Dr. rer. nat. Thorsten Enklaar

Universitätsmedizin Mainz
Zentrum für Kinder- und Jugendmedizin
Molekulargenetisches Labor AG Prawitt

Langenbeckstr. 1
D-55101 Mainz
 
Tel.: +0049 (0)6131 17-2020
Fax.: +0049 (0)6131 17-6610
 enklaar@molgen.medizin.uni-mainz.de

Forschungsinteressen

• Genomisches Imprinting Beckwith-Wiedemann-Syndrom assoziierter Gene
• Untersuchung allelspezifischer CpG-Methylierung, Bisulfit-Modifikation
• ChIP-Analyse allelspezifischer Histonmodifikationen
• DNA-DNA-Interaktionen, teritoriale Organisation und Regulation der DNA im Zellkern, 4C
• Gewebespezifität des genomischen Imprinting in der murinen Entwicklung
• Rolle des Ascl3-Gens in der Speicheldrüsenentwicklung
• Genexpressionsregulation (Transkriptionskontrolle)
• Asynchrone Replikation geprägter Gene

Publikationen

• Enklaar T., Zabel B., Prawitt D. (2006)
  Beckwith-Wiedemann syndrome: multiple molecular mechanisms
  Expert.Rev.Mol.Med. (8) 17: 1-19
• Prawitt D. & Enklaar T., Gärtner-Rupprecht B., Spangenberg C., Lausch E., Reutzel D., Fees S., Korzon M., Brozek I., Limon J., Housman DE., Pelletier J., Zabel B. (2005)
  Microdeletion and IGF2 loss of imprinting in a cascade causing Beckwith-Wiedemann syndrome with Wilms' tumor.
  Nat Genet. 37 (8): 785-786
• Prawitt D. & Enklaar T., Gärtner-Rupprecht B., Spangenberg C., Oswald M., Lausch E., Schmidtke P., Reutzel D., Fees S., Lucito R., Korzon M., Brozek I., Limon J., Housman DE., Pelletier J., Zabel B. (2005)
  Microdeletion of target sites for insulator protein CTCF in a chromosome 11p15 imprinting center in Beckwith–Wiedemann syndrome and Wilms’ tumor.
  Proc.Nat.Acad.Sci. 102 (11): 4085-4090
• Trost TM, Lausch EU, Fees SA, Schmitt S, Enklaar T, Reutzel D, Brixel LR, Schmidtke P, Maringer M, Schiffer IB, Heimerdinger CK, Hengstler JG, Fritz G, Bockamp EO, Prawitt D, Zabel BU, Spangenberg C. (2005)
  Premature senescence is a primary fail-safe mechanism of ERBB2-driven tumorigenesis in breast carcinoma cells.
  Cancer Res. 65 (3): 840-849
• Bahn, A.; Prawitt, D.; Buttler, D.; Reid, G.; Enklaar, T.; Wolff, N. A.; Ebbinghaus, C.; Hillemann, A.; Schulten, H. J.; Gunawan, B.; Fuzesi, L.; Zabel, B., Burckhardt, G. (2000)
  Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene.
  Biochem. Biophys. Res. Commun. 275 (2): 623-630
• Enklaar, T.; Eßwein, M.; Oswald, M.; Hilbert, K.; Winterpacht, A.; Higgins, M.; Zabel, B., Prawitt, D. (2000)
  Mtr1, a novel biallelically expressed gene in the center of the mouse distal chromosome 7 imprinting cluster, is a member of the Trp gene family.
  Genomics 67 (2): 179-187
• Kraemer, C.; Enklaar, T.; Zabel, B., Schmidt, E. R. (2000)
  Mapping and structure of DMXL1, a human homologue of the DmX gene from Drosophila melanogaster coding for a WD repeat protein.
  Genomics 64 (1): 97-101
• Prawitt, D.; Enklaar, T.; Klemm, G.; Gärtner, B.; Spangenberg, C.; Winterpacht, A.; Higgins, M.; Pelletier, J., Zabel, B. (2000)
  Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression.
  Hum. Mol. Genet. 9 (2): 203-216.
• Winterpacht, A.; Endele, S.; Enklaar, T.; Fuhry, M., Zabel, B. (1996)
  Human CLAPS2 encoding AP17, a small chain of the clathrin-associated protein complex: cDNA cloning and chromosomal assignment to 19q13.2-->q13.3.
  Cytogenet. Cell Genet. 75(2-3): 132-135

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