Juniorprofessorship 'Systems Interactions of Hemostasis'

Assistant Professor for Systems Interactions of Hemostasis

Jun. Prof. Dr. Carsten Deppermann

Platelets are small, anucleate cells that patrol the vasculature to immediately respond to vessel breaches and restore hemostasis. There has been accumulating evidence that platelets also interact with and regulate cells of the (innate) immune system. It is now accepted that they play roles beyond hemostasis and contribute to thromboinflammatory processes in disease.

We are currently employing intravital microscopy, tissue clearing, primary cell culture, flow cytometry and other state-of-the-art techniques to understand the complex interplay between platelets and the innate immune system in the liver, kidney and intestine under (patho)physiologic conditions. We are also studying the mechanisms through which platelet clearance in health and disease feeds back to platelet production by megakaryocytes in the bone marrow.

Research Funding

• BMBF 'Clusters4Future' (curATime; P7 megATarget)
• DFG (SFB 1292 TP08)
• DFG (Emmy Noether-Program)

Biography - Carsten Deppermann

Positions:
Since 2021 – Assistant Professor for Systems Interactions of Hemostasis, CTH, University Medical Center of the Johannes Gutenberg-University, Mainz
2019 - 2021 – Group Leader, Institute of Clinical Chemistry and Laboratory Medicine, University Medical Centre Hamburg-Eppendorf

Research Career:
2016 - 2019 – Postdoctoral Fellow (with Prof. Dr. Paul Kubes), Snyder Institute for Chronic Diseases, Calgary, Canada, DFG Research Fellowship

Professional Education:
2011 - 2015 – PhD, Experimental Biomedicine, Rudolf Virchow Centre, Würzburg, Supervisor Prof. Dr. Bernhard Nieswandt
2005 - 2010 – Studies in Biochemistry, University of Frankfurt/Main, Master (Diplom), Thesis Supervisor Prof. Dr. Mirko Schmidt

Researcher IDs:
ORCID: 0000-0003-3740-8635
Google Scholar: Link

Twitter:
Link

Team - Juniorprofessorship Systems Interactions of Hemostasis

We are currently looking for motivated Master, MD or PhD students. Students with interests in platelet/cell biology, innate immunity and microscopy are encouraged to apply via e-mail to deppermann@uni-mainz.de including a letter of motivation and CV.

