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Prof. Dr. Ulrich Walter

(Scientific Director CTH until 09/2014)

Professor Ulrich Walter, MD
Professor Ulrich Walter, MD

Senior professor, Member of Leopoldina (ML), National Academy of Science

In January 2012 Prof. Walter joined the CTH as Professor for 'Translational Research in Thrombosis and Hemostasis' and Scientific Director. Prof. Walter is an expert in the field of Hemostasis and Thrombosis and nowadays supports the development of the CTH as Senior Professor.

Original articles

  • Zhang P, Solari FA, Heemskerk JWM, Kuijpers MJE, Sickmann A, Walter U,

    Jurk K. Differential Regulation of GPVI-Induced Btk and Syk Activation

    by PKC, PKA and PP2A in Human Platelets. Int J Mol Sci. 2023 Apr

    24;24(9):7776. doi: 10.3390/ijms24097776

  • Shpakova V, Rukoyatkina N, Walter U, Gambaryan S. Potential and limitations of PKA/ PKG inhibitors for platelet studies. Platelets. 2022 Aug 18;33(6):859-868
  • Kyselova A, Siragusa M, Anthes J, Solari FA, Loroch S, Zahedi RP, Walter U, Fleming I, Randriamboavonjy V. Cyclin Y is expressed in Platelets and Modulates Integrin Outside-in Signaling. Int J Mol Sci. 2020 Nov 3;21(21):8239



  • Makhoul S, Kumm E, Zhang P, Walter U, Jurk K. The Serine/Threonine Protein Phosphatase 2A (PP2A) Regulates Syk Activity in Human Platelets. Int J Mol Sci. 2020 Nov 25;21(23):8939
  • Comer S, Nagy Z, Bolado A, von Kriegsheim A, Gambaryan S, Walter U,

    Pagel O, Zahedi RP, Jurk K, Smolenski A. The RhoA regulators Myo9b and

    GEF-H1 are targets of cyclic nucleotide-dependent kinases in platelets. J Thromb Haemost. 2020 Nov;18(11):3002-3012



  • Döhrmann M, Makhoul S, Gross K, Krause M, Pillitteri D, von Auer C, Walter U, Lutz J, Volf I, Kehrel BE, Jurk K. CD36-fibrin interaction propagates FXI-dependent thrombin generation of human platelets. FASEB J. 2020 Jul;34(7):9337-9357



  • Kumm EJ, Pagel O, Gambaryan S, Walter U,

    Zahedi RP, Smolenski A, Jurk K. The Cell Cycle Checkpoint System

    MAST(L)-ENSA/ARPP19-PP2A is Targeted by cAMP/PKA and cGMP/PKG in

    Anucleate Human Platelets. Cells. 2020 Feb 18;9(2):472



  • Kiouptsi K, Finger S, Garlapati VS, Knorr M, Brandt M, Walter U,

    Wenzel P, Reinhardt C. Hypoxia evokes increased PDI and PDIA6

    expression in the infarcted myocardium of ex-germ-free and

    conventionally raised mice. Biol Open 2019;8(1)

  • Kiouptsi

    K, Jackel S, Pontarollo G, Grill A, Kuijpers MJE, Wilms E, Weber C,

    Sommer F, Nagy M, Neideck C, Jansen Y, Ascher S, Formes H, Karwot C,

    Bayer F, Kollar B, Subramaniam S, Molitor M, Wenzel P, Rosenstiel P,

    Todorov H, Gerber S, Walter U, Jurk K, Heemskerk JWM, van der

    Vorst EPC, Doring Y and Reinhardt C. The Microbiota Promotes Arterial

    Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice. Mbio. 2019;10

  • Makhoul S, Trabold K, Gambaryan S, Tenzer S, Pillitteri D, Walter U

    and Jurk K. cAMP- and cGMP-elevating agents inhibit GPIb alpha-mediated

    aggregation but not GPIb alpha-stimulated Syk activation in human

    platelets. Cell Communication and Signaling. 2019;17

  • Trabold K, Makhoul S, Garnbaryan S, van Ryn J, Walter U and Jurk K. The Direct Thrombin Inhibitors Dabigatran and Lepirudin Inhibit GPIb alpha-Mediated Platelet Aggregation. Thrombosis and Haemostasis. 2019;119:916-929
  • Comer S, Nagy Z, Bolado A, von Kriegsheim A, Gambaryan S, Walter U,

