Publikationen 2023

Abdel-Hady BM, Ekram B, Müller WEG, Aziz GAM, Wang XH, Schröder HC, Tolba E. Ascorbyl palmitate–PCL fiber mats loaded with strontium polyphosphate nanoparticles for guided bone regeneration. Polym. Bull. (2023) 81:1-20

Anyaegbunam UA, More P, Fontaine JF, Cate VT, Bauer K, Distler U, Araldi E, Bindila L, Wild P, Andrade-Navarro MA. A Systematic Review of Lipid-Focused Cardiovascular Disease Research: Trends and Opportunities. Curr Issues Mol Biol. 2023 Dec 9;45(12):9904-9916. doi: 10.3390/cimb45120618. PMID: 38132464; PMCID: PMC10742042.

Avraamidou E, Nöthel M, Danisch M, Bindila L, Schmidt SV, Lutz B, Nickenig G, Jehle J. Myeloid But Not Endothelial Expression of the CB2 Receptor Promotes Atherogenesis in the Context of Elevated Levels of the Endocannabinoid 2-Arachidonoylglycerol. J Cardiovasc Transl Res. 2023 Apr;16(2):491-501. doi: 10.1007/s12265-022-10323-z. Epub 2022 Sep 30. PMID: 36178662; PMCID: PMC10151305.

Beltrán Arranz A, Berninger B. Seizing hope: Advancing cell therapy for pharmaco-resistant epilepsy toward the clinic. Cell Stem Cell. 2023 Oct 5;30(10):1287-1289. doi: 10.1016/j.stem.2023.08.006. PMID: 37802033.

Bernáez Timón L, Ekelmans P, Kraynyukova N, Rose T, Busse L, Tchumatchenko T. How to incorporate biological insights into network models and why it matters. J Physiol. 2023 Aug;601(15):3037-3053. doi: 10.1113/JP282755. Epub 2022 Sep 25. PMID: 36069408.

Butto T, Mungikar K, Baumann P, Winter J, Lutz B, Gerber S. Nuclei on the Rise: When Nuclei-Based Methods Meet Next-Generation Sequencing. Cells. 2023 Mar 30;12(7):1051. doi: 10.3390/cells12071051. PMID: 37048124; PMCID: PMC10093037.

Chen JY, Li Q, He QF, Schröder HC, Lu ZJ, Yuan DX. Influence of CO2/HCO3− on Microbial Communities in Two Karst Caves with High CO2. J. Earth Sci. 2023; 34, 145–155.

Eggl MF, Chater TE, Petkovic J, Goda Y, Tchumatchenko T. Linking spontaneous and stimulated spine dynamics. Commun Biol. 2023 Sep 11;6(1):930. doi: 10.1038/s42003-023-05303-1. PMID: 37696988; PMCID: PMC10495434.

Ekelmans P, Kraynyukova N, Tchumatchenko T. Targeting operational regimes of interest in recurrent neural networks. PLoS Comput Biol. 2023 May 15;19(5):e1011097. doi: 10.1371/journal.pcbi.1011097. PMID: 37186668; PMCID: PMC10212141.

Fan W, Jurado-Arjona J, Alanis-Lobato G, Péron S, Berger C, Andrade-Navarro MA, Falk S, Berninger B. The transcriptional co-activator Yap1 promotes adult hippocampal neural stem cell activation. EMBO J. 2023 Jun 1;42(11):e110384. doi: 10.15252/embj.2021110384. Epub 2023 Apr 21. PMID: 37083045; PMCID: PMC10233373.

Felske T, Tocco C, Péron S, Harb K, Alfano C, Galante C, Berninger B, Studer M. Lmo4 synergizes with Fezf2 to promote direct in vivo reprogramming of upper layer cortical neurons and cortical glia towards deep-layer neuron identities. PLoS Biol. 2023 Aug 8;21(8):e3002237. doi: 10.1371/journal.pbio.3002237. PMID: 37552690; PMCID: PMC10409279.

Galante C, Marichal N, Scarante FF, Ghayad LM, Shi Y, Schuurmans C, Berninger B, Péron S. Enhanced proliferation of oligodendrocyte progenitor cells following retrovirus mediated Achaete-scute complex-like 1 overexpression in the postnatal cerebral cortex in vivo. Front Neurosci. 2022 Dec 2;16:919462. doi: 10.3389/fnins.2022.919462. Erratum in: Front Neurosci. 2023 Apr 18;17:1198640. PMID: 36532282; PMCID: PMC9755855.

Guan X, Li Q, Jiang H, Müller WEG. Editorial: Ecological distribution, functional diversity, and the biogeochemical cycle of microorganisms in karst. Front Microbiol. 2023 Aug 11;14:1265640. doi: 10.3389/fmicb.2023.1265640. PMID: 37637127; PMCID: PMC10454899.

Hasegawa Y, Kim J, Ursini G, Jouroukhin Y, Zhu X, Miyahara Y, Xiong F, Madireddy S, Obayashi M, Lutz B, Sawa A, Brown SP, Pletnikov MV, Kamiya A. Microglial cannabinoid receptor type 1 mediates social memory deficits in mice produced by adolescent THC exposure and 16p11.2 duplication. Nat Commun. 2023 Oct 25;14(1):6559. doi: 10.1038/s41467-023-42276-5. PMID: 37880248; PMCID: PMC10600150.

Hatt LP, Armiento AR, Mys K, Thompson K, Hildebrand M, Nehrbass D, Müller WEG, Zeiter S, Eglin D, Stoddart MJ. Standard in vitro evaluations of engineered bone substitutes are not sufficient to predict in vivo preclinical model outcomes. Acta Biomater. 2023 Jan 15;156:177-189. doi: 10.1016/j.actbio.2022.08.021. Epub 2022 Aug 19. PMID: 35988660.

Khamrin P, Pham NTK, Shimizu-Onda Y, Trinh QD, Hoque SA, Kumthip K, Nomura A, Okitsu S, Maneekarn N, Müller WEG, Hayakawa S, Ushijima H. Evaluation of an Immunochromatographic Test for Rapid Detection of Astrovirus in Acute Gastroenteritis Pediatric Patients. Clin Lab. 2023 Aug 1;69(8). doi: 10.7754/Clin.Lab.2023.230314. PMID: 37560869.

Martínez-Torres S, Bergadà-Martínez A, Ortega JE, Galera-López L, Hervera A, de Los Reyes-Ramírez L, Ortega-Álvaro A, Remmers F, Muñoz-Moreno E, Soria G, Del Río JA, Lutz B, Ruíz-Ortega JÁ, Meana JJ, Maldonado R, Ozaita A. Peripheral CB1 receptor blockade acts as a memory enhancer through a noradrenergic mechanism. Neuropsychopharmacology. 2023 Jan;48(2):341-350. doi: 10.1038/s41386-022-01436-9. Epub 2022 Sep 10. PMID: 36088492; PMCID: PMC9750989.

Masetto T, Matzenbach K, Reuschel T, Tölke SA, Schneider K, Esser LM, Reinhart M, Bindila L, Peter C, Grimmler M. Comprehensive Comparison of the Capacity of Functionalized Sepharose, Magnetic Core, and Polystyrene Nanoparticles to Immuno-Precipitate Procalcitonin from Human Material for the Subsequent Quantification by LC-MS/MS. Int J Mol Sci. 2023 Jun 30;24(13):10963. doi: 10.3390/ijms241310963. PMID: 37446139; PMCID: PMC10341910.

Masnikosa R, Pirić D, Post JM, Cvetković Z, Petrović S, Paunović M, Vučić V, Bindila L. Disturbed Plasma Lipidomic Profiles in Females with Diffuse Large B-Cell Lymphoma: A Pilot Study. Cancers (Basel). 2023 Jul 18;15(14):3653. doi: 10.3390/cancers15143653. PMID: 37509314; PMCID: PMC10377844.

Miederer I, Schmitt U, Bausbacher N, Röhrich J, Mildenberger P, Lutz B, Tüscher O, Schreckenberger M. Chronic Administration of Δ9-Tetrahydrocannabinol Alters Brain Glucose Uptake and Improves Waiting Impulsivity in the Rat. Cannabis Cannabinoid Res. 2023 Feb 17. doi: 10.1089/can.2022.0268. Epub ahead of print. PMID: 36800226.

Müller WE G, Schepler H, Neufurth M, Wang SF, Ferrucci V, Zollo M, Tan RW, Schroeder HC, Wang XH. The physiological polyphosphate as a healing biomaterial for chronic wounds: Crucial roles of its antibacterial and unique metabolic energy supplying properties. Journal of Materials Science & Technology. 2023; 135: 170-185.

Müller, W.E.G., Wang, S., Neufurth, M., Schröder, H.C., Wang, X. (2023). Physiological polyphosphate: A new molecular paradigm in biomedical and biocomputational applications for human therapy. In: Rojas, I., Valenzuela, O., Rojas Ruiz, F., Herrera, L.J., Ortuño, F. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2023. Computer Science, Springer: Cham; 13919: 542-559.

Palmisano M, Gargano A, Olabiyi BF, Lutz B, Bilkei-Gorzo A. Hippocampal Deletion of CB1 Receptor Impairs Social Memory and Leads to Age-Related Changes in the Hippocampus of Adult Mice. Int J Mol Sci. 2022 Dec 20;24(1):26. doi: 10.3390/ijms24010026. PMID: 36613469; PMCID: PMC9819823.

Péron S, Miyakoshi LM, Brill MS, Manzano-Franco D, Serrano-López J, Fan W, Marichal N, Ghanem A, Conzelmann KK, Karow M, Ortega F, Gascón S, Berninger B. Programming of neural progenitors of the adult subependymal zone towards a glutamatergic neuron lineage by neurogenin 2. Stem Cell Reports. 2023 Dec 12;18(12):2418-2433. doi: 10.1016/j.stemcr.2023.10.019. Epub 2023 Nov 22. PMID: 37995703; PMCID: PMC10724369.

Schmitt D, Bozkurt S, Henning-Domres P, Huesmann H, Eimer S, Bindila L, Behrends C, Boyle E, Wilfling F, Tascher G, Münch C, Behl C, Kern A. FACS-mediated isolation of native autophagic vesicles. Autophagy. 2023 Jul;19(7):2146-2147. doi: 10.1080/15548627.2022.2151188. Epub 2022 Nov 29. PMID: 36416088; PMCID: PMC10283435.

Schwitter C, Lutz B, Bindila L. Extraction and Simultaneous Quantification of Endocannabinoids and Endocannabinoid-Like Lipids in Biological Tissues. Methods Mol Biol. 2023;2576:9-19. doi: 10.1007/978-1-0716-2728-0_2. PMID: 36152174.

Skupio U, Welte J, Serrat R, Eraso-Pichot A, Julio-Kalajzić F, Gisquet D, Cannich A, Delcasso S, Matias I, Fundazuri UB, Pouvreau S, Pagano Zottola AC, Lavanco G, Drago F, Ruiz de Azua I, Lutz B, Bellocchio L, Busquets-Garcia A, Chaouloff F, Marsicano G. Mitochondrial cannabinoid receptors gate corticosterone impact on novel object recognition. Neuron. 2023 Jun 21;111(12):1887-1897.e6. doi: 10.1016/j.neuron.2023.04.001. Epub 2023 Apr 24. PMID: 37098353.

Sousa N, Geiß C, Bindila L, Lieberwirth I, Kim E, Régnier-Vigouroux A. Targeting sphingolipid metabolism with the sphingosine kinase inhibitor SKI-II overcomes hypoxia-induced chemotherapy resistance in glioblastoma cells: effects on cell death, self-renewal, and invasion. BMC Cancer. 2023 Aug 16;23(1):762. doi: 10.1186/s12885-023-11271-w. PMID: 37587449; PMCID: PMC10433583.

Tevosian M, Todorov H, Lomazzo E, Bindila L, Ueda N, Bassetti D, Warm D, Kirischuk S, Luhmann HJ, Gerber S, Lutz B. NAPE-PLD deletion in stress-TRAPed neurons results in an anxiogenic phenotype. Transl Psychiatry. 2023 May 6;13(1):152. doi: 10.1038/s41398-023-02448-9. PMID: 37149657; PMCID: PMC10164145.

Tölke SA, Masetto T, Reuschel T, Grimmler M, Bindila L, Schneider K. Immunoaffinity LC-MS/MS Quantification of the Sepsis Biomarker Procalcitonin Using Magnetic- and Polystyrene-Bead Immobilized Polyclonal Antibodies. J Proteome Res. 2023 Oct 6;22(10):3135-3148. doi: 10.1021/acs.jproteome.3c00082. Epub 2023 Sep 6. PMID: 37672672.

Tundidor I, Seijo-Vila M, Blasco-Benito S, Rubert-Hernández M, Adámez S, Andradas C, Manzano S, Álvarez-López I, Sarasqueta C, Villa-Morales M, González-Lois C, Ramírez-Medina E, Almoguera B, Sánchez-López AJ, Bindila L, Hamann S, Arnold N, Röcken C, Heras-Murillo I, Sancho D, Moreno-Bueno G, Caffarel MM, Guzmán M, Sánchez C, Pérez-Gómez E. Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer. Nat Commun. 2023 May 30;14(1):3130. doi: 10.1038/s41467-023-38750-9. PMID: 37253733; PMCID: PMC10229544.

Wagle S, Kraynyukova N, Hafner AS, Tchumatchenko T. Computational insights into mRNA and protein dynamics underlying synaptic plasticity rules. Mol Cell Neurosci. 2023 Jun;125:103846. doi: 10.1016/j.mcn.2023.103846. Epub 2023 Mar 22. PMID: 36963534; PMCID: PMC10274545.

Wang SF, Neufurth M, Schepler H, Tan RW, She ZD, Al-Nawas B, Wang XH, Schröder HC, Müller WEG. Acceleration of Wound Healing through Amorphous Calcium Carbonate, Stabilized with High-Energy Polyphosphate. Pharmaceutics. 2023 Feb 2;15(2):494. doi: 10.3390/pharmaceutics15020494. PMID: 36839816; PMCID: PMC9961744.

Publikationen 2021

Ahrens KF, Neumann RJ, Kollmann B, Brokelmann J, von Werthern NM, Malyshau A, Weichert D, Lutz B, Fiebach CJ, Wessa M, Kalisch R, Plichta MM, Lieb K, Tüscher O, Reif A (2021) Impact of COVID-19 lockdown on mental health in Germany: longitudinal observation of different mental health trajectories and protective factors. Transl Psychiatry. 2021 Jul 17;11(1):392. 

Alkaabi SA, Natsir Kalla DS, Alsabri GA, Fauzi A, Tajrin A, Müller WEG, Schröder HC, Wang XH, Forouzanfar T, Helder MN, Ruslin M (2021) Polyphosphate (PolyP) for alveolar cleft repair: study protocol for a pilot randomized controlled trial. Trials 22:393

Alkaabi S, Kalla N, Alsabri GA, Fauzi A, NA J, Tajrin A, Müller WEG, Schröder HC, Wang XH, Forouzanfar T, Helder MN, Ruslin M (2021) Safety and feasibility study of using polyphosphate (PolyP) in alveolar cleft repair: A pilot study. Research Square, doi: 10.21203/

Ariantari NP, Frank M, Gao Y, Stuhldreier F, Hartmann R, Höfert SP, Janiak C, Wesselborg S, Müller WEG, Kalscheuer R, Liu Z, Proksch P (2021) Fusaristatins D–F and (7S,8R)-(–)-chlamydospordiol from Fusarium sp. BZCB-CA, an endophyte of Bothriospermum chinenseTetrahedron 85:132065

Auer MK, Gebert D, Biedermann SV, Bindila L, Stalla G, Reisch N, Kopczak A, Fuss J (2021) Altered endocannabinoid-dynamics in craniopharyngioma patients and their association with HPA-axis disturbances. Eur J Endocrinol. 2021 Jul 1;185(2):231-239. 

Chmitorz A, Neumann RJ, Kollmann B, Ahrens KF, Öhlschläger S, Goldbach N, Weichert D, Schick A, Lutz B, Plichta MM, Fiebach CJ, Wessa M, Kalisch R, Tüscher O, Lieb K, Reif A (2021) Longitudinal determination of resilience in humans to identify mechanisms of resilience to modern-life stressors: the longitudinal resilience assessment (LORA) study. Eur Arch Psychiatry Clin Neurosci. 2020 Jul 18. doi: 10.1007/s00406-020-01159-2. Epub ahead of print. PMID: 32683526.

De Giacomo V, Ruehle S, Lutz B, Häring M, Remmers F (2021) Differential glutamatergic and GABAergic contributions to the tetrad effects of Δ9-tetrahydrocannabinol revealed by cell-type-specific reconstitution of the CB1 receptor. Neuropharmacology 179:108287. doi: 10.1016/j.neuropharm.2020.108287.

El-Kashef DH, Youssef FS, Reimche I, Teusch N, Müller WEG, Lin WH, Frank M, Liu Z, Proksch P (2021) Polyketides from the marine-derived fungus Aspergillus falconensis: In silico and in vitro cytotoxicity studies. Bioorg Med Chem 29:115883

Jehle J, Eich L, Danisch M, Bagheri S, Avraamidou E, Pfeifer P, Tiyerili V, Bindila L, Lutz B, Nickenig G (2021) The endocannabinoid 2-arachidonoylglycerol inhibits endothelial function and repair. Int J Cardiol 323:243-250. doi: 10.1016/j.ijcard.2020.08.042.

Kodirov SA, Bonni K, Wehrmeister M, Lutz B (2021) Depolarization-initiated endogenous cannabinoid release and underlying retrograde neurotransmission in interneurons of amygdala. Learn Mem. 2021 Jan 15;28(2):44-52. 

Leschik J, Lutz B, Gentile A (2021) Stress-Related Dysfunction of Adult Hippocampal Neurogenesis-An Attempt for Understanding Resilience? Int J Mol Sci. 2021 Jul 8;22(14):7339. 

Li Q, Song A, Yang H, Müller WEG (2021) Impact of rocky desertification control on soil bacterial community in Karst Graben Basin, southwestern China. Front Microbiol 12:636405 

Milic M, Schmitt U, Lutz B, Müller MB (2021) Individual baseline behavioral traits predict the resilience phenotype after chronic social defeat. Neurobiol Stress. 2020 Dec 29;14:100290. 

More P, Bindila L, Wild P, Andrade-Navarro M, Fontaine JF (2021) LipiDisease: associate lipids to diseases using literature mining. Bioinformatics. 2021 Aug 6:btab559. 

Müller WEG, Neufurth M, Lieberwirth I, Muñoz-Espí R, Wang SF, Schröder HC, Wang XH (2021) Triple-target stimuli-responsive anti-COVID-19 face mask with physiological virus-inactivating agents. Biomater Sci; doi: 10.1039/d1bm00502b

Müller WEG, Neufurth M, Wang SF, Schröder HC, Wang XH (2021) Polyphosphate reverses the toxicity of the quasi-enzyme Bleomycin on alveolar endothelial lung cells in vitroCancers 13: 750

Müller WEG, Schröder HC, Neufurth M, Wang XH (2021) An unexpected biomaterial against SARS-CoV-2: Bio-polyphosphate blocks binding of the viral spike to the cell receptor. Materials Today; in press. doi: 10.1016/j.mattod.2021.07.029

Musayeva A, Jiang S, Ruan Y, Zadeh JK, Chronopoulos P, Pfeiffer N, Müller WEG, Ackermann M, Xia N, Li H, Gericke A (2021) Aged mice devoid of the M3 muscarinic acetylcholine receptor develop mild dry eye disease. Int J Mol Sci 22:6133.

Navandar M, Martín-García E, Maldonado R, Lutz B, Gerber S, Ruiz de Azua I (2021) Transcriptional signatures in prefrontal cortex confer vulnerability versus resilience to food and cocaine addiction-like behavior. Sci Rep. 2021 Apr 27;11(1):9076.

Neufurth M, Wang XH, Wang SF, Schröder HC, Müller WEG (2021) Caged dexamethasone/quercetin nanoparticles, formed of the morphogenetic active inorganic polyphosphate, are strong inducers of MUC5ACMar Drugs 19:64.

Pascual Cuadrado D, Wierczeiko A, Hewel C, Gerber S, Lutz B (2021) Dichotomic Hippocampal Transcriptome After Glutamatergic vs. GABAergic Deletion of the Cannabinoid CB1 Receptor. Front Synaptic Neurosci. 2021 Apr 8;13:660718. 

Preuss UW, Huestis MA, Schneider M, Hermann D, Lutz B, Hasan A, Kambeitz J, Wong JWM, Hoch E (2021) Cannabis Use and Car Crashes: A Review. Front Psychiatry. 2021 May 28;12:643315. 

Ruiz de Azua I, Martin-Garcia E, Domingo-Rodriguez L, Aparisi Rey A, Pascual Cuadrado D, Islami L, Turunen P, Remmers F, Lutz B, Maldonado R (2021) Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons drives overconsumption of palatable food and obesity. Neuropsychopharmacology. 2021 Apr;46(5):982-991.

