Platform 1

Intravital Microscopy

Arterial thrombosis is caused by injury of the vascular endothelium or by rupture of atherosclerotic plaques. Consequences can be myocardial infarction or stroke, these are major causes of death worldwide.



One main cause of venous thrombosis is a reduction of blood flow caused by immobility after surgery or during long flights and train journeys. Blood clots often develop in the deep vein legs (deep venous thrombosis, DVT). These clots can break off from vein walls and travel to the lungs, where they can cause a pulmonary embolism.



With the help of various mouse models in combination with intravital microscopy, thrombus formation can be visualised and thus  a real-time representation of the cellular processes in vivo possible. Various mouse thrombosis models have been established in this platform, such as the carotid artery ligation model, vena cava stenosis model and the mesenteric ischaemia-reperfusion model.

Partners using this method

Partners at the CTH

  • Prof. Dr. Wolfram Ruf (Cell Signaling Pathways of the Hemostatic System)
  • Prof. Dr. Philip Wenzel (Vascular Inflammation)
  • Prof. Dr. Christoph Reinhardt (Experimental Hemostasis and Gnotobiotics)

Partners at the University Medical Center Mainz

  • Prof. Dr. Katrin Schäfer (Center for Cardiology – Cardiology I)
  • Prof. Andreas Daiber (II. Department of Medicine and Polyclinic - Molecular Cardiology)
  • Prof. Huige Li (Institute for Pharmacology)

Platform


      Scientific Platform Coordinators

      Univ.-Prof. Dr. Christoph Reinhardt

      Univ.-Prof. Dr. Christoph Reinhardt

      Juniorgroup leader, GFK Fellow, Scientist in the DZHK

      Jun. Prof. Dr. Carsten Deppermann

      Jun. Prof. Dr. Carsten Deppermann

      Juniorgroup leader


      References (selection)