Visual Universitätsmedizin Mainz

Infektionsimmunologie (Sparwasser Labor)

Aktuelle Forschung

Infektionskrankheiten stellen nach wie vor ein zentrales globales Gesundheitsproblem dar. In Europa sind Infektionen der unteren Atemwege, die zum Beispiel durch Streptococcus pneumoniae verursacht werden, eine der Hauptursachen für Morbidität und Mortalität, obwohl Impfstoffe gegen diesen Erreger zur Verfügung stehen. Darüber hinaus stellt die Zunahme von Infektionen mit multiresistenten Bakterien, z.B. Mycobacterium tuberculosis, eine ständige Bedrohung für unsere Gesellschaft dar. Unter dem Dach der Abteilung für Medizinische Mikrobiologie und Hygiene untersuchen Forscher um Univ.-Prof. Dr. Tim Sparwasser mehrere zentrale Aspekte der Infektionsbiologie. Dazu gehört ein besseres Verständnis der Wirt-Pathogen-Interaktionen und der Mechanismen, die die infektionsbedingte Immunantwort aktivieren und regulieren. Darüber hinaus erforschen die Wissenschaftler den genetischen Hintergrund und die molekularen Prozesse der infektionsassoziierten Immunantwort und sie suchen nach neuen Wegen, die Immunantwort zu modulieren. Das Ziel der Arbeiten ist es schließlich, die neuen Erkenntnisse der Grundlagenforschung in die klinische Anwendung zu übertragen.

 

Fortschritte in der modernen Medizin, insbesondere auf dem Gebiet der Transplantation und der Intensivmedizin, haben die Lebenserwartung in der westlichen Welt stark erhöht, führen aber auch zu einem Wiederauftreten opportunistischer (z.B. CMV und Candida) und im Krankenhaus erworbener (z.B. Clostridium difficile) Infektionen, die unser medizinisches System vor ernste Probleme stellen. Weitere Herausforderungen der alternden europäischen Gesellschaft sind Autoimmunität und Krebs. Die gemeinsame Ursache dieser Hauptherausforderungen liegt in eine unzureichenden T-Zell Immunantwort.

 

Impfungen gelten als eine der größten Erfolgsgeschichten in der Medizin und können langfristige Nachhaltigkeit und Effizienz garantieren. Die Identifizierung verbesserter Adjuvantien, insbesondere für die T-Zell-Immunität, würde eines der größten klinischen Probleme lösen. Neuartige Impfstoffe, insbesondere gegen weitgehend arzneimittelresistente Bakterien wie Mykobakterien, stellen nach wie vor eine große Herausforderung dar. Ein neuer Ansatz, bei dem nicht der Erreger selbst im Mittelpunkt steht, ist das Konzept der "Immunmodulation". Die Identifizierung und Charakterisierung von Stoffwechselprodukten der Mikrobiota zeigt, dass diese einen direkten Einfluss auf die Immunreaktion des Wirts haben, neue therapeutische Möglichkeiten zur Verkürzung der Antibiotikatherapie aufzeigen oder zur Verringerung der Immunpathologie bei Infektions- oder Entzündungskrankheiten beitragen.

Mitarbeiter

Univ.-Prof. Dr. med. Sparwasser
Univ.-Prof. Dr. med. Tim Sparwasser
Function: Principal Investigator

06131 17-9362
06131 17-9234
sparwasser@uni-mainz.de
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Dr. rer. nat. Breid
Dr. rer. nat. Sara Breid
Function: Scientific Manager

06131 17-9144
06131 17-9234
sara.breid@uni-mainz.de
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Platzhalterbild
Fatima Al-Naimi
Function: Ph.D. Student

06131 17-9011
06131 17-9234
falnaimi@uni-mainz.de
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Boukhallouk
Fatima Boukhallouk
Function: Medical Technician

06131 17-9011 office or 9082 lab
06131 17-9234
bouk@uni-mainz.de
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Braband
Kathrin Braband
Function: Ph.D. Student

06131 17-9011
06131 17-9234
kbraband@uni-mainz.de
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Gündüz
Basak Gündüz
Function: Ph.D. Student

06131 17-9234
bguendue@uni-mainz.de
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Kao
Yu-San Kao
Function: Ph.D. Student

06131 17-9011
06131 17-9234
yusankao@uni-mainz.de
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Lahrmann
Catharina Lahrmann
Function: Medical Technician

06131 17-9336
06131 17-9234
clahrman@uni-mainz.de

Mamareli
Panagiota Mamareli
Function: Postdoc

06131 17-9011 office or 9082 lab
06131 17-9234
pmamarel@uni-mainz.de
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Publikationen

2021

Carriche Guilhermina M., Almeida Luis, Stuve Philipp, Velasquez Lis, Dhillon-LaBrooy Ayesha, Roy Urmi, Lindenberg Marc, Strowig Till, Plaza-Sirvent Carlos, Schmitz Ingo, Lochner Matthias, Simon Anna Katharina, Sparwasser Tim (2021). Regulating T-cell differentiation through the polyamine spermidine. Journal of Allergy and Clinical Immunology 147 (1): 335-+

Almeida, L., A. Dhillon-LaBrooy, C.N. Castro, N. Adossa, G.M. Carriche, M. Guderian, S. Lippens, S. Dennerlein, C. Hesse, B.N. Lambrecht, L. Berod, L. Schauser, B.R. Blazar, M. Kalesse, R. Muller, L.F. Moita, and T. Sparwasser. (2021). Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis. Immunity 54:68-83 e66.

Korkmaz, Y., Puladi, B., Galler, K., Kammerer, P.W., Schroder, A., Golz, L., Sparwasser, T., Bloch, W., Friebe, A., and Deschner, J. (2021). Inflammation in the Human Periodontium Induces Downregulation of the alpha1- and beta1-Subunits of the sGC in Cementoclasts. Int J Mol Sci 22.

Lindenberg, M., L. Almeida, A. Dhillon-LaBrooy, E. Siegel, B. Henriques-Normark, and T. Sparwasser. 2021. Clarithromycin impairs tissue-resident memory and Th17 responses to macrolide-resistant Streptococcus pneumoniae infections. J Mol Med (Berl)

Minarrieta, L., Velasquez, L.N., Sparwasser, T., and Berod, L. (2021). Dendritic cell metabolism: moving beyond in vitro-culture-generated paradigms. Curr Opin Biotechnol 68, 202-212.


2020

Einwachter, H., Heiseke, A., Schlitzer, A., Gasteiger, G., Adler, H., Voehringer, D., Manz, M.G., Ruzsics, Z., Dolken, L., Koszinowski, U.H., et al. (2020). The Innate Immune Response to Infection Induces Erythropoietin-Dependent Replenishment of the Dendritic Cell Compartment. Front Immunol 11, 1627.

Gamrekelashvili, J., Kapanadze, T., Sablotny, S., Ratiu, C., Dastagir, K., Lochner, M., Karbach, S., Wenzel, P., Sitnow, A., Fleig, S., et al. (2020). Notch and TLR signaling coordinate monocyte cell fate and inflammation. Elife 9.

Haack, S., S. Baiker, J. Schlegel, M. Sauer, T. Sparwasser, D. Langenhorst, and N. Beyersdorf. 2020. Superagonistic CD28 stimulation induces Interferon gamma release from mouse T Helper 1 cells in vitro and in vivo. Eur J Immunol

Mamareli, P., F. Kruse, C.W. Lu, M. Guderian, S. Floess, K. Rox, D.S.J. Allan, J.R. Carlyle, M. Bronstrup, R. Muller, L. Berod, T. Sparwasser*, and M. Lochner*. 2020. Targeting cellular fatty acid synthesis limits T helper and innate lymphoid cell function during intestinal inflammation and infection. Mucosal Immunol. *equally contributed

Mesquita, I., C. Ferreira, D. Moreira, G.E.G. Kluck, A.M. Barbosa, E. Torrado, R.J. Dinis-Oliveira, L.G. Goncalves, C.J. Beauparlant, A. Droit, L. Berod, T. Sparwasser, N. Bodhale, B. Saha, F. Rodrigues, C. Cunha, A. Carvalho, A.G. Castro, J. Estaquier, and R. Silvestre. 2020. The Absence of HIF-1alpha Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis. Cell Rep 30:4052-4064 e4057.

Miyanaga, N., Takagi, H., Uto, T., Fukaya, T., Nasu, J., Fukui, T., Nishikawa, Y., Sparwasser, T., Choijookhuu, N., Hishikawa, Y., et al. (2020). Essential role of submandibular lymph node dendritic cells in protective sublingual immunotherapy against murine allergy. Commun Biol 3, 742.

Moye, S., T. Bormann, R. Maus, T. Sparwasser, I. Sandrock, I. Prinz, G. Warnecke, T. Welte, J. Gauldie, M. Kolb, and U.A. Maus. 2020. Regulatory T Cells Limit Pneumococcus-Induced Exacerbation of Lung Fibrosis in Mice. J Immunol 204:2429-2438.

Sacramento, L.A., L. Benevides, S.R. Maruyama, L. Tavares, K.F. Fukutani, M. Francozo, T. Sparwasser, F.Q. Cunha, R.P. Almeida, J.S. da Silva, and V. Carregaro. 2020. TLR4 abrogates the Th1 immune response through IRF1 and IFN-beta to prevent immunopathology during L. infantum infection. PLoS Pathog 16:e1008435.

 

2019

Ahmetlic, F., T. Riedel, N. Homberg, V. Bauer, N. Trautwein, A. Geishauser, T. Sparwasser, S. Stevanovic, M. Rocken, and R. Mocikat. 2019. Regulatory T Cells in an Endogenous Mouse Lymphoma Recognize Specific Antigen Peptides and Contribute to Immune Escape. Cancer Immunol Res 7:600-608.

Almeida, L., A. Dhillon-LaBrooy, C.N. Castro, N. Ayele, J. Bartel, G.M. Carriche, M. Guderian, S. Lippens, S. Dennerlein, C. Hesse, B.N. Lambrecht, L. Schauser, B.R. Blazar, M. Kalesse, R. Müller, L.F. Moita and T.Sparwasser. 2019. Ribosome-targeting antibiotics impair T cell effector function and ameliorate autoimmunity by blocking mitochondrial protein synthesis. BioRxiv 832956.

Al Nabhani, Z., S. Dulauroy, R. Marques, C. Cousu, S. Al Bounny, F. Dejardin, T. Sparwasser, M. Berard, N. Cerf-Bensussan, and G. Eberl. 2019. A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult. Immunity 50:1276-1288 e1275.

Andersen, L., A.F. Gulich, M. Alteneder, T. Preglej, M.J. Orola, N. Dhele, V. Stolz, A. Schebesta, P. Hamminger, A. Hladik, S. Floess, T. Krausgruber, T. Faux, S.B.A. Andrabi, J. Huehn, S. Knapp, T. Sparwasser, C. Bock, A. Laiho, L.L. Elo, O. Rasool, R. Lahesmaa, S. Sakaguchi, and W. Ellmeier. 2019. The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3(+) Regulatory T Cells. Cell Rep 29:4447-4459 e4446.

Ichikawa, T., K. Hirahara, K. Kokubo, M. Kiuchi, A. Aoki, Y. Morimoto, J. Kumagai, A. Onodera, N. Mato, D.J. Tumes, Y. Goto, K. Hagiwara, Y. Inagaki, T. Sparwasser, K. Tobe, and T. Nakayama. 2019. CD103(hi) Treg cells constrain lung fibrosis induced by CD103(lo) tissue-resident pathogenic CD4 T cells. Nat Immunol 20:1469-1480.

Mamareli, P., F. Kruse, C. Friedrich, N. Smit, T. Strowig, T. Sparwasser, and M. Lochner. 2019. Epithelium-specific MyD88 signaling, but not DCs or macrophages, control acute intestinal infection with Clostridium difficile. Eur J Immunol 49:747-757.

