Centrum für Thrombose und Hämostase (CTH)

Publikationen

2019 - 2018 - 2017 - 2016 - 2015 - 2014 - 2013 - 2012 - 2011

Originalartikel 2019

Jäger M, Hubert A, Gogiraju R, Bochenek ML, Münzel T, Schäfer K. Inducible Knockdown of Endothelial Protein Tyrosine Phosphatase-1B Promotes Neointima Formation in Obese Mice by Enhancing Endothelial Senescence. Antioxid Redox Signal 2019;30(7):927-944.
Keller K, Hobohm L, Münzel T, Ostad MA. Syncope in the German Nationwide inpatient sample - Syncope in atrial fibrillation/flutter is related to pulmonary embolism and is accompanied by higher in-hospital mortality. Eur J Intern Med 2019;62:29-36.
Burghardt J, Klein E, Brähler E, Ernst M, Schneider A, Eckerle S, Neu MA, Wingerter A, Henninger N, Panova‐Noeva M, Prochaska J, Wild P, Beutel M, Faber J. Prevalence of mental distress among adult survivors of childhood cancer in Germany—Compared to the general population. Cancer Medicine 2019;8(4):1865-1874.
Hansen M, Peltier J, Killy B, Amin B, Bodendorfer B, Hartlova A, Uebel S, Bosmann M, Hofmann J, Buttner C, Ekici AB, Kuttke M, Franzyk H, Foged C, Beer-Hammer S, Schabbauer G, Trost M, Lang R. Macrophage Phosphoproteome Analysis Reveals MINCLE-dependent and -independent Mycobacterial Cord Factor Signaling. Mol Cell Proteomics 2019;18(4):669-685.
Rothmeier AS, Versteeg HH, Ruf W. Factor VIIa-induced interaction with integrin controls the release of tissue factor on extracellular vesicles from endothelial cells. J Thromb Haemost 2019;17(4):627-634.
Tziakas DN, Chalikias G, Pavlaki M, Kareli D, Gogiraju R, Hubert A, Bohm E, Stamoulis P, Drosos I, Kikas P, Mikroulis D, Giatromanolaki A, Georgiadis GS, Konstantinou F, Argyriou C, Münzel T, Konstantinides SV, Schäfer K. Lysed Erythrocyte Membranes Promote Vascular Calcification. Circulation 2019;139(17):2032-2048.
von Bardeleben RS, Hobohm L, Kreidel F, Ostad MA, Schulz E, Konstantinides S, Lankeit M, Feldman T, Münzel T, Keller K. Incidence and in-hospital safety outcomes of patients undergoing percutaneous mitral valve edge-to-edge repair using MitraClip: five-year German national patient sample including 13,575 implants. EuroIntervention 2019;14(17):1725-1732.
Barco S, Granziera S, Coppens M, Douxfils J, Nijkeuter M, Riva N, Vanassche T, Zhang G, Lin M, Kamphuisen PW, Cohen AT, Beyer-Westendorf J. Determinants of the Quality of Warfarin Control after Venous Thromboembolism and Validation of the SAMe-TT2-R2 Score: An Analysis of Hokusai-VTE. Thromb Haemost 2019;119(4):675-684.
Keller K, Geyer M, Münzel T, Ostad MA, Gori T. Impact of atrial fibrillation on in-hospital mortality of ischemic stroke patients and identification of promoting factors of atrial thrombi - Results from the German nationwide inpatient sample and a single-center retrospective cohort. Medicine (Baltimore) 2019;98(4):e14086.
Keller K, Hobohm L, Münzel T, Ostad MA. Impact of symptomatic atherosclerosis in patients with pulmonary embolism. Int J Cardiol 2019;278:225-231.
Keller K, Hobohm L, Münzel T, Ostad MA, Espinola-Klein C. Impact of chronic obstructive pulmonary disease on the outcomes of patients with peripheral artery disease. Respir Med 2019;147:1-6.
Beutel ME, Wiltink J, Ghaemi Kerahrodi J, Tibubos AN, Brähler E, Schulz A, Wild P, Münzel T, Lackner K, König J, Pfeiffer N, Michal M, Henning M. Somatic symptom load in men and women from middle to high age in the Gutenberg Health Study - association with psychosocial and somatic factors. Sci Rep 2019;9(1):4610.
Dörr M, Hamburg NM, Müller C, Smith NL, Gustafsson S, Lehtimäki T, Teumer A, Zeller T, Li X, Lind L, Raitakari OT, Völker U, Blankenberg S, McKnight B, Morris AP, Kähönen M, Lemaitre RN, Wild PS, Nauck M, Völzke H, Münzel T, Mitchell GF, Psaty BM, Lindgren CM, Larson MG, Felix SB, Ingelsson E, Lyytikäinen LP, Herrington D, Benjamin EJ, Schnabel RB. Common Genetic Variation in Relation to Brachial Vascular Dimensions and Flow-Mediated Vasodilation. Circ Genom Precis Med 2019;12(2):e002409.
Gawish R, Bulat T, Biaggio M, Lassnig C, Bago-Horvath Z, Macho-Maschler S, Poelzl A, Simonovic N, Prchal-Murphy M, Rom R, Amenitsch L, Ferrarese L, Kornhoff J, Lederer T, Svinka J, Eferl R, Bosmann M, Kalinke U, Stoiber D, Sexl V, Krmpotic A, Jonjic S, Müller M, Strobl B. Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1. Cell Rep 2019;26(9):2394-2406 e2395.
Sharma A, Steven S, Bosmann M. The pituitary gland prevents shock-associated death by controlling multiple inflammatory mediators. Biochem Biophys Res Commun 2019;509(1):188-193.
Hewel C, Kaiser J, Wierczeiko A, Linke J, Reinhardt C, Endres K, Gerber S. Common miRNA Patterns of Alzheimer's Disease and Parkinson's Disease and Their Putative Impact on Commensal Gut Microbiota. Front Neurosci 2019;13:113.
Caminero A, McCarville JL, Galipeau HJ, Deraison C, Bernier SP, Constante M, Rolland C, Meisel M, Murray JA, Yu XB, Alaedini A, Coombes BK, Bercik P, Southward CM, Ruf W, Jabri B, Chirdo FG, Casqueiro J, Surette MG, Vergnolle N, Verdu EF. Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2. Nat Commun 2019;10(1):1198.
Sutherland MR, Simon AY, Shanina I, Horwitz MS, Ruf W, Pryzdial ELG. Virus envelope tissue factor promotes infection in mice. J Thromb Haemost 2019;17(3):482-491.
Chalikias G, Serif L, Kikas P, Thomaidis A, Stakos D, Makrygiannis D, Chatzikyriakou S, Papoulidis N, Voudris V, Lantzouraki A, Müller M, Arampatzis S, Konstantinides S, Tziakas D. Long-term impact of acute kidney injury on prognosis in patients with acute myocardial infarction. Int J Cardiol 2019;283:48-54.
Gogiraju R, Hubert A, Fahrer J, Straub BK, Brandt M, Wenzel P, Münzel T, Konstantinides S, Hasenfuss G, Schäfer K. Endothelial Leptin Receptor Deletion Promotes Cardiac Autophagy and Angiogenesis Following Pressure Overload by Suppressing Akt/mTOR Signaling. Circ Heart Fail 2019;12(1):e005622.
Kostrubiec M, Plywaczewska M, Jimenez D, Lankeit M, Ciurzynski M, Konstantinides S, Pruszczyk P. The Prognostic Value of Renal Function in Acute Pulmonary Embolism-A Multi-Centre Cohort Study. Thromb Haemost 2019;119(1):140-148.
Kiouptsi K, Finger S, Garlapati VS, Knorr M, Brandt M, Walter U, Wenzel P, Reinhardt C. Hypoxia evokes increased PDI and PDIA6 expression in the infarcted myocardium of ex-germ-free and conventionally raised mice. Biol Open 2019;8(1).
Barco S, Mahmoudpour SH, Planquette B, Sanchez O, Konstantinides SV, Meyer G. Prognostic value of right ventricular dysfunction or elevated cardiac biomarkers in patients with low-risk pulmonary embolism: a systematic review and meta-analysis. Eur Heart J 2019;40(11):902-910.
Kröller-Schön S, Jansen T, Tran TLP, Kvandova M, Kalinovic S, Oelze M, Keaney JF, Jr., Foretz M, Viollet B, Daiber A, Kossmann S, Lagrange J, Frenis K, Wenzel P, Münzel T, Schulz E. Endothelial alpha1AMPK modulates angiotensin II-mediated vascular inflammation and dysfunction. Basic Res Cardiol 2019;114(2):8.
Schüler R, Brand A, Klebow S, Wild J, Veras FP, Ullmann E, Roohani S, Kolbinger F, Kossmann S, Wohn C, Daiber A, Münzel T, Wenzel P, Waisman A, Clausen BE, Karbach S. Antagonization of IL-17A Attenuates Skin Inflammation and Vascular Dysfunction in Mouse Models of Psoriasis. J Invest Dermatol 2019;139(3):638-647.
Barco S, Klok FA, Mahe I, Marchena PJ, Ballaz A, Rubio CM, Adarraga MD, Mastroiacovo D, Konstantinides SV, Monreal M, Investigators R. Impact of sex, age, and risk factors for venous thromboembolism on the initial presentation of first isolated symptomatic acute deep vein thrombosis. Thromb Res 2019;173:166-171.
Klok FA, Pruefer D, Rolf A, Konstantinides SV. Magnetic resonance direct thrombus imaging for pre-operative assessment of acute thrombosis in chronic thromboembolic pulmonary hypertension. Eur Heart J 2019;40(11):944.
Sacco C, Zane F, Granziera S, Holm K, Creemers-Schild D, Hotz MA, Turpini E, Valentini A, Righini C, Karkos PD, Verhamme P, Di Nisio M, Konstantinides S, Pecci A, Barco S, Lemierre Study G. Lemierre Syndrome: Clinical Update and Protocol for a Systematic Review and Individual Patient Data Meta-analysis. Hamostaseologie 2019;39(1):76-86.
Prochaska JH, Luther N, Brähler M, Schulz A, Hermanns MI, Lackner KJ, Espinola-Klein C, Münzel T, Wild PS, Becker C. Acute deep vein thrombosis suppresses peripheral T cell effector function. Br J Haematol 2019;184(5):847-850.
Hain T, Melchior F, Kamenjarin N, Muth S, Weslati H, Clausen BE, Mahnke K, Silva-Vilches C, Schutze K, Sohl J, Radsak MP, Bundgen G, Bopp T, Danckwardt S, Schild H, Probst HC. Dermal CD207-Negative Migratory Dendritic Cells Are Fully Competent to Prime Protective, Skin Homing Cytotoxic T-Lymphocyte Responses. J Invest Dermatol 2019;139(2):422-429.
Bibli SI, Papapetropoulos A, Iliodromitis EK, Daiber A, Randriamboavonjy V, Steven S, Brouckaert P, Chatzianastasiou A, Kypreos KE, Hausenloy DJ, Fleming I, Andreadou I. Nitroglycerine limits infarct size through S-nitrosation of cyclophilin D: a novel mechanism for an old drug. Cardiovasc Res 2019;115(3):625-636.
Börschel CS, Rübsamen N, Ojeda FM, Wild PS, Hoffmann BA, Prochaska JH, Gori T, Lackner KJ, Blankenberg S, Zeller T, Münzel T, Schnabel RB. Noninvasive peripheral vascular function and atrial fibrillation in the general population. J Hypertens 2019;37(5):928-934.
Panova-Noeva M, Neu MA, Eckerle S, Spix C, Schneider A, Schmidtmann I, Spronk HM, Pfeiffer N, Beutel M, Lackner KJ, Münzel T, Ten Cate H, Merzenich H, Faber J, Wild PS. Cardiovascular risk factors are important determinants of platelet-dependent thrombin generation in adult survivors of childhood cancer. Clin Res Cardiol 2019;108(4):438-447.
Eggebrecht L, Nagler M, Göbel S, Lamparter H, Keller K, Wagner B, Panova-Noeva M, Ten Cate V, Bickel C, Lauterbach M, Espinola-Klein C, Hardt R, Münzel T, Prochaska JH, Wild PS. Relevance of Polypharmacy for Clinical Outcome in Patients Receiving Vitamin K Antagonists. J Am Geriatr Soc 2019;67(3):463-470.
Keller K. Life Expectancy of Olympic Wrestling Champions in Comparison to the General Population. J Community Health 2019;44(1):61-67.

Reviews 2019

Formes H, Reinhardt C. The gut microbiota - a modulator of endothelial cell function and a contributing environmental factor to arterial thrombosis. Expert Rev Hematol 2019:1-9.
Keller K. Sarcopenia. Wien Med Wochenschr 2019;169(7-8):157-172.
Gogiraju R, Bochenek ML, Schäfer K. Angiogenic Endothelial Cell Signaling in Cardiac Hypertrophy and Heart Failure. Front Cardiovasc Med 2019;6:20.
Petris AO, Konstantinides S, Tint D, Cimpoesu D, Pop C. Therapeutic Advances in Emergency Cardiology: Acute Pulmonary Embolism. Am J Ther 2019;26(2):e248-e256.
Aissaoui N, Konstantinides S, Meyer G. What's new in severe pulmonary embolism? Intensive Care Med 2019;45(1):75-77.

Editorials und Fachbeiträge 2019

Keller K, Hobohm L. Identification of normotensive patients with pulmonary embolism who may benefit from thrombolysis. Int J Cardiol 2019;281:125-126.
Prochaska JH, Tröbs SO, Wild PS. PCSK9: A link between air pollution and cardiovascular disease? Eur J Prev Cardiol 2019;26(6):576-577.
Pontarollo G, Melzow F, Reinhardt C. Comment on "Endothelial Protein C Receptor (EPCR), Protease Activated Receptor-1 (PAR-1) and Their Interplay in Cancer Growth and Metastatic Dissemination" Cancers 2019, 11, 51. Cancers (Basel) 2019;11(3).
Becker C, Reinhardt C. Unexpected role of natural killer cell-derived interferon-gamma as a driver of NETosis and DVT. J Thromb Haemost 2019;17(2):400-402.