Schepler H, Wang XH, Neufurth M, Wang SF, Schröder HC, Müller WEG (2021) The therapeutic potential of inorganic polyphosphate: A versatile physiological polymer to control coronavirus disease (COVID-19). Theranostics 11: 6193-6213

Schuele LL, Glasmacher S, Gertsch J, Roggan MD, Transfeld JL, Bindila L, Lutz B, Kolbe CC, Bilkei-Gorzo A, Zimmer A, Leidmaa E (2021) Diacylglycerol lipase alpha in astrocytes is involved in maternal care and affective behaviors. Glia 69(2):377-391. doi: 10.1002/glia.23903.

Siebers M, Biedermann SV, Bindila L, Lutz B, Fuss J (2021) Exercise-induced euphoria and anxiolysis do not depend on endogenous opioids in humans. Psychoneuroendocrinology. 2021 Apr;126:105173.

Spohrs J, Ulrich M, Grön G, Prost M, Plener PL, Fegert JM, Bindila L, Abler B (2021) Fear extinction learning and anandamide: an fMRI study in healthy humans. Transl Psychiatry. 2021 Mar 15;11(1):161.

Tölke SA, Masetto T, Grimmler M, Bindila L, Schneider K (2021) Letter to the Editor regarding "Development of an antibody-free ID-LC MS method for the quantification of procalcitonin in human serum at sub-microgram per liter level using a peptide-based calibration". Anal Bioanal Chem. 2021 Aug;413(19):4917-4919.

Yu X, Gao Y, Frank M, Mandi A, Kurtaan T, Müller WEG, Kalscheuer R, Guo ZY, Zou K, Liu Z, Proksch P (2021) Induction of ambuic acid derivatives by the endophytic fungus Pestalotiopsis lespedezae through an OSMAC approach. Tetrahedron 79:131876

Publikationen 2020

Ariantari NP., Ancheeva E, Frank M, Stuhldreier F, Meier D, Gröner Y, Reimche I, Teusch N, Wesselborg S, Müller WEG, Kalscheuer R, Liu Z, Proksch P (2020) Didymellanosine, a new decahydrofluorene analogue, and ascolactone C from Didymella sp. IEA-3B.1, an endophyte of Terminalia catappa. RSC Adv 10:7232-7240

Bilbao A, Neuhofer D, Sepers M, Wie SP, Eisenhardt M, Hertle S, Lassalle O, Ramos-Uriarte A, Puente N, Lerner R, Thomazeau A, Grandes P, Lutz B, Manzoni OJ, Spanagel R (2020) Endocannabinoid LTD in accumbal D1 neurons mediates reward-seeking behavior. iScience, 23(3), 100951.

Collu R#, Post JM#, Scherma M, Giunti E, Fratta W, Lutz B, Fadda P, Bindila L (2020) Altered brain levels of arachidonic acid-derived inflammatory eicosanoids in a rodent model of anorexia nervosa. BBA. Mol Cell Biol Lipids 1865(4), 158578. (#equal contributions)

De Giacomo V, Ruehle S, Lutz B, Häring M, Remmers F (2020) Differential glutamatergic and GABAergic contributions to the tetrad effects of Δ9-tetrahydrocannabinol revealed by cell-type-specific reconstitution of the CB1 receptor. Neuropharmacology. 2020 Nov 15;179:108287. doi: 10.1016/j.neuropharm.2020.108287. Epub 2020 Aug 26. PMID: 32860777.

de Salas-Quiroga A, García-Rincón D, Gómez-Domínguez D, Valero M, Simón-Sánchez S, Paraíso-Luna J, Aguareles J, Pujadas M, Muguruza C, Callado LF, Lutz B, Guzmán M, de la Prida LM, Galve-Roperh I (2020) Long-term hippocampal interneuronopathy drives sex-dimorphic spatial memory impairment induced by prenatal THC exposure Neuropsychopharmacol 45(5), 877–886.

Domingo-Rodriguez L#, Ruiz de Azua I#, Dominguez E, Senabre E, Serra I, Kummer S, Navandar M, Baddenhausen S, Hofmann C, Andero R, Gerber S, Navarrete M, Dierssen M, Lutz B*, Martín-García E*, Maldonado R* (2020) A specific prelimbic-nucleus accumbens pathway controls resilience versus vulnerability to food addiction. Nature Commun 11(1), 782. (#equal contributions; *shared senior authorships)

Gao Y, Stuhldreier F, Schmitt L, Wesselborg S, Wang L, Müller WEG, Kalscheuer R, Guo Z, Zou K, Liu Z, Proksch P (2020) Sesterterpenes and macrolide derivatives from the endophytic fungus Aplosporella javeedii. Fitoterapia 146:104652

Harwoko H, Lee J, Hartmann R, Mándi A, Kurtán T, Müller WEG, Feldbrügge M, Kalscheuer R, Ancheeva E, Daletos G, Frank M, Liu Z, Proksch P (2020) Azacoccones F-H, new flavipin-derived alkaloids from an endophytic fungus Epicoccum nigrum MK214079. Fitoterapia 146:104698 

Hedrich J, Angamo EA, Conrad A, Lutz B, Luhmann HJ (2020) Cell type specific impact of cannabinoid receptor signaling in somatosensory barrel map formation in mice. J Comp Neurol 528(1), 3–13.

Hellwig M, Merk DJ, Lutz B, Schüller U (2020) Preferential sensitivity to HDAC inhibitors in tumors with CREBBP mutation. Cancer Gene Ther 27(5), 294–300.

Herzog, DP, Mellema, RM, Remmers, F, Lutz, B, Müller, MB, Treccani, G (2020) Sexually dimorphic behavioral profile in a transgenic model enabling targeted recombination in active neurons in response to ketamine and (2R,6R)-hydroxynorketamine administration. Int J Mol Sci 21(6), 2142.

Jakubovski E, Pisarenko A, Fremer C, Haas M, May M, Schumacher C, Schindler C, Häckl S, Aguirre Davila L, Koch A, Brunnauer A, Cimpianu CL, Lutz B, Bindila L, Müller-Vahl K (2020) The CANNA-TICS Study Protocol: A Randomized Multi-Center Double-Blind Placebo Controlled Trial to Demonstrate the Efficacy and Safety of Nabiximols in the Treatment of Adults With Chronic Tic Disorders. Front Psychiatry 11:575826. doi: 10.3389/fpsyt.2020.575826.

Jimenez-Blasco D, Busquets-Garcia A, Hebert-Chatelain E, et al., Lutz B., et al., Marsicano G (2020) Glucose metabolism links astroglial mitochondria to cannabinoid effects. Nature [published online ahead of print, 2020 Jul 8]. doi:10.1038/s41586-020-2470-y

Kosterhon M, Neufurth M, Neulen A, Schäfe L, Conrad J, Kantelhardt SR, Müller WEG, Ringel F (2020) Multicolor 3D printing of complex intracranial tumors in neurosurgery. J Vis Exp 155:e60471; doi:10.3791/60471

Lutz B. (2020) Neurobiology of cannabinoid receptor signaling. Dialogues Clin Neurosci 22(3):207-222. doi: 10.31887/DCNS.2020.22.3/blutz.

Markl JS, Müller WEG, Sereno D, Elkhooly TA, Kokkinopoulou M, Gardères J, Depoix F, Wiens M (2020) A synthetic biology approach for the fabrication offunctional (fluorescent magnetic) bioorganic–inorganic hybrid materials in sponge primmorphs. Biotechnol Bioengin 117:1789-1804

Meyer Zu Reckendorf S, Brand C, Pedro MT, Hegler J, Schilling CS, Lerner R, Bindila L, Antoniadis G, Knöll B (2020) Lipid metabolism adaptations are reduced in human compared to murine Schwann cells following injury. Nature Commun 11(1), 2123.

Miederer I, Wiegand V, Bausbacher N, Leukel P, Maus S, Hoffmann MA, Lutz B, Schreckenberger M (2020) Quantification of the Cannabinoid Type 1 Receptor Availability in the Mouse Brain. Front Neuroanat 14:593793. doi: 10.3389/fnana.2020.593793.

Müller WEG, Ackermann M, Al-Nawas B, Righesso LAR, Muñoz-Espí R, Tolba E, Neufurth M, Schröder HC, Wang XH (2020) Amplified morphogenetic and bone forming activity of amorphous versus crystalline calcium phosphate/polyphosphate. Acta Biomater 118:233-247

Müller WEG, Neufurth M, Schepler H, Wang S, Tolba E, Schröder HC, Wang XH (2020) The biomaterial polyphosphate blocks stoichiometrically binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor. Biomater Sci 8: 6603–6610

Müller WEG, Neufurth M, Wang SF, Tan RW, Schröder HC, Wang XH (2020) Morphogenetic (mucin expression) as well as potential anti-corona viral activity of the marine secondary metabolite polyphosphate on A549 cells. Mar Drugs 18:639

Müller WEG, Schepler H, Tolba E, Wang SF, Ackermann M, Muñoz-Espí R, Xiao S, Tan RW, She ZD, Neufurth M, Schröder HC, Wang XH (2020) A physiologically active interpenetrating collagen network that supports growth and migration of epidermal keratinocytes: zinc-polyP nanoparticles integrated into compressed collagen. J Mater Chem B 8:5892-5902

Müller WEG, Tolba E, Wang S, Neufurth M, Lieberwirth I, Ackermann M, Schröder HC, Wang XH (2020) Nanoparticle-directed and ionically forced polyphosphate coacervation: A versatile and reversible core-shell system for drug delivery. Sci Rep 10:17147

Müller-Vahl KR, Bindila L, Lutz B, Musshoff F, Skripuletz T, Baumgaertel C, Sühs K W (2020) Cerebrospinal fluid endocannabinoid levels in Gilles de la Tourette syndrome. Neuropsychopharmacol 45(8), 1323–1329.

Neufurth M, Wang XH, Tolba E, Lieberwirth I, Wang S, Schröder HC, Müller WEG (2020) The inorganic polymer, polyphosphate, blocks binding of SARS-CoV-2 spike protein to ACE2 receptor at physiological concentrations. Biochem Pharmacol 182:114215

Pan F, El-Kashef DH, Kalscheuer R, Müller WEG, Lee J, Feldbrügge M, Mándi A, Kurtá T, Liu Z, Wu W, Proksch P (2020) Cladosins L-O, new hybrid polyketides from the endophytic fungus Cladosporium sphaerospermum WBS017. Eur J Med Chem 191:112159

Schröder HC, Wang XH, Müller WEG (2020) Biomimetic routes to micro/nanofabrication: Morphogenetically active high-energy inorganic polyphosphate nano/microparticles. In: Advances in Nanostructured Materials and Nanopatterning Technologies (ed. by Guarino V, Focarete ML, Pisignano D). Elsevier, São Paulo, pp 83-113

Tarragon E*, Bindila L*, Zimmer P, Lutz B, Meyer J (2020) Salivary endocannabinoids as mediators in the relationship between omega-6 and omega-3 fatty acid ratio intake from highly-processed foods and anthropometric markers of health in women. Int J Food Sci Nutr 71(2), 235–241. (*shared senior authorships)

Tolba E, Wang SF, Wang XH, Neufurth M, Ackermann M, Muñoz-Espí R, El-Hady BMA, Schröder HC, Müller WEG (2020) Self-healing properties of bioinspired amorphous CaCO3/polyphosphate-supplemented cement. Molecules 25:2360

Tolba E, Wang XH, Wang SF, Neufurth M, Ackermann M, Schröder HC, Müller WEG (2020) Amorphous polyphosphate and Ca-carbonate nanoparticles improve the self-healing properties of both technical and medical cements. Biotechnol J 15:2000101  

Wang SF, Wang XH, Neufurth M, Tolba E, Schepler H, Xiao SC, Schröder HC, Müller WEG (2020) Biomimetic alginate/gelatin cross-linked hydrogels supplemented with polyphosphate for wound healing applications. Molecules 25:5210

Yu X, Müller WEG, Meier D, Kalscheuer R, Guo Z, Zou K, Umeokoli BO, Liu Z, Proksch P (2020) Polyketide derivatives from mangrove derived endophytic fungus Pseudopestalotiopsis theae. Mar Drugs 18:129

Zibolka J, Wolf A, Rieger L, Rothgänger C, Jörns A, Lutz B, Zimmer A, Dehghani F, Bazwinsky-Wutschke I (2020) Influence of Cannabinoid Receptor Deficiency on Parameters Involved in Blood Glucose Regulation in Mice. Int J Mol Sci 21(9), 3168.

Publikationen 2019

Abdel-Wahab NM, Harwoko H, Müller WEG, Hamacher A, Kassack MU, Fouad MA, Kamel MS, Lin W, Ebrahim W, Liu Z, Proksch P (2019) Cyclic heptapeptides from the soil-derived fungus Clonostachys rosea. Bioorg Med Chem 27:3954-3959

Abdel-Wahab NM, Scharf S, Özkaya FC, Kurtán T, Mándi A, Fouad MA, Kamel MS, Müller WEG, Kalscheuer R, Lin W, Daletos G, Ebrahim W, Liu Z, Proksch P (2019) Induction of secondary metabolites from the marine-derived fungus Aspergillus versicolor through co-cultivation with Bacillus subtilis. Planta Med 85:503-512

Ackermann M, Tolba E, Neufurth M, Wang S, Schröder HC, Wang XH, Müller WEG (2019) Biomimetic transformation of polyphosphate microparticles during restoration of damaged teeth. Dental Mat 35:244-256

Aparisi Rey A, Karaulanov E, Sharopov S, Arab K, Schäfer A, Gierl M., Guggenhuber S., Brandes C., Pennella L, Gruhn WH, Jelinek R, Maul C, Conrad A, Kilb W, Luhmann HJ, Niehrs C*, Lutz B*(2019). Gadd45alpha modulates aversive learning through post-transcriptional regulation of memory-related mRNAs.  EMBO Rep 20(6), e46022. doi: 10.15252/embr.201846022 (*shared senior authorships)

Ariantari Ni P, Daletos G, Mándi A, Kurtán T, Müller WEG, Lin WH, Ancheeva E, Proksch P (2019) Expanding the chemical diversity of an endophytic fungus Bulgaria inquinans, an ascomycete associated with mistletoe, through OSMAC approach. RSC Adv 9:25119-25132

Ariantari NP, Ancheeva E, Wang C, Mándi A, Knedel TO, Kurtán T, Chaidir C, Müller WEG, Kassack MU, Janiak C, Daletos G, Proksch P (2019) Indole diterpenoids from an endophytic Penicillium sp. J Nat Prod 82:1412-1423

Bragado Alonso S, Reinert JK, Marichal N, Massalini S, Berninger B, Kuner T, Calegari F. (2019) An Increase in Neural Stem Cells and Olfactory Bulb Adult Neurogenesis Improves Discrimination of Highly Similar Odorants. EMBO J, 38:e98791.

Duerr GD, Heinemann JC, Kley J, Eichhorn L, Frede S, Weisheit C, Wehner S, Bindila L, Lutz B, Zimmer A, Dewald O (2019) Myocardial maladaptation to pressure overload in CB2 receptor-deficient mice. J Mol Cell Cardiol, 133, 86-98. doi: 10.1016/j.yjmcc.2019.06.003.

Ebada SS, El-Kashef DH, Müller WEG, Proksch P (2019) Cytotoxic eudesmane sesquiterpenes from Crepis sancta. Phytochem Lett 33:46-48

Ebada SS, Müller WEG, Lin WH, Proksch P (2019) New acyclic cytotoxic jasplakinolide derivative from the marine sponge Jaspis splendens. Mar Drugs 2019, 17, 100; doi:10.3390/md17020100.

Frank M, Hartmann R, Plenker M, Mándi A, Kurtán T, Özkaya FC, Müller WEG, Kassack MU, Hamacher A, Lin W, Liu Z, Proksch P (2019) Brominated azaphilones from the sponge-associated fungus Penicillium canescens strain 4.14.6a. J Nat Prod 82:2159-2166

Frank M, Özkaya FC, Müller WEG, Hamacher A, Kassack MU, Lin WH, Liu Z, Proksch P (2019) Cryptic secondary metabolites from the sponge-associated fungus Aspergillus ochraceus. Mar Drugs 17:99; doi:10.3390/md17020099

Gericke A, Wang XH, Ackermann M, Neufurth M, Wiens M, Schröder HC, Pfeiffer P, Müller WEG (2019) Utilization of metabolic energy in treatment of ocular surface disorders: Polyphosphate as an energy source for corneal epithelial cell proliferation. RSC Adv 9:22531-22539

Harwoko H, Daletos G, Stuhldreier F, Lee J, Wesselborg S, Feldbrügge M, Müller WEG, Kalscheuer R, Ancheeva E, Proksch P (2019) Dithiodiketopiperazine derivatives from endophytic fungi Trichoderma harzianum and Epicoccum nigrum. Nat Prod Res 18:1-9.

Hatt LP, Thompson K, Müller WEG, Stoddart MJ, Armiento AR (2019) Calcium polyphosphate manoparticles act as an effective inorganic phosphate source during osteogenic differentiation of human mesenchymal stem cells. Int J Mol Sci 20:5801; doi:10.3390/ijms20225801

Jehle J, Goerich H, Bindila L, Lutz B, Nickenig G, Tiyerili V (2019) Endocannabinoid 2-arachidonoylglycerol is elevated in the coronary circulation during acute coronary syndrome. PloS One 14(12), e0227142.

Kalamakis G, Brüne D, Ravichandran S, Bolz J, Fan W, Ziebell F, Stiehl T, Catalá-Martinez F, Kupke J, Zhao S, Llorens-Bobadilla E, Bauer K, Limpert S, Berger B, Christen U, Schmezer P, Mallm JP, Berninger B, Anders S, Del Sol A, Marciniak-Czochra A, Martin-Villalba A. (2019) Quiescence Modulates Stem Cell Maintenance and Regenerative Capacity in the Aging Brain. Cell, 176:1407-1419.e14.

Kang E, Song J, Lin Y, Park J, Lee JH, Hussani Q, Gu Y, Ge S, Li W, Hsu KS, Berninger B, Christian KM, Song H, Ming GL. (2019) Interplay between a Mental Disorder Risk Gene and Developmental Polarity Switch of GABA Action Leads to Excitation-Inhibition Imbalance. Cell Rep, 28:1419-1428.e3

Kirkedal C, Elfving B, Muller HK, Moreira FA, Bindila L, Lutz B, Wegener G, Liebenberg N (2019). Hemisphere-dependent endocannabinoid system activity in prefrontal cortex and hippocampus of the Flinders Sensitive Line rodent model of depression. Neurochem Int 125, 7-15.

Kranaster L, Hoyer C, Aksay S S, Bumb J M, Muller N, Zill P, Schwarz M J, Moll N, Lutz B, Bindila L, Zerr I, Schmitz M, Blennow K, Zetterberg H, Haffner D, Leifheit-Nestler M, Ozbalci C, Janke C, Thiel M, Sartorius A (2019). Biomarkers for antidepressant efficacy of electroconvulsive therapy: an exploratory cerebrospinal fluid study. Neuropsychobiol 77(1), 13-22.

Lerner R, Cuadrado DP, Post JM, Lutz B, Bindila L (2019) Broad lipidomic and transcriptional changes of prophylactic PEA administration in adult mice. Front Neurosci 13, 527. doi: 10.3389/fnins.2019.00527

Leschik J#, Eckenstaler R#, Endres T, Munsch T, Edelmann E, Richter K, Kobler O, Fischer KD, Zuschratter W, Brigadski T, Lutz B*, Lessmann V* (2019) Prominent Postsynaptic and Dendritic Exocytosis of Endogenous BDNF Vesicles in BDNF-GFP Knock-in Mice. Mol Neurobiol 56(10), 6833–6855. (#equal contributions; *shared senior authorships)

Liu S, Zhao Y, Heering C, Janiak C, Müller WEG, Akoné SH, Liu Z, Proksch P (2019) Sesquiterpenoids from the endophytic fungus Rhinocladiella similis. J Nat Prod 82: 1055-1062

Müller WEG, Schröder HC, Wang XH (2019) Inorganic polyphosphates as storage for and generator of metabolic energy in the extracellular matrix. Chem Rev 119:12337-12374

Müller WEG, Schröder HC, Wang XH (2019) The phosphoanhydride bond: one cornerstone of life. The Biochemist - Elements in Biochemistry 41: 22-27

Müller WEG, Tolba E, Wang S, Li Q, Neufurth M, Ackermann M, Muñoz-Espí R, Schröder HC, Wang XH (2019) Transformation of construction cement to a self-healing hybrid binder. Int J Molec Sci Mater Sci 20:2948; doi:10.3390/ijms20122948

Müller WEG, Wang SF, Ackermann M, Gerich T, Wiens M, Neufurth M, Schröder HC, Wang XH (2019) Biologization of allogeneic bone grafts with polyphosphate: A route to a biomimetic periosteum. Adv Funct Mater 29:1905220

Pérez-Brangulí F, Buchsbaum IY, Pozner T, Regensburger M, Fan W, Schray A, Börstler T, Mishra H, Gräf D, Kohl Z, Winkler J, Berninger B, Cappello S, Winner B. (2019) Human SPG11 Cerebral Organoids Reveal Cortical Neurogenesis Impairment. Hum Mol Genet, 28:961-971.

