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Institute of Medical Biostatistics,
Epidemiology and Informatics (IMBEI)

Visual Universitätsmedizin Mainz

Prof. Dr. rer. nat. Konstantin Strauch

Strauch_KS.jpg

Bulding: Bonifazius-Turm A
21. floor, room 05
Phone: +49 (0)6131 17-7369 or +49 (0) 6131 39-38700
Mail:  strauch@uni-mainz.de 

 

 

Function

Director of Institute

Research interests

  • Development and application of biostatistical and bioinformatics methods in clinical and genetic epidemiology
  • Analysis of common and rare genetic variants and polygenic risk scores with various phenotypes
  • Development and implementation of specialized analytical approaches for family studies, such as estimation of disease model parameters, modeling gene-gene and gene-environment interactions, and epigenetic effects
  • Prediction and early diagnosis of diseases using molecular markers and high-dimensional statistical learning techniques as a basis of an individualized prevention or therapy
  • Design and analysis of clinical trials (diagnostic, prognostic, therapeutic) ranging from phase I to IV
  • Data handling, privacy and ethical aspects of genomic and other molecular markers in population-based and clinical cohort studies
  • Integration of routine clinical data of patients to be used for biomedical research projects

Short CV

Professional career

  • Since 10/2019 Professor (W3) of Medical Biostatistics and Epidemiology and Director of Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center of the Johannes Gutenberg University Mainz
  • 2011-2019 Professor (W3) of Genetic Epidemiology, Medical Faculty, Ludwig-Maximilians-University Munich and Director of Institute of Genetic Epidemiology at Helmholtz Zentrum München
  • 2005-2010 Professor (W2) of Medical Biometry and Epidemiology and Head of Center for Methods in Genetic Epidemiology (GEM), Institute of Medical Biometry and Epidemiology, Medical Faculty, Philipps University Marburg
  • 1997-2005 Research fellow, Institute for Medical Biometry, Informatics and Epidemiology, Medical Faculty, University of Bonn

Academic training

  • 2010 Certificate "Biometrics in Medicine" by the German Society of Medical Informatics, Biometry and Epidemiology (GMDS) and the German Region of the International Biometric Society (IBS-DR)
  • 2000-2005 Habilitation in Genetic Epidemiology at the Medical Faculty of the University of Bonn
  • 1996-2000 Ph.D. in Statistical Genetics / Theoretical Biology (Dr. rer. nat.) at the University of Bonn
  • 1991-1996 Physics studies (M.A. / Diplom) at the University of Würzburg and the State University of New York at Stony Brook, USA

Activities and honors

  • Since 2021 Member of the Ethics Committee of the State Medical Association of Rhineland-Palatinate
  • Since 2020 Member of the Corona expert panel of the State of Rhineland-Palatinate
  • Since 2019 Member of the Steering Board of the Gutenberg Health Study (GHS) as well as of the Steering Committee of the University Center for Tumor Diseases (UCT) at University Medical Center of the Johannes Gutenberg University Mainz
  • 2017-2018 Elected to the Board of the German Society of Medical Informatics, Biometry and Epidemiology (GMDS)
  • Since 2012 Gendiagnostik-Kommission (German Gene Diagnostics Commission) at the Robert Koch Institute (deputy member)
  • 2012-2019 Member of the Examination Board for the study programs Master of Public Health (MPH) and Master of Science (MSc) Epidemiology, Medical Faculty, Ludwig-Maximilians-University Munich
  • 2011-2019 Member of the KORA Study Board (Cooperative Health Research in the Region of Augsburg) at Helmholtz Zentrum München
  • 2007-2009 Elected to the Board of Directors of the International Genetic Epidemiology Society (IGES)
  • 2006-2011 Editorial Board of the Journal Genetic Epidemiology
  • 2006-2010 Ethics Committee of the Medical Faculty, Philipps University Marburg (2006-2009 deputy member; 2010 member)
  • 2003 Johann Peter Süßmilch Medal by the German Society of Medical Informatics, Biometry and Epidemiology (GMDS)
  • 1992-1996 Scholarship by the Studienstiftung des deutschen Volkes (German National Academic Foundation); Special scholarship 1994-1995 for studies at the State University of New York at Stony Brook, USA
  • 1991 Dietrich Bonhoeffer Award by the Christophorus School in Braunschweig (Germany)