Originalartikel 2018

Keller K, Beule J, Balzer JO, Dippold W. D-Dimer and thrombus burden in acute pulmonary embolism. Am J Emerg Med 2018;36(9):1613-1618.
Steven S, Oelze M, Hausding M, Roohani S, Kashani F, Kröller-Schön S, Helmstädter J, Jansen T, Baum C, Iglarz M, Schulz E, Münzel T, Daiber A. The Endothelin Receptor Antagonist Macitentan Improves Isosorbide-5-Mononitrate (ISMN) and Isosorbide Dinitrate (ISDN) Induced Endothelial Dysfunction, Oxidative Stress, and Vascular Inflammation. Oxid Med Cell Longev 2018;2018:7845629.
Barco S, Ende-Verhaar YM, Becattini C, Jimenez D, Lankeit M, Huisman MV, Konstantinides SV, Klok FA. Differential impact of syncope on the prognosis of patients with acute pulmonary embolism: a systematic review and meta-analysis. Eur Heart J 2018.
Wilkens H, Konstantinides S, Lang IM, Bunck AC, Gerges M, Gerhardt F, Grgic A, Grohe C, Guth S, Held M, Hinrichs JB, Hoeper MM, Klepetko W, Kramm T, Kruger U, Lankeit M, Meyer BC, Olsson KM, Schafers HJ, Schmidt M, Seyfarth HJ, Ulrich S, Wiedenroth CB, Mayer E. Chronic thromboembolic pulmonary hypertension (CTEPH): Updated Recommendations from the Cologne Consensus Conference 2018. Int J Cardiol 2018;272S:69-78.
Ogorodnikov A, Levin M, Tattikota S, Tokalov S, Hoque M, Scherzinger D, Marini F, Poetsch A, Binder H, Macher-Göppinger S, Probst HC, Tian B, Schaefer M, Lackner KJ, Westermann F, Danckwardt S. Transcriptome 3'end organization by PCF11 links alternative polyadenylation to formation and neuronal differentiation of neuroblastoma. Nat Commun 2018;9(1):5331.
Dentali F, Barco S, Pegoraro S, Di Minno MND, Mastroiacovo D, Pomero F, Lodigiani C, Bagna F, Sartori M, Barillari G, Mumoli N, Napolitano M, Passamonti SM, Benedetti R, Ageno W, Di Nisio M. Residual vein obstruction in patients diagnosed with acute isolated distal deep vein thrombosis associated with active cancer. J Thromb Thrombolysis 2018;46(3):404-408.
Scheres LJJ, Lijfering WM, Middeldorp S, Cheung YW, Barco S, Cannegieter SC, Coppens M. Measurement of coagulation factors during rivaroxaban and apixaban treatment: Results from two crossover trials. Res Pract Thromb Haemost 2018;2(4):689-695.
Keller K, Beule J, Balzer JO, Dippold W. Evaluation of Risk Stratification Markers and Models in Acute Pulmonary Embolism: Rationale and Design of the MARS-PE (Mainz Retrospective Study of Pulmonary Embolism) Study Programme. Acta Medica (Hradec Kralove) 2018;61(3):93-97.
Keller K, Hobohm L, Engelhardt M. Impact of Atrial Fibrillation on Postoperative Adverse Outcomes of Surgical Patients With Knee Endoprosthetic Surgery. J Arthroplasty 2018;33(11):3567-3573.
Keller K, Hobohm L, Münzel T, Ostad MA, Espinola-Klein C. Syncope in haemodynamically stable and unstable patients with acute pulmonary embolism - Results of the German nationwide inpatient sample. Sci Rep 2018;8(1):15789.
Klok FA, Barco S, Turpie AGG, Haas S, Kreutz R, Mantovani LG, Gebel M, Herpers M, Bugge JP, Kostantinides SV, Ageno W. Predictive value of venous thromboembolism (VTE)-BLEED to predict major bleeding and other adverse events in a practice-based cohort of patients with VTE: results of the XALIA study. Br J Haematol 2018;183(3):457-465.
Ligthart S, Vaez A, Vosa U, Stathopoulou MG, de Vries PS, Prins BP, Van der Most PJ, Tanaka T, Naderi E, Rose LM […] Wild PS […] Gross M, Bis JC, Franke L, Franco OH, Benjamin EJ, Chasman DI, Dupuis J, Snieder H, Dehghan A, Alizadeh BZ. Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. Am J Hum Genet 2018;103(5):691-706.
Eggebrecht L, Prochaska JH, Schulz A, Arnold N, Jünger C, Gobel S, Laubert-Reh D, Binder H, Beutel ME, Pfeiffer N, Blankenberg S, Lackner KJ, Spronk HM, Ten Cate H, Münzel T, Wild PS. Intake of Vitamin K Antagonists and Worsening of Cardiac and Vascular Disease: Results From the Population-Based Gutenberg Health Study. J Am Heart Assoc 2018;7(17):e008650.
Göbel S*, Prochaska JH*, Eggebrecht L, Schmitz R, Jünger C, Lamparter H, Nagler M, Keller K, Coldewey M, Tröbs SO, Diestelmeier S, Schwuchow-Thonke S, Bickel C, Lauterbach M, Lackner KJ, Cate HT, Münzel T, Hardt R, Wild PS. Management of Oral Anti-Coagulation in Patients with Heart Failure-Insights from the ThrombEVAL Study. Thromb Haemost 2018;118(11):1930-1939. * equal contribution
Haase T, Müller C, Krause J, Rothemeier C, Stenzig J, Kunze S, Waldenberger M, Münzel T, Pfeiffer N, Wild PS, Michal M, Marini F, Karakas M, Lackner KJ, Blankenberg S, Zeller T. Novel DNA Methylation Sites Influence GPR15 Expression in Relation to Smoking. Biomolecules 2018;8(3).
Niekamp C, Atzler D, Ojeda FM, Sinning CR, Lackner KJ, Boger RH, Münzel T, Beutel ME, Schmidtmann I, Pfeiffer N, Leuschner A, Blankenberg S, Wild PS, Zeller T, Schwedhelm E, Schnabel RB. Cross-Sectional Associations between Homoarginine, Intermediate Phenotypes, and Atrial Fibrillation in the Community-The Gutenberg Health Study. Biomolecules 2018;8(3).
Tibubos AN, Beutel ME, Schulz A, Klein EM, Brahler E, Michal M, Münzel T, Wild PS, Lackner K, Konig J, Pfeiffer N, Wiltink J. Is assessment of depression equivalent for migrants of different cultural backgrounds? Results from the German population-based Gutenberg Health Study (GHS). Depress Anxiety 2018;35(12):1178-1189.
van Setten J, Brody JA, Jamshidi Y, Swenson BR, Butler AM, Campbell H, Del Greco FM, Evans DS, Gibson Q, Gudbjartsson DF […] Wild PS […] Stefansson K, Stricker BH, van der Harst P, van Duijn CM, Wilson JF, Gharib SA, de Bakker PIW, Isaacs A, Arking DE, Sotoodehnia N. PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity. Nat Commun 2018;9(1):2904.
Höhn R, Nickels S, Schuster AK, Wild PS, Münzel T, Lackner KJ, Schmidtmann I, Beutel M, Pfeiffer N. Prevalence of glaucoma in Germany: results from the Gutenberg Health Study. Graefes Arch Clin Exp Ophthalmol 2018;256(9):1695-1702.
Magnussen C, Ojeda FM, Wild PS, Sorensen N, Rostock T, Hoffmann BA, Prochaska J, Lackner KJ, Beutel ME, Blettner M, Pfeiffer N, Rzayeva N, Sinning CR, Blankenberg S, Münzel T, Zeller T, Schnabel RB. Atrial Fibrillation Manifestations Risk Factors and Sex Differences in a Population-Based Cohort (From the Gutenberg Health Study). Am J Cardiol 2018;122(1):76-82.
Prochaska JH, Göbel S, Nagler M, Knöpfler T, Eggebrecht L, Lamparter H, Panova-Noeva M, Keller K, Coldewey M, Bickel C, Lauterbach M, Hardt R, Espinola-Klein C, Ten Cate H, Rostock T, Münzel T, Wild PS. Sustained atrial fibrillation increases the risk of anticoagulation-related bleeding in heart failure. Clin Res Cardiol 2018.
Nourse J, Braun J, Lackner K, Hüttelmaier S, Danckwardt S. Large-scale identification of functional microRNA targeting reveals cooperative regulation of the hemostatic system. J Thromb Haemost 2018;16(11):2233-2245.
Colucci G, Helsing K, Biasiutti FD, Raio L, Schmid P, Tsakiris DA, Eberle B, Surbek D, Lämmle B, Alberio L. Standardized Management Protocol in Severe Postpartum Hemorrhage: A Single-Center Study. Clin Appl Thromb Hemost 2018;24(6):884-893.
Klatt C, Krüger I, Zey S, Krott KJ, Spelleken M, Gowert NS, Oberhuber A, Pfaff L, Luckstadt W, Jurk K, Schaller M, Al-Hasani H, Schrader J, Massberg S, Stark K, Schelzig H, Kelm M, Elvers M. Platelet-RBC interaction mediated by FasL/FasR induces procoagulant activity important for thrombosis. J Clin Invest 2018;128(9):3906-3925.
Urbahn MA, Kaup SC, Reusswig F, Kruger I, Spelleken M, Jurk K, Klier M, Lang PA, Elvers M. Phospholipase D1 regulation of TNF-alpha protects against responses to LPS. Sci Rep 2018;8(1):10006.
Falter T, Herold S, Weyer-Elberich V, Scheiner C, Schmitt V, von Auer C, Messmer X, Wild P, Lackner KJ, Lämmle B, Scharrer I. Relapse Rate in Survivors of Acute Autoimmune Thrombotic Thrombocytopenic Purpura Treated with or without Rituximab. Thromb Haemost 2018;118(10):1743-1751.
Brandt M, Giokoglu E, Garlapati V, Bochenek ML, Molitor M, Hobohm L, Schönfelder T, Münzel T, Kossmann S, Karbach SH, Schäfer K, Wenzel P. Pulmonary Arterial Hypertension and Endothelial Dysfunction Is Linked to NADPH Oxidase-Derived Superoxide Formation in Venous Thrombosis and Pulmonary Embolism in Mice. Oxid Med Cell Longev 2018;2018:1860513.
Jansen T, Kröller-Schön S, Schönfelder T, Foretz M, Viollet B, Daiber A, Oelze M, Brandt M, Steven S, Kvandova M, Kalinovic S, Lagrange J, Keaney JF, Jr., Münzel T, Wenzel P, Schulz E. alpha1AMPK deletion in myelomonocytic cells induces a pro-inflammatory phenotype and enhances angiotensin II-induced vascular dysfunction. Cardiovasc Res 2018;114(14):1883-1893.
Kröller-Schön S, Daiber A, Steven S, Oelze M, Frenis K, Kalinovic S, Heimann A, Schmidt FP, Pinto A, Kvandova M, Vujacic-Mirski K, Filippou K, Dudek M, Bosmann M, Klein M, Bopp T, Hahad O, Wild PS, Frauenknecht K, Methner A, Schmidt ER, Rapp S, Mollnau H, Münzel T. Crucial role for Nox2 and sleep deprivation in aircraft noise-induced vascular and cerebral oxidative stress, inflammation, and gene regulation. Eur Heart J 2018;39(38):3528-3539.
Sotiriou E, Heiner S, Jansen T, Brandt M, Schmidt KH, Kreitner KF, Emrich T, Schultheiss HP, Schulz E, Münzel T, Wenzel P. Therapeutic implications of a combined diagnostic workup including endomyocardial biopsy in an all-comer population of patients with heart failure: a retrospective analysis. ESC Heart Fail 2018;5(4):630-641.
Lindskog Jonsson A, Caesar R, Akrami R, Reinhardt C, Fak Hallenius F, Boren J, Bäckhed F. Impact of Gut Microbiota and Diet on the Development of Atherosclerosis in Apoe(-/-) Mice. Arterioscler Thromb Vasc Biol 2018;38(10):2318-2326.
Klok FA, Barco S, Konstantinides SV, Dartevelle P, Fadel E, Jenkins D, Kim NH, Madani M, Matsubara H, Mayer E, Pepke-Zaba J, Delcroix M, Lang IM. Determinants of diagnostic delay in chronic thromboembolic pulmonary hypertension: results from the European CTEPH Registry. Eur Respir J 2018;52(6).
Kaymaz C, Akbal OY, Hakgor A, Tokgoz HC, Karagoz A, Tanboga IH, Tanyeri S, Keskin B, Turkday S, Demir D, Dogan C, Bayram Z, Acar RD, Guvendi B, Ozdemir N, Tapson VF, Konstantinides S. A five-year, single-centre experience on ultrasound-assisted, catheter-directed thrombolysis in patients with pulmonary embolism at high risk and intermediate to high risk. EuroIntervention 2018;14(10):1136-1143.
Spyropoulos AC, Ageno W, Albers GW, Elliott CG, Halperin JL, Hiatt WR, Maynard GA, Steg PG, Weitz JI, Suh E, Spiro TE, Barnathan ES, Raskob GE, Investigators M. Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness. N Engl J Med 2018;379(12):1118-1127.
Trinchero A, Scheres LJJ, Prochaska JH, Ambaglio C, Wild PS, Middeldorp S, Konstantinides SV, Barco S. Sex-specific differences in the distal versus proximal presenting location of acute deep vein thrombosis. Thromb Res 2018;172:74-79.
Dellas C, Lobo JL, Rivas A, Ballaz A, Portillo AK, Nieto R, Del Rey JM, Zamorano JL, Lankeit M*, Jimenez D*. Risk stratification of acute pulmonary embolism based on clinical parameters, H-FABP and multidetector CT. Int J Cardiol 2018;265:223-228. *equal contribution.
Khandagale A, Kittner JM, Mann A, Ascher S, Kollar B, Reinhardt C. Coagulation factor 9-deficient mice are protected against dextran sulfate sodium-induced colitis. Biol Open 2018;7(7).
Westmeier D, Solouk-Saran D, Vallet C, Siemer S, Docter D, Götz H, Männ L, Hasenberg A, Hahlbrock A, Erler K, Reinhardt C, Schilling O, Becker S, Gunzer M, Hasenberg M, Knauer SK, Stauber RH. Nanoparticle decoration impacts airborne fungal pathobiology. Proc Natl Acad Sci U S A 2018;115(27):7087-7092.
Dellas C, Lobo JL, Rivas A, Ballaz A, Portillo AK, Nieto R, Del Rey JM, Zamorano JL, Lankeit M, Jimenez D. Risk stratification of acute pulmonary embolism based on clinical parameters, H-FABP and multidetector CT. Int J Cardiol 2018;265:223-228.
Unterrainer JM, Domschke K, Rahm B, Wiltink J, Schulz A, Pfeiffer N, Lackner KJ, Münzel T, Wild PS, Beutel M. Subclinical levels of anxiety but not depression are associated with planning performance in a large population-based sample. Psychol Med 2018;48(1):168-174.
Rezapour J, Nickels S, Schuster AK, Michal M, Münzel T, Wild PS, Schmidtmann I, Lackner K, Schulz A, Pfeiffer N, Beutel ME. Prevalence of depression and anxiety among participants with glaucoma in a population-based cohort study: The Gutenberg Health Study. BMC Ophthalmol 2018;18(1):157.
Müller-Calleja N, Ritter S, Hollerbach A, Falter T, Lackner KJ, Ruf W. Complement C5 but not C3 is expendable for tissue factor activation by cofactor-independent antiphospholipid antibodies. Blood Adv 2018;2(9):979-986.
Rue-Albrecht K, Marini F, Soneson C, Lun ATL. iSEE: Interactive SummarizedExperiment Explorer. F1000Res 2018;7:741.
Lamparter J, Schmidtmann I, Schuster AK, Siouli A, Wasielica-Poslednik J, Mirshahi A, Höhn R, Unterrainer J, Wild PS, Binder H, Lackner K, Beutel ME, Münzel T, Pfeiffer N, Hoffmann EM. Association of ocular, cardiovascular, morphometric and lifestyle parameters with retinal nerve fibre layer thickness. PLoS One 2018;13(5):e0197682.
Wiltink J, Michal M, Jünger C, Münzel T, Wild PS, Lackner KJ, Blettner M, Pfeiffer N, Brähler E, Beutel ME. Associations between degree and sub-dimensions of depression and metabolic syndrome (MetS) in the community: results from the Gutenberg Health Study (GHS). BMC Psychiatry 2018;18(1):114.
Parry BA, Chang AM, Schellong SM, House SL, Fermann GJ, Deadmon EK, Giordano NJ, Chang Y, Cohen J, Robak N, Singer AJ, Mulrow M, Reibling ET, Francis S, Griffin SM, Prochaska JH, Davis B, McNelis P, Delgado J, Kumpers P, Werner N, Gentile NT, Zeserson E, Wild PS, Limkakeng AT, Jr., Walters EL, LoVecchio F, Theodoro D, Hollander JE, Kabrhel C. International, multicenter evaluation of a new D-dimer assay for the exclusion of venous thromboembolism using standard and age-adjusted cut-offs. Thromb Res 2018;166:63-70.
Panova-Noeva M, Schulz A, Spronk HM, Beicht A, Laubert-Reh D, van Oerle R, Arnold N, Prochaska JH, Blettner M, Beutel M, Pfeiffer N, Münzel T, Lackner KJ, Ten Cate H, Wild PS. Clinical Determinants of Thrombin Generation Measured in Presence and Absence of Platelets-Results from the Gutenberg Health Study. Thromb Haemost 2018;118(5):873-882.
Yu Y, Boing AN, Hau CM, Hajji N, Ruf W, Sturk A, Nieuwland R. Tissue Factor Coagulant Activity is Regulated by the Plasma Membrane Microenvironment. Thromb Haemost 2018;118(6):990-1000.
Bochenek ML, Bauer T, Gogiraju R, Nadir Y, Mann A, Schönfelder T, Hunig L, Brenner B, Münzel T, Wenzel P, Konstantinides S, Schäfer K. The endothelial tumor suppressor p53 is essential for venous thrombus formation in aged mice. Blood Adv 2018;2(11):1300-1314.
Hellenkamp K, Pruszczyk P, Jimenez D, Wyzgal A, Barrios D, Ciurzynski M, Morillo R, Hobohm L, Keller K, Kurnicka K, Kostrubiec M, Wachter R, Hasenfuss G, Konstantinides S, Lankeit M. Prognostic impact of copeptin in pulmonary embolism: a multicentre validation study. Eur Respir J 2018;51(4).
Faber J, Wingerter A, Neu MA, Henninger N, Eckerle S, Münzel T, Lackner KJ, Beutel ME, Blettner M, Rathmann W, Peters A, Meisinger C, Linkohr B, Neuhauser H, Kaatsch P, Spix C, Schneider A, Merzenich H, Panova-Noeva M, Prochaska JH, Wild PS. Burden of cardiovascular risk factors and cardiovascular disease in childhood cancer survivors: data from the German CVSS-study. Eur Heart J 2018;39(17):1555-1562.
Herrmann WJ, Weikert C, Bergmann M, Boeing H, Katzke VA, Kaaks R, Tiller D, Greiser KH, Heier M, Meisinger C, Schmidt CO, Neuhauser H, Heidemann C, Jünger C, Wild PS, Schramm SH, Jöckel KH, Dörr M, Pischon T. [Assessing incident cardiovascular and metabolic diseases in epidemiological cohort studies in Germany]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2018;61(4):420-431.
Lauber S, Limacher A, Tritschler T, Stalder O, Mean M, Righini M, Aschwanden M, Beer JH, Frauchiger B, Osterwalder J, Kucher N, Lämmle B, Cornuz J, Angelillo-Scherrer A, Matter CM, Husmann M, Banyai M, Staub D, Mazzolai L, Hugli O, Rodondi N, Aujesky D. Predictors and Outcomes of Recurrent Venous Thromboembolism in Elderly Patients. Am J Med 2018;131(6):703 e707-703 e716.
Makhoul S, Walter E, Pagel O, Walter U, Sickmann A, Gambaryan S, Smolenski A, Zahedi RP, Jurk K. Effects of the NO/soluble guanylate cyclase/cGMP system on the functions of human platelets. Nitric Oxide 2018;76:71-80.
Ebert J, Wilgenbus P, Teiber JF, Jurk K, Schwierczek K, Döhrmann M, Xia N, Li H, Spiecker L, Ruf W, Horke S. Paraoxonase-2 regulates coagulation activation through endothelial tissue factor. Blood 2018;131(19):2161-2172.
Panova-Noeva M, Schulz A, Arnold N, Hermanns MI, Prochaska JH, Laubert-Reh D, Spronk HM, Blettner M, Beutel M, Pfeiffer N, Münzel T, Lackner KJ, Ten Cate H, Wild PS. Coagulation and inflammation in long-term cancer survivors: results from the adult population. J Thromb Haemost 2018;16(4):699-708.
Kurakula K, Koenis DS, Herzik MA, Jr., Liu Y, Craft JW, Jr., van Loenen PB, Vos M, Tran MK, Versteeg HH, Goumans MTH, Ruf W, de Vries CJM, Sen M. Structural and cellular mechanisms of peptidyl-prolyl isomerase Pin1-mediated enhancement of Tissue Factor gene expression, protein half-life, and pro-coagulant activity. Haematologica 2018;103(6):1073-1082.
Eggebrecht L*, Prochaska JH*, Schleuter L, Nagler M, Hardt R, Schinzel H, Münzel T, Wild PS. [Physicians' Opinion on Health Care in Oral Anticoagulation]. Dtsch Med Wochenschr 2018;143(9):e76-e84.
Siegismund CS, Escher F, Lassner D, Kühl U, Gross U, Fruhwald F, Wenzel P, Münzel T, Frey N, Linke RP, Schultheiss HP. Intramyocardial inflammation predicts adverse outcome in patients with cardiac AL amyloidosis. Eur J Heart Fail 2018;20(4):751-757.
Jimenez-Alcazar M, Limacher A, Panda R, Mean M, Bitterling J, Peine S, Renne T, Beer JH, Aujesky D, Lämmle B, Fuchs TA. Circulating extracellular DNA is an independent predictor of mortality in elderly patients with venous thromboembolism. PLoS One 2018;13(2):e0191150.
Rothmeier AS, Liu E, Chakrabarty S, Disse J, Mueller BM, Ostergaard H, Ruf W. Identification of the integrin-binding site on coagulation factor VIIa required for proangiogenic PAR2 signaling. Blood 2018;131(6):674-685.
Rodger M, Langlois N, Middeldorp S, Kahn S, Sandset PM, Brighton T, Huisman MV, Meyer G, Konstantinides S, Ageno W, Morange P, Garcia D, Kreuziger LB, Young L, Key N, Monreal M, Jimenez D. Initial strides for invent-VTE: Towards global collaboration to accelerate clinical research in venous thromboembolism. Thromb Res 2018;163:128-131.
Schönfelder T, Brandt M, Kossmann S, Knopp T, Münzel T, Walter U, Karbach SH, Wenzel P. Lack of T-bet reduces monocytic interleukin-12 formation and accelerates thrombus resolution in deep vein thrombosis. Sci Rep 2018;8(1):3013.
Lagrange J, Kossmann S, Kiouptsi K, Wenzel P. Visualizing Leukocyte Rolling and Adhesion in Angiotensin II-Infused Mice: Techniques and Pitfalls. J Vis Exp 2018(131).
Barco S, Vicaut E, Klok FA, Lankeit M, Meyer G, Konstantinides SV, Investigators P. Improved identification of thrombolysis candidates amongst intermediate-risk pulmonary embolism patients: implications for future trials. Eur Respir J 2018;51(1).
Oelze M, Welschof P, Knorr M, Tran LP, Ullmann E, Stamm P, Kröller-Schön S, Jansen T, Kopp M, Schulz E, Gori T, Burgin K, Scherhag A, Sartor D, Münzel T, Daiber A. Basic in vitro Characterization of the Vasodilatory Potential of 2-Aminoethyl Nitrate Fixed-Dose Combinations with Cilostazol, Metoprolol and Valsartan. Pharmacology 2018;101(1-2):54-63.
Steven S, Dib M, Hausding M, Kashani F, Oelze M, Kröller-Schön S, Hanf A, Daub S, Roohani S, Gramlich Y, Lutgens E, Schulz E, Becker C, Lackner KJ, Kleinert H, Knosalla C, Niesler B, Wild PS, Münzel T, Daiber A. CD40L controls obesity-associated vascular inflammation, oxidative stress, and endothelial dysfunction in high fat diet-treated and db/db mice. Cardiovasc Res 2018;114(2):312-323.
Keller K, Münzel T, Ostad MA. Sex-specific differences in mortality and the obesity paradox of patients with myocardial infarction ages >70 y. Nutrition 2018;46:124-130.
Wang X, Hausding M, Weng SY, Kim YO, Steven S, Klein T, Daiber A, Schuppan D. Gliptins Suppress Inflammatory Macrophage Activation to Mitigate Inflammation, Fibrosis, Oxidative Stress, and Vascular Dysfunction in Models of Nonalcoholic Steatohepatitis and Liver Fibrosis. Antioxid Redox Signal 2018;28(2):87-109.

