Junior group 'Clinical Platelet Epidemiology'

Marina Panova-Noeva, MD, MSc, PhD

Group leader

The “Clinical Platelet Epidemiology”, a junior group in the department of Clinical Epidemiology at CTH, aims to introduce and establish epidemiological methodology on standardization of data and biomaterial assessment, and expertise in biostatistics integrating large-scale data sets with various data levels, to platelet research. The working program of the junior group focuses on the investigation of functional characteristics of platelets in patients with acute venous thromboembolism (VTE) and its interrelation with cancer as well as in survivors of both childhood and adult cancer. Generated new data will add evidence on the role of platelets in the pathogenesis of VTE and cancer and the potential application of platelet function tests to the ongoing search for the optimized models to predict vascular risk.

Research interest

Partners of collaboration

Partners at the UMC Mainz: 
Prof. Philipp S. Wild, MD, MSc & Dr. Jürgen Prochaska, MD – Clinical Epidemiology, CTH
Professor Stavros Konstantinides and Dr. Mareike Lankeit – Clinical Trials, CTH 
Professor Ulrich Walter, Dr. Kerstin Jurk - Research Group Platelet Signaling, CTH 
Professor Wolfram Ruf, Dr. Sebastian Schubert - Platelet transcriptomics, CTH 
Professor Thomas Münzel, Center for Cardiology – Cardiology I
Professor Karl J. Lackner - Laboratory Medicine

European Partners: 
Prof. H. ten Cate, Dr. H. Spronk - Maastricht University, NL

Research funding

• BMBF (CTH)_contract Nr: 01EO1503;
• DFG (CVSS)_ contract Nr: WI 3881/2-2
• Bayer (FOCUS BioSeq)_contract Nr: 0070/15

• DZHK _Contract Nr: B18-008_ Cooperation with External Partners

Team - Junior group Clinical Platelet Epidemiology

Thi Huong Lan Do - MD student

Bianca Wagner, M.Sc. – PhD student

Maren Paul – MD student

Miriam Michler-Abo Mustafa – MD student

Frederic Haydl – MD student
 
Data Management (Clinical Epidemiology)
Heidrun Lamparter (VTEval study)

Dr. Dagmar Laubert-Reh (GHS, CVSS)

 

Statistics (Clinical Epidemiology)
Andreas Schulz (GHS)

Markus Nagler (VTEval, CVSS) 