Schmidleithner, L., Y. Thabet, E. Schonfeld, M. Kohne, D. Sommer, Z. Abdullah, T. Sadlon, C. Osei-Sarpong, K. Subbaramaiah, F. Copperi, K. Haendler, T. Varga, O. Schanz, S. Bourry, K. Bassler, W. Krebs, A.E. Peters, A.K. Baumgart, M. Schneeweiss, K. Klee, S.V. Schmidt, S. Nussing, J. Sander, N. Ohkura, A. Waha, T. Sparwasser, F.T. Wunderlich, I. Forster, T. Ulas, H. Weighardt, S. Sakaguchi, A. Pfeifer, M. Bluher, A.J. Dannenberg, N. Ferreiros, L.J. Muglia, C. Wickenhauser, S.C. Barry, J.L. Schultze, and M. Beyer. 2019. Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction. Immunity 50:1232-1248 e1214.

Serradell, M.C., L.L. Rupil, R.A. Martino, C.G. Prucca, P.G. Carranza, A. Saura, E.A. Fernandez, P.R. Gargantini, A.H. Tenaglia, J.P. Petiti, R.R. Tonelli, N. Reinoso-Vizcaino, J. Echenique, L. Berod, E. Piaggio, B. Bellier, T. Sparwasser, D. Klatzmann, and H.D. Lujan. 2019. Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins. Nat Commun 10:361.

Solmaz, G., F. Puttur, M. Francozo, M. Lindenberg, M. Guderian, M. Swallow, V. Duhan, V. Khairnar, U. Kalinke, B. Ludewig, B.E. Clausen, H. Wagner, K.S. Lang, and T.D. Sparwasser. 2019. TLR7 Controls VSV Replication in CD169(+) SCS Macrophages and Associated Viral Neuroinvasion. Front Immunol 10:466.

Steel, N., A.A. Faniyi, S. Rahman, S. Swietlik, B.I. Czajkowska, B.T. Chan, A. Hardgrave, A. Steel, T.D. Sparwasser, M.B. Assas, R.K. Grencis, M.A. Travis, and J.J. Worthington. 2019. TGFbeta-activation by dendritic cells drives Th17 induction and intestinal contractility and augments the expulsion of the parasite Trichinella spiralis in mice. PLoS Pathog 15:e1007657.

Wang, Y., K. Dembowsky, E. Chevalier, P. Stuve, M. Korf-Klingebiel, M. Lochner, L.C. Napp, H. Frank, E. Brinkmann, A. Kanwischer, J. Bauersachs, M. Gyongyosi, T. Sparwasser, and K.C. Wollert. 2019. C-X-C Motif Chemokine Receptor 4 Blockade Promotes Tissue Repair After Myocardial Infarction by Enhancing Regulatory T Cell Mobilization and Immune-Regulatory Function. Circulation 139:1798-1812.

 

2018

Akeus, P., L. Szeponik, F. Ahlmanner, P. Sundstrom, S. Alsen, B. Gustavsson, T. Sparwasser, S. Raghavan, and M. Quiding-Jarbrink. 2018. Regulatory T cells control endothelial chemokine production and migration of T cells into intestinal tumors of APC(min/+) mice. Cancer Immunol Immunother 67:1067-1077.

Alissafi, T., E. Kourepini, D.C.M. Simoes, N. Paschalidis, M. Aggelakopoulou, T. Sparwasser, L. Boon, H. Hammad, B.N. Lambrecht, and V. Panoutsakopoulou. 2018. Osteopontin Promotes Protective Antigenic Tolerance against Experimental Allergic Airway Disease. J Immunol 200:1270-1282.

Andreas, N., M. Riemann, C.N. Castro, M. Groth, I. Koliesnik, C. Engelmann, T. Sparwasser, T. Kamradt, R. Haenold, and F. Weih. 2018. A new RelB-dependent CD117(+) CD172a(+) murine DC subset preferentially induces Th2 differentiation and supports airway hyperresponses in vivo. Eur J Immunol 48:923-936.

Divakaruni, A.S., W.Y. Hsieh, L. Minarrieta, T.N. Duong, K.K.O. Kim, B.R. Desousa, A.Y. Andreyev, C.E. Bowman, K. Caradonna, B.P. Dranka, D.A. Ferrick, M. Liesa, L. Stiles, G.W. Rogers, D. Braas, T.P. Ciaraldi, M.J. Wolfgang, T. Sparwasser, L. Berod, S.J. Bensinger, and A.N. Murphy. 2018. Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis. Cell Metab 28:490-503 e497.

Paul-Heng, M., M. Leong, E. Cunningham, D.L.J. Bunker, K. Bremner, Z. Wang, C. Wang, S.S. Tay, C. McGuffog, G.J. Logan, I.E. Alexander, M. Hu, S.I. Alexander, T.D. Sparwasser, P. Bertolino, D.G. Bowen, G.A. Bishop, and A. Sharland. 2018. Direct recognition of hepatocyte-expressed MHC class I alloantigens is required for tolerance induction. JCI Insight 3:

Raud, B., P.J. McGuire, R.G. Jones, T. Sparwasser, and L. Berod. 2018. Fatty acid metabolism in CD8(+) T cell memory: Challenging current concepts. Immunol Rev 283:213-231.

Raud, B., D.G. Roy, A.S. Divakaruni, T.N. Tarasenko, R. Franke, E.H. Ma, B. Samborska, W.Y. Hsieh, A.H. Wong, P. Stuve, C. Arnold-Schrauf, M. Guderian, M. Lochner, S. Rampertaap, K. Romito, J. Monsale, M. Bronstrup, S.J. Bensinger, A.N. Murphy, P.J. McGuire, R.G. Jones, T. Sparwasser*, and L. Berod*. 2018. Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation. Cell Metab 28:504-515 e507.*equally contributed

Semitekolou, M., I. Morianos, A. Banos, D. Konstantopoulos, M. Adamou-Tzani, T. Sparwasser, and G. Xanthou. 2018. Dendritic cells conditioned by activin A-induced regulatory T cells exhibit enhanced tolerogenic properties and protect against experimental asthma. J Allergy Clin Immunol 141:671-684 e677.

Serradell, M.C., P.R. Gargantini, A. Saura, S.R. Oms, L.L. Rupil, L. Berod, T. Sparwasser, and H.D. Lujan. 2018. Cytokines, Antibodies, and Histopathological Profiles during Giardia Infection and Variant-Specific Surface Protein-Based Vaccination. Infect Immun 86:

Singpiel, A., J. Kramer, R. Maus, J. Stolper, L.F. Bittersohl, J. Gauldie, M. Kolb, T. Welte, T. Sparwasser, and U.A. Maus. 2018. Adenoviral vector-mediated GM-CSF gene transfer improves anti-mycobacterial immunity in mice - role of regulatory T cells. Immunobiology 223:331-341.

Stuve, P., L. Minarrieta, H. Erdmann, C. Arnold-Schrauf, M. Swallow, M. Guderian, F. Krull, A. Holscher, P. Ghorbani, J. Behrends, W.R. Abraham, C. Holscher, T.D. Sparwasser, and L. Berod. 2018. De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages. Front Immunol 9:495.

Velasquez, L.N., P. Stuve, M.V. Gentilini, M. Swallow, J. Bartel, N.Y. Lycke, D. Barkan, M. Martina, H.D. Lujan, H. Kalay, Y. van Kooyk, T.D. Sparwasser, and L. Berod. 2018. Targeting Mycobacterium tuberculosis Antigens to Dendritic Cells via the DC-Specific-ICAM3-Grabbing-Nonintegrin Receptor Induces Strong T-Helper 1 Immune Responses. Front Immunol 9:471.

 

2017

Alissafi, T., A. Banos, L. Boon, T. Sparwasser, A. Ghigo, K. Wing, D. Vassilopoulos, D. Boumpas, T. Chavakis, K. Cadwell, and P. Verginis. 2017. Tregs restrain dendritic cell autophagy to ameliorate autoimmunity. J Clin Invest 127:2789-2804.

Bieber, K., S. Sun, M. Witte, A. Kasprick, F. Beltsiou, M. Behnen, T. Laskay, F.S. Schulze, E. Pipi, N. Reichhelm, R. Pagel, D. Zillikens, E. Schmidt, T. Sparwasser, K. Kalies, and R.J. Ludwig. 2017. Regulatory T Cells Suppress Inflammation and Blistering in Pemphigoid Diseases. Front Immunol 8:1628.

Friedrich, C., P. Mamareli, S. Thiemann, F. Kruse, Z. Wang, B. Holzmann, T. Strowig, T. Sparwasser*, and M. Lochner*. 2017. MyD88 signaling in dendritic cells and the intestinal epithelium controls immunity against intestinal infection with C. rodentium. PLoS Pathog 13:e1006357. *equally contributed

Minarrieta, L., P. Ghorbani, T. Sparwasser, and L. Berod. 2017. Metabolites: deciphering the molecular language between DCs and their environment. Semin Immunopathol 39:177-198.

Popovic, B., M. Golemac, J. Podlech, J. Zeleznjak, L. Bilic-Zulle, M.L. Lukic, L. Cicin-Sain, M.J. Reddehase, T. Sparwasser, A. Krmpotic, and S. Jonjic. 2017. IL-33/ST2 pathway drives regulatory T cell dependent suppression of liver damage upon cytomegalovirus infection. PLoS Pathog 13:e1006345.

van der Vlugt, L., K. Obieglo, A. Ozir-Fazalalikhan, T. Sparwasser, S. Haeberlein, and H.H. Smits. 2017. Schistosome-induced pulmonary B cells inhibit allergic airway inflammation and display a reduced Th2-driving function. Int J Parasitol 47:545-554.

Zischke, J., P. Mamareli, C. Pokoyski, I. Gabaev, S. Buyny, R. Jacobs, C.S. Falk, M. Lochner, T. Sparwasser, T.F. Schulz, and P.C. Kay-Fedorov. 2017. The human cytomegalovirus glycoprotein pUL11 acts via CD45 to induce T cell IL-10 secretion. PLoS Pathog 13:e1006454.

 

2016

Almeida, L., M. Lochner, L. Berod, and T. Sparwasser. 2016. Metabolic pathways in T cell activation and lineage differentiation. Semin Immunol 28:514-524.

Dudek, M., F. Puttur, C. Arnold-Schrauf, A.A. Kuhl, B. Holzmann, B. Henriques-Normark, L. Berod, and T. Sparwasser. 2016. Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection. Mucosal Immunol 9:1288-1302.

Freitag, J., L. Berod, T. Kamradt, and T. Sparwasser. 2016. Immunometabolism and autoimmunity. Immunol Cell Biol 94:925-934.

Knuschke, T., O. Rotan, W. Bayer, V. Sokolova, W. Hansen, T. Sparwasser, U. Dittmer, M. Epple, J. Buer, and A.M. Westendorf. 2016. Combination of nanoparticle-based therapeutic vaccination and transient ablation of regulatory T cells enhances anti-viral immunity during chronic retroviral infection. Retrovirology 13:24.

Mykicki, N., A.M. Herrmann, N. Schwab, R. Deenen, T. Sparwasser, A. Limmer, L. Wachsmuth, L. Klotz, K. Kohrer, C. Faber, H. Wiendl, T.A. Luger, S.G. Meuth, and K. Loser. 2016. Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease. Sci Transl Med 8:362ra146.

Navarro, S., D.A. Pickering, I.B. Ferreira, L. Jones, S. Ryan, S. Troy, A. Leech, P.J. Hotez, B. Zhan, T. Laha, R. Prentice, T. Sparwasser, J. Croese, C.R. Engwerda, J.W. Upham, V. Julia, P.R. Giacomin, and A. Loukas. 2016. Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma. Sci Transl Med 8:362ra143.

Perdicchio, M., J.M. Ilarregui, M.I. Verstege, L.A. Cornelissen, S.T. Schetters, S. Engels, M. Ambrosini, H. Kalay, H. Veninga, J.M. den Haan, L.A. van Berkel, J.N. Samsom, P.R. Crocker, T. Sparwasser, L. Berod, J.J. Garcia-Vallejo, Y. van Kooyk, and W.W. Unger. 2016. Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells. Proc Natl Acad Sci U S A 113:3329-3334.