Other professional activities 

Memberships:

  • Since 2021 Medical Society Mainz
  • Since 2011 German Region of the International Biometric Society (IBS-DR)
  • Since 2004 Deutscher Hochschulverband (German Association of University Professors and Lecturers)
  • Since 2002 German Society of Medical Informatics, Biometry and Epidemiology (GMDS); elected to the Board 2017-2018
  • Since 2001 International Genetic Epidemiology Society (IGES); Education Committee 2002-2007; elected to the Board of Directors 2007-2009

Links to presentations

Publications

PubMed

Selected publications

  • Ha CSR, Müller-Nurasyid M, Petrera A, Hauck SM, Marini F, Bartsch DK, Slater EP, Strauch K (2023) Proteomics biomarker discovery for individualized prevention of familial pancreatic cancer using statistical learning. PLoS One 18(1):e0280399.
  • Orth MF, Surdez D, Faehling T, Ehlers AC, Marchetto A, Grossetête S, Volckmann R, Zwijnenburg DA, Gerke JS, Zaidi S, Alonso J, Sastre A, Baulande S, Sill M, Cidre-Aranaz F, Ohmura S, Kirchner T, Hauck SM, Reischl E, Gymrek M, Pfister SM, Strauch K, Koster J, Delattre O, Grünewald TGP (2022) Systematic multi-omics cell line profiling uncovers principles of Ewing sarcoma fusion oncogene-mediated gene regulation. Cell Reports 41(10):111761.
  • Ludt A, Ustjanzew A, Binder H, Strauch K, Marini F (2022) Interactive and reproducible workflows for exploring and modeling RNA-seq data with pcaExplorer, ideal, and GeneTonic. Current Protocols 2(4):e411.
  • Portilla-Fernandez E, Klarin D, Hwang SJ, Biggs ML, Bis JC, Weiss S, Rospleszcz S, … Strauch K, Meitinger T, O'Donnell CJ, Dehghan A; VA Million Veteran Program (2022) Genetic and clinical determinants of abdominal aortic diameter: genome-wide association studies, exome array data and Mendelian randomization study. Human Molecular Genetics 31(20):3566-3579.
  • Schepers M, Zanger P, Jahn K, König J, Strauch K, Gianicolo E (2022) Multi-household social gatherings contribute to the second SARS-CoV-2 wave in Rhineland-Palatinate, Germany, August to November 2020. Journal of Infection 84(4):551-557.
  • Marini F, Ludt A, Linke J, Strauch K (2021) GeneTonic: an R/Bioconductor package for streamlining the interpretation of RNA-seq data. BMC Bioinformatics 22(1):610.
  • Landmann E, Brugger M, Blank V, Wudy SA, Hartmann M, Strauch K, Rudloff S (2021) Adrenal steroid metabolism and blood pressure in 5- to 7-year-old children born preterm as compared to peers born at term. Frontiers in Pediatrics 9:754989.
  • Aboulmaouahib B, Kastenmüller G, Suhre K, Zöllner S, Weissensteiner H, Gieger C, Wang-Sattler R, Lichtner P, Strauch K, Flaquer A (2021) First mitochondrial genome wide association study with metabolomics. Human Molecular Genetics Oct 27:ddab312. doi: 10.1093/hmg/ddab312. Epub ahead of print.
  • Slater EP, Wilke LM, Böhm LB, Strauch K, Lutz M, Gercke N, Matthäi E, Hemminki K, Försti A, Schlesner M, Paramasivam N, Bartsch DK (2021) Combinations of low-frequency genetic variants might predispose to familial pancreatic cancer. Journal of Personalized Medicine 11(7):631.
  • Ruth KS, Day FR, Hussain J, Martínez-Marchal A, Aiken CE, Azad A, … Strauch K, … Murabito JM, Ong KK, Hoffmann ER, Murray A, Roig I, Perry JRB (2021) Genetic insights into biological mechanisms governing human ovarian ageing. Nature 596(7872):393-397.
  • McCartney DL, Min JL, Richmond RC, Lu AT, Sobczyk MK, Davies G, … Strauch K, … Deary IJ, Relton CL, Horvath S, Marioni RE (2021) Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging. Genome Biology 22:194.