Reviews 2018

Graf C, Ruf W. Tissue factor as a mediator of coagulation and signaling in cancer and chronic inflammation. Thromb Res 2018;164 Suppl 1:S143-S147
Saffarzadeh M. Neutrophil Extracellular Traps as a Drug Target to Counteract Chronic and Acute Inflammation. Curr Pharm Biotechnol 2018;19(15):1196-1202.
Reinhardt C. The Involvement of Toll-like Receptor-2 in Arterial Thrombus Formation. Hamostaseologie 2018;38(4):223-228.
Carnevale D, Wenzel P. Mechanical stretch on endothelial cells interconnects innate and adaptive immune response in hypertension. Cardiovasc Res 2018;114(11):1432-1434.
Kiouptsi K, Reinhardt C. Contribution of the commensal microbiota to atherosclerosis and arterial thrombosis. Br J Pharmacol 2018;175(24):4439-4449.
Subramaniam S, Kanse SM, Kothari H, Reinhardt C, Fletcher C. Post-transcriptional, post-translational and pharmacological regulation of tissue factor pathway inhibitor. Blood Coagul Fibrinolysis 2018;29(8):668-682.
Westmeier D, Hahlbrock A, Reinhardt C, Fröhlich-Nowoisky J, Wessler S, Vallet C, Pöschl U, Knauer SK, Stauber RH. Nanomaterial-microbe cross-talk: physicochemical principles and (patho)biological consequences. Chem Soc Rev 2018;47(14):5312-5337.
Barco S, Konstantinides SV. Pulmonary Embolism: Contemporary Medical Management and Future Perspectives. Ann Vasc Dis 2018;11(3):265-276.
Nguyen TS, Lapidot T, Ruf W. Extravascular coagulation in hematopoietic stem and progenitor cell regulation. Blood 2018;132(2):123-131.
Ruf W. ISTH 2017 Berlin revisited. Res Pract Thromb Haemost 2018;2(1):17-18.
Zelaya H, Rothmeier AS, Ruf W. Tissue factor at the crossroad of coagulation and cell signaling. J Thromb Haemost 2018;16(10):1941-1952.
Kiouptsi K, Ruf W, Reinhardt C. Microbiota-Derived Trimethylamine. Circ Res 2018;123(10):1112-1114.
Prochaska JH, Wild PS. Traffic-associated air pollution as a risk factor for cancer in individuals with coronary artery disease. Eur J Prev Cardiol 2018:2047487318768942.
Ruf W. Proteases, Protease-Activated Receptors, and Atherosclerosis. Arterioscler Thromb Vasc Biol 2018;38(6):1252-1254.
Konstantinides SV. Diagnosis of Cerebral Venous Thrombosis: The Complementary Value of Imaging Methods. Thromb Haemost 2018;118(6):956.
Huisman MV, Barco S, Cannegieter SC, Le Gal G, Konstantinides SV, Reitsma PH, Rodger M, Vonk Noordegraaf A, Klok FA. Pulmonary embolism. Nat Rev Dis Primers 2018;4:18028.
Konstantinides SV. Detection and treatment of chronic thromboembolic pulmonary hypertension: Still a lot of homework to do. Hellenic J Cardiol 2018;59(1):24-25.
Klok FA, Barco S, Konstantinides SV. Evaluation of VTE-BLEED for predicting intracranial or fatal bleeding in stable anticoagulated patients with venous thromboembolism. Eur Respir J 2018;51(4).
Prochaska JH, Arnold N, Jünger C, Münzel T, Wild PS. [Prevention of cardiovascular diseases]. Herz 2018;43(1):87-100.
Ascher S, Reinhardt C. The gut microbiota: An emerging risk factor for cardiovascular and cerebrovascular disease. Eur J Immunol 2018;48(4):564-575.
Konstantinides SV, Barco S. Prevention of early complications and late consequences after acute pulmonary embolism: Focus on reperfusion techniques. Thromb Res 2018;164:163-169.
Klok FA, Barco S. Follow-up after acute Pulmonary Embolism. Hamostaseologie 2018;38(1):22-32.
Münzel T, Daiber A. Inorganic nitrite and nitrate in cardiovascular therapy: A better alternative to organic nitrates as nitric oxide donors? Vascul Pharmacol 2018;102:1-10.
Münzel T, Daiber A. The potential of aldehyde dehydrogenase 2 as a therapeutic target in cardiovascular disease. Expert Opin Ther Targets 2018;22(3):217-231.
Spronk HMH, Padro T, Siland JE, Prochaska JH, Winters J, van der Wal AC, Posthuma JJ, Lowe G, d'Alessandro E, Wenzel P, Coenen DM, Reitsma PH, Ruf W, van Gorp RH, Koenen RR, Vajen T, Alshaikh NA, Wolberg AS, Macrae FL, Asquith N, Heemskerk J, Heinzmann A, Moorlag M, Mackman N, van der Meijden P, Meijers JCM, Heestermans M, Renne T, Dolleman S, Chayoua W, Ariens RAS, Baaten CC, Nagy M, Kuliopulos A, Posma JJ, Harrison P, Vries MJ, Crijns H, Dudink E, Buller HR, Henskens YMC, Sjalander A, Zwaveling S, Erkuner O, Eikelboom JW, Gulpen A, Peeters F, Douxfils J, Olie RH, Baglin T, Leader A, Schotten U, Scaf B, van Beusekom HMM, Mosnier LO, van der Vorm L, Declerck P, Visser M, Dippel DWJ, Strijbis VJ, Pertiwi K, Ten Cate-Hoek AJ, Ten Cate H. Atherothrombosis and Thromboembolism: Position Paper from the Second Maastricht Consensus Conference on Thrombosis. Thromb Haemost 2018;118(2):229-250.
Barco S, Konstantinides S, Huisman MV, Klok FA. Diagnosis of recurrent venous thromboembolism. Thromb Res 2018;163:229-235.
Subramaniam S, Scharrer I. Procoagulant activity during viral infections. Front Biosci (Landmark Ed) 2018;23:1060-1081.
Khandagale A, Reinhardt C. Gut microbiota - architects of small intestinal capillaries. Front Biosci (Landmark Ed) 2018;23:752-766.

Editorials und Fachbeiträge 2018

Konstantinides SV. Introduction to the Special Issue: 'Update on Pulmonary Embolism'. Hamostaseologie 2018;38(2):71-72.
Kossmann S, Wenzel P. Under Pressure: A New Role for CD11c(+) Myeloid Cells in Hypertension. Hypertension 2018;71(4):557-558.
Brandt M, Wenzel P. Alcohol puts the heart under pressure: Acetaldehyde activates a localized renin angiotensin aldosterone system within the myocardium in alcoholic cardiomyopathy. Int J Cardiol 2018;257:220-221.

