Prof. Dr. Ulrich Walter

(Scientific Director CTH until 09/2014)

Professor Ulrich Walter, MD

Funktionen:

Senior professor, Member of Leopoldina (ML), National Academy of Science

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In January 2012 Prof. Walter joined the CTH as Professor for 'Translational Research in Thrombosis and Hemostasis' and Scientific Director. Prof. Walter is an expert in the field of Hemostasis and Thrombosis and nowadays supports the development of the CTH as Senior Professor.
 

• CURRICULUM VITAE Prof. Ulrich Walter  (Pdf-file, 399,5 KB)

Original articles

• Zhang P, Solari FA, Heemskerk JWM, Kuijpers MJE, Sickmann A, Walter U,

  Jurk K. Differential Regulation of GPVI-Induced Btk and Syk Activation

  by PKC, PKA and PP2A in Human Platelets. Int J Mol Sci. 2023 Apr

  24;24(9):7776. doi: 10.3390/ijms24097776

• Shpakova V, Rukoyatkina N, Walter U, Gambaryan S. Potential and limitations of PKA/ PKG inhibitors for platelet studies. Platelets. 2022 Aug 18;33(6):859-868

• Kyselova A, Siragusa M, Anthes J, Solari FA, Loroch S, Zahedi RP, Walter U, Fleming I, Randriamboavonjy V. Cyclin Y is expressed in Platelets and Modulates Integrin Outside-in Signaling. Int J Mol Sci. 2020 Nov 3;21(21):8239

   

   

• Makhoul S, Kumm E, Zhang P, Walter U, Jurk K. The Serine/Threonine Protein Phosphatase 2A (PP2A) Regulates Syk Activity in Human Platelets. Int J Mol Sci. 2020 Nov 25;21(23):8939

• Comer S, Nagy Z, Bolado A, von Kriegsheim A, Gambaryan S, Walter U,

  Pagel O, Zahedi RP, Jurk K, Smolenski A. The RhoA regulators Myo9b and

  GEF-H1 are targets of cyclic nucleotide-dependent kinases in platelets. J Thromb Haemost. 2020 Nov;18(11):3002-3012

   

   

• Döhrmann M, Makhoul S, Gross K, Krause M, Pillitteri D, von Auer C, Walter U, Lutz J, Volf I, Kehrel BE, Jurk K. CD36-fibrin interaction propagates FXI-dependent thrombin generation of human platelets. FASEB J. 2020 Jul;34(7):9337-9357

   

   

• Kumm EJ, Pagel O, Gambaryan S, Walter U,

  Zahedi RP, Smolenski A, Jurk K. The Cell Cycle Checkpoint System

  MAST(L)-ENSA/ARPP19-PP2A is Targeted by cAMP/PKA and cGMP/PKG in

  Anucleate Human Platelets. Cells. 2020 Feb 18;9(2):472

   

   

• Kiouptsi K, Finger S, Garlapati VS, Knorr M, Brandt M, Walter U,

  Wenzel P, Reinhardt C. Hypoxia evokes increased PDI and PDIA6

  expression in the infarcted myocardium of ex-germ-free and

  conventionally raised mice. Biol Open 2019;8(1)