    Pagel O, Zahedi RP, Jurk K and Smolenski A. The RhoA regulators Myo9b

    and GEF-H1 are targets of cyclic nucleotide-dependent kinases in

    platelets. Journal of Thrombosis and Haemostasis. 2020;18:3002-3012

  • Dohmann M, Makhoul S, Gross K, Krause M, Pillitteri D, von Auer C, Walter U, Lutz J, Volf I, Kehrel BE and Jurk K. CD36-fibrin interaction propagates FXI-dependent thrombin generation of human platelets. Faseb Journal
  • Kumm EJ, Pagel O, Gambaryan S, Walter U,

    Zahedi RP, Smolenski A and Jurk K. The Cell Cycle Checkpoint System

    MAST(L)-ENSA/ARPP19-PP2A is Targeted by cAMP/PKA and cGMP/PKG in

    Anucleate Human Platelets. Cells. 2020;9

  • Kyselova A, Siragusa M, Anthes J, Solari FA, Loroch S, Zahedi RP, Walter U, Fleming I and Randriamboavonjy V. Cyclin Y Is Expressed in Platelets and Modulates Integrin Outside-in Signaling. International Journal of Molecular Sciences. 2020;21
  • Makhoul S, Dorschel S, Gambaryan S, Walter U and Jurk K. Feedback Regulation of Syk by Protein Kinase C in Human Platelets. International Journal of Molecular Sciences. 2020;21
  • Makhoul S, Kumm E, Zhang PY, Walter U and Jurk K. The Serine/Threonine Protein Phosphatase 2A (PP2A) Regulates Syk Activity in Human Platelets. International Journal of Molecular Sciences. 2020;21
  • Schönfelder T, Brandt M, Kossmann S, Knopp T, Münzel T, Walter U,

    Karbach SH, Wenzel P. Lack of T-bet reduces monocytic interleukin-12

    formation and accelerates thrombus resolution in deep vein thrombosis. Sci Rep 2018;8(1):3013

  • Makhoul S, Walter E, Pagel O, Walter U,

    Sickmann A, Gambaryan S, Smolenski A, Zahedi RP, Jurk K. Effects of the

    NO/soluble guanylate cyclase/cGMP system on the functions of human

    platelets. Nitric Oxide 2018;76:71-80

  • Beck F,

    Geiger J, Gambaryan S, Solari FA, Dell'Aica M, Loroch S, Mattheij NJ,

    Mindukshev I, Potz O, Jurk K, Burkhart JM, Fufezan C, Heemskerk JW, Walter U,

    Zahedi RP, Sickmann A (2017) Temporal quantitative phosphoproteomics of

    ADP stimulation reveals novel central nodes in platelet activation and

    inhibition. Blood 129: e1-e12

  • Jäckel S, Kiouptsi K,

    Lillich M, Hendrikx T, Khandagale A, Kollar B, Hörmann N, Reiss C,

    Subramaniam S, Wilms E, Ebner K, Brühl MV, Rausch P, Baines JF,

    Haberichter S, Lämmle B, Binder CJ, Jurk K, Ruggeri ZM, Massberg S, Walter U,

    Ruf W, Reinhardt C (2017) Gut microbiota regulate hepatic von

    Willebrand factor synthesis and arterial thrombus formation via

    Toll-like receptor-2. Blood 130: 542-553

  • Kiouptsi K, Gambaryan S, Walter E, Walter U, Jurk K, Reinhardt C (2017) Hypoxia impairs agonist-induced integrin alphaIIbbeta3 activation and platelet aggregation. Scientific reports 7: 7621
  • Kossmann