Originalartikel 2017

Wilton P, Steidel M, Krczal G, Hermanns I, Pfützner A, Konnerth A, Boonrod K. Identification of Highly Specific scFvs against Total Adiponectin for Diagnostic Purposes. Biology (Basel) 2017;6(2).
Wild J, Gori T, Münzel T, Wenzel P. Successful percutaneous coronary intervention for an in-stent chronic total occlusion in a patient with dextrocardia: a case report. BMC Cardiovasc Disord 2017;17(1):281.
Lagrange J, Didelot M, Mohamadi A, Walton LA, Bloemen S, de Laat B, Louis H, Thornton SN, Derby B, Sherratt MJ, Feve B, Challande P, Akhtar R, Cruickshank JK, Lacolley P, Regnault V. Implication of Free Fatty Acids in Thrombin Generation and Fibrinolysis in Vascular Inflammation in Zucker Rats and Evolution with Aging. Front Physiol 2017;8:949.
Klok FA, Ageno W, Barco S, Binder H, Brenner B, Duerschmied D, Empen K, Faggiano P, Ficker JH, Galiè N, Ghuysen A, Held M, Heydenreich N, Huisman MV, Jiménez D, Kozak M, Lang IM, Lankeit M, Münzel T, Petris A, Pruszczyk P, Quitzau K, Schellong S, Schmidt KH, Stefanovic BS, Verschuren F, Wolf-Puetz A, Meyer G, Konstantinides SV, Investigators P-. Dabigatran after Short Heparin Anticoagulation for Acute Intermediate-Risk Pulmonary Embolism: Rationale and Design of the Single-Arm PEITHO-2 Study. Thromb Haemost 2017;117(12):2425-2434.
Stetzenbach M, Schnorbus B, Sagoschen I, Bleser W, Legner D, Stürer A. [Acute Monkshood Intoxication Requiring Acute Resuscitation in Suicidal Intent]. Anasthesiol Intensivmed Notfallmed Schmerzther 2017;52(9):641-644.
Seiler E, Limacher A, Mean M, Beer HJ, Osterwalder J, Frauchiger B, Righini M, Aschwanden M, Matter CM, Banyai M, Kucher N, Staub D, Lämmle B, Rodondi N, Squizzato A, Aujesky D. Derivation and validation of a novel bleeding risk score for elderly patients with venous thromboembolism on extended anticoagulation. Thromb Haemost 2017;117(10).
Lankeit M, Krieg V, Hobohm L, Kölmel S, Liebetrau C, Konstantinides S, Hamm CW, Mayer E, Wiedenroth CB, Guth S. Pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension. J Heart Lung Transplant 2017.
Cheung YW, Barco S, Mathot RAA, van den Dool EJ, Stroobants AK, Serlie MJ, Middeldorp S, Coppens M. Pharmacokinetics of dabigatran etexilate and rivaroxaban in patients with short bowel syndrome requiring parenteral nutrition: The PDER PAN study. Thromb Res 2017;160:76-82.
Barco S, Pomero F, Di Minno MND, Tamborini Permunian E, Malato A, Pasca S, Barillari G, Fenoglio L, Siragusa S, Di Minno G, Ageno W, Dentali F. Clinical course of patients with symptomatic isolated superficial vein thrombosis: the ICARO follow-up study. J Thromb Haemost 2017;15(11):2176-2183.
Keller K, Beule J, Balzer JO, Dippold W. Renal function as a cofactor for risk stratification and short-term outcome in acute pulmonary embolism. Exp Gerontol 2017;100:11-16.
Marquardt A, Al-Dabet MM, Ghosh S, Kohli S, Manoharan J, ElWakiel A, Gadi I, Bock F, Nazir S, Wang H, Lindquist JA, Nawroth PP, Madhusudhan T, Mertens PR, Shahzad K, Isermann B. Farnesoid X Receptor Agonism Protects against Diabetic Tubulopathy: Potential Add-On Therapy for Diabetic Nephropathy. J Am Soc Nephrol 2017;28(11):3182-3189.
Schnorbus B, Wiebe J, Capodanno D, Brugaletta S, Geraci S, Mehilli J, Latib A, Lesiak M, Jensen C, Mattesini A, Münzel T, Capranzano P, Di Mario C, Naber C, Araszkiewicz A, Colombo A, Caramanno G, Sabate M, Tamburino C, Nef H, Gori T. Twelve-month outcomes after bioresorbable vascular scaffold implantation in patients with acute coronary syndromes. Data from the European Multicenter GHOST-EU Extended Registry. EuroIntervention 2017;13(9):e1104-e1111.
Müller-Calleja N, Hollerbach A, Hauser F, Canisius A, Orning C, Lackner KJ. Antiphospholipid antibody-induced cellular responses depend on epitope specificity : implications for treatment of antiphospholipid syndrome. J Thromb Haemost 2017;15(12):2367-2376.
Beutel ME, Brähler E, Wiltink J, Michal M, Klein EM, Jünger C, Wild PS, Münzel T, Blettner M, Lackner K, Nickels S, Tibubos AN. Emotional and tangible social support in a German population-based sample: Development and validation of the Brief Social Support Scale (BS6). PLoS One 2017;12(10):e0186516.
Schuster AK, Pfeiffer N, Nickels S, Schulz A, Wild PS, Blettner M, Lackner K, Beutel ME, Münzel T, Vossmerbaeumer U. Steeper Iris Conicity Is Related to a Shallower Anterior Chamber: The Gutenberg Health Study. J Ophthalmol 2017;2017:2190347.
Steven S, Dib M, Roohani S, Kashani F, Münzel T, Daiber A. Time Response of Oxidative/Nitrosative Stress and Inflammation in LPS-Induced Endotoxaemia-A Comparative Study of Mice and Rats. Int J Mol Sci 2017;18(10).
Nielsen AL, Sorensen AB, Holmberg HL, Gandhi PS, Karlsson J, Buchardt J, Lamberth K, Kjelgaard-Hansen M, Ley CD, Sorensen BB, Ruf W, Olsen OH, Ostergaard H. Engineering of a membrane-triggered activity switch in coagulation factor VIIa. Proc Natl Acad Sci U S A 2017;114(47):12454-12459.
Jagodzinski A, Neumann JT, Ojeda F, Sorensen NA, Wild P, Münzel T, Zeller T, Westermann D, Blankenberg S. Cardiovascular Biomarkers in Hypertensive Patients with Medical Treatment-Results from the Randomized TEAMSTA Protect I Trial. Clin Chem 2017;63(12):1877-1885.
Gowert NS, Krüger I, Klier M, Donner L, Kipkeew F, Gliem M, Bradshaw NJ, Lutz D, Köber S, Langer H, Jander S, Jurk K, Frotscher M, Korth C, Bock HH, Elvers M. Loss of Reelin protects mice against arterial thrombosis by impairing integrin activation and thrombus formation under high shear conditions. Cell Signal 2017;40:210-221.
Schuster AK, Pfeiffer N, Schulz A, Hoehn R, Ponto KA, Wild PS, Blettner M, Beutel ME, Lackner KJ, Münzel T, Mirshahi A. Refractive, corneal and ocular residual astigmatism: distribution in a German population and age-dependency - the Gutenberg health study. Graefes Arch Clin Exp Ophthalmol 2017;255(12):2493-2501.
Jäckel S, Kiouptsi K, Lillich M, Hendrikx T, Khandagale A, Kollar B, Hörmann N, Reiss C, Subramaniam S, Wilms E, Ebner K, Brühl MV, Rausch P, Baines JF, Haberichter S, Lämmle B, Binder CJ, Jurk K, Ruggeri ZM, Massberg S, Walter U, Ruf W, Reinhardt C. Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2. Blood 2017;130(4):542-553.
Höhn R, Mirshahi A, Nickels S, Schulz A, Wild PS, Blettner M, Pfeiffer N. Cardiovascular medication and intraocular pressure: results from the Gutenberg Health Study. Br J Ophthalmol 2017;101(12):1633-1637.
Braenne I, Willenborg C, Tragante V, Kessler T, Zeng L, Reiz B, Kleinecke M, von Ameln S, Willer CJ, Laakso M, Wild PS, Zeller T, Wallentin L, Franks PW, Salomaa V, Dehghan A, Meitinger T, Samani NJ, Asselbergs FW, Erdmann J et al. (2017) A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors. Scientific reports 7: 10252
Nickels S, Schuster AK, Singer S, Wild PS, Laubert-Reh D, Schulz A, Finger RP, Michal M, Beutel ME, Münzel T, Lackner KJ, Pfeiffer N (2017) The National Eye Institute 25-Item Visual Function Questionnaire (NEI VFQ-25) - reference data from the German population-based Gutenberg Health Study (GHS). Health Qual Life Outcomes 15: 156
Zeller T, Schurmann C, Schramm K, Müller C, Kwon S, Wild PS, Teumer A, Herrington D, Schillert A, Iacoviello L, Kratzer A, Jagodzinski A, Karakas M, Ding J, Neumann JT, Kuulasmaa K, Gieger C, Kacprowski T, Schnabel RB, Roden M et al. (2017) Transcriptome-Wide Analysis Identifies Novel Associations With Blood Pressure. Hypertension 70: 743-750
Trinchero A, Schotten S, Lämmle B, Pitton MB (2017) May-Thurner syndrome: missed diagnosis and missed early treatment? Hamostaseologie 37: 184-185
Hubert A, Bochenek ML, Schutz E, Gogiraju R, Münzel T, Schäfer K (2017) Selective Deletion of Leptin Signaling in Endothelial Cells Enhances Neointima Formation and Phenocopies the Vascular Effects of Diet-Induced Obesity in Mice. Arteriosclerosis, thrombosis, and vascular biology 37: 1683-1697
Schütz E, Bochenek ML, Riehl DR, Bosmann M, Münzel T, Konstantinides S, Schäfer K (2017) Absence of transforming growth factor beta 1 in murine platelets reduces neointima formation without affecting arterial thrombosis. Thrombosis and haemostasis 117: 1782-1797
Roewe J, Higer M, Riehl DR, Gericke A, Radsak MP, Bosmann M (2017) Neuroendocrine Modulation of IL-27 in Macrophages. Journal of immunology 199(7):2503-2514
Kamikubo Y, Mendolicchio GL, Zampolli A, Marchese P, Rothmeier AS, Orje JN, Gale AJ, Krishnaswamy S, Gruber A, Ostergaard H, Petersen LC, Ruf W, Ruggeri ZM (2017) Selective factor VIII activation by the tissue factor-factor VIIa-factor Xa complex. Blood 130: 1661-1670
Alflen A, Prüfer S, Ebner K, Reuter S, Aranda Lopez P, Scharrer I, Banno F, Stassen M, Schild H, Jurk K, Bosmann M, Beckert H, Radsak MP (2017) ADAMTS-13 regulates neutrophil recruitment in a mouse model of invasive pulmonary aspergillosis. Scientific reports 7: 7184
Kiouptsi K, Grill A, Mann A, Döhrmann M, Lillich M, Jäckel S, Malinarich F, Formes H, Manukyan D, Subramaniam S, Khandagale A, Karwot C, Thal SC, Bosmann M, Scharrer I, Jurk K, Reinhardt C (2017) Mice deficient in the anti-haemophilic coagulation factor VIII show increased von Willebrand factor plasma levels. PloS one 12: e0183590
Kiouptsi K, Gambaryan S, Walter E, Walter U, Jurk K, Reinhardt C (2017) Hypoxia impairs agonist-induced integrin αIIbβ3 activation and platelet aggregation. Sci Rep. 7(1):7621
Klier M, Gowert NS, Jäckel S, Reinhardt C, Elvers M (2017) Phospholipase D1 is a regulator of platelet-mediated inflammation. Cell Signal 38: 171-181
Schulz A, Zöller D, Nickels S, Beutel ME, Blettner M, Wild PS, Binder H(2017) Simulation of complex data structures for planning of studies with focus on biomarker comparison. BMC Med Res Methodol 17: 90
Grechowa I, Horke S, Wallrath A, Vahl CF, Dorweiler B (2017) Human neutrophil elastase induces endothelial cell apoptosis by activating the PERK-CHOP branch of the unfolded protein response. FASEB journal 31: 3868-3881
Mean M, Limacher A, Stalder O, Angelillo-Scherrer A, Alberio L, Fontana P, Beer HJ, Rodondi N, Lämmle B, Aujesky D (2017) Do Factor V Leiden and Prothrombin G20210A Mutations Predict Recurrent Venous Thromboembolism in Older Patients? Am J Med 130: 1220 e17-1220 e22
Madhusudhan T, Wang H, Ghosh S, Dong W, Kumar V, Al-Dabet MM, Manoharan J, Nazir S, Elwakiel A, Bock F, Kohli S, Marquardt A, Sögüt I, Shahzad K, Müller AJ, Esmon CT, Nawroth PP, Reiser J, Chavakis T, Ruf W, Isermann B (2017) Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function. Blood 130: 1445-1455
Chrysanthopoulou A, Kambas K, Stakos D, Mitroulis I, Mitsios A, Vidali V, Angelidou I, Bochenek M, Arelaki S, Arampatzioglou A, Galani IE, Skendros P, Couladouros EA, Konstantinides S, Andreakos E, Schäfer K, Ritis K (2017) Interferon lambda1/IL-29 and inorganic polyphosphate are novel regulators of neutrophil-driven thromboinflammation. J Pathol 243: 111-122
Dentali F, Pegoraro S, Barco S, di Minno MND, Mastroiacovo D, Pomero F, Lodigiani C, Bagna F, Sartori M, Barillari G, Mumoli N, Napolitano M, Passamonti SM, Benedetti R, Ageno W, Di Nisio M (2017) Clinical course of isolated distal deep vein thrombosis in patients with active cancer: a multicenter cohort study. Journal of thrombosis and haemostasis 15: 1757-1763
Fattahi F, Kalbitz M, Malan EA, Abe E, Jajou L, Huber-Lang MS, Bosmann M, Russell MW, Zetoune FS, Ward PA (2017) Complement-induced activation of MAPKs and Akt during sepsis: role in cardiac dysfunction. FASEB journal 31(9):4129-4139
Hoeper MM, Lam CS, Vachiery JL, Bauersachs J, Gerges C, Lang IM, Bonderman D, Olsson KM, Gibbs JS, Dorfmuller P, Guazzi M, Galie N, Manes A, Handoko ML, Vonk-Noordegraaf A, Lankeit M, Konstantinides S, Wachter R, Opitz C, Rosenkranz S (2017) Pulmonary hypertension in heart failure with preserved ejection fraction: a plea for proper phenotyping and further research. European heart journal 7;38(38):2869-2873
Arnold N, Gori T, Schnabel RB, Schulz A, Prochaska JH, Zeller T, Binder H, Pfeiffer N, Beutel M, Espinola-Klein C, Lackner KJ, Blankenberg S, Münzel T, Wild PS (2017) Relation between Arterial Stiffness and Markers of Inflammation and Hemostasis - Data from the Population-based Gutenberg Health Study. Scientific reports 7: 6346
Keller K, Stelzer K, Ostad MA, Post F (2017) Impact of exaggerated blood pressure response in normotensive individuals on future hypertension and prognosis: Systematic review according to PRISMA guideline. Advances in medical sciences 62: 317-329
Rukoyatkina N, Butt E, Subramanian H, Nikolaev VO, Mindukshev I, Walter U, Gambaryan S, Benz PM (2017) Protein kinase A activation by the anti-cancer drugs ABT-737 and thymoquinone is caspase-3-dependent and correlates with platelet inhibition and apoptosis. Cell Death Dis 8: e2898
Ponto KA, Werner DJ, Wiedemer L, Laubert-Reh D, Schuster AK, Nickels S, Höhn R, Schulz A, Binder H, Beutel M, Lackner KJ, Wild PS, Pfeiffer N, Mirshahi A (2017) Retinal vessel metrics: normative data and their use in systemic hypertension: results from the Gutenberg Health Study. J Hypertens 35: 1635-1645
Steven S, Oelze M, Hanf A, Kröller-Schön S, Kashani F, Roohani S, Welschof P, Kopp M, Godtel-Armbrust U, Xia N, Li H, Schulz E, Lackner KJ, Wojnowski L, Bottari SP, Wenzel P, Mayoux E, Münzel T, Daiber A (2017) The SGLT2 inhibitor empagliflozin improves the primary diabetic complications in ZDF rats. Redox Biol 13: 370-385
Rothmeier AS, Marchese P, Langer F, Kamikubo Y, Schaffner F, Cantor J, Ginsberg MH, Ruggeri ZM, Ruf W (2017) Tissue Factor Prothrombotic Activity Is Regulated by Integrin-arf6 Trafficking. Arteriosclerosis, thrombosis, and vascular biology 37: 1323-1331
Prochaska JH, Frank B, Nagler M, Lamparter H, Weisser G, Schulz A, Eggebrecht L, Göbel S, Arnold N, Panova-Noeva M, Hermanns I, Pinto A, Konstantinides S, Ten Cate H, Lackner KJ, Münzel T, Espinola-Klein C, Wild PS (2017) Age-related diagnostic value of D-dimer testing and the role of inflammation in patients with suspected deep vein thrombosis. Scientific reports 7: 4591
Prochaska JH, Göbel S, Keller K, Coldewey M, Ullmann A, Lamparter H, Schulz A, Schinzel H, Bickel C, Lauterbach M, Michal M, Hardt R, Binder H, Espinola-Klein C, Lackner KJ, Ten Cate H, Münzel T, Wild PS (2017) e-Health-based management of patients receiving oral anticoagulation therapy: results from the observational thrombEVAL study. Journal of thrombosis and haemostasis 15: 1375-1385
Sag CM, Schnelle M, Zhang J, Murdoch CE, Kossmann S, Protti A, Santos CXC, Sawyer G, Zhang X, Mongue-Din H, Richards DA, Brewer AC, Prysyazhna O, Maier LS, Wenzel P, Eaton PJ, Shah AM (2017) Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure. Circulation 135: 2163-2177
Barco S, Corti M, Trinchero A, Picchi C, Ambaglio C, Konstantinides SV, Dentali F, Barone M (2017) Survival and recurrent venous thromboembolism in patients with first proximal or isolated distal deep vein thrombosis and no pulmonary embolism. Journal of thrombosis and haemostasis 15: 1436-1442
Kargapolova Y, Levin M, Lackner K, Danckwardt S (2017) sCLIP-an integrated platform to study RNA-protein interactomes in biomedical research: identification of CSTF2tau in alternative processing of small nuclear RNAs. Nucleic Acids Res 45: 6074-6086
Klok FA, Barco S, Konstantinides SV (2017) External validation of the VTE-BLEED score for predicting major bleeding in stable anticoagulated patients with venous thromboembolism. Thrombosis and haemostasis 117: 1164-1170
Mumoli N, Barco S, Cei M, Giorgi-Pierfranceschi M, Campanini M, Fontanella A, Ageno W, Dentali F (2017) Prevention and treatment of venous thromboembolism in patients with solid brain neoplasms: results of a survey among Italian physicians. Internal and emergency medicine 12: 437-443
Sinning C, Ojeda F, Wild PS, Schnabel RB, Schwarzl M, Ohdah S, Lackner KJ, Pfeiffer N, Michal M, Blettner M, Münzel T, Kempf T, Wollert KC, Kuulasmaa K, Blankenberg S, Salomaa V, Westermann D, Zeller T (2017) Midregional proadrenomedullin and growth differentiation factor-15 are not influenced by obesity in heart failure patients. Clinical research in cardiology 106: 401-410
Barco S, Atema JJ, Coppens M, Serlie MJ, Middeldorp S (2017) Anticoagulants for the prevention and treatment of catheter-related thrombosis in adults and children on parenteral nutrition: a systematic review and critical appraisal. Blood Transfus 15: 369-377
Steven S, Jurk K, Kopp M, Kröller-Schön S, Mikhed Y, Schwierczek K, Roohani S, Kashani F, Oelze M, Klein T, Tokalov S, Danckwardt S, Strand S, Wenzel P, Münzel T, Daiber A (2017) Glucagon-like peptide-1 receptor signalling reduces microvascular thrombosis, nitro-oxidative stress and platelet activation in endotoxaemic mice. British journal of pharmacology 174: 1620-1632
Beutel ME, Klein EM, Brähler E, Reiner I, Jünger C, Michal M, Wiltink J, Wild PS, Münzel T, Lackner KJ, Tibubos AN (2017) Loneliness in the general population: prevalence, determinants and relations to mental health. BMC psychiatry 17: 97
Brant LC, Wang N, Ojeda FM, LaValley M, Barreto SM, Benjamin EJ, Mitchell GF, Vasan RS, Palmisano JN, Münzel T, Blankenberg S, Wild PS, Zeller T, Ribeiro AL, Schnabel RB, Hamburg NM (2017) Relations of Metabolically Healthy and Unhealthy Obesity to Digital Vascular Function in Three Community-Based Cohorts: A Meta-Analysis. Journal of the American Heart Association 6
Marx-Gross S, Laubert-Reh D, Schneider A, Höhn R, Mirshahi A, Münzel T, Wild PS, Beutel ME, Blettner M, Pfeiffer N (2017) The Prevalence of Glaucoma in Young People. Deutsches Arzteblatt international 114: 204-210
Rose DM, Seidler A, Nübling M, Latza U, Brähler E, Klein EM, Wiltink J, Michal M, Nickels S, Wild PS, König J, Claus M, Letzel S, Beutel ME (2017) Associations of fatigue to work-related stress, mental and physical health in an employed community sample. BMC psychiatry 17: 167
Schuster AK, Pfeiffer N, Schulz A, Nickels S, Höhn R, Wild PS, Blettner M, Münzel T, Beutel ME, Lackner KJ, Vossmerbaeumer U (2017) The impact of pseudophakia on vision-related quality of life in the general population - The Gutenberg Health Study. Aging 9: 1030-1040
Wild PS, Felix JF, Schillert A, Teumer A, Chen MH, Leening MJG, Volker U, Grossmann V, Brody JA, Irvin MR, Shah SJ, Pramana S, Lieb W, Schmidt R, Stanton AV, Malzahn D, Smith AV, Sundstrom J, Minelli C, Ruggiero D et al. (2017) Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function. The Journal of clinical investigation 127: 1798-1812
Stein J, Steven S, Bros M, Sudowe S, Hausding M, Oelze M, Münzel T, Grabbe S, Reske-Kunz A, Daiber A (2017) Role of Protein Kinase C and Nox2-Derived Reactive Oxygen Species Formation in the Activation and Maturation of Dendritic Cells by Phorbol Ester and Lipopolysaccharide. Oxid Med Cell Longev 2017: 4157213
Falter T, Schmitt V, Herold S, Weyer V, von Auer C, Wagner S, Hefner G, Beutel M, Lackner K, Lämmle B, Scharrer I (2017) Depression and cognitive deficits as long-term consequences of thrombotic thrombocytopenic purpura. Transfusion 57: 1152-1162
Lorenz K, Scheller Y, Bell K, Grus F, Ponto KA, Bock F, Cursiefen C, Flach J, Gehring M, Peto T, Silva R, Tal Y, Pfeiffer N (2017) A prospective, randomised, placebo-controlled, double-masked, three-armed, multicentre phase II/III trial for the Study of a Topical Treatment of Ischaemic Central Retinal Vein Occlusion to Prevent Neovascular Glaucoma - the STRONG study: study protocol for a randomised controlled trial. Trials 18: 128
Steven S, Oelze M, Brandt M, Ullmann E, Kröller-Schön S, Heeren T, Tran LP, Daub S, Dib M, Stalleicken D, Wenzel P, Münzel T, Daiber A (2017) Pentaerythritol Tetranitrate In Vivo Treatment Improves Oxidative Stress and Vascular Dysfunction by Suppression of Endothelin-1 Signaling in Monocrotaline-Induced Pulmonary Hypertension. Oxid Med Cell Longev 2017: 4353462
Luque Ramos A, Ohlmeier C, Enders D, Linder R, Horenkamp-Sonntag D, Prochaska JH, Mikolajczyk R, Garbe E (2017) Initiation and duration of dual antiplatelet therapy after inpatient percutaneous coronary intervention with stent implantation in Germany: An electronic healthcare database cohort study. Z Evid Fortbild Qual Gesundhwes 120: 31-38
Panova-Noeva M, Arnold N, Hermanns MI, Prochaska JH, Schulz A, Spronk HM, Binder H, Pfeiffer N, Beutel M, Blankenberg S, Zeller T, Lotz J, Münzel T, Lackner KJ, Ten Cate H, Wild PS (2017) Mean Platelet Volume and Arterial Stiffness - Clinical Relationship and Common Genetic Variability. Scientific reports 7: 40229
Magnussen C, Ojeda FM, Rzayeva N, Zeller T, Sinning CR, Pfeiffer N, Beutel M, Blettner M, Lackner KJ, Blankenberg S, Münzel T, Rabe KF, Wild PS, Schnabel RB, Gutenberg Health Study i (2017) FEV1 and FVC predict all-cause mortality independent of cardiac function - Results from the population-based Gutenberg Health Study. International journal of cardiology 234: 64-68
de Vries PS, Sabater-Lleal M, Chasman DI, Trompet S, Ahluwalia TS, Teumer A, Kleber ME, Chen MH, Wang JJ, Attia JR, Marioni RE, Steri M, Weng LC, Pool R, Grossmann V, Brody JA, Venturini C, Tanaka T, Rose LM, Oldmeadow C, [...], Wild PS et al. (2017) Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study. PloS one 12: e0167742
Springelkamp H, Iglesias AI, Mishra A, Hohn R, Wojciechowski R, Khawaja AP, Nag A, Wang YX, Wang JJ, Cuellar-Partida G, Gibson J, Bailey JN, Vithana EN, Gharahkhani P, Boutin T, Ramdas WD, Zeller T, Luben RN, Yonova-Doing E, Viswanathan A, […], Wild PS et al. (2017) New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics. Human molecular genetics 26: 438-453
Sennblad B, Basu S, Mazur J, Suchon P, Martinez-Perez A, van Hylckama Vlieg A, Truong V, Li Y, Gadin JR, Tang W, Grossman V, de Haan HG, Handin N, Silveira A, Souto JC, Franco-Cereceda A, Morange PE, Gagnon F, Soria JM, Eriksson P, Hamsten A, Maegdefessel L, Rosendaal FR, Wild P, Folsom AR, Tregouet DA, Sabater-Lleal M (2017) Genome-wide association study with additional genetic and post-transcriptional analyses reveals novel regulators of plasma factor XI levels. Human molecular genetics 26: 637-649
Loroch S, Trabold K, Gambaryan S, Reiss C, Schwierczek K, Fleming I, Sickmann A, Behnisch W, Zieger B, Zahedi RP, Walter U, Jurk K (2017) Alterations of the platelet proteome in type I Glanzmann thrombasthenia caused by different homozygous delG frameshift mutations in ITGA2B. Thrombosis and haemostasis 117: 556-569
Beck F, Geiger J, Gambaryan S, Solari FA, Dell'Aica M, Loroch S, Mattheij NJ, Mindukshev I, Potz O, Jurk K, Burkhart JM, Fufezan C, Heemskerk JW, Walter U, Zahedi RP, Sickmann A (2017) Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition. Blood 129: e1-e12
Subramaniam S, Jurk K, Hobohm L, Jäckel S, Saffarzadeh M, Schwierczek K, Wenzel P, Langer F, Reinhardt C, Ruf W (2017) Distinct contributions of complement factors to platelet activation and fibrin formation in venous thrombus development. Blood 129: 2291-2302
Kossmann S, Lagrange J, Jäckel S, Jurk K, Ehlken M, Schönfelder T, Weihert Y, Knorr M, Brandt M, Xia N, Li H, Daiber A, Oelze M, Reinhardt C, Lackner K, Gruber A, Monia B, Karbach SH, Walter U, Ruggeri ZM, Renné T, Ruf W, Münzel T, Wenzel P (2017) Platelet-localized FXI promotes a vascular coagulation-inflammatory circuit in arterial hypertension. Sci Transl Med 9
Reiner MF, Akhmedov A, Stivala S, Keller S, Gaul DS, Bonetti NR, Savarese G, Glanzmann M, Zhu C, Ruf W, Yang Z, Matter CM, Luscher TF, Camici GG, Beer JH (2017) Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression. Cardiovascular research 113: 61-69
Bochenek ML, Rosinus NS, Lankeit M, Hobohm L, Bremmer F, Schutz E, Klok FA, Horke S, Wiedenroth CB, Münzel T, Lang IM, Mayer E, Konstantinides S, Schäfer K (2017) From thrombosis to fibrosis in chronic thromboembolic pulmonary hypertension. Thrombosis and haemostasis 117: 769-783
van Rooij FJ, Qayyum R, Smith AV, Zhou Y, Trompet S, Tanaka T, Keller MF, Chang LC, Schmidt H, Yang ML, Chen MH, Hayes J, Johnson AD, Yanek LR, Mueller C, Lange L, Floyd JS, Ghanbari M, Zonderman AB, Jukema JW, [...] Wild PS, [...] et al. (2017) Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis. Am J Hum Genet 100: 51-63
Panova-Noeva M, Arnold N, Hermanns MI, Prochaska JH, Schulz A, Spronk HM, Binder H, Pfeiffer N, Beutel M, Blankenberg S, Zeller T, Lotz J, Münzel T, Lackner KJ, Ten Cate H, Wild PS (2017) Mean Platelet Volume and Arterial Stiffness - Clinical Relationship and Common Genetic Variability. Scientific reports 7: 40229
Busch CJ, Hendrikx T, Weismann D, Jäckel S, Walenbergh SM, Rendeiro AF, Weisser J, Puhm F, Hladik A, Göderle L, Papac-Milicevic N, Haas G, Millischer V, Subramaniam S, Knapp S, Bennett KL, Bock C, Reinhardt C, Shiri-Sverdlov R, Binder CJ (2017) Malondialdehyde epitopes are sterile mediators of hepatic inflammation in hypercholesterolemic mice. Hepatology 65: 1181-1195
Konstantinides SV, Vicaut E, Danays T, Becattini C, Bertoletti L, Beyer-Westendorf J, Bouvaist H, Couturaud F, Dellas C, Duerschmied D, Empen K, Ferrari E, Galie N, Jimenez D, Kostrubiec M, Kozak M, Kupatt C, Lang IM, Lankeit M, Meneveau N et al. (2017) Impact of Thrombolytic Therapy on the Long-Term Outcome of Intermediate-Risk Pulmonary Embolism. Journal of the American College of Cardiology 69: 1536-1544
Müller-Calleja N, Manukyan D, Canisius A, Strand D, Lackner KJ (2017) Hydroxychloroquine inhibits proinflammatory signalling pathways by targeting endosomal NADPH oxidase. Ann Rheum Dis 76: 891-897
Sinning C, Kempf T, Schwarzl M, Lanfermann S, Ojeda F, Schnabel RB, Zengin E, Wild PS, Lackner KJ, Münzel T, Blankenberg S, Wollert KC, Zeller T, Westermann D (2017) Biomarkers for characterization of heart failure - Distinction of heart failure with preserved and reduced ejection fraction. International journal of cardiology 227: 272-277
Faller N, Limacher A, Mean M, Righini M, Aschwanden M, Beer JH, Frauchiger B, Osterwalder J, Kucher N, Lämmle B, Cornuz J, Angelillo-Scherrer A, Matter CM, Husmann M, Banyai M, Staub D, Mazzolai L, Hugli O, Rodondi N, Aujesky D (2017) Predictors and Causes of Long-Term Mortality in Elderly Patients with Acute Venous Thromboembolism: A Prospective Cohort Study. Am J Med 130: 198-206
Scully M, Cataland S, Coppo P, de la Rubia J, Friedman KD, Kremer Hovinga J, Lämmle B, Matsumoto M, Pavenski K, Sadler E, Sarode R, Wu H, International Working Group for Thrombotic Thrombocytopenic P (2017) Consensus on the standardization of terminology in thrombotic thrombocytopenic purpura and related thrombotic microangiopathies. Journal of thrombosis and haemostasis 15: 312-322
Barco S, Picchi C, Trinchero A, Middeldorp S, Coppens M (2017) Safety of prothrombin complex concentrate in healthy subjects. Br J Haematol 176: 664-666
Keller K, von Bardeleben RS, Ostad MA, Hobohm L, Münzel T, Konstantinides S, Lankeit M (2017) Temporal Trends in the Prevalence of Infective Endocarditis in Germany Between 2005 and 2014. Am J Cardiol 119: 317-322