• Kiouptsi

  K, Jackel S, Pontarollo G, Grill A, Kuijpers MJE, Wilms E, Weber C,

  Sommer F, Nagy M, Neideck C, Jansen Y, Ascher S, Formes H, Karwot C,

  Bayer F, Kollar B, Subramaniam S, Molitor M, Wenzel P, Rosenstiel P,

  Todorov H, Gerber S, Walter U, Jurk K, Heemskerk JWM, van der

  Vorst EPC, Doring Y and Reinhardt C. The Microbiota Promotes Arterial

  Thrombosis in Low-Density Lipoprotein Receptor-Deficient Mice. Mbio. 2019;10

• Makhoul S, Trabold K, Gambaryan S, Tenzer S, Pillitteri D, Walter U

  and Jurk K. cAMP- and cGMP-elevating agents inhibit GPIb alpha-mediated

  aggregation but not GPIb alpha-stimulated Syk activation in human

  platelets. Cell Communication and Signaling. 2019;17

• Trabold K, Makhoul S, Garnbaryan S, van Ryn J, Walter U and Jurk K. The Direct Thrombin Inhibitors Dabigatran and Lepirudin Inhibit GPIb alpha-Mediated Platelet Aggregation. Thrombosis and Haemostasis. 2019;119:916-929
• Comer S, Nagy Z, Bolado A, von Kriegsheim A, Gambaryan S, Walter U,

  Pagel O, Zahedi RP, Jurk K and Smolenski A. The RhoA regulators Myo9b

  and GEF-H1 are targets of cyclic nucleotide-dependent kinases in

  platelets. Journal of Thrombosis and Haemostasis. 2020;18:3002-3012

• Dohmann M, Makhoul S, Gross K, Krause M, Pillitteri D, von Auer C, Walter U, Lutz J, Volf I, Kehrel BE and Jurk K. CD36-fibrin interaction propagates FXI-dependent thrombin generation of human platelets. Faseb Journal
• Kumm EJ, Pagel O, Gambaryan S, Walter U,

  Zahedi RP, Smolenski A and Jurk K. The Cell Cycle Checkpoint System

  MAST(L)-ENSA/ARPP19-PP2A is Targeted by cAMP/PKA and cGMP/PKG in

  Anucleate Human Platelets. Cells. 2020;9

• Kyselova A, Siragusa M, Anthes J, Solari FA, Loroch S, Zahedi RP, Walter U, Fleming I and Randriamboavonjy V. Cyclin Y Is Expressed in Platelets and Modulates Integrin Outside-in Signaling. International Journal of Molecular Sciences. 2020;21
• Makhoul S, Dorschel S, Gambaryan S, Walter U and Jurk K. Feedback Regulation of Syk by Protein Kinase C in Human Platelets. International Journal of Molecular Sciences. 2020;21
• Makhoul S, Kumm E, Zhang PY, Walter U and Jurk K. The Serine/Threonine Protein Phosphatase 2A (PP2A) Regulates Syk Activity in Human Platelets. International Journal of Molecular Sciences. 2020;21
• Schönfelder T, Brandt M, Kossmann S, Knopp T, Münzel T, Walter U,

  Karbach SH, Wenzel P. Lack of T-bet reduces monocytic interleukin-12

  formation and accelerates thrombus resolution in deep vein thrombosis. Sci Rep 2018;8(1):3013

• Makhoul S, Walter E, Pagel O, Walter U,

  Sickmann A, Gambaryan S, Smolenski A, Zahedi RP, Jurk K. Effects of the

  NO/soluble guanylate cyclase/cGMP system on the functions of human

  platelets. Nitric Oxide 2018;76:71-80

• Beck F,

  Geiger J, Gambaryan S, Solari FA, Dell'Aica M, Loroch S, Mattheij NJ,

  Mindukshev I, Potz O, Jurk K, Burkhart JM, Fufezan C, Heemskerk JW, Walter U,

  Zahedi RP, Sickmann A (2017) Temporal quantitative phosphoproteomics of

  ADP stimulation reveals novel central nodes in platelet activation and

  inhibition. Blood 129: e1-e12

• Jäckel S, Kiouptsi K,

  Lillich M, Hendrikx T, Khandagale A, Kollar B, Hörmann N, Reiss C,

  Subramaniam S, Wilms E, Ebner K, Brühl MV, Rausch P, Baines JF,

  Haberichter S, Lämmle B, Binder CJ, Jurk K, Ruggeri ZM, Massberg S, Walter U,

  Ruf W, Reinhardt C (2017) Gut microbiota regulate hepatic von

  Willebrand factor synthesis and arterial thrombus formation via

  Toll-like receptor-2. Blood 130: 542-553

• Kiouptsi K, Gambaryan S, Walter E, Walter U, Jurk K, Reinhardt C (2017) Hypoxia impairs agonist-induced integrin alphaIIbbeta3 activation and platelet aggregation. Scientific reports 7: 7621
• Kossmann

