German Cancer Consortium (DKTK)

The German Cancer Consortium (DKTK) was founded in 2012 to support the aim of implementing promising new cancer research findings into the clinic as quickly as possible. Therefore, seven partner locations with their research institutes and university hospitals cooperate with the German Cancer Research Center (DKFZ). The DKTK as a long-term, joint initiative involves not only the DKFZ, but also the German Federal Ministry of Education and Research (BMBF) and the participating German states.

DKTK partner-site Frankfurt/Mainz

At the DKTK partner-site Frankfurt/Mainz, the University of Frankfurt and the University Medical Center Mainz collaborate with their complementary expertise in translational cancer research. Frankfurt significantly contributes to molecularly targeted therapies. Mainz stands above all for nationally and internationally outstanding immunotherapeutic approaches, which are promoted at the UCT Mainz in close cooperation with the biotech industry and with non-university institutions. Here, TRON and the PKZI play a special role. Besides, in collaboration with the University Medical Center and the Johannes Gutenberg-University Mainz, the UCT Mainz brings further expertise, especially in the field of DNA repair research, epigenetics, and resistance development in tumor diseases, in the molecular diagnostics in early detection of cancer, and in tumor epidemiology and outcome research.

The scientists and clinicians of the DKTK partner-site Frankfurt/Mainz aim for the discovery of new cancer mechanisms (exploitation of oncogenic mechanisms), find ways to identify the importance of these mechanisms in individual patients (molecular diagnostics) to therapeutically interfere with them (drug discovery and development, molecular therapy, immunotherapy, radiation therapy), and perform clinical trials to validate these novel diagnostics and therapeutics.

DKTK Spokesperson Mainz

Prof. Dr. med. Matthias Theobald

Prof. Dr. med. Matthias Theobald

Director of the Department of Internal Medicine III, Hematology & Medical Oncology

DKTK Projects Mainz

The focus of Mainz for the DKTK is based on contributions to the tumor immunology / therapy program. In addition, Mainz participated and participates in different projects in the DKTK Joint Funding Program.

  • DKTK Molecularly Aided Stratification for Tumor ERadication (DKTK MASTER)
  • Impact of mutational pathways on immune environment, neoantigens and tumor rejection for the development of comprehensive biomarker panels and combinatorial approaches in cancer immunotherapy (ImmuNEO MASTER) 
  • Chimeric antigen receptor-engineered natural killer cells as a universal cellular therapeutic for adoptive cancer immunotherapy (UniCAR NK cells)
  • SI Individualized surgical oncology of gastrointestinal tumors (SI Surgery)
  • SI Joint Imaging Platform (SI JIP)
  • Molecular Tumor Board Alliance (MTBA)
  • Clinical development of lead NEOantigen-specific T cell receptor for Adoptive T cell therapy of solid tumors (NEO-ATT) 
  • Anatomical Resection of liver MetAstases iN patIents with RAS-mutated colorectal cancer (ARMANI): A randomized, multicenter, controlled trial 
  • Characterization of the osteo-hematopoietic niche during malignant evolution (CHOICE)
  • Treatment of prostate carcinoma and squamous cell carcinoma of the lung with a novel bispecific PSMAxCD3 antibody 
  • Cross-institutional, prospective, open label, single group, molecularly stratified phase I study of combined CRAF and MEK inhibition in advanced-stage malignancies harboring BRAF mutations with impaired kinase activity (SORATRAM)
  • INFORM/MASTER-PRO
  • Individualized Therapy for Relapsed Malignancies in Childhood (INFORM)
  • Anti-tumor immune responses induced by CAR-NK cell therapy in combination with checkpoint blockade in patients with glioblastoma (CAR2-BRAIN) 
  • Multidimensional Analysis of Response and Resistance to PARP Inhibition in Advanced-Stage MaliGnanciEs (MARRIAGE) 
  • Exploiting liquid biopsies to advance cancer precision medicine (EXLIQUID) 
  • Monitoring the immune modulating effects of combinatorial targeted and immune checkpoint inhibitor treatment (MIMETIC)
  • TME Modulation & Enhanced Antitumor Immunity (ASTRON)

School of Oncology

The School of Oncology is designed for the training of scientists and clinicians in translational oncology. In addition to a cross-disciplinary training program within the partner site Frankfurt/Mainz and the DKTK in general, junior researchers will be integrated into an active scientific community. Annual retreats and summer schools, further training seminars and workshops as well as lecture series and exchange programs, which all focus on translational oncology, are available for the School of Oncology fellows to keep up a continuous insight into translational cancer research and clinical oncology.  

Interested in becoming a School of Oncology fellow?

If you are a clinician and haven't finished your residency yet, or if you are a scientist with medical background (up to 6 years after obtaining your doctorate), you can apply all year round by getting into contact with the School of Oncology coordinator in Mainz.

School of Oncology Fellows

Since 2016, a total of 10 fellows from the UCT Mainz have participated in the DKTK School of Oncology program, contributing to and benefiting from this nationwide network for young researchers in translational cancer medicine. Currently, there are 4 fellows still active in the program.

 Stefanie Deckert

Stefanie Deckert

Institute of Pathology - Research Group Tagscherer/Roth

DKTK Program: Exploitation of Oncogenic Mechanisms

Dr. rer. nat Nadezda Dolgikh

Dr. rer. nat Nadezda Dolgikh

Department of Internal Medicine III - Hematology & Medical Oncology - Research Group Kühn

DKTK Program: Molecularly Targeted Therapy

Dr. med. Korbinian Nepomuk Kropp

Dr. med. Korbinian Nepomuk Kropp

Department of Internal Medicine III - Hematology & Medical Oncology - Research Group Wölfel

DKTK Program: Cancer Immunotherapy

Dr. med. Johanna Rausch

Dr. med. Johanna Rausch

Department of Internal Medicine III - Hematology & Medical Oncology - Research Group Kühn

DKTK Program: Cancer Immunotherapy

DKTK Rhein-Main Cancer Retreat

The annual DKTK Rhein-Main Cancer Retreat, jointly organized by the UCT Frankfurt and UCT Mainz, offers a platform for scientific exchange and collaboration within the DKTK partner sites. The event provides an update on current research projects from various groups and the ongoing work of the DKTK School of Oncology fellows, who will present their research in dedicated sessions.