Reviews 2017

Lankeit M. Always think of the right ventricle, even in "low-risk" pulmonary embolism. Eur Respir J 2017;50(6).
Lankeit M, Keller K, Tschöpe C, Pieske B. [Medicinal treatment of tricuspid valve regurgitation]. Herz 2017;42(7):634-643.
Schönfelder T, Jäckel S, Wenzel P (2017) Mouse models of deep vein thrombosis. Gefasschirurgie 22: 28-33
Schulman S, Ageno W, Konstantinides SV (2017) Venous thromboembolism: Past, present and future. Thrombosis and haemostasis 117: 1219-1229
Schäfer K, Drosos I, Konstantinides S (2017) Perivascular adipose tissue: epiphenomenon or local risk factor? Int J Obes 41: 1311-1323
Lackner KJ, Manukyan D, Müller-Calleja N (2017) Pathophysiological insights into the antiphospholipid syndrome. Hamostaseologie 37: 202-207
Jurk K (2017) Platelet granules - secretory and secretive. Hamostaseologie 37(3):208-210
Lutz J, Jurk K, Schinzel H (2017) Direct oral anticoagulants in patients with chronic kidney disease: patient selection and special considerations. Int J Nephrol Renovasc Dis 10: 135-143
Konstantinides SV (2017) Diagnosis of pulmonary embolism: progress after many YEARS. Lancet 390: 210-211
Lutz J, Jurk K (2017) Antiplatelet Agents and Anticoagulants in Patients with Chronic Kidney Disease - from Pathophysiology to Clinical Practice. Current pharmaceutical design 23: 1366-1376
Scholz-Kreisel P, Spix C, Blettner M, Eckerle S, Faber J, Wild P, Merzenich H, Hennewig U (2017) Prevalence of cardiovascular late sequelae in long-term survivors of childhood cancer: A systematic review and meta-analysis. Pediatr Blood Cancer 64
Lackner KJ, Manukyan D, Müller-Calleja N (2017) Endosomal Redox Signaling in the Antiphospholipid Syndrome. Curr Rheumatol Rep 19: 20
Kremer Hovinga JA, Coppo P, Lämmle B, Moake JL, Miyata T, Vanhoorelbeke K (2017) Thrombotic thrombocytopenic purpura. Nat Rev Dis Primers 3: 17020
Barco S, Konstantinides SV (2017) Catheter-directed thrombolysis for acute pulmonary embolism: Where do we stand? Lung India 34: 221-222
Barco S, Konstantinides SV (2017) Risk-adapted management of pulmonary embolism. Thrombosis research 151 Suppl 1: S92-S96
Wenzel P, Kossmann S, Münzel T, Daiber A (2017) Redox regulation of cardiovascular inflammation - Immunomodulatory function of mitochondrial and Nox-derived reactive oxygen and nitrogen species. Free Radic Biol Med
Lagrange J, Kossmann S, Wenzel P (2017) Assessment of Vascular Dysfunction and Inflammation Induced by Angiotensin II in Mice. Methods Mol Biol 1559: 439-453
Konstantinides SV, Barco S (2017) Systemic Thrombolytic Therapy for Acute Pulmonary Embolism: Who Is a Candidate? Semin Respir Crit Care Med 38: 56-65
Pagel O, Walter E, Jurk K, Zahedi RP (2017) Taking the stock of granule cargo: Platelet releasate proteomics. Platelets 28: 119-128
Gori T, Grünewald J (2017) Clinical career and research: are they mutually exclusive? European heart journal 38: 72-74

Editorials und Fachbeiträge 2017

Konstantinides SV. The Elusive Evidence for Inferior Vena Cava Filters to Prevent Pulmonary Embolism. J Am Coll Cardiol 2017;70(13):1598-1600.
Reinhardt C (2017) GAS6: Pouring GASoline Into the Inflammatory Inferno of Venous Thrombosis. Arteriosclerosis, thrombosis, and vascular biology 37: 1263-1265
Ruf W, Preissner KT (2017) State of the Art 2017. Journal of thrombosis and haemostasis 15: 1239
Lämmle B (2017) Opana ER-induced thrombotic microangiopathy. Blood 129: 808-809