Guillin Wuise Kenmoe Tonlale – technical assistant

Original articles

• Ten Cate V, Nagler M, Panova-Noeva M, Eggebrecht L, Arnold N, Lamparter H, Hermanns MI, Ten Cate H, Prins MH, Espinola-Klein C, Münzel T, Lackner KJ, Wild PS, Prochaska JH. The diagnostic performance of renal function-adjusted D-dimer testing in individuals suspected of venous thromboembolism. Haematologica 2019.
• Eggebrecht L, Prochaska JH, Tröbs SO, Schwuchow-Thonke S, Göbel S, Diestelmeier S, Schulz A, Arnold N, Panova-Noeva M, Koeck T, Rapp S, Gori T, Lackner KJ, Ten Cate H, Münzel T, Wild PS. Direct oral anticoagulants and vitamin K antagonists are linked to differential profiles of cardiac function and lipid metabolism. Clin Res Cardiol 2019.
• Eggebrecht L, Nagler M, Göbel S, Lamparter H, Keller K, Wagner B, Panova-Noeva M, Ten Cate V, Bickel C, Lauterbach M, Espinola-Klein C, Hardt R, Münzel T, Prochaska JH, Wild PS. Relevance of Polypharmacy for Clinical Outcome in Patients Receiving Vitamin K Antagonists. J Am Geriatr Soc 2019;67(3):463-470.
• Burghardt J, Klein E, Brähler E, Ernst M, Schneider A, Eckerle S, Neu MA, Wingerter A, Henninger N, Panova‐Noeva M, Prochaska J, Wild P, Beutel M, Faber J. Prevalence of mental distress among adult survivors of childhood cancer in Germany—Compared to the general population. Cancer Medicine 2019;8(4):1865-1874.
• Panova-Noeva M, Neu MA, Eckerle S, Spix C, Schneider A, Schmidtmann I, Spronk HM, Pfeiffer N, Beutel M, Lackner KJ, Münzel T, Ten Cate H, Merzenich H, Faber J, Wild PS. Cardiovascular risk factors are important determinants of platelet-dependent thrombin generation in adult survivors of childhood cancer. Clin Res Cardiol 2019;108(4):438-447.
• Prochaska JH, Göbel S, Nagler M, Knöpfler T, Eggebrecht L, Lamparter H, Panova-Noeva M, Keller K, Coldewey M, Bickel C, Lauterbach M, Hardt R, Espinola-Klein C, Ten Cate H, Rostock T, Münzel T, Wild PS. Sustained atrial fibrillation increases the risk of anticoagulation-related bleeding in heart failure. Clin Res Cardiol 2018;107(12):1170-1179.
• Faber J, Wingerter A, Neu MA, Henninger N, Eckerle S, Münzel T, Lackner KJ, Beutel ME, Blettner M, Rathmann W, Peters A, Meisinger C, Linkohr B, Neuhauser H, Kaatsch P, Spix C, Schneider A, Merzenich H, Panova-Noeva M, Prochaska JH, Wild PS. Burden of cardiovascular risk factors and cardiovascular disease in childhood cancer survivors: data from the German CVSS-study. Eur Heart J 2018;39(17):1555-1562.
• Panova-Noeva M, Schulz A, Spronk HM, Beicht A, Laubert-Reh D, van Oerle R, Arnold N, Prochaska JH, Blettner M, Beutel M, Pfeiffer N, Münzel T, Lackner KJ, ten Cate H, Wild PS. Clinical determinants of thrombin generation measured in presence and absence of platelets – results from the Gutenberg Health Study. Thromb Haemost. 2018; 118(5):873-882.
• Panova-Noeva M, Schulz A, Arnold N, Hermanns IM, Prochaska JH, Laubert-Reh D, Spronk HM, Blettner M, Beutel M, Pfeiffer N, Münzel T, Lackner KJ, Ten Cate H, Wild PS. Coagulation and inflammation in long-term cancer survivors: results from the adult population. J Thromb Haemost. 2018 Feb 12. doi: 10.1111/jth.13975
• Prochaska JH, Frank B, Nagler M, Lamparter H, Weisser G, Schulz A, Eggebrecht L, Göbel S, Arnold N, Panova-Noeva M, Hermanns I, Pinto A, Konstantinides S, Ten Cate H, Lackner KJ, Münzel T, Espinola-Klein C, Wild PS (2017) Age-related diagnostic value of D-dimer testing and the role of inflammation in patients with suspected deep vein thrombosis. Scientific reports 7: 4591
• Panova-Noeva M, Arnold N, Hermanns MI, Prochaska J, Schulz A, Spronk HM, Binder H, Pfeiffer N, Beutel M, Blankenberg S, Zeller T, Lotz J, Münzel T, Lackner KJ, Ten Cate H, Wild PS. Mean platelet volume and arterial stiffness – clinical relationship and common genetic variability. Sci Rep. 2017 Jan 6;7:40229.
• Panova-Noeva M, Hermanns IM, Schulz A, Laubert-Reh D, Zeller T, Blankenberg S, Spronk HM, Münzel T, Lackner KJ, Ten Cate H, Wild PS. PO-58 - Cardiovascular risk profile in survivors of adult cancer - results from the general population study. Thromb Res. 2016 Apr;140 Suppl 1:S198.
• Panova-Noeva M, Schulz A, Hermanns MI, Grossmann V, Pefani E, Spronk HM, Laubert-Reh D, Binder H, Beutel M, Pfeiffer N, Blankenberg S, Zeller T, Münzel T, Lackner KJ, Ten Cate H, Wild PS. Sex-specific differences in genetic and nongenetic determinants of mean platelet volume: results from the Gutenberg Health Study. Blood. 2016 Jan 14;127(2):251-9.
• Grossmann V, Schmitt VH, Zeller T, Panova-Noeva M, Schulz A, Laubert-Reh D, Juenger C, Schnabel RB, Abt TG, Laskowski R, Wiltink J, Schulz E, Blankenberg S, Lackner KJ, Münzel T, Wild PS. Profile of the Immune and Inflammatory Response in Individuals With Prediabetes and Type 2 Diabetes. Diabetes Care. 2015 Jul;38(7):1356-64.
• Marchetti M, Tartari CJ, Russo L, Panova-Noeva M, Leuzzi A, Rambaldi A, Finazzi G, Woodhams B, Falanga A. Phospholipid-dependent procoagulant activity is highly expressed by circulating microparticles in patients with essential thrombocythemia. Am J Hematol. 2014 Jan;89(1):68-73.
• Panova-Noeva M, Marchetti M, Russo L, Tartari CJ, Leuzzi A, Finazzi G, Rambaldi A, ten Cate H, Falanga A. ADP-induced platelet aggregation and thrombin generation are increased in Essential Thrombocythemia and Polycythemia Vera. Thromb Res. 2013 Jul;132(1):88-93.
• Panova-Noeva M, Marchetti M, Buoro S, Russo L, Leuzzi A, Finazzi G, Rambaldi A, Ottomano C, Ten Cate H, Falanga A. JAK2V617F mutation and hydroxyurea treatment as determinants of immature platelet parameters in essential thrombocythemia and polycythemia vera patients. Blood. 2011 Sep 1;118(9):2599-601.
• Panova-Noeva M, Marchetti M, Spronk HM, Russo L, Diani E, Finazzi G, Salmoiraghi S, Rambaldi A, Barbui T, Ten Cate H, Falanga A. Platelet-induced thrombin generation by the calibrated automated thrombogram assay is increased in patients with essential thrombocythemia and polycythemia vera. Am J Hematol. 2011 Apr;86(4):337-42.
• Panova-Noeva M, Falanga A. Treatment of thromboembolism in cancer patients. Expert Opin Pharmacother. 2010 Aug;11(12):2049-58.
• Cella G, Marchetti M, Vianello F, Panova-Noeva M, Vignoli A, Russo L, Barbui T, Falanga A. Nitric oxide derivatives and soluble plasma selectins in patients with myeloproliferative neoplasms. Thromb Haemost. 2010 Jul;104(1):151-6.
• Spronk HM, Dielis AW, Panova-Noeva M, van Oerle R, Govers-Riemslag JW, Hamulyák K, Falanga A, Cate HT. Monitoring thrombin generation: is addition of corn trypsin inhibitor needed? Thromb Haemost. 2009 Jun;101(6):1156-62.
• Falanga A, Panova-Noeva M, Russo L. Procoagulant mechanisms in tumour cells. Best Pract Res Clin Haematol. 2009 Mar;22(1):49-60. 

Reviews

Panova-Noeva M, Eggebrecht L, Prochaska JH, Wild PS. Potential of Multidimensional, Large-scale Biodatabases to Elucidate Coagulation and Platelet Pathways as an Approach towards Precision Medicine in Thrombotic Disease. Hamostaseologie 2019.