PMID: 15731294.


Ganslmayer M, Ocker M, Zopf S, Schuppan D, Hahn EG, Herold C. Hepatocellular carcinomas do not compromise quantitative tests of liver function.
Hepatogastroenterology. 2005 May-Jun;52(63):881-4. PubMed PMID: 15966225.


Pavel ME, Hassler G, Baum U, Hahn EG, Lohmann T, Schuppan D. Circulating levels of angiogenic cytokines can predict tumour progression and prognosis in
neuroendocrine carcinomas. Clin Endocrinol (Oxf). 2005 Apr;62(4):434-43. PubMed PMID: 15807874.


Graepler F, Verbeek B, Graeter T, Smirnow I, Kong HL, Schuppan D, Bauer M, Vonthein R, Gregor M, Lauer UM. Combined endostatin/sFlt-1 antiangiogenic gene
therapy is highly effective in a rat model of HCC. Hepatology. 2005 Apr;41(4):879-86. PubMed PMID: 15739185.


Schuppan D, Dennis MD, Kelly CP. Celiac disease: epidemiology, pathogenesis, diagnosis, and nutritional management. Nutr Clin Care. 2005 Apr-Jun;8(2):54-69.
Review. PubMed PMID: 16013224.

 

 

2004-2000

von Moers A, Zwirner A, Reinhold A, Brückmann O, van Landeghem F, Stoltenburg-Didinger G, Schuppan D, Herbst H, Schuelke M. Increased mRNA
expression of tissue inhibitors of metalloproteinase-1 and -2 in Duchenne muscular dystrophy. Acta Neuropathol. 2005 Mar;109(3):285-93. Epub 2004 Dec 23.PubMed PMID: 15616792.

Ciccocioppo R, Di Sabatino A, Bauer M, Della Riccia DN, Bizzini F, Biagi F, Cifone MG, Corazza GR, Schuppan D. Matrix metalloproteinase pattern in celiac
duodenal mucosa. Lab Invest. 2005 Mar;85(3):397-407. PubMed PMID: 15608660.

Rosenberg WM, Voelker M, Thiel R, Becka M, Burt A, Schuppan D, Hubscher S,Roskams T, Pinzani M, Arthur MJ; European Liver Fibrosis Group. Serum markers
detect the presence of liver fibrosis: a cohort study. Gastroenterology. 2004 Dec;127(6):1704-13. PubMed PMID: 15578508.

Höpfner M, Sutter AP, Huether A, Schuppan D, Zeitz M, Scherübl H. Targeting the epidermal growth factor receptor by gefitinib for treatment of hepatocellular
carcinoma. J Hepatol. 2004 Dec;41(6):1008-16. PubMed PMID: 15582135.

Sutter AP, Maaser K, Grabowski P, Bradacs G, Vormbrock K, Höpfner M, KrahnA, Heine B, Stein H, Somasundaram R, Schuppan D, Zeitz M, Scherübl H. Peripheral
benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel,
docetaxel, doxorubicin and the Bcl-2 inhibitor HA14-1. J Hepatol. 2004 Nov;41(5):799-807. PubMed PMID: 15519653.

Freitag T, Schuppan D. Screening for coeliac disease antigen source and performance of the anti-tissue transglutaminase ELISA. Dig Liver Dis. 2004
Oct;36(10):658-60. PubMed PMID: 15506663.

Stölzel U, Teubner A, Ernstberger J, Habeck JO, Schuppan D. Isolated elevation of gGT: what should be the diagnostic approach? Dtsch Med Wochenschr.
2004 Sep 3;129 Suppl 2:S54-6. PubMed PMID: 15368168.

Brinkhaus B, Hummelsberger J, Kohnen R, Seufert J, Hempen CH, Leonhardy H,Nögel R, Joos S, Hahn E, Schuppan D. Acupuncture and Chinese herbal medicine in
the treatment of patients with seasonal allergic rhinitis: arandomized-controlled clinical trial. Allergy. 2004 Sep;59(9):953-60. PubMedPMID: 15291903.

Cramer T, Schuppan D, Bauer M, Pfander D, Neuhaus P, Herbst H. Hepatocyte growth factor and c-Met expression in rat and human liver fibrosis. Liver Int.
2004 Aug;24(4):335-44. PubMed PMID: 15287857.

Ganslmayer M, Ocker M, Kraemer G, Zopf S, Hahn EG, Schuppan D, Herold C. Thecombination of tamoxifen and 9cis retinoic acid exerts overadditive anti-tumoral
efficacy in rat hepatocellular carcinoma. J Hepatol. 2004 Jun;40(6):952-6. PubMed PMID: 15158335.