Originalartikel 2016

Yost CC, Schwertz H, Cody MJ, Wallace JA, Campbell RA, Vieira-de-Abreu A, Araujo CV, Schubert S, Harris ES, Rowley JW, Rondina MT, Fulcher JM, Koening CL, Weyrich AS, Zimmerman GA (2016) Neonatal NET-inhibitory factor and related peptides inhibit neutrophil extracellular trap formation. The Journal of clinical investigation 126: 3783-3798
Klok FA, Hösel V, Clemens A, Yollo WD, Tilke C, Schulman S, Lankeit M, Konstantinides SV (2016) Prediction of bleeding events in patients with venous thromboembolism on stable anticoagulation treatment. The European respiratory journal 48: 1369-1376
Barco S, Heuschen CB, Salman B, Brekelmans MP, Serlie MJ, Middeldorp S, Coppens M (2016) Home parenteral nutrition-associated thromboembolic and bleeding events: results of a cohort study of 236 individuals. Journal of thrombosis and haemostasis 14: 1364-73
Barco S, Woersching AL, Spyropoulos AC, Piovella F, Mahan CE (2016) European Union-28: An annualised cost-of-illness model for venous thromboembolism. Thrombosis and haemostasis 115: 800-8
Jankowiak S, Backé E, Liebers F, Schulz A, Hegewald J, Garthus-Niegel S, Nübling M, Blankenberg S, Pfeiffer N, Lackner KJ, Beutel M, Blettner M, Münzel T, Wild PS, Seidler A, Letzel S, Latza U (2016) Current and cumulative night shift work and subclinical atherosclerosis: results of the Gutenberg Health Study. International archives of occupational and environmental health 89: 1169-1182
Landtwing V, Raykova A, Pezzino G, Beziat V, Marcenaro E, Graf C, Moretta A, Capaul R, Zbinden A, Ferlazzo G, Malmberg KJ, Chijioke O, Munz C (2016) Cognate HLA absence in trans diminishes human NK cell education. The Journal of clinical investigation 126: 3772-3782
Schwarzl M, Ojeda F, Zeller T, Seiffert M, Becher PM, Münzel T, Wild PS, Blettner M, Lackner KJ, Pfeiffer N, Beutel ME, Blankenberg S, Westermann D (2016) Risk factors for heart failure are associated with alterations of the LV end-diastolic pressure-volume relationship in non-heart failure individuals: data from a large-scale, population-based cohort. European heart journal 37: 1807-14
Kohli S, Ranjan S, Hoffmann J, Kashif M, Daniel EA, Al-Dabet MM, Bock F, Nazir S, Huebner H, Mertens PR, Fischer KD, Zenclussen AC, Offermanns S, Aharon A, Brenner B, Shahzad K, Ruebner M, Isermann B (2016) Maternal extracellular vesicles and platelets promote preeclampsia via inflammasome activation in trophoblasts. Blood 128: 2153-2164
Mirshahi A, Ponto KA, Laubert-Reh D, Rahm B, Lackner KJ, Binder H, Pfeiffer N, Unterrainer JM (2016) Myopia and Cognitive Performance: Results From the Gutenberg Health Study. Invest Ophthalmol Vis Sci 57: 5230-5236
Elflein HM, Rudy M, Lorenz K, Ponto KA, Scheurich A, Pitz S (2016) Charles Bonnet's syndrome: not only a condition of the elderly. Graefes Arch Clin Exp Ophthalmol 254: 1637-42
Beutel ME, Jünger C, Klein EM, Wild P, Lackner KJ, Blettner M, Banerjee M, Michal M, Wiltink J, Brahler E (2016) Depression, anxiety and suicidal ideation among 1(st) and 2(nd) generation migrants - results from the Gutenberg health study. BMC psychiatry 16: 288
Nagler M, Kremer Hovinga JA, Alberio L, Peter-Salonen K, von Tengg-Kobligk H, Lottaz D, Neerman-Arbez M, Lämmle B (2016) Thromboembolism in patients with congenital afibrinogenaemia. Long-term observational data and systematic review. Thrombosis and haemostasis 116: 722-32
Luther N, Shahneh F, Brähler M, Krebs F, Jäckel S, Subramaniam S, Stanger C, Schönfelder T, Kleis-Fischer B, Reinhardt C, Probst HC, Wenzel P, Schäfer K, Becker C (2016) Innate Effector-Memory T Cell Activation Regulates Post-Thrombotic Vein Wall Inflammation and Thrombus Resolution. Circ Res
Elbaz H, Peto T, Butsch C, Orouji E, Laubert-Reh D, Ponto KA, Binder H, Pfeiffer N, Mirshahi A (2016) PREVALENCE AND ASSOCIATIONS OF MYELINATED RETINAL NERVE FIBERS: Results From the Population-Based Gutenberg Health Study. Retina
Gogiraju R, Schroeter MR, Bochenek ML, Hubert A, Münzel T, Hasenfuss G, Schäfer K (2016) Endothelial deletion of protein tyrosine phosphatase-1B protects against pressure overload-induced heart failure in mice. Cardiovascular research 111: 204-16
Krüger M, Amort J, Wilgenbus P, Helmstädter JP, Grechowa I, Ebert J, Tenzer S, Moergel M, Witte I, Horke S (2016) The anti-apoptotic PON2 protein is Wnt/beta-catenin-regulated and correlates with radiotherapy resistance in OSCC patients. Oncotarget
Benz PM, Laban H, Zink J, Günther L, Walter U, Gambaryan S, Dib K (2016) Vasodilator-Stimulated Phosphoprotein (VASP)-dependent and -independent pathways regulate thrombin-induced activation of Rap1b in platelets. Cell Commun Signal 14: 21
Gambaryan S, Subramanian H, Kehrer L, Mindukshev I, Sudnitsyna J, Reiss C, Rukoyatkina N, Friebe A, Sharina I, Martin E, Walter U (2016) Erythrocytes do not activate purified and platelet soluble guanylate cyclases even in conditions favourable for NO synthesis. Cell Commun Signal 14: 16
Keller K, Beule J, Balzer JO, Dippold W (2016) Right bundle branch block and SQ-type patterns for risk stratification in acute pulmonary embolism. Journal of electrocardiology
Keller K, Beule J, Balzer JO, Dippold W (2016) Syncope and collapse in acute pulmonary embolism. The American journal of emergency medicine
Keller K, Stelzer K, Münzel T, Ostad MA (2016) Hypertension is strongly associated with false-positive bicycle exercise stress echocardiography testing results. Blood pressure: 1-9
Stark K, Philippi V, Stockhausen S, Busse J, Antonelli A, Miller M, Schubert I, Hoseinpour P, Chandraratne S, von Brühl ML, Gärtner F, Lorenz M, Agresti A, Coletti R, Antoine DJ, Heermann R, Jung K, Reese S, Laitinen I, Schwaiger M, Walch A, Sperandio M, Nawroth PP, Reinhardt C, Jäckel S, Bianchi ME, Massberg S. (2016) Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice. Blood
Baum C, Ojeda FM, Wild PS, Rzayeva N, Zeller T, Sinning CR, Pfeiffer N, Beutel M, Blettner M, Lackner KJ, Blankenberg S, Münzel T, Rabe KF, Schnabel RB, Gutenberg Health Study i (2016) Subclinical impairment of lung function is related to mild cardiac dysfunction and manifest heart failure in the general population. International journal of cardiology 218: 298-304
Beutel ME, Jünger C, Klein EM, Wild P, Lackner K, Blettner M, Binder H, Michal M, Wiltink J, Brähler E, Münzel T (2016) Noise Annoyance Is Associated with Depression and Anxiety in the General Population- The Contribution of Aircraft Noise. PloS one 11: e0155357
Blankenberg S, Salomaa V, Makarova N, Ojeda F, Wild P, Lackner KJ, Jorgensen T, Thorand B, Peters A, Nauck M, Petersmann A, Vartiainen E, Veronesi G, Brambilla P, Costanzo S, Iacoviello L, Linden G, Yarnell J, Patterson CC, Everett BM et al. (2016) Troponin I and cardiovascular risk prediction in the general population: the BiomarCaRE consortium. European heart journal
Garthus-Niegel S, Hegewald J, Seidler A, Nubling M, Espinola-Klein C, Liebers F, Wild PS, Latza U, Letzel S (2016) The Gutenberg health study: associations between occupational and private stress factors and work-privacy conflict. Bmc Public Health 16: 192
Garthus-Niegel S, Nubling M, Letzel S, Hegewald J, Wagner M, Wild PS, Blettner M, Zwiener I, Latza U, Jankowiak S, Liebers F, Seidler A (2016) Development of a mobbing short scale in the Gutenberg Health Study. International archives of occupational and environmental health 89: 137-46
Ghiassian SD, Menche J, Chasman DI, Giulianini F, Wang R, Ricchiuto P, Aikawa M, Iwata H, Müller C, Zeller T, Sharma A, Wild P, Lackner K, Singh S, Ridker PM, Blankenberg S, Barabasi AL, Loscalzo J (2016) Endophenotype Network Models: Common Core of Complex Diseases. Scientific reports 6: 27414
Kaller CP, Debelak R, Kostering L, Egle J, Rahm B, Wild PS, Blettner M, Beutel ME, Unterrainer JM (2016) Assessing Planning Ability Across the Adult Life Span: Population-Representative and Age-Adjusted Reliability Estimates for the Tower of London (TOL-F). Archives of clinical neuropsychology 31: 148-64
Manukyan D, Rossmann H, Schulz A, Zeller T, Pfeiffer N, Binder H, Münzel T, Beutel ME, Müller-Calleja N, Wild PS, Lackner KJ (2016) Distribution of antiphospholipid antibodies in a large population-based German cohort. Clinical chemistry and laboratory medicine 54: 1663-70
Müller-Calleja N, Rossmann H, Müller C, Wild P, Blankenberg S, Pfeiffer N, Binder H, Beutel ME, Manukyan D, Zeller T, Lackner KJ (2016) Antiphospholipid antibodies in a large population-based cohort: genome-wide associations and effects on monocyte gene expression. Thrombosis and haemostasis 116: 115-23
Müller C, Schillert A, Rothemeier C, Tregouet DA, Proust C, Binder H, Pfeiffer N, Beutel M, Lackner KJ, Schnabel RB, Tiret L, Wild PS, Blankenberg S, Zeller T, Ziegler A (2016) Removing Batch Effects from Longitudinal Gene Expression - Quantile Normalization Plus ComBat as Best Approach for Microarray Transcriptome Data. PloS one 11: e0156594
Ponto KA, Koenig J, Peto T, Lamparter J, Raum P, Wild PS, Lackner KJ, Pfeiffer N, Mirshahi A (2016) Prevalence of diabetic retinopathy in screening-detected diabetes mellitus: results from the Gutenberg Health Study (GHS). Diabetologia 59: 1913-9
Schuster AK, Pfeiffer N, Nickels S, Schulz A, Höhn R, Wild PS, Binder H, Münzel T, Beutel ME, Vossmerbaeumer U (2016) Distribution of Anterior Chamber Angle Width and Correlation With Age, Refraction, and Anterior Chamber Depth-The Gutenberg Health Study. Invest Ophthalmol Vis Sci 57: 3740-6
Unterrainer J, Michal M, Rahm B, Hadzibegovic J, Wild PS, Schulz A, Münzel T, Blettner M, Lackner K, Pfeiffer N, Blankenberg S, Denollet J, Beutel ME (2016) Association of Type D personality with cognitive functioning in individuals with and without cardiovascular disease - The Gutenberg Health Study. International journal of cardiology 214: 256-61
Becattini C, Agnelli G, Lankeit M, Masotti L, Pruszczyk P, Casazza F, Vanni S, Nitti C, Kamphuisen P, Vedovati MC, De Natale MG, Konstantinides S (2016) Acute pulmonary embolism: mortality prediction by the 2014 European Society of Cardiology risk stratification model. The European respiratory journal
Bleker SM, Buchmuller A, Chauleur C, Ainle FN, Donnelly J, Verhamme P, Jacobsen AF, Ganzevoort W, Prins M, Beyer-Westendorf J, DeSancho M, Konstantinides S, Pabinger I, Rodger M, Decousus H, Middeldorp S (2016) Low-molecular-weight heparin to prevent recurrent venous thromboembolism in pregnancy: Rationale and design of the Highlow study, a randomised trial of two doses. Thrombosis research 144: 62-68
Drosos I, Chalikias G, Pavlaki M, Kareli D, Epitropou G, Bougioukas G, Mikroulis D, Konstantinou F, Giatromanolaki A, Ritis K, Münzel T, Tziakas D, Konstantinides S, Schäfer K (2016) Differences between perivascular adipose tissue surrounding the heart and the internal mammary artery: possible role for the leptin-inflammation-fibrosis-hypoxia axis. Clinical research in cardiology : official journal of the German Cardiac Society
Kaymaz C, Öztürk S, Akbal Ö, Tanboga IH, Yilmaz F, Poci N, Türkday S, Hakgör A, Yildiz C, Aktemur T, Özdemir N, Konstantinides S (2016) Ultrasound-Assisted Catheter-Directed Thrombolysis in High-Risk and Intermediate-High-Risk Pulmonary Embolism: Results From a Single-Center Cohort. Angiology
Klok FA, Hösel V, Clemens A, Yollo WD, Tilke C, Schulman S, Lankeit M, Konstantinides SV (2016) Prediction of bleeding events in patients with venous thromboembolism on stable anticoagulation treatment. The European respiratory journal
Konstantinides SV, Barco S, Rosenkranz S, Lankeit M, Held M, Gerhardt F, Bruch L, Ewert R, Faehling M, Freise J, Ghofrani HA, Grünig E, Halank M, Heydenreich N, Hoeper MM, Leuchte HH, Mayer E, Meyer FJ, Neurohr C, Opitz C et al. (2016) Late outcomes after acute pulmonary embolism: rationale and design of FOCUS, a prospective observational multicenter cohort study. Journal of thrombosis and thrombolysis
Brandt M, Garlapati V, Oelze M, Sotiriou E, Knorr M, Kröller-Schön S, Kossmann S, Schönfelder T, Morawietz H, Schulz E, Schultheiss HP, Daiber A, Münzel T, Wenzel P (2016) NOX2 amplifies acetaldehyde-mediated cardiomyocyte mitochondrial dysfunction in alcoholic cardiomyopathy. Scientific reports 6: 32554
Karbach SH, Schönfelder T, Brandao I, Wilms E, Hörmann N, Jäckel S, Schüler R, Finger S, Knorr M, Lagrange J, Brandt M, Waisman A, Kossmann S, Schäfer K, Münzel T, Reinhardt C, Wenzel P (2016) Gut Microbiota Promote Angiotensin II-Induced Arterial Hypertension and Vascular Dysfunction. Journal of the American Heart Association 5
Steven S, Jurk K, Kopp M, Kröller-Schön S, Mikhed Y, Schwierczek K, Roohani S, Kashani F, Oelze M, Klein T, Tokalov S, Danckwardt S, Strand S, Wenzel P, Münzel T, Daiber A (2016) Glucagon-like peptide-1 receptor signalling reduces microvascular thrombosis, nitro-oxidative stress and platelet activation in endotoxaemic mice. British journal of pharmacology
Barco S, Lankeit M, Binder H, Schellong S, Christ M, Beyer-Westendorf J, Duerschmied D, Bauersachs R, Empen K, Held M, Schwaiblmair M, Fonseca C, Jimenez D, Becattini C, Quitzau K, Konstantinides S. Home treatment of patients with low-risk pulmonary embolism with the oral factor Xa inhibitor rivaroxaban. Rationale and design of the HoT-PE Trial. Thrombosis and haemostasis 116. 2016.
Ramuschkat M, Appelbaum S, Atzler D, Zeller T, Bauer C, Ojeda FM, Sinning CR, Hoffmann B, Lackner KJ, Boger RH, Wild PS, Münzel T, Blankenberg S, Schwedhelm E, Schnabel RB, Gutenberg Health Study I. ADMA, subclinical changes and atrial fibrillation in the general population. International journal of cardiology 203:640-646. 2016.
Teumer A, Tin A, Sorice R, […], Wild PS, […], Fox CS, Pattaro C, Kottgen A. Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes. Diabetes 65:803-817. 2016.
Baum C, Johannsen SS, Zeller T, Atzler D, Ojeda FM, Wild PS, Sinning CR, Lackner KJ, Gori T, Schwedhelm E, Boger RH, Blankenberg S, Münzel T, Schnabel RB, Gutenberg Health Study i. ADMA and arginine derivatives in relation to non-invasive vascular function in the general population. Atherosclerosis 244:149-156. 2016.
Pattaro C, Teumer A, Gorski M, […], Wild PS, […], Kottgen A, Kao WH, Fox CS. Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nature communications 7:10023. 2016.
de Vries PS, Chasman DI, Sabater-Lleal M, Chen MH, Huffman JE, Steri M, Tang W, Teumer A, Marioni RE, Grossmann V, […], Smith NL, Strachan DP, Dehghan A. A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration. Human molecular genetics 25:358-370. 2016.
Xia N, Horke S, Habermeier A, Closs EI, Reifenberg G, Gericke A, Mikhed Y, Münzel T, Daiber A, Förstermann U, Li H. Uncoupling of Endothelial Nitric Oxide Synthase in Perivascular Adipose Tissue of Diet-Induced Obese Mice. Arteriosclerosis, thrombosis, and vascular biology 36:78-85. 2016.
Koc M, Kostrubiec M, Elikowski W, Meneveau N, Lankeit M, Grifoni S, Kuch-Wocial A, Petris A, Zaborska B, Stefanovic BS, Hugues T, Torbicki A, Konstantinides S, Pruszczyk P, Ri HI. Outcome of patients with right heart thrombi: the Right Heart Thrombi European Registry. The European respiratory journal 47:869-875. 2016.
Hobohm L, Hellenkamp K, Hasenfuss G, Münzel T, Konstantinides S, Lankeit M. Comparison of risk assessment strategies for not-high-risk pulmonary embolism. The European respiratory journal 47:1170-1178. 2016.
Jimenez D, Lobo JL, Fernandez-Golfin C, Portillo AK, Nieto R, Lankeit M, Konstantinides S, Prandoni P, Muriel A, Yusen RD, investigators P. Effectiveness of prognosticating pulmonary embolism using the ESC algorithm and the Bova score. Thrombosis and haemostasis 115:827-834. 2016.
Manukyan D, Müller-Calleja N, Jäckel S, Luchmann K, Monnikes R, Kiouptsi K, Reinhardt C, Jurk K, Walter U, Lackner KJ. Cofactor-independent human antiphospholipid antibodies induce venous thrombosis in mice. Journal of thrombosis and haemostasis 14:1011-1020. 2016.
von Krogh AS, Quist-Paulsen P, Waage A, Langseth OO, Thorstensen K, Brudevold R, Tjonnfjord GE, Largiader CR, Lämmle B, Kremer Hovinga JA. High prevalence of hereditary thrombotic thrombocytopenic purpura in central Norway: from clinical observation to evidence. Journal of thrombosis and haemostasis 14:73-82. 2016.
Segna D, Mean M, Limacher A, Baumgartner C, Blum MR, Beer JH, Kucher N, Righini M, Matter CM, Frauchiger B, Cornuz J, Aschwanden M, Banyai M, Osterwalder J, Husmann M, Egloff M, Staub D, Lämmle B, Angelillo-Scherrer A, Aujesky D, Rodondi N. Association between thyroid dysfunction and venous thromboembolism in the elderly: a prospective cohort study. Journal of thrombosis and haemostasis. 14: 685-94. 2016.
Insam C, Mean M, Limacher A, Angelillo-Scherrer A, Aschwanden M, Banyai M, Beer JH, Bounameaux H, Egloff M, Frauchiger B, Husmann M, Kucher N, Lämmle B, Matter C, Osterwalder J, Righini M, Staub D, Rodondi N, Aujesky D. Anticoagulation Management Practices and Outcomes in Elderly Patients with Acute Venous Thromboembolism: A Clinical Research Study. PloS one 11:e0148348. 2016.
Fan X, Kremer Hovinga JA, Shirotani-Ikejima H, Eura Y, Hirai H, Honda S, Kokame K, Taleghani MM, von Krogh AS, Yoshida Y, Fujimura Y, Lämmle B, Miyata T. Genetic variations in complement factors in patients with congenital thrombotic thrombocytopenic purpura with renal insufficiency. International journal of hematology 103:283-291. 2016.

Reviews 2016

Kiouptsi K, Reinhardt C (2016) Protein disulfide-isomerase - a trigger of tissue factor-dependent thrombosis. Clin Hemorheol Microcirc 64: 279-286
Barco S (2016) Edoxaban for pulmonary embolism with right ventricular dysfunction. Lancet Haematol 3: e405-6
Barco S, Serlie MJ, Coppens M (2016) Primary thromboprophylaxis for adult patients on home parenteral nutrition: A comment on the 2016 ESPEN guideline. Clin Nutr 35: 1579-1580
Mahan CE, Barco S, Spyropoulos AC (2016) Cost-of-illness model for venous thromboembolism. Thrombosis research 145: 130-2
Bochenek ML, Schutz E, Schäfer K (2016) Endothelial cell senescence and thrombosis: Ageing clots. Thrombosis research 147: 36-45
Daiber A, Steven S, Weber A, Shuvaev VV, Muzykantov VR, Laher I, Li H, Lamas S, Münzel T (2016) Targeting vascular (endothelial) dysfunction. British journal of pharmacology
Garn H, Bahn S, Baune BT, Binder EB, Bisgaard H, Chatila TA, Chavakis T, Culmsee C, Dannlowski U, Gay S, Gern J, Haahtela T, Kircher T, Müller-Ladner U, Neurath MF, Preissner KT, Reinhardt C, Rook G, Russell S, Schmeck B et al. (2016) Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation. J Allergy Clin Immunol 138: 47-56
Harjola VP, Mebazaa A, Celutkiene J, Bettex D, Bueno H, Chioncel O, Crespo-Leiro MG, Falk V, Filippatos G, Gibbs S, Leite-Moreira A, Lassus J, Masip J, Mueller C, Mullens W, Naeije R, Nordegraaf AV, Parissis J, Riley JP, Ristic A et al. (2016) Contemporary management of acute right ventricular failure: a statement from the Heart Failure Association and the Working Group on Pulmonary Circulation and Right Ventricular Function of the European Society of Cardiology. European journal of heart failure 18: 226-41
Konstantinides SV (2016) Trends in pregnancy outcomes in patients with pulmonary hypertension: still a long way to go. European journal of heart failure 18: 1129-31
Sista AK, Goldhaber SZ, Vedantham S, Kline JA, Kuo WT, Kahn SR, Kabrhel C, McLaughlin VV, White SB, Kim NH, Gray M, Simon MA, Benenati JF, Misra S, Sterling KM, Kee ST, Konstantinides SV, Jaff MR, Kearon C (2016) Research Priorities in Submassive Pulmonary Embolism: Proceedings from a Multidisciplinary Research Consensus Panel. Journal of vascular and interventional radiology : JVIR 27: 787-94
Ogorodnikov, A., Y. Kargapolova and S. Danckwardt (2016). Processing and transcriptome expansion at the mRNA 3' end in health and disease: finding the right end. Pflugers Arch 468(6): 993-1012.
Ruf, W. (2016). Hemostasis keeps the stem cell niche in order. Blood 128(8): 1027-1029.
Ruf W, Rothmeier AS, Graf C. Targeting clotting proteins in cancer therapy - progress and challenges. Thrombosis research 140 Suppl 1:S1-7. 2016.
Ward PA, Fattahi F, Bosmann M. New Insights into Molecular Mechanisms of Immune Complex-Induced Injury in Lung. Frontiers in immunology 7:86. 2016.
Krenzlin H, Lorenz V, Danckwardt S, Kempski O, Alessandri B. The Importance of Thrombin in Cerebral Injury and Disease. International journal of molecular sciences 17. 2016.
Gur-Cohen S, Kollet O, Graf C, Esmon CT, Ruf W, Lapidot T. Regulation of long-term repopulating hematopoietic stem cells by EPCR/PAR1 signaling. Annals of the New York Academy of Sciences. 2016.
Konstantinides SV, Barco S, Lankeit M, Meyer G. Management of Pulmonary Embolism: An Update. Journal of the American College of Cardiology 67:976-990. 2016.
Lankeit M, Held M. Incidence of venous thromboembolism in COPD: linking inflammation and thrombosis? The European respiratory journal 47:369-373. 2016.
Lämmle B. Thrombotic microangiopathy: Caplacizumab accelerates resolution of acute acquired TTP. Nature reviews. Nephrology 12:259-260. 2016.

Editorials und Fachbeiträge 2016

Konstantinides SV. Trends in incidence versus case fatality rates of pulmonary embolism: Good news or bad news? Thrombosis and haemostasis 115:233-235. 2016.
Konstantinides SV. Trends in Pulmonary Embolism Outcomes: Are We Really Making Progress? Journal of the American College of Cardiology 67:171-173. 2016.

Isth Steering Committee for World Thrombosis Day (2016) Venous thromboembolism: A Call for risk assessment in all hospitalised patients. Thrombosis and haemostasis 116: 777-779
Wilkens H, Konstantinides S, Lang I, Bunck AC, Gerges M, Gerhardt F, Grgic A, Grohe C, Guth S, Held M, Hinrichs J, Hoeper MM, Klepetko W, Kramm T, Kruger U, Lankeit M, Meyer BC, Olsson KM, Schafers HJ, Schmidt M et al. (2016) [Chronic thromboembolic pulmonary hypertension: Recommendations of the Cologne Consensus Conference 2016]. Deutsche medizinische Wochenschrift 141: S62-S69
Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, Falk V, Gonzalez-Juanatey JR, Harjola VP, Jankowska EA, Jessup M, Linde C, Nihoyannopoulos P, Parissis JT, Pieske B, Riley JP, Rosano GM, Ruilope LM, Ruschitzka F, Rutten FH et al. (2016) 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC)Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. European heart journal

