Platform 5
Advanced Diagnostics
The 'Advanced Diagnostics' platform aims to establish innovative diagnostic concepts at the CTH. To this end, we are developing new diagnostic tools that bridge the gap between basic science, clinical research, routine diagnostics and patient care. The focus is on applications enabling the translation of research into clinical practice (bench-to-bedside) as well as the feedback of clinical observations into basic research (bedside-to-bench). Thus, this platform serves as a central link between basic research and patient-oriented research and is firmly embedded in the CTH as an integrated centre for clinical and research.Platform project

A. Adenäuer, Prof Barco, Prof Lämmle and Prof Rossmann have initiated an international registry with a biobank for congenital defects of the kallikrein kininogen system (see fig) funded by the ISTH and DGKL in 2024, for which they are seeking further cooperation partners. It serves the systematic recording and diagnosis of cases with hereditary prekallikrein (PK) deficiency or deficiency of high molecular weight kininogen (HK). Due to the lack of obvious symptoms and the previously erroneously assumed rarity of these protein deficiencies, a comprehensive and well-structured international cohort study has been lacking so far. The cohort study initiated here aims to provide important insights into the physiological and pathophysiological significance of PK and HK, which will help to improve the care of patients with these deficits and advance the development of PK and HK-based therapy options. As part of the study, we offer free functional and molecular genetic PK and HK analysis to participating centres.
Further projects using the platform's expertise
- Prof. Danckwardt: Genomics in Thrombosis and Hemostasis (GinTH) ISTH SSC
- Prof Pierre Morange, Prof. David Alexandre Trégouët, Prof. Danckwardt: non-coding determinants in T&H
- A. Adenäuer, Prof. Schmaier (Case Western Reserve University and UH Cleveland Medical Center), Prof. Lämmle, Prof. Rossmann: Molecular characterisation of historical samples with defects in the kallikrein kininogen system
- Dr. Häuser, Dr. Falter, Dr. Mittler, Dr. Radsak, Dr. Sasca, Prof. Rossmann: Development of ddPCR-based methods for the sensitive quantification of chimerism after bone marrow transplantation and solid organ transplantation from gDNA or cfDNA
- Dr. Häuser, A. Adenäuer, Prof. Rossmann: Characterisation of splice variants to complement modern molecular genetic diagnostics
- Dr. Häuser, A. Adenäuer, PD Dr. O. Beck, Prof. Rossmann, Prof. Lämmle: Importance of molecular genetic tests in the diagnosis of spherocytosis
- S. Popp, Dr. Nitsche, Prof. Rossmann: Integration of functional and molecular genetic diagnostics in primary ciliary dyskinesia (PCD)
- Prof. Vanhoorelbeke (Universität Leuven, Belgien), Prof. Lämmle, Dr. Falter, Prof. Rossmann: Significance of the ADAMTS13 conformation for the pathogenesis of TTP
- Prof. Jurk, A. Adenäuer, Prof. Rossmann: Genetic causes of platelet dysfunction and thrombocythaemia
- Prof. Jurk, Prof. Faber, Prof. Russo, Prof. Rossmann: Patient registry for congenital platelet disorders
- Prof. Lämmle, Dr. v. Auer, Dr. Falter, Prof. Rossmann: Genetic causes and modifiers of TTP (thrombotic thrombocytopenic purpura)
- Prof. Danckwardt, A. Adenäuer, Dr. Häuser, Prof. Rossmann: VWD (von Willebrand disease): Genotype/phenotype ratio
- Dr. Sibbing, Prof. Gori, Prof. Danckwardt, Dr. Wenzel: TROPICAL-ACS (Testing RespOnsiveness To Platelet Inhibition On Chronic AntiplateLet treatment For Acute Coronary Syndromes); contribution of polymorphisms to vascular and platelet function
- Prof. Gori, Prof. Danckwardt: Prevention of in-stent thrombosis
- Dr. Schmidgen, Prof. Gori, Prof. Ruf, Prof. Steinbrink, Prof. Danckwardt: Significance of signalling pathways in cutaneous inflammation
- Dr. Kleis-Fischer, Prof. Grabbe, Prof. Danckwardt: Influence of genetics on wound healing
- This platform is part of the 'Shared Expertise' of the DZHK ('Plattformlobor CTH' - shared expertise SE076)

Professor Sven Danckwardt, MD
Professorship "Experimental Hemostasis and Laboratory Medicine", DZHK Scientist