Ocker M, Herold C, Ganslmayer M, Zopf S, Hahn EG, Schuppan D. Potentiated anticancer effects on hepatoma cells by the retinoid adapalene. Cancer Lett. 2004
May 10;208(1):51-8. PubMed PMID: 15105045.

Schuppan D, Freitag T. Fistulising Crohn's disease: MMPs gone awry. Gut.2004 May;53(5):622-4. Review. PubMed PMID: 15082575; PubMed Central PMCID:PMC1774058.

Ganslmayer M, Ocker M, Zopf S, Leitner S, Hahn EG, Schuppan D, Herold C. A quadruple therapy synergistically blocks proliferation and promotes apoptosis of
hepatoma cells. Oncol Rep. 2004 May;11(5):943-50. PubMed PMID: 15069530.

Lebensztejn DM, Kaczmarski M, Sobaniec-Lotowska M, Bauer M, Voelker M,Schuppan D. Serum laminin-2 and hyaluronan predict severe liver fibrosis in
children with chronic hepatitis B. Hepatology. 2004 Mar;39(3):868-9. PubMed PMID:14999715.

Freitag T, Schulze-Koops H, Niedobitek G, Melino G, Schuppan D. The role of the immune response against tissue transglutaminase in the pathogenesis of
coeliac disease. Autoimmun Rev. 2004 Feb;3(2):13-20. Review. PubMed PMID:15003183.

Calabrò A, Grappone C, Pellegrini G, Evangelista S, Tramontana M, SchuppanD, Herbst H, Milani S. Spatial and temporal pattern of expression of interstitial
collagenase, stromelysin/transin, gelatinase A, and TIMP-1 during experimentalgastric ulcer healing. Digestion. 2004;70(2):127-38. Epub 2004 Sep 16. PubMed PMID: 15375341.

Joos S, Brinkhaus B, Maluche C, Maupai N, Kohnen R, Kraehmer N, Hahn EG,Schuppan D. Acupuncture and moxibustion in the treatment of active Crohn's
disease: a randomized controlled study. Digestion. 2004;69(3):131-9. Epub 2004 Apr 26. PubMed PMID: 15114043.

Hellemans K, Verbuyst P, Quartier E, Schuit F, Rombouts K, Chandraratna RA, Schuppan D, Geerts A. Differential modulation of rat hepatic stellate phenotype
by natural and synthetic retinoids. Hepatology. 2004 Jan;39(1):97-108. PubMed PMID: 14752828.

Sellge G, Lorentz A, Gebhardt T, Levi-Schaffer F, Bektas H, Manns MP,Schuppan D, Bischoff SC. Human intestinal fibroblasts prevent apoptosis in human
intestinal mast cells by a mechanism independent of stem cell factor, IL-3, IL-4,and nerve growth factor. J Immunol. 2004 Jan 1;172(1):260-7. PubMed PMID:14688333.

Isbert C, Ritz JP, Roggan A, Schuppan D, Rühl M, Buhr HJ, Germer CT.Enhancement of the immune response to residual intrahepatic tumor tissue by
laser-induced thermotherapy (LITT) compared to hepatic resection. Lasers SurgMed. 2004;35(4):284-92. PubMed PMID: 15493028.

Ocker M, Herold C, Ganslmayer M, Hahn EG, Schuppan D. The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells
in vitro. Int J Cancer. 2003 Nov 10;107(3):453-9. PubMed PMID: 14506747.

Dieterich W, Trapp D, Esslinger B, Leidenberger M, Piper J, Hahn E, SchuppanD. Autoantibodies of patients with coeliac disease are insufficient to block
tissue transglutaminase activity. Gut. 2003 Nov;52(11):1562-6. PubMed PMID:14570723; PubMed Central PMCID: PMC1773855.

Wissniowski TT, Hänsler J, Neureiter D, Frieser M, Schaber S, Esslinger B,Voll R, Strobel D, Hahn EG, Schuppan D. Activation of tumor-specific T
lymphocytes by radio-frequency ablation of the VX2 hepatoma in rabbits. CancerRes. 2003 Oct 1;63(19):6496-500. Erratum in: Cancer Res. 2003 Nov 1;63(21):7543.
Wissniowski, Thadäus Till [corrected to Wissniowski, Thaddäus Till]; Hünsler,Johannes [corrected to Hänsler, Johannes]. PubMed PMID: 14559842.

Dieterich W, Esslinger B, Schuppan D. Pathomechanisms in celiac disease. IntArch Allergy Immunol. 2003 Oct;132(2):98-108. Review. PubMed PMID: 14600421.