  • Pol-Fuster J, Cañellas F, Ruiz-Guerra L, Medina-Dols A, Bisbal-Carrió B, Asensio V, Ortega-Vila B, Marzese D, Vidal C, Santos C, Lladó J, Olmos G, Heine-Suñer D, Strauch K, Flaquer A, Vives-Bauzà C (2021) Familial psychosis associated with a missense mutation at MACF1 gene combined with the rare duplications DUP3p26.3 and DUP16q23.3, affecting the CNTN6 and CDH13 genes. Frontiers in Genetics 12:622886
  • Burchert A, Bug G, Fritz LV, Finke J, Stelljes M, Röllig C, Wollmer E, Wäsch R, Bornhäuser M, Berg T, Lang F, Ehninger G, Serve H, Zeiser R, Wagner E-M, Kroeger N, Wolschke C, Schleuning M, Götze KS, Schmid C, Crysandt M, Eßeling E, Wolf D, Wang Y, Böhm A, Thiede C, Haferlach T, Michel C, Bethge W, Wündisch T, Brandts C, Harnisch S, Wittenberg M, Hoeffkes H-G, Rospleszcz S, Burchardt A, Neubauer A, Brugger M, Strauch K, Schade-Brittinger C, Metzelder SK (2020) Sorafenib maintenance after allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia with FLT3-internal tandem duplication mutation (SORMAIN). Journal of Clinical Oncology 38(26):2993-3002.
  • Gianicolo EAL, Eichler M, Muensterer O, Strauch K, Blettner M (2020) Methods for evaluating causality in observational studies. Deutsches Ärzteblatt International 116(7):101-107.
  • Brugger M, Knapp M, Strauch K (2019) Properties and evaluation of the MOBIT – a novel linkage-based test statistic and quantification method for imprinting. Statistical Applications in Genetics and Molecular Biology 18(4):20180025.
  • Wuttke M, Li Y, Li M, Sieber KB, Feitosa MF, Gorski M, … Strauch K, … Edwards TL, Snieder H, Stefansson K, Hung AM, Heid IM, Scholz M, Teumer A, Köttgen A, Pattaro C (2019) A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nature Genetics 51(6):957-972.
  • Flannick J, Mercader JM, Fuchsberger C, Udler MS, Mahajan A, Wessel J, Teslovich TM, Caulkins L, Koesterer R, … Strauch K, … Altshuler D, Burtt NP, Scott LJ, Morris AP, Florez JC, McCarthy MI, Boehnke M (2019) Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. Nature 570(7759):71-76.
  • Bartsch DK, Gercke N, Strauch K, Wieboldt R, Matthäi E, Wagner V, Rospleszcz S, Schäfer A, Franke FS, Mintziras I, Bauer C, Grote T, Figiel J, Di Fazio P, Burchert A, Reinartz S, Pogge von Strandmann E, Klöppel G, Slater EP (2018) The combination of miRNA-196b, LCN2, and TIMP1 is a potential set of circulating biomarkers for screening individuals at risk for familial pancreatic cancer. Journal of Clinical Medicine 7(10):295.
  • Cheney CP, Thorand B, Huth C, Berger K, Peters A, Seifert-Klauss V, Kiechle M, Strauch K, Quante AS (2018) The association between serum 25-hydroxyvitamin D and cancer risk: results from the prospective KORA F4 study. Oncology Research and Treatment 41(3):117-121.
  • Brugger M, Rospleszcz S, Strauch K (2017) Estimation of trait-model parameters in a MOD score linkage analysis. Human Heredity 82(3-4):103-139.
  • Ferreira MA, Vonk JM, Baurecht H, Marenholz I, Tian C, Hoffman JD, … Strauch K, … Lee YA, Boomsma DI, Almqvist C, Karlsson R, Koppelman GH, Paternoster L (2017) Shared genetic origin of asthma, hay fever and eczema elucidates allergic disease biology. Nature Genetics 49(12):1752-1757.
  • Ried JS, Jeff M J, Chu AY, Bragg-Gresham JL, van Dongen J, Huffman JE, … Strauch K, … Strachan DP, Frayling T, Hirschhorn JN, Müller-Nurasyid M, Loos RJ (2016) A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. Nature Communications 7:13357.
  • Barban N, Jansen R, de Vlaming R, Vaez A, Mandemakers JJ, Tropf FC, … Strauch K, … Cesarini D, Koellinger PD, den Hoed M, Snieder H, Mills MC (2016) Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nature Genetics 48(12):1462-1472.
  • Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, Ma C, … Strauch K, … Burtt NP, Mohlke KL, Meitinger T, Groop L, Abecasis G, Florez JC, Scott LJ, Morris AP, Kang HM, Boehnke M, Altshuler D, McCarthy MI (2016) The genetic architecture of type 2 diabetes. Nature 536(7614):41-47.
  • Quante A, Ming C, Rottmann M, Engel J, Boeck S, Heinemann V, Westphalen CB, Strauch K (2016) Projections of cancer incidence and cancer-related deaths in Germany by 2020 and 2030. Cancer Medicine 5(9):2649-2656.
  • Baurecht H, Hotze M, Rodriguez E, Manz J, Weidinger S, Cordell HJ, Augustin T, Strauch K (2016) Compare and Contrast Meta Analysis (CCMA): A method for identification of pleiotropic loci in genome-wide association studies. PLoS One 11(5):e0154872.
  • Teymoortash A, Pfestroff A, Wittig A, Franke N, Hoch S, Harnisch S, Schade-Brittinger C, Hoeffken H, Engenhart-Cabillic R, Brugger M, Strauch K (2016) Safety and efficacy of botulinum toxin to preserve gland function after radiotherapy in patients with head and neck cancer: a prospective, randomized, placebo-controlled, double-blinded phase I clinical trial. PLoS One 11(3):e0151316.
  • Stitziel NO, Stirrups KE, Masca NGD, Erdmann J, Ferrario PG, König IR, … Strauch K, … Watkins H, Willer CJ, Kathiresan S, Deloukas P, Samani NJ, Schunkert H (2016) Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease. New England Journal of Medicine 374(12):1134-1144.
  • Quante AS, Herz J, Whittemore AS, Fischer C, Strauch K, Terry MB (2015) Assessing absolute changes in breast cancer risk due to modifiable risk factors. Breast Cancer Research and Treatment 152(1):193-197.
  • Quante AS, Whittemore AS, Shriver T, Hopper JL, Strauch K, Terry MB (2015) Practical problems with clinical guidelines for breast cancer prevention based on remaining lifetime risk. Journal of the National Cancer Institute 107(7):djv124.
  • Viniol A, Jegan N, Brugger M, Leonhardt C, Barth J, Baum E, Becker A, Strauch K (2015) Even worse – Risk factors and protective factors for transition from chronic localized low back pain to chronic widespread pain in general practice: a cohort study. Spine 40(15):E890-E899.
  • Flaquer A, Rospleszcz S, Reischl E, Zeilinger S, Prokisch H, Meitinger T, Meisinger C, Peters A, Waldenberger M, Grallert H, Strauch K (2015) Mitochondrial GWA analysis of lipid profile identifies genetic variants to be associated with HDL cholesterol and triglyceride levels. PLoS One 10(5):e0126294.
  • Flaquer A, Baumbach C, Ladwig KH, Kriebel J, Waldenberger M, Grallert H, Baumert J, Meitinger T, Kruse J, Peters A, Emeny R, Strauch K (2015) Mitochondrial genetic variants identified to be associated with posttraumatic stress disorder. Translational Psychiatry 5:e524.
  • Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, … Strauch K, … Heid IM, Loos RJ, Cupples LA, Morris AP, Lindgren CM, Mohlke KL (2015) New genetic loci link adipose and insulin biology to body fat distribution. Nature 518(7538):187-196.
  • Brugger M, Strauch K (2014) Fast linkage analysis with MOD scores using algebraic calculation. Human Heredity 78(3-4):179-194.
  • Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, … Strauch K, … Abecasis GR, Chasman DI, Goddard ME, Visscher PM, Hirschhorn JN, Frayling TM (2014) Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics 46(11):1173-1186.
  • Flaquer A, Baumbach C, Kriebel J, Meitinger T, Peters A, Waldenberger M, Grallert H, Strauch K (2014) Mitochondrial genetic variants identified to be associated with BMI in adults. PLoS One 9(8):e105116.
