TRP X34 The chronification of acute pulmonary embolisms in small animals: novel non-invasive monitoring methodologies and the role of defective telomere homeostasis
Funding period: 01.08.2019 – 31.07.2020
Project Summary
Our proposed project consists of two aims, both based on our previously established model of thrombus persistence after repetitive pulmonary embolisms resulting in elevated pulmonary pressure, pulmonary arterial endothelial dysfunction and increased ROS. Aim 1 will expand our model to enable noninvasive assessment of thrombus burden in correlation with right ventricular dysfunction. Aim 2 will take advantage of the same experimental setup and investigate the interplay of thrombus persistence, pulmonary hypertension, increased ROS and telomere homeostasis.
Principal Investigator
Jan Moritz Brandt, MD
Physician Cardiology I, Clinician Scientist, CHANCE Fellow