Stickel F, Poeschl G, Schuppan D, Conradt C, Strenge-Hesse A, Fuchs FS,Hofmann WJ, Seitz HK. Serum hyaluronate correlates with histological progression
in alcoholic liver disease. Eur J Gastroenterol Hepatol. 2003 Sep;15(9):945-50.PubMed PMID: 12923365.

Herold C, Ganslmayer M, Ocker M, Blauberger S, Zopf S, Hahn EG, Schuppan D. Overadditive anti-proliferative and pro-apoptotic effects of a combination
therapy on colorectal carcinoma cells. Int J Oncol. 2003 Sep;23(3):751-6. PubMed PMID: 12888913.

Stickel F, Hoehn B, Schuppan D, Seitz HK. Review article: Nutritional therapy in alcoholic liver disease. Aliment Pharmacol Ther. 2003 Aug
15;18(4):357-73. Review. PubMed PMID: 12940921.

Schuppan D, Ocker M. Integrin-mediated control of cell growth. Hepatology.2003 Aug;38(2):289-91. Review. PubMed PMID: 12883471.

Pender SL, Braegger C, Gunther U, Monteleone G, Meuli M, Schuppan D,Macdonald TT. Matrix metalloproteinases in necrotising enterocolitis. Pediatr
Res. 2003 Aug;54(2):160-4. Epub 2003 May 7. PubMed PMID: 12736398.

Stickel F, Seitz HK, Schuppan D. [Review "Kava, kavapyrones and toxic liver injury" by R Teschke, Hanau Zeitschrift für Gastroenterologie 2003, 41:395-404].
Z Gastroenterol. 2003 Aug;41(8):888-9. German. PubMed PMID: 12910431.

Schuppan D, Esslinger B, Dieterich W. Innate immunity and coeliac disease.Lancet. 2003 Jul 5;362(9377):3-4. PubMed PMID: 12853189.

Stickel F, Baumüller HM, Seitz K, Vasilakis D, Seitz G, Seitz HK, SchuppanD. Hepatitis induced by Kava (Piper methysticum rhizoma). J Hepatol. 2003
Jul;39(1):62-7. PubMed PMID: 12821045.

Zeitlin L, Resnick MB, Konikoff F, Schuppan D, Bujanover Y, Lerner A, BelsonA, Lifschitz B, Reif S. Divergent patterns of extracellular matrix protein
expression in neonatal versus adult liver fibrosis. Pediatr Pathol Mol Med. 2003 Jul-Aug;22(4):349-62. PubMed PMID: 14692230.

Schuppan D, Esslinger B. [Endemic sprue (celiac disease)--diagnosis,associated diseases and therapy]. Dtsch Med Wochenschr. 2003 Jun 13;128 Suppl
2:S69-71. Review. German. PubMed PMID: 12817326.

Schaefer B, Rivas-Estilla AM, Meraz-Cruz N, Reyes-Romero MA,Hernández-Nazara ZH, Domínguez-Rosales JA, Schuppan D, Greenwel P, Rojkind M.
Reciprocal modulation of matrix metalloproteinase-13 and type I collagen genes inrat hepatic stellate cells. Am J Pathol. 2003 Jun;162(6):1771-80. PubMed PMID:12759235; PubMed Central PMCID: PMC1868138.

Rombouts K, Kisanga E, Hellemans K, Wielant A, Schuppan D, Geerts A. Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat
hepatic stellate cells. J Hepatol. 2003 May;38(5):564-72. PubMed PMID: 12713866.

Stickel F, Pöschl G, Seitz HK, Waldherr R, Hahn EG, Schuppan D. Acute hepatitis induced by Greater Celandine (Chelidonium majus). Scand J
Gastroenterol. 2003 May;38(5):565-8. PubMed PMID: 12795472.

Hanke B, Wein A, Martus P, Riedel C, Voelker M, Hahn EG, Schuppan D. Serummarkers of matrix turnover as predictors for the evolution of colorectal cancer
metastasis under chemotherapy. Br J Cancer. 2003 Apr 22;88(8):1248-50. PubMedPMID: 12698191; PubMed Central PMCID: PMC2747566.

Herold C, Ganslmayer M, Ocker M, Zopf S, Gailer B, Hahn EG, Schuppan D.Inducibility of microsomal liver function may differentiate cirrhotic patients
with maintained compared with severely compromised liver reserve. J GastroenterolHepatol. 2003 Apr;18(4):445-9. PubMed PMID: 12653894.

