English
Dr. med. Susanne Helena Karbach
Oberärztin Kardiologie I, Projektleiterin
Lebenslauf
Since 2016 | Senior physician; Center of Cardiology – Cardiology I, University Medical Center Mainz (Prof. Dr. med. Th. Münzel) |
2015 | Board Exam Internal Medicine |
2010-2012 | Research Fellowship in the Institute of Molecular Medicine, University Medical Center Mainz (Prof. Ari Waisman); Research fellowship Margarethe-Waitz-Foundation |
2008-2015 | Residency in internal medicine / cardiology; Center of Cardiology – Cardiology I, University Medical Center Mainz (Prof. Dr. med. Th. Münzel) |
2003-2005 | Doctoral degree in Medical Sciences (Dr. med.), supervision by Prof. Dr. rer. nat. E. Closs und Prof. Dr. med. U. Förstermann, Department of Pharmacology, Johannes Gutenberg-Universität Mainz, Germany (Summa cum laude); Research fellowship Robert-Müller-Foundation |
2000-2007 | Medical student, Johannes Gutenberg-Universität Mainz, Germany, University Medical Center Örebro, Sweden and Université de Bourgogne, Dijon, France |
2000 | German high school diploma, Eduard-Spranger Gymnasium Landau/Pfalz, Germany |
Auszeichnungen
2015 | Boehringer-Ingelheim Award |
2013 | Pre-clinical Award of the Foundation Mainzer Herz |
2000 | Award for the best high school diploma of the school and for excellent performance in modern languages (French and English) |
Drittmittel
2017-2020 | Research Consortium Grant of the Boehringer Ingelheim Foundation: Novel and neglected cardiovascular risk factors – Molecular mechanisms and therapeutic implications. Project 3: Impact of skin inflammation on cardiovascular health. |
2015-2017 | Scientific Funding by the Translational Research Program (Project X.II) CTH Mainz, BMBF: Interleukin-6 in the development of venous thrombosis. |
Since 2014 | Grant of the German Research Foundation (KA 4035/1-1): The role of interleukin-6 (IL-6) and the interaction between IL-6 and interleukin-17 (IL-17) in the development of vascular inflammation and vascular dysfunction. |
2012-2014 | Research Funding of the Inneruniversitäre Forschungsförderung, University Medical Center Mainz: Influence of vascular function by deletion of the Interleukin-6 Receptor alpha on myelomonocytic cells and CD4+ T cells in mice. |
2010-2012 | MAIFOR Research Funding, University Medical Center Mainz: The role of Interleukin-17 in the development of arterial hypertension. |
2010 | Scientific Funding by the Foundation Mainzer Herz: The role of Interleukin-17A in the development of hypertension in context of the general contribution of the immune system to the development of endothelial dysfunction. |
Publikationen
- Kossmann S, Lagrange J, Jackel S, Jurk K, Ehlken M, Schonfelder T, Weihert Y, Knorr M, Brandt M, Xia N, Li H, Daiber A, Oelze M, Reinhardt C, Lackner K, Gruber A, Monia B, Karbach SH, Walter U, Ruggeri ZM, Renne T, Ruf W, Munzel T, Wenzel P. Platelet-localized fxi promotes a vascular coagulation-inflammatory circuit in arterial hypertension. Science translational medicine. 2017;9
- Uluckan O, Jimenez M, Karbach S, Jeschke A, Grana O, Keller J, Busse B, Croxford AL, Finzel S, Koenders M, van den Berg W, Schinke T, Amling M, Waisman A, Schett G, Wagner EF. Chronic skin inflammation leads to bone loss by il-17-mediated inhibition of wnt signaling in osteoblasts. Science translational medicine. 2016;8:330ra337
- Klebow S, Hahn M, Nikoalev A, Wunderlich FT, Hovelmeyer N, Karbach* SH, Waisman* A. Il-6 signaling in myelomonocytic cells is not crucial for the development of imq-induced psoriasis. PloS one. 2016;11:e0151913. *contributed equally
- Karbach SH, Schonfelder T, Brandao I, Wilms E, Hormann N, Jackel S, Schuler R, Finger S, Knorr M, Lagrange J, Brandt M, Waisman A, Kossmann S, Schafer K, Munzel T, Reinhardt C, Wenzel P. Gut microbiota promote angiotensin ii-induced arterial hypertension and vascular dysfunction. Journal of the American Heart Association. 2016;5
- Wenzel P, Rossmann H, Muller C, Kossmann S, Oelze M, Schulz A, Arnold N, Simsek C, Lagrange J, Klemz R, Schonfelder T, Brandt M, Karbach SH, Knorr M, Finger S, Neukirch C, Hauser F, Beutel ME, Kroller-Schon S, Schulz E, Schnabel RB, Lackner K, Wild PS, Zeller T, Daiber A, Blankenberg S, Munzel T. Heme oxygenase-1 suppresses a pro-inflammatory phenotype in monocytes and determines endothelial function and arterial hypertension in mice and humans. Eur Heart J. 2015;36:3437-3446