Original articles

• Karwen T, Kolczynska-Matysiak K, Gross C, Löffler MC, Friedrich M, Loza-Valdes A, Schmitz W, Wit M, Dziaczkowski F, Belykh A, Trujillo-Viera J, El-Merahbi R, Deppermann C, Nawaz S, Hastoy B, Demczuk A, Erk M, Wieckowski MR, Rorsman P, Heinze KG, Stegner D, Nieswandt B, Sumara G. Platelet-derived lipids promote insulin secretion of pancreatic β cells. EMBO Mol Med. 2023 Sep 11;15(9):e16858.
• Pontarollo G, Kollar B, Mann A, Khuu MP, Kiouptsi K, Bayer F, Brandão I, Zinina VV, Hahlbrock J, Malinarich F, Mimmler M, Bhushan S, Marini F, Ruf W, Belheouane M, Baines JF, Endres K, Reba SM, Raker VK, Deppermann C, Welsch C, Bosmann M, Soshnikova N, Chassaing B, Bergentall M, Sommer F, Bäckhed F, Reinhardt C. Commensal bacteria weaken the intestinal barrier by suppressing epithelial neuropilin-1 and Hedgehog signaling. Nat Metab. 2023 Jul;5(7):1174-1187. 
• Heestermans M, Naudin C, Mailer RK, Konrath S, Klaetschke K, Jämsä A, Frye M, Deppermann C, Pula G, Kuta P, Friese MA, Gelderblom M, Sickmann A, Preston RJS, Nofer JR, Rose-John S, Butler LM, Salomon O, Stavrou EX, Renné T. Identification of the factor XII contact activation site enables sensitive coagulation diagnostics. Nat Commun. 2021 Sep 22;12(1):5596.
• Englert H, Rangaswamy C, Deppermann C, Sperhake JP, Krisp C, Schreier D, Gordon E, Konrath S, Haddad M, Pula G, Mailer RK, Schlüter H, Kluge S, Langer F, Püschel K, Panousis K, Stavrou EX, Maas C, Renné T and Frye M. Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation. EBioMedicine 2021 May;67:103382
• Zindel J, Peiseler M, Hossain M, Deppermann C, Lee WY, Haenni B, Zuber B, Deniset JF, Surewaard BGJ, Candinas D and Kubes P. Primordial GATA6 macrophages function as extravascular platelets in sterile injury. Science. 2021 Mar 5;371(6533):eabe0595) 
• Mailer RK, Allende M, Heestermans M, Schweizer M, Deppermann C, Frye M, Pula G, Odeberg J, Gelderblom M, Rose-John S, Sickmann A, Blankenberg S, Huber T, Kubisch C, Maas C, Gambaryan S, Firsov S, Stavrou EX, Butler L and Renné T. Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate. Blood. 2021 Mar 11;137(10):1392-1405
• Deppermann C*, Peiseler M*, Zindel J, Zbytnuik L, Lee WY, Pasini E, Baciu C, Matelski J, Lee Y, Kumar D, Humar A, Surewaard B, Kubes P and Bhat M. Tacrolimus impairs Kupffer cell capacity to control bacteremia: why transplant recipients are susceptible to infection. Hepatology. 2021 May;73(5):1967-1984. *equal contribution
• Deppermann C, Kratofil RM, Peiseler M, David BA, Zindel J, Castanheira FVES, van der Wal F, Carestia A, Jenne CN, Marth JD and Kubes P. Macrophage galactose lectin is critical for Kupffer cells to clear aged platelets. J. Exp. Med. 2020 Apr 6;217(4):e20190723
• Jorch SK, Surewaard BGJ, Hossain M, Peiseler M, Deppermann C, Deng J, Bogoslowski A, van der Wal F, Omri A, Hickey MJ and Kubes P. GATA6+ macrophages in the peritoneum function as a portal for Staphylococcus aureus dissemination. J. Clin. Invest. 2019 Nov 1;129(11):4643-4656.
• Deniset JF, Belke D, Lee W-Y, Jorch SK, Deppermann C, Hassanabad AF, Turnbull JD, Teng G, Rozich I, Hudspeth K, Kanno Y, Brooks SR, Hadjantonakis A-K, O’Shea JJ, Weber GF, Fedak PWM and Kubes P. Gata6+ Pericardial Cavity Macrophages Relocate to the Injured Heart and Prevent Cardiac Fibrosis. Immunity 2019 Jul 16;51(1):131-140.e5.
• Malehmir M, Pfister D, Gallage S, Szydlowska M, Inverso D, Kotsiliti E, Leone V, Peiseler M, Surewaard B, Rath D, Ali S, Wolf M, Drescher H, Healy M, Dauch D, Kroy D, Krenkel O, Kohlhepp M, Engleitner T, Olkus A, Sijmonsma T, Volz J, Deppermann C, Stegner D, Helbling P, Nombela-Arrieta C, Rafiei A, Hinterleitner M, Rall M, Baku F, Borst O, Wilson CL, Leslie J, O’Connor T, Weston CJ, Adams DH, Sheriff L, Teijeiro A, Prinz M, Bogeska R, Anstee N, Bongers MN, Notohamiprodjo M, Geisler T, Withers DJ, Ware J, Mann DA, Augustin HG, Vegiopoulos A, Milsom MD, Rose AJ, Lalor PF, Llovet JM, Pinyol R, Tacke F, Rad R, Matter M, Djouder N, Kubes P, Knolle PA, Unger K, Zender L, Nieswandt B, Gawaz M, Weber A and Heikenwälder M. Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer. Nat. Medicine 2019 Apr;25(4):641-655.
• Gotru SK, van Geffen JP, Nagy M, Mammadova-Bach E, Eilenberger J, Volz J, Manukjan G, Schulze H, Wagner L, Eber S, Schambeck C, Deppermann C, Brouns S, Nurden P, Greinacher A, Sachs U, Nieswandt B, Hermanns HM, Heemskerk JWM and Braun A. Defective Zn2+ homeostasis in mouse and human platelets with α- and δ-storage pool diseases. Sci. Rep. 2019 Jun 6;9(1):8333.
• Surewaard BGJ, Thanabalasuriar A, Zeng Z, Tkaczyk C, Cohen TS, Bardoel BW, Jorch SK, Deppermann C, Bubeck Wardenburg J, Davis RP, Jenne CN, Stover KC, Sellman BR and Kubes P. α-Toxin Induces Platelet Aggregation and Liver Injury during Staphylococcus aureus Sepsis. Cell Host Microbe. 2018 Aug 8;24(2):271-284.e3.
• Drube S, Grimlowski R, Deppermann C, Fröbel J, Kraft F, Andreas N, Stegner D, Dudeck J, Weber F, Rödiger M, Göpfert C, Drube J, Reich D, Nieswandt B, Dudeck A and Kamradt T. The Neurobeachin-like 2 protein (Nbeal2) regulates mast cell homeostasis. J. Immunol. 2017 Oct 15;199(8):2948-2957.
• Deppermann C, Kraft P, Volz J, Schuhmann MK, Beck S, Wolf K, Stegner D, Stoll G and Nieswandt B. Platelet secretion is crucial to prevent bleeding in the ischemic brain but not in the inflamed skin or lung in mice. Blood. 2017 Mar 23;129(12):1702-1706.
• Pachel C, Mathes D, Arias-Loza A-P, Heitzmann W, Nordbeck P, Deppermann C, Lorenz V, Hofmann U, Nieswandt B and Frantz S. Inhibition of platelet GPVI protects against myocardial ischemia-reperfusion injury. Arterioscler. Thromb. Vasc. Biol. 2016 Apr;36(4):629-35.
• Lowe KL, Finney BA, Deppermann C, Hagerling R, Gazit SL, Frampton J, Buckley CD, Camerer E, Nieswandt B, Kiefer F and Watson SP. Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development. Blood. 2015 Jun 11;125(24):3769-77.
• Kraft P, Göb E, Schuhmann MK, Göbel K, Deppermann C, Thielmann I, Herrmann AM, Lorenz K, Brede M, Stoll G, Meuth SG, Nieswandt B, Pfeilschifter W and Kleinschnitz C. FTY720 ameliorates acute ischemic stroke in mice by reducing thrombo-inflammation but not by direct neuroprotection. Stroke 2013 Nov;44(11):3202-10.
• Stegner D*, Deppermann C*, Kraft P, Morowski M, Kleinschnitz C, Stoll G and Nieswandt B. Munc13-4 mediated secretion is essential for infarct progression but not intracranial haemostasis in acute stroke. J. Thromb. Haemost. 2013 Jul;11(7):1430-3. *equal contribution 
• Deppermann C, Cherpokova D, Nurden P, Schulz JN, Thielmann I, Kraft P, Vögtle T, Kleinschnitz C, Dütting S, Krohne G, Eming S, Nurden A, Eckes B, Stoll G, Stegner D and Nieswandt B. Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice. J. Clin. Invest. 2013 Jul 1;123(8):3331–42.