Tilg H, Jalan R, Kaser A, Davies NA, Offner FA, Hodges SJ, Ludwiczek O,Shawcross D, Zoller H, Alisa A, Mookerjee RP, Graziadei I, Datz C, Trauner M,
Schuppan D, Obrist P, Vogel W, Williams R. Anti-tumor necrosis factor-alphamonoclonal antibody therapy in severe alcoholic hepatitis. J Hepatol. 2003
Apr;38(4):419-25. PubMed PMID: 12663232.

Stickel F, Seitz HK, Hahn EG, Schuppan D. [Alcoholic liver disease--established treatment and new therapeutic approaches]. Z Gastroenterol.
2003 Apr;41(4):333-42. Review. German. PubMed PMID: 12695940.

Sedlaczek N, Hasilik A, Neuhaus P, Schuppan D, Herbst H. Focaloverexpression of insulin-like growth factor 2 by hepatocytes and cholangiocytes
in viral liver cirrhosis. Br J Cancer. 2003 Mar 10;88(5):733-9. PubMed PMID:12618883; PubMed Central PMCID: PMC2376349.

Stölzel U, Köstler E, Schuppan D, Richter M, Wollina U, Doss MO, Wittekind C, Tannapfel A. Hemochromatosis (HFE) gene mutations and response to chloroquine
in porphyria cutanea tarda. Arch Dermatol. 2003 Mar;139(3):309-13. PubMed PMID:12622622.

Schuppan D, Dieterich W. A molecular warhead and its target: tissuetransglutaminase and Celiac Sprue. Chem Biol. 2003 Mar;10(3):199-201. PubMedPMID: 12670530.

Ott R, Schuppan D, Tannapfel A, Wittekind C, Erhardt W, Henke J, Kilic N,Köckerling F, Reck T, Hohenberger W, Müller V. Portal vein arterialisation as a
technical option in liver transplantation: impact on function, regeneration, and morphology of the liver following hemihepatectomy in pigs. Liver Int. 2003
Feb;23(1):54-62. PubMed PMID: 12640728.

Schuppan D, Krebs A, Bauer M, Hahn EG. Hepatitis C and liver fibrosis. Cell Death Differ. 2003 Jan;10 Suppl 1:S59-67. Review. PubMed PMID: 12655347.

Herold C, Regn S, Ganslmayer M, Ocker M, Hahn EG, Schuppan D. Can quantitative tests of liver function discriminate between different etiologies of
liver cirrhosis? Dig Dis Sci. 2002 Dec;47(12):2669-73. PubMed PMID: 12498283.

Schuppan D, Popov Y. Hepatic fibrosis: from bench to bedside. JGastroenterol Hepatol. 2002 Dec;17 Suppl 3:S300-5. Review. Erratum in: J
Gastroenterol Hepatol. 2008 Sep;23(9):1464. Porov, Yury [corrected to Popov,Yury]. PubMed PMID: 12472954.

Teubner A, Tillmann HL, Schuppan D, Gericke G, Manns MP, Stölzel U.[Prevalence of circulating autoantibodies in healthy individuals]. Med Klin
(Munich). 2002 Nov 15;97(11):645-9. German. PubMed PMID: 12434272.

Isbert C, Boerner A, Ritz JP, Schuppan D, Buhr HJ, Germer CT. In situablation of experimental liver metastases delays and reduces residual
intrahepatic tumour growth and peritoneal tumour spread compared with hepaticresection. Br J Surg. 2002 Oct;89(10):1252-9. PubMed PMID: 12296892.

Schuppan D, Hahn EG. Biomedicine. Gluten and the gut-lessons for immuneregulation. Science. 2002 Sep 27;297(5590):2218-20. PubMed PMID: 12351776.

Rombouts K, Niki T, Greenwel P, Vandermonde A, Wielant A, Hellemans K, De Bleser P, Yoshida M, Schuppan D, Rojkind M, Geerts A. Trichostatin A, a histone
deacetylase inhibitor, suppresses collagen synthesis and preventsTGF-beta(1)-induced fibrogenesis in skin fibroblasts. Exp Cell Res. 2002 Aug15;278(2):184-97. PubMed PMID: 12169274.

Ruehl M, Somasundaram R, Schoenfelder I, Farndale RW, Knight CG, Schmid M,Ackermann R, Riecken EO, Zeitz M, Schuppan D. The epithelial mitogen keratinocyte
growth factor binds to collagens via the consensus sequenceglycine-proline-hydroxyproline. J Biol Chem. 2002 Jul 26;277(30):26872-8. Epub2002 Apr 24. PubMed PMID: 11973338.