Originalartikel 2015

Atzler D, Appelbaum S, Cordts K, Ojeda FM, Wild PS, Münzel T, Blankenberg S, Boger RH, Blettner M, Beutel ME, Pfeiffer N, Zeller T, Lackner KJ, Schwedhelm E. Reference intervals of plasma homoarginine from the German Gutenberg Health Study. Clinical chemistry and laboratory medicine. 2015.
Pfützner A, Hermanns I, Ramljak S, Demircik F, Pfützner AH, Kann PH, Weber MM. Elevated Intact Proinsulin Levels During an Oral Glucose Challenge Indicate Progressive ss-Cell Dysfunction and May Be Predictive for Development of Type 2 Diabetes. Journal of diabetes science and technology 9:1307-1312. 2015.
Hauser F, Rossmann H, Laubert-Reh D, Wild PS, Zeller T, Müller C, Neuwirth S, Blankenberg S, Lackner KJ. Inflammatory bowel disease (IBD) locus 12: is glutathione peroxidase-1 (GPX1) the relevant gene? Genes and immunity 16:571-575. 2015.
Zeller T, Haase T, Müller C, Riess H, Lau D, Zeller S, Krause J, Baumert J, Pless O, Dupuis J, Wild PS, Eleftheriadis M, Waldenberger M, Zeilinger S, Ziegler A, Peters A, Tiret L, Proust C, Marzi C, Münzel T, Strauch K, Prokisch H, Lackner KJ, Herder C, Thorand B, Benjamin EJ, Blankenberg S, Koenig W, Schnabel RB. Molecular Characterization of the NLRC4 Expression in Relation to Interleukin-18 Levels. Circulation. Cardiovascular genetics 8:717-726. 2015.
Homuth G, Wahl S, Muller C, [...], Wild PS, Ziegler A, Volker U, Prokisch H, Zeller T. Extensive alterations of the whole-blood transcriptome are associated with body mass index: results of an mRNA profiling study involving two large population-based cohorts. BMC medical genomics 8:65. 2015.
Hasibeder A, Stein P, Brandwijk R, Schild H, Radsak MP. Evaluation and Validation of the Detection of soluble Triggering Receptor Expressed on Myeloid Cells 1 by Enzyme-linked immunosorbent Assay. Scientific reports 5:15381. 2015.
Liang HP, Kerschen EJ, Basu S, Hernandez I, Zogg M, Jia S, Hessner MJ, Toso R, Rezaie AR, Fernandez JA, Camire RM, Ruf W, Griffin JH, Weiler H. Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice. Blood 126:2415-2423. 2015.
Schnabel RB, Wild PS, Prochaska JH, Ojeda FM, Zeller T, Rzayeva N, Ebrahim A, Lackner KJ, Beutel ME, Pfeiffer N, Sinning CR, Oertelt-Prigione S, Regitz-Zagrosek V, Binder H, Münzel T, Blankenberg S, Gutenberg Health Study I. Sex Differences in Correlates of Intermediate Phenotypes and Prevalent Cardiovascular Disease in the General Population. Frontiers in cardiovascular medicine 2:15. 2015.
Cohen SG, Itkin T, Chakrabarty S, Graf C, Kollet O, Ludin A, Golan K, Kalinkovich A, Ledergor G, Wong E, Niemeyer E, Porat Z, Erez A, Sagi I, Esmon CT, Ruf W, Lapidot T. PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells. Nature medicine. 21:1307-1317. 2015.
Hellenkamp K, Schwung J, Rossmann H, Kaeberich A, Wachter R, Hasenfuss G, Konstantinides S, Lankeit M. Risk stratification of normotensive pulmonary embolism: prognostic impact of copeptin. The European respiratory journal. 2015.
Klok FA, Dzikowska-Diduch O, Kostrubiec M, Vliegen HW, Pruszczyk P, Hasenfuss G, Huisman MV, Konstantinides S, Lankeit M. Derivation of a clinical prediction score for chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. Journal of thrombosis and haemostasis : JTH. 2015.
Ponto KA, Binder H, Diana T, Matheis N, Otto AF, Pitz S, Pfeiffer N, Kahaly GJ. Prevalence, Phenotype, and Psychosocial Well-Being in Euthyroid/Hypothyroid Thyroid-Associated Orbitopathy. Thyroid. 25:942-948. 2015.
Keller K, Prochaska JH, Coldewey M, Gobel S, Ullmann A, Jünger C, Lamparter H, Ariza L, Bickel C, Lauterbach M, Konstantinides S, Rostock T, Münzel T, Wild PS. History of deep vein thrombosis is a discriminator for concomitant atrial fibrillation in pulmonary embolism. Thrombosis research 136:899-906. 2015.
Panova-Noeva M, Schulz A, Hermanns I, Grossmann V, Pefani E, Spronk H, Laubert-Reh D, Binder H, Beutel M, Pfeiffer N, Blankenberg S, Zeller T, Münzel T, Lackner KJ, Ten Cate H, Wild PS. Sex specific differences in genetic and non-genetic determinants of mean platelet volume: results from the Gutenberg Health Study. Blood. 2015.
Larmann J, Jurk K, Janssen H, Müller M, Herzog C, Lorenz A, Schmitz M, Nofer JR, Theilmeier G. Hepatic Overexpression of Soluble Urokinase Receptor (uPAR) Suppresses Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient (LDLR-/-) Mice. PloS one 10:e0131854. 2015.
Wenzel P, Rossmann H, Müller C, Kossmann S, Oelze M, Schulz A, Arnold N, Simsek C, Lagrange J, Klemz R, Schönfelder T, Brandt M, Karbach SH, Knorr M, Finger S, Neukirch C, Häuser F, Beutel ME, Kröller-Schön S, Schulz E, Schnabel RB, Lackner K, Wild PS, Zeller T, Daiber A, Blankenberg S, Münzel T. Heme oxygenase-1 suppresses a pro-inflammatory phenotype in monocytes and determines endothelial function and arterial hypertension in mice and humans. European heart journal. 2015.
Reiss C, Mindukshev I, Bischoff V, Subramanian H, Kehrer L, Friebe A, Stasch JP, Gambaryan S, Walter U. The sGC stimulator Riociguat inhibits platelet function in washed platelets but not in whole blood. British journal of pharmacology, 2015.
Larmann J, Jurk K, Janssen H, Müller M, Herzog C, Lorenz A, Schmitz M, Nofer JR, Theilmeier G. Hepatic Overexpression of Soluble Urokinase Receptor (uPAR) Suppresses Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient (LDLR-/-) Mice. PloS one. 10:e0131854, 2015.
Jacobsen C, Oechsle K, Hauschild J, Steinemann G, Spath B, Bokemeyer C, Ruf W, Honecker F, Langer F. Regulation of tissue factor in NT2 germ cell tumor cells by cisplatin chemotherapy. Thrombosis research, 2015.
Reiss C, Mindukshev I, Bischoff V, Subramanian H, Kehrer L, Friebe A, Stasch JP, Gambaryan S, Walter U. The sGC stimulator Riociguat inhibits platelet function in washed platelets but not in whole blood. British journal of pharmacology, 2015.
Höhn R, Kottler U, Peto T, Blettner M, Münzel T, Blankenberg S, Lackner KJ, Beutel M, Wild PS, Pfeiffer N. The ophthalmic branch of the Gutenberg Health Study: study design, cohort profile and self-reported diseases. PloS one. 10:e0120476, 2015.
Elflein HM, Fresenius S, Lamparter J, Pitz S, Pfeiffer N, Binder H, Wild P, Mirshahi A. The prevalence of amblyopia in Germany: data from the prospective, population-based Gutenberg Health Study. Deutsches Ärzteblatt international 112:338-344, 2015.
Ding J, Reynolds LM, Zeller T, Müller C, Mstat KL, Nicklas BJ, Kritchevsky SB, Huang Z, Fuente A, Soranzo N, Settlage RE, Chuang CC, Howard T, Xu N, Goodarzi MO, Ida Chen YD, Rotter JI, Siscovick DS, Parks JS, Murphy S, Jacobs DR, Jr., Post W, Tracy RP, Wild PS, Blankenberg S, Hoeschele I, Herrington D, McCall CE, Liu Y. Alterations of a cellular cholesterol metabolism network is a molecular feature of obesity-related type 2 diabetes and cardiovascular disease. Diabetes, 2015.
Wendelboe AM, McCumber M, Hylek EM, Buller H, Weitz JI, Raskob G, Day ISCfWT. 2015. Global public awareness of venous thromboembolism. Journal of thrombosis and haemostasis : JTH 13:1365-1371, 2015.
Gori T, Wild PS, Schnabel R, Schulz A, Pfeiffer N, Blettner M, Beutel ME, Forconi S, Jung F, Lackner KJ, Blankenberg S, Münzel T. The distribution of whole blood viscosity, its determinants and relationship with arterial blood pressure in the community: cross-sectional analysis from the Gutenberg Health Study. Therapeutic advances in cardiovascular disease, 2015.
Demircik F, Ramljak S, Hermanns I, Pfützner A, Pfützner A. Evaluation of hematocrit interference with MyStar extra and seven competitive devices. Journal of diabetes science and technology. 9:262-267, 2015.
Jabs A, Oelze M, Mikhed Y, Stamm P, Kröller-Schön S, Welschof P, Jansen T, Hausding M, Kopp M, Steven S, Schulz E, Stasch JP, Münzel T, Daiber A. Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats. Vascular pharmacology, 2015.
Steven S, Hausding M, Kröller-Schön S, Mader M, Mikhed Y, Stamm P, Zinssius E, Pfeffer A, Welschof P, Agdauletova S, Sudowe S, Li H, Oelze M, Schulz E, Klein T, Münzel T, Daiber A. Gliptin and GLP-1 analog treatment improves survival and vascular inflammation/dysfunction in animals with lipopolysaccharide-induced endotoxemia. Basic research in cardiology. 110:6, 2015.
Horke S, Xiao J, Schutz EM, Kramer GL, Wilgenbus P, Witte I, Selbach M, Teiber JF. A novel paraoxonase 2-dependent mechanism mediating the biological effects of the Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxo-dodecanoyl)-L-homoserine lactone. Infection and immunity, 2015.
Hermanns MI, Grossmann V, Spronk HM, Schulz A, Junger C, Laubert-Reh D, Mazur J, Gori T, Zeller T, Pfeiffer N, Beutel M, Blankenberg S, Münzel T, Lackner KJ, Ten Cate-Hoek AJ, Ten Cate H, Wild PS. Distribution, genetic and cardiovascular determinants of FVIII:c - Data from the population-based Gutenberg Health Study. International journal of cardiology. 187:166-174, 2015.
Krüger M, Pabst AM, Al-Nawas B, Horke S, Moergel M. Paraoxonase-2 (PON2) protects oral squamous cell cancer cells against irradiation-induced apoptosis. Journal of cancer research and clinical oncology, 2015.
Hinkel R, Lange P, Petersen B, Gottlieb E, Ng JK, Finger S, Horstkotte J, Lee S, Thormann M, Knorr M, El-Aouni C, Boekstegers P, Reichart B, Wenzel P, Niemann H, Kupatt C. Heme Oxygenase-1 Gene Therapy Provides Cardioprotection Via Control of Post-Ischemic Inflammation: An Experimental Study in a Pre-Clinical Pig Model. Journal of the American College of Cardiology. 66:154-165, 2015.
von Krogh AS, Kremer Hovinga JA, Romundstad PR, Roten LT, Lämmle B, Waage A, Quist-Paulsen P. ADAMTS13 gene variants and function in women with preeclampsia: A population- based nested case- control study from the HUNT Study. Thrombosis research, 14: 73-82. 2015.
Raum P, Lamparter J, Ponto KA, Peto T, Hoehn R, Schulz A, Schneider A, Wild PS, Pfeiffer N, Mirshahi A. Prevalence and Cardiovascular Associations of Diabetic Retinopathy and Maculopathy: Results from the Gutenberg Health Study. PloS one. 10:e0127188, 2015.
- Correction
Gogiraju R, Xu X, Bochenek ML, Steinbrecher JH, Lehnart SE, Wenzel P, Kessel M, Zeisberg EM, Dobbelstein M, Schäfer K. Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice. Journal of the American Heart Association 4, 2015.
Frank B, Ariza L, Lamparter H, Grossmann V, Prochaska JH, Ullmann A, Kindler F, Weisser G, Walter U, Lackner KJ, Espinola-Klein C, Munzel T, Konstantinides SV, Wild PS, group VTs. Rationale and design of three observational, prospective cohort studies including biobanking to evaluate and improve diagnostics, management strategies and risk stratification in venous thromboembolism: the VTEval Project. BMJ open 5:e008157, 2015.
Klok FA, Niemann C, Dellas C, Hasenfuss G, Konstantinides S, Lankeit M. Performance of five different bleeding-prediction scores in patients with acute pulmonary embolism. Journal of thrombosis and thrombolysis, 2015.
Stakos DA, Kambas K, Konstantinidis T, Mitroulis I, Apostolidou E, Arelaki S, Tsironidou V, Giatromanolaki A, Skendros P, Konstantinides S, Ritis K. Expression of functional tissue factor by neutrophil extracellular traps in culprit artery of acute myocardial infarction. European heart journal 36:1405-1414, 2015.
Ponto KA, Elbaz H, Peto T, Laubert-Reh D, Binder H, Wild PS, Lackner K, Pfeiffer N, Mirshahi A. Prevalence and risk factors of retinal vein occlusion: the Gutenberg Health Study. J Thromb Haemost. 13:1254-1263, 2015.
Grossmann V, Schmitt VH, Zeller T, Panova-Noeva M, Schulz A, Laubert-Reh D, Juenger C, Schnabel RB, Abt TG, Laskowski R, Wiltink J, Schulz E, Blankenberg S, Lackner KJ, Münzel T, Wild PS. Profile of the Immune and Inflammatory Response in Individuals With Prediabetes and Type 2 Diabetes. Diabetis care. pii: dc143008, 2015.
Russkamp NF, Ruemmler R, Roewe J, Moore BB, Ward PA, Bosmann M. Experimental design of complement component 5a-induced acute lung injury (C5a-ALI): a role of CC-chemokine receptor type 5 during immune activation by anaphylatoxin. FASEB journal pii: fj.15-271635, 2015.
Bollmann F*, Jäckel S*, Schmidtke L, Schrick K, Reinhardt C, Jurk K, Wu Z, Xia N, Li H, Erkel G, Walter U, Kleinert H**, Pautz A**. Anti-Inflammatory and Anti-Thrombotic Effects of the Fungal Metabolite Galiellalactone in Apolipoprotein E-Deficient Mice. PloS one. 10:e0130401, 2015.
Müller-Calleja N, Kohler A, Siebald B, Canisius A, Orning C, Radsak M, Stein P, Monnikes R, Lackner KJ. Cofactor-independent antiphospholipid antibodies activate the NLRP3-inflammasome via endosomal NADPH-oxidase: implications for the antiphospholipid syndrome. Thrombosis and haemostasis 113, 2015.
Michal M, Prochaska JH, Keller K, Göbel S, Coldewey M, Ullmann A, Schulz A, Lamparter H, Münzel T, Reiner I, Beutel ME, Wild PS. Symptoms of depression and anxiety predict mortality in patients undergoing oral anticoagulation: Results from the thrombEVAL study program. International journal of cardiology 187:614-619, 2015.
Zolfaghari S, Harenberg J, Frölich L, Weiss C, Wehling M, Wild P, Prochaska J, Beyer-Westendorf J, Koscielny J, Lip GY. Development of recommendations to continue anticoagulation with one of the two types of oral anticoagulants based on the identification of patients' preference. Seminars in thrombosis and hemostasis 41:166-177, 2015.
Wu Z, Siuda D, Xia N, Reifenberg G, Daiber A, Münzel T, Förstermann U, Li H. Maternal treatment of spontaneously hypertensive rats with pentaerythritol tetranitrate reduces blood pressure in female offspring. Hypertension. 65:232-237, 2015.
DZHK-Paper of the month: Januar 2015
DZHK Pressemitteilung
Taddonio MA, Dolgachev V, Bosmann M, Ward PA, Su G, Wang SC, Hemmila MR. Influence of Lipopolysaccharide Binding Protein on Pulmonary Inflammation in Gram-negative Pneumonia. Shock. 2015.
Kalbitz M, Grailer JJ, Fattahi F, Jajou L, Herron TJ, Campbell KF, Zetoune FS, Bosmann M, Sarma JV, Huber-Lang M, Gebhard F, Loaiza R, Valdivia HH, Jalife J, Russell MW, Ward PA. Role of extracellular histones in the cardiomyopathy of sepsis. FASEB journal. pii: fj.14-268730, 2015.
Henninger C, Huelsenbeck S, Wenzel P, Brand M, Huelsenbeck J, Schad A, Fritz G. Chronic heart damage following doxorubicin treatment is alleviated by lovastatin. Pharmacological research. 91:47-56, 2015.
Prochaska JH, Gobel S, Keller K, Coldewey M, Ullmann A, Lamparter H, Junger C, Al-Bayati Z, Baer C, Walter U, Bickel C, Ten Cate H, Munzel T, Wild PS. Quality of oral anticoagulation with phenprocoumon in regular medical care and its potential for improvement in a telemedicine-based coagulation service inverted question mark results from the prospective, multi-center, observational cohort study thrombEVAL. BMC medicine. 13:14, 2015.
Kaeberich A, Seeber V, Jimenez D, Kostrubiec M, Dellas C, Hasenfuss G, Giannitsis E, Pruszczyk P, Konstantinides S, Lankeit M. Age-adjusted hsTnT cut-off value for risk stratification of pulmonary embolism. The European respiratory journal. 2015.
Kurmann R, Weisstanner C, Kardas P, Hirsch HH, Wiest R, Lämmle B, Furrer H, Du Pasquier R, Bassetti CL, Sturzenegger M, Krestel H. Progressive multifocal leukoencephalopathy in common variable immunodeficiency: mitigated course under mirtazapine and mefloquine. Journal of neurovirology, 21: 694-701. 2015.
von Känel R, Margani A, Stauber S, Meyer FA, Demarmels Biasiutti F, Vökt F, Wissmann T, Lämmle B, Lukas PS. Depressive symptoms as a novel risk factor for recurrent venous thromboembolism: a longitudinal observational study in patients referred for thrombophilia investigation. PloS one 10:e0125858, 2015.
Brandao I, Hörmann N, Jäckel S, Reinhardt C. TLR5 expression in the small intestine depends on the adaptors MyD88 and TRIF, but is independent of the enteric microbiota. Gut microbes:1-5, 2015.
Schnabel RB, Johannsen SS, Wild PS, Blankenberg S. [Prevalence and risk factors of atrial fibrillation in Germany : data from the Gutenberg Health Study]. Herz 40:8-15, 2015.
Rothmeier AS, Marchese P, Petrich BG, Furlan-Freguia C, Ginsberg MH, Ruggeri ZM, Ruf W. Caspase-1-mediated pathway promotes generation of thromboinflammatory microparticles. The Journal of clinical investigation. 125:1471-1484, 2015.
Klok FA, Tesche C, Rappold L, Dellas C, Hasenfuss G, Huisman MV, Konstantinides S, Lankeit M. External validation of a simple non-invasive algorithm to rule out chronic thromboembolic pulmonary hypertension after acute pulmonary embolism. Thrombosis research 135:796-801, 2015.
Keller K, Beule J, Balzer JO, Dippold W. Modified Bova score for risk stratification and short-term outcome in acute pulmonary embolism. The Netherlands journal of medicine 73:410-416. 2015.
Keller K, Beule J, Balzer JO, Dippold W. Blood pressure for outcome prediction and risk stratification in acute pulmonary embolism. The American journal of emergency medicine 33:1617-1621. 2015.
Keller K, Beule J, Coldewey M, Geyer M, Balzer JO, Dippold W. The risk factor age in normotensive patients with pulmonary embolism: Effectiveness of age in predicting submassive pulmonary embolism, cardiac injury, right ventricular dysfunction and elevated systolic pulmonary artery pressure in normotensive pulmonary embolism patients. Experimental gerontology 69:116-121. 2015.
Keller K, Beule J, Balzer JO, Dippold W. Typical symptoms for prediction of outcome and risk stratification in acute pulmonary embolism. International angiology. 2015.
Keller K, Beule J, Schulz A, Coldewey M, Dippold W, Balzer JO. D-dimer for risk stratification in haemodynamically stable patients with acute pulmonary embolism. Advances in medical sciences 60:204-210. 2015.
Keller K, Beule J, Coldewey M, Dippold W, Balzer JO. Heart rate in pulmonary embolism. Internal and emergency medicine 10:663-669. 2015.
Keller K, Geyer M, Beule J, Coldewey M, Balzer JO, Dippold W. Impact of cancer on the effectiveness of cardiac Troponin I to predict right ventricular dysfunction in acute pulmonary embolism. Thoracic cancer 6:584-588. 2015.
Keller K, Beule J, Coldewey M, Dippold W, Balzer JO. Impact of advanced age on the severity of normotensive pulmonary embolism. Heart and vessels 30:647-656. 2015.
Keller K, Beule J, Schulz A, Coldewey M, Dippold W, Balzer JO. Cardiac troponin I for predicting right ventricular dysfunction and intermediate risk in patients with normotensive pulmonary embolism. Netherlands heart journal 23:55-61. 2015.

