Bernd Kaina - Curriculum Vitae
| Bernd Kaina, Dr. rer. nat. habil. |
| Professor of Toxicology and Director |
| Institute of Toxicology |
| University Medical Center |
| Obere Zahlbacher Str. 67 |
| D-55131 Mainz |
| E-mail: kaina@uni-mainz.de |
| Tel. +49 6131 17 9217 |
| Secretary: +49 6131 17 9357 |
Main Research Fields
| DNA repair and genotoxic signaling |
| Mechanisms of chemical carcinogenesis |
| Mechanisms of anticancer drugs and DNA damage-triggered apoptosis |
Scientific Career
| 1968-1975 | Study of Biology, University Halle |
| 1977 | Ph.D. in Genetics, University Halle |
| 1976-1984 | Postdoctoral fellow and scientific coworker at the Central Institute of Genetics and Cultural Plant Breeding, Academy of Sciences of DDR, Gatersleben (East-Germany) |
| 1984-1985 | Grant holder of the C.E.C. (Communities of European Countries) at the Laboratory of Molecular Genetics, State University of Leiden (The Netherlands) |
| 1985-1987 | Guest researcher at the German Cancer Research Center, Department of Biochemistry, Heidelberg |
| 1987-1993 | Group leader at the Institute of Genetics and Toxicology, Kernforschungszentrum Karlsruhe and University of Karlsruhe |
| 1990 | Habilitation, University Karlsruhe |
| 1992 | Venia legendi for Genetics and Toxicology, University Karlsruhe |
| 1993 | Professor of Toxicology (C3) and Head of the Division of Applied Toxicology at the Institute of Toxicology, Johannes Gutenberg University Mainz |
| 2003 | Appointed Professor of Toxicology (C4) and Chair of General and Medical Toxicology at the Medical Center, University Göttingen, rejected |
| 2004 | Professor of Toxicology (C4) and Head of the Institute of Toxicology, University Medical Center, Mainz |
Scholarships, Awards and Honors
| 1987-1992 | Heisenberg research grant (Heisenberg-Stipendium) of the Deutsche Forschungsgemeinschaft |
| 2000 | Evaluation by “Laborjournal” (Volume 02/2000): First rank among the toxicologists in Germany/Austria/Switzerland |
| 2007 | Evaluation by “Laborjournal” (Volume 09/2007): First rank among the toxicologists in Germany/Austria/Switzerland |
| 2010 | Award of the German Society of Environmental Mutagenesis (GUM) |
| 2011 | Cancer Award of the German Cancer Society |
| 2012 | Toxicology Award of the German Society of Toxicology |
| 2014 | Ulrich Hagen-Preis der Deutschen Gesellschaft für Strahlenbiologie (GBS) |
Service to the Community
| 1998-2002 | Founding member and first president of the German Society of DNA Repair (DGDR); till today member of the board of the society |
| Since 1990 | Reviewer for scientific journals |
| Since 1993 | Reviewer for various scientific foundations, e.g. German Research Council (DFG), German Cancer Research Foundation, German-Israelian Foundation, Sander Foundation and others |
| Since 2004 | Editorial board member of DNA Repair, Mutation Research, Anticancer Research, International Journal of Oncology, Current Cancer Therapy Reviews |
| 2004-2010 | Chairman of the DFG Research Unit FOR 527 “Susceptibility Factors of Tumorigenesis“ |
| Since 2008 | “Vertrauensdozent“ of the Deutsche Forschungsgemeinschaft (DFG) of the University Mainz |
Publications
| Web of Science search: Citations: 11,261; Average citations per item: 25.69; h-index: 58 |
| PubMed accessible papers: 254 |
Selected Recent Publications
| Roos, W.P., S. Quiros, A. Krumm, S. Mertz, O. Switzeny, M. Christmann, C. Loquai and B. Kaina (2014) B-Raf Inhibitor vemurafenib in combination with temozolomide and fotemustine in the killing response of malignant melanoma cells, Oncotarget, 5, 12607-12620 |
| Knizhnik, A.V., W.P. Roos, T. Nikolova, S. Quiros, K.H. Tomaszowski, M. Christmann and B. Kaina (2013) Survival and death strategies in glioma cells: autophagy, senescence and apoptosis triggered by a single type of temozolomide-induced DNA damage, PLoS ONE, 2013; 8(1):e55665 |
| Bauer, M., M. Goldstein, D. Heylmann and B. Kaina (2012) Human monocytes undergo excessive apoptosis following temozolomide activating the ATM/ATR pathway while dendritic cells and macrophages are resistant, PLoS ONE, 7(6): e39956 |
| Bauer, M., M. Goldstein, M. Christmann, H. Becker, D. Heylmann and B. Kaina (2011) Human monocytes are severely impaired in base and DNA double-strand break repair that renders them vulnerable to oxidative stress, Proc. Natl. Acad. Sci. USA, 108, 21105-21110. |
| Roos, W.P., E. Jöst, C. Belohlavek, G. Nagel, G. Fritz and B. Kaina (2011) Intrinsic anticancer drug resistance of malignant melanoma cells is abrogated by interferon-ß and valproic acid, Cancer Res., 15, 4150-4160 |
| Batista LFZ., W.P. Roos, M. Christmann, CFM. Menck and B. Kaina (2007) Differential sensitivity of malignant glioma cells to methylating and chloroethylating anticancer drugs: p53 determines the switch by regulating xpc, ddb2 and DNA double-strand breaks, Cancer Res., 67, 11886-11895 |
| Briegert M. and B. Kaina (2007) Human monocytes, but not dendritic cells derived from them, are defective in base excision repair and hypersensitive to methylating agents, Cancer Res., 67, 26-31 |
| Roos W.P., M. Christmann, ST. Fraser and B. Kaina (2007) Mouse embryonic stem cells are hypersensitive to apoptosis triggered by the DNA damage O6-methylguanine due to high E2F1 regulated mismatch repair, Cell Death Diff., 14, 1422-1432 |