Outcome Research

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The UCT Mainz has a long-standing expertise in cancer epidemiology and outcome research with a specific focus on the identification of risk factors for cancer incidence and mortality and on late effects after cancer treatment. Research on late effects comprises analyses of survival, occurrence of secondary malignancies and cardiovascular late effects, quality of life, psychosocial rehabilitation, and cancer survivorship.
 

Aims

Future aims include the integration of quality of life measurements with patient-reported outcomes as a standard into all phase III cancer clinical trials at the UCT Mainz and the improvement of the infrastructure for high-dimensional data analyses with the formation of a data hub at the UCT Mainz. In addition, we will establish a collaboration with the Sports Science Faculty to investigate the association between physical activity and immune response.

Most significant publications since 2015

  • Renovanz, M., Hickmann, A.K., Nadji-Ohl, M., Keric, N., Weimann, E., Wirtz, C.R., Singer, S., Ringel, F., Coburger, J. 2020. Health-related quality of life and distress in elderly vs. younger patients with high-grade glioma-results of a multicenter study. Support Care Cancer. 28(11), 5165-5175.
  • Leinert, E., Kreienberg, R., Wockel, A., Kuhn, T., Flock, F., Felberbaum, R., Janni, W., Taylor, K., Singer, S., Schwentner, L. 2020. Survivors of primary breast cancer 5 years after surgery: follow-up care, long-term problems, and treatment regrets. Results of the prospective BRENDA II-study. Arch Gynecol Obstet. 301(3), 761-767.
  • Erdmann, F., Hvidtfeldt, U.A., Sørensen, M., Raaschou-Nielsen, O. 2020. Socioeconomic differences in the risk of childhood central nervous system tumors in Denmark: a nationwide register-based case-control study. Cancer Causes Control. 31(10), 915-929.
  • Singer, S., Danker, H., Meixensberger, J., Briest, S., Dietz, A., Kortmann, R.D., Stolzenburg, J.U., Kersting, A., Roick, J. 2019. Structured multi-disciplinary psychosocial care for cancer patients and the perceived quality of care from the patient perspective: a cluster-randomized trial. J Cancer Res Clin Oncol. 145(11):2845-2854. 
  • Ernst, M., Tibubos, A.N., Unterrainer, J., Burghardt, J., Brähler, E., Wild, P.S., Jünger, C., Faber, J., Schneider, A., Beutel, M.E. 2019. Status and predictors of planning ability in adult long-term survivors of CNS tumors and other types of childhood cancer. Sci Rep. 13;9(1):7290.
  • Singer, S., Amdal, C.D., Hammerlid, E., Tomaszewska, I.M., Silva, J.C., Mehanna, H., Santos, M., Inhestern, J., Brannan, C., Yarom, N., Fullerton, A., Pinto, M., Arraras, J.I., Kiyota, N., Bonomo, P., Sherman, A.C., Baumann, I., Galalae, R., Gonzalez, L.F., Nicolatou-Galitis, O., Abdel-Hafeez, Z., Raber-Durlacher, J., Schmalz, C., Zotti, P., Boehm, A., Hofmeister, D., Trivic, S.K., Loo, S., Chie, W.C., Bjordal, K., Herlofson, B.B., Gregoire, V., Licitra, L. 2019. International validation of the revised European Organisation for Research and Treatment of Cancer Head and Neck Cancer Module, the EORTC QLQ-HN43: Phase IV. Head and Neck-Journal for the Sciences and Specialties of the Head and Neck. 41 (6):1725-1737.
  • Byrne, J., Grabow, D., Campbell, H., O'Brien, K., Bielack, S., Am Zehnhoff-Dinnesen, A., Calaminus, G., Kremer, L., Langer, T., van den Heuvel-Eibrink, M.M., van Dulmen-den Broeder, E., Baust, K., Bautz, A., Beck, J.D., Berger, C., Binder, H., Borgmann-Staudt, A., Broer, L., Cario, H., Casagranda, L., Clemens, E., Deuster, D., de Vries, A., Dirksen, U., Winther, J.F., Fosså, S., Font-Gonzalez, A., Grandage, V., Haupt, R., Hecker-Nolting, S., Hjorth, L., Kaiser, M., Kenborg, L., Kepak, T., Kepáková, K., Knudsen, L.E., Krawczuk-Rybak, M., Kruseova, J., Kuehni, C.E., Kunstreich, M., Kuonen, R., Lackner, H., Leiper, A., Loeffen, E.A.H., Luks, A., Modan-Moses, D., Mulder, R., Parfitt, R., Paul, N.W., Ranft, A., Ruud, E., Schilling, R., Spix, C., Stefanowicz, J., Strauβ, G., Uitterlinden, A.G., van den Berg, M., van der Kooi, A.L., van Dijk, M., van Leeuwen, F., Zolk, O., Zöller, D., Kaatsch, P. 2018. PanCareLIFE: The scientific basis for a European project to improve long-term care regarding fertility, ototoxicity and health-related quality of life after cancer occurring among children and adolescents. Eur J Cancer. 103, 227-237.
  • Singer, S., Bartels, M., Briest, S., Einenkel, J., Niederwieser, D., Papsdorf, K., Stolzenburg, J.U., Künstler, S., Taubenheim, S., Krauß, O. 2017. Socio-economic disparities in long-term cancer survival-10 year follow- up with individual patient data. Support Care Cancer. 25(5):1391-1399.
  • Wollschläger, D., Karle, H., Stockinger, M., Bartkowiak, D., Bührdel, S., Merzenich, H., Wiegel, D., Blettner, M., Schmidberger, H. 2016. Radiation dose distribution in functional heart regions from tangential breast cancer radiotherapy. Radiotherapy and Oncology. 119: 65-70.
  • König, J., R. van Ewijk, K. Kuhr, H. Schmidberger, A. Wockel, R. Kreienberg, and M. Blettner. 2016. Radiotherapy effects on early breast cancer survival in observational and randomized studies: a systematic analysis of advantages, disadvantages and differences between the two study types. Breast cancer. 23(3):415-24.
  • Hjorth, L., R. Haupt, R. Skinner, D. Grabow, J. Byrne, S. Karner, G. Levitt, G. Michel, H. van der Pal, E. Bardi, J.D. Beck, F. de Vathaire, S. Essig, E. Frey, S. Garwicz, M. Hawkins, Z. Jakab, M. Jankovic, B. Kazanowska, T. Kepak, L. Kremer, H. Lackner, E. Sugden, M. Terenziani, L.Z. Zaletel, P. Kaatsch, and N. PanCare. 2015. Survivorship after childhood cancer: PanCare: a European Network to promote optimal long-term care. European journal of cancer. 51:1203-1211. 
  • Kaatsch, P., C. Hafner, G. Calaminus, M. Blettner, and M. Tulla. 2015. Pediatric germ cell tumors from 1987 to 2011: incidence rates, time trends, and survival. Pediatrics. 135:e136-143. 

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