    S, Lagrange J, Jäckel S, Jurk K, Ehlken M, Schönfelder T, Weihert Y,

    Knorr M, Brandt M, Xia N, Li H, Daiber A, Oelze M, Reinhardt C, Lackner

    K, Gruber A, Monia B, Karbach SH, Walter U, Ruggeri ZM, Renné T,

    Ruf W, Münzel T, Wenzel P (2017) Platelet-localized FXI promotes a

    vascular coagulation-inflammatory circuit in arterial hypertension. Sci Transl Med 9

  • Loroch S, Trabold K, Gambaryan S, Reiss C, Schwierczek K, Fleming I, Sickmann A, Behnisch W, Zieger B, Zahedi RP, Walter U,

    Jurk K (2017) Alterations of the platelet proteome in type I Glanzmann

    thrombasthenia caused by different homozygous delG frameshift mutations

    in ITGA2B. Thrombosis and haemostasis 117: 556-569

  • Rukoyatkina N, Butt E, Subramanian H, Nikolaev VO, Mindukshev I, Walter U,

    Gambaryan S, Benz PM (2017) Protein kinase A activation by the

    anti-cancer drugs ABT-737 and thymoquinone is caspase-3-dependent and

    correlates with platelet inhibition and apoptosis. Cell Death Dis 8: e2898

  • enz PM, Laban H, Zink J, Günther L, Walter U, Gambaryan S,

    Dib K (2016) Vasodilator-Stimulated Phosphoprotein (VASP)-dependent and

    -independent pathways regulate thrombin-induced activation of Rap1b in

    platelets. Cell Commun Signal 14: 21

  • Gambaryan S, Subramanian H, Kehrer L, Mindukshev I, Sudnitsyna J, Reiss C, Rukoyatkina N, Friebe A, Sharina I, Martin E, Walter U

    (2016) Erythrocytes do not activate purified and platelet soluble

    guanylate cyclases even in conditions favourable for NO synthesis. Cell Commun Signal 14: 16

  • Manukyan D, Müller-Calleja N, Jäckel S, Luchmann K, Monnikes R, Kiouptsi K, Reinhardt C, Jurk K, Walter U, Lackner KJ (2016) Cofactor-independent human antiphospholipid antibodies induce venous thrombosis in mice. Journal of thrombosis and haemostasis 14: 1011-20
  • Reiss C, Mindukshev I, Bischoff V, Subramanian H, Kehrer L, Friebe A, Stasch JP, Gambaryan S, Walter U. The sGC stimulator Riociguat inhibits platelet function in washed platelets but not in whole blood. British journal of pharmacology, 2015
  • Bollmann F, Jäckel S, Schmidtke L, Schrick K, Reinhardt C, Jurk K, Wu Z, Xia N, Li H, Erkel G, Walter U,

    Kleinert H, Pautz A. Anti-inflammatory and anti-thrombotic effects of

    the fungal metabolite galiellalactone in apolipoprotein e-deficient

    mice. PLoS One. 2015;10:e013040

  • Frank B, Ariza L, Lamparter H, Grossmann V, Prochaska JH, Ullmann A, Kindler F, Weisser G, Walter U, Lackner KJ, Espinola-Klein C, Münzel T, Konstantinides SV, Wild PS.