Rivera P, Silva-Peña D, Blanco E, Vargas A, Arrabal S, Serrano A, Pavón FJ, Bindila L, Lutz B, Rodríguez de Fonseca F, Suárez J (2019) Oleoylethanolamide restores alcohol-induced inhibition of neuronal proliferation and microglial activity in striatum. Neuropharmacol 146, 184–197.

Ruiz de Azua I, Lutz B (2019) Multiple endocannabinoid-mediated mechanisms in the regulation of energy homeostasis in brain and peripheral tissues. Cell Mol Life Sci 76(7), 1341-1363. doi: 10.1007/s00018-018-2994-6

Schoof M, Launspach M, Holdhof D, Nguyen L, Engel V, Filser S, Peters F, Immenschuh J, Hellwig M, Niesen J, Mall V, Ertl-Wagner B, Hagel C, Spohn M, Lutz B, Sedlacik J, Indenbirken D, Merk DJ, Schüller U (2019). The transcriptional coactivator and histone acetyltransferase CBP regulates neural precursor cell development and migration. Acta Neuropathol Commun 7(1), 199.

Schröder HC, Wang XH, Müller WEG (2019) Amorphous polyphosphate nanoparticles: Application of the morphogenetically active inorganic polymer for personalized tissue regeneration. J Phys D: Appl Phys 52:363001.

Suárez J, Rivera P, Aparisi Rey A, Pérez-Martín M, Arrabal S, Rodríguez de Fonseca F, Ruiz de Azua I*, Lutz B* (2019). Adipocyte cannabinoid CB1 receptor deficiency alleviates high fat diet-induced memory deficit, depressive-like behavior, neuroinflammation and impairment in adult neurogenesis. Psychoneuroendocrinol 110, 104418. (*shared senior authorship)

Tolba E, Wang XH, Ackermann M, Neufurth M, Muñoz-Espí R, Schröder HC, Müller WEG (2019) In situ polyphosphate nanoparticle formation in hybrid poly(vinyl alcohol)/karaya gum hydrogels: A porous scaffold inducing infiltration of mesenchymal stem cells. Adv Sci 6:1801452

Tran-Cong NM, Mandi A, Kurtan T, Müller WEG, Kalscheuer R, Lin W, Liu Z, Proksch P (2019) Induction of cryptic metabolites of the endophytic fungus Trichocladium sp. through OSMAC and co-cultivation. RSC Adv 9:27279-27288

Umeokoli BO, Ebrahim W, El-Neketi M, Müller WEG, Kalscheuer R, Lin W, Liu Z, Proksch P (2019) A new depsidone derivative from mangrove sediment derived fungus Lasiodiplodia theobromae. Nat Prod Res 33:2215-2222

Wang XH, Gericke A, Ackermann M, Wang S, Neufurth M, Schröder HC, Pfeiffer N, Müller WEG (2019) Polyphosphate, the physiological metabolic fuel for corneal cells: a potential biomaterial for ocular surface repair. Biomater Sci 7:5506-5515

Xiao Y, Xu D, Song H, Shu F, Wei P, Yang X, Zhong C, Wang XH, Müller WEG, Zheng YJ, Xiao S, Xia Z (2019) Cuprous oxide nanoparticles reduces hypertrophic scarring by inducing fibroblast apoptosis. Intern J Nanomed 14 5989-6000

Yu H, Höfert SP, Moussa M, Janiak, C, Müller WEG, Umeokoli BO, Dai H, Liu Z, Proksch P (2019) Polyketides and nitrogenous metabolites from the endophytic fungus Phomopsis sp. D15a2a. Tetrahydron Lett 60:1513125

Yu S, He R, Song A, Huang Y, Jin Z, Liang Y, Li Q, Wang XH, Müller WEG, Cao J (2019) Spatial and temporal dynamics of bacterioplankton community composition in a subtropical dammed karst river of southwestern China. Microbiol Open 2019: e849

Yu X, Müller WEG, Guo Z, Lin W, Zou K, Liu Z, Proksch P (2019) Indole alkaloids from the coprophilous fungus Aphanoascus fulvescens. Fitoterapia 136:104168

Zimmermann T#, Bartsch JC#, Beer A#, Lomazzo E, Guggenhuber S, Lange MD, Bindila L, Pape HC, Lutz B (2019) Impaired anandamide/palmitoylethanolamide signaling in hippocampal glutamatergic neurons alters synaptic plasticity, learning, and emotional responses. Neuropsychopharmacol 44(8), 1377-1388. doi: 10.1038/s41386-018-0274-7. (#equal contributions)

Publikationen 2018

Abdelwahab MF, Kurtán T, Mándi A, Müller WEG, Fouad MA, Kamel MS, Liu Z, Ebrahim W, Daletos G, Proksch P (2018) Induced secondary metabolites from the endophytic fungus Aspergillus versicolor through bacterial co-culture and OSMAC approaches. Tetrahedron Lett 59:2647-2652

Ackermann M, Wang XH, Wang SF, Neufurth M, Schröder HC, Isemer FE, Müller WEG (2018) Collagen-inducing biologization of prosthetic material for hernia repair: polypropylene meshes coated with polyP/collagen. J Biomed Mater Res Part B 106B:2109-2121

Bai J, Wang XH, Zhang CJ, Huang J, Müller WEG (2018) Lanthanum-containing bioparticles are associated with the influence of lanthanum on high phosphate mediated bone marrow stromal cells viability. Biometals 31:771-784

Bajic D, Monory K, Conrad A, Maul C, Schmid RM, Wotjak CT, Stein-Thoeringer CK (2018). Cannabinoid receptor type 1 in the brain regulates the affective component of visceral pain in mice. Neuroscience, 384, 397-405.

Baumeister D, Eich W, Lerner R, Lutz B, Bindila L, Tesarz J (2018). Plasma Parameters of the Endocannabinoid System Are Unaltered in Fibromyalgia. Psychotherapy and psychosomatics, 87(6), 377-379.

Carré GA, Siggers P, Xipolita M, Brindle P, Lutz B, Wells S, Greenfield A (2018) Loss of p300 and CBP disrupts histone acetylation at the mouse Sry promoter and XY gonadal sex reversal. Hum Mol Genet 27(1):190-198.

Deis S, Srivastava RK, Ruiz de Azua I, Bindila L, Baraghithy S, Lutz B, Bab I, Tam J (2018). Age-related regulation of bone formation by the sympathetic cannabinoid CB1 receptor. Bone 108: 34-42. doi:10.1016/j.bone.2017.12.018

Ebada SS, El-Neketic M, Ebrahim W, Mándid A, Kurtánd T, Kalscheuer R, Müller WEG, Proksch P (2018) Cytotoxic secondary metabolites from the endophytic fungus Aspergillus versicolor KU258497. Phytochem Lett 24:88-93

Ellwardt E, Pramanik G, Luchtman D, Novkovic T, Jubal ER, Vogt J, Arnoux I, Vogelaar CF, Mandal S, Schmalz M, Barger Z, de Azua IR, Kuhlmann T, Lutz B, Mittmann T, Bittner S, Zipp F & Stroh A (2018). Maladaptive cortical hyperactivity upon recovery from experimental autoimmune encephalomyelitis. Nature Neuroscience, 21(10), 1392-1403. doi:10.1038/s41593-018-0193-2

Gutierrez-Rodriguez A, Bonilla-Del Rio I, Puente N, Gomez-Urquijo SM, Fontaine CJ, Egana-Huguet J, Elezgarai I, Ruehle S, Lutz B, Robin LM, Soria-Gomez E, Bellocchio L, Padwal JD, van der Stelt M, Mendizabal-Zubiaga J, Reguero L, Ramos A, Gerrikagoitia I, Marsicano G, Grandes P (2018). Localization of the cannabinoid type-1 receptor in subcellular astrocyte compartments of mutant mouse hippocampus. Glia 66(7): 1417-1431. doi:10.1002/glia.23314

Hamed A, Schmitz R, Bergermann A, Totzke F, Kubbutat M, Müller WEG, Youssef DTA, Bishr MM, Kamel MS, Edrada-Ebel R, Wätjen W, Proksch P (2018) Bioactive pyrrole alkaloids isolated from the Red Sea: marine sponge Stylissa carteri. Z Naturforsch C 73:199-210

Heide EC, Bindila L, Post JM, Malzahn D, Lutz B, Nau R, Ribes S (2018). Prophylactic palmitoylethanolamide prolongs survival and decreases detrimental inflammation in aged mice with bacterial meningitis. Frontiers in Immunology, 9, 2671.

Jehle J, Schone B, Bagheri S, Avraamidou E, Danisch M, Frank I, Pfeifer P, Bindila L, Lutz B, Lutjohann D, Zimmer A, Nickenig G (2018). Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice. PLoS One 13(5): e0197751. doi:10.1371/journal.pone.0197751

Karow M, Camp JG, Falk S, Gerber T, Pataskar A, Gac-Santel M, Kageyama J, Brazovskaja A, Garding A, Fan W, Riedemann T, Casamassa A, Smiyakin A, Schichor C, Götz M, Tiwari VK, Treutlein B, Berninger B (2018). Direct pericyte-to-neuron reprogramming via unfolding of a neural stem cell-like program. Nat Neurosci, 21: 932-940.

Lerner R, Post JM, Ellis SR, Vos DRN, Heeren RMA, Lutz B, Bindila L. (2018) Simultaneous lipidomic and transcriptomic profiling in mouse brain punches of acute epileptic seizure model compared to controls. J Lipid Res, 59(2), 23-297.

Li Q, Liu C, Wang XH, Jin Z, Song A, Liang Y, Cao J, Müller WEG (2018) Influence of altered microbes on soil organic carbon availability in karst agricultural soils contaminated by Pb-Zn tailings. Front Microbiol 9:2062; doi: 10.3389/fmicb.2018.02062

Merk DJ, Ohli J, Merk ND, Thatikonda V, Morrissy S, Schoof M, Schmid SN, Harrison L, Filser S, Ahlfeld J, Erkek S, Raithatha K, Andreska T, Weißhaar M, Launspach M, Neumann JE, Shakarami M, Plenker D, Marra MA, Li Y, Mungall AJ, Moore RA, Ma Y, Jones SJM, Lutz B, Ertl-Wagner B, Rossi A, Wagener R, Siebert R, Jung A, Eberhart CG, Lach B, Sendtner M, Pfister SM, Taylor MD, Chavez L, Kool M, Schüller U (2018) Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma. Dev Cell 44(6):709-724.

Miederer I, Buchholz HG, Kronfeld A, Maus S, Weyer-Elberich V, Mildenberger P, Lutz B, Schreckenberger M. (2018) Pharmacokinetics of the cannabinoid receptor ligand [(18) F]MK-9470 in the rat brain - Evaluation of models using microPET. Med Phys, 45(2), 725-734.

Moffa M, Camposeo A, Fasano V, Fazio B, Iatì MA, Maragò OM, Saija R, Schröder HC, Müller WEG, Pisignano D (2018) Biomineral amorphous lasers through light-scattering surfaces assembled by electrospun fiber templates. Laser Photonics Rev 12: 1700224

Moreno E, Chiarlone A, Medrano M, Puigdellívol M, Bibic L, Howell L, Resel E, Puente N, Casarejos MJ, Perucho J, Botta J, Suelves N, Ciruela F, Ginés S, Galve-Roperh I, Casadó V, Grandes P, Lutz B, Monory K, Canela EI, Lluís C, McCormick PJ, Guzmán M (2018) Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum. Neuropsychopharmacology, 43(5), 964-977.

Müller WEG, Ackermann M, Wang SF, Neufurth M, Muñoz-Espí R, Feng QL, Schröder HC, Wang XH (2018) Inorganic polyphosphate induces accelerated tube formation of HUVEC endothelial cells. Cell Mol Life Sci 75:21-32

Müller WEG, Neufurth M, Wang S, Ackermann M, Muñoz-Espí R, Feng Q, Lu Q, Schröder HC, Wang XH (2018) Amorphous, smart, and bioinspired polyphosphate nano/microparticles: A biomaterial for regeneration and repair of osteo-articular impairments. Int J Mol Sci 19:427; doi:10.3390/ijms19020427

Müller WEG, Wang S, Tolba E, Neufurth M, Ackermann M, Muñoz-Espí R, Lieberwirth I, Glasser G, Schröder HC and Wang XH (2018) Transformation of amorphous polyphosphate nanoparticles into coacervate complexes: an approach for the encapsulation of mesenchymal stem cells. Small 14:e1801170. doi: 10.1002/smll.201801170

Müller WEG, Ackermann M, Tolba E, Neufurth M, Ivetac I, Kokkinopoulou M, Schröder HC, Wang XH (2018) Role of ATP during the initiation of microvascularization. Acceleration of an autocrine sensing mechanism facilitating chemotaxis by inorganic polyphosphate. Biochem J 475:3255-3273   

Naik RR, Sotnikov SV, Diepold RP, Iurato S, Markt PO, Bultmann A, Brehm N, Mattheus T, Lutz B, Erhardt A, Binder EB, Schmidt U, Holsboer F, Landgraf R, Czibere L (2018) Polymorphism in Tmem132d regulates expression and anxiety-related behavior through binding of RNA polymerase II complex. Transl Psychiatry 8(1):1.

Post JM, Loch S, Lerner R, Remmers F, Lomazzo E, Lutz B, Bindila L (2018). Antiepileptogenic effect of subchronic palmitoylethanolamide treatment in a mouse model of acute epilepsy. Front Mol Neurosci 11: 67. doi:10.3389/fnmol.2018.00067

Rinne P, Guillamat-Prats R, Rami M, Bindila L, Ring L, Lyytikäinen L-P, Raitoharju E, Oksala N, Lehtimäki T, Weber C, van der Vorst EPC, Steffens S (2018). Palmitoylethanolamide Promotes a Proresolving Macrophage Phenotype and Attenuates Atherosclerotic Plaque Formation. Arteriosclerosis, Thrombosis, and Vascular Biology, 38(11), 2562-2575.

Schneider M, Friemel CM, von Keller R, Adorjan K, Bonnet U, Hasan A, Hermann D, Kambeitz J, Koethe D, Kraus L, Leweke FM, Lutz B, Paul L, Pogarell O, Preuss U, Schäfer M, Schmieder S, Simon R, Storr M, Hoch E (2018). Cannabiskonsum zum Freizeitgebrauch. In E. Hoch, C. M. Friemel, & M. Schneider (Eds.), Cannabis: Potenzial und Risiko: Eine wissenschaftliche Bestandsaufnahme (pp. 65-264). Heidelberg: Springer-Verlag.

Schneider M, Hoch E, Simon R, Pfeiffer-Gerschel T, Kraus L, Häuser W, Lutz B (2018). Cannabis, Cannabinoide und das Endocannabinoidsystem. In E. Hoch, C. M. Friemel, & M. Schneider (Eds.), Cannabis: Potenzial und Risiko: Eine wissenschaftliche Bestandsaufnahme (pp. 1-36). Heidelberg: Springer-Verlag.

Tiwari N, Pataskar A, Péron S, Thakurela S, Sahu SK, Figueres-Oñate M, Marichal N, López-Mascaraque L, Tiwari VK, Berninger B. (2018) Stage-specific transcription factors drive astrogliogenesis by remodeling gene regulatory landscapes. Cell Stem Cell, 23:557-571

Tolba E, Wang XH, Ackermann M, Neufurth M, Muñoz-Espí R, Schröder HC, Müller WEG (2018) In-situ polyphosphate nanoparticle formation in hybrid poly(vinyl alcohol)/karaya gum-hydrogels: A porous scaffold inducing infiltration of mesenchymal stem cells. Adv Sci, in press

Umeokoli BO, Ebrahim W, El-Neketi M, Müller WEG, Kalscheuer R, Lin W, Liu Z, Proksch P (2018) A new depsidone derivative from mangrove sediment derived fungus Lasiodiplodia theobromae. Nat Prod Res 20:1-8  

Wang XH, Schröder HC, Müller WEG (2018) Amorphous polyphosphate, a smart bioinspired nano-/bio-material for bone and cartilage regeneration: Towards a new paradigm in tissue engineering. J Mat Chem B 6:2385-2412

Wickert M, Hildick KL, Baillie GL, Jelinek R, Aparisi Rey A, Monory K, Schneider M, Ross RA, Henley JM, Lutz B (2018). The F238L point mutation in the cannabinoid type 1 receptor enhances basal endocytosis via lipid rafts. Front Mol Neurosci 11: 230. doi:10.3389/fnmol.2018.00230

Zhao S, Fan W, Guo X, Xue L, Berninger B, Salierno MJ, Del Campo A (2018) Microenvironments to study migration and somal translocation in cortical neurons. Biomaterials,156: 238-247.

Zhu WH, Gao XJ, Zou XY, Müller WEG, Wang SF, Wang YG, Liu YH (2018) Biosilica porous microspheres promote the osteogenic/odontogenic differentiation of human dental pulp cells. J Biomat Tissue Engin 8:258-266

Zimmermann T, Maroso M, Beer A, Baddenhausen S, Ludewig S, Fan W, Vennin C, Loch S, Berninger B, Hofmann C, Korte M, Soltesz I, Lutz B, Leschik J (2018). Neural stem cell lineage-specific cannabinoid type-1 receptor regulates neurogenesis and plasticity in the adult mouse hippocampus. Cerebral Cortex, doi: 10.1093/cercor/bhy258.

Publikationen 2017

Azim K, Angonin D, Marcy G, Pieropan F, Rivera A, Donega V, Cantù C, Williams G, Berninger B, Butt AM, Raineteau O (2017). Pharmacogenomic identification of small molecules for lineage specific manipulation of subventricular zone germinal activity. PLoS Biol 15(3):e2000698.

Bicker F, Vasic V, Horta G, Ortega F, Nolte H, Kavyanifar A, Keller S, Stankovic ND, Harter PN, Benedito R, Lutz B, Bäuerle T, Hartwig J, Baumgart J, Krüger M, Radyushkin K, Alberi L, Berninger B, Schmidt MHH (2017) Neurovascular EGFL7 regulates adult neurogenesis in the subventricular zone and thereby affects olfactory perception. Nat Commun 8:15922.

Buchholz HG, Uebbing K, Maus S, Pektor S, Afahaene N, Weyer-Elberich V, Lutz B, Schreckenberger M, Miederer I (2017) Whole-body biodistribution of the cannabinoid type 1 receptor ligand [18F]MK-9470 in the rat. Nucl Med Biol 52:63-69.

Chicca A, Nicolussi S, Bartholomäus R, Blunder M, Aparisi Rey A, Petrucci V, Reynoso-Moreno IDC, Viveros-Paredes JM, Dalghi Gens M, Lutz B, Schiöth HB, Soeberdt M, Abels C, Charles RP, Altmann KH, Gertsch J (2017) Chemical probes to potently and selectively inhibit endocannabinoid cellular reuptake. Proc Natl Acad Sci U S A 114(25):E5006-E5015.

Dehorter N, Marichal N, Marín O, Berninger B (2017). Tuning neural circuits by turning the interneuron knob. Current Opinion in Neurobiology, 42: 144-151

Deis S, Srivastava RK, Ruiz de Azua I, Bindila L, Baraghithy S, Lutz B, Bab I, Tam J (2017) Age-related regulation of bone formation by the sympathetic cannabinoid CB1 receptor. Bone 108:34-42.

Ebada SS, Talaat AN, Labib RM, Mandi A, Kurtan T, Müller WEG, Singab AN, Proksch P (2017) Cytotoxic labdane diterpenes and bisflavonoid atropisomers from leaves of Araucaria bidwillii. Tetrahedron 73:3048-3055

Ebada SS, de Voogd N, Kalscheuer R, Müller WEG, Chaidire C, Proksch P (2017) Cytotoxic drimane meroterpenoids from the Indonesian marine sponge Dactylospongia elegans. Phytochem Lett 22:154-158

Elnaggar MS, Ebrahim W, Mandi A, Kurtan T, Müller WEG, Kalscheuer R, Singab A, Lin W, Liu Z, Proksch P (2017) Hydroquinone derivatives from the marine-derived fungus Gliomastix sp. RSC Adv 7:30640-30649

Farrukh A, Ortega F, Fan W, Marichal N, Paez JI, Berninger B, Campo AD, Salierno MJ (2017) Bifunctional Hydrogels Containing the Laminin Motif IKVAV Promote Neurogenesis. Stem Cell Reports, 9: 1432-1440

Farrukh A, Paez JI, Salierno M, Fan W, Berninger B, Del Campo A (2017) Bifunctional Poly(acrylamide) Hydrogels through Orthogonal Coupling Chemistries. Biomacromolecules, 18 : 906-913.

