Visual Universitätsmedizin Mainz

Publikationen des Instituts für Mikrobiologie und Hygiene



Miyanagal N, Takagil H, Uto1 T, Fukaya1 T, Nasu1 J, Fukui1 T, Nishikawa1 Y, Sparwasser T, Choijookhuu N, Hishikawa Y, Nakamura T, Tono T & Sato K. Essential role of submandibular lymph node dendritic cells in protective sublingual immunotherapy against murine allergy. Communications Biology (in press)

Almeida, L., A. Dhillon-LaBrooy, C.N. Castro, N. Adossa, G.M. Carriche, M. Guderian, S. Lippens, S. Dennerlein, C. Hesse, B.N. Lambrecht, L. Berod, L. Schauser, B.R. Blazar, M. Kalesse, R. Muller, L.F. Moita, and T. Sparwasser. 2020. Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis. Immunity

Besemer, A.S., J. Maus, M.D.A. Ax, A. Stein, S. Vo, C. Freese, K. Nalbach, C. von Hilchen, I.F. Pfalzgraf, I. Koziollek-Drechsler, B. Silva, H. Huesmann, F. Boukhallouk, L. Florin, A. Kern, C. Behl, and A.M. Clement. 2020. Receptor-mediated endocytosis 8 (RME-8)/DNAJC13 is a novel positive modulator of autophagy and stabilizes cellular protein homeostasis. Cell Mol Life Sci

Gamrekelashvili J., Kapanadze T., Sablotny S., Ratiu C., Dastagir K., Lochner M., Karbach S., Wenzel P., Sitnow A., Fleig S., Sparwasser T., Kalinke U., Holzmann B., Haller H., Limbourg F.P.. 2020 Notch and TLR signaling coordinate monocyte cell fate and inflammation. Elife; 9.

Einwaechter H., Heiseke A., Schlitzer A., Gasteiger G., Adler H., Voehringer D., Manz M.G., Ruzsics Z., Doelken L., Koszinowski U.H., Sparwasser T., Reindl W., Jordan S.. 2020. The Innate Immune Response to Infection Induces Erythropoietin-Dependent Replenishment of the Dendritic Cell Compartment. Frontiers in Immunology; 11.

Carriche, G.M., L. Almeida, P. Stuve, L. Velasquez, A. Dhillon-LaBrooy, U. Roy, M. Lindenberg, T. Strowig, C. Plaza-Sirvent, I. Schmitz, M. Lochner, A.K. Simon, and T. Sparwasser. 2020. Regulating T cell differentiation through the polyamine spermidine. J Allergy Clin Immunol

Heinrich, S., V. Tripke, T. Huber, E. Siegel, M. Dennebaum, L. Staib, M.A. Worns, K. Oberholzer, J. Mittler, and H. Lang. 2020. [Results of multimodal treatment of hepatic echinococcosis]. Chirurg

Langenwalder, D.B., S. Schmidt, C. Silaghi, J. Skuballa, N. Pantchev, I.A. Matei, A.D. Mihalca, U. Gilli, J. Zajkowska, M. Ganter, T. Hoffman, E. Salaneck, M. Petrovec, and F.D. von Loewenich. 2020. The absence of the drhm gene is not a marker for human-pathogenicity in European Anaplasma phagocytophilum strains. Parasit Vectors 13:238.

Langenwalder, D.B., C. Silaghi, M. Nieder, M. Pfeffer, and F.D. von Loewenich. 2020. Co-infection, reinfection and superinfection with Anaplasma phagocytophilum strains in a cattle herd based on ankA gene and multilocus sequence typing. Parasit Vectors 13:157.