Puttur, F., M. Francozo, G. Solmaz, C. Bueno, M. Lindenberg, M. Gohmert, M. Swallow, D. Tufa, R. Jacobs, S. Lienenklaus, A.A. Kuhl, L. Borkner, L. Cicin-Sain, B. Holzmann, H. Wagner, L. Berod, and T. Sparwasser. 2016. Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via TLR9 and MyD88 Signaling. Cell Rep 17:1113-1127.

Raha, S., B. Raud, L. Oberdorfer, C.N. Castro, A. Schreder, J. Freitag, T. Longerich, M. Lochner, T. Sparwasser, L. Berod, C. Koenecke, and I. Prinz. 2016. Disruption of de novo fatty acid synthesis via acetyl-CoA carboxylase 1 inhibition prevents acute graft-versus-host disease. Eur J Immunol 46:2233-2238.

Smith, K.A., K.J. Filbey, L.A. Reynolds, J.P. Hewitson, Y. Harcus, L. Boon, T. Sparwasser, G. Hammerling, and R.M. Maizels. 2016. Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths. Mucosal Immunol 9:428-443.

Win, S.J., A.A. Kuhl, T. Sparwasser, T. Hunig, and T. Kamradt. 2016. In vivo activation of Treg cells with a CD28 superagonist prevents and ameliorates chronic destructive arthritis in mice. Eur J Immunol 46:1193-1202.

Yang, B.H., S. Hagemann, P. Mamareli, U. Lauer, U. Hoffmann, M. Beckstette, L. Fohse, I. Prinz, J. Pezoldt, S. Suerbaum, T. Sparwasser, A. Hamann, S. Floess, J. Huehn, and M. Lochner. 2016. Foxp3(+) T cells expressing RORgammat represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation. Mucosal Immunol 9:444-457.

 

2015

Akeus, P., V. Langenes, J. Kristensen, A. von Mentzer, T. Sparwasser, S. Raghavan, and M. Quiding-Jarbrink. 2015. Treg-cell depletion promotes chemokine production and accumulation of CXCR3(+) conventional T cells in intestinal tumors. Eur J Immunol 45:1654-1666.

Alissafi, T., A. Hatzioannou, M. Ioannou, T. Sparwasser, J.R. Grun, A. Grutzkau, and P. Verginis. 2015. De novo-induced self-antigen-specific Foxp3+ regulatory T cells impair the accumulation of inflammatory dendritic cells in draining lymph nodes. J Immunol 194:5812-5824.

Arnold-Schrauf, C., L. Berod, and T. Sparwasser. 2015. Dendritic cell specific targeting of MyD88 signalling pathways in vivo. Eur J Immunol 45:32-39.

Bolton, H.A., E. Zhu, A.M. Terry, T.V. Guy, W.P. Koh, S.Y. Tan, C.A. Power, P. Bertolino, K. Lahl, T. Sparwasser, E. Shklovskaya, and B. Fazekas de St Groth. 2015. Selective Treg reconstitution during lymphopenia normalizes DC costimulation and prevents graft-versus-host disease. J Clin Invest 125:3627-3641.

Bothur, E., H. Raifer, C. Haftmann, A.B. Stittrich, A. Brustle, D. Brenner, N. Bollig, M. Bieringer, C.H. Kang, K. Reinhard, B. Camara, M. Huber, A. Visekruna, U. Steinhoff, A. Repenning, U.M. Bauer, V. Sexl, A. Radbruch, T. Sparwasser, M.F. Mashreghi, T. Wah Mak, and M. Lohoff. 2015. Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1. Nat Commun 6:8576.

Castro, C.N., J. Freitag, L. Berod, M. Lochner, and T. Sparwasser. 2015. Microbe-associated immunomodulatory metabolites: Influence on T cell fate and function. Mol Immunol 68:575-584.

Dhainaut, M., C. Coquerelle, S. Uzureau, J. Denoeud, V. Acolty, G. Oldenhove, A. Galuppo, T. Sparwasser, K. Thielemans, E. Pays, H. Yagita, J. Borst, and M. Moser. 2015. Thymus-derived regulatory T cells restrain pro-inflammatory Th1 responses by downregulating CD70 on dendritic cells. EMBO J 34:1336-1348.

Khan, A.R., S. Amu, S.P. Saunders, E. Hams, G. Blackshields, M.O. Leonard, C.T. Weaver, T. Sparwasser, O. Sheils, and P.G. Fallon. 2015. Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells. Eur J Immunol 45:1842-1854.

Khan, A.R., E. Hams, A. Floudas, T. Sparwasser, C.T. Weaver, and P.G. Fallon. 2015. PD-L1hi B cells are critical regulators of humoral immunity. Nat Commun 6:5997.

Legoux, F.P., J.B. Lim, A.W. Cauley, S. Dikiy, J. Ertelt, T.J. Mariani, T. Sparwasser, S.S. Way, and J.J. Moon. 2015. CD4+ T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion. Immunity 43:896-908.

Lochner, M., L. Berod, and T. Sparwasser. 2015. Fatty acid metabolism in the regulation of T cell function. Trends Immunol 36:81-91.

Lochner, M., Z. Wang, and T. Sparwasser. 2015. The Special Relationship in the Development and Function of T Helper 17 and Regulatory T Cells. Prog Mol Biol Transl Sci 136:99-129.

Mahapatra, S., M. Albrecht, A.M. Baru, T. Sparwasser, C. Herrick, and A.M. Dittrich. 2015. Superior Suppressive Capacity of Skin Tregs Compared with Lung Tregs in a Model of Epicutaneous Priming. J Invest Dermatol 135:2418-2426.

Molina, M.A., A.M. Diaz, C. Hesse, W. Ginter, M.V. Gentilini, G.G. Nunez, A.M. Canellada, T. Sparwasser, L. Berod, M.S. Castro, and M.A. Manghi. 2015. Immunostimulatory Effects Triggered by Enterococcus faecalis CECT7121 Probiotic Strain Involve Activation of Dendritic Cells and Interferon-Gamma Production. PLoS One 10:e0127262.

Niedzielska, M., F.A. Raffi, J. Tel, S. Muench, K. Jozefowski, N. Alati, K. Lahl, J. Mages, U. Billmeier, M. Schiemann, U.K. Appelt, S. Wirtz, T. Sparwasser, H. Hochrein, C.G. Figdor, S.M. Keyse, and R. Lang. 2015. Selective Expression of the MAPK Phosphatase Dusp9/MKP-4 in Mouse Plasmacytoid Dendritic Cells and Regulation of IFN-beta Production. J Immunol 195:1753-1762.

Schuhmann, M.K., P. Kraft, G. Stoll, K. Lorenz, S.G. Meuth, H. Wiendl, B. Nieswandt, T. Sparwasser, N. Beyersdorf, T. Kerkau, and C. Kleinschnitz. 2015. CD28 superagonist-mediated boost of regulatory T cells increases thrombo-inflammation and ischemic neurodegeneration during the acute phase of experimental stroke. J Cereb Blood Flow Metab 35:6-10.

Tebartz, C., S.A. Horst, T. Sparwasser, J. Huehn, A. Beineke, G. Peters, and E. Medina. 2015. A major role for myeloid-derived suppressor cells and a minor role for regulatory T cells in immunosuppression during Staphylococcus aureus infection. J Immunol 194:1100-1111.

Torow, N., K. Yu, K. Hassani, J. Freitag, O. Schulz, M. Basic, A. Brennecke, T. Sparwasser, N. Wagner, A. Bleich, M. Lochner, S. Weiss, R. Forster, O. Pabst, and M.W. Hornef. 2015. Active suppression of intestinal CD4(+)TCRalphabeta(+) T-lymphocyte maturation during the postnatal period. Nat Commun 6:7725.

Unger, W.W., C.T. Mayer, S. Engels, C. Hesse, M. Perdicchio, F. Puttur, I. Streng-Ouwehand, M. Litjens, H. Kalay, L. Berod, T. Sparwasser, and Y. van Kooyk. 2015. Antigen targeting to dendritic cells combined with transient regulatory T cell inhibition results in long-term tumor regression. Oncoimmunology 4:e970462.

Yang, B.H., S. Floess, S. Hagemann, I.V. Deyneko, L. Groebe, J. Pezoldt, T. Sparwasser, M. Lochner, and J. Huehn. 2015. Development of a unique epigenetic signature during in vivo Th17 differentiation. Nucleic Acids Res 43:1537-1548.

Yodoi, K., T. Yamashita, N. Sasaki, K. Kasahara, T. Emoto, T. Matsumoto, T. Kita, Y. Sasaki, T. Mizoguchi, T. Sparwasser, and K. Hirata. 2015. Foxp3+ regulatory T cells play a protective role in angiotensin II-induced aortic aneurysm formation in mice. Hypertension 65:889-895.

 

2014

Arnold-Schrauf, C., M. Dudek, A. Dielmann, L. Pace, M. Swallow, F. Kruse, A.A. Kuhl, B. Holzmann, L. Berod, and T. Sparwasser. 2014. Dendritic cells coordinate innate immunity via MyD88 signaling to control Listeria monocytogenes infection. Cell Rep 6:698-708.

Berod, L., C. Friedrich, A. Nandan, J. Freitag, S. Hagemann, K. Harmrolfs, A. Sandouk, C. Hesse, C.N. Castro, H. Bahre, S.K. Tschirner, N. Gorinski, M. Gohmert, C.T. Mayer, J. Huehn, E. Ponimaskin, W.R. Abraham, R. Muller, M. Lochner, and T. Sparwasser. 2014. De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat Med 20:1327-1333.

Berod, L., P. Stuve, M. Swallow, C. Arnold-Schrauf, F. Kruse, M.V. Gentilini, J. Freitag, B. Holzmann, and T. Sparwasser. 2014. MyD88 signalling in myeloid cells is sufficient to prevent chronic mycobacterial infection. Eur J Immunol 44:1399-1409.

Berod, L., P. Stuve, F. Varela, J. Behrends, M. Swallow, F. Kruse, F. Krull, P. Ghorbani, C.T. Mayer, C. Holscher, and T. Sparwasser. 2014. Rapid rebound of the Treg compartment in DEREG mice limits the impact of Treg depletion on mycobacterial burden, but prevents autoimmunity. PLoS One 9:e102804.

Blankenhaus, B., M. Reitz, Y. Brenz, M.L. Eschbach, W. Hartmann, I. Haben, T. Sparwasser, J. Huehn, A. Kuhl, T.B. Feyerabend, H.R. Rodewald, and M. Breloer. 2014. Foxp3(+) regulatory T cells delay expulsion of intestinal nematodes by suppression of IL-9-driven mast cell activation in BALB/c but not in C57BL/6 mice. PLoS Pathog 10:e1003913.

Chrobak, P., S. Afkhami, E. Priceputu, J. Poudrier, C. Meunier, Z. Hanna, T. Sparwasser, and P. Jolicoeur. 2014. HIV Nef expression favors the relative preservation of CD4+ T regulatory cells that retain some important suppressive functions. J Immunol 192:1681-1692.

Ehrlich, A., T.M. Castilho, K. Goldsmith-Pestana, W.J. Chae, A.L. Bothwell, T. Sparwasser, and D. McMahon-Pratt. 2014. The immunotherapeutic role of regulatory T cells in Leishmania (Viannia) panamensis infection. J Immunol 193:2961-2970.

Espinoza Mora, M.R., C. Steeg, S. Tartz, V. Heussler, T. Sparwasser, A. Link, B. Fleischer, and T. Jacobs. 2014. Depletion of regulatory T cells augments a vaccine-induced T effector cell response against the liver-stage of malaria but fails to increase memory. PLoS One 9:e104627.

Ganesh, V., A.M. Baru, C. Hesse, C. Friedrich, S. Glage, M. Gohmert, C. Janke, and T. Sparwasser. 2014. Salmonella enterica serovar Typhimurium infection-induced CD11b+ Gr1+ cells ameliorate allergic airway inflammation. Infect Immun 82:1052-1063.

