Auswahl von Originalpublikationen aus der AG Molekulare Tumorbiologie seit 2010

• Wiesmann N, Gieringer R, Grus F, Brieger J. Phosphoproteome Profiling Reveals Multifunctional Protein NPM1 as part of the Irradiation Response of Tumor Cells. Transl Oncol. 2019 Feb;12(2):308-319. doi: 10.1016/j.tranon.2018.10.015. Epub 2018 Nov 16. PubMed PMID: 30453269; PubMed Central PMCID: PMC6240713.
• Wiesmann N, Kluenker M, Demuth P, Brenner W, Tremel W, Brieger J. Zinc overload mediated by zinc oxide nanoparticles as innovative anti-tumor agent. J Trace Elem Med Biol. 2019 Jan;51:226-234. doi: 10.1016/j.jtemb.2018.08.002. Epub 2018 Aug 7. PubMed PMID: 30115501.
• Hu M, Korschelt K, Viel M, Wiesmann N, Kappl M, Brieger J, Landfester K, Thérien-Aubin H, Tremel W. Nanozymes in Nanofibrous Mats with Haloperoxidase-Like Activity to Combat Biofouling. ACS Appl Mater Interfaces. 2018 Nov 30. doi: 10.1021/acsami.8b16307. [Epub ahead of print] PubMed PMID: 30499648.
• Heller M, Kumar VV, Pabst A, Brieger J, Al-Nawas B, Kämmerer PW. Osseous response on linear and cyclic RGD-peptides immobilized on titanium surfaces in vitro and in vivo. J Biomed Mater Res A. 2018 Feb;106(2):419-427. doi: 10.1002/jbm.a.36255. Epub 2017 Oct 17. PubMed PMID: 28971567.
• Watermann A, Brieger J. Mesoporous Silica Nanoparticles as Drug Delivery Vehicles in Cancer. Nanomaterials (Basel). 2017 Jul 22;7(7). pii: E189. doi: 10.3390/nano7070189. Review. PubMed PMID: 28737672; PubMed Central PMCID: PMC5535255.
• Affolter A, Samosny G, Heimes AS, Schneider J, Weichert W, Stenzinger A, Sommer K, Jensen A, Mayer A, Brenner W, Mann WJ, Brieger J. Multikinase inhibitors sorafenib and sunitinib as radiosensitizers in head and neck cancer cell lines. Head Neck. 2017 Apr;39(4):623-632. doi: 10.1002/hed.24557. Epub 2017 Feb 21. PubMed PMID: 28221700.
• Korschelt K, Ragg R, Metzger CS, Kluenker M, Oster M, Barton B, Panthöfer M, Strand D, Kolb U, Mondeshki M, Strand S, Brieger J, Nawaz Tahir M, Tremel W. Glycine-functionalized copper(ii) hydroxide nanoparticles with high intrinsic superoxide dismutase activity. Nanoscale. 2017 Mar 17;9(11):3952-3960. doi: 10.1039/c6nr09810j. PubMed PMID: 28265620.
• Wiesmann N, Strozynski J, Beck C, Zimmermann N, Mendler S, Gieringer R, Schmidtmann I, Brieger J. Knockdown of hnRNPK leads to increased DNA damage after irradiation and reduces survival of tumor cells. Carcinogenesis. 2017 Mar 1;38(3):321-328. doi: 10.1093/carcin/bgx006. PubMed PMID: 28426877.
• Mayer A, Zahnreich S, Brieger J, Vaupel P, Schmidberger H. Downregulation of EGFR in hypoxic, diffusion-limited areas of squamous cell carcinomas of the head and neck. Br J Cancer. 2016 Nov 22;115(11):1351-1358. doi: 10.1038/bjc.2016.336. Epub 2016 Nov 1. PubMed PMID: 27802455; PubMed Central PMCID: PMC5129814.
• Heller M, Frerick-Ochs EV, Bauer HK, Schiegnitz E, Flesch D, Brieger J, Stein R, Al-Nawas B, Brochhausen C, Thüroff JW, Unger RE, Brenner W. Tissue engineered pre-vascularized buccal mucosa equivalents utilizing a primary triculture of epithelial cells, endothelial cells and fibroblasts. Biomaterials. 2016 Jan;77:207-15. doi: 10.1016/j.biomaterials.2015.10.073. Epub 2015 Oct 30. PubMed PMID: 26606446.