Mamareli, P., F. Kruse, C.W. Lu, M. Guderian, S. Floess, K. Rox, D.S.J. Allan, J.R. Carlyle, M. Bronstrup, R. Muller, L. Berod, T. Sparwasser*, and M. Lochner. 2020*. Targeting cellular fatty acid synthesis limits T helper and innate lymphoid cell function during intestinal inflammation and infection. Mucosal Immunol. *equally contributed

Mesquita, I., C. Ferreira, D. Moreira, G.E.G. Kluck, A.M. Barbosa, E. Torrado, R.J. Dinis-Oliveira, L.G. Goncalves, C.J. Beauparlant, A. Droit, L. Berod, T. Sparwasser, N. Bodhale, B. Saha, F. Rodrigues, C. Cunha, A. Carvalho, A.G. Castro, J. Estaquier, and R. Silvestre. 2020. The Absence of HIF-1alpha Increases Susceptibility to Leishmania donovani Infection via Activation of BNIP3/mTOR/SREBP-1c Axis. Cell Rep 30:4052-4064 e4057.

Moye, S., T. Bormann, R. Maus, T. Sparwasser, I. Sandrock, I. Prinz, G. Warnecke, T. Welte, J. Gauldie, M. Kolb, and U.A. Maus. 2020. Regulatory T Cells Limit Pneumococcus-Induced Exacerbation of Lung Fibrosis in Mice. J Immunol 204:2429-2438.

Mukhacheva, T.A., D.R. Shaikhova, S.Y. Kovalev, and F.D. von Loewenich. 2020. Phylogeographical diversity of Anaplasma phagocytophilum in the Asian part of Russia based on multilocus sequence typing and analysis of the ankA gene. Infect Genet Evol 80:104234.

Sacramento, L.A., L. Benevides, S.R. Maruyama, L. Tavares, K.F. Fukutani, M. Francozo, T. Sparwasser, F.Q. Cunha, R.P. Almeida, J.S. da Silva, and V. Carregaro. 2020. TLR4 abrogates the Th1 immune response through IRF1 and IFN-beta to prevent immunopathology during L. infantum infection. PLoS Pathog 16:e1008435.

Witkowski, M., M. Witkowski, M. Saffarzadeh, J. Friebel, T. Tabaraie, L. Ta Bao, A. Chakraborty, A. Dorner, B. Stratmann, D. Tschoepe, S.J. Winter, A. Krueger, W. Ruf, U. Landmesser, and U. Rauch. 2020. Vascular miR-181b controls tissue factor-dependent thrombogenicity and inflammation in type 2 diabetes. Cardiovasc Diabetol 19:20.



Ahmetlic, F., T. Riedel, N. Homberg, V. Bauer, N. Trautwein, A. Geishauser, T. Sparwasser, S. Stevanovic, M. Rocken, and R. Mocikat. 2019. Regulatory T Cells in an Endogenous Mouse Lymphoma Recognize Specific Antigen Peptides and Contribute to Immune Escape. Cancer Immunol Res 7:600-608.

Almeida, L., A. Dhillon-LaBrooy, C.N. Castro, N. Ayele, J. Bartel, G.M. Carriche, M. Guderian, S. Lippens, S. Dennerlein, C. Hesse, B.N. Lambrecht, L. Schauser, B.R. Blazar, M. Kalesse, R. Müller, L.F. Moita and T.Sparwasser. 2019. Ribosome-targeting antibiotics impair T cell effector function and ameliorate autoimmunity by blocking mitochondrial protein synthesis. BioRxiv 832956.

Al Nabhani, Z., S. Dulauroy, R. Marques, C. Cousu, S. Al Bounny, F. Dejardin, T. Sparwasser, M. Berard, N. Cerf-Bensussan, and G. Eberl. 2019. A Weaning Reaction to Microbiota Is Required for Resistance to Immunopathologies in the Adult. Immunity 50:1276-1288 e1275.

Andersen, L., A.F. Gulich, M. Alteneder, T. Preglej, M.J. Orola, N. Dhele, V. Stolz, A. Schebesta, P. Hamminger, A. Hladik, S. Floess, T. Krausgruber, T. Faux, S.B.A. Andrabi, J. Huehn, S. Knapp, T. Sparwasser, C. Bock, A. Laiho, L.L. Elo, O. Rasool, R. Lahesmaa, S. Sakaguchi, and W. Ellmeier. 2019. The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3(+) Regulatory T Cells. Cell Rep 29:4447-4459 e4446.