Jost, N.H., S. Abel, M. Hutzler, T. Sparwasser, A. Zimmermann, A. Roers, W. Muller, R. Klopfleisch, H. Hengel, A.M. Westendorf, J. Buer, and W. Hansen. 2014. Regulatory T cells and T-cell-derived IL-10 interfere with effective anti-cytomegalovirus immune response. Immunol Cell Biol 92:860-871.

Lindenberg, M., G. Solmaz, F. Puttur, and T. Sparwasser. 2014. Mouse cytomegalovirus infection overrules T regulatory cell suppression on natural killer cells. Virol J 11:145.

Mayer, C.T., P. Ghorbani, A.A. Kuhl, P. Stuve, M. Hegemann, L. Berod, M.E. Gershwin, and T. Sparwasser. 2014. Few Foxp3(+) regulatory T cells are sufficient to protect adult mice from lethal autoimmunity. Eur J Immunol 44:2990-3002.

Mayer, C.T., P. Ghorbani, A. Nandan, M. Dudek, C. Arnold-Schrauf, C. Hesse, L. Berod, P. Stuve, F. Puttur, M. Merad, and T. Sparwasser. 2014. Selective and efficient generation of functional Batf3-dependent CD103+ dendritic cells from mouse bone marrow. Blood 124:3081-3091.

Mayer, C.T., K. Lahl, P. Milanez-Almeida, D. Watts, U. Dittmer, N. Fyhrquist, J. Huehn, M. Kopf, K. Kretschmer, B. Rouse, and T. Sparwasser. 2014. Advantages of Foxp3(+) regulatory T cell depletion using DEREG mice. Immun Inflamm Dis 2:162-165.

Mayer, C.T., and T. Sparwasser. 2014. Assessing the suppressive activity of Foxp3(+) regulatory T cells. Methods Mol Biol 1193:85-96.

Mayer, C.T., L. Tian, C. Hesse, A.A. Kuhl, M. Swallow, F. Kruse, M. Thiele, M.E. Gershwin, A. Liston, and T. Sparwasser. 2014. Anti-CD4 treatment inhibits autoimmunity in scurfy mice through the attenuation of co-stimulatory signals. J Autoimmun 50:23-32.

Meyer zu Horste, G., S. Cordes, A.K. Mausberg, A.L. Zozulya, C. Wessig, T. Sparwasser, C. Mathys, H. Wiendl, H.P. Hartung, and B.C. Kieseier. 2014. FoxP3+ regulatory T cells determine disease severity in rodent models of inflammatory neuropathies. PLoS One 9:e108756.

Niedzielska, M., B. Bodendorfer, S. Munch, A. Eichner, M. Derigs, O. da Costa, A. Schweizer, F. Neff, L. Nitschke, T. Sparwasser, S.M. Keyse, and R. Lang. 2014. Gene trap mice reveal an essential function of dual specificity phosphatase Dusp16/MKP-7 in perinatal survival and regulation of Toll-like receptor (TLR)-induced cytokine production. J Biol Chem 289:2112-2126.

Pastille, E., K. Bardini, D. Fleissner, A. Adamczyk, A. Frede, M. Wadwa, D. von Smolinski, S. Kasper, T. Sparwasser, A.D. Gruber, M. Schuler, S. Sakaguchi, A. Roers, W. Muller, W. Hansen, J. Buer, and A.M. Westendorf. 2014. Transient ablation of regulatory T cells improves antitumor immunity in colitis-associated colon cancer. Cancer Res 74:4258-4269.

Petzold, C., N. Steinbronn, M. Gereke, R.H. Strasser, T. Sparwasser, D. Bruder, R. Geffers, S. Schallenberg, and K. Kretschmer. 2014. Fluorochrome-based definition of naturally occurring Foxp3(+) regulatory T cells of intra- and extrathymic origin. Eur J Immunol 44:3632-3645.

Schulze, B., D. Piehler, M. Eschke, H. von Buttlar, G. Kohler, T. Sparwasser, and G. Alber. 2014. CD4(+) FoxP3(+) regulatory T cells suppress fatal T helper 2 cell immunity during pulmonary fungal infection. Eur J Immunol 44:3596-3604.

Villalta, S.A., W. Rosenthal, L. Martinez, A. Kaur, T. Sparwasser, J.G. Tidball, M. Margeta, M.J. Spencer, and J.A. Bluestone. 2014. Regulatory T cells suppress muscle inflammation and injury in muscular dystrophy. Sci Transl Med 6:258ra142.

Wang, Y., T. Sparwasser, R. Figlin, and H.L. Kim. 2014. Foxp3+ T cells inhibit antitumor immune memory modulated by mTOR inhibition. Cancer Res 74:2217-2228.

Wang, Z., C. Friedrich, S.C. Hagemann, W.H. Korte, N. Goharani, S. Cording, G. Eberl, T. Sparwasser*, and M. Lochner*. 2014. Regulatory T cells promote a protective Th17-associated immune response to intestinal bacterial infection with C. rodentium. Mucosal Immunol 7:1290-1301. *equally contributed

 

2013

Akhmetzyanova, I., G. Zelinskyy, S. Schimmer, S. Brandau, P. Altenhoff, T. Sparwasser, and U. Dittmer. 2013. Tumor-specific CD4+ T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells. Cancer Immunol Immunother 62:257-271.

Chai, Q., L. Onder, E. Scandella, C. Gil-Cruz, C. Perez-Shibayama, J. Cupovic, R. Danuser, T. Sparwasser, S.A. Luther, V. Thiel, T. Rulicke, J.V. Stein, T. Hehlgans, and B. Ludewig. 2013. Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity. Immunity 38:1013-1024.

Fernandez, M.A., U. Yu, G. Zhang, R. White, T. Sparwasser, S.I. Alexander, and C.A. Jones. 2013. Treg depletion attenuates the severity of skin disease from ganglionic spread after HSV-2 flank infection. Virology 447:9-20.

Hesse, C., W. Ginter, T. Forg, C.T. Mayer, A.M. Baru, C. Arnold-Schrauf, W.W. Unger, H. Kalay, Y. van Kooyk, L. Berod, and T. Sparwasser. 2013. In vivo targeting of human DC-SIGN drastically enhances CD8(+) T-cell-mediated protective immunity. Eur J Immunol 43:2543-2553.

Hu, M., C. Wang, G.Y. Zhang, M. Saito, Y.M. Wang, M.A. Fernandez, Y. Wang, H. Wu, W.J. Hawthorne, C. Jones, P.J. O'Connell, T. Sparwasser, G.A. Bishop, A.F. Sharland, and S.I. Alexander. 2013. Infiltrating Foxp3(+) regulatory T cells from spontaneously tolerant kidney allografts demonstrate donor-specific tolerance. Am J Transplant 13:2819-2830.

Kanjarawi, R., M. Dy, E. Bardel, T. Sparwasser, B. Dubois, S. Mecheri, and D. Kaiserlian. 2013. Regulatory CD4+Foxp3+ T cells control the severity of anaphylaxis. PLoS One 8:e69183.

Kleinschnitz, C., P. Kraft, A. Dreykluft, I. Hagedorn, K. Gobel, M.K. Schuhmann, F. Langhauser, X. Helluy, T. Schwarz, S. Bittner, C.T. Mayer, M. Brede, C. Varallyay, M. Pham, M. Bendszus, P. Jakob, T. Magnus, S.G. Meuth, Y. Iwakura, A. Zernecke, T. Sparwasser, B. Nieswandt, G. Stoll, and H. Wiendl. 2013. Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. Blood 121:679-691.

Klingenberg, R., N. Gerdes, R.M. Badeau, A. Gistera, D. Strodthoff, D.F. Ketelhuth, A.M. Lundberg, M. Rudling, S.K. Nilsson, G. Olivecrona, S. Zoller, C. Lohmann, T.F. Luscher, M. Jauhiainen, T. Sparwasser, and G.K. Hansson. 2013. Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis. J Clin Invest 123:1323-1334.

Kuhlhorn, F., M. Rath, K. Schmoeckel, K. Cziupka, H.H. Nguyen, P. Hildebrandt, T. Hunig, T. Sparwasser, J. Huehn, C. Potschke, and B.M. Broker. 2013. Foxp3+ regulatory T cells are required for recovery from severe sepsis. PLoS One 8:e65109.

Layland, L.E., K. Straubinger, M. Ritter, E. Loffredo-Verde, H. Garn, T. Sparwasser, and C. Prazeres da Costa. 2013. Schistosoma mansoni-mediated suppression of allergic airway inflammation requires patency and Foxp3+ Treg cells. PLoS Negl Trop Dis 7:e2379.

Martin, B., C. Auffray, A. Delpoux, A. Pommier, A. Durand, C. Charvet, P. Yakonowsky, H. de Boysson, N. Bonilla, A. Audemard, T. Sparwasser, B.L. Salomon, B. Malissen, and B. Lucas. 2013. Highly self-reactive naive CD4 T cells are prone to differentiate into regulatory T cells. Nat Commun 4:2209.

Mayer, C.T., J. Huntenburg, A. Nandan, E. Schmitt, N. Czeloth, and T. Sparwasser. 2013. CD4 blockade directly inhibits mouse and human CD4(+) T cell functions independent of Foxp3(+) Tregs. J Autoimmun 47:73-82.

Pasquet, L., J.Y. Douet, T. Sparwasser, P. Romagnoli, and J.P. van Meerwijk. 2013. Long-term prevention of chronic allograft rejection by regulatory T-cell immunotherapy involves host Foxp3-expressing T cells. Blood 121:4303-4310.

Petzold, C., J. Riewaldt, D. Watts, T. Sparwasser, S. Schallenberg, and K. Kretschmer. 2013. Foxp3(+) regulatory T cells in mouse models of type 1 diabetes. J Diabetes Res 2013:940710.

Puttur, F., C. Arnold-Schrauf, K. Lahl, G. Solmaz, M. Lindenberg, C.T. Mayer, M. Gohmert, M. Swallow, C. van Helt, H. Schmitt, L. Nitschke, B.N. Lambrecht, R. Lang, M. Messerle, and T. Sparwasser. 2013. Absence of Siglec-H in MCMV infection elevates interferon alpha production but does not enhance viral clearance. PLoS Pathog 9:e1003648.

Rosalia, R.A., I. Stepanek, V. Pollakova, J. Simova, J. Bieblova, M. Indrova, S. Moravcova, H. Pribylova, H.J. Bontkes, J. Bubenik, T. Sparwasser, and M. Reinis. 2013. Administration of anti-CD25 mAb leads to impaired alpha-galactosylceramide-mediated induction of IFN-gamma production in a murine model. Immunobiology 218:851-859.

Schmitz, I., C. Schneider, A. Frohlich, H. Frebel, D. Christ, W.J. Leonard, T. Sparwasser, A. Oxenius, S. Freigang, and M. Kopf. 2013. IL-21 restricts virus-driven Treg cell expansion in chronic LCMV infection. PLoS Pathog 9:e1003362.

Worthington, J.J., J.E. Klementowicz, S. Rahman, B.I. Czajkowska, C. Smedley, H. Waldmann, T. Sparwasser, R.K. Grencis, and M.A. Travis. 2013. Loss of the TGFbeta-activating integrin alphavbeta8 on dendritic cells protects mice from chronic intestinal parasitic infection via control of type 2 immunity. PLoS Pathog 9:e1003675.

 

2012

Abel, S., N. Luckheide, A.M. Westendorf, R. Geffers, A. Roers, W. Muller, T. Sparwasser, K. Matuschewski, J. Buer, and W. Hansen. 2012. Strong impact of CD4+ Foxp3+ regulatory T cells and limited effect of T cell-derived IL-10 on pathogen clearance during Plasmodium yoelii infection. J Immunol 188:5467-5477.