  • Slater EP, Strauch K, Rospleszcz S, Ramaswamy A, Esposito I, Klöppel G, Matthäi E, Heeger K, Fendrich V, Langer P, Bartsch DK (2014) MicroRNA-196a and -196b as potential biomarkers for the early detection of familial pancreatic cancer. Translational Oncology 7(4):464-471.
  • Hirsch O, Strauch K, Held H, Redaelli M, Chenot JF, Leonhardt C, Keller S, Baum E, Pfingsten M, Hildebrandt J, Basler HD, Kochen MM, Donner-Banzhoff N, Becker A (2014) Low back pain patient subgroups in primary care: pain characteristics, psychosocial determinants, and health care utilization. Clinical Journal of Pain 30(12):1023-1032.
  • Flaquer A, Heinzmann A, Rospleszcz S, Mailaparambil B, Dietrich H, Strauch K, Grychtol R (2014) Association study of mitochondrial genetic polymorphisms in asthmatic children. Mitochondrion 14(1):49-53.
  • Flaquer A, Baumbach C, Piñero E, García Algas F, de la Fuente Sanchez MA, Rosell J, Toquero J, Alonso-Pulpon L, Garcia-Pavia P, Strauch K, Heine-Suñer D (2013) Genome-wide linkage analysis of congenital heart defects using MOD score analysis identifies two novel loci. BMC Genetics 14:44.
  • Zeilinger S, Kühnel B, Klopp N, Baurecht H, Kleinschmidt A, Gieger C, Weidinger S, Lattka E, Adamski J, Peters A, Strauch K, Waldenberger M, Illig T (2013) Tobacco smoking leads to extensive genome-wide changes in DNA methylation. PLoS One:8(5):e63812.
  • Slater EP, Fendrich V, Strauch K, Rospleszcz S, Ramaswamy A, Mätthai E, Chaloupka B, Gress TM, Langer P, Bartsch DK (2013) LCN2 and TIMP1 as potential serum markers for the early detection of familial pancreatic cancer. Translational Oncology 6(2):99-103.
  • Quante AS, Whittemore AS, Shriver T, Strauch K, Terry MB (2012) Breast cancer risk assessment across the risk continuum: genetic and nongenetic risk factors contributing to differential model performance. Breast Cancer Research 14(6):R144.
  • Künzel T, Strauch K (2012) Parameter estimation and quantitative parametric linkage analysis with GENEHUNTER-QMOD. Human Heredity 73(4):208-219.
  • Becker A, Held H, Redaelli M, Chenot JF, Leonhardt C, Keller S, Baum E, Pfingsten M, Hildebrandt J, Basler HD, Kochen MM, Donner-Banzhoff N, Strauch K (2012) Implementation of a guideline for low back pain management in primary care: a cost-effectiveness analysis. Spine 37(8):701-710.
  • Heinzmann A, Brugger M, Bierbaum S, Mailaparambil B, Kopp MV, Strauch K (2010) Joint influence of Acidic-Mammalian-Chitinase with Interleukin-4 and Toll-like Receptor-10 with Interleukin-13 in the genetics of asthma. Pediatric Allergy and Immunology 21(4 Pt 2):e679-e686.
  • Slater EP, Langer P, Niemczyk E, Strauch K, Butler J, Habbe N, Neoptolemos JP, Greenhalf W, Bartsch DK (2010) PALB2 mutations in European familial pancreatic cancer families. Clinical Genetics 78(5):490-494.
  • Flaquer A, Abou Jamra R, Etterer K, Orozco Diaz G, Rivas F, Rietschel M, Cichon S, Nöthen MM, Strauch K (2010) A new susceptibility locus for bipolar affective disorder in PAR1 on Xp22.3/Yp11.3. American Journal of Medical Genetics Part B 153B(5):1110-1114.
  • Fritz P, Kraus H-J, Mühlnickel W, Sassmann V, Hering W, Strauch K (2010) High-frequency jet ventilation for complete target immobilization and reduction of the planning target volume in stereotactic high single-dose irradiation of stage I non-small cell lung cancer and lung metastases. International Journal of Radiation Oncology, Biology, Physics 78(1):136-142.
  • Wermter A, Kamp-Becker I, Hesse P, Schulte-Körne G, Strauch K, Remschmidt H (2010) Evidence for the involvement of genetic variation in the Oxytocin Receptor Gene (OXTR) in the etiology of autistic disorders on high-functioning level. American Journal of Medical Genetics Part B 153B(2):629-639.