  S, Lagrange J, Jäckel S, Jurk K, Ehlken M, Schönfelder T, Weihert Y,

  Knorr M, Brandt M, Xia N, Li H, Daiber A, Oelze M, Reinhardt C, Lackner

  K, Gruber A, Monia B, Karbach SH, Walter U, Ruggeri ZM, Renné T,

  Ruf W, Münzel T, Wenzel P (2017) Platelet-localized FXI promotes a

  vascular coagulation-inflammatory circuit in arterial hypertension. Sci Transl Med 9

• Loroch S, Trabold K, Gambaryan S, Reiss C, Schwierczek K, Fleming I, Sickmann A, Behnisch W, Zieger B, Zahedi RP, Walter U,

  Jurk K (2017) Alterations of the platelet proteome in type I Glanzmann

  thrombasthenia caused by different homozygous delG frameshift mutations

  in ITGA2B. Thrombosis and haemostasis 117: 556-569

• Rukoyatkina N, Butt E, Subramanian H, Nikolaev VO, Mindukshev I, Walter U,

  Gambaryan S, Benz PM (2017) Protein kinase A activation by the

  anti-cancer drugs ABT-737 and thymoquinone is caspase-3-dependent and

  correlates with platelet inhibition and apoptosis. Cell Death Dis 8: e2898

• enz PM, Laban H, Zink J, Günther L, Walter U, Gambaryan S,

  Dib K (2016) Vasodilator-Stimulated Phosphoprotein (VASP)-dependent and

  -independent pathways regulate thrombin-induced activation of Rap1b in

  platelets. Cell Commun Signal 14: 21

• Gambaryan S, Subramanian H, Kehrer L, Mindukshev I, Sudnitsyna J, Reiss C, Rukoyatkina N, Friebe A, Sharina I, Martin E, Walter U

  (2016) Erythrocytes do not activate purified and platelet soluble

  guanylate cyclases even in conditions favourable for NO synthesis. Cell Commun Signal 14: 16

• Manukyan D, Müller-Calleja N, Jäckel S, Luchmann K, Monnikes R, Kiouptsi K, Reinhardt C, Jurk K, Walter U, Lackner KJ (2016) Cofactor-independent human antiphospholipid antibodies induce venous thrombosis in mice. Journal of thrombosis and haemostasis 14: 1011-20
• Reiss C, Mindukshev I, Bischoff V, Subramanian H, Kehrer L, Friebe A, Stasch JP, Gambaryan S, Walter U. The sGC stimulator Riociguat inhibits platelet function in washed platelets but not in whole blood. British journal of pharmacology, 2015
• Bollmann F, Jäckel S, Schmidtke L, Schrick K, Reinhardt C, Jurk K, Wu Z, Xia N, Li H, Erkel G, Walter U,

  Kleinert H, Pautz A. Anti-inflammatory and anti-thrombotic effects of

  the fungal metabolite galiellalactone in apolipoprotein e-deficient

  mice. PLoS One. 2015;10:e013040

• Frank B, Ariza L, Lamparter H, Grossmann V, Prochaska JH, Ullmann A, Kindler F, Weisser G, Walter U, Lackner KJ, Espinola-Klein C, Münzel T, Konstantinides SV, Wild PS.