Auriemma, M., T. Brzoska, L. Klenner, V. Kupas, T. Goerge, M. Voskort, Z. Zhao, T. Sparwasser, T.A. Luger, and K. Loser. 2012. alpha-MSH-stimulated tolerogenic dendritic cells induce functional regulatory T cells and ameliorate ongoing skin inflammation. J Invest Dermatol 132:1814-1824.

Baru, A.M., V. Ganesh, J.K. Krishnaswamy, C. Hesse, C. Untucht, S. Glage, G. Behrens, C.T. Mayer, F. Puttur, and T. Sparwasser. 2012. Absence of Foxp3+ regulatory T cells during allergen provocation does not exacerbate murine allergic airway inflammation. PLoS One 7:e47102.

Baru, A.M., C. Untucht, V. Ganesh, C. Hesse, C.T. Mayer, and T. Sparwasser. 2012. Optimal isolation of functional Foxp3+ induced regulatory T cells using DEREG mice. PLoS One 7:e44760.

Berod, L., F. Puttur, J. Huehn, and T. Sparwasser. 2012. Tregs in infection and vaccinology: heroes or traitors? Microb Biotechnol 5:260-269.

Cervantes-Barragan, L., S. Firner, I. Bechmann, A. Waisman, K. Lahl, T. Sparwasser, V. Thiel, and B. Ludewig. 2012. Regulatory T cells selectively preserve immune privilege of self-antigens during viral central nervous system infection. J Immunol 188:3678-3685.

Eberlein, J., B. Davenport, T.T. Nguyen, F. Victorino, T. Sparwasser, and D. Homann. 2012. Multiple layers of CD80/86-dependent costimulatory activity regulate primary, memory, and secondary lymphocytic choriomeningitis virus-specific T cell immunity. J Virol 86:1955-1970.

Fyhrquist, N., S. Lehtimaki, K. Lahl, T. Savinko, A.M. Lappetelainen, T. Sparwasser, H. Wolff, A. Lauerma, and H. Alenius. 2012. Foxp3+ cells control Th2 responses in a murine model of atopic dermatitis. J Invest Dermatol 132:1672-1680.

Gomez de Aguero, M., M. Vocanson, F. Hacini-Rachinel, M. Taillardet, T. Sparwasser, A. Kissenpfennig, B. Malissen, D. Kaiserlian, and B. Dubois. 2012. Langerhans cells protect from allergic contact dermatitis in mice by tolerizing CD8(+) T cells and activating Foxp3(+) regulatory T cells. J Clin Invest 122:1700-1711.

Hansen, W., M. Hutzler, S. Abel, C. Alter, C. Stockmann, S. Kliche, J. Albert, T. Sparwasser, S. Sakaguchi, A.M. Westendorf, D. Schadendorf, J. Buer, and I. Helfrich. 2012. Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth. J Exp Med 209:2001-2016.

Hellingman, A.A., L.E. van der Vlugt, M.A. Lijkwan, A.J. Bastiaansen, T. Sparwasser, H.H. Smits, J.F. Hamming, and P.H. Quax. 2012. A limited role for regulatory T cells in post-ischemic neovascularization. J Cell Mol Med 16:328-336.

Krishnaswamy, J.K., A.C. Jirmo, A.M. Baru, T. Ebensen, C.A. Guzman, T. Sparwasser, and G.M. Behrens. 2012. Toll-like receptor-2 agonist-allergen coupling efficiently redirects Th2 cell responses and inhibits allergic airway eosinophilia. Am J Respir Cell Mol Biol 47:852-863.

Lehtimaki, S., T. Savinko, K. Lahl, T. Sparwasser, H. Wolff, A. Lauerma, H. Alenius, and N. Fyhrquist. 2012. The temporal and spatial dynamics of Foxp3+ Treg cell-mediated suppression during contact hypersensitivity responses in a murine model. J Invest Dermatol 132:2744-2751.

Loebbermann, J., H. Thornton, L. Durant, T. Sparwasser, K.E. Webster, J. Sprent, F.J. Culley, C. Johansson, and P.J. Openshaw. 2012. Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection. Mucosal Immunol 5:161-172.

Maazi, H., S. Shirinbak, M. Willart, H.M. Hammad, M. Cabanski, L. Boon, V. Ganesh, A.M. Baru, G. Hansen, B.N. Lambrecht, T. Sparwasser, M.C. Nawijn, and A.J. van Oosterhout. 2012. Contribution of regulatory T cells to alleviation of experimental allergic asthma after specific immunotherapy. Clin Exp Allergy 42:1519-1528.

Mayer, C.T., L. Berod, and T. Sparwasser. 2012. Layers of dendritic cell-mediated T cell tolerance, their regulation and the prevention of autoimmunity. Front Immunol 3:183.

Mayer, C.T., A.A. Kuhl, C. Loddenkemper, and T. Sparwasser. 2012. Lack of Foxp3+ macrophages in both untreated and B16 melanoma-bearing mice. Blood 119:1314-1315.

Navid, F., M. Boniotto, C. Walker, K. Ahrens, E. Proksch, T. Sparwasser, W. Muller, T. Schwarz, and A. Schwarz. 2012. Induction of regulatory T cells by a murine beta-defensin. J Immunol 188:735-743.

Ohkura, N., M. Hamaguchi, H. Morikawa, K. Sugimura, A. Tanaka, Y. Ito, M. Osaki, Y. Tanaka, R. Yamashita, N. Nakano, J. Huehn, H.J. Fehling, T. Sparwasser, K. Nakai, and S. Sakaguchi. 2012. T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. Immunity 37:785-799.

Pace, L., A. Tempez, C. Arnold-Schrauf, F. Lemaitre, P. Bousso, L. Fetler, T. Sparwasser, and S. Amigorena. 2012. Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory. Science 338:532-536.

Panzer, M., S. Sitte, S. Wirth, I. Drexler, T. Sparwasser, and D. Voehringer. 2012. Rapid in vivo conversion of effector T cells into Th2 cells during helminth infection. J Immunol 188:615-623.

Reuter, D., T. Sparwasser, T. Hunig, and J. Schneider-Schaulies. 2012. Foxp3+ regulatory T cells control persistence of viral CNS infection. PLoS One 7:e33989.

Robb, R.J., K.E. Lineburg, R.D. Kuns, Y.A. Wilson, N.C. Raffelt, S.D. Olver, A. Varelias, K.A. Alexander, B.E. Teal, T. Sparwasser, G.J. Hammerling, K.A. Markey, M. Koyama, A.D. Clouston, C.R. Engwerda, G.R. Hill, and K.P. MacDonald. 2012. Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation. Blood 119:5898-5908.

Schallenberg, S., C. Petzold, P.Y. Tsai, T. Sparwasser, and K. Kretschmer. 2012. Vagaries of fluorochrome reporter gene expression in Foxp3+ regulatory T cells. PLoS One 7:e41971.

Schuster, M., R. Glauben, C. Plaza-Sirvent, L. Schreiber, M. Annemann, S. Floess, A.A. Kuhl, L.K. Clayton, T. Sparwasser, K. Schulze-Osthoff, K. Pfeffer, J. Huehn, B. Siegmund, and I. Schmitz. 2012. IkappaB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor. Immunity 37:998-1008.

Schwarz, A., F. Navid, T. Sparwasser, B.E. Clausen, and T. Schwarz. 2012. 1,25-dihydroxyvitamin D exerts similar immunosuppressive effects as UVR but is dispensable for local UVR-induced immunosuppression. J Invest Dermatol 132:2762-2769.

Stross, L., J. Gunther, G. Gasteiger, T. Asen, S. Graf, M. Aichler, I. Esposito, D.H. Busch, P. Knolle, T. Sparwasser, and U. Protzer. 2012. Foxp3+ regulatory T cells protect the liver from immune damage and compromise virus control during acute experimental hepatitis B virus infection in mice. Hepatology 56:873-883.

van der Vlugt, L.E., L.A. Labuda, A. Ozir-Fazalalikhan, E. Lievers, A.K. Gloudemans, K.Y. Liu, T.A. Barr, T. Sparwasser, L. Boon, U.A. Ngoa, E.N. Feugap, A.A. Adegnika, P.G. Kremsner, D. Gray, M. Yazdanbakhsh, and H.H. Smits. 2012. Schistosomes induce regulatory features in human and mouse CD1d(hi) B cells: inhibition of allergic inflammation by IL-10 and regulatory T cells. PLoS One 7:e30883.

Veiga-Parga, T., A. Suryawanshi, S. Mulik, F. Gimenez, S. Sharma, T. Sparwasser, and B.T. Rouse. 2012. On the role of regulatory T cells during viral-induced inflammatory lesions. J Immunol 189:5924-5933.

Zhao, E., L. Wang, J. Dai, I. Kryczek, S. Wei, L. Vatan, S. Altuwaijri, T. Sparwasser, G. Wang, E.T. Keller, and W. Zou. 2012. Regulatory T cells in the bone marrow microenvironment in patients with prostate cancer. Oncoimmunology 1:152-161.

 

2011

Arnold, I.C., J.Y. Lee, M.R. Amieva, A. Roers, R.A. Flavell, T. Sparwasser, and A. Muller. 2011. Tolerance rather than immunity protects from Helicobacter pylori-induced gastric preneoplasia. Gastroenterology 140:199-209.

Beyer, M., Y. Thabet, R.U. Muller, T. Sadlon, S. Classen, K. Lahl, S. Basu, X. Zhou, S.L. Bailey-Bucktrout, W. Krebs, E.A. Schonfeld, J. Bottcher, T. Golovina, C.T. Mayer, A. Hofmann, D. Sommer, S. Debey-Pascher, E. Endl, A. Limmer, K.L. Hippen, B.R. Blazar, R. Balderas, T. Quast, A. Waha, G. Mayer, M. Famulok, P.A. Knolle, C. Wickenhauser, W. Kolanus, B. Schermer, J.A. Bluestone, S.C. Barry, T. Sparwasser, J.L. Riley, and J.L. Schultze. 2011. Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nat Immunol 12:898-907.

Blankenhaus, B., U. Klemm, M.L. Eschbach, T. Sparwasser, J. Huehn, A.A. Kuhl, C. Loddenkemper, T. Jacobs, and M. Breloer. 2011. Strongyloides ratti infection induces expansion of Foxp3+ regulatory T cells that interfere with immune response and parasite clearance in BALB/c mice. J Immunol 186:4295-4305.

Cassani, B., E.J. Villablanca, F.J. Quintana, P.E. Love, A. Lacy-Hulbert, W.S. Blaner, T. Sparwasser, S.B. Snapper, H.L. Weiner, and J.R. Mora. 2011. Gut-tropic T cells that express integrin alpha4beta7 and CCR9 are required for induction of oral immune tolerance in mice. Gastroenterology 141:2109-2118.

Dietze, K.K., G. Zelinskyy, K. Gibbert, S. Schimmer, S. Francois, L. Myers, T. Sparwasser, K.J. Hasenkrug, and U. Dittmer. 2011. Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8+ T cells and reduces chronic retroviral set points. Proc Natl Acad Sci U S A 108:2420-2425.

Hackl, D., J. Loschko, T. Sparwasser, W. Reindl, and A.B. Krug. 2011. Activation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced Tregs. Eur J Immunol 41:1334-1343.

Hadis, U., B. Wahl, O. Schulz, M. Hardtke-Wolenski, A. Schippers, N. Wagner, W. Muller, T. Sparwasser, R. Forster, and O. Pabst. 2011. Intestinal tolerance requires gut homing and expansion of FoxP3+ regulatory T cells in the lamina propria. Immunity 34:237-246.

Kastenmuller, W., G. Gasteiger, N. Subramanian, T. Sparwasser, D.H. Busch, Y. Belkaid, I. Drexler, and R.N. Germain. 2011. Regulatory T cells selectively control CD8+ T cell effector pool size via IL-2 restriction. J Immunol 187:3186-3197.

Lahl, K., and T. Sparwasser. 2011. In vivo depletion of FoxP3+ Tregs using the DEREG mouse model. Methods Mol Biol 707:157-172.

