Translational Research Projects

Flexible funds are essential for the development of new research infrastructures and will enable the CTH to respond to emerging and promising research areas in its strategic development towards a translational research center of excellence. In the final maturation and consolidation of the CTH following the interim review in 2017, the funds will primarily be used for specific projects and enabling technologies with a focus on innovative topics in the field of thrombosis and hemostasis. Scientists in the CTH and its supporting institutions can apply for these flexible funds to approach interdisciplinary projects between CTH Groups or with external collaborations. The program serves to stimulate high risk approaches, establishment of new disease models and research tools that will ultimately facilitate successful third party funding and promote the CTH nationally and internationally. Applications from CTH Junior Scientists are encouraged as an important component of the CTH career development concept. Flexible funds will also be important to provide adequate research support for new recruits of the CTH. The strategic development of the CTH not only depends on interactions within the UMC, but decisively on productive strategic alliances with national and international research centers and groups in the files. Funds for networking, visiting Professorships, and jointly organized meetings will be required to promote the CTH and its research program internationally.

TRP X6 Systems Biology

Prof. Dr. Wolfram Ruf

TRP X7 Platelet Markers for Prothrombotic States

Prof. Dr. Wolfram Ruf

TRP X15 Role of endothelial cells in CTEPH 

Dr. Magdalena Bochenek

TRP X16 Generation of a cell type-specific Pon2 knock-out mouse

Prof. Dr. Andreas Daiber & Prof. Dr. Hartmut Kleinert

TRP X19 Influence of fasting on hemostatic parameters and gut microbiota

Dr. Stefano Barco & Jun.-Prof. Dr. Christoph Reinhardt

TRP X21 Identification of prothrombin expressing cells in the hematopoietic compartment

Prof. Dr. Sven Danckwardt & Dr. Hans Christian Probst

TRP X22 Investigation of α-TFPI in thrombin generation and relation to the cardiovascular profile of the Gutenberg Health Study population

Dr. Marina Panova-Noeva

TRP X23 Role of GLP-1 in vascular inflammation 

Dr. Sebastian Steven & PD Dr. Markus Bosmann

TRP X24 Molecular pathways of venous thromboembolism 

Vincent ten Cate

TRP X25 Protease-mediated Functional Tuning of ‘Clot-busting’ Treg 

PD Dr. Christian Becker

TRP X26 Coagulation Proteinases in human monocyte differentiation

Dr. Verena Raker

TRP X27 In vivo Visualization of Monocytes in Thrombus Formation

Dr. Alexandra Grill

TRP X28 The ENSA/ARPP19-Protein Phosphatase 2A (PP2A) system

PD Dr. Kerstin Jurk

TRP X29 The role of B lymphocytes in venous thrombosis

Prof. Dr. Huige Li

TRP X30 Gut epithelial coagulation factors in intestinal barrier function

Jun.-Prof. Dr. Christoph Reinhardt 

TRP X31 Transcriptome signatures in obesity

Prof. Dr. Wolfram Ruf & Prof. Dr. Philipp Wild

TRP X32 Importance of EPCR expression for vessel formation

Prof. Dr. Katrin Schäfer & Dr. Magdalena Bochenek

TRP X33 Protease-selective signaling via PAR2 in metabolic adaptation

Dr. Madhusudhan Thati

TRP X34 The chronification of acute pulmonary embolisms in small animals

Dr. Moritz Brandt

TRP X35 Megakaryocyte transcriptome profiling

Dr. Angela Dörr & Dr. Federico Marini

TRP X36 Integrated multi-omics analyses elucidating mechanisms of type 2 diabetes mellitus

Prof. Dr. Philipp Wild

TRP X37 Platelet activation induced by antiphospholipid antibodies

Dr. Nadine Müller-Calleja & Anne Hollerbach

TRP X38 Endothelial glycocalyx in vascular inflammation and ageing.

Prof. Dr. Philip Wenzel

TRP X39 Role of PAR2 in C5a-induced lung injury

Dr. Sarah Walachowski

TRP X40 Hormonal status and link to hypercoagulability in adult survivors of childhood cancer

Dr. Marina Panova-Noeva

TRP X41 Digital spatial monocyte expression profiling in varicose veins

Dr. Fatemeh Shahneh

TRP X42 The role of inflammation for venous thromboembolic events

Lisa Eggebrecht

TRP X43 New signaling and functional targets of the cAMP/PKA and cGMP/PKG pathways in human and mouse platelets

Dr. Elena Kumm

TRP X44 Underlying mechanisms of the transient serine phosphorylation and activity of platelet Syk

Dr. Stephanie Makhoul

TRP X45 Role of protease-activated receptor 1 (PAR1) and Toll-like receptor 4 (TLR4) in small intestine renewal and remodeling mediated by bone morphogenetic protein 2 (BMP2)

Giulia Pontarollo, PhD

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Completed TRP projects

TRP Committee

PD Dr. Christian Becker

Dr. Stefano Barco

Prof. Huige Li

PD Kerstin Jurk

Dr. Susanne Karbach

Dr. Marina Panova-Noeva

Prof. Dr. Katrin Schäfer

Dr. Hanne Battermann (Administration)