Junior group 'Systemic inflammation and vascular disease'
Susanne Karbach, MD, PD
Junior Group Leader
Deputy Group Leader: Dr. med. Johannes Wild
Our group investigates the impact of inflammation mediators on the vasculature and coagulation system. In particular we are interested in the crosstalk between autoimmune disorders and the associated cardiovasular comorbitity of these disorders.
Biography - Susanne Karbach
Positions:Since 2018 – Junior Group Leader 'Systemic inflammation and vascular disease', CTH, University Medical Center of the Johannes Gutenberg-University, Mainz
Since 2016 – Senior Physician (Clinical focus on non-invasive cardiology, heart failure, echocardiography), Center of Cardiology, University Medical Center of the Johannes Gutenberg-University, Mainz
2008 - 2015 – Residency in Internal Medicine / Cardiology, Center of Cardiology, University Medical Center of the Johannes Gutenberg-University, Mainz
Research Career:2020 – Habilitation in Internal Medicine, Center of Cardiology, University Medical Center of the Johannes Gutenberg-University, Mainz
2010 - 2012 – PostDoc (with Prof. Ari Waisman), Institut of Moleculare Medicine, University Medical Center of the Johannes Gutenberg-University, Mainz
Professional Education:2008 – MD, Department of Pharmacology, University Medical Center of the Johannes Gutenberg-University, Mainz
2000 - 2007 – Medical Degree, University Medical Center of the Johannes Gutenberg-University, Mainz, Université de Bourgogne, Dijon, France
ORCID Researcher ID:0000-0003-4462-374 (Karbach)
0000-0002-1446-8101 (Wild)
https://orcid.org/0000-0003-4462-3747
MD Johannes Wild
Funktionen Physician Cardiology I, Deputy Group Leader
06131 17-8036
Annika Lehmann
Funktionen PhD Student
06131 17-8036
Fabienne Ludwig
Funktionen Student Assistant
Lena Schnauder
Funktionen Physician Cardiology I
Matti Schulzke
Funktionen Medical Student
Dr. rer. nat. Rebecca Jung
Dr. rer. nat. Tanja Knopp
Tabea Bieler, M. Sc.
Julia Ringen, Dipl. Chem.
- Role of IL-6 and IL-6-induced cytokines for the interaction of cells and factors of the immune system and blood coagulation
- IL-17A, IL-6 and vasculare dysfunction / inflammation
- Psoriasis and salt-water-homeostasis
- Organ-crosstalk skin-vasculature
Partners of collaboration
Partners at the University Medical Center Mainz
- Prof. Philip Wenzel (CTH)
- Prof. Ari Waisman (Institute for Molecular Medicine)
- Prof. Andreas Daiber (Center for Cardiology – Cardiology I)
- Prof. Bernhard Lämmle (Senior Professor, CTH)
- PD Dr. Kerstin Jurk (CTH)
- Prof. Wolfram Ruf (CTH)
- Jun.-Prof. Christoph Reinhardt (CTH)
- PD Dr. Mareike Lankeit, Dr. Lukas Hobohm (CTH)
- Prof. Huige Li (Department of Pharmacology)
- Prof. Dr. Ellen Closs (Department of Pharmacology)
- Prof. Dr. Markus Radsak (3rd Medical Department, Institute for Immunology)
National Partners
- Prof. Mathias Heikenwälder (DKFZ, Heidelberg)
- Dr. Katharina Kommoss (University Hospital, Heidelberg)
- Prof. Manfred Rauh (University Hospital Erlangen)
- Prof. Dominik Müller (Max-Delbrück-Center of Molecular Medicine, Berlin)
- Prof. Thomas Korn (Experimental Neuroimmunology TU Munich)
- Prof. Ingo Bechmann (Institute of Anatomy, University of Leipzig)
International Partners
- Prof. Jens Titze (DukeNAS Medical School, Singapore)
- Dr. Henry Spronk (CARIM, Maastricht, the Netherlands)
- Prof. Kento Kitada (Kagawa University, Japan)
- DFG TransRegio 156
- BMBF (CTH, 01EO1503)
- DFG (KA 4035/1-1)
- Boehringer Ingelheim Stiftung
- DZHK
- German Heart Foundation
Team - Junior group 'Systemic inflammation and vascular disease'
PD Dr. med. Susanne Karbach, MD
Funktionen Physician Cardiology I, Scientist, Group Leader
- Wild J, Ringen J, Bieler T, Knopp T, Lagrange J, Molitor M, Sies K, Kropp A, Keller K, Daiber A, Münzel T, Rauh M, Waisman A, Wenzel P, Titze J, Karbach S. Epicutaneous Application of Imiquimod to Model Psoriasis-Like Skin Disease Induces Water-Saving Aestivation Motifs and Vascular Inflammation. J Invest Dermatol. 2022 Nov;142(11):3117-3120.e2.
