Platform 4

Genetic Resources

• Establishing mouse models of general interest for thrombosis and hemostasis research
• Generation and quality control management of genetic mouse models
• Dissemination and maintenance of genetic resources

Scientific Platform-Coordiantor

• Kontakt

Professor Wolfram Ruf, MD

Scientific Director CTH, Alexander von Humboldt-Professorship "Experimental Hemostasiology", Deputy Speaker of CTH, Deputy Speaker of CTVB, Principal Investigator DZHK

06131 17-8222

06131 17-3456

Platform-Supervisor

• Kontakt

Sabine Reyda

Research Coordinator

06131 17-8048

References (selection)

• Subramaniam S, Jurk K, Hobohm L, Jäckel S, Saffarzadeh M, Schwierczek K, Wenzel P, Langer F, Reinhardt C, Ruf W. Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus development. Blood 2017;129(16):2291-2302.
• Gur-Cohen S, Itkin T, Chakrabarty S, Graf C, Kollet O, Ludin A, Golan K, Kalinkovich A, Ledergor G, Wong E, Niemeyer E, Porat Z, Erez A, Sagi I, Esmon CT, Ruf W*, Lapidot T*. PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells. Nat Med 2015;21(11):1307-1317.