Stickel F, Schuppan D, Hahn EG, Seitz HK. Cocarcinogenic effects of alcohol in hepatocarcinogenesis. Gut. 2002 Jul;51(1):132-9. Review. PubMed PMID:12077107; PubMed Central PMCID: PMC1773267.

Stickel F, Brinkhaus B, Krähmer N, Seitz HK, Hahn EG, Schuppan D.Antifibrotic properties of botanicals in chronic liver disease.
Hepatogastroenterology. 2002 Jul-Aug;49(46):1102-8. Review. PubMed PMID:12143213.

Herold C, Wehler M, Schuppan D, Hahn EG, Strauss R. Changes in hepaticperfusion after administration of hydroxyethyl starch in intensive care patients
assessed using color-coded Doppler sonography. Clin Imaging. 2002May-Jun;26(3):173-6. PubMed PMID: 11983469.

Herold C, Ganslmayer M, Deynet C, Hahn EG, Schuppan D. Quantitative testing of liver function compared to prognostic scores in patients with primary biliary
cirrhosis. Liver. 2002 Apr;22(2):159-65. PubMed PMID: 12028411.

Lorentz A, Schuppan D, Gebert A, Manns MP, Bischoff SC. Regulatory effectsof stem cell factor and interleukin-4 on adhesion of human mast cells to
extracellular matrix proteins. Blood. 2002 Feb 1;99(3):966-72. PubMed PMID:11807000.

Herold C, Ocker M, Ganslmayer M, Gerauer H, Hahn EG, Schuppan D.Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal
carcinoma cells. Br J Cancer. 2002 Feb 1;86(3):443-8. PubMed PMID: 11875713;PubMed Central PMCID: PMC2375221.

Stölzel U, Schuppan D, Tillmann HL, Manns MP, Tannapfel A, Doss MO, ZimmerT, Köstler E. Autoimmunity and HCV infection in porphyria cutanea tarda: a controlled study.
Cell Mol Biol (Noisy-le-grand). 2002 Feb;48(1):43-7. PubMedPMID: 11929046.

Raetsch C, Jia JD, Boigk G, Bauer M, Hahn EG, Riecken EO, Schuppan D.Pentoxifylline downregulates profibrogenic cytokines and procollagen I expression
in rat secondary biliary fibrosis. Gut. 2002 Feb;50(2):241-7. PubMed PMID:11788567; PubMed Central PMCID: PMC1773098.

Somasundaram R, Ruehl M, Schaefer B, Schmid M, Ackermann R, Riecken EO,Zeitz M, Schuppan D. Interstitial collagens I, III, and VI sequester and modulate
the multifunctional cytokine oncostatin M. J Biol Chem. 2002 Feb 1;277(5):3242-6.Epub 2001 Nov 15. PubMed PMID: 11711546.

Herold C, Ganslmayer M, Ocker M, Hermann M, Geerts A, Hahn EG, Schuppan D.The histone-deacetylase inhibitor Trichostatin A blocks proliferation and
triggers apoptotic programs in hepatoma cells. J Hepatol. 2002 Feb;36(2):233-40. PubMed PMID: 11830335.

Herold C, Reck T, Fischler P, Ott R, Radespiel-Troeger M, Ganslmayer M,Hohenberger W, Hahn EG, Schuppan D. Prognosis of a large cohort of patients with
hepatocellular carcinoma in a single European centre. Liver. 2002 Feb;22(1):23-8.PubMed PMID: 11906615.

Schuppan D, Ciccocioppo R. Coeliac disease and secondary autoimmunity. DigLiver Dis. 2002 Jan;34(1):13-5. PubMed PMID: 11926568.

Herold C, Ganslmayer M, Ocker M, Hermann M, Hahn EG, Schuppan D. Combined invitro anti-tumoral action of tamoxifen and retinoic acid derivatives in hepatoma
cells. Int J Oncol. 2002 Jan;20(1):89-96. PubMed PMID: 11743647.

Guenther U, Herbst H, Bauer M, Isbert C, Buhr HJ, Riecken EO, Schuppan D.Collagen type XVIII/endostatin is differentially expressed in primary and
metastatic colorectal cancers and ovarian carcinomas. Br J Cancer. 2001 Nov 16;85(10):1540-5. PubMed PMID: 11720442; PubMed Central PMCID: PMC2363956.

Herold C, Reck T, Ott R, Schneider HT, Becker D, Schuppan D, Hahn EG.Contrast-enhanced ultrasound improves hepatic vessel visualization after
orthotopic liver transplantation. Abdom Imaging. 2001 Nov-Dec;26(6):597-600.PubMed PMID: 11907724.