Gronke, K., P.P. Hernandez, J. Zimmermann, C.S.N. Klose, M. Kofoed-Branzk, F. Guendel, M. Witkowski, C. Tizian, L. Amann, F. Schumacher, H. Glatt, A. Triantafyllopoulou, and A. Diefenbach. 2019. Interleukin-22 protects intestinal stem cells against genotoxic stress. Nature 566:249-253.

Ichikawa, T., K. Hirahara, K. Kokubo, M. Kiuchi, A. Aoki, Y. Morimoto, J. Kumagai, A. Onodera, N. Mato, D.J. Tumes, Y. Goto, K. Hagiwara, Y. Inagaki, T. Sparwasser, K. Tobe, and T. Nakayama. 2019. CD103(hi) Treg cells constrain lung fibrosis induced by CD103(lo) tissue-resident pathogenic CD4 T cells. Nat Immunol 20:1469-1480.

Langenwalder, D.B., S. Schmidt, U. Gilli, N. Pantchev, M. Ganter, C. Silaghi, M.L. Aardema, and F.D. von Loewenich. 2019. Genetic characterization of Anaplasma phagocytophilum strains from goats (Capra aegagrus hircus) and water buffalo (Bubalus bubalis) by 16S rRNA gene, ankA gene and multilocus sequence typing. Ticks Tick Borne Dis 10:101267.

Mamareli, P., F. Kruse, C. Friedrich, N. Smit, T. Strowig, T. Sparwasser, and M. Lochner. 2019. Epithelium-specific MyD88 signaling, but not DCs or macrophages, control acute intestinal infection with Clostridium difficile. Eur J Immunol 49:747-757.

Menzer, C., A.M. Menzies, M.S. Carlino, I. Reijers, E.J. Groen, T. Eigentler, J.W.B. de Groot, A.A.M. van der Veldt, D.B. Johnson, F. Meiss, M. Schlaak, B. Schilling, H.M. Westgeest, R. Gutzmer, C. Pfohler, F. Meier, L. Zimmer, K.P.M. Suijkerbuijk, T. Haalck, K.M. Thoms, K. Herbschleb, J. Leichsenring, A. Menzer, A. Kopp-Schneider, G.V. Long, R. Kefford, A. Enk, C.U. Blank, and J.C. Hassel. 2019. Targeted Therapy in Advanced Melanoma With Rare BRAF Mutations. J Clin Oncol 37:3142-3151. 

Mikulicic, S., J. Finke, F. Boukhallouk, E. Wustenhagen, D. Sons, Y. Homsi, K. Reiss, T. Lang, and L. Florin. 2019. ADAM17-dependent signaling is required for oncogenic human papillomavirus entry platform assembly. Elife 8:

Rosch, R.M., K. Buschmann, L. Brendel, T. Schwanz, and C.F. Vahl. 2019. Lactococcus garvieae Endocarditis in a Prosthetic Aortic Valve: A Case Report and Literature Review. J Investig Med High Impact Case Rep 7:2324709619832052.

Schmeh, I., A. Kidszun, A. Welk, T. Schwanz, B. Jansen, and E. Mildenberger. 2019. Evaluation of microbiological screening in a neonatal intensive care unit to optimize empiric antibiotic use. J Hosp Infect 101:362-364.

Schmidleithner, L., Y. Thabet, E. Schonfeld, M. Kohne, D. Sommer, Z. Abdullah, T. Sadlon, C. Osei-Sarpong, K. Subbaramaiah, F. Copperi, K. Haendler, T. Varga, O. Schanz, S. Bourry, K. Bassler, W. Krebs, A.E. Peters, A.K. Baumgart, M. Schneeweiss, K. Klee, S.V. Schmidt, S. Nussing, J. Sander, N. Ohkura, A. Waha, T. Sparwasser, F.T. Wunderlich, I. Forster, T. Ulas, H. Weighardt, S. Sakaguchi, A. Pfeifer, M. Bluher, A.J. Dannenberg, N. Ferreiros, L.J. Muglia, C. Wickenhauser, S.C. Barry, J.L. Schultze, and M. Beyer. 2019. Enzymatic Activity of HPGD in Treg Cells Suppresses Tconv Cells to Maintain Adipose Tissue Homeostasis and Prevent Metabolic Dysfunction. Immunity 50:1232-1248 e1214.