Gutiérrez-Rodríguez A, Puente N, Elezgarai I, Ruehle S, Lutz B, Reguero L, Gerrikagoitia I, Marsicano G, Grandes P (2017) Anatomical characterization of the cannabinoid CB1 receptor in cell-type-specific mutant mouse rescue models. J Comp Neurol 525: 302-318  

Jochum KP, Schuessler JA, Wang XH, Stoll B, Weis U, Müller WEG, Haug GH, Andreae MO, Froelich PN (2017) Whole-ocean changes in silica and Ge/Si ratios during the last deglacial deduced from long-lived giant glass sponges. Geophys Res Lett 44:11555-11564

Kalisch R, Wessa M, Lutz, B (2017) DFG-Sonderforschungsbereich SFB1193 „Neurobiologie der Resilienz gegenüber stressinduzierter psychischer Dysfunktion: Mechanismen verstehen und Prävention fördern“. Neuroforum 23(2): 124-129.

Karakatsani A, Marichal N, Urban S, Kalamakis G, Ghanem A, Schick A, Zhang Y, Conzelmann KK, Rüegg MA, Berninger B, Ruiz de Almodovar C, Gascón S, Kröger S. (2017) Neuronal LRP4 regulates synapse formation in the developing CNS. Development, 144: 4604-4615.

Kranaster L, Hoyer C, Aksay SS, Bumb JM, Leweke FM, Janke C, Thiel M, Lutz B, Bindila L, Sartorius A (2017) Electroconvulsive therapy enhances endocannabinoids in the cerebrospinal fluid of patients with major depression: a preliminary prospective study. Eur Arch Psychiatry Clin Neurosci doi: 10.1007/s00406-017-0789-7. [Epub ahead of print]

Küppers L, Ebrahim W, El-Neketi M, Özkaya FC, Mándi A, Kurtán T, Orfali RS, Müller WEG, Hartmann R, Lin W, Song W, Liu Z, Proksch P (2017) Lactones from the sponge-derived fungus Talaromyces rugulosus. Mar Drugs 15:359; doi:10.3390/md15110359

Lange MD, Daldrup T, Remmers F, Szkudlarek HJ, Lesting J, Guggenhuber S, Ruehle S, Jüngling K, Seidenbecher T, Lutz B, Pape HC. (2017) Cannabinoid CB1 receptors in distinct circuits of the extended amygdala determine fear responsiveness to unpredictable threat. Mol Psychiatry 2016 Oct 4. doi: 10.1038/mp.2016.156. [Epub ahead of print]

Lerner R, Post J, Loch S, Lutz B, Bindila L (2017) Targeting brain and peripheral plasticity of the lipidome in acute kainic acid-induced epileptic seizures in mice via quantitative mass spectrometry. Biochim Biophys Acta 1862: 255-267

Li Q, Song A, Peng W, Jin Z, Müller WEG, Wang XH (2017) Contribution of aerobic anoxygenic phototrophic bacteria to total organic carbon pool in aquatic system of subtropical karst catchments, Southwest China: Evidence from hydrochemical and microbiological study. FEMS Microbiol Ecol 93:2017. doi: 10.1093/femsec/fix065

Lomazzo E, König F, Abassi L, Jelinek R, Lutz B (2017) Chronic stress leads to epigenetic dysregulation in the neuropeptide-Y and cannabinoid CB1 receptor genes in the mouse cingulate cortex. Neuropharmacology 113: 301-313

Miederer I, Uebbing K, Röhrich J, Maus S, Bausbacher N, Krauter K, Weyer-Elberich V, Lutz B, Schreckenberger M, Urban R (2017) Effects of tetrahydrocannabinol on glucose uptake in the rat brain. Neuropharmacology 117:273-281

Mokhlesi A, Hartmann R, Kurtán T, Weber H, Lin W, Chaidir C, Müller WEG, Daletos G, Proksch P (2017) New 2-methoxy acetylenic acids and pyrazole alkaloids from the marine sponge Cinachyrella sp. Mar Drugs 15:356; doi:10.3390/md15110356

Müller WEG, Wang XH, Schröder HC (2017) New target sites for treatment of osteoporosis. In: W.E.G. Müller, XH Wang, HC Schröder (eds.) Blue Biotechnology, Progress in Molecular and Subcellular Biology 55, DOI 10.1007/978-3-319-51284-6_6

Müller WEG, Tolba E, Ackermann M, Neufurth M, Wang S, Feng Q, Schröder HC, Wang XH (2017) Fabrication of amorphous strontium polyphosphate microparticles that induce mineralization of bone cells in vitro and in vivo. Acta Biomater 50:89-101

Müller WEG, Ackermann M, Neufurth M, Tolba E, Wang S, Feng Q, Schröder HC, Wang XH (2017) A novel biomimetic approach to repair enamel cracks/carious damages and to reseal dentinal tubules by amorphous polyphosphate. Polymers 9:120.

Müller WEG, Neufurth M, Tolba E, Ackermann M, Korzhev M, Wang S, Feng Q, Schröder HC, Wang XH (2017) Bifunctional dentifrice: amorphous polyphosphate a regeneratively active sealant with potent anti-Streptococcus mutans activity. Dental Mater 33:753-764

Müller WEG, Neufurth M, Ackermann M, Tolba E, Wang S, Feng Q, Schröder HC, Wang XH (2017) Fabrication of a new physiological macroporous hybrid biomaterial/bioscaffold material based on polyphosphate and collagen by freeze-extraction. J Mat Chem B 5:3823-3835

Müller WEG, Schröder HC, Wang XH (2017) The understanding of the Metazoan skeletal system, based on the initial discoveries with siliceous and calcareous sponges. Mar Drugs 15:172; doi:10.3390/md15060172

Müller WEG, Wang S, Neufurth M, Kokkinopoulou M, Feng Q, Schröder HC, Wang XH (2017) Polyphosphate as a donor of high-energy phosphate for the synthesis of ADP and ATP. J Cell Sci 130:2747-2756

Müller WEG, Relkovic D, Ackermann M, Wang S, Neufurth M, Paravic-Radicevic A, Ushijima H, Schröder HC, Wang XH (2017) Enhancement of wound healing in normal and diabetic mice by topical application of amorphous polyphosphate - Superior effect of the host-guest composite material composed of collagen (host) and polyphosphate (guest). Polymers 9:300; doi: 10.3390/polym9070300

Müller WEG, Wang SF, Ackermann M, Neufurth M, Steffen R, Mecja E, Muñoz-Espí R, Feng QL, Schröder HC, Wang XH (2017) Rebalancing β-amyloid-induced decrease of ATP level by amorphous nano/micro polyphosphate: Suppression of the neurotoxic effect of amyloid β-protein fragment 25-35. Int J Mol Sci 18:2154; doi:10.3390/ijms18102154

Müller WEG, Wang S, Wiens M, Neufurth M, Ackermann M, Relkovic D, Kokkinopoulou M, Feng Q, Schröder HC, Wang XH (2017) Uptake of polyphosphate microparticles in vitro (SaOS-2 and HUVEC cells) followed by an increase of the intracellular ATP pool size. PLoS ONE 12(12):e0188977

Nangmo PK, Akone SH, Tsamo AT, Zhen L, Müller WEG, Proksch P, Nkengfack AE (2017) Colletotrin: A sesquiterpene lactone from the endophytic fungus Colletotrichum gloeosporioides associated with Trichilia monadelpha. Z f Naturforsch B 72b:697-703

Neufurth M, Wang XH, Wang SF, Steffen R, Ackermann M, Haep ND, Schröder HC, Müller WEG (2017) 3D printing of hybrid (bio)materials for bone tissue engineering: Calcium-polyphosphate microparticles encapsulated by polycaprolactone. Acta Biomater 64:377-388

Pabst AM, Müller WEG, Ackermann M (2017) Three-dimensional scanning electron microscopy of maxillofacial biomaterials. Br J Oral Maxillofac Surg 55:736-739

Ramírez-López MT, Vázquez M, Lomazzo E, Hofmann C, Blanco RN, Alén F, Antón M, Decara J, Arco R, Orio L, Suárez J, Lutz B, Gómez de Heras R, Bindila L, Rodríguez de Fonseca F (2017) A moderate diet restriction during pregnancy alters the levels of endocannabinoids and endocannabinoid-related lipids in the hypothalamus, hippocampus and olfactory bulb of rat offspring in a sex-specific manner PLoS One 12(3):e0174307. doi: 10.1371/journal.pone.0174307. eCollection 2017.

Remmers F, Lange MD, Hamann M, Ruehle S, Pape HC, Lutz B (2017) Addressing sufficiency of the CB1 receptor for endocannabinoid-mediated functions through conditional genetic rescue in forebrain GABAergic neurons (2017) Brain Struct Funct. doi: 10.1007/s00429-017-1411-5. [Epub ahead of print]

Ruehle S, Wager-Miller J, Straiker A, Farnsworth J, Murphy MN, Loch S, Monory K, Mackie K, Lutz B (2017) Discovery and characterization of two novel CB1 receptor splice variants with modified N-termini in mouse. J Neurochem 142(4):521-533.

Ruiz de Azua I, Mancini G, Srivastava RK, Rey AA, Cardinal P, Tedesco L, Zingaretti CM, Sassmann A, Quarta C, Schwitter C, Conrad A, Wettschureck N, Vemuri VK, Makriyannis A, Hartwig J, Mendez-Lago M, Bindila L, Monory K, Giordano A, Cinti S, Marsicano G, Offermanns S, Nisoli E, Pagotto U, Cota D, Lutz B (2017) Adipocyte cannabinoid receptor CB1 regulates energy homeostasis and alternatively activated macrophages. J Clin Invest 127:4148-4162. 

Schreiner F, Ackermann M, Michalik M, Hucklenbruch-Rother E, Bilkei-Gorzo A, Racz I, Bindila L, Lutz B, Dötsch J, Zimmer A, Woelfle J (2017) Developmental programming of somatic growth, behavior and endocannabinoid metabolism by variation of early postnatal nutrition in a cross-fostering mouse model. PLoS One 12(8):e0182754.

Schröder HC, Tolba E, Diehl-Seifert B, Wang XH, Müller WEG (2017) Electrospinning of bioactive wound-healing nets. In: Müller WEG, Wang XH, Schröder HC (eds.) Blue Biotechnology, Progress in Molecular and Subcellular Biology 55: 259-290. 

Schröder HC, Wang XH, Müller WEG (2017) Polyphosphat-Nano/Mikropartikel -- Energiereiche anorganische Polymer-Partikel für innovative Anwendungen in der Medizin. GIT-Labor [Portal für Anwender in Wissenschaft und Industrie] 61:30-32  

Sereno D, Müller WEG, Bausen M, Elkhooly TA, Markl JS, Wiens M (2017) An evolutionary perspective on the role of mesencephalic astrocyte-derived neurotrophic factor (MANF): At the crossroads of poriferan innate immune and apoptotic pathways. Biochem Biophys Rep 11:161-173

Vogt J, Kirischuk S, Unichenko P, Schlüter L, Pelosi A, Endle H, Yang JW, Schmarowski N, Cheng J, Thalman C, Strauss U, Prokudin A, Bharati BS, Aoki J, Chun J, Lutz B, Luhmann HJ, Nitsch R (2017) Synaptic Phospholipid Signaling Modulates Axon Outgrowth via Glutamate-dependent Ca2+-mediated Molecular Pathways. Cereb Cortex 27(1):131-145.

Wang H, Umeokoli BO, Eze P, Heering C, Janiak C, Müller WEG, Orfali RS, Hartmann R, Dai H, Lin W, Liu Z, Proksch P (2017) Secondary metabolites of the lichen-associated fungus Apiospora montagnei. Tetrahedron Lett 58:1702-1705

Wang XH, Neufurth M, Tolba E, Wang S, Schröder HC, Müller WEG (2017) Biocalcite and carbonic acid activators. In: Müller WEG, Wang XH, Schröder HC (eds.) Blue Biotechnology, Progress in Molecular and Subcellular Biology 55: 221-257. 

Wang XH, Guo YW, Tolba E, Kokkinopoulou M, Wiens M, Schröder HC, Müller WEG (2017) Two-armed activation of bone mineral deposition by the flavones baicalin and baicalein, encapsulated in polyphosphate microparticles. Am J Chin Med 45:533-555 

Wang XH, Ackermann M, Neufurth M, Wang S, Schröder HC, Müller WEG (2017) Morphogenetically active barrier membrane for guided bone regeneration, based on amorphous polyphosphate. Mar Drugs 15:142; doi:10.3390/md15050142 

Wang XH, Ackermann M, Neufurth M, Wang SF, Li Q, Feng QL, Schröder HC, Müller WEG (2017) Restoration of impaired metabolic energy balance (ATP pool) and tube formation potential of endothelial cells under “high glucose”, diabetic conditions by the bioinorganic polymer polyphosphate. Polymers 9:575; doi:10.3390/polym9110575

Publikationen 2016

Wang XH, Schröder HC, Müller WEG (2016) Polyphosphate as a metabolic fuel in Metazoa: A foundational breakthrough invention for biomedical applications. Biotechnol J 11: 11-30

Müller WEG, Schröder HC, Tolba E, Neufurth M, Diehl-Seifert B, Wang XH (2016) Mineralization of bone-related SaOS-2 cells under physiological hypoxic conditions. FEBS J 283: 74-87

Tolba E, Müller WEG, El-Hady BMA, Neufurth M, Wurm F, Wang S, Schröder HC, Wang XH (2016) High biocompatibility and improved osteogenic potential of amorphous calcium carbonate/vaterite. J Mat Chem B 4: 376-386

Müller WEG, Tolba E, Schröder HC, Muñoz-Espí R, Diehl-Seifert B, Wang XH (2016) Amorphous polyphosphate-hydroxyapatite: a morphogenetically active substrate for bone-related SaOS-2 cells in vitro. Acta Biomat 31: 358-367

Biedermann SV, Auer MK, Bindila L, Ende G, Lutz B, Weber-Fahr W, Gass P, Fuss J (2016) Restricted vs. unrestricted wheel running in mice: Effects on brain, behavior and endocannabinoids. Horm Behav 86: 45-54

Kleiderman S, Gutbier S, Tufekci KU, Ortega F, Sá JV, Teixeira AP, Brito C, Glaab E, Berninger B, Alves PM, Leist M (2016). Conversion of non-proliferating astrocytes into neurogenic neural stem cells: control by FGF2 and IFN-gamma. Stem Cells, 34: 2861-2874

Zimmermann T, Remmers F, Lutz B, Leschik J (2016) ESC-Derived BDNF-Overexpressing Neural Progenitors Differentially Promote Recovery in Huntington's Disease Models by Enhanced Striatal Differentiation. Stem Cell Reports 7: 693-706

Wang XH, Huang J, Wang K, Neufurth M, Schröder HC, Wang SF, Müller WEG (2016) The morphogenetically active polymer, inorganic polyphosphate complexed with GdCl3, as an inducer of hydroxyapatite formation in vitro. Biochem Pharmacol 102: 97-106

Daletos G, Liu Y, Kurtán T, Wang C, Lin WH, Orfali R, Müller WEG, Proksch P (2016) Cladosporinone, a new viriditoxin derivative from the hypersaline lake derived fungus Cladosporium cladosporioides. J Antibiotics 69: 702-706

Wang XH, Wang SF, He F, Tolba E, Schröder HC, Diehl-Seifert B, Müller WEG (2016) Polyphosphate a bioactive and biodegradable implant material: induction of bone regeneration in rats. Adv Engin Mater 18: 1406-1417

Mattheus T, Kukla K, Zimmermann T, Tenzer S, Lutz B (2016) Cell Type-Specific Tandem Affinity Purification of the Mouse Hippocampal CB1 Receptor-Associated Proteome. J Proteome Res 15: 3585-3601

Müller WEG, Neufurth M, Tolba E, Wang SF, Geurtsen W, Feng QL, Schröder HC, Wang XH (2016) A biomimetic approach to ameliorate dental hypersensitivity by amorphous polyphosphate microparticles. Dent Mater 32: 775-783

Müller WEG, Neufurth M, Wang SF, Tolba E, Schröder HC, Wang XH (2016) Morphogenetically active scaffold for osteochondral repair (polyphosphate/alginate/N,O- carboxymethyl chitosan. Eur Cell Mater 31: 174-190

Schröder HC, Grebenjuk VA, Wang XH, Müller WEG (2016) Hierarchical architecture of sponge spicules: Biocatalytic and structure-directing activity of silicatein proteins as model for bioinspired applications. Bioinspir Biomim 11: 041002

Schneider P, Bindila L, Schmahl C, Bohus M, Meyer-Lindenberg A, Lutz B, Spanagel R, Schneider M (2016) Adverse Social Experiences in Adolescent Rats Result in Enduring Effects on Social Competence, Pain Sensitivity and Endocannabinoid Signaling. Front Behav Neurosci 10:203

Schröder HC, Wang XH, Müller WEG (2016) Potenzial für Medizin und Nanotechnologie: Multitalentierte Biominerale. Biol Unserer Zeit 46: 158-168

Wang XH, Ackermann M, Wang SF, Tolba E, Neufurth M, Feng QL, Schröder HC, Müller WEG (2016) Amorphous polyphosphate/amorphous calcium carbonate implant material with enhanced bone healing efficacy in a critical-size defect in rats. Biomed Mater 11: 035005

Müller WEG, Ackermann M, Tolba E, Neufurth M, Wang SF, Schröder HC, Wang XH (2016) A bio-imitating approach to fabricate an artificial matrix for cartilage tissue engineering using magnesium-polyphosphate and hyaluronic acid. RSC Adv 6: 88559-88570

Heller M, Bauer HK, Goetze E, Gielisch M, Ozbolath I, Moncal KK, Rizk E, Seitz H, Gelinsky M, Schröder HC, Wang XH, Müller WEG, Al-Nawas B (2016) Materials and scaffolds in medical 3D printing and bioprinting in the context of bone regeneration. Int J Comput Dent 19: 301-321

Gentile A, Fresegna D, Musella A, Sepman H, Bullitta S, De Vito F, Fantozzi R, Usiello A, Maccarrone M, Mercuri NB, Lutz B, Mandolesi G, Centonze D (2016) Interaction between interleukin-1β and type-1 cannabinoid receptor is involved in anxiety-like behavior in experimental autoimmune encephalomyelitis. J Neuroinflammation 13: 231

McAvoy KM, Scobie KN, Berger S, Russo C, Guo N, Decharatanachart P, Ramirez H-V, Miake-Lye S, Whalen M, Nelson M, Bergami M, Bartsch D, Hen R, Berninger B, Sahay A (2016). Modulating neuronal competition dynamics in the dentate gyrus to rejuvenate aging memory circuits. Neuron 91: 1356-1373

Thakurela S, Tiwari N, Schick S, Garding A, Ivanek R, Berninger B, Tiwari VK (2016) Mapping gene regulatory circuitry of Pax6 during neurogenesis. Cell Discovery 2: 15045

Busquets-Garcia A, Gomis-González M, Srivastava RK, Cutando L, Ortega-Alvaro A, Ruehle S, Remmers F, Bindila L, Bellocchio L, Marsicano G, Lutz B, Maldonado R, Ozaita A (2016) Peripheral and central CB1 cannabinoid receptors control stress-induced impairment of memory consolidation. Proc Natl Acad Sci U S A 113: 9904-9

Heller M, Bauer HK, Goetze E, Gielisch M, Roth KE, Drees P, Maier GS, Dorweiler B, Ghazy A, Neufurth M, Müller WEG, Schröder HC, Wang XH, Vahl CF, Al-Nawas B (2016) Applications of patient-specific 3D printing in medicine. Int J Comput Dent 19: 323-339

Wang XH, Ackermann M, Tolba E, Neufurth M, Wurm F, Feng QL, Wang SF, Schröder HC, Müller WEG (2016) Artificial cartilage bio-matrix formed of hyaluronic acid and Mg2+-polyphosphate. Eur Cell Mater 32: 271-283

Müller WEG and Wang XH (2016) Evolution of the mineralized animal skeletons: Formation of bone hydroxyapatite via amorphous Ca-carbonate and Ca-phosphate. Eur Cells Mater 32 Suppl. 3: 1473

Müller WEG (2016) Schwämme und unsere Genetik. In: R. Schrott (Hrsg.) Erste Erde EPOS. Audiobook with MP3 Audio. Der Hörverlag, München. Artikel-Nr.: 9783446252820

Bindila L, Lutz B (2016) Extraction and Simultaneous Quantification of Endocannabinoids and Endocannabinoid-Like Lipids in Biological Tissues. Methods Mol Biol 1412: 9-18

Berninger B, Jessberger S (2016). Engineering of adult neurogenesis and gliogenesis. Cold Spring Harbor Perspectives in Biology, 8(5). pii: a018861

Sahu SK, Fritz A, Tiwari N, Kovacs Z, Pouya A, Wüllner V, Bora P, Schacht T, Baumgart J, Peron S, Berninger B, Tiwari VK, Methner A (2016) TOX3 regulates neural progenitor identity. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1859: 833-840

Feliszek M, Bindila L, Lutz B, Zimmer A, Bilkei-Gorzo A, Schlicker E (2016) Lack of hippocampal CB1 receptor desensitization by Δ(9)-tetrahydrocannabinol in aged mice and by low doses of JZL 184. Naunyn Schmiedebergs Arch Pharmacol 389: 603-12