    Rationale and design of three observational, prospective cohort studies

    including biobanking to evaluate and improve diagnostics, management

    strategies and risk stratification in venous thromboembolism: The vteval

    project. BMJ Open. 2015;5:e008157

  • Prochaska JH, Gobel S, Keller K, Coldewey M, Ullmann A, Lamparter H, Junger C, Al-Bayati Z, Baer C, Walter U,

    Bickel C, Ten Cate H, Munzel T, Wild PS. Quality of oral

    anticoagulation with phenprocoumon in regular medical care and its

    potential for improvement in a telemedicine-based coagulation service

    inverted question mark results from the prospective, multi-center,

    observational cohort study thrombEVAL. BMC medicine. 13:14, 2015

  • Navdaev A, Subramanian H, Petunin A, Clemetson KJ, Gambaryan S, Walter U. Echicetin coated polystyrene beads: a novel tool to investigate GPIb-specific platelet activation and aggregation. PloS one 9:e93569, 2014
  • Hubertus K, Mischnik M, Timmer J, Herterich S, Mark R, Moulard M, Walter U,

    Geiger J. Reciprocal regulation of human platelet function by

    endogenous prostanoids and through multiple prostanoid receptors. European journal of pharmacology. 740C:15-27, 2014

  • Hörmann N, Brandao I, Jäckel S, Ens N, Lillich M, Walter U, Reinhardt C.

    Gut microbial colonization orchestrates TLR2 expression, signaling and

    epithelial proliferation in the small intestinal mucosa. PloS one. 9:e113080, 2014

  • Beck F, Geiger J, Gambaryan S, Veit J, Vaudel M, Nollau P, Kohlbacher O, Martens L, Walter U,

    Sickmann A, Zahedi RP. Time-resolved characterization of

    camp/pka-dependent signaling reveals that platelet inhibition is a

    concerted process involving multiple signaling pathways. Blood. 123:e1-e10, 2014

  • Tenzer S, Docter D, Kuharev J, Musyanovych A, Fetz V, Hecht R, Schlenk F, Fischer D, Kiouptsi K, Reinhardt C,

    Landfester K, Schild H, Maskos M, Knauer SK, Stauber RH. Rapid

    formation of plasma protein corona critically affects nanoparticle

    pathophysiology. Nature nanotechnology. 8:772-781, 2013

  • Subramanian H, Zahedi RP, Sickmann A, Walter U, Gambaryan S. Phosphorylation of caldag-gefi by protein kinase a prevents rap1b activation. J Thromb Haemost. 11:1574-1582, 2013.
  • Schweigel H, Geiger J, Beck F, Buhs S, Gerull H, Walter U,

    Sickmann A, Nollau P. Deciphering of adp-induced,

    phosphotyrosine-dependent signaling networks in human platelets by

    src-homology 2 region (sh2)-profiling. Proteomics. 13:1016-1027, 2013

  • Rukoyatkina N, Mindukshev I, Walter U,

    Gambaryan S. Dual role of the p38 mapk/cpla(2) pathway in the

    regulation of platelet apoptosis induced by abt-737 and strong platelet

    agonists. Cell Death Dis. 4, 2013

  • Mihlan S, Reiss C,

    Thalheimer P, Herterich S, Gaetzner S, Kremerskothen J, Pavenstadt HJ,

    Lewandrowski U, Sickmann A, Butt E. Nuclear import of lasp-1 is

    regulated by phosphorylation and dynamic protein-protein interactions. Oncogene. 32:2107-2113, 2013

  • Hausding M, Jurk K,

    Daub S, Kroller-Schon S, Stein J, Schwenk M, Oelze M, Mikhed Y,

    Kerahrodi JG, Kossmann S, Jansen T, Schulz E, Wenzel P, Reske-Kunz AB,

    Becker C, Munzel T, Grabbe S, Daiber A. Cd40l contributes to angiotensin

    ii-induced pro-thrombotic state, vascular inflammation, oxidative

    stress and endothelial dysfunction. Basic research in cardiology. 108:386, 2013

  • Hahne JC, Meyer SR, Gambaryan S, Walter U, Dietl J, Engel JB, Honig A. Immune escape of akt overexpressing ovarian cancer cells. Int J Oncol. 42:1630-1635, 2013
  • Grunewald TG, Willier S, Janik D, Unland R, Reiss C,

    da Costa OP, Buch T, Dirksen U, Richter GH, Neff F, Burdach S, Butt E.