  • Shaaban S, Matsuo T, Strauch K, Ohtsuki H (2009) Investigation of parent-of-origin effect in comitant strabismus using MOD score analysis. Molecular Vision 15:1351-1358.
  • Rissling I, Strauch K, Höft C, Oertel WH, Möller JC (2009) Haplotype analysis of the engrailed-2 gene in young-onset Parkinson’s disease. Neurodegenerative Diseases 6(3):102-105.
  • Heinzmann A, Brugger M, Engels C, Prömpeler H, Superti-Furga A, Strauch K, Krueger M (2009) Risk factors of neonatal respiratory distress following vaginal delivery and Caesarean section in the German population. Acta Paediatrica 98(1):25-30.
  • Mattheisen M, Dietter J, Knapp M, Baur MP, Strauch K (2008) Inferential testing for linkage with GENEHUNTER-MODSCORE: the impact of the pedigree structure on the null distribution of multipoint MOD scores. Genetic Epidemiology 32(1):73-83.
  • Strauch K (2007) MOD-score analysis with simple pedigrees: an overview of likelihood-based linkage methods. Human Heredity 64(3):192-202.
  • Dietter J, Mattheisen M, Fürst R, Rüschendorf F, Wienker TF, Strauch K (2007) Linkage analysis using sex-specific recombination fractions with GENEHUNTER-MODSCORE. Bioinformatics 23(1):64-70.
  • Pinto D, Kasteleijn-Nolst Trenité DGA, Cordell HJ, Mattheisen M, Strauch K, Lindhout D, Koeleman BPC (2007) Explorative two-locus linkage analysis suggests a multiplicative interaction between the 7q32 and 16p13 myoclonic seizures-related photosensitivity loci. Genetic Epidemiology 31(1):42-50.
  • Berger M, Mattheisen M, Kulle B, Schmidt H, Oldenburg J, Bickeböller H, Walter U, Lindner T, Strauch K, Schambeck CM (2005) High factor VIII levels in venous thromboembolism show linkage to imprinted loci on chromosomes 5 and 11. Blood 105(2):638-644.
  • Strauch K, Baur MP, Wienker TF (2004) A recoding scheme for X-linked and pseudoautosomal loci to be used with computer programs for autosomal LOD-score analysis. Human Heredity 58(1):55-58
  • Dietter J, Spiegel A, an Mey D, Pflug HJ, Al-Kateb H, Hoffmann K, Wienker TF, Strauch K (2004) Efficient two-trait-locus linkage analysis through program optimization and parallelization: application to hypercholesterolemia. European Journal of Human Genetics 12(7):542-550.
  • Kurz T, Strauch K, Dietrich H, Braun S, Hierl S, Jerkic SP, Wienker TF, Deichmann KA, Heinzmann A (2004) Multilocus haplotype analyses reveal association between 5 novel IL-15 polymorphisms and asthma. Journal of Allergy and Clinical Immunology 113(5):896-901
  • Knapp M, Strauch K (2004) Affected-sib-pair test for linkage based on constraints for identical-by-descent distributions corresponding to disease models with imprinting. Genetic Epidemiology 26(4):273-285.
  • Strauch K, Fimmers R, Baur MP, Wienker TF (2003) How to model a complex trait. 2. Analysis with two disease loci. Human Heredity 56(4):200-211.
  • Strauch K, Fimmers R, Baur MP, Wienker TF (2003) How to model a complex trait. 1. General considerations and suggestions. Human Heredity 55(4):202-210.
  • Kurz T, Strauch K, Heinzmann A, Braun S, Jung M, Rüschendorf F, Moffatt MF, Cookson WO, Inacio F, Ruffilli A, Nordskov-Hansen G, Peltre G, Forster J, Kuehr J, Reis A, Wienker TF, Deichmann KA (2000) A European study on the genetics of mite sensitization. Journal of Allergy and Clinical Immunology 106(5):925-932.
  • Strauch K, Fimmers R, Kurz T, Deichmann KA, Wienker TF, Baur MP (2000) Parametric and nonparametric multipoint linkage analysis with imprinting and two-locus-trait models: application to mite sensitization. American Journal of Human Genetics 66(6):1945-1957.