Jenniches I, Ternes S, Albayram O, Otte DM, Bach K, Bindila L, Michel K, Lutz B, Bilkei-Gorzo A, Zimmer A (2016) Anxiety, Stress, and Fear Response in Mice With Reduced Endocannabinoid Levels. Biol Psychiatry 79: 858-68

Milano S, Schöne BR, Wang S, Müller WEG (2016) Impact of high pCO2 on shell structure of the bivalve Cerastoderma edule. Mar Environ Res 119: 144-155

Elnaggar MS, Ebada SS, Ashour ML, Ebrahim W, Müller WEG, Mándi A, Kurtán T, Singab A, Lin W, Liu Z, Proksch P (2016) Xanthones and sesquiterpene derivatives from a marine-derived fungus Scopulariopsis sp. Tetrahedron 72: 2411-2419

He W, Kienzle A, Liu XJ, Müller WEG, Elkhooly TA and Feng QL (2016) In vitro effect of 30 nm silver nanoparticles on adipogenic differentiation of human mesenchymal stem cells. J Biomedical Nanotechnol 12: 525-535

Guggenhuber S, Alpar A, Chen R, Schmitz N, Wickert M, Mattheus T, Harasta AE, Purrio M, Kaiser N, Elphick MR, Monory K, Kilb W, Luhmann HJ, Harkany T, Lutz B, Klugmann M (2015) Cannabinoid receptor-interacting protein Crip1a modulates CB1 receptor signaling in mouse hippocampus. Brain Struct Funct 221: 2061-74

Maroso M, Szabo GG, Kim HK, Alexander A, Bui AD, Lee SH, Lutz B, Soltesz I (2016) Cannabinoid Control of Learning and Memory through HCN Channels. Neuron 89: 1059-73

Bunk EC, Ertaylan G, Ortega F, Pavlou MA, Cano LG, Stergiopoulos A, Safaiyan S, Völs S, van Cann M, Politis PK, Simons M, Berninger B, del Sol A, Schwamborn JC (2016) Prox1 is required for oligodendrocyte cell identity in adult neural stem cells of the subventricular zone. Stem Cells 34: 2115-2129

Azim K, Berninger B, Raineteau (2016). Mosaic subventricular origins of forebrain oligodendrogenesis. Frontiers in Neuroscience, 10:107

Guggenhuber S, Romo-Parra H, Bindila L, Leschik J, Lomazzo E, Remmers F, Zimmermann T, Lerner R, Klugmann M, Pape HC, Lutz B (2016) Impaired 2-AG Signaling in Hippocampal Glutamatergic Neurons: Aggravation of Anxiety-Like Behavior and Unaltered Seizure Susceptibility. Int J Neuropsychopharmacol 19: 1-13

Seifert B, Eckenstaler R, Rönicke R, Leschik J, Lutz B, Reymann K, Lessmann V, Brigadski T (2016) Amyloid-Beta Induced Changes in Vesicular Transport of BDNF in Hippocampal Neurons. Neural Plast 2016: 4145708

He W, Liu XJ, Kienzle A, Müller WEG and Feng QL (2016) In vitro Uptake of silver nanoparticles and their toxicity in human mesenchymal stem cells derived from bone marrow. J Nanosc Nanotechnol 16: 219-228

Gardères J, Domart-Coulon I, Marie A, Hamer B, Batel R, Müller WEG and Bourguet-Kondracki ML (2016) Purification and partial characterization of a lectin protein complex, the clathrilectin, from the calcareous sponge Clathrina clathrus. Comp Biochem Physiol Part B 200: 17-27

Ramírez-López MT, Vázquez M, Bindila L, Lomazzo E, Hofmann C, Blanco RN, Alén, Antón M, Decara J, Ouro D, Orio L, Suarez J, Lutz B, Rodríguez de Fonseca F, Gómez de Heras R (2016) Exposure to a Highly Caloric Palatable Diet During Pregestational and Gestational Periods Affects Hypothalamic and Hippocampal Endocannabinoid Levels at Birth and Induces Adiposity and Anxiety-Like Behaviors in Male Rat Offspring. Front Behav Neurosci 9:339.

Gascón S, Mureno E, Masserdotti G, Ortega F, Russo GL, Petrik D, Deshpande A, Heinrich C, Karow M, Roberston SP, Schroeder T, Beckers J, Irmler M, Berndt C, Friedmann Angeli JP, Conrad M, Berninger B, Götz M (2016). Identification and successful negotiation of a metabolic checkpoint in direct neuronal reprogramming. Cell Stem Cell 18: 396-409Butenschön J, Zimmermann T, Schmarowski N, Nitsch R, Fackelmeier B, Friedemann K, Radyushkin K, Baumgart J, Lutz B, Leschik J (2016) PSA-NCAM positive neural progenitors stably expressing BDNF promote functional recovery in a mouse model of spinal cord injury. Stem Cell Res Ther 7:11.

Gardères J, Elkhooly TA, Link T, Markl JS, Müller WEG, Renkel J, Korzhev M and Wiens M (2016) Self-assembly and photocatalytic activity of branched silicatein/silintaphin filaments decorated with silicatein-synthesized TiO2 nanoparticles. Bioprocess Biosyst Eng 39: 1477-1486

Wang XH, Müller WEG (2016) Three-dimensional morphology and gene expression in animals. In: Encyclopedia of Molecular Cell Biology and Molecular Medicine. (Meyers RA, ed). WILEY-VCH Press, Weinheim, Vol 2/no 1:1-41; DOI: 10.1002/3527600906.mcb.200500041.pub2

Jehle J, Hoyer FF, Schöne B, Pfeifer P, Schild K, Jenniches I, Bindila L, Lutz B, Lütjohann D, Zimmer A, Nickenig G (2016) Myeloid-Specific Deletion of Diacylglycerol Lipase α Inhibits Atherogenesis in ApoE-Deficient Mice. PLoS One 11:e0146267.

Publikationen 2015

Hoegberg BG, Lomazzo E, Lee NH, Perry DC (2015) Regulation of α4β2α5 nicotinic acetylcholinergic receptors in rat cerebral cortex in early and late adolescence: Sex differences in response to chronic nicotine. Neuropharmacology 99:347-355.

Al Tarabeen M, Daletos G, Ebrahim W, Müller WEG, Hartmann R, Lin W and Proksch P (2015) Ircinal E, a new manzamine derivative from the Indonesian marine sponge Acanthostrongylophora ingens. Natural Prod Commun 10: 1952-1953

Kronfeld A, Buchholz HG, Maus S, Reuss S, Müller-Forell W, Lutz B, Schreckenberger M, Miederer I (2015) Evaluation of MRI and cannabinoid type 1 receptor PET templates constructed using DARTEL for spatial normalization of rat brains. Med Phys 42:6875.

Chen G, Wernig M, Berninger B, Nakafuku M, Parmar M, Zhang C-L (2015) In vivo reprogramming for brain and spinal cord repair. eNeuro, 2(5). pii: ENEURO.0106-15.2015

Lutz B, Marsicano G, Maldonado R, Hillard CJ (2015) The endocannabinoid system in guarding against fear, anxiety and stress. Nat Rev Neurosci 16:705-718.

He W, Kienzle A, Liu XJ, Müller WEG and Feng QL (2015) In vitro 30 nm silver nanoparticles promote chondrogenesis of human mesenchymal stem cells. RSC Adv 5: 49809–49818.

Uzor PF, Ebrahim W, Osadebe PO, Nwodo JN, Okoye FB, Müller WEG, Lin W, Liu Z and Proksch P (2015) Metabolites from Combretum dolichopetalum and its associated endophytic fungus Nigrospora oryzae - Evidence for a metabolic partnership. Fitoterapia 105: 147-150.

de Salas-Quiroga A, Díaz-Alonso J, García-Rincón D, Remmers F, Vega D, Gómez-Cañas M, Lutz B, Guzmán M, Galve-Roperh I (2015) Prenatal exposure to cannabinoids evokes long-lasting functional alterations by targeting CB1 receptors on developing cortical neurons. Proc Natl Acad Sci U S A 112: 13693-8

Wang XH, Schröder HC, Müller WEG (2015) Properties and applications of biosilica enzymatically synthesized by aquatic/marine sponges. In: Springer Handbook of Marine Biotechnology; Editor - Prof. Se-Kwon Kim. Heidelberg: Springer pp. 1265-1277

Li Qiang, Wang XH, Korzhev M, Schröder HC, Link T, Tahir MN, Diehl-Seifert B and Müller WEG (2015) Potential biological role of laccase from the sponge Suberites domuncula as an antibacterial defense component. Biochim Biophys – Gen Subj 1850: 118-128Fuss J, Steinle J, Bindila L, Auer MK, Kirchherr H, Lutz B, Gass P (2015) A runner's high depends on cannabinoid receptors in mice. Proc Natl Acad Sci USA 112:13105-8.

Péron S, Berninger B (2015) Previews: Imported stem cells strike against stroke. Cell Stem Cell 17: 501-502. Jokisch V, Kroll R, Lutz B, Bindila L, Schaffelder R, Schaible T (2015) Endocannabinoid levels in newborns in relation to the mode of delivery. Am J Perinatol 32:1145-50.

Han G, Müller WEG, Wang XH, Lilja L, Shen Z (2015) Porous titania surfaces on titanium with hierarchical macro- and mesoporosities for enhancing cell adhesion, proliferation and mineralization. Mater Sci Eng C Mater Biol Appl 47:376-383

Chen AL, Müller WEG, Hou XG, Xiao S (2015) New articulated protospongiid sponges from the early Cambrian Chengjiang biota. Palaeoworld 24:46–54

Müller WEG, Schröder HC, Feng QL, Schloßmacher U, Link T and Wang XH (2015) Development of a morphogenetically active scaffold for three-dimensional growth of bone cells: biosilica/alginate hydrogel for SaOS-2 Cell cultivation. J Tissue Engin Regen Med 9:E39-50.

Wang XH and Müller WEG (2015) Involvement of aquaporin channels in water extrusion from biosilica during maturation of sponge siliceous spicules. Biol. Bull. 229: 24–37. Blázquez C, Chiarlone A, Bellocchio L, Resel E, Pruunsild P, García-Rincón D, Sendtner M, Timmusk T, Lutz B, Galve-Roperh I, Guzmán M (2015) The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway. Cell Death Differ 22:1618-29.

Aravantinou-Fatorou K, Ortega F, Chroni-Tzartou D, Antoniou N, Poulopoulou C, Politis PK, Berninger B, Matsas R, Thomaidou D (2015) Cend1 and neurogenin2 reprogram mouse astrocytes and embryonic fibroblasts to induced neural precursors and differentiated neurons. Stem Cell Reports 5: 405-418

Duerr GD, Heinemann JC, Gestrich C, Heuft T, Klaas T, Keppel K, Roell W, Klein A, Zimmer A, Velten M, Kilic A, Bindila L, Lutz B, Dewald O (2015) Impaired border zone formation and adverse remodeling after reperfused myocardial infarction in cannabinoid CB2 receptor deficient mice. Life Sci 138:8-17.

Müller WEG, Tolba E, Schröder HC, Neufurth M, Wang S, Link T, Al-Nawas B and Wang XH (2015) A new printable and durable N,O-carboxymethyl chitosan-Ca2+-polyphosphate complex with morphogenetic activity. J. Mat. Chem B 3:1722-1730

Müller WEG, Tolba E, Schröder HC, Wang S, Glaßer G, Muñoz-Espí R, Link T, Wang XH (2015) A new polyphosphate calcium material with morphogenetic activity. Materials Letters 148:163-166 Müller WEG, Tolba E, Schröder HC, Neufurth M, Wang S, Link T, Al-Nawas B and Wang XH (2015) A new printable and durable N,O-carboxymethyl chitosan-Ca2+-polyphosphate complex with morphogenetic activity. J. Mat. Chem B 3:1722-1730

Müller WEG, Tolba E, Schröder HC, Wang S, Glaßer G, Muñoz-Espí R, Link T, Wang XH (2015) A new polyphosphate calcium material with morphogenetic activity. Materials Letters 148:163-166 Jenniches I, Ternes S, Albayram O, Otte DM, Bach K, Bindila L, Michel K, Lutz B, Bilkei-Gorzo A, Zimmer A (2015) Anxiety, stress, and fear response in mice with reduced endocannabinoid levels. Biol Psychiatry 79: 858-68.

Péron S, Berninger B (2015) Reawakening the Sleeping Beauty in the adult brain: neurogenesis from parenchymal glia. Current Opinion in Genetics & Development 34: 46-53

Legler A, Monory K, Lutz B (2015) Age differences in the role of the cannabinoid type 1 receptor on glutamatergic neurons in habituation and spatial memory acquisition. Life Sci 138:57-63.

Hammerschmidt L, Aly AH, Abdel-Aziz M, Müller WEG, Lin W, Daletos G and Proksch P (2015) Cytotoxic acyl amides from the soil fungus Gymnascella dankaliensis. Bioorg Med Chem 23:712-719.

Müller WEG, Tolba E, Schröder HC, Diehl-Seifert B and Wang XH (2015) Retinol encapsulated into amorphous Ca2+ polyphosphate nanospheres acts synergistically in MC3T3-E1 cells. Eur J Pharm Biopharm 93: 214-223

Njoo C, Agarwal N, Lutz B, Kuner R (2015) The Cannabinoid Receptor CB1 interacts with the WAVE1 complex and plays a role in actin dynamics and structural plasticity in neurons. PLoS Biol 13:e1002286.

Sahu SK, Garding A, Tiwari N, Thakurela S, Toedling J, Gebhard S, Ortega F, Schmarowski N, Berninger B, Nitsch R, Schmidt M, Tiwari VK (2015) JNK-dependent gene regulatory circuitry governs mesenchymal fate. The EMBO Journal 34: 2162-2181 Häring M, Enk V, Aparisi Rey A, Loch S, Ruiz de Azua I, Weber T, Bartsch D, Monory K, Lutz B (2015) Cannabinoid type-1 receptor signaling in central serotonergic neurons regulates anxiety-like behavior and sociability. Front Behav Neurosci 9:235.

Wang XH, Schröder HC, Müller WEG (2015) Properties and applications of biosilica enzymatically synthesized by aquatic/marine sponges. In: Kim SK (ed.) Functional Marine Biomaterials. Woodhead Publishing Series in Biomaterials. Elsevier: Amsterdam Pp. 33-50.

Wang XH and Müller W.E.G. (2015) Molecular morphogenesis: gene expression patterns in animals. In: Meyers RA (Ed) Encyclopedia of Molecular Cell Biology and Molecular Medicine: Developmental Biology. Wiley-VCH Verlag: Weinheim; in press.

Müller WEG, Tolba E, Schröder HC and Wang XH (2015) Polyphosphate: a morphogenetically active implant material serving as metabolic fuel for bone regeneration. Macromolec Biosci 15:1182-1197.

Hammerschmidt L, Ola A, Müller WEG, Lin WH, Mándi A, Kurtán T, Proksch P and Aly AH (2015) Two new metabolites from the endophytic fungus Xylaria sp. Isolated from the medicinal plant Curcuma xanthorrhiza. Tetrahedron Letters 56:1193–1197. Piyanova A, Lomazzo E, Bindila L, Lerner R, Albayram O, Ruhl T, Lutz B, Zimmer A, Bilkei-Gorzo A (2015) Age-related changes in the endocannabinoid system in the mouse hippocampus. Mech Ageing Dev 150: 55-64.

Masserdotti G, Gillotin S, Sutor B, Drechsel D, Irmler M, Jørgensen HF, Sass S, Theis FJ, Beckers J, Berninger B, Guillemot F, Götz M (2015) Transcriptional mechanisms of proneural factors and REST in regulating neuronal reprogramming of astrocytes. Cell Stem Cell 17: 74-88 Rivera P, Blanco E, Bindila L, Alen F, Vargas A, Rubio L, Pavón FJ, Serrano A, Lutz B, Rodríguez de Fonseca F, Suárez J (2015) Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the adult rat brain. Front Cell Neurosci 9:379.

Müller WEG, Neufurth M, Huang J, Wang K, Feng Q, Schröder HC, Diehl-Seifert B, Muñoz-Espí R, Wang XH (2015) Non-enzymatic transformation of amorphous CaCO3 into calcium phosphate mineral after exposure to sodium phosphate in vitro: Implications for in vivo hydroxyapatite bone formation. ChemBioChem 16:1323-1332.

Müller WEG, Tolba E, Feng Q, Schröder HC, Markl JS, Kokkinopoulou M and Wang XH (2015) Amorphous Ca2+ polyphosphate nanoparticles regulate the ATP level in bone-like SaOS-2 cells. J Cell Sci 128: 2202-2207.

Liu Y, Marmann A, Abdel-Aziz MS, Wang CY, Müller WEG, Lin WH, Mándi A, Kurtán T, Daletos G and Proksch P (2015) Tetrahydroanthraquinone derivatives from the endophytic fungus Stemphylium globuliferum. Eur J Org Chem 2015: 2646-2653

Schneider M, Kasanetz F, Lynch DL, Friemel CM, Lassalle O, Hurst DP, Steindel F, Monory K, Schäfer C, Miederer I, Leweke FM, Schreckenberger M, Lutz B, Reggio PH, Manzoni OJ, Spanagel R (2015) Enhanced functional activity of the cannabinoid type-1 receptor mediates adolescent behavior. J Neurosci 35:13975-88.

Raposo AASF, Vasconcelos FF, Drechsel D, Marie C, Johnston C, Dolle D, Bithell A, Gillotin S, van den Berg DLC, Ettwiller L, Flicek O, Crawfrod GE, Parras CM, Berninger B, Buckley NJ, Guillemot F, Castro DS (2015) Ascl1 coordinately regulates gene expression and the chromatin landscape during neurogenesis. Cell Reports 10: 1544-1556

Bergami M, Masserdotti G, Temprana SG, Motori E, Eriksson T, Göbel J, Yang SM, Conzelmann K-K, Schinder AF, Götz M, Berninger B (2015) A critical period of experience-dependent remodelling of adult-born neuron connectivity. Neuron 85: 710-717

Bilgin M, Bindila L, Graessler J, Shevchenko A (2015) Quantitative profiling of endocannabinoids in lipoproteins by LC-MS/MS. Anal Bioanal Chem 407:5125-31.

Neufurth M, Wang XH, Tolba E, Dorweiler B, Schröder HC, Link T, Diehl-Seifert B, Müller WEG (2015) Modular small diameter vascular grafts with bioactive functionalities. PLoS ONE; DOI:10.1371/journal.pone.0133632

Uzor PF, Ebrahim W, Osadebe PO, Nwodo JN, Okoye FB, Müller WEG, Lin W, Liu Z, Proksch P (2015) Metabolites from Combretum dolichopetalum and its associated endophytic fungus Nigrospora oryzae - Evidence for a metabolic partnership. Fitoterapia 105:147-150.

Müller WEG, Tolba E, Dorweiler B, Schröder HC, Diehl-Seifert B, Wang XH (2015) Electrospun bioactive mats enriched with Ca-polyphosphate/retinol nanospheres as potential wound dressing. Biochem Biophys Rep 3:150-160

Monory K, Polack M, Remus A, Lutz B, Korte M (2015) Cannabinoid CB1 receptor calibrates excitatory synaptic balance in the mouse hippocampus. J Neurosci 35:3842-50.

Heinrich C, Spagnoli FM, Berninger B (2015) In vivo reprogramming for tissue repair. Nature Cell Biology 17: 204-211

Rivera P, Bindila L, Pastor A, Pérez-Martín M, Pavón FJ, Serrano A, de la Torre R, Lutz B, Rodríguez de Fonseca F, Suárez J (2015) Pharmacological blockade of the fatty acid amide hydrolase (FAAH) alters neural proliferation, apoptosis and gliosis in the rat hippocampus, hypothalamus and striatum in a negative energy context. Front Cell Neurosci 9:98.

Gardères J, Bourguet-Kondracki ML, Hamer B, Batel R, Schröder HC., Müller WEG (2015) Porifera lectins: Diversity, physiological roles and biotechnological potential. Mar. Drugs, 13, 5059-5101.
Müller WEG, Tolba E, Schröder HC, Wang S, Glasser G, Diehl-Seifert B, Wang XH (2015) Biologizing titanium alloy implant material with morphogenetically active polyphosphate. RSC Advances 5: 75465–75473

Uzor PF, Ebrahim W, Osadebe PO, Nwodo JN, Okoye FB, Müller WEG, Lin W, Liu Z, Proksch P (2015) Metabolites from Combretum dolichopetalum and its associated endophytic fungus Nigrospora oryzae - Evidence for a metabolic partnership. Fitoterapia 105:147-150.

Gestrich C, Duerr GD, Heinemann JC, Meertz A, Probst C, Roell W, Schiller W, Zimmer A, Bindila L, Lutz B, Welz A, Dewald O (2015) Activation of Endocannabinoid System Is Associated with Persistent Inflammation in Human Aortic Aneurysm. Biomed Res Int 2015:456582.