    The zyxin-related protein thyroid receptor interacting protein 6 (trip6)

    is overexpressed in ewing's sarcoma and promotes migration, invasion

    and cell growth. Biology of the cell / under the auspices of the European Cell Biology Organization. 2013

  • Geiger J, Burkhart JM, Gambaryan S, Walter U, Sickmann A, Zahedi RP. Response: Platelet transcriptome and proteome--relation rather than correlation. Blood. 121:5257-5258, 2013
  • Gambaryan S, Subramanian H, Rukoyatkina N, Herterich S, Walter U. Soluble guanylyl cyclase is the only enzyme responsible for cyclic guanosine monophosphate synthesis in human platelets. Thromb Haemostasis. 109:973-975, 2013
  • Fehrmann C, Jurk K,

    Bertling A, Seidel G, Fegeler W, Kehrel BE, Peters G, Becker K,

    Heilmann C. Role for the fibrinogen-binding proteins coagulase and efb

    in the staphylococcus aureus-candida interaction. International journal of medical microbiology: IJMM. 303:230-238, 2013

  • Erdmann

    J, Stark K, Esslinger UB, Rumpf PM, Koesling D, de Wit C, Kaiser FJ,

    Braunholz D, Medack A, Fischer M, Zimmermann ME, Tennstedt S, Graf E,

    Eck S, Aherrahrou Z, Nahrstaedt J, Willenborg C, Bruse P, Braenne I,

    Nothen MM, Hofmann P, Braund PS, Mergia E, Reinhard W, Burgdorf C,

    Schreiber S, Balmforth AJ, Hall AS, Bertram L, Steinhagen-Thiessen E, Li

    SC, Marz W, Reilly M, Kathiresan S, McPherson R, Walter U, Ott

    J, Samani NJ, Strom TM, Meitinger T, Hengstenberg C, Schunkert H,

    Assimes TL, Deloukas P, Holm H, Konig IR, Roberts R, Stewart AF.

    Dysfunctional nitric oxide signalling increases risk of myocardial

    infarction. Nature. 504:432-436, 2013

  • Brandt M, Schonfelder T, Schwenk M, Becker C, Jackel S, Reinhardt C,

    Stark K, Massberg S, Munzel T, von Bruhl ML, Wenzel P. Deep vein

    thrombus formation induced by flow reduction in mice is determined by

    venous side branches. Clinical hemorheology and microcirculation. 2013

  • Begonja AJ, Gambaryan S, Schulze H, Patel-Hett S, Italiano JE, Hartwig JH, Walter U. Differential roles of camp and cgmp in megakaryocyte maturation and platelet biogenesis. Exp Hematol. 41:91-101, 2013
  • Anaraki PK, Patecki M, Larmann J, Tkachuk S, Jurk K,

    Haller H, Theilmeier G, Dumler I. Urokinase receptor mediates

    osteogenic differentiation of mesenchymal stem cells and vascular

    calcification via the complement c5a receptor. Stem cells and development. 2013

  • Subramanian H, Gambaryan S, Panzer S, Gremmel T, Walter U, Mannhalter C. The thr715pro variant impairs terminal glycosylation of p-selectin. Thromb Haemostasis. 108:963-972, 2012
  • Sturm JB, Hess M, Weibel S, Chen NG, Yu YA, Zhang Q, Donat U, Reiss C,

    Gambaryan S, Krohne G, Stritzker J, Szalay AA. Functional hyper-il-6

    from vaccinia virus-colonized tumors triggers platelet formation and

    helps to alleviate toxicity of mitomycin c enhanced virus therapy. Journal of translational medicine. 10:9, 2012