• Metzger CS, Koutsimpelas D, Brieger J. Transcriptional regulation of the VEGF gene in dependence of individual genomic variations. Cytokine. 2015 Dec;76(2):519-526. doi: 10.1016/j.cyto.2015.07.015. Epub 2015 Jul 21. Review. PubMed PMID: 26209503.
• Kämmerer PW, Al-Nawas B, Kalkan S, Liese J, Fruth K, Frerich B, Brieger J. Angiogenesis-related prognosis in patients with oral squamous cell carcinoma-role of the VEGF +936 C/T polymorphism. J Oral Pathol Med. 2015 Jul;44(6):429-36. doi: 10.1111/jop.12254. Epub 2014 Sep 12. PubMed PMID: 25213013.
• Heller M, Kämmerer PW, Al-Nawas B, Luszpinski MA, Förch R, Brieger J. The effect of extracellular matrix proteins on the cellular response of HUVECS and HOBS after covalent immobilization onto titanium. J Biomed Mater Res A. 2015 Jun;103(6):2035-44. doi: 10.1002/jbm.a.35340. Epub 2014 Oct 14 PubMed PMID: 25256962.
• Heim J, Felder E, Tahir MN, Kaltbeitzel A, Heinrich UR, Brochhausen C, Mailänder V, Tremel W, Brieger J. Genotoxic effects of zinc oxide nanoparticles. Nanoscale. 2015 May 21;7(19):8931-8. doi: 10.1039/c5nr01167a. PubMed PMID: 25916659.
•  Strozynski J, Heim J, Bunbanjerdsuk S, Wiesmann N, Zografidou L, Becker SK, Meierl AM, Gouveris H, Lüddens H, Grus F, Brieger J. Proteomic identification of the heterogeneous nuclear ribonucleoprotein K as irradiation responsive protein related to migration. J Proteomics. 2015 Jan 15;113:154-61. doi: 10.1016/j.jprot.2014.09.017. Epub 2014 Oct 2. PubMed PMID: 25281771.
• Drigotas M, Affolter A, Mann WJ, Brieger J. Reactive oxygen species activation of MAPK pathway results in VEGF upregulation as an undesired irradiation response. J Oral Pathol Med. 2013 Sep;42(8):612-9. doi: 10.1111/jop.12056. Epub 2013 Mar 11. PubMed PMID: 23480207.
• Kämmerer PW, Koch FP, Schiegnitz E, Kumar VV, Berres M, Toyoshima T, Al-Nawas B, Brieger J. Associations between single-nucleotide polymorphisms of the VEGF gene and long-term prognosis of oral squamous cell carcinoma. J Oral Pathol Med. 2013 May;42(5):374-81. doi: 10.1111/jop.12026. Epub 2012 Dec 10. PubMed PMID: 23227881.
• Kämmerer PW, Koch FP, Santoro M, Babaryka G, Biesterfeld S, Brieger J, Kunkel M. Prospective, blinded comparison of cytology and DNA-image cytometry of brush biopsies for early detection of oral malignancy. Oral Oncol. 2013 May;49(5):420-6. doi: 10.1016/j.oraloncology.2012.12.006. Epub 2013 Jan 11. PubMed PMID: 23318121.
• Affolter A, Drigotas M, Fruth K, Schmidtmann I, Brochhausen C, Mann WJ, Brieger J. Increased radioresistance via G12S K-Ras by compensatory upregulation of MAPK and PI3K pathways in epithelial cancer. Head Neck. 2013 Feb;35(2):220-8. doi: 10.1002/hed.22954. Epub 2012 Feb 2. PubMed PMID: 22302684.
•  Zhu CJ, Fruth K, Schneider A, Mann WJ, Brieger J. Impact of ozone exposure on prostaglandin release in nasal polyps. Eur Arch Otorhinolaryngol. 2012 Jun;269(6):1623-8. doi: 10.1007/s00405-011-1856-8. Epub 2011 Dec 1. PubMed PMID: 22130916.
•  Fruth K, Weber S, Okcu Y, Noppens R, Klein KU, Joest E, Hedrich J, Thilemann S, Pogorzelski B, Koutsimpelas D, Fischer S, Muennemann K, Affolter A, Heinrich UR, Brochhausen C, Schmidtmann I, Mann WJ, Schmidberger H, Schreiber LM, Brieger J. Increased basic fibroblast growth factor release and proliferation in xenotransplanted squamous cell carcinoma after combined irradiation/anti-vascular endothelial growth factor treatment. Oncol Rep. 2012 May;27(5):1573-9. doi: 10.3892/or.2012.1654. Epub 2012 Jan 26. PubMed PMID: 22294154.