Karow M, Berninger B (2015) In-TOX-icating neurogenesis. The EMBO Journal 34: 832-4. embj.201591107

Lomazzo E, Bindila L, Remmers F, Lerner R, Schwitter C, Hoheisel U, Lutz B (2015) Therapeutic potential of inhibitors of endocannabinoid degradation for the treatment of stress-related hyperalgesia in an animal model of chronic pain. Neuropsychopharmacology 40:488-501.

Li Q, Hu Q, Zhang C, Müller WEG., Schröder HC., Li Z, Zhang Y, Liu C, Jin Z (2015) The effect of toxicity of heavy metals contained in tailing sands on the organic carbon metabolic activity of soil microorganisms. from different land use types in the karst region. Environ Earth Sci 74:6747–6756

AlTarabeen M, Daletos G, Ebrahim W, Müller WEG, Hartmann R, Lin W and Proksch P (2015) Ircinal E, a new manzamine derivative from the Indonesian marine sponge Acanthostrongylophora ingens. Natural Prod Commun 10: 1952-1953

Publikationen 2014

Heinrich C, Bergami M, Gascón S, Lepier A, Viganò F, Dimou L, Sutor B, Berninger B, Götz M. (2014) Sox2-mediated conversion of NG2 glia into induced neurons in the injured adult cerebral Cortex. Stem Cell Reports 3(6): 1000-14. doi: 10.1016/j.stemcr.2014.10.007.

García-González D, Murcia-Belmonte V, Esteban PF, Ortega F, Díaz D, Sánchez-Vera I, Lebrón-Galán R, Escobar-Castañondo L, Martínez-Millán L, Weruaga E, García-Verdugo JM, Berninger B, de Castro F (2014).  Anosmin-1 over-expression increases adult neurogenesis in the subventricular zone and neuroblast migration to the olfactory bulb. Brain Structure and Function 2014 Oct 10. [Epub ahead of print]

Sakry D, Neitz A, Singh J, Frischknecht R, Marongiu D, Binamé F, Perera SS,Endres K, Lutz B, Radyushkin K, Trotter J, Mittmann T (2014) Oligodendrocyte Precursor Cells Modulate the Neuronal Network by Activity-Dependent Ectodomain Cleavage of Glial NG2. PLoS Biol 12(11):e1001993.

Chiarlone A, Bellocchio L, Blázquez C, Resel E, Soria-Gómez E, Cannich A, Ferrero JJ, Sagredo O, Benito C, Romero J, Sánchez-Prieto J, Lutz B, Fernández-Ruiz J, Galve-Roperh I, Guzmán M (2014) A restricted population of CB1 cannabinoid receptors with neuroprotective activity. Proc Natl Acad Sci USA 111:8257-62.

Daletos G, de Voogd NJ, Müller WEG, Wray V, Lin WH, Feger D, Kubbutat M, Aly AH, Proksch P (2014) Cytotoxic and protein kinase inhibiting Nakijiquinones and Nakijiquinols from the sponge Dactylospongia metachromia. J Nat Prod 77: 218–226.

Draenert FG, Hützen D, Neff A, Müller WEG (2014) Vertical bone augmentation procedures: Basics and techniques in dental implantology. J Biomed Mater Res Part A 102A:1605-1613.

Duerr GD, Heinemann JC, Suchan G, Kolobara E, Wenzel D, Geisen C, Matthey M, Passe-Tietjen K, Mahmud W, Ghanem A, Tiemann K, Alferink J, Burgdorf S, Buchalla R, Zimmer A, Lutz B, Welz A, Fleischmann BK, Dewald O (2014) The endocannabinoid-CB2 receptor axis protects the ischemic heart at the early stage of cardiomyopathy. Basic Res Cardiol 109:425.

Fang Z, Wang Y, Feng Q, Kienzle A, Müller WEG (2014) Hierarchical structure and cytocompatibility of fish scales from Carassius auratus. Mater Sci Engineer C 43: 145–152.

Finkenwirth C, Roßbach B, Schröder HC, Emser A, Muttray A (2014): In-vivo ozone exposure does not lead to an increase of single-strand-breaks in human peripheral lymphocytes. Hum Exp Toxicol 33: 517-521.

Gardères J, Henry J, Bernay B, Ritter A, Zatylny-Gaudin C, Wiens M, Müller WEG, LePennec G (2014) Cellular effects of bacterial N-3-oxo-dodecanoyl-L-homoserine lactone on the sponge Suberites domuncula (Olivi, 1792): insights into an intimate inter-kingdom dialogue. PLoS ONE 9: e97662. doi:10.1371/journal.pone.0097662

Gardères J, Wang XH, Müller WEG (2014) Molecular evolution of defense pathways in sponges: Self-self-recognition and fight against the non-self. In: Roitt I (Main Editor), Delves P (Editor-in-Chief) and Ratcliffe M, and Rolink A, Colona M, Guidos C, Martin A, Elliott T, Miyasaka M, Mosmann T, Clark E, Mantovani A, DeFranco T, Hein W, Kaye P, Biron C, Cooke A, Finn O, Cavazzana M. Encyclopedia of Immunobiology. Amsterdam: Elsevier; in press.

Hebert-Chatelain E, Reguero L, Puente N, Lutz B, Chaouloff F, Rossignol R, Piazza PV, Benard G, Grandes P, Marsicano G (2014) Cannabinoid control of brain bioenergetics: Exploring the subcellular localization of the CB1 receptor. Mol Metab 3:495-504.

Hebert-Chatelain E, Reguero L, Puente N, Lutz B, Chaouloff F, Rossignol R, Piazza PV, Benard G, Grandes P, Marsicano G (2014) Studying mitochondrial CB1 receptors: Yes we can. Mol Metab 3:339.

Hoyer FF, Khoury M, Slomka H, Kebschull M, Lerner R, Lutz B, Schott H, Lütjohann D, Wojtalla A, Becker A, Zimmer A, Nickenig G (2014) Inhibition of endocannabinoid-degrading enzyme fatty acid amide hydrolase increases atherosclerotic plaque vulnerability in mice. J Mol Cell Cardiol 66:126-32.

Jergas B, Schulte K, Bindila L, Lutz B, Schlicker E (2014) O-2050 facilitates noradrenaline release and increases the CB1 receptor inverse agonistic effect of rimonabant in the guinea pig hippocampus. Naunyn Schmiedebergs Arc Pharmacol 387:621-8.

Liu YS, Huang QL, Kienzle A, Müller WEG, Feng QL (2014) In vitro degradation of porous PLLA/pearl powder composite scaffolds. Mater Sci Engineer C 38: 227-234.

Müller WEG, Albert O, Schröder HC, Wang XH (2014) Bio-inorganic nanomaterials for biomedical applications (Bio-silica and Polyphosphate). In: Bhushan B, Luo D, Schricker S, Sigmund W, Zauscher S (eds) Handbook of Nanomaterials Properties. Berlin Heidelberg: Springer-Press; pp 389–408.

Müller WEG, Li Q, Schröder HC, Hönig N, Yuan DX, Grebenjuk VA, Mussino F, Giovine M, Wang XH (2014) Carbonic anhydrase: A key regulatory and detoxifying enzyme for Karst plants. Planta 239:213–229.

Müller WEG, Link T, Schröder HC, Korzhev M, Neufurth M, Brandt D, Wang XH (2014) Dissection of the structure-forming from the structure-guiding activity of silicatein: a biomimetic molecular approach to print optical fibers. J Mater Chem B, in press. DOI: 10.1039/C4TB00801D.

Müller WEG, Neufurth M, Schlossmacher U, Schröder HC, Pisignano D, Wang XH (2014) The sponge silicatein-interacting protein silintaphin-2 blocks calcite formation of calcareous sponge spicules at the vaterite stage. RSC Adv 4: 2577–2585.

Müller WEG, Schlossmacher U, Schröder HC, Lieberwirth I, Glasser G, Korzhev M, Neufurth M, Wang XH (2014) Enzyme-accelerated and structure-guided crystallization of Ca-carbonate: role of the carbonic anhydrase in the homologous system. Acta Biomater 10: 450–462.

Müller WEG, Schröder HC, Shen ZJ, Feng QL and Wang XH (2014) Inorganic polymers: Morphogenic inorganic biopolymers for rapid prototyping chain. In: Müller WEG, Wang XH and Schröder HC (eds) Biomedical Inorganic Polymers, Progress in Molecular and Subcellular Biology vol. 54; pp 235–259.

Müller WEG, Tolba E, Schröder HC, Diehl-Seifert B, Link T, Wang XH (2014) Biosilica-loaded poly(Ɛ-caprolactone) nanofibers mats provide a morphogenetically active surface scaffold for the growth and mineralization of the osteoclast-related SaOS-2 cells. Biotechnology J, DOI: 10.1002/biot.201400277.

Mueller WEG, Qiang L, Schroder HC., Honig N, Yuan D, Grebenjuk VA, Mussino F, Giovine M, Wang X Carbonic anhydrase: a key regulatory and detoxifying enzyme for Karst plants PLANTA. 2014; 239 (1): 213-229 Article

Mueller WEG, Neufurth M, Schlossmacher U, Schroeder HC., Pisignano D, Wang X The sponge silicatein-interacting protein silintaphin-2 blocks calcite formation of calcareous sponge spicules at the vaterite stage RSC ADVANCES. 2014; 4 (6): 2577-2585 Article

Müller WEG, Schröder HC, Wang XH, Albert O Bio-inorganic nanomaterials for biomedical applications (Bio-silica and Polyphosphate). Beitrag in: Handbook of Nanomaterials Properties, Springer 2014, S.20

Musella A, Sepman H, Mandolesi G, Gentile A, Fresegna D, Haji N, Conrad A, Lutz B, Maccarrone M, Centonze D (2014) Pre- and postsynaptic type-1 cannabinoid receptors control the alterations of glutamate transmission in experimental autoimmune encephalomyelitis. Neuropharmacology 79:567-72.

Neufurth M, Wang XH, Schröder HC, Feng QL, Diehl-Seifert B, Ziebart T, Steffen R, Wang SF, Müller WEG (2014) Engineering a morphogenetically active hydrogel for bioprinting of bioartificial tissue derived from human osteoblast-like SaOS-2 cells. Biomaterials; in press.

Pryce G, Visintin C, Ramagopalan SV, Al-Izki S, De Faveri LE, Nuamah RA, Mein CA, Montpetit A, Hardcastle AJ, Kooij G, de Vries HE, Amor S, Thomas SA, Ledent C, Marsicano G, Lutz B, Thompson AJ, Selwood DL, Giovannoni G, Baker D (2014) Control of spasticity in a multiple sclerosis model using central nervous system-excluded CB1 cannabinoid receptor agonists. FASEB J 28:117-30.

Ren DN, Albert O, Müller WEG, Feng QL (2014) Primary cell culture of fresh water Hyriopsis cumingii mantle/pearl sac tissues and its effect on calcium carbonate mineralization. Cryst Growth Des 14: 1149–1157.

Soria-Gómez E, Bellocchio L, Reguero L, Lepousez G, Martin C, Bendahmane M, Ruehle S, Remmers F, Desprez T, Matias I, Wiesner T, Cannich A, Nissant A, Wadleigh A, Pape HC, Chiarlone AP, Quarta C, Verrier D, Vincent P, Massa F, Lutz B, Guzmán M, Gurden H, Ferreira G, Lledo PM, Grandes P, Marsicano G (2014) The endocannabinoid system controls food intake via olfactory processes. Nat Neurosci 17:407-15.

Schröder HC, Wang XH, Schloßmacher U, Wiens M and Müller WEG (2014) Biogenic inorganic polysilicates (biosilica): Formation and biomedical applications. In: Müller WEG, Wang XH and Schröder HC (eds) Biomedical Inorganic Polymers, Progress in Molecular and Subcellular Biology vol. 54; pp 197–234.

Wang XH, Schröder HC, Grebenjuk V, Diehl-Seifert B, Mailänder V, Steffen R, Schloßmacher U, Müller WEG (2014) The marine sponge-derived inorganic polymers, biosilica and polyphosphate, as morphogenetically active matrices/scaffolds for differentiation of human multipotent stromal cells: Potential application in 3D printing and distraction osteogenesis. Mar Drugs 12:1131-1147.

Wang XH, Schröder HC, Feng Q, Diehl-Seifert B, Grebenjuk VA, Müller WEG (2014) Isoquercitrin and polyphosphate co-enhance mineralization of human osteoblast-like SaOS-2 cells via separate activation of two RUNX2 cofactors AFT6 and Ets1. Biochem Pharmacol 89:413–421.

Wang XH, Schröder HC, Müller WEG (2014) Biocalcite, a multifunctional inorganic polymer: Building block for calcareous sponge spicules and bioseed for the synthesis of calcium phosphate-based bone. Beilstein J Nanotechnol 5: 610–621.

Wang XH, Schröder HC, Müller WEG (2014) Enzyme-based biosilica and biocalcite: biomaterials for the future in regenerative medicine. Trends Biotechnol, doi: 10.1016/j.tibtech.2014.05.004.

Wang XH, Schröder HC, Müller WEG (2014) Enzymatically synthesized inorganic polymers as morphogenetically active bone scaffolds: application in regenerative medicine. Int Rev Cell Mol Biol, in press.

Wang XH, Schröder HC, Schloßmacher U, Müller WEG (2014) Inorganic polyphosphates: Biologically active biopolymers for biomedical applications. In: Müller WEG, Wang XH and Schröder HC (eds) Biomedical Inorganic Polymers, Progress in Molecular and Subcellular Biology vol. 54; pp 261–294.

Wang XH, Schröder HC, Schloßmacher U, Neufurth M, Feng Q, Diehl-Seifert B, Müller WEG (2014) Modulation of the initial mineralization process of SaOS-2 cells by carbonic anhydrase activators and polyphosphate. Calcif Tissue Int 94:495–509.

Wang S, Wang XH, Draenert FG, Albert O, Schröder HC, Mailänder V, Mitov G, Müller WEG (2014) Bioactive and biodegradable silica biomaterial for bone regeneration. Bone; in press.

Wiens M, Elkhooly TA, Schröder HC, Mohamed THA, Müller WEG (2014) Characterization and osteogenic activity of a silicatein/biosilicacoated chitosan-graft-polycaprolactone. Acta Biomater, DOI: 10.1016/j.actbio.2014.06.036.

Publikationen 2013

Adanyi N., Bori Z., Szendro I., Erdelyi K., Wang X., Schroeder H. C., Mueller W. E. G. Bacterial sensors based on biosilica immobilization for label-free OWLS detection NEW BIOTECHNOLOGY. 2013: 30 (5): 493-499 Article

Adanyi N., Bori Z., Szendro I., Erdelyi K., Wang X., Schroeder H. C., Mueller W. E. G. Biosilica-based immobilization strategy for label-free OWLS sensors SENSORS AND ACTUATORS B-CHEMICAL. 2013: 177: 1-+ Article

Bellocchio L., Soria-Gomez E., Quarta C., Metna-Laurent M., Cardinal P., Binder E., Cannich A., Delamarre A., Haering M., Martin-Fontecha M., Vega D., Leste-Lasserre T., Bartsch D., Monory K., Lutz B., Chaouloff F., Pagotto U., Guzman M., Cota D., Marsicano G. Activation of the sympathetic nervous system mediates hypophagic and anxiety-like effects of CB1 receptor Blockade PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013: 110 (12): 4786-4791 Article

Cong-Dat Pham ?, Hartmann Rudolf, Mueller Werner E. G., de Voogd Nicole, Lai Daowan, Proksch Peter Aaptamine Derivatives from the Indonesian Sponge Aaptos suberitoides JOURNAL OF NATURAL PRODUCTS. 2013: 76 (1): 103-106 Article

Dodd Garron T., Worth Amy A., Hodkinson Duncan J., Srivastava Raj K., Lutz Beat, Williams Steve R., Luckman Simon M. Central functional response to the novel peptide cannabinoid, hemopressin NEUROPHARMACOLOGY. 2013; 71: 27-36 Article

Duerr Georg D., Heinemann Jan C., Dunkel Silke, Zimmer Andreas, Lutz Beat, Lerner Raissa, Roell Wilhelm, Mellert Fritz, Probst Chris, Esmailzadeh Bahman, Welz Armin, Dewald Oliver Myocardial hypertrophy is associated with inflammation and activation of endocannabinoid system in patients with aortic valve Stenosis LIFE SCIENCES. 2013; 92 (20-21): 976-983 Article

El-Neketi Mona, Ebrahim Weaam, Ngoc Tu Duong ?, Gedara Sahar, Badria Farid, Saad Hassan-Elrady A., Mueller Werner E. G., Proksch Peter Cytotoxic Rocaglamide Derivatives from Aglaia duppereana ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES. 2013; 68 (7-8): 269-274 Article

Gaffal Evelyn, Cron Mira, Glodde Nicole, Bald Tobias, Kuner Rohini, Zimmer Andreas, Lutz Beat, Tueting Thomas Cannabinoid 1 Receptors in Keratinocytes Modulate Proinflammatory Chemokine Secretion and Attenuate Contact Allergic Inflammation JOURNAL OF IMMUNOLOGY. 2013; 190 (10): 4929-4936 Article

Haering M., Grieb M., Monory K., Lutz B., Moreira F. A. Cannabinoid CB1 receptor in the modulation of stress coping behavior in mice: The role of serotonin and different forebrain neuronal subpopulations NEUROPHARMACOLOGY. 2013; 65: 83-89 Article

Kasper Jennifer, Hermanns Maria I., Bantz Christoph, Koshkina Olga, Lang Thomas, Maskos Michael, Pohl Christine, Unger Ronald E., Kirkpatrick C. James Interactions of silica nanoparticles with lung epithelial cells and the association to flotillins
ARCHIVES OF TOXICOLOGY. 2013; 87 (6): 1053-1065 Article

Lai Daowan, Broetz-Oesterhelt Heike, Mueller Werner E. G., Wray Victor, Proksch Peter Bioactive polyketides and alkaloids from Penicillium citrinum, a fungal endophyte isolated from Ocimum tenuiflorum FITOTERAPIA. 2013; 91: 100-106 Article

Leschik Julia, Eckenstaler Robert, Nieweg Katja, Lichtenecker Petra, Brigadski Tanja, Gottmann Kurt, Lessmann Volkmar, Lutz Beat Embryonic stem cells stably expressing BDNF-GFP exhibit a BDNF-release-dependent enhancement of neuronal Differentiation JOURNAL OF CELL SCIENCE. 2013; 126 (21): 5062-5073 Article

Link Thorben, Wang Xiaohong, Schlossmacher Ute, Feng Qingling, Schroeder Heinz C., Mueller Werner E. G. An approach to a biomimetic bone scaffold: increased expression of BMP-2 and of osteoprotegerin in SaOS-2 cells grown onto silica-biologized 3D printed scaffolds RSC ADVANCES. 2013; 3 (28): 11140-11147 Article


Meuth P., Gaburro S., Lesting J., Legler A., Herty M., Budde T., Meuth S. G., Seidenbecher T., Lutz B., Pape H. -C. Standardizing the analysis of conditioned fear in rodents: a multidimensional software Approach GENES BRAIN AND BEHAVIOR. 2013; 12 (5): 583-592 Article

Miederer I., Maus S., Zwiener I., Podoprygorina G., Meshcheryakov D., Lutz B., Schreckenberger M. Evaluation of cannabinoid type 1 receptor expression in the rat brain using [F-18]MK-9470 microPET EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2013; 40 (11): 1739-1747 Article

Motori Elisa, Puyal Julien, Toni Nicolas, Ghanem Alexander, Angeloni Cristina, Malaguti Marco, Cantelli-Forti Giorgio, Berninger Benedikt, Conzelmann Karl-Klaus, Goetz Magdalena, Winklhofer Konstanze F., Hrelia Silvana, Bergami Matteo Inflammation-Induced Alteration of Astrocyte Mitochondrial Dynamics Requires Autophagy for Mitochondrial Network Maintenance CELL METABOLISM. 2013; 18 (6): 844-859 Article

Mueller Werner E. G., Schroeder Heinz C., Markl Julia S., Grebenjuk Vlad A., Korzhev Michael, Steffen Renate, Wang Xiaohong Cryptochrome in Sponges: A Key Molecule Linking Photoreception with Phototransduction JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY. 2013; 61 (11): 814-832 Article

Mueller Werner E. G. Genetic: cell biological-structural aspects of biomineralization: Sponge biosilica formation an exceptional model CYTOTECHNOLOGY. 2013; 65 (5): 680-680 Meeting Abstract

Mueller Werner E. G., Mugnaioli Enrico, Schroeder Heinz C., Schlossmacher Ute, Giovine Marco, Kolb Ute, Wang Xiaohong Hierarchical composition of the axial filament from spicules of the siliceous sponge Suberites domuncula: from biosilica-synthesizing nanofibrils to structure- and morphology-guiding triangular stems CELL AND TISSUE RESEARCH. 2013; 351 (1): 49-58 Article

Mueller Werner E. G., Schroeder Heinz C., Schlossmacher Ute, Grebenjuk Vlad A., Ushijima Hiroshi, Wang Xiaohong Induction of carbonic anhydrase in SaOS-2 cells, exposed to bicarbonate and consequences for calcium phosphate crystal Formation BIOMATERIALS. 2013; 34 (34): 8671-8680 Article