Lo Re, S., M. Lecocq, F. Uwambayinema, Y. Yakoub, M. Delos, J.B. Demoulin, S. Lucas, T. Sparwasser, J.C. Renauld, D. Lison, and F. Huaux. 2011. Platelet-derived growth factor-producing CD4+ Foxp3+ regulatory T lymphocytes promote lung fibrosis. Am J Respir Crit Care Med 184:1270-1281.

Mayer, C.T., S. Floess, A.M. Baru, K. Lahl, J. Huehn, and T. Sparwasser. 2011. CD8+ Foxp3+ T cells share developmental and phenotypic features with classical CD4+ Foxp3+ regulatory T cells but lack potent suppressive activity. Eur J Immunol 41:716-725.

McNally, A., G.R. Hill, T. Sparwasser, R. Thomas, and R.J. Steptoe. 2011. CD4+CD25+ regulatory T cells control CD8+ T-cell effector differentiation by modulating IL-2 homeostasis. Proc Natl Acad Sci U S A 108:7529-7534.

Navarro, S., G. Cossalter, C. Chiavaroli, A. Kanda, S. Fleury, A. Lazzari, J. Cazareth, T. Sparwasser, D. Dombrowicz, N. Glaichenhaus, and V. Julia. 2011. The oral administration of bacterial extracts prevents asthma via the recruitment of regulatory T cells to the airways. Mucosal Immunol 4:53-65.

Olivier, A., A. Sainz-Perez, H. Dong, T. Sparwasser, L. Majlessi, and C. Leclerc. 2011. The adjuvant effect of TLR agonists on CD4(+) effector T cells is under the indirect control of regulatory T cells. Eur J Immunol 41:2303-2313.

Onder, L., E. Scandella, Q. Chai, S. Firner, C.T. Mayer, T. Sparwasser, V. Thiel, T. Rulicke, and B. Ludewig. 2011. A novel bacterial artificial chromosome-transgenic podoplanin-cre mouse targets lymphoid organ stromal cells in vivo. Front Immunol 2:50.

Paust, H.J., A. Ostmann, A. Erhardt, J.E. Turner, J. Velden, H.W. Mittrucker, T. Sparwasser, U. Panzer, and G. Tiegs. 2011. Regulatory T cells control the Th1 immune response in murine crescentic glomerulonephritis. Kidney Int 80:154-164.

Pellegrini, M., T. Calzascia, J.G. Toe, S.P. Preston, A.E. Lin, A.R. Elford, A. Shahinian, P.A. Lang, K.S. Lang, M. Morre, B. Assouline, K. Lahl, T. Sparwasser, T.F. Tedder, J.H. Paik, R.A. DePinho, S. Basta, P.S. Ohashi, and T.W. Mak. 2011. IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell 144:601-613.

Schwarz, A., F. Navid, T. Sparwasser, B.E. Clausen, and T. Schwarz. 2011. In vivo reprogramming of UV radiation-induced regulatory T-cell migration to inhibit the elicitation of contact hypersensitivity. J Allergy Clin Immunol 128:826-833.

Seung, E., J.L. Cho, T. Sparwasser, B.D. Medoff, and A.D. Luster. 2011. Inhibiting CXCR3-dependent CD8+ T cell trafficking enhances tolerance induction in a mouse model of lung rejection. J Immunol 186:6830-6838.

Stagg, J., U. Divisekera, H. Duret, T. Sparwasser, M.W. Teng, P.K. Darcy, and M.J. Smyth. 2011. CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis. Cancer Res 71:2892-2900.

Tacken, P.J., W. Ginter, L. Berod, L.J. Cruz, B. Joosten, T. Sparwasser, C.G. Figdor, and A. Cambi. 2011. Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation. Blood 118:4111-4119.

Vaeth, M., T. Gogishvili, T. Bopp, M. Klein, F. Berberich-Siebelt, S. Gattenloehner, A. Avots, T. Sparwasser, N. Grebe, E. Schmitt, T. Hunig, E. Serfling, and J. Bodor. 2011. Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1). Proc Natl Acad Sci U S A 108:2480-2485.

Weiss, E.M., A. Schmidt, D. Vobis, N. Garbi, K. Lahl, C.T. Mayer, T. Sparwasser, A. Ludwig, E. Suri-Payer, N. Oberle, and P.H. Krammer. 2011. Foxp3-mediated suppression of CD95L expression confers resistance to activation-induced cell death in regulatory T cells. J Immunol 187:1684-1691.

Wheeler, K., S. Tardif, C. Rival, B. Luu, E. Bui, R. Del Rio, C. Teuscher, T. Sparwasser, D. Hardy, and K.S. Tung. 2011. Regulatory T cells control tolerogenic versus autoimmune response to sperm in vasectomy. Proc Natl Acad Sci U S A 108:7511-7516.

Wilhelm, C., K. Hirota, B. Stieglitz, J. Van Snick, M. Tolaini, K. Lahl, T. Sparwasser, H. Helmby, and B. Stockinger. 2011. An IL-9 fate reporter demonstrates the induction of an innate IL-9 response in lung inflammation. Nat Immunol 12:1071-1077.

Woller, N., S. Knocke, B. Mundt, E. Gurlevik, N. Struver, A. Kloos, B. Boozari, P. Schache, M.P. Manns, N.P. Malek, T. Sparwasser, L. Zender, T.C. Wirth, S. Kubicka, and F. Kuhnel. 2011. Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice. J Clin Invest 121:2570-2582.

 

2010

Anz, D., V.H. Koelzer, S. Moder, R. Thaler, T. Schwerd, K. Lahl, T. Sparwasser, R. Besch, H. Poeck, V. Hornung, G. Hartmann, S. Rothenfusser, C. Bourquin, and S. Endres. 2010. Immunostimulatory RNA blocks suppression by regulatory T cells. J Immunol 184:939-946.

Baru, A.M., A. Hartl, K. Lahl, J.K. Krishnaswamy, H. Fehrenbach, A.O. Yildirim, H. Garn, H. Renz, G.M. Behrens, and T. Sparwasser. 2010. Selective depletion of Foxp3+ Treg during sensitization phase aggravates experimental allergic airway inflammation. Eur J Immunol 40:2259-2266.

Boissonnas, A., A. Scholer-Dahirel, V. Simon-Blancal, L. Pace, F. Valet, A. Kissenpfennig, T. Sparwasser, B. Malissen, L. Fetler, and S. Amigorena. 2010. Foxp3+ T cells induce perforin-dependent dendritic cell death in tumor-draining lymph nodes. Immunity 32:266-278.

Engel, D.R., A. Koscielny, S. Wehner, J. Maurer, M. Schiwon, L. Franken, B. Schumak, A. Limmer, T. Sparwasser, A. Hirner, P.A. Knolle, J.C. Kalff, and C. Kurts. 2010. T helper type 1 memory cells disseminate postoperative ileus over the entire intestinal tract. Nat Med 16:1407-1413.

Hamm, S., E. Latz, D. Hangel, T. Muller, P. Yu, D. Golenbock, T. Sparwasser, H. Wagner, and S. Bauer. 2010. Alternating 2'-O-ribose methylation is a universal approach for generating non-stimulatory siRNA by acting as TLR7 antagonist. Immunobiology 215:559-569.

Haque, A., S.E. Best, F.H. Amante, S. Mustafah, L. Desbarrieres, F. de Labastida, T. Sparwasser, G.R. Hill, and C.R. Engwerda. 2010. CD4+ natural regulatory T cells prevent experimental cerebral malaria via CTLA-4 when expanded in vivo. PLoS Pathog 6:e1001221.

Hubert, S., B. Rissiek, K. Klages, J. Huehn, T. Sparwasser, F. Haag, F. Koch-Nolte, O. Boyer, M. Seman, and S. Adriouch. 2010. Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway. J Exp Med 207:2561-2568.

Klages, K., C.T. Mayer, K. Lahl, C. Loddenkemper, M.W. Teng, S.F. Ngiow, M.J. Smyth, A. Hamann, J. Huehn, and T. Sparwasser. 2010. Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma. Cancer Res 70:7788-7799.

Pechloff, K., J. Holch, U. Ferch, M. Schweneker, K. Brunner, M. Kremer, T. Sparwasser, L. Quintanilla-Martinez, U. Zimber-Strobl, B. Streubel, A. Gewies, C. Peschel, and J. Ruland. 2010. The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma. J Exp Med 207:1031-1044.

Schildknecht, A., S. Brauer, C. Brenner, K. Lahl, H. Schild, T. Sparwasser*, H.C. Probst*, and M. van den Broek*. 2010. FoxP3+ regulatory T cells essentially contribute to peripheral CD8+ T-cell tolerance induced by steady-state dendritic cells. Proc Natl Acad Sci U S A 107:199-203. *equally contributed

Suttner, K., M. Depner, M. Wetzke, N. Klopp, E. von Mutius, T. Illig, T. Sparwasser, and M. Kabesch. 2010. Genetic variants harbored in the forkhead box protein 3 locus increase hay fever risk. J Allergy Clin Immunol 125:1395-1399.

Teng, M.W., S.F. Ngiow, B. von Scheidt, N. McLaughlin, T. Sparwasser, and M.J. Smyth. 2010. Conditional regulatory T-cell depletion releases adaptive immunity preventing carcinogenesis and suppressing established tumor growth. Cancer Res 70:7800-7809.

 

2009

Kim, J., K. Lahl, S. Hori, C. Loddenkemper, A. Chaudhry, P. deRoos, A. Rudensky, and T. Sparwasser. 2009. Cutting edge: depletion of Foxp3+ cells leads to induction of autoimmunity by specific ablation of regulatory T cells in genetically targeted mice. J Immunol 183:7631-7634.

Lahl, K., C.T. Mayer, T. Bopp, J. Huehn, C. Loddenkemper, G. Eberl, G. Wirnsberger, K. Dornmair, R. Geffers, E. Schmitt, J. Buer, and T. Sparwasser. 2009. Nonfunctional regulatory T cells and defective control of Th2 cytokine production in natural scurfy mutant mice. J Immunol 183:5662-5672.

Pellegrini, M., T. Calzascia, A.R. Elford, A. Shahinian, A.E. Lin, D. Dissanayake, S. Dhanji, L.T. Nguyen, M.A. Gronski, M. Morre, B. Assouline, K. Lahl, T. Sparwasser, P.S. Ohashi, and T.W. Mak. 2009. Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies. Nat Med 15:528-536.

Rausch, S., J. Huehn, C. Loddenkemper, M.R. Hepworth, C. Klotz, T. Sparwasser, A. Hamann, R. Lucius, and S. Hartmann. 2009. Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3+ cells. Eur J Immunol 39:3066-3077.

Siegemund, S., A. Hartl, H. von Buttlar, F. Dautel, R. Raue, M.A. Freudenberg, G. Fejer, M. Buttner, G. Kohler, C.J. Kirschning, T. Sparwasser, and G. Alber. 2009. Conventional bone marrow-derived dendritic cells contribute to toll-like receptor-independent production of alpha/beta interferon in response to inactivated parapoxvirus ovis. J Virol 83:9411-9422.

Singh, S.K., J. Stephani, M. Schaefer, H. Kalay, J.J. Garcia-Vallejo, J. den Haan, E. Saeland, T. Sparwasser, and Y. van Kooyk. 2009. Targeting glycan modified OVA to murine DC-SIGN transgenic dendritic cells enhances MHC class I and II presentation. Mol Immunol 47:164-174.

Steeg, C., G. Adler, T. Sparwasser, B. Fleischer, and T. Jacobs. 2009. Limited role of CD4+Foxp3+ regulatory T cells in the control of experimental cerebral malaria. J Immunol 183:7014-7022.

von Allmen, C.E., N. Schmitz, M. Bauer, H.J. Hinton, M.O. Kurrer, R.B. Buser, M. Gwerder, S. Muntwiler, T. Sparwasser, R.R. Beerli, and M.F. Bachmann. 2009. Secretory phospholipase A2-IID is an effector molecule of CD4+CD25+ regulatory T cells. Proc Natl Acad Sci U S A 106:11673-11678.