  Rationale and design of three observational, prospective cohort studies

  including biobanking to evaluate and improve diagnostics, management

  strategies and risk stratification in venous thromboembolism: The vteval

  project. BMJ Open. 2015;5:e008157

• Prochaska JH, Gobel S, Keller K, Coldewey M, Ullmann A, Lamparter H, Junger C, Al-Bayati Z, Baer C, Walter U,

  Bickel C, Ten Cate H, Munzel T, Wild PS. Quality of oral

  anticoagulation with phenprocoumon in regular medical care and its

  potential for improvement in a telemedicine-based coagulation service

  inverted question mark results from the prospective, multi-center,

  observational cohort study thrombEVAL. BMC medicine. 13:14, 2015

• Navdaev A, Subramanian H, Petunin A, Clemetson KJ, Gambaryan S, Walter U. Echicetin coated polystyrene beads: a novel tool to investigate GPIb-specific platelet activation and aggregation. PloS one 9:e93569, 2014
• Hubertus K, Mischnik M, Timmer J, Herterich S, Mark R, Moulard M, Walter U,

  Geiger J. Reciprocal regulation of human platelet function by

  endogenous prostanoids and through multiple prostanoid receptors. European journal of pharmacology. 740C:15-27, 2014

• Hörmann N, Brandao I, Jäckel S, Ens N, Lillich M, Walter U, Reinhardt C.

  Gut microbial colonization orchestrates TLR2 expression, signaling and

  epithelial proliferation in the small intestinal mucosa. PloS one. 9:e113080, 2014

• Beck F, Geiger J, Gambaryan S, Veit J, Vaudel M, Nollau P, Kohlbacher O, Martens L, Walter U,

  Sickmann A, Zahedi RP. Time-resolved characterization of

  camp/pka-dependent signaling reveals that platelet inhibition is a

  concerted process involving multiple signaling pathways. Blood. 123:e1-e10, 2014

• Tenzer S, Docter D, Kuharev J, Musyanovych A, Fetz V, Hecht R, Schlenk F, Fischer D, Kiouptsi K, Reinhardt C,

  Landfester K, Schild H, Maskos M, Knauer SK, Stauber RH. Rapid

  formation of plasma protein corona critically affects nanoparticle

  pathophysiology. Nature nanotechnology. 8:772-781, 2013

• Subramanian H, Zahedi RP, Sickmann A, Walter U, Gambaryan S. Phosphorylation of caldag-gefi by protein kinase a prevents rap1b activation. J Thromb Haemost. 11:1574-1582, 2013.
• Schweigel H, Geiger J, Beck F, Buhs S, Gerull H, Walter U,

  Sickmann A, Nollau P. Deciphering of adp-induced,

  phosphotyrosine-dependent signaling networks in human platelets by

  src-homology 2 region (sh2)-profiling. Proteomics. 13:1016-1027, 2013

• Rukoyatkina N, Mindukshev I, Walter U,

  Gambaryan S. Dual role of the p38 mapk/cpla(2) pathway in the

  regulation of platelet apoptosis induced by abt-737 and strong platelet

  agonists. Cell Death Dis. 4, 2013

• Mihlan S, Reiss C,

  Thalheimer P, Herterich S, Gaetzner S, Kremerskothen J, Pavenstadt HJ,

  Lewandrowski U, Sickmann A, Butt E. Nuclear import of lasp-1 is

  regulated by phosphorylation and dynamic protein-protein interactions. Oncogene. 32:2107-2113, 2013

• Hausding M, Jurk K,

  Daub S, Kroller-Schon S, Stein J, Schwenk M, Oelze M, Mikhed Y,

  Kerahrodi JG, Kossmann S, Jansen T, Schulz E, Wenzel P, Reske-Kunz AB,

  Becker C, Munzel T, Grabbe S, Daiber A. Cd40l contributes to angiotensin

  ii-induced pro-thrombotic state, vascular inflammation, oxidative

  stress and endothelial dysfunction. Basic research in cardiology. 108:386, 2013

• Hahne JC, Meyer SR, Gambaryan S, Walter U, Dietl J, Engel JB, Honig A. Immune escape of akt overexpressing ovarian cancer cells. Int J Oncol. 42:1630-1635, 2013
• Grunewald TG, Willier S, Janik D, Unland R, Reiss C,

  da Costa OP, Buch T, Dirksen U, Richter GH, Neff F, Burdach S, Butt E.

