Current Research:

Haematological disorders have a high frequency amongst the general population, especially in view of clonal hematopoiesis, which increases with increasing age. Clonal haematopoiesis of indeterminate potential (CHIP) and haematological cancers pose a serious health care problem. Current therapies of the haematological malignancies are frequently not curative due to lack of eradication of leukemic stem cells (LSC), and survival, depending on the cancer and age group, is low. The bone marrow plays a central role in many medical disciplines, as it generates all cellular constituents of our blood and acts as the site of attack for chemotherapy, personalised medicine drugs and cellular therapies. However, exploitation of the bone marrow microenvironment (BMM) as a direct target of innovative therapies is in its infancy, although this holds great promise.