Warzecha Z, Dembinski A, Konturek PC, Ceranowicz P, Konturek SJ, TomaszewskaR, Schuppan D, Stachura J, Nakamura T. Hepatocyte growth factor attenuates
pancreatic damage in caerulein-induced pancreatitis in rats. Eur J Pharmacol.2001 Oct 26;430(1):113-21. PubMed PMID: 11698071.

Melgert BN, Olinga P, Van Der Laan JM, Weert B, Cho J, Schuppan D, GroothuisGM, Meijer DK, Poelstra K. Targeting dexamethasone to Kupffer cells: effects on
liver inflammation and fibrosis in rats. Hepatology. 2001 Oct;34(4 Pt 1):719-28. PubMed PMID: 11584368.

Rombouts K, Wielant A, Hellemans K, Schuppan D, Geerts A. Influence ofaldosterone on collagen synthesis and proliferation of rat cardiac fibroblasts.
Br J Pharmacol. 2001 Sep;134(1):224-32. PubMed PMID: 11522615; PubMed CentralPMCID: PMC1572936.

Stickel F, Urbaschek R, Schuppan D, Poeschl G, Oesterling C, Conradt C,McCuskey RS, Simanowski UA, Seitz HK. Serum collagen type VI and XIV and
hyaluronic acid as early indicators for altered connective tissue turnover inalcoholic liver disease. Dig Dis Sci. 2001 Sep;46(9):2025-32. PubMed PMID:11575459.

Jia JD, Bauer M, Cho JJ, Ruehl M, Milani S, Boigk G, Riecken EO, Schuppan D.Antifibrotic effect of silymarin in rat secondary biliary fibrosis is mediated by
downregulation of procollagen alpha1(I) and TIMP-1. J Hepatol. 2001Sep;35(3):392-8. PubMed PMID: 11592601.

Jia JD, Bauer M, Sedlaczek N, Herbst H, Ruehl M, Hahn EG, Riecken EO,Schuppan D. Modulation of collagen XVIII/endostatin expression in lobular and
biliary rat liver fibrogenesis. J Hepatol. 2001 Sep;35(3):386-91. PubMed PMID:11592600.

Herold C, Heinz R, Niedobitek G, Schneider T, Hahn EG, Schuppan D.Quantitative testing of liver function in relation to fibrosis in patients with
chronic hepatitis B and C. Liver. 2001 Aug;21(4):260-5. PubMed PMID: 11454189.

Schuppan D, Ruehl M, Somasundaram R, Hahn EG. Matrix as a modulator ofhepatic fibrogenesis. Semin Liver Dis. 2001 Aug;21(3):351-72. Review. PubMedPMID: 11586465.

Bauer M, Schuppan D. TGFbeta1 in liver fibrosis: time to change paradigms?FEBS Lett. 2001 Jul 27;502(1-2):1-3. Review. PubMed PMID: 11478937.

Tannapfel A, Stölzel U, Köstler E, Melz S, Richter M, Keim V, Schuppan D,Wittekind C. C282Y and H63D mutation of the hemochromatosis gene in German
porphyria cutanea tarda patients. Virchows Arch. 2001 Jul;439(1):1-5. PubMedPMID: 11499833.

Shahin M, Konturek JW, Pohle T, Schuppan D, Herbst H, Domschke W. Remodelingof extracellular matrix in gastric ulceration. Microsc Res Tech. 2001 Jun15;53(6):396-408. PubMed PMID: 11525257.

Schuppan D, Hahn EG. IgA anti-tissue transglutaminase: setting the stage forcoeliac disease screening. Eur J Gastroenterol Hepatol. 2001 Jun;13(6):635-7.
Review. PubMed PMID: 11434587.

Badenhoop K, Dieterich W, Segni M, Hofmann S, Hüfner M, Usadel KH, Hahn EG, Schuppan D. HLA DQ2 and/or DQ8 is associated with celiac disease-specific
autoantibodies to tissue transglutaminase in families with thyroid autoimmunity. Am J Gastroenterol. 2001 May;96(5):1648-9. PubMed PMID: 11374722.

Sedlaczek N, Jia JD, Bauer M, Herbst H, Ruehl M, Hahn EG, Schuppan D.Proliferating bile duct epithelial cells are a major source of connective tissue
growth factor in rat biliary fibrosis. Am J Pathol. 2001 Apr;158(4):1239-44.PubMed PMID: 11290541; PubMed Central PMCID: PMC1891909.

Stickel F, Seitz HK, Hahn EG, Schuppan D. [Liver toxicity of drugs of plant origin]. Z Gastroenterol. 2001 Mar;39(3):225-32, 234-7. Review. German. PubMedPMID: 11324140.

