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TRP X10 Thrombotic Thrombocytopenic Purpura

Funding period: 01.09.2015 – 31.08.2018

Project Summary

The project aims at setting up a prospective observational cohort of patients with acquired thrombotic thrombocytopenic purpura (TTP). Patient data and biomaterial will be filed in a registry with professional database and biodata-banking for further research. Clinical questions will be addressed such as triggering mechanisms, clinical presentation, response to treatment and, especially, recurrence during long-term follow-up. New diagnostic methods will be developed and established (e.g. a flow-based ADAMTS13 assay) and laboratory research into the pathophysiology of TTP will be performed. We hope to gain new insights into the pathophysiology, diagnostic algorithms, treatment options and clinical outcome of this rare disease. Evidence-based recommendations for care givers and patients will be developed.

Besides publication in the scientific literature, our patients attending the yearly meeting of the German TTP Patient Association organized by the UMC in Mainz will be informed on important new knowledge gained. We aim to collaborate with other centers and to enroll their patients into the prospective registry in order to improve the significance of the new insights.

Principle Investigators

Charis von Auer, MD

Specialist in Internal Medicine, Haematology and Oncology, Haemostaseology



06131 17-5936

MD Professor Bernhard Lämmle
MD Professor Bernhard Lämmle

Guest Professor CTH, Emeritus Professor and Director of Hematology, University of Bern


Student assistant

Lucas Bach 

Collaboration Partners

PD Dr. Kerstin Jurk

PD Dr. Heidi Rossmann

Dr. Tanja Falter

Dr. Alice Trinchero

Prof. Philipp Wild

Prof. Harald Binder

Senior Consultant

Prof. Inge Scharrer

External Collaboration Partners

Prof. Johanna Kremer Hovinga, Bern

Prof. Paul Knöbl, Wien


  • von Auer C, von Krogh AS, Kremer Hovinga JA, Lämmle B (2015) Current insights into thrombotic microangiopathies: Thrombotic thrombocytopenic purpura and pregnancy. Thrombosis research 135 Suppl 1: S30-3


ADAMTS13 - Biology and Disease

Editor: George M. Rodgers

Springer Verlag

Chapter 1: History of Thrombotic Thrombocytopenic Purpura and the von Willebrand Factor–Cleaving Protease, ADAMTS13

B. Lämmle, C. von Auer