Serradell, M.C., L.L. Rupil, R.A. Martino, C.G. Prucca, P.G. Carranza, A. Saura, E.A. Fernandez, P.R. Gargantini, A.H. Tenaglia, J.P. Petiti, R.R. Tonelli, N. Reinoso-Vizcaino, J. Echenique, L. Berod, E. Piaggio, B. Bellier, T. Sparwasser, D. Klatzmann, and H.D. Lujan. 2019. Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins. Nat Commun 10:361.

Siemer, S., D. Westmeier, M. Barz, J. Eckrich, D. Wunsch, C. Seckert, C. Thyssen, O. Schilling, M. Hasenberg, C. Pang, D. Docter, S.K. Knauer, R.H. Stauber, and S. Strieth. 2019. Biomolecule-corona formation confers resistance of bacteria to nanoparticle-induced killing: Implications for the design of improved nanoantibiotics. Biomaterials 192:551-559.

Solmaz, G., F. Puttur, M. Francozo, M. Lindenberg, M. Guderian, M. Swallow, V. Duhan, V. Khairnar, U. Kalinke, B. Ludewig, B.E. Clausen, H. Wagner, K.S. Lang, and T.D. Sparwasser. 2019. TLR7 Controls VSV Replication in CD169(+) SCS Macrophages and Associated Viral Neuroinvasion. Front Immunol 10:466.

Tegtmeyer, P., M. Ganter, and F.D. von Loewenich. 2019. Simultaneous infection of cattle with different Anaplasma phagocytophilum variants. Ticks Tick Borne Dis 10:1051-1056.

von Hoven, G., and M. Husmann. 2019. Staphylococcus aureus alpha-Toxin's Close Contacts Ensure the Kill. Trends Microbiol 27:89-90.

von Hoven, G., Q. Qin, C. Neukirch, M. Husmann, and N. Hellmann. 2019. Staphylococcus aureus alpha-toxin: small pore, large consequences. Biol Chem 400:1261-1276.

von Hoven, G., A.J. Rivas, and M. Husmann. 2019. Phobalysin: Fisheye View of Membrane Perforation, Repair, Chemotaxis and Adhesion. Toxins (Basel) 11:

von Loewenich, F.D., C. Seckert, E. Dauber, M.J.L. Kik, A. de Vries, H. Sprong, K. Buschmann, M.L. Aardema, and M. Brandstetter. 2019. Prosthetic Valve Endocarditis with Bartonella washoensis in a Human European Patient and Its Detection in Red Squirrels (Sciurus vulgaris). J Clin Microbiol 58:

Wang, Y., K. Dembowsky, E. Chevalier, P. Stuve, M. Korf-Klingebiel, M. Lochner, L.C. Napp, H. Frank, E. Brinkmann, A. Kanwischer, J. Bauersachs, M. Gyongyosi, T. Sparwasser, and K.C. Wollert. 2019. C-X-C Motif Chemokine Receptor 4 Blockade Promotes Tissue Repair After Myocardial Infarction by Enhancing Regulatory T Cell Mobilization and Immune-Regulatory Function. Circulation 139:1798-1812.



Adomavicius, D., M. Bock, C.F. Vahl, and E. Siegel. 2018. Aerococcus urinae Mitral Valve Endocarditis-Related Stroke: A Case Report and Literature Review. J Investig Med High Impact Case Rep 6:2324709618758351.

Almeida, F.F., S. Tognarelli, A. Marcais, A.J. Kueh, M.E. Friede, Y. Liao, S.N. Willis, K. Luong, F. Faure, F.E. Mercier, J. Galluso, M. Firth, E. Narni-Mancinelli, B. Rais, D.T. Scadden, F. Spallotta, S. Weil, A. Giannattasio, F. Kalensee, T. Zoller, N.D. Huntington, U. Schleicher, A.G. Chiocchetti, S. Ugolini, M.J. Herold, W. Shi, J. Koch, A. Steinle, E. Vivier, T. Walzer, G.T. Belz, and E. Ullrich. 2018. A point mutation in the Ncr1 signal peptide impairs the development of innate lymphoid cell subsets. Oncoimmunology 7:e1475875.