Mueller W. E. G., Wang X. H. Metazoan circadian rhythm: an universal "Zeitgeber" existing from sponges to humans INTEGRATIVE AND COMPARATIVE BIOLOGY. 2013; 53: E140-E140 Meeting Abstract

Mueller Werner E. G., Schroeder Heinz C., Pisignano Dario, Markl Julia S., Wang Xiaohong Metazoan Circadian Rhythm: Toward an Understanding of a Light-Based Zeitgeber in Sponges INTEGRATIVE AND COMPARATIVE BIOLOGY. 2013; 53 (1): 103-117 Article

Mueller Werner E. G., Wang Xiaohong, Proksch Peter, Perry Carole C., Osinga Ronald, Garderes Johan, Schroeder Heinz C. Principles of Biofouling Protection in Marine Sponges: A Model for the Design of Novel Biomimetic and Bio-inspired Coatings in the Marine Environment? MARINE BIOTECHNOLOGY. 2013; 15 (4): 375-398 Review

Mueller Werner E. G., Wang Xiaohong, Jochum Klaus Peter, Schroeder Heinz C.  Self-healing, an intrinsic property of biomineralization processes IUBMB LIFE. 2013; 65 (5): 382-396 Review

Mueller Werner E. G., Wang Xiaohong, Grebenjuk Vlad, Diehl-Seifert Baerbel, Steffen Renate, Schlossmacher Ute, Trautwein Anna, Neumann Sebastian, Schroeder Heinz C. Silica as a morphogenetically active inorganic polymer BIOMATERIALS SCIENCE. 2013; 1 (6): 669-678 Article

Mueller Werner E. G., Schroeder Heinz C., Burghard Zaklina, Pisignano Dario, Wang Xiaohong Silicateins-A Novel Paradigm in Bioinorganic Chemistry: Enzymatic Synthesis of Inorganic Polymeric Silica CHEMISTRY-A EUROPEAN JOURNAL. 2013; 19 (19): 5790-5804 Review

Mueller Werner E. G., Schroeder Heinz C., Muth Sandra, Gietzen Sabine, Korzhev Michael, Grebenjuk Vlad A., Wiens Matthias, Schlossmacher Ute, Wang Xiaohong The silicatein propeptide acts as inhibitor/modulator of self-organization during spicule axial filament Formation FEBS JOURNAL. 2013; 280 (7): 1693-1708 Article

Müller WEG, Wang XH, Schröder HC Biomedical Inorganic Polymers: Bioactivity and Applications of Natural and Synthetic Polymeric Inorganic Molecules Prog. Mol. Subcell. Biol.. 2013; 54: 1-303

Müller WEG, Schröder HC, Shen ZJ, Feng QL, Wang XH Inorganic polymers: Morphogenic inorganic biopolymers for rapid prototyping chain Prog. Mol. Subcell. Biol.. 2013; 54: 235-259

Müller WEG, Wang XH, Grebenjuk V, Diehl-Seifert B, Steffen R, Schloßmacher U, Trautwein A, Neumann S, Schröder HC Silica as a morphogenetically active inorganic polymer: effect on the BMP-2-dependent and RUNX2-independent pathway in osteoblast-like SaOS-2 cells Biomaterials Science. 2013; (6): 669-678

Müller WEG, Schröder HC, Schlossmacher U, Neufurth M, Geurtsen W, Korzhev M, Wang XH The enzyme carbonic anhydrase as an integral component of biogenic Ca-carbonate formation in sponge spicules FEBS Open Bio. 2013; (3): 357-362

Natalio Filipe, Corrales Tomas P., Panthoefer Martin, Schollmeyer Dieter, Lieberwirth Ingo, Mueller Werner E. G., Kappl Michael, Butt Hans-Juergen, Tremel Wolfgang Flexible Minerals: Self-Assembled Calcite Spicules with Extreme Bending Strength SCIENCE. 2013; 339 (6125): 1298-1302 Article

Niemann Hendrik, Lin Wenhan, Mueller Werner E. G., Kubbutat Michael, Lai Daowan, Proksch Peter Trimeric Hemibastadin Congener from the Marine Sponge Ianthella basta JOURNAL OF NATURAL PRODUCTS. 2013; 76 (1): 121-125 Article

Nosenko Tetyana, Schreiber Fabian, Adamska Maja, Adamski Marcin, Eitel Michael, Hammel Joerg, Maldonado Manuel, Mueller Werner E. G., Nickel Michael, Schierwater Bernd, Vacelet Jean, Wiens Matthias, Woerheide Gert Deep metazoan phylogeny: When different genes tell different stories MOLECULAR PHYLOGENETICS AND EVOLUTION. 2013; 67 (1): 223-233 Article


Ortega Felipe, Gascon Sergio, Masserdotti Giacomo, Deshpande Aditi, Simon Christiane, Fischer Judith, Dimou Leda, Lie D. Chichung, Schroeder Timm, Berninger Benedikt Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling NATURE CELL BIOLOGY. 2013; 15 (6): 602-+ Article

Ruehle Sabine, Remmers Floor, Romo-Parra Hector, Massa Federico, Wickert Melanie, Woertge Simone, Haering Martin, Kaiser Nadine, Marsicano Giovanni, Pape Hans-Christian, Lutz Beat Cannabinoid CB1 Receptor in Dorsal Telencephalic Glutamatergic Neurons: Distinctive Sufficiency for Hippocampus-Dependent and Amygdala-Dependent Synaptic and Behavioral Functions JOURNAL OF NEUROSCIENCE. 2013; 33 (25): 10264-10277 Article

Schlossmacher Ute, Schroeder Heinz C., Wang Xiaohong, Feng Qingling, Diehl-Seifert Baerbel, Neumann Sebastian, Trautwein Anna, Mueller Werner E. G. Alginate/silica composite hydrogel as a potential morphogenetically active scaffold for three-dimensional tissue Engineering RSC ADVANCES. 2013; 3 (28): 11185-11194 Article

Schröder HC, Wang XH, Schloßmacher U, Wiens M, Müller WEG Biogenic inorganic polysilicates (bio-silica): formation and biomedical applications Prog. Mol. Subcell. Biol.. 2013; 54: 197-234

Schroeder Heinz C. Silicatein interactors and structure-guided biosilica Formation CYTOTECHNOLOGY. 2013; 65 (5): 682-682 Meeting Abstract

Steindel Frauke, Lerner Raissa, Haering Martin, Ruehle Sabine, Marsicano Giovanni, Lutz Beat, Monory Krisztina Neuron-type specific cannabinoid-mediated G protein signalling in mouse hippocampus JOURNAL OF NEUROCHEMISTRY. 2013; 124 (6): 795-807 Article

Stumm Christoph, Hiebel Christof, Hanstein Regina, Purrio Martin, Nagel Heike, Conrad Andrea, Lutz Beat, Behl Christian, Clement Angela B. Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid Deposition NEUROBIOLOGY OF AGING. 2013; 34 (11): 2574-2584 Article

Tahir Muhammad Nawaz, Ali Mubarak, Andre Rute, Mueller Werner E. G., Schroeder Heinz-Christoph, Tremel Wolfgang, Ensinger Wolfgang Silicatein conjugation inside nanoconfined geometries through immobilized NTA-Ni(II) chelates
CHEMICAL COMMUNICATIONS. 2013; 49 (22): 2210-2212 Article

von Jonquieres Georg, Mersmann Nadine, Klugmann Claudia Bettina, Harasta Anne Editha, Lutz Beat, Teahan Orla, Housley Gary David, Frohlich Dominik, Kramer-Albers Eva-Maria, Klugmann Matthias Glial Promoter Selectivity following AAV-Delivery to the Immature Brain PLOS ONE. 2013; 8 (6):  Article 
Wang XH, Schloßmacher U, Schröder HC, Müller WEG A milestone in biomineralization: From a structural assessment to a genetic concept of mineral formation. Beitrag in: Progress in Silicones and Silicone-Modified Materials American Chemical Society 2013, S.157-176

Wang Xiaohong, Schlossmacher Ute, Schroeder Heinz C., Mueller Werner E. G. Biologically induced transition of bio-silica sol to mesoscopic gelatinous flocs: a biomimetic approach to a controlled fabrication of bio-silica structures SOFT MATTER. 2013; 9 (3): 654-664 Article

Wang Xiaohong, Schroeder Heinz C., Schlossmacher Ute, Jiang Lei, Korzhev Michael, Mueller Werner E. G. Biosilica aging: From enzyme-driven gelation via syneresis to chemical/biochemical hardening BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 2013; 1830 (6): 3437-3446 Article

Wang Xiaohong Bio-silica and bio-polyphosphate: applications in biomedicine (bone formation) CYTOTECHNOLOGY. 2013; 65 (5): 681-681 Meeting Abstract

Wang Xiaohong, Schroeder Heinz C., Diehl-Seifert Baerbel, Kropf Klaus, Schlossmacher Ute, Wiens Matthias, Mueller Werner E. G. Dual effect of inorganic polymeric phosphate/polyphosphate on osteoblasts and osteoclasts in vitro JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. 2013; 7 (10): 767-776 Article

Wang XH, Schröder HC, Schloßmacher U, Müller WEG Inorganic polyphosphates: biologically active biopolymers for biomedical applications Prog. Mol. Subcell. Biol.. 2013; 54: 261-294

Wang Xiaohong, Brandt David, Thakur Narsinh L., Wiens Matthias, Batel Renato, Schroeder Heinz C., Mueller Werner E. G. Molecular cross-talk between sponge host and associated microbes PHYTOCHEMISTRY REVIEWS. 2013; 12 (3): 369-390 Review 

Wang Xiaohong, Schroeder Heinz C., Feng Qingling, Draenert Florian, Mueller Werner E. G. The Deep-Sea Natural Products, Biogenic Polyphosphate (Bio-PolyP) and Biogenic Silica (Bio-Silica), as Biomimetic Scaffolds for Bone Tissue Engineering: Fabrication of a Morphogenetically-Active Polymer MARINE DRUGS. 2013; 11 (3): 718-746 Review 
Wang Xiaohong, Gan Lu, Schroeder Heinz C., Mueller Werner E. G. Paradigm Shift in Bioinorganic Chemistry: Enzymatic Polycondensation Reaction of Silica in Siliceous Sponges PROGRESS IN CHEMISTRY. 2013; 25 (4): 435-445 Article 
Wiens Matthias, Niem Thomas, Elkhooly Tarek A., Steffen Renate, Neumann Sebastian, Schlossmacher Ute, Mueller Werner E. G. Osteogenic potential of a biosilica-coated P(UDMA-co-MPS) copolymer JOURNAL OF MATERIALS CHEMISTRY B. 2013; 1 (27): 3339-3343 Article

Zhou Yaming, Debbab Abdessamad, Mandi Attila, Wray Victor, Schulz Barbara, Mueller Werner E. G., Kassack Matthias, Lin WenHan, Kurtan Tibor, Proksch Peter, Aly Amal H. Alkaloids from the Sponge-Associated Fungus Aspergillus sp. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2013; (5): 894-906 Article


Publikationen 2012

Bashashati M., Storr M. A., Nikas S. P., Wood J. T., Godlewski G., Liu J., Ho W., Keenan C. M., Zhang H., Alapafuja S. O., Cravatt B. F., Lutz B., Mackie K., Kunos G., Patel K. D., Makriyannis A., Davison J. S., Sharkey K. A.
Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice
BRITISH JOURNAL OF PHARMACOLOGY. 2012; 165 (5): 1556-1571 Article

Bauer Mark, Chicca Andrea, Tamborrini Marco, Eisen David, Lerner Raissa, Lutz Beat, Poetz Oliver, Pluschke Gerd, Gertsch Juerg
Identification and Quantification of a New Family of Peptide Endocannabinoids (Pepcans) Showing Negative Allosteric Modulation at CB1 Receptors
JOURNAL OF BIOLOGICAL CHEMISTRY. 2012; 287 (44): 36944-36967 Article

Benard Giovanni, Massa Federico, Puente Nagore, Lourenco Joana, Bellocchio Luigi, Soria-Gomez Edgar, Matias Isabel, Delamarre Anna, Metna-Laurent Mathilde, Cannich Astrid, Hebert-Chatelain Etienne, Mulle Christophe, Ortega-Gutierrez Silvia, Martin-Fontecha Mar, Klugmann Matthias, Guggenhuber Stephan, Lutz Beat, Gertsch Juerg, Chaouloff Francis, Lopez-Rodriguez Maria Luz, Grandes Pedro, Rossignol Rodrigue, Marsicano Giovanni
Mitochondrial CB1 receptors regulate neuronal energy metabolism
NATURE NEUROSCIENCE. 2012; 15 (4): 558-564 Article

Cardinal Pierre, Bellocchio Luigi, Clark Samantha, Cannich Astrid, Klugmann Matthias, Lutz Beat, Marsicano Giovanni, Cota Daniela
Hypothalamic CB1 Cannabinoid Receptors Regulate Energy Balance in Mice
ENDOCRINOLOGY. 2012; 153 (9): 4136-4143 Article

Conzelmann Annette, Reif Andreas, Jacob Christian, Weyers Peter, Lesch Klaus-Peter, Lutz Beat, Pauli Paul
A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional-motivational reactivity
PSYCHOPHARMACOLOGY. 2012; 224 (4): 573-579 Article

Diaz-Alonso Javier, Aguado Tania, Wu Chia-Shan, Palazuelos Javier, Hofmann Clementine, Garcez Patricia, Guillemot Francois, Lu Hui-Chen, Lutz Beat, Guzman Manuel, Galve-Roperh Ismael
The CB1 Cannabinoid Receptor Drives Corticospinal Motor Neuron Differentiation through the Ctip2/Satb2 Transcriptional Regulation Axis
JOURNAL OF NEUROSCIENCE. 2012; 32 (47): 16651-16665 Article

Dubreucq Sarah, Matias Isabelle, Cardinal Pierre, Haering Martin, Lutz Beat, Marsicano Giovanni, Chaouloff Francis
Genetic Dissection of the Role of Cannabinoid Type-1 Receptors in the Emotional Consequences of Repeated Social Stress in Mice
NEUROPSYCHOPHARMACOLOGY. 2012; 37 (8): 1885-1900 Article

El Amrani Mustapha, Debbab Abdessamad, Aly Amal H., Wray Victor, Dobretsov Sergey, Mueller Werner E. G., Lin Wenhan, Lai Daowan, Proksch Peter
Farinomalein derivatives from an unidentified endophytic fungus isolated from the mangrove plant Avicennia marina
TETRAHEDRON LETTERS. 2012; 53 (49): 6721-6724 Article

Fouad Mostafa A., Debbab Abdessamad, Wray Victor, Mueller Werner E. G., Proksch Peter
New bioactive alkaloids from the marine sponge Stylissa sp.
TETRAHEDRON. 2012; 68 (49): 10176-10179 Article

Grabiec Urszula, Koch Marco, Kallendrusch Sonja, Kraft Robert, Hill Kerstin, Merkwitz Claudia, Ghadban Chalid, Lutz Beat, Straiker Alex, Dehghani Faramarz
The endocannabinoid N-arachidonoyldopamine (NADA) exerts neuroprotective effects after excitotoxic neuronal damage via cannabinoid receptor 1 (CB1)
NEUROPHARMACOLOGY. 2012; 62 (4): 1797-1807 Article

Haering M., Guggenhuber S., Lutz B.
NEUROSCIENCE. 2012; 204: 145-158 Review

Hons I. M., Storr M. A., Mackie K., Lutz B., Pittman Q. J., Mawe G. M., Sharkey K. A.
Plasticity of mouse enteric synapses mediated through endocannabinoid and purinergic signaling

Jacob Wolfgang, Marsch Rudolph, Marsicano Giovanni, Lutz Beat, Wotjak Carsten T.
Cannabinoid CB1 receptor deficiency increases contextual fear memory under highly aversive conditions and long-term potentiation in vivo
NEUROBIOLOGY OF LEARNING AND MEMORY. 2012; 98 (1): 47-55 Article

Jiang CS, Muller WEG, Schroder HC, Guo YW
Disulfide- and Multisulfide-Containing Metabolites from Marine Organisms
CHEMICAL REVIEWS. 2012; 112 (4): 2179-2207 Review

Jochum KP, Wang XH, Vennemann TW, Sinha B, Muller WEG
Siliceous deep-sea sponge Monorhaphis chuni: A potential paleoclimate archive in ancient animals
CHEMICAL GEOLOGY. 2012; 300: 143-151 Article

Karow Marisa, Sanchez Rodrigo, Schichor Christian, Masserdotti Giacomo, Ortega Felipe, Heinrich Christophe, Gascon Sergio, Khan Muhammad A., Lie D. Chichung, Dellavalle Arianna, Cossu Giulio, Goldbrunner Roland, Goetz Magdalena, Berninger Benedikt
Reprogramming of Pericyte-Derived Cells of the Adult Human Brain into Induced Neuronal Cells
CELL STEM CELL. 2012; 11 (4): 471-476 Article

Mueller Werner E. G., Wang Xiaohong, Grebenjuk Vlad A., Korzhev Michael, Wiens Matthias, Schlossmacher Ute, Schroeder Heinz C.
Nocturnin in the demosponge Suberites domuncula: a potential circadian clock protein controlling glycogenin synthesis in sponges
BIOCHEMICAL JOURNAL. 2012; 448: 233-242 Article

Mueller Werner E. G., Wang Xiaohong, Guo Yue-Wei, Schroeder Heinz C.
Potentiation of the Cytotoxic Activity of Copper by Polyphosphate on Biofilm-Producing Bacteria: A Bioinspired Approach
MARINE DRUGS. 2012; 10 (11): 2369-2387 Article

Muller WEG, Wang XH, Grebenjuk VA, Korzhev M, Wiens M, Schlossmacher U, Schroder HC
Common Genetic Denominators for Ca++-Based Skeleton in Metazoa: Role of Osteoclast-Stimulating Factor and of Carbonic Anhydrase in a Calcareous Sponge
PLOS ONE. 2012; 7 (4): - Article

Muller WEG, Wang XH, Binder M, von Lintig J, Wiens M, Schroder HC
Differential Expression of the Demosponge (Suberites domuncula) Carotenoid Oxygenases in Response to Light: Protection Mechanism Against the Self-Produced Toxic Protein (Suberitine)
MARINE DRUGS. 2012; 10 (1): 177-199 Article

Muller WEG, Wang XH
Silicatein: from chemical through enzymatic silica formation, to synthesis of biomimetic nanomaterials
FEBS JOURNAL. 2012; 279 (10): 1709-1709 Article

Pagliara Stefano, Polini Alessandro, Camposeo Andrea, Schroeder Heinz C., Mueller Werner E. G., Pisignano Dario
Electrical properties of in vitro biomineralized recombinant silicatein deposited by microfluidics
APPLIED PHYSICS LETTERS. 2012; 101 (19):  Article

Pamplona Fabricio A., Ferreira Juliano, de Lima ?, Duarte Filipe Silveira, Bento Allisson Freire, Forner Stefania, Villarinho Jardel G., Bellocchio Luigi, Wotjak Carsten T., Lerner Raissa, Monory Krisztina, Lutz Beat, Canetti Claudio, Matias Isabelle, Calixto Joao Batista, Marsicano Giovanni, Guimaraes Marilia Z. P., Takahashi Reinaldo N.
Anti-inflammatory lipoxin A(4) is an endogenous allosteric enhancer of CB1 cannabinoid receptor

Polini A, Pagliara S, Camposeo A, Cingolani R, Wang XH, Schroder HC, Muller WEG, Pisignano D
Optical properties of in-vitro biomineralised silica
SCIENTIFIC REPORTS. 2012; 2: - Article

Rey Alejandro Aparisi, Purrio Martin, Viveros Maria-Paz, Lutz Beat
Biphasic Effects of Cannabinoids in Anxiety Responses: CB1 and GABA(B) Receptors in the Balance of GABAergic and Glutamatergic Neurotransmission
NEUROPSYCHOPHARMACOLOGY. 2012; 37 (12): 2624-2634 Article

Ruehle S., Rey A. Aparisi, Remmers F., Lutz B.
The endocannabinoid system in anxiety, fear memory and habituation
JOURNAL OF PSYCHOPHARMACOLOGY. 2012; 26 (1): 23-39 Review

Schroder HC, Wang XH, Manfrin A, Yu SH, Grebenjuk VA, Korzhev M, Wiens M, Schlossmacher U, Muller WEG
Acquisition of Structure-guiding and Structure-forming Properties during Maturation from the Pro-silicatein to the Silicatein Form
JOURNAL OF BIOLOGICAL CHEMISTRY. 2012; 287 (26): 22196-22205 Article

Schroder HC, Wang XH, Wiens M, Diehl-Seifert B, Kropf K, Schlossmacher U, Muller WEG
Silicate Modulates the Cross-Talk Between Osteoblasts (SaOS-2) and Osteoclasts (RAW 264.7 Cells): Inhibition of Osteoclast Growth and Differentiation
JOURNAL OF CELLULAR BIOCHEMISTRY. 2012; 113 (10): 3197-3206 Article