  • Reinhardt C,

    Bergentall M, Greiner TU, Schaffner F, Ostergren-Lunden G, Petersen LC,

    Ruf W, Backhed F. Tissue factor and par1 promote microbiota-induced

    intestinal vascular remodelling. Nature. 483:627-631, 2012

  • Mindukshev I, Gambaryan S, Kehrer L, Schuetz C, Kobsar A, Rukoyatkina N, Nikolaev VO, Krivchenko A, Watson SP, Walter U, Geiger

    J. Low angle light scattering analysis: A novel quantitative method for

    functional characterization of human and murine platelet receptors. Clin Chem Lab Med. 50:1253-1262, 2012

  • Kobsar A, Koessler J, Kehrer L, Gambaryan S, Walter U.

    The thrombin inhibitors hirudin and refludan (r) activate the soluble

    guanylyl cyclase and the cgmp pathway in washed human platelets. Thromb Haemostasis. 107:521-529, 2012

  • Horn M, Bertling A, Brodde MF, Muller A, Roth J, Van Aken H, Jurk K,

    Heilmann C, Peters G, Kehrel BE. Human neutrophil alpha-defensins

    induce formation of fibrinogen and thrombospondin-1 amyloid-like

    structures and activate platelets via glycoprotein iib/iiia. J Thromb Haemost. 10:647-661, 2012.

  • Hahne JC, Honig A, Meyer SR, Gambaryan S, Walter U,

    Wischhusen J, Haussler SFM, Segerer SE, Fujita N, Dietl J, Engel JB.

    Downregulation of akt reverses platinum resistance of human ovarian

    cancers in vitro. Oncol Rep. 28:2023-2028, 2012.

  • Gambaryan S, Friebe A, Walter U. Does the no/sgc/cgmp/pkg pathway play a stimulatory role in platelets? Blood. 119:5335-5336, 2012.
  • Gambaryan S, Butt E, Kobsar A, Geiger J, Rukoyatkina N, Parnova R, Nikolaev VO, Walter U. The oligopeptide dt-2 is a specific pkg i inhibitor only in vitro, not in living cells. Brit J Pharmacol. 167:826-838, 2012.
  • Caesar R, Reigstad CS, Backhed HK, Reinhardt C,

    Ketonen M, Lunden GO, Cani PD, Backhed F. Gut-derived

    lipopolysaccharide augments adipose macrophage accumulation but is not

    essential for impaired glucose or insulin tolerance in mice. Gut. 61:1701-1707, 2012.

  • Burkhart JM, Vaudel M, Gambaryan S, Radau S, Walter U,

    Martens L, Geiger J, Sickmann A, Zahedi RP. The first comprehensive and

    quantitative analysis of human platelet protein composition allows the

    comparative analysis of structural and functional pathways. Blood. 120:E73-E82, 2012.

  • Bertling A, Niemann S, Hussain M, Holbrook L, Stanley RG, Brodde MF, Pohl S, Schifferdecker T, Roth J, Jurk K,

    Muller A, Lahav J, Peters G, Heilmann C, Gibbins JM, Kehrel BE.

    Staphylococcal extracellular adherence protein induces platelet

    activation by stimulation of thiol isomerases. Arteriosclerosis, thrombosis, and vascular biology. 32:1979-1990, 2012.


  • Shiravand Y, Walter U, Jurk K. Fine-Tuning of Platelet Responses by Serine/Threonine Protein Kinases and Phosphatases-Just the Beginning. Hamostaseologie. 2021 Jun;41(3):206-216.
  • Jurk K, Walter U. New Insights into Platelet Signalling Pathways by Functional and Proteomic Approaches. Hamostaseologie 2018.
  • Lämmle B, Walter U. Pearls, guidelines & more. Hamostaseologie. 34:199, 2014.
  • Burkhart JM, Gambaryan S, Watson SP, Jurk K, Walter U, Sickmann A, Heemskerk JWM, Zahedi RP. What Can Proteomics Tell Us About Platelets?. Circulation Research. 114:1204-1219, 2014.