Reviews

• An O, Deppermann C. Platelet lifespan and mechanisms for clearance. Curr Opin Hematol. 2024 Jan 1;31(1):6-15. 
• Casari M, Siegl D, Deppermann C, Schuppan D. Macrophages and platelets in liver fibrosis and hepatocellular carcinoma. Front Immunol. 2023 Dec 5;14:1277808. 
• Kiouptsi K, Casari M, Mandel J, Gao Z, Deppermann C. Intravital Imaging of Thrombosis Models in Mice. Hamostaseologie. 2023 Oct;43(5):348-359. 
• Mandel J, Casari M, Stepanyan M, Martyanov A, Deppermann C. Beyond Hemostasis: Platelet Innate Immune Interactions and Thromboinflammation. Int J Mol Sci. 2022 Mar 31;23(7):3868. 
• Rangaswamy C, Englert H, Deppermann C, Renné T. Polyanions in Coagulation and Thrombosis: Focus on Polyphosphate and Neutrophils Extracellular Traps. Thromb Haemost. 2021 Aug;121(8):1021-1030.
• Jorch SK and Deppermann C. Intravital Imaging Allows Organ-Specific Insights Into Immune Functions. Front. Cell. Dev. Biol. 2021 Feb 11;9:623906.
• Martinod K and Deppermann C. Immunothrombosis and thromboinflammation in host defense and disease. Platelets. 2021 Apr 3;32(3):314-324.
• Rangaswamy C, Englert H, Deppermann C, Renné T. Polyanions in Coagulation and Thrombosis: Focus on Polyphosphate and Neutrophils Extracellular Traps. Thromb. Haemost. 2021 Aug;121(8):1021-1030.
• Deppermann C and Kubes P. Start a fire, kill the bug: The role of platelets in inflammation and infection. Innate Immun. 2018 Aug;24(6):335-348.
• Deppermann C. Platelets and vascular integrity. Platelets. 2018 Sep;29(6):549-555.
• Deppermann C and Kubes P. Platelets and infection. Semin. Immunol. 2016 Dec;28(6):536-545.
• Deppermann C, Nurden P, Nurden AT, Nieswandt B and Stegner D. The Nbeal2-/- mouse as a model for the gray platelet syndrome. Rare Dis. 2013 Sep 26;1:e26561.