- Maifeld A, Wild J, Karlsen TV, Rakova N, Wistorf E, Linz P, Jung R, Birukov A, Gimenez-Rivera VA, Wilck N, Bartolomaeus T, Dechend R, Kleinewietfeld M, Forslund SK, Krause A, Kokolakis G, Philipp S, Clausen BE, Brand A, Waisman A, Kurschus FC, Wegner J, Schultheis M, Luft FC, Boschmann M, Kelm M, Wiig H, Kuehne T, Müller DN, Karbach S, Markó L. Skin Sodium Accumulates in Psoriasis and Reflects Disease Severity. J Invest Dermatol. 2022 Jan;142(1):166-178.e8.
- Wild J, Jung R, Knopp T, Efentakis P, Benaki D, Grill A, Wegner J, Molitor M, Garlapati V, Rakova N, Markó L, Marton A, Mikros E, Münzel T, Kossmann S, Rauh M, Nakano D, Kitada K, Luft F, Waisman A, Wenzel P, Titze J, Karbach S. Aestivation motifs explain hypertension and muscle mass loss in mice with psoriatic skin barrier defect. Acta Physiol (Oxf). 2021 May;232(1):e13628.
- Karbach S, Hobohm L, Wild J, Münzel T, Gori T, Wegner J, Steinbrink K, Wenzel P, Keller K. Impact of Psoriasis on Mortality Rate and Outcome in Myocardial Infarction. J Am Heart Assoc. 2020 Sep 15;9(18):e016956.
- Wild J, Schüler R, Knopp T, Molitor M, Kossmann S, Münzel T, Daiber A, Waisman A, Wenzel P, Karbach SH. Telmisartan Lowers Elevated Blood Pressure in Psoriatic Mice without Attenuating Vascular Dysfunction and Inflammation. Int J Mol Sci. 2019 Aug 30;20(17):4261.
- Schüler R, Brand A, Klebow S, Wild J, Veras FP, Ullmann E, Roohani S, Kolbinger F, Kossmann S, Wohn C, Daiber A, Münzel T, Wenzel P, Waisman A, Clausen BE, Karbach S. Antagonization of IL-17A Attenuates Skin Inflammation and Vascular Dysfunction in Mouse Models of Psoriasis. J Invest Dermatol 2019;139(3):638-647.
- Uluckan O, Jimenez M, Karbach S, Jeschke A, Grana O, Keller J, Busse B, Croxford AL, Finzel S, Koenders M, van den Berg W, Schinke T, Amling M, Waisman A, Schett G, Wagner EF. Chronic skin inflammation leads to bone loss by il-17-mediated inhibition of wnt signaling in osteoblasts. Science translational medicine 2016 Mar 16;8(330):330ra37.
- Karbach SH, Schönfelder T, Brandão I, Wilms E, Hörmann N, Jäckel S, Schüler R, Finger S, Knorr M, Lagrange J, Brandt M, Waisman A, Kossmann S, Schäfer K, Münzel T, Reinhardt C, Wenzel P. Gut Microbiota Promote Angiotensin II-Induced Arterial Hypertension and Vascular Dysfunction. J Am Heart Assoc. 2016 Aug 30;5(9):e003698.
- Karbach S, Croxford AL, Oelze M, Schüler R, Minwegen D, Wegner J, Koukes L, Yogev N, Nikolaev A, Reissig S, Ullmann A, Knorr M, Waldner M, Neurath MF, Li H, Wu Z, Brochhausen C, Scheller J, Rose-John S, Piotrowski C, Bechmann I, Radsak M, Wild P, Daiber A, von Stebut E, Wenzel P, Waisman A, Münzel T. Interleukin 17 drives vascular inflammation, endothelial dysfunction, and arterial hypertension in psoriasis-like skin disease. Arterioscler Thromb Vasc Biol 2014 Dec;34(12):2658-68.
- Croxford* AL, Karbach* S, Kurschus FC, Wörtge S, Nikolaev A, Yogev N, Klebow S, Schüler R, Reissig S, Piotrowski C, Brylla E, Bechmann I, Scheller J, Rose-John S, Wunderlich FT, Münzel T, von Stebut E, Waisman A. Il-6 regulates neutrophil microabscess formation in IL-17a-driven psoriasiform lesions. J Invest Dermatol 2014 Mar;134(3):728-735. *contributed equally