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Gutenberg Health Study

  • Head of study: Professor Philipp Wild, MD


The Gutenberg Health Study is one of the largest population-based and representative prospective cohort studies on cardiovascular disease worldwide. Since April 2007 this interdisciplinary research project is being performed by the Department of Medicine 2 together with other clinics and institutes at the University Medical Centre of the Johannes Gutenberg University Mainz.

It investigates multifactorial influences that are potentially involved in the development of cardiovascular disease, cancer, eye disease, metabolic diseases, diseases of the immune system and mental diseases. The study aims at improving the individual risk prediction for diseases. Therefore, classical risk factors, lifestyle, psychosocial factors, environmental and laboratory parameters as well as the extent of subclinical diseases are investigated. A comprehensive biobank enables biomolecular examinations including a systems biological approach. Within the framework of the work program of the “Clinical Epidemiology” of the CTH questions in the field of thrombosis and hemostasis are researched.

During the baseline visit 15,000 individuals aged 35-75 years were invited to a 5 h examination program in the Gutenberg study center. 2.5 years after the baseline examination a computer-assisted standardized telephone interview and assessment of endpoints was conducted. After 5 years a detailed follow-up examination comparable to the visit at study inclusion is being performed in the study center, a computer-assisted standardized telephone interview and assessment of endpoints follows after 7.5 years. Further follow-up visits of the cohort are envisaged.

The Gutenberg Health Study is supported by the government of Rheinland-Pfalz, the Federal Ministry of Education and Research (BMBF) and the German Center for Research in Cardiovascular Disease (DZHK).

Sponsor: University Medical Center, Johannes Gutenberg University Mainz (research program „Wissen schafft Zukunft“ und „Schwerpunkt Vaskuläre Prävention), the government of Rheinland-Pfalz (“Stiftung Rheinland Pfalz für Innovationen”, AZ 961-386261/733), Boehringer Ingelheim GmbH, and Philips GmbH including an unrestricted grant.

Study Design

German population based, single center, prospective cohort study

Official Title

Gutenberg Health Study


Published; 5-year Follow-up recruiting

Executive Committee

Philipp Wild, Mainz, Manfred Beutel, Mainz, Maria Blettner, Mainz, Karl J. Lackner, Mainz, Norbert Pfeiffer, Mainz, Thomas Münzel, Mainz, Stefan Blankenberg, Hamburg