Zelinskyy, G., K. Dietze, T. Sparwasser, and U. Dittmer. 2009. Regulatory T cells suppress antiviral immune responses and increase viral loads during acute infection with a lymphotropic retrovirus. PLoS Pathog 5:e1000406.

Zelinskyy, G., K.K. Dietze, Y.P. Husecken, S. Schimmer, S. Nair, T. Werner, K. Gibbert, O. Kershaw, A.D. Gruber, T. Sparwasser, and U. Dittmer. 2009. The regulatory T-cell response during acute retroviral infection is locally defined and controls the magnitude and duration of the virus-specific cytotoxic T-cell response. Blood 114:3199-3207.

 

2008

Heit, A., F. Gebhardt, K. Lahl, M. Neuenhahn, F. Schmitz, F. Anderl, H. Wagner, T. Sparwasser*, D.H. Busch*, and K. Kastenmuller*. 2008. Circumvention of regulatory CD4(+) T cell activity during cross-priming strongly enhances T cell-mediated immunity. Eur J Immunol 38:1585-1597. *equally contributed

Osorio, F., S. LeibundGut-Landmann, M. Lochner, K. Lahl, T. Sparwasser, G. Eberl, and C. Reis e Sousa. 2008. DC activated via dectin-1 convert Treg into IL-17 producers. Eur J Immunol 38:3274-3281.

Schaefer, M., N. Reiling, C. Fessler, J. Stephani, I. Taniuchi, F. Hatam, A.O. Yildirim, H. Fehrenbach, K. Walter, J. Ruland, H. Wagner, S. Ehlers, and T. Sparwasser. 2008. Decreased pathology and prolonged survival of human DC-SIGN transgenic mice during mycobacterial infection. J Immunol 180:6836-6845.

 

2007

Lahl, K., C. Loddenkemper, C. Drouin, J. Freyer, J. Arnason, G. Eberl, A. Hamann, H. Wagner, J. Huehn, and T. Sparwasser. 2007. Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med 204:57-63.

Sparwasser, T., and G. Eberl. 2007. BAC to immunology--bacterial artificial chromosome-mediated transgenesis for targeting of immune cells. Immunology 121:308-313.

 

2006

Gross, O., A. Gewies, K. Finger, M. Schafer, T. Sparwasser, C. Peschel, I. Forster, and J. Ruland. 2006. Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity. Nature 442:651-656.

Klemm, S., J. Gutermuth, L. Hultner, T. Sparwasser, H. Behrendt, C. Peschel, T.W. Mak, T. Jakob, and J. Ruland. 2006. The Bcl10-Malt1 complex segregates Fc epsilon RI-mediated nuclear factor kappa B activation and cytokine production from mast cell degranulation. J Exp Med 203:337-347.

von Meyenn, F., M. Schaefer, H. Weighardt, S. Bauer, C.J. Kirschning, H. Wagner, and T. Sparwasser. 2006. Toll-like receptor 9 contributes to recognition of Mycobacterium bovis Bacillus Calmette-Guerin by Flt3-ligand generated dendritic cells. Immunobiology 211:557-565.

 

2004

Sparwasser, T., S. Gong, J.Y. Li, and G. Eberl. 2004. General method for the modification of different BAC types and the rapid generation of BAC transgenic mice. Genesis 38:39-50.

 

2002

Jung, S., D. Unutmaz, P. Wong, G. Sano, K. De los Santos, T. Sparwasser, S. Wu, S. Vuthoori, K. Ko, F. Zavala, E.G. Pamer, D.R. Littman, and R.A. Lang. 2002. In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens. Immunity 17:211-220.

 

2001

Baribaud, F., S. Pohlmann, T. Sparwasser, M.T. Kimata, Y.K. Choi, B.S. Haggarty, N. Ahmad, T. Macfarlan, T.G. Edwards, G.J. Leslie, J. Arnason, T.A. Reinhart, J.T. Kimata, D.R. Littman, J.A. Hoxie, and R.W. Doms. 2001. Functional and antigenic characterization of human, rhesus macaque, pigtailed macaque, and murine DC-SIGN. J Virol 75:10281-10289.

 

2000

Arnold-Schrauf, C., L. Berod, and T. Sparwasser. 2015. Dendritic cell specific targeting of MyD88 signalling pathways in vivo. Eur J Immunol 45:32-39.

Berod, L., F. Puttur, J. Huehn, and T. Sparwasser. 2012. Tregs in infection and vaccinology: heroes or traitors? Microb Biotechnol 5:260-269.

 

1999

Sparwasser, T., L. Hultner, E.S. Koch, A. Luz, G.B. Lipford, and H. Wagner. 1999. Immunostimulatory CpG-oligodeoxynucleotides cause extramedullary murine hemopoiesis. J Immunol 162:2368-2374.

 

1998

Hacker, H., H. Mischak, T. Miethke, S. Liptay, R. Schmid, T. Sparwasser, K. Heeg, G.B. Lipford, and H. Wagner. 1998. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J 17:6230-6240.

Heeg, K., T. Sparwasser, G.B. Lipford, H. Hacker, S. Zimmermann, and H. Wagner. 1998. Bacterial DNA as an evolutionary conserved ligand signalling danger of infection to immune cells. Eur J Clin Microbiol Infect Dis 17:464-469.

Sparwasser, T., E.S. Koch, R.M. Vabulas, K. Heeg, G.B. Lipford, J.W. Ellwart, and H. Wagner. 1998. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur J Immunol 28:2045-2054.

 

1997

Lipford, G.B., T. Sparwasser, M. Bauer, S. Zimmermann, E.S. Koch, K. Heeg, and H. Wagner. 1997. Immunostimulatory DNA: sequence-dependent production of potentially harmful or useful cytokines. Eur J Immunol 27:3420-3426.

Sparwasser, T., T. Miethke, G. Lipford, K. Borschert, H. Hacker, K. Heeg, and H. Wagner. 1997. Bacterial DNA causes septic shock. Nature 386:336-337.

Sparwasser, T., T. Miethke, G. Lipford, A. Erdmann, H. Hacker, K. Heeg, and H. Wagner. 1997. Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-alpha-mediated shock. Eur J Immunol 27:1671-1679.

 

 

Preise und Auszeichnungen

2020

Call for a W2 professorship, Institute for Molecular Medicine

Dr. Luciana Berod

2020 to date

Member Senate Committee on Internationalization (JGU Mainz)

Prof. Dr. Tim Sparwasser

2019-2023

Member of the DGfI Advisory Board 2nd period of office

Prof. Dr. Tim Sparwasser

2019-2022

German representative of the International Council of Immunologists (IUIS)

Prof. Dr. Tim Sparwasser

2018 to date

Member Steering committee FZI (JGU Mainz)

Prof. Dr. Tim Sparwasser

2018

Call for a W3 professorship / Chair Institute for Medical Microbiology and Hygiene (IMMH), JGU Mainz

Prof. Dr. Tim Sparwasser

 

Robert Koch Postoctoral Prize in Immunology

Dr. Christian Thomas Mayer

 

Early Career Research Prize in Vaccinology (IUIS)

Dr. Christian Thomas Mayer

 

MHH HILF PostDoc Research Funding

Dr. Jenny Kühne

2018 to date

Associate Researcher Center for Research in Inflammatory Diseases – CRID Ribeirao Preto Medical School, University of Sao Paulo CRID Ribeirao Preto Medical School, University of Sao Paulo

Prof. Dr. Tim Sparwasser

2017

Call for a W3 professorship, Institute for Medical Microbiology and Virology, TU Dresden (declined)

Prof. Dr. Tim Sparwasser

 

MHH Promotion Award

Dr. Marc Lindenberg

 

DZIF MD-PhD Scholarship

Dr. Marc Lindenberg

2016

HZI Paper of the month

Marcela Francoso/ Dr. Franz Puttur

 

Lundbeck Award

Dr. Katharina Lahl

 

Jürgen-Wehland Award

Dr. Luciana Berod

 

DAAD Scholarship

Dr. Lis Velasquez

 

HZI Paper of the month

Markus Dudek

 

EMBO Scholarship

Dr. Carlos Bueno

 

DAAD Short-term Scholarship

Lais Sacramento

 

DAAD Short-term Scholarship

Paulo Melo

 

FAPESP Scholarship (Sabbatical)

Prof. Dr. Vania Bonato

2016 to date

Chairman DGfI Jury of Fritz -and Ursula Melcher Award

Prof. Dr. Tim Sparwasser

2016-2018

Member COALITION / CIIM (MHH)

Prof. Dr. Tim Sparwasser

2015

Ellen-Schmidt Habil. Scholarship

Dr. Luciana Berod

 

Boehringer Ingelheim Foundation

Lucia Minarrieta

 

DAAD Scholarship

Brenda Raud

 

Ragnar Söderberg Fellowship in Medicine

Dr. Katharina Lahl

 

EMBO Fellowship

Dr. Christian Thomas Mayer

2015-2018

Guest professor Microbiology and Infection Immunology, Facultad de Medicina, Universidad Catolica de Cordoba, Argentina

Prof. Dr. Tim Sparwasser

2014

Fritz- und Ursula Melchers DGfI Postdoc award

Dr. Christian Thomas Mayer

 

Poster award/ Travel grant (Seahorse)

Dr. Luciana Berod

 

HZI Paper of the month

Dr. Catharina Arnold-Schrauf

 

HZI Paper of the month

Peyman Ghorbani

 

HZI Paper of the month

Dr. Luciana Berod

 

MHH HILF PostDoc Research Funding

Dr. Luciana Berod

2014-2018

Member of the DGfI Advisory Board 1st period of office

Prof. Dr. Tim Sparwasser

2014-2018

Member of the International Council of Hannover Medical School

Prof. Dr. Tim Sparwasser

2013

HZI Inhoffen Award

Dr. Christian Thomas Mayer

 

MHH HILF PostDoc Research Funding

Dr. Franz Puttur

 

HZI Paper of the month

Dr. Franz Puttur

 

Ciência sem fronteiras CAPES Scholarship

Marcela Francozo

 

Fulbright Scholarship

Aline Sandouk

2012

TUI Habilitation Award

Dr. Matthias Lochner

2011

HZI Paper of the month

Dr. Matthias Lochner

2010

Boehringer Ingelheim Foundation PhD Fellowship

Catharina Arnold-Schrauf

 

DAAD PhD Fellowship

Amrita Nandan

2010-2019

Advisory Board Member of GRK 1660

Prof. Dr. Tim Sparwasser

2009

PhD Scholarship German National Academic Foundation

Christian Thomas Mayer

2009-2013

Board member of the Collaborative Research Center SFB 587

Prof. Dr. Tim Sparwasser

2008

Call for a W3 professorship for Infection Immunology (TWINCORE, a joint venture between Hannover Medical School and Helmholtz Center for Infection Research), Hannover

Prof. Dr. Tim Sparwasser

2007-2008

Board member of the TR 22

Prof. Dr. Tim Sparwasser

1999

DGHM Young Investigator Award (German Society of Microbiology & Hygiene)

Dr. Tim Sparwasser

1999-2002

HHMI Postdoctoral Fellowship Award for Physicians

Dr. Tim Sparwasser

1989-1995

Scholarship German National Academic Foundation

Tim Sparwasser

Alumni

 

Luís P Almeida
Master Thesis, Medizinische Biochemie, Deutsch-Argentinisches AMIBA Master Programm in Infektionsbiologie am TWINCORE/Medizinische Hochschule Hannover (MHH) (2019)
derzeitig: Doktorand, Immunparasitologie mit Maria Yazdanbakhsh, Leiden Universitätsklinikum, Leiden, Niederlande

Jon Arnason
DAAD Stipendium als “visiting student” (2002-2003)
danach: Mitarbeiter der Hämatologie und Onkologie, am Weill Cornell Medical Center New York
derzeitig: MD, Beth Israel Deaconess Medical Center of Boston, USA