Schroeder Heinz C., Wiens Matthias, Schlossmacher Ute, Brandt David, Mueller Werner E. G.
Silicatein-Mediated Polycondensation of Orthosilicic Acid: Modeling of a Catalytic Mechanism Involving Ring Formation
SILICON. 2012; 4 (1): 33-38 Article

Schulte Kirsten, Steingrueber Nina, Jergas Bernd, Redmer Agnes, Kurz Christina Maria, Buchalla Rainer, Lutz Beat, Zimmer Andreas, Schlicker Eberhard
Cannabinoid CB1 receptor activation, pharmacological blockade, or genetic ablation affects the function of the muscarinic auto- and heteroreceptor

Wang XH, Schroder HC, Wiens M, Schlossmacher U, Muller WEG
Advances in Marine Biology. 2012; 62: 231-271 Review; Book Chapter

Wang XH, Schroder HC, Wiens M, Ushijima H, Muller WEG
Bio-silica and bio-polyphosphate: applications in biomedicine (bone formation)
CURRENT OPINION IN BIOTECHNOLOGY. 2012; 23 (4): 570-578 Review

Wang XH, Wiens M, Schlossmacher U, Jochum KP, Schroder HC, Muller WEG
Bio-Sintering/Bio-Fusion of Silica in Sponge Spicules

Wang XH, Gan L, Wiens M, Schlossmacher U, Schroder HC, Muller WEG
Distribution of Microfossils Within Polymetallic Nodules: Biogenic Clusters Within Manganese Layers
MARINE BIOTECHNOLOGY. 2012; 14 (1): 96-105 Article

Wang XH, Schröder HC, Diehl-Seifert B, Kropf K, Schloßmacher U, Wiens M, Müller WEG
Dual effect of inorganic polymeric phosphate/polyphosphate on osteoblasts and osteoclasts in vitro
Journal of Tissue Engineering and Regenerative Medicine. 2012: 1

Wang XH, Fan XT, Schroder HC, Muller WEG
Flashing light in sponges through their siliceous fiber network: A new strategy of "neuronal transmission" in animals
CHINESE SCIENCE BULLETIN. 2012; 57 (25): 3300-3311 Article

Wang XH, Schröder HC, Wiens M, Gan L, Tremel W, Müller WEG
From biosilica of sponges (Demospongiae and Hexactinellida) to fabricated biomedical materials. Beitrag in: Handbook of Marine Natural Products
Herausgeber: Fattorusso, Ernesto, Springer Berlin, 2012, S.1259-1284

Wang XH, Schloßmacher U, Wang SF, Schröder HC, Wiens M, Batel R, Müller WEG
From nanoparticles via microtemplates and milliparticles to deep-sea nodules: biogenically driven mineral formation
Frontiers of Materials Science. 2012; 6 (2): 97-115

Wang XH, Schroder HC, Wang K, Kaandorp JA, Muller WEG
Genetic, biological and structural hierarchies during sponge spicule formation: from soft sol-gels to solid 3D silica composite structures
SOFT MATTER. 2012; 8 (37): 9501-9518 Review

Wang XH, Brandt D, Thakur NL, Wiens M, Batel R, Schröder HC, Müller WEG
Molecular cross-talk between sponge host and associated microbes
Phytochemistry Reviews. 2012: 1-22

Wang XH, Schlossmacher U, Wiens M, Batel R, Schroder HC, Muller WEG
Silicateins, silicatein interactors and cellular interplay in sponge skeletogenesis: formation of glass fiber-like spicules
FEBS JOURNAL. 2012; 279 (10): 1721-1736 Review

Wiens M, Link T, Elkhooly TA, Isbert S, Muller WEG
Formation of a micropatterned titania photocatalyst by microcontact printed silicatein on gold surfaces
CHEMICAL COMMUNICATIONS. 2012; 48 (92): 11331-11333 Article

Wojtalla Alexandra, Herweck Frank, Granzow Michaela, Klein Sabine, Trebicka Jonel, Huss Sebastian, Lerner Raissa, Lutz Beat, Schildberg Frank Alexander, Knolle Percy Alexander, Sauerbruch Tilman, Singer Manfred Vincenz, Zimmer Andreas, Siegmund Soeren Volker
The endocannabinoid N-arachidonoyl dopamine (NADA) selectively induces oxidative stress-mediated cell death in hepatic stellate cells but not in hepatocytes

Publikationen 2011

Aiello A, Fattorusso E, Menna M, Vitalone R, Schroder HC, Muller WEG
Mumijo Traditional Medicine: Fossil Deposits from Antarctica (Chemical Composition and Beneficial Bioactivity)

Aiyelaagbe OO, Hamid AA, Fattorusso E, Taglialatela-Scafati O, Schroder HC, Muller WEG
Cytotoxic Activity of Crude Extracts as well as of Pure Components from Jatropha Species, Plants Used Extensively in African Traditional Medicine

Albayram O, Alferink J, Pitsch J, Piyanova A, Neitzert K, Poppensieker K, Mauer D, Michel K, Legler A, Becker A, Monory K, Lutz B, Zimmer A, Bilkei-Gorzo A
Role of CB1 cannabinoid receptors on GABAergic neurons in brain aging

Andre R, Tahir MN, Link T, Jochum FD, Kolb U, Theato P, Berger R, Wiens M, Schroder HC, Muller WEG, Tremel W
Chemical Mimicry: Hierarchical 1D TiO2@ZrO2 Core-Shell Structures Reminiscent of Sponge Spicules by the Synergistic Effect of Silicatein-alpha and Silintaphin-1
LANGMUIR. 2011; 27 (9): 5464-5471 Article

Andre R, Tahir MN, Schroder HCC, Muller WEG, Tremel W
Enzymatic Synthesis and Surface Deposition of Tin Dioxide using Silicatein-alpha
CHEMISTRY OF MATERIALS. 2011; 23 (24): 5358-5365 Article

Andre R, Natalio F, Humanes M, Leppin J, Heinze K, Wever R, Schroder HC, Muller WEG, Tremel W
V2O5 Nanowires with an Intrinsic Peroxidase-Like Activity
ADVANCED FUNCTIONAL MATERIALS. 2011; 21 (3): 501-509 Article

Argaw A, Duff G, Zabouri N, Cecyre B, Chaine N, Cherif H, Tea N, Lutz B, Ptito M, Bouchard JF
Concerted Action of CB1 Cannabinoid Receptor and Deleted in Colorectal Cancer in Axon Guidance
JOURNAL OF NEUROSCIENCE. 2011; 31 (4): 1489-1499 Article

Baranowska M, Schlossmacher U, McKenzie JD, Muller WEG, Schroder HC
Isolation and Characterization of Adhesive Secretion from Cuvierian Tubules of Sea Cucumber Holothuria forskali (Echinodermata: Holothuroidea)

Blazquez C, Chiarlone A, Sagredo O, Aguado T, Pazos MR, Resel E, Palazuelos J, Julien B, Salazar M, Borner C, Benito C, Carrasco C, Diez-Zaera M, Paoletti P, Diaz-Hernandez M, Ruiz C, Sendtner M, Lucas JJ, de Yebenes JG, Marsicano G, Monory K, Lutz B, Romero J, Alberch J, Gines S, Kraus J, Fernandez-Ruiz J, Galve-Roperh I, Guzman M
Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease
BRAIN. 2011; 134: 119-136 Article

Carey MR, Myoga MH, McDaniels KR, Marsicano G, Lutz B, Mackie K, Regehr WG
Presynaptic CB1 Receptors Regulate Synaptic Plasticity at Cerebellar Parallel Fiber Synapses
JOURNAL OF NEUROPHYSIOLOGY. 2011; 105 (2): 958-963 Article

Chatel A, Hamer B, Jaksic Z, Vucelic V, Talarmin H, Dorange G, Schroder HC, Muller WEG
Induction of apoptosis in mussel Mytilus galloprovincialis gills by model cytotoxic agents
ECOTOXICOLOGY. 2011; 20 (8): 2030-2041 Article

Chatel A, Talarmin H, Hamer B, Schroder HC, Muller WEG, Dorange G
MAP kinase cell signaling pathway as biomarker of environmental pollution in the sponge Suberites domuncula
ECOTOXICOLOGY. 2011; 20 (8): 1727-1740 Article

Chianese G, Fattorusso E, Aiyelaagbe OO, Luciano P, Schroder HC, Muller WEG, Taglialatela-Scafati O
Spirocurcasone, a Diterpenoid with a Novel Carbon Skeleton from Jatropha curcas
ORGANIC LETTERS. 2011; 13 (2): 316-319 Article

Ebada SS, Schulz B, Wray V, Totzke F, Kubbutat MHG, Muller WEG, Hamacher A, Kassack MU, Lin WH, Proksch P
Arthrinins A-D: Novel diterpenoids and further constituents from the sponge derived fungus Arthrinium sp.
BIOORGANIC & MEDICINAL CHEMISTRY. 2011; 19 (15): 4644-4651 Article

Haring M, Kaiser N, Monory K, Lutz B
Circuit Specific Functions of Cannabinoid CB1 Receptor in the Balance of Investigatory Drive and Exploration
PLOS ONE. 2011; 6 (11): - Article

Hoyer FF, Steinmetz M, Zimmer S, Becker A, Lutjohann D, Buchalla R, Zimmer A, Nickenig G
Atheroprotection via cannabinoid receptor-2 is mediated by circulating and vascular cells in vivo

Kalyuzhnaya OV, Krasko AG, Grebenyuk VA, Itskovich VB, Semiturkina NA, Solovarov IS, Mueller WEG, Belikov SI
Freshwater sponge silicateins: Comparison of gene sequences and exon-intron structure
MOLECULAR BIOLOGY. 2011; 45 (4): 567-575 Article

Kamprath K, Romo-Parra H, Haring M, Gaburro S, Doengi M, Lutz B, Pape HC
Short-Term Adaptation of Conditioned Fear Responses Through Endocannabinoid Signaling in the Central Amygdala
NEUROPSYCHOPHARMACOLOGY. 2011; 36 (3): 652-663 Article

Kasper J, Hermanns MI, Bantz C, Maskos M, Stauber R, Pohl C, Unger RE, Kirkpatrick JC
Inflammatory and cytotoxic responses of an alveolar-capillary coculture model to silica nanoparticles: Comparison with conventional monocultures

Klugmann M, Klippenstein V, Leweke FM, Spanagel R, Schneider M
Cannabinoid exposure in pubertal rats increases spontaneous ethanol consumption and NMDA receptor associated protein levels

Liu HB, Edrada-Ebel R, Ebel R, Wang Y, Schulz B, Draeger S, Muller WEG, Wray V, Lin WH, Proksch P
Ophiobolin Sesterterpenoids and Pyrrolidine Alkaloids from the Sponge-Derived Fungus Aspergillus ustus
HELVETICA CHIMICA ACTA. 2011; 94 (4): 623-631 Article

Lukic-Bilela L, Perovic-Ottstadt S, Walenta S, Natalio F, Plese B, Link T, Muller WEG
ATP distribution and localization of mitochondria in Suberites domuncula (Olivi 1792) tissue
JOURNAL OF EXPERIMENTAL BIOLOGY. 2011; 214 (10): 1748-1753 Article

Luthringer B, Isbert S, Muller WEG, Zilberberg C, Thakur NL, Worheide G, Stauber RH, Kelve M, Wiens M
Poriferan survivin exhibits a conserved regulatory role in the interconnected pathways of cell cycle and apoptosis
CELL DEATH AND DIFFERENTIATION. 2011; 18 (2): 201-213 Article

Mersmann N, Tkachev D, Jelinek R, Roth PT, Mobius W, Ruhwedel T, Ruhle S, Weber-Fahr W, Sartorius A, Klugmann M
Aspartoacylase-LacZ Knockin Mice: An Engineered Model of Canavan Disease
PLOS ONE. 2011; 6 (5): - Article

Muller WEG, Wang XH, Wiens M, Schlossmacher U, Jochum KP, Schroder HC
Hardening of bio-silica in sponge spicules involves an aging process after its enzymatic polycondensation: Evidence for an aquaporin-mediated water absorption

Muller WEG, Wang XH, Diehl-Seifert B, Kropf K, Schlossmacher U, Lieberwirth I, Glasser G, Wiens M, Schroder HC
Inorganic polymeric phosphate/polyphosphate as an inducer of alkaline phosphatase and a modulator of intracellular Ca2+ level in osteoblasts (SaOS-2 cells) in vitro
ACTA BIOMATERIALIA. 2011; 7 (6): 2661-2671 Article

Muller WEG, Binder M, von Lintig J, Guo YW, Wang XH, Kaandorp JA, Wiens M, Schroder HC
Interaction of the retinoic acid signaling pathway with spicule formation in the marine sponge Suberites domuncula through activation of bone morphogenetic protein-1

Müller WEG
Molecular Biomineralization: Aquatic Organisms Forming Extraordinary Materials. Beitrag in: Progress in Molecular and Subcellular Biology / Marine Molecular Biotechnology
Springer 2011, S.414

Müller WEG, Wang XH, Chen AL, Hu SX, Gan L, Schröder HC, Schloßmacher U, Wiens M
The unique invention of the siliceous sponges: their enzymatically made bio-silica skeleton
Prog Mol Subcell Biol.. 2011: 251-281

Perina D, Bosnar MH, Mikoc A, Muller WEG, Cetkovic H
Characterization of Nme6-like gene/protein from marine sponge Suberites domuncula

Polini A, Pagliara S, Camposeo A, Biasco A, Schroder HC, Muller WEG, Pisignano D
Biosilica Electrically-Insulating Layers by Soft Lithography-Assisted Biomineralisation with Recombinant Silicatein
ADVANCED MATERIALS. 2011; 23 (40): 4674-+ Article

Qin S, Müller WEG, Cooper EL
Marine biotechnology
Evidence-based Compl Altern Medicine (eCAM). 2011: 2

Remmers F, Delemarre-van de Waal HA
Developmental Programming of Energy Balance and Its Hypothalamic Regulation
ENDOCRINE REVIEWS. 2011; 32 (2): 272-311 Review

Rossi S, Furlan R, De Chiara V, Muzio L, Musella A, Motta C, Studer V, Cavasinni F, Bernardi G, Martino G, Cravatt BF, Lutz B, Maccarrone M, Centonze D
Cannabinoid CB1 receptors regulate neuronal TNF-alpha effects in experimental autoimmune encephalomyelitis
BRAIN BEHAVIOR AND IMMUNITY. 2011; 25 (6): 1242-1248 Article

Rozas EE, Albano RM, Lobo-Hajdu G, Muller WEG, Schroder HC, Custodio MR
BRAZILIAN JOURNAL OF MICROBIOLOGY. 2011; 42 (4): 1560-1568 Article

Schicho R, Bashashati M, Bawa M, McHugh D, Saur D, Hu HM, Zimmer A, Lutz B, Mackie K, Bradshaw HB, McCafferty DM, Sharkey KA, Storr M
The Atypical Cannabinoid O-1602 Protects Against Experimental Colitis and Inhibits Neutrophil Recruitment
INFLAMMATORY BOWEL DISEASES. 2011; 17 (8): 1651-1664 Article

Schlossmacher U, Wiens M, Schroder HC, Wang XH, Jochum KP, Muller WEG
Silintaphin-1-interaction with silicatein during structure-guiding bio-silica formation
FEBS JOURNAL. 2011; 278 (7): 1145-1155 Article

Schröder HC, Wiens M, Wang XH, Schloßmacher U, Müller WEG
Biosilica-based strategies for treatment of osteoporosis and other bone diseases
Prog Mol Subcell Biol.. 2011: 285-317

Stifanic M, Batel R, Muller WEG
Tubulin polymerization promoting protein (TPPP) ortholog from Suberites domuncula and comparative analysis of TPPP/p25 gene family
BIOLOGIA. 2011; 66 (1): 111-120 Article

Tenzer S, Docter D, Rosfa S, Wlodarski A, Kuharev J, Rekik A, Knauer SK, Bantz C, Nawroth T, Bier C, Sirirattanapan J, Mann W, Treuel L, Zellner R, Maskos M, Schild H, Stauber RH
Nanoparticle Size Is a Critical Physicochemical Determinant of the Human Blood Plasma Corona: A Comprehensive Quantitative Proteomic Analysis
ACS NANO. 2011; 5 (9): 7155-7167 Article

Valor LM, Pulopulos MM, Jimenez-Minchan M, Olivares R, Lutz B, Barco A
Ablation of CBP in Forebrain Principal Neurons Causes Modest Memory and Transcriptional Defects and a Dramatic Reduction of Histone Acetylation But Does Not Affect Cell Viability
JOURNAL OF NEUROSCIENCE. 2011; 31 (5): 1652-1663 Article

Wang XH, Wang SF, Gan L, Schlossmacher U, Zhou F, Jochum KP, Wiens M, Schröder HC, Müller WEG
Advances in research on siliceous sponge spicules: Novel insight into the understanding of biomineralization mechanisms and bionic applications
Acta Geoscientica Sinica. 2011; 32: 129-141

Wang SF, Wang XH, Gan L, Wiens M, Schröder HC, Müller WEG
Biosilica-glass formation using enzymes from sponges [silicatein]: Basic aspects and application in biomedicine [bone reconstitution material and osteoporosis]
Frontiers of Materials Science. 2011; 5 (3): 266-281

Wang XH, Wiens M, Schroder HC, Jochum KP, Schlossmacher U, Gotz H, Duschner H, Muller WEG
Circumferential spicule growth by pericellular silica deposition in the hexactinellid sponge Monorhaphis chuni
JOURNAL OF EXPERIMENTAL BIOLOGY. 2011; 214 (12): 2047-2056 Article

Wang XH, Müller WEG
Complex structures – smart solutions: formation of siliceous spicules
Communicative and integrative biology. 2011; 4 (6): 684-688

Wang XH, Peine F, Schmidt A, Schroder HC, Wiens M, Schlossmacher U, Muller WEG
Concept of Biogenic Ferromanganese Crust Formation: Coccoliths as Bio-seeds in Crusts from Central Atlantic Ocean (Senghor Seamount/Cape Verde)
NATURAL PRODUCT COMMUNICATIONS. 2011; 6 (5): 679-688 Article

Wang XH, Wiens M, Schroder HC, Schlossmacher U, Pisignano D, Jochum KP, Muller WEG
Evagination of Cells Controls Bio-Silica Formation and Maturation during Spicule Formation in Sponges
PLOS ONE. 2011; 6 (6): - Article

Wang XH, Zeng LS, Wiens M, Schlossmacher U, Jochum KP, Schroder HC, Muller WEG
Evidence for a biogenic, microorganismal origin of rock varnish from the Gangdese Belt of Tibet
MICRON. 2011; 42 (5): 401-411 Review

Wang XH, Schröder HC, Müller WEG
Flashing light in sponges through their siliceous fiber network: a new strategy of "neuronal transmission" in animals
Chinese Science Bulletin. 2011: 1-12

Wang XH, Wiens M, Divekar M, Grebenjuk VA, Schroder HC, Batel R, Muller WEG
Isolation and Characterization of a Mn(II)-Oxidizing Bacillus Strain from the Demosponge Suberites domuncula
MARINE DRUGS. 2011; 9 (1): 1-28 Article

Wang XH, Wiens M, Schröder HC, Schloßmacher U, Müller WEG
Molecular Biomineralization: Toward an Understanding of the Biogenic Origin of Polymetallic Nodules, Seamount Crusts, and Hydrothermal Vents
Prog Mol Subcell Biol.. 2011: 77-100

Wang XH, Schroder HC, Brandt D, Wiens M, Lieberwirth I, Glasser G, Schlossmacher U, Wang SF, Muller WEG
Sponge Biosilica Formation Involves Syneresis Following Polycondensation in vivo
CHEMBIOCHEM. 2011; 12 (15): 2316-2324 Article

Wang X, Gan L, Jochum KP, Schroder HC, Muller WEG
The largest Bio-Silica Structure on Earth: The Giant Basal Spicule from the Deep-Sea Glass Sponge Monorhaphis chuni

Wiens M, Schroder HC, Korzhev M, Wang XH, Batel R, Muller WEG
Inducible ASABF-Type Antimicrobial Peptide from the Sponge Suberites domuncula: Microbicidal and Hemolytic Activity in Vitro and Toxic Effect on Molluscs in Vivo
MARINE DRUGS. 2011; 9 (10): 1969-1994 Article

Wiens M, Schroder HC, Wang XH, Link T, Steindorf D, Muller WEG
Isolation of the Silicatein-alpha Interactor Silintaphin-2 by a Novel Solid-Phase Pull-Down Assay
BIOCHEMISTRY. 2011; 50 (12): 1981-1990 Article

Zhou YM, Mandi A, Debbab A, Wray V, Schulz B, Muller WEG, Lin WH, Proksch P, Kurtan T, Aly AH
New Austalides from the Sponge-Associated Fungus Aspergillus sp.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2011; (30): 6009-6019 Article