Beger, B., F. von Loewenich, E. Goetze, M. Moergel, and C. Walter. 2018. Leech related Aeromonas veronii complex infection after reconstruction with a microvascular forearm flap. J Maxillofac Oral Surg 17:68-70.

Beilenhoff, U., H. Biering, R. Blum, J. Brljak, M. Cimbro, J.M. Dumonceau, C. Hassan, M. Jung, B. Kampf, C. Neumann, M.Pietsch, L. Pineau, T. Ponchon, S. Rejchrt, J.F. Rey, V. Schmidt, J. Tillett, and J.E. van Hooft. 2018. Reprocessing of flexible endoscopes and endoscopic accessories used in gastrointestinal endoscopy: Position Statement of the European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Gastroenterology Nurses and Associates (ESGENA) - Update 2018. Endoscopy 50:1205-1234.

Byrd, T.T., K. Fousek, A. Pignata, C. Szot, H. Samaha, S. Seaman, L. Dobrolecki, V.S. Salsman, H.Z. Oo, K. Bielamowicz, D. Landi, N. Rainusso, J. Hicks, S. Powell, M.L. Baker, W.S. Wels, J. Koch, P.H. Sorensen, B. Deneen, M.J. Ellis, M.T. Lewis, M. Hegde, B.S. Fletcher, B. St Croix, and N. Ahmed. 2018. TEM8/ANTXR1-Specific CAR T Cells as a Targeted Therapy for Triple-Negative Breast Cancer. Cancer Res 78:489-500.

Divakaruni, A.S., W.Y. Hsieh, L. Minarrieta, T.N. Duong, K.K.O. Kim, B.R. Desousa, A.Y. Andreyev, C.E. Bowman, K. Caradonna, B.P. Dranka, D.A. Ferrick, M. Liesa, L. Stiles, G.W. Rogers, D. Braas, T.P. Ciaraldi, M.J. Wolfgang, T. Sparwasser, L. Berod, S.J. Bensinger, and A.N. Murphy. 2018. Etomoxir Inhibits Macrophage Polarization by Disrupting CoA Homeostasis. Cell Metab 28:490-503 e497.

Doring, T., L. Zeyen, C. Bartusch, and R. Prange. 2018. Hepatitis B Virus Subverts the Autophagy Elongation Complex Atg5-12/16L1 and Does Not Require Atg8/LC3 Lipidation for Viral Maturation. J Virol 92:

Florin, L., and T. Lang. 2018. Tetraspanin Assemblies in Virus Infection. Front Immunol 9:1140.

Hacker, B., C. Schultheiss, M. Doring, and U. Kurzik-Dumke. 2018. Molecular partners of hNOT/ALG3, the human counterpart of the Drosophila NOT and yeast ALG3 gene, suggest its involvement in distinct cellular processes relevant to congenital disorders of glycosylation, cancer, neurodegeneration and a variety of further pathologies. Hum Mol Genet 27:1858-1878.

Hacker, B., C. Schultheiss, and U. Kurzik-Dumke. 2018. Sequential cleavage of the proteins encoded by HNOT/ALG3, the human counterpart of the Drosophila NOT and yeast ALG3 gene, results in products acting in distinct cellular compartments. Hum Mol Genet 27:4231-4248.

Hartmann, J., R.C. Munch, R.T. Freiling, I.C. Schneider, B. Dreier, W. Samukange, J. Koch, M.A. Seeger, A. Pluckthun, and C.J. Buchholz. 2018. A Library-Based Screening Strategy for the Identification of DARPins as Ligands for Receptor-Targeted AAV and Lentiviral Vectors. Mol Ther Methods Clin Dev 10:128-143.

Hernandez, P., K. Gronke, and A. Diefenbach. 2018. A catch-22: Interleukin-22 and cancer. Eur J Immunol 48:15-31.