- Kossmann S, Hu H, Steven S, Schonfelder T, Fraccarollo D, Mikhed Y, Brahler M, Knorr M, Brandt M, Karbach SH, Becker C, Oelze M, Bauersachs J, Widder J, Munzel T, Daiber A, Wenzel P. Inflammatory monocytes determine endothelial nitric-oxide synthase uncoupling and nitro-oxidative stress induced by angiotensin ii. The Journal of biological chemistry. 2014;289:27540-27550
- Karbach S, Wenzel P, Waisman A, Munzel T, Daiber A. Enos uncoupling in cardiovascular diseases--the role of oxidative stress and inflammation. Current pharmaceutical design. 2014;20:3579-3594
- Karbach S, Croxford AL, Oelze M, Schuler R, Minwegen D, Wegner J, Koukes L, Yogev N, Nikolaev A, Reissig S, Ullmann A, Knorr M, Waldner M, Neurath MF, Li H, Wu Z, Brochhausen C, Scheller J, Rose-John S, Piotrowski C, Bechmann I, Radsak M, Wild P, Daiber A, von Stebut E, Wenzel P, Waisman A, Munzel T. Interleukin 17 drives vascular inflammation, endothelial dysfunction, and arterial hypertension in psoriasis-like skin disease. Arterioscler Thromb Vasc Biol. 2014;34:2658-2668
- Croxford* AL, Karbach* S, Kurschus FC, Wortge S, Nikolaev A, Yogev N, Klebow S, Schuler R, Reissig S, Piotrowski C, Brylla E, Bechmann I, Scheller J, Rose-John S, Wunderlich FT, Munzel T, von Stebut E, Waisman A. Il-6 regulates neutrophil microabscess formation in il-17a-driven psoriasiform lesions. J Invest Dermatol. 2014;134:728-735. *contributed equally
- Simon* A, Karbach* S, Habermeier A, Closs EI. Decoding the substrate supply to human neuronal nitric oxide synthase. PloS one. 2013;8:e67707. *contributed equally
- Kossmann S, Schwenk M, Hausding M, Karbach SH, Schmidgen MI, Brandt M, Knorr M, Hu H, Kroller-Schon S, Schonfelder T, Grabbe S, Oelze M, Daiber A, Munze T, Becker C, Wenzel P. Angiotensin ii-induced vascular dysfunction depends on interferon-gamma-driven immune cell recruitment and mutual activation of monocytes and nk-cells. Arterioscler Thromb Vasc Biol. 2013
- El Malki* K, Karbach* SH, Huppert* J, Zayoud M, Reissig S, Schuler R, Nikolaev A, Karram K, Munzel T, Kuhlmann CR, Luhmann HJ, von Stebut E, Wortge S, Kurschus FC, Waisman A. An alternative pathway of imiquimod-induced psoriasis-like skin inflammation in the absence of interleukin-17 receptor a signaling. J Invest Dermatol. 2013;133:441-451. *contributed equally
- Kroller-Schon S, Knorr M, Hausding M, Oelze M, Schuff A, Schell R, Sudowe S, Scholz A, Daub S, Karbach S, Kossmann S, Gori T, Wenzel P, Schulz E, Grabbe S, Klein T, Munzel T, Daiber A. Glucose-independent improvement of vascular dysfunction in experimental sepsis by dipeptidyl-peptidase 4 inhibition. Cardiovasc Res. 2012;96:140-149
- Karbach S, Jansen T, Horke S, Heeren T, Scholz A, Coldewey M, Karpi A, Hausding M, Kroller-Schon S, Oelze M, Munzel T, Daiber A. Hyperglycemia and oxidative stress in cultured endothelial cells--a comparison of primary endothelial cells with an immortalized endothelial cell line. J Diabetes Complications. 2012;26:155-162
- Wenzel P, Knorr M, Kossmann S, Stratmann J, Hausding M, Schuhmacher S, Karbach SH, Schwenk M, Yogev N, Schulz E, Oelze M, Grabbe S, Jonuleit H, Becker C, Daiber A, Waisman A, Munzel T. Lysozyme m-positive monocytes mediate angiotensin ii-induced arterial hypertension and vascular dysfunction. Circulation. 2011;124:1370-1381
- Karbach S, Simon A, Slenzka A, Jaenecke I, Habermeier A, Martine U, Forstermann U, Closs EI. Relative contribution of different l-arginine sources to the substrate supply of endothelial nitric oxide synthase. J Mol Cell Cardiol. 2011;51:855-861
- Schuhmacher S, Wenzel P, Schulz E, Oelze M, Mang C, Kamuf J, Gori T, Jansen T, Knorr M, Karbach S, Hortmann M, Mathner F, Bhatnagar A, Forstermann U, Li H, Munzel T, Daiber A. Pentaerythritol tetranitrate improves angiotensin ii-induced vascular dysfunction via induction of heme oxygenase-1. Hypertension. 2010;55:897-904
- Jansen T, Hortmann M, Oelze M, Opitz B, Steven S, Schell R, Knorr M, Karbach S, Schuhmacher S, Wenzel P, Munzel T, Daiber A. Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1-evidence for direct and indirect antioxidant actions of bilirubin. J Mol Cell Cardiol. 2010;49:186-195