Schuppan D, Hahn EG. Clinical studies with silymarin: fibrosis progressionis the end point. Hepatology. 2001 Feb;33(2):483-4. PubMed PMID: 11172360.

Rombouts K, Niki T, Wielant A, Hellemans K, Schuppan D, Kormoss N, Geerts A.Effect of aldosterone on collagen steady state levels in primary and subcultured
rat hepatic stellate cells. J Hepatol. 2001 Feb;34(2):230-8. PubMed PMID:11281551.

Herold C, Heinz R, Radespiel-Tröger M, Schneider HT, Schuppan D, Hahn EG.Quantitative testing of liver function in patients with cirrhosis due to chronic
hepatitis C to assess disease severity. Liver. 2001 Feb;21(1):26-30. PubMed PMID:11169069.

Herold C, Reck T, Ott R, Becker D, Schneider HT, Schuppan D, Hahn EG.Changes in hepatic hemodynamics after orthotopic liver transplantation: color
Doppler sonography. Abdom Imaging. 2001 Jan-Feb;26(1):32-5. PubMed PMID:11116356.

Brzozowski T, Konturek PC, Konturek SJ, Schuppan D, Drozdowicz D, KwiecienS, Majka J, Nakamura T, Hahn E. Effect of local application of growth factors on
gastric ulcer healing and mucosal expression of cyclooxygenase-1 and -2.Digestion. 2001;64(1):15-29. PubMed PMID: 11549833.

Guirouilh J, Le Bail B, Boussarie L, Balabaud C, Bioulac-Sage P, DesmoulièreA, Schuppan D, Rosenbaum J. Expression of hepatocyte growth factor in human
hepatocellular carcinoma. J Hepatol. 2001 Jan;34(1):78-83. PubMed PMID: 11211911.

Schuppan D, Hahn EG. Celiac disease and its link to type 1 diabetes mellitus. J Pediatr Endocrinol Metab. 2001;14 Suppl 1:597-605. Review. PubMed
PMID: 11393550.

Somasundaram R, Ruehl M, Tiling N, Ackermann R, Schmid M, Riecken EO,Schuppan D. Collagens serve as an extracellular store of bioactive interleukin 2.
J Biol Chem. 2000 Dec 8;275(49):38170-5. PubMed PMID: 10982811.

Konturek PC, Karczewska E, Dieterich W, Hahn EG, Schuppan D. Increased prevalence of Helicobacter pylori infection in patients with celiac disease. Am J
Gastroenterol. 2000 Dec;95(12):3682-3. PubMed PMID: 11151941.

Brzozowski T, Konturek PC, Konturek SJ, Pajdo R, Schuppan D, Drozdowicz D,Ptak A, Pawlik M, Nakamura T, Hahn EG. Involvement of cyclooxygenase (COX)-2
products in acceleration of ulcer healing by gastrin and hepatocyte growth factor. J Physiol Pharmacol. 2000 Dec;51(4 Pt 1):751-73. PubMed PMID: 11192947.

Herold C, Berg P, Kupfal D, Becker D, Schuppan D, Hahn EG, Schneider HT.Parameters of microsomal and cytosolic liver function but not of liver perfusion
predict portal vein velocity in noncirrhotic patients with chronic hepatitis C.Dig Dis Sci. 2000 Nov;45(11):2233-7. PubMed PMID: 11215745.

Schuppan D, Hahn EG. Interleukin 10: the magic bullet for liver fibrosis?Gastroenterology. 2000 Nov;119(5):1412-4. PubMed PMID: 11185462.

Rothermund L, Cho JJ, Leggewie S, Schwarz A, Bauer C, Paul M, Neumayer HH,Schuppan D, Hocher B. Activation of the hepatic endothelin-system in rats with
biliary liver fibrosis. J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S270-3.PubMed PMID: 11078396.

Stölzel U, Schuppan D, Tillmann HL, Manns MP, Tannapfel A, Doss MO, Zimmer T, Koszka C, Köstler E. Autoantibodies in porphyria cutanea tarda: a controlled
study. J Hepatol. 2000 Nov;33(5):858-9. PubMed PMID: 11097501.

Schuppan D, Koda M, Bauer M, Hahn EG. Fibrosis of liver, pancreas and intestine: common mechanisms and clear targets? Acta Gastroenterol Belg. 2000
Oct-Dec;63(4):366-70. Review. PubMed PMID: 11233519.