  The zyxin-related protein thyroid receptor interacting protein 6 (trip6)

  is overexpressed in ewing's sarcoma and promotes migration, invasion

  and cell growth. Biology of the cell / under the auspices of the European Cell Biology Organization. 2013

• Geiger J, Burkhart JM, Gambaryan S, Walter U, Sickmann A, Zahedi RP. Response: Platelet transcriptome and proteome--relation rather than correlation. Blood. 121:5257-5258, 2013
• Gambaryan S, Subramanian H, Rukoyatkina N, Herterich S, Walter U. Soluble guanylyl cyclase is the only enzyme responsible for cyclic guanosine monophosphate synthesis in human platelets. Thromb Haemostasis. 109:973-975, 2013
• Fehrmann C, Jurk K,

  Bertling A, Seidel G, Fegeler W, Kehrel BE, Peters G, Becker K,

  Heilmann C. Role for the fibrinogen-binding proteins coagulase and efb

  in the staphylococcus aureus-candida interaction. International journal of medical microbiology: IJMM. 303:230-238, 2013

• Erdmann

  J, Stark K, Esslinger UB, Rumpf PM, Koesling D, de Wit C, Kaiser FJ,

  Braunholz D, Medack A, Fischer M, Zimmermann ME, Tennstedt S, Graf E,

  Eck S, Aherrahrou Z, Nahrstaedt J, Willenborg C, Bruse P, Braenne I,

  Nothen MM, Hofmann P, Braund PS, Mergia E, Reinhard W, Burgdorf C,

  Schreiber S, Balmforth AJ, Hall AS, Bertram L, Steinhagen-Thiessen E, Li

  SC, Marz W, Reilly M, Kathiresan S, McPherson R, Walter U, Ott

  J, Samani NJ, Strom TM, Meitinger T, Hengstenberg C, Schunkert H,

  Assimes TL, Deloukas P, Holm H, Konig IR, Roberts R, Stewart AF.

  Dysfunctional nitric oxide signalling increases risk of myocardial

  infarction. Nature. 504:432-436, 2013

• Brandt M, Schonfelder T, Schwenk M, Becker C, Jackel S, Reinhardt C,

  Stark K, Massberg S, Munzel T, von Bruhl ML, Wenzel P. Deep vein

  thrombus formation induced by flow reduction in mice is determined by

  venous side branches. Clinical hemorheology and microcirculation. 2013

• Begonja AJ, Gambaryan S, Schulze H, Patel-Hett S, Italiano JE, Hartwig JH, Walter U. Differential roles of camp and cgmp in megakaryocyte maturation and platelet biogenesis. Exp Hematol. 41:91-101, 2013
• Anaraki PK, Patecki M, Larmann J, Tkachuk S, Jurk K,

  Haller H, Theilmeier G, Dumler I. Urokinase receptor mediates

  osteogenic differentiation of mesenchymal stem cells and vascular

  calcification via the complement c5a receptor. Stem cells and development. 2013

• Subramanian H, Gambaryan S, Panzer S, Gremmel T, Walter U, Mannhalter C. The thr715pro variant impairs terminal glycosylation of p-selectin. Thromb Haemostasis. 108:963-972, 2012
• Sturm JB, Hess M, Weibel S, Chen NG, Yu YA, Zhang Q, Donat U, Reiss C,

  Gambaryan S, Krohne G, Stritzker J, Szalay AA. Functional hyper-il-6

  from vaccinia virus-colonized tumors triggers platelet formation and

  helps to alleviate toxicity of mitomycin c enhanced virus therapy. Journal of translational medicine. 10:9, 2012