• Koutsimpelas D, Pongsapich W, Heinrich U, Mann S, Mann WJ, Brieger J. Promoter methylation of MGMT, MLH1 and RASSF1A tumor suppressor genes in head and neck squamous cell carcinoma: pharmacological genome demethylation reduces proliferation of head and neck squamous carcinoma cells. Oncol Rep. 2012 Apr;27(4):1135-41. doi: 10.3892/or.2012.1624. Epub 2012 Jan 9. PubMed PMID: 22246327; PubMed Central PMCID: PMC3583513.
• Brieger J, Mann SA, Pongsapich W, Koutsimpelas D, Fruth K, Mann WJ. Pharmacological genome demethylation increases radiosensitivity of head and neck squamous carcinoma cells. Int J Mol Med. 2012 Mar;29(3):505-9. doi: 10.3892/ijmm.2011.843. Epub 2011 Nov 21. PubMed PMID: 22109647.
• Koutsimpelas D, Ruerup G, Mann WJ, Brieger J. Lack of neurofibromatosis type 2 gene promoter methylation in sporadic vestibular schwannomas. ORL J Otorhinolaryngol Relat Spec. 2012;74(1):33-7. doi: 10.1159/000334968. Epub 2012 Jan 13. PubMed PMID: 22249120.
• Affolter A, Fruth K, Brochhausen C, Schmidtmann I, Mann WJ, Brieger J. Activation of mitogen-activated protein kinase extracellular signal-related kinase in head and neck squamous cell carcinomas after irradiation as part of a rescue mechanism. Head Neck. 2011 Oct;33(10):1448-57. doi: 10.1002/hed.21623. Epub 2010 Nov 10. PubMed PMID: 21928417.
• Koutsimpelas D, Felmeden U, Mann WJ, Brieger J. Analysis of cytogenetic aberrations in sporadic vestibular schwannoma by comparative genomic hybridization. J Neurooncol. 2011 Jul;103(3):437-43. doi: 10.1007/s11060-010-0412-5. Epub 2010 Sep 26. PubMed PMID: 20872275.
• Thiel UJ, Feltens R, Adryan B, Gieringer R, Brochhausen C, Schuon R, Fillies T, Grus F, Mann WJ, Brieger J. Analysis of differentially expressed proteins in oral squamous cell carcinoma by MALDI-TOF MS. J Oral Pathol Med. 2011 May;40(5):369-79. doi: 10.1111/j.1600-0714.2010.00982.x. Epub 2010 Dec 17. PubMed PMID: 21166718.
• Kämmerer PW, Heller M, Brieger J, Klein MO, Al-Nawas B, Gabriel M. Immobilisation of linear and cyclic RGD-peptides on titanium surfaces and their impact on endothelial cell adhesion and proliferation. Eur Cell Mater. 2011 Apr 11;21:364-72. PubMed PMID: 21484706.
• Gouveris H, Lehmann CG, Heinrich UR, Mann WJ, Brieger J. Genomic changes in salivary gland pleomorphic adenomas detected by comparative genomic hybridization. Neoplasma. 2011;58(2):97-103. PubMed PMID: 21275457.
• Kämmerer PW, Toyoshima T, Eletr S, Kämmerer P, Kuhr K, Al-Nawas B, Brieger J. Single nucleotide polymorphisms of the vascular endothelial growth factor gene associated with incidence of oral squamous cell carcinoma. J Oral Pathol Med. 2010 Nov;39(10):786-92. doi: 10.1111/j.1600-0714.2010.00904.x. PubMed PMID: 20618614.
• Brieger J, Pongsapich W, Mann SA, Hedrich J, Fruth K, Pogozelski B, Mann WJ. Demethylation treatment restores hic1 expression and impairs aggressiveness of head and neck squamous cell carcinoma. Oral Oncol. 2010 Sep;46(9):678-83. doi: 10.1016/j.oraloncology.2010.06.016. Epub 2010 Aug 21. PubMed PMID: 20729134.
• Koch FP, Kämmerer PW, Kämmerer P, Al-Nawas B, Brieger J. Influence of class M1 glutathione S-transferase (GST Mu) polymorphism on GST M1 gene expression level and tumor size in oral squamous cell carcinoma. Oral Oncol. 2010 Feb;46(2):128-33. doi: 10.1016/j.oraloncology.2009.11.014. Epub 2010 Jan 8. PubMed PMID: 20060357.

Das vollständige Publikationsverzeichnis von Prof. Brieger finden Sie unter: www.ncbi.nlm.nih.gov/pubmed