Brinkhaus B, Lindner M, Schuppan D, Hahn EG. Chemical, pharmacological and clinical profile of the East Asian medical plant Centella asiatica.
Phytomedicine. 2000 Oct;7(5):427-48. Review. PubMed PMID: 11081995.

Jia J, Bauer M, Boigk G, Ruehl M, Schuppan D, Wang B. [Expression of collagen XVIII mRNA in rat liver fibrosis]. Zhonghua Gan Zang Bing Za Zhi. 2000
Oct;8(5):274-5. Chinese. PubMed PMID: 11058949.

Stölzel U, Tannapfel A, Wittekind C, Hamm B, Schuppan D. [Indications for liver biopsy in liver tumors]. Dtsch Med Wochenschr. 2000 Sep 8;125(36):1041-4.
Review. German. PubMed PMID: 11022600.

Stallmach A, Chan CC, Ecker KW, Feifel G, Herbst H, Schuppan D, Zeitz M. Comparable expression of matrix metalloproteinases 1 and 2 in pouchitis and
ulcerative colitis. Gut. 2000 Sep;47(3):415-22. PubMed PMID: 10940281; PubMed Central PMCID: PMC1728023.

Schuppan D. Current concepts of celiac disease pathogenesis. Gastroenterology. 2000 Jul;119(1):234-42. Review. PubMed PMID: 10889174.

Schuppan D, Hahn EG. MMPs in the gut: inflammation hits the matrix. Gut. 2000 Jul;47(1):12-4. PubMed PMID: 10861255; PubMed Central PMCID: PMC1727957.

Rothermund L, Leggewie S, Schwarz A, Thöne-Reinecke C, Cho JJ, Bauer C, Paul M, Neumayer HH, Schuppan D, Hocher B. Regulation of the hepatic endothelin system
in advanced biliary fibrosis in rats. Clin Chem Lab Med. 2000 Jun;38(6):507-12.PubMed PMID: 10987198.

Kordonouri O, Dieterich W, Schuppan D, Webert G, Müller C, Sarioglu N,Becker M, Danne T. Autoantibodies to tissue transglutaminase are sensitive
serological parameters for detecting silent coeliac disease in patients with Type 1 diabetes mellitus. Diabet Med. 2000 Jun;17(6):441-4. PubMed PMID: 10975212.

Cho JJ, Hocher B, Herbst H, Jia JD, Ruehl M, Hahn EG, Riecken EO, SchuppanD. An oral endothelin-A receptor antagonist blocks collagen synthesis and
deposition in advanced rat liver fibrosis. Gastroenterology. 2000Jun;118(6):1169-78. PubMed PMID: 10833492.

Dormann H, Krebs S, Muth-Selbach U, Brune K, Schuppan D, Hahn EG, Schneider HT. Rapid onset of hematotoxic effects after interferon alpha in hepatitis C. J
Hepatol. 2000 Jun;32(6):1041-2. PubMed PMID: 10898329.

Beljaars L, Molema G, Schuppan D, Geerts A, De Bleser PJ, Weert B, Meijer DK, Poelstra K. Successful targeting to rat hepatic stellate cells using albumin
modified with cyclic peptides that recognize the collagen type VI receptor. J Biol Chem. 2000 Apr 28;275(17):12743-51. PubMed PMID: 10777570.

Schuppan D. [LIVER FIBROSIS: PATHOGENESIS,PREVENTION AND TREATMENT]. Rev Gastroenterol Peru. 2000 Apr-Jun;20(2):164-168. Spanish. PubMed PMID: 12140600.

Johannsen M, Rühl M, Manski D, Somasundaram R, Riecken EO, Schuppan D. Native extraction of phosphotyrosine-containing proteins: requirement of tyrosine
kinase inhibitors to obtain specific phosphorylation signals. Anal Biochem. 2000  Mar 15;279(2):242-5. PubMed PMID: 10706794.

Ropers T, Kroll W, Becka M, Voelker M, Burchardt ER, Schuppan D, Gehrmann M. Enzyme immunoassay for the measurement of human tenascin-C on the Bayer Immuno 1
analyzer. Clin Biochem. 2000 Feb;33(1):7-13. PubMed PMID: 10693981.

Dieterich W, Storch WB, Schuppan D. Serum antibodies in celiac disease. Clin Lab. 2000;46(7-8):361-4. Review. PubMed PMID: 10934583.

Dieterich W, Riecken EO, Schuppan D. Immunoassay for detection of IgA antitissue transglutaminase in patients with celiac disease. Methods Mol Med.
2000;41:241-5. doi: 10.1385/1-59259-082-9:241. PubMed PMID: 21374443.

1999-1990

vor 1990