Catharina Arnold-Schrauf
PhD Stipendiatin der Boehringer Ingelheim Stiftung (2010-2014); PhD am TWINCORE/MHH und Postdoktorandin SFB 900 (2014-2015)
danach: Postdoktorandin, Centre d’ Immunologie de Marseille mit Marc Dalod, Marseille, Frankreich
derzeitig: Medical Affairs Spezialist, Hämatologie/Onkologie bei Celgene in Wien, Österreich

Abdul Mannan Baru
Postdoktorand am TWINCORE/MHH (2009-2012)
danach: Postdoktorand  in Molekularer und Translationaler Kardiologie mit Kai C. Wollert
derzeitig: Wissenschaftlicher Leiter, GlaxoSmithKline Pharma GmbH, Stevenage, Vereinigtes Königreich

Luciana Berod
Postdoktorandin und Gruppenleiterin am TWINCORE, ein Verbund der MHH und dem Helmholtz Zentrum für Infektionsforschung (HZI) (2010-2020)
derzeitig: W2 Professorin am Institut für Molekulare Medizin, Universitätsmedizin, Johannes Gutenberg Universität Mainz

Carla Castro
Postdoktorandin am TWINCORE/MHH (2013-2016)
derzeitig: Postdoktorandin, Zentrum für Chronische Immundefizienz (CCI) mit Stephan Ehl, Universitätsmedizin Freiburg

Andrea Classen
Master Thesis, Biochemie an der LMU München (2003-2004)
derzeitig: Doktorandin, Makrophagen Biologie mit Antonio Celada, Institut für biomedizinische Forschung, Universität Barcelona, Spanien

Daniela Dittlein
Bachelor Thesis, Biochemie an der TU München (2007); Doktorand an der TUM
derzeitig: Wissenschaftlicher Berater des CEO, Helmholtz Zentrum München

Markus Dudek
PhD Stipendiat, IRTG 1273 (2011-2016); PhD am TWINCORE/MHH
danach: Postdoktorand am Zentrum für Thrombose und Hämostase (CTH) mit Markus Bosmann, Universitätsmedizin Mainz
derzeitig: Wissenschaftler, Translationale Biomarker, Sanofi, Frankfurt am Main

Theresa Förg
Medizinstudentin an der TU München (TUM)/TWINCORE (2009); Stipendiatin Studienstiftung des deutschen Volkes; MD an der TUM
derzeitig: Fachärztin, Pädiatrische Klinik und pädiatrische Poliklinik, LMU München

Marcela Francozo
DAAD/CAPES PhD Stipendiatin, Doktorandin (2013-2017) und Postdoktorandin am TWINCORE/MHH (2018-2019)
derzeitig: Stellvertretende Projektleiterin, Vakzine Project Management GmbH, Hannover

Christin Friedrich
Doktorandin, DFG gefördert, am TWINCORE/MHH (2011-2014)
danach: Postdoktorandin mit Georg Gasteiger an der Johannes Gutenberg-Universität Mainz
derzeitig: Postdoktorandin, Institut für Systemimmunologie mit Georg Gasteiger, Universität Würzburg

Venkateswaran Ganesh
PhD Stipendiat des Molecular Medicine PhD Programms (2009-2013); PhD am TWINCORE/MHH
danach: Wissenschaftler, Pfizer, Chennai, Indien
derzeitig: Stellvertretender Leiter, Programm Management, Biocon, Bengaluru Area, Indien

Maria Virginia Gentilini
Postdoktorandin SFB 900 (2015-2016)
derzeitig: Dozentin an der Universität Buenos Aires und Postdoktoranden Stipendiatin, CONICET, Universitätsklinikum  "José de San Martín" in Buenos Aires, Argentinien

Peyman Ghorbani
Doktorand, Zentrum für Infektionsbiologie (ZIB), PhD am TWINCORE/MHH (2012-2017)
derzeitig: Postdoktorand, Ottawa Universität mit Morgan Fullerton, Kanada

Wiebke Ginter
PhD Stipendiatin, Zentrum für Infektionsbiologie (ZIB) (2009-2013); PhD am TWINCORE/MHH
danach: Wissenschaftliche Koordinatorin der LISA Sommer Akademie und dem AMIBA Master Program
derzeitig: Referentin der Deutsche Forschungsgemeinschaft (DFG), Bonn

Naghmeh Goharani
Medizinstudentin, “StrucMed” TWINCORE/MHH (2012-2014); MD an der MHH

Stefanie Hagemann
PhD Stipendiatin KFO250 (2010-2013); PhD am TWINCORE/MHH
derzeitig: Postdoktorandin mit Siegfried Hapfelmeier am Institut für Infektionskrankheiten, Universität Bern, Schweiz

Andrea Hartl
Doktorandin in Biologie (2004-2009) und PhD an der TU München
derzeitig: Teamleiterin Kriminalität/Projektleiterin/LIMS-Administratorin, Eurofins Medigenomix Forensik GmbH, Ebersberg

Karen Patricia Hartmann
Studentische Hilfskraft (2013-2014); Bachelor Thesis, Biomedizin an der Leibniz Universität Hannover und dem TWINCORE (2013-2013)
danach: Mitarbeiterin am Paul-Ehrlich-Institut in Langen, Molekulare Biotechnologie und Gentherapie mit Christian Buchholz

derzeitig: Doktorandin an der Universität Zürich, Abteilung für Biochemie, Zürich, Schweiz

Siona Hauer
Medizindoktorandin, StrucMed/MHH (2010-2011); MD an der MHH

Christina Hesse
PhD Stipendiatin der International Research Training Groups 1441 (2010-2014); PhD und Postdoktorandin am TWINCORE/MHH (2015)
danach: Postdoktorandin Fraunhofer mit Armin Braun am Institut für Toxikologie und Experimentelle Medizin (ITEM)
derzeitig: Gruppenleiterin „Respiratory Pharmcology“, Abteilung für präklinische Pharmakologie und In-Vitro-Toxikologie am ITEM, Hannover

Susanne Hipp
Bachelor Thesis, Biochemie an der TU München (2004)

Julia Huntenburg
Bachelor Thesis, Life Sciences an der Leibnitz Universität Hannover und am TWINCORE/MHH, Stipendiatin Studienstiftung des Deutschen Volkes (2010)
danach: Master Programm Molekulare Medizin, Charité Berlin
derzeitig: Doktorandin am Max-Planck Institut für Kognitions- und Gehirnwissenschaften des Menschen, Leipzig

Inga Jensch
Master Thesis, Biologie an der TU München (2004-2005); PhD in Mikrobiologie mit Sven Hammerschmidt, Universität Greifswald
derzeitig: Postdoktorandin mit Matthias Hundt an dem ZIK HIKE, Universität Greifswald

Stefan Jordan
Master Thesis, Biochemie der TU München (2006); Stipendiat der Studienstiftung des deutschen Volkes; PhD mit Ulrich Koszinowski, Max von Pettenkofer-Institut an der LMU
danach: Postdoktorand mit Miriam Merad, Medizinische Hochschule New York Mount Sinai, USA
derzeitig: Gruppenleiter, Institut für Mikrobiologie und Infektionsimmunologie, Charité Berlin

Wilhelm Korte
Medizindoktorand, StrucMed/MHH (2011-2012)
zuletzt: Assistenzarzt in der Herzchirurgie an der MHH

Freyja Kull
Medizinstudentin, StrucMed/MHH (2013)

Katharina Lahl
Diplomarbeit (2004-2005) und Doktorandin an der TU München (2005-2009)
danach: Postdoktorandin, Stanford Universität mit Eugene Butcher, Palo Alto, USA
derzeitig: Gruppenleiterin und außerordentlicher Professor, DTU Health Tech, Technische Universität Dänemark und Abteilung für Virus Erkennung, Lund Universität, Schweden

Marc Lindenberg
Doktorand (2012-2013); MD/PhD an der MHH (2018-2020)

Matthias Lochner
Gruppenleiter, dann Außerordentlicher Professor (PD) am TWINCORE/MHH (2010-2020), derzeitig: Außerordentlicher Professor an der Abteilung für Medizinische Mikrobiologie, MHH

Christian Mayer
Master Thesis, Biochemie an der TU München (2007-2008), PhD Stipendiat Studienstiftung des deutschen Volkes, PhD (2008-2012) und Postdoktorand am TWINCORE/MHH (2012-2013)
danach: Postdoktorand mit Michel Nussenzweig, Rockefeller Universität, New York, USA
derzeitig: NIH Forscher in der Experimentellen Immunologie, Nationales Krebsinstitut, Bethesda, USA

Lucia Minarrieta
PhD Stipendiatin der Boehringer Ingelheim Stiftung, Doktorandin, Zentrum für Infektiöse Biologie (ZIB) am TWINCORE/MHH (2014-2018)
derzeitig: Postdoktorandin mit Julie St-Pierre, Universität Ottawa, Kanada

Mercedes Muske
Master Thesis am TWINCORE/MHH (2014-2015)

Amrita Nandan
DAAD PhD Stipendiatin, PhD at MHH (2010-2014)
derzeitig: Wissenschaftlerin, Institut für Genomik und Integrative Biologie (IGIB), CSIR, Indien

Franz Puttur
Postdoktorand am TWINCORE/MHH (2010-2016)
derzeitig: Postdoktorand am Imperial College, Nationales Herz- und Lungen Institut mit Clare Lloyd, Medizinische Fakultät, in London, Vereinigtes Königreich

Brenda Raud
DAAD PhD Stipendiatin, Doktorandin am TWINCORE/MHH (2014-2018)
derzeitig: Postdoktorandin mit John Haanen, Abteilung für Molekulare Onkologie und Immunologie, Niederländisches Krebs-Institut, Amsterdam, Niederlande

Martin Schäfer
Doktorand in Biologie an der TU München (2003-2006); PhD an der TU München
derzeitig: Wissenschaftler in Bioanalytik, Roche Diagnostics GmbH in Penzberg

Gülhas Solmaz
PhD Stipendiatin Zentrum für Infektionsbiologie (ZIB) (2011-2016); PhD am TWINCORE/MHH
zuletzt: Postdoktorandin mit Fahrettin Kelestemur am Türkischen Gesundheitsministerium, Ankara, Türkei

Johannes Stephani
Medizinstudent an der TU München (2006-2008); MD an der TU München
derzeitig: Innere Medizin, Universitätsklinikum Ulm

Philipp Stüve
Master Thesis (2013) und PhD (2013-2017) am TWINCORE/MHH
derzeitig: Postdoktorand am IMMH, Universitätsmedizin, Johannes Gutenberg Universität Mainz

Lena Thöle
Master Thesis, Biochemie am TWINCORE/MHH, Stipendiatin Studienstiftung des deutschen Volkes (2016)
derzeitig: Medizinstudentin an der MHH

Christopher Untucht
Postdoktorand (2011-2012)
danach: Postdoktorand bei AbbVie Germany GmbH & Co KG
derzeitig: Leitender Wissenschaftler II Abbvie, Ludwigshafen

Christopher van Helt
Master Thesis, Biomedizin am TWINCORE/MHH (2010)
danach: Doktorand bei Beiersdorf, Abteilung Experimentelle Toxikologie
derzeitig: QA Manager Release, Sandoz, Österreich

Ferdinand von Meyenn
Master Thesis, Biochemie - TU München (2005-2006); PhD, Institut für Molekulare Systembiologie mit Markus Stoffel, ETH Zürich
danach: Postdoktorand mit Wolfgang Reik, Universität Cambridge
derzeitig: Assistenz-Professor, Labor für Ernährung und metabolische Epigenetik, ETH Zürich, DHEST, Österreich

Zuobai Wang
PhD Stipendiat am Zentrum für Infektionsbiologie (2010-2014); PhD am TWINCORE/MHH
derzeitig: Postdoktorand bei BeiGene, Beijing, China

Vera Wenzel
Bachelor Thesis -TU München (2007); Doktorandin an der TU München
derzeitig: Medical Lead Education Solutions, coliquio

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