• Reinhardt C,

  Bergentall M, Greiner TU, Schaffner F, Ostergren-Lunden G, Petersen LC,

  Ruf W, Backhed F. Tissue factor and par1 promote microbiota-induced

  intestinal vascular remodelling. Nature. 483:627-631, 2012

• Mindukshev I, Gambaryan S, Kehrer L, Schuetz C, Kobsar A, Rukoyatkina N, Nikolaev VO, Krivchenko A, Watson SP, Walter U, Geiger

  J. Low angle light scattering analysis: A novel quantitative method for

  functional characterization of human and murine platelet receptors. Clin Chem Lab Med. 50:1253-1262, 2012

• Kobsar A, Koessler J, Kehrer L, Gambaryan S, Walter U.

  The thrombin inhibitors hirudin and refludan (r) activate the soluble

  guanylyl cyclase and the cgmp pathway in washed human platelets. Thromb Haemostasis. 107:521-529, 2012

• Horn M, Bertling A, Brodde MF, Muller A, Roth J, Van Aken H, Jurk K,

  Heilmann C, Peters G, Kehrel BE. Human neutrophil alpha-defensins

  induce formation of fibrinogen and thrombospondin-1 amyloid-like

  structures and activate platelets via glycoprotein iib/iiia. J Thromb Haemost. 10:647-661, 2012.

• Hahne JC, Honig A, Meyer SR, Gambaryan S, Walter U,

  Wischhusen J, Haussler SFM, Segerer SE, Fujita N, Dietl J, Engel JB.

  Downregulation of akt reverses platinum resistance of human ovarian

  cancers in vitro. Oncol Rep. 28:2023-2028, 2012.

• Gambaryan S, Friebe A, Walter U. Does the no/sgc/cgmp/pkg pathway play a stimulatory role in platelets? Blood. 119:5335-5336, 2012.
• Gambaryan S, Butt E, Kobsar A, Geiger J, Rukoyatkina N, Parnova R, Nikolaev VO, Walter U. The oligopeptide dt-2 is a specific pkg i inhibitor only in vitro, not in living cells. Brit J Pharmacol. 167:826-838, 2012.
• Caesar R, Reigstad CS, Backhed HK, Reinhardt C,

  Ketonen M, Lunden GO, Cani PD, Backhed F. Gut-derived

  lipopolysaccharide augments adipose macrophage accumulation but is not

  essential for impaired glucose or insulin tolerance in mice. Gut. 61:1701-1707, 2012.

• Burkhart JM, Vaudel M, Gambaryan S, Radau S, Walter U,

  Martens L, Geiger J, Sickmann A, Zahedi RP. The first comprehensive and

  quantitative analysis of human platelet protein composition allows the

  comparative analysis of structural and functional pathways. Blood. 120:E73-E82, 2012.

• Bertling A, Niemann S, Hussain M, Holbrook L, Stanley RG, Brodde MF, Pohl S, Schifferdecker T, Roth J, Jurk K,

  Muller A, Lahav J, Peters G, Heilmann C, Gibbins JM, Kehrel BE.

  Staphylococcal extracellular adherence protein induces platelet

  activation by stimulation of thiol isomerases. Arteriosclerosis, thrombosis, and vascular biology. 32:1979-1990, 2012.

Reviews

• Shiravand Y, Walter U, Jurk K. Fine-Tuning of Platelet Responses by Serine/Threonine Protein Kinases and Phosphatases-Just the Beginning. Hamostaseologie. 2021 Jun;41(3):206-216.
• Jurk K, Walter U. New Insights into Platelet Signalling Pathways by Functional and Proteomic Approaches. Hamostaseologie 2018.
• Lämmle B, Walter U. Pearls, guidelines & more. Hamostaseologie. 34:199, 2014.
• Burkhart JM, Gambaryan S, Watson SP, Jurk K, Walter U, Sickmann A, Heemskerk JWM, Zahedi RP. What Can Proteomics Tell Us About Platelets?. Circulation Research. 114:1204-1219, 2014.