Herrtwich, L., I. Nanda, K. Evangelou, T. Nikolova, V. Horn, Sagar, D. Erny, J. Stefanowski, L. Rogell, C. Klein, K. Gharun, M. Follo, M. Seidl, B. Kremer, N. Munke, J. Senges, M. Fliegauf, T. Aschman, D. Pfeifer, S. Sarrazin, M.H. Sieweke, D. Wagner, C. Dierks, T. Haaf, T. Ness, M.M. Zaiss, R.E. Voll, S.D. Deshmukh, M. Prinz, T. Goldmann, C. Holscher, A.E. Hauser, A.J. Lopez-Contreras, D. Grun, V. Gorgoulis, A. Diefenbach, P. Henneke, and A. Triantafyllopoulou. 2018. DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas. Cell 174:1325-1326.

Kerz, T., F.D. von Loewenich, J. Roberts, A. Neulen, and F. Ringel. 2018. Cerebrospinal fluid penetration of very high-dose meropenem: a case report. Ann Clin Microbiol Antimicrob 17:47.

Kramer, J., K. Triantafyllias, W. Kohnen, M. Leber, U. Dederichs-Masius, A. Zucker, J. Korber, and A. Schwarting. 2018. Patients with Rheumatic Diseases do not have an Increased Risk of MRSA Carrier Status. Rheumatol Ther 5:371-381.

Memmer, S., S. Weil, and J. Koch. 2018. Reconstitution of a ligand-binding competent murine NKp30 receptor. Immunogenetics 70:185-194.

Takemura, N., Y. Kurashima, Y. Mori, K. Okada, T. Ogino, H. Osawa, H. Matsuno, L. Aayam, S. Kaneto, E.J. Park, S. Sato, K. Matsunaga, Y. Tamura, Y. Ouchi, Y. Kumagai, D. Kobayashi, Y. Suzuki, Y. Yoshioka, J. Nishimura, M. Mori, K.J. Ishii, M.E. Rothenberg, H. Kiyono, S. Akira, and S. Uematsu. 2018. Eosinophil depletion suppresses radiation-induced small intestinal fibrosis. Sci Transl Med 10:

von Hoven, G., C. Neukirch, M. Meyenburg, S. Schmidt, A. Vences, C.R. Osorio, M. Husmann, and A.J. Rivas. 2018. Cytotoxin- and Chemotaxis-Genes Cooperate to Promote Adhesion of Photobacterium damselae subsp. damselae. Front Microbiol 9:2996.

Wanke, F., Y. Tang, K. Gronke, S. Klebow, S. Moos, J. Hauptmann, A. Shanmugavadivu, T. Regen, I.A. Mufazalov, L.A. Gabriel, S. Reissig, A. Diefenbach, F.C. Kurschus, and A. Waisman. 2018. Expression of IL-17F is associated with non-pathogenic Th17 cells. J Mol Med (Berl) 96:819-829.

Weiss, E., D. Hanzelmann, B. Fehlhaber, A. Klos, F.D. von Loewenich, J. Liese, A. Peschel, and D. Kretschmer. 2018. Formyl-peptide receptor 2 governs leukocyte influx in local Staphylococcus aureus infections. FASEB J 32:26-36.

Witkowski, M., M. Witkowski, N. Gagliani, and S. Huber. 2018. Recipe for IBD: can we use food to control inflammatory bowel disease? Semin Immunopathol 40:145-156.

Wu, Z.Y., S.P. Ho, J.F. Cheng, K.C. Tung, Y.K. Hong, S.Y. Chen, A. Menzer, Y.J. Chen, Y.T. Huang, and P.Y. Liu. 2018. Whole-genome characterization of Shewanella algae strain SYT3 isolated from seawater reveals insight into hemolysis. Future Microbiol 13:1709-1717.

Wustenhagen, E., F. Boukhallouk, I. Negwer, K. Rajalingam, F. Stubenrauch, and L. Florin. 2018. The Myb-related protein MYPOP is a novel intrinsic host restriction factor of oncogenic human papillomaviruses. Oncogene 37:6275-6284.