Reviews 2015

Hahn SA, Bellinghausen I, Trinschek B, Becker C. Translating Treg Therapy in Humanized Mice. Frontiers in immunology 6:623. 2015.
Daiber A, Di Lisa F, Oelze M, Kröller-Schön S, Steven S, Schulz E, Münzel T. Crosstalk of mitochondria with NADPH oxidase via reactive oxygen and nitrogen species signalling and its role for vascular function. British journal of pharmacology. 2015.
van der Meijden PE, Ozaki Y, Ruf W, de Laat B, Mutch N, Diamond S, Nieuwland R, Peters TC, Heestermans M, Kremers RM, Moorlag M, Boender J, Unlu B, Reitsma PH. Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome). Thrombosis research. 136 Suppl 1:S3-7. 2015.
Comerota AJ, Sandset PM, Konstantinides S, de Graaf R, Wakefield TW, Arnoldussen CW, Lam YL, van Gent WB, de Wolf MA, Catarinella FS, Kurstjens RL, Alshabatat A, Wittens CH. Theme 4: Invasive management of (recurrent) VTE and PTS. Thrombosis research 136 Suppl 1:S19-25. 2015.
Konstantinides S. [Coronary heart disease: Genetic score identifies risk patients]. Deutsche medizinische Wochenschrift 140:1418.
Hellenkamp K, Schwung J, Rossmann H, Kaeberich A, Wachter R, Hasenfuss G, Konstantinides S, Lankeit M. Risk stratification of normotensive pulmonary embolism: prognostic impact of copeptin. The European respiratory journal. 2015.
Grove EL, Lankeit M, Hess K, Freynhofer M, Stojkovic S, Varenhorst C, Thomas M. CardioPulse: the 'Young Thrombosis Researchers Group' of the ESC Working Group on Thrombosis. European heart journal. 36:703-704, 2015.
Steven S, Münzel T, Daiber A. Exploiting the Pleiotropic Antioxidant Effects of Established Drugs in Cardiovascular Disease. International journal of molecular sciences. 16:18185-18223, 2015.
Ruf W. Diverse packaging of TF into platelets. Thrombosis and haemostasis. 114, 2015.
Mikhed Y, Daiber A, Steven S. Mitochondrial Oxidative Stress, Mitochondrial DNA Damage and Their Role in Age-Related Vascular Dysfunction. International journal of molecular sciences. 16:15918-15953, 2015.
Wärntges S, Konstantinides SV. Progress in the management of acute pulmonary embolism. Current opinion in pulmonary medicine, 2015.
Klok FA, Meyer G, Konstantinides S. Management of intermediate-risk pulmonary embolism: uncertainties and challenges. http://www.ncbi.nlm.nih.gov/pubmed/26109174European journal of haematology, 2015.
Konstantinides SV, Wärntges S. Acute phase treatment of venous thromboembolism: advanced therapy. Systemic fibrinolysis and pharmacomechanical therapy. Thrombosis and haemostasis 113, 2015.
Ruf W, Samad F. Tissue factor pathways linking obesity and inflammation. Hamostaseologie 35, 2015.
Klok FA, Kooiman J, Huisman MV, Konstantinides S, Lankeit M. Predicting anticoagulant-related bleeding in patients with venous thromboembolism: a clinically oriented review. The European respiratory journal. 45:201-210, 2015.
Lämmle B. VWF and complement. Blood. 125:896-898, 2015.
von Auer C, von Krogh AS, Kremer Hovinga JA, Lämmle B. Current insights into thrombotic microangiopathies: Thrombotic thrombocytopenic purpura and pregnancy. Thrombosis research 135 Suppl 1:S30-33, 2015.
Kruger P, Saffarzadeh M, Weber AN, Rieber N, Radsak M, von Bernuth H, Benarafa C, Roos D, Skokowa J, Hartl D. Neutrophils: Between host defence, immune modulation, and tissue injury. PLoS pathogens 11:e1004651, 2015.
Keller K, Engelhardt M. [Historical Changes in Meniscus Surgery--The Changing Appreciation of Disease, Surgical Techniques and Complications]. Zeitschrift fur Orthopadie und Unfallchirurgie 153:259-266. 2015.

Editorials und Fachbeiträge 2015

Konstantinides SV, Lankeit M, Wild P, Quitzau K, Binder H, im Auftrag der F-I. [Follow-up after acute pulmonary embolism. A prospective non-interventional multi-center cohort study (FOCUS)]. Deutsche medizinische Wochenschrift. 140 Suppl 1:S20-21, 2015.

Originalartikel 2014

Bosmann M, Russkamp NF, Strobl B, Roewe J, Balouzian L, Pache F, Radsak MP, van Rooijen N, Zetoune FS, Sarma JV, Nunez G, Muller M, Murray PJ, Ward PA. Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3. Journal of immunology. 193:5668-5677, 2014.
Oelze M, Kroller-Schon S, Steven S, Lubos E, Doppler C, Hausding M, Tobias S, Brochhausen C, Li H, Torzewski M, Wenzel P, Bachschmid M, Lackner KJ, Schulz E, Munzel T, Daiber A. Glutathione peroxidase-1 deficiency potentiates dysregulatory modifications of endothelial nitric oxide synthase and vascular dysfunction in aging. Hypertension. 63:390-396, 2014.
Zeller T, Ojeda F, Brunner FJ, Peitsmeyer P, Munzel T, Binder H, Pfeiffer N, Michal M, Wild PS, Blankenberg S, Lackner KJ. High-sensitivity cardiac troponin I in the general population - defining reference populations for the determination of the 99th percentile in the Gutenberg Health Study. Clinical chemistry and laboratory medicine. 2014.
Wiltink J, Michal M, Wild PS, Schneider A, Konig J, Blettner M, Munzel T, Schulz A, Weber M, Fottner C, Pfeiffer N, Lackner K, Beutel ME. Associations between depression and diabetes in the community: do symptom dimensions matter? Results from the Gutenberg Health Study. PloS one 9:e105499, 2014.
Schnabel RB, Wild PS, Wilde S, Ojeda FM, Schulz A, Zeller T, Sinning CR, Kunde J, Lackner KJ, Munzel T, Blankenberg S. Multiple biomarkers and atrial fibrillation in the general population. PloS one. 9:e11248, 2014.
Michal M, Wiltink J, Kirschner Y, Schneider A, Wild PS, Munzel T, Blettner M, Schulz A, Lackner K, Pfeiffer N, Blankenberg S, Tschan R, Tuin I, Beutel ME. Complaints of sleep disturbances are associated with cardiovascular disease: results from the Gutenberg Health Study. PloS one. 9:e104324, 2014.
Michal M, Prochaska JH, Ullmann A, Keller K, Gobel S, Coldewey M, Munzel T, Wiltink J, Beutel ME, Wild PS. Relevance of depression for anticoagulation management in a routine medical care setting: Results from the ThrombEVAL study program. Journal of thrombosis and haemostasis. 2014.
Luneburg N, Lieb W, […], Wild PS, […], Vasan RS, Boger RH. Genome-Wide Association Study of L-Arginine and Dimethylarginines Reveals Novel Metabolic Pathway for Symmetric Dimethylarginine. Circulation. Cardiovascular genetics. 2014.
Karbach S, Croxford AL, Oelze M, Schuler R, Minwegen D, Wegner J, Koukes L, Yogev N, Nikolaev A, Reissig S, Ullmann A, Knorr M, Waldner M, Neurath MF, Li H, Wu Z, Brochhausen C, Scheller J, Rose-John S, Piotrowski C, Bechmann I, Radsak M, Wild P, Daiber A, von Stebut E, Wenzel P, Waisman A, Munzel T. Interleukin 17 drives vascular inflammation, endothelial dysfunction, and arterial hypertension in psoriasis-like skin disease. Arteriosclerosis, thrombosis, and vascular biology. 34:2658-2668, 2014.
Engelhardt B, Konig J, Blettner M, Wild P, Munzel T, Lackner K, Blankenberg S, Pfeiffer N, Beutel M, Zwiener I. 2014. Combining cross-sectional data on prevalence with risk estimates from a prediction model. A novel method for estimating the attributable risk. Methods of information in medicine. 53:371-379, 2014.
Beygui F, Wild PS, Zeller T, Germain M, Castagne R, Lackner KJ, Munzel T, Montalescot G, Mitchell GF, Verwoert GC, Tarasov KV, Tregouet DA, Cambien F, Blankenberg S, Tiret L. Adrenomedullin and arterial stiffness: integrative approach combining monocyte ADM expression, plasma MR-Pro-ADM, and genome-wide association study. Circulation. Cardiovascular genetics. 7:634-641, 2014.
Hörmann N, Brandao I, Jäckel S, Ens N, Lillich M, Walter U, Reinhardt C. Gut microbial colonization orchestrates TLR2 expression, signaling and epithelial proliferation in the small intestinal mucosa. PloS one. 9:e113080, 2014.
Kossmann S, Hu H, Steven S, Schönfelder T, Fraccarollo D, Mikhed Y, Brähler M, Knorr M, Brandt M, Karbach SH, Becker C, Oelze M, Bauersachs J, Widder J, Münzel T, Daiber A, Wenzel P. Inflammatory Monocytes Determine Endothelial Nitric Oxide Synthase Uncoupling and Nitro-oxidative Stress Induced by Angiotensin II. Journal of Biological Chemistry. pii: jbc.M114.604231, 2014.
Zeller T, Keller T, Ojeda F, Reichlin T, Twerenbold R, Tzikas S, Wild PS, Reiter M, Czyz E, Lackner KJ, Munzel T, Mueller C, Blankenberg S. Assessment of microRNAs in patients with unstable angina pectoris. European Heart Journal. 35(31):2106-14, 2014.
Weber M, Rudolph B, Stein P, Yogev N, Bosmann M, Schild H, Radsak MP. Host-derived CD8+ dendritic cells protect against acute Graft-versus-Host Disease after experimental allogeneic bone marrow transplantation. Biology of Blood and Marrow Transplantation. pii: S1083-8791(14)00504-7, 2014.
Dorweiler B, Grechowa I, Wallrath A, Vahl CF, Horke S. Activation of the pro-apoptotic unfolded protein response in plaques of the human carotid artery. European Journal of Vascular and Endovascular Surgery. pii: S1078-5884(14)00357-8, 2014.
Ponto KA, Zwiener I, Al-Nawas B, Kahaly GJ, Otto AF, Karbach J. Piezosurgery for Orbital Decompression Surgery in Thyroid Associated Orbitopathy. Journal of Cranio-Maxillofacial Surgery. pii: S1010-5182(14)00204-2, 2014.
Hubertus K, Mischnik M, Timmer J, Herterich S, Mark R, Moulard M, Walter U, Geiger J. Reciprocal regulation of human platelet function by endogenous prostanoids and through multiple prostanoid receptors. European Journal of Pharmacology. 740C:15-27, 2014.
de Witt SM, Swieringa F, Cavill R, ... Jurk K ... Heemskerk JW, Cosemans JM. Identification of platelet function defects by multi-parameter assessment of thrombus formation. Nature Communications. 5:4257, 2014.
Herder C, Nuotio ML, Shah S, Blankenberg S, ..., Wild PS, ... Kumari M, Perola M, Salomaa V. Genetic determinants of circulating interleukin-1 receptor antagonist levels and their association with glycemic traits. Diabetes. pii: DB_140731, 2014.
Knorr M, Hausding M, Pfeffer A, Jurk K, Jansen T, Schwierczek K, Oelze M, Kröller-Schön S, Schulz E, Wenzel P, Gori T, Burgin K, Sartor D, Scherhag A, Münzel T, Daiber A. In vitro and in vivo Characterization of a New Organic Nitrate Hybrid Drug Covalently Bound to Pioglitazone. Pharmacology. 93(5-6):203-215, 2014.
Oelze M, Kröller-Schön S, Steven S, Lubos E, Doppler C, Hausding M, Tobias S, Brochhausen C, Li H, Torzewski M, Wenzel P, Bachschmid M, Lackner KJ, Schulz E, Münzel T, Daiber A. Glutathione peroxidase-1 deficiency potentiates dysregulatory modifications of endothelial nitric oxide synthase and vascular dysfunction in aging. Hypertension. 63(2):390-6, 2014.
Prüfer S, Weber M, Stein P, Bosmann M, Stassen M, Kreft A, Schild H, Radsak MP. Oxidative burst and neutrophil elastase contribute to clearance of Aspergillus fumigatus pneumonia in mice. Immunobiology. 219:87-96, 2014.
Ostad MA, Wild PS, Schnorbus B, Schulz A, Munzel T, Warnholtz A. Predictive value of brachial reactive hyperemia and flow-mediated dilation in stable coronary artery disease. Clinical Hemorheology and Microcirculation. 56(3):247-57, 2014.
Bollmann F, Wu Z, Oelze M, Siuda D, Xia N, Henke J, Daiber A, Li H, Stumpo DJ, Blackshear PJ, Kleinert H, Pautz A. Endothelial Dysfunction in Tristetraprolin-deficient Mice Is Not Caused by Enhanced Tumor Necrosis Factor-α Expression. The Journal of Biological Chemistry. Vol. 289, No. 22, pp. 15653–15665, 2014.
Schnorbus B, Daiber A, Jurk K, Warnke S, König J, Krahn U, Lackner K, Munzel T, Gori T. Effects of clopidogrel, prasugrel and ticagrelor on endothelial function, inflammatory and oxidative stress parameters and platelet function in patients undergoing coronary artery stenting for an acute coronary syndrome. A randomised, prospective, controlled study. BMJ open. 4(5):e005268, 2014.
von Krogh AS, Kremer Hovinga JA, Tjønnfjord GE, Ringen IM, Lämmle B, Waage A, Quist-Paulsen P. The impact of congenital thrombotic thrombocytopenic purpura on pregnancy complications. Thrombosis and Haemostasis. 111(6):1180-3, 2014.
Ponto K, Schuppan D, Zwiener I, Binder H, Mirshahi A, Diana T, Pitz S, Pfeiffer N, Kahaly G. Thyroid-associated orbitopathy is linked to gastrointestinal autoimmunity. Clinical and experimental immunology. 2014.
Beutel ME, Wiltink J, Kirschner Y, Sinning C, Espinola-Klein C, Wild PS, Munzel T, Blettner M, Zwiener I, Lackner K, Michal M. History of depression but not current depression is associated with signs of atherosclerosis: data from the Gutenberg Health Study. Psychological Medicine. 44(5):919-25, 2014.
Prochaska JH, Coldewey M, Göbel S, Keller K, Hendelmeier M, Konstantinides S, Münzel T, Wild PS; for the thrombEVAL Study Group. Evaluation of oral anticoagulation therapy: rationale and design of the thrombEVAL study programme. European journal of preventive cardiology. 2014.
Bova C, Sanchez O, Prandoni P, Lankeit M, Konstantinides S, Vanni S, Jiménez D. Identification of intermediate-risk patients with acute symptomatic pulmonary embolism. European Respiratory Journal. 2014.
Meyer G, Vicaut E, ... Lankeit M, ... Torbicki A, Verschuren F, and Konstantinides SV for the PEITHO Investigators. Fibrinolysis for Patients with Acute Intermediate-Risk Pulmonary Embolism. New England Journal of Medicine. 370:1402-11, 2014.
Dellas C, Tschepe M, Seeber V, Zwiener I, Kuhnert K, Schäfer K, Hasenfuß G, Konstantinides S, Lankeit M. A novel H-FABP assay and a fast prognostic score for risk assessment of normotensive pulmonary embolism. Thrombosis Haemostasis. 111(5):996-1003, 2014.
Navdaev A, Subramanian H, Petunin A, Clemetson KJ, Gambaryan S, Walter U. Echicetin Coated Polystyrene Beads: A Novel Tool to Investigate GPIb-Specific Platelet Activation and Aggregation. PLOS One. 9(4):e93569, 2014.
Jiang Y, McIntosh JJ, Reese JA, Deford CC, Kremer Hovinga JA, Lämmle B, Terrell DR, Vesely SK, Knudtson EJ, George JN. Pregnancy outcomes following recovery from acquired thrombotic thrombocytopenic purpura. Blood 123(11):1674-80, 2014.
Lankeit M, Jiménez D, Kostrubiec M, Dellas C, Kuhnert K, Hasenfuß G, Pruszczyk P, Konstantinides S. Validation of N-terminal pro-brain natriuretic peptide cut-off values for risk stratification of pulmonary embolism. European Respiratory Journal. 43(6):1669-77, 2014.
Jiménez D, Kopecna D, Tapson V, Briese B, Schreiber D, Lobo JL, Monreal M, Aujesky D, Sanchez O, Meyer G, Konstantinides S, Yusen RD. Derivation and validation of multimarker prognostication for normotensive patients with acute symptomatic pulmonary embolism. American Journal of Respiratory and Critical Care Medicine. 189(6):718-26, 2014.
Bosmann M, Strobl B, Kichler N, Rigler D, Grailer JJ, Pache F, Murray PJ, Müller M, Ward PA. Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27. Journal of Leukocyte Biology. 96(1):123-31, 2014.
Sinning C, Keller T, Zeller T, Ojeda F, Schlüter M, Schnabel R, Lubos E, Bickel C, Lackner KJ, Diemert P, Munzel T, Blankenberg S, Wild PS. Association of high-sensitivity assayed troponin I with cardiovascular phenotypes in the general population: the population-based Gutenberg health study. Clinical Research in Cardiology. 103(3):211-22, 2014.
Anaraki P, Patecki M, Larmann J, Tkachuk S, Jurk K, Haller H, Theilmeier G, Dumler I. Urokinase Receptor Mediates Osteogenic Differentiation of Mesenchymal Stem Cells and Vascular Calcification via the Complement C5a Receptor. Stem Cells and Development. 15;23(4):352-62, 2014.
Brandt M, Schönfelder T, Schwenk M, Becker C, Jäckel S, Reinhardt C, Stark K, Massberg S, Münzel T, von Brühl ML, Wenzel P. Deep vein thrombus formation induced by flow reduction in mice is determined by venous side branches. Clinical Hemorheology and Microcirculation. 56(2):145-52, 2014.
Beck F, Geiger J, Gambaryan S, Veit J, Vaudel M, Nollau P, Kohlbacher O, Martens L, Walter U, Sickmann A, Zahedi RP. Time-resolved characterization of camp/pka-dependant signaling reveals that platelet inhibition is a concerted process involving multiple signaling pathways. Blood. 123(5):e1-e10, 2014.
Kröller-Schön S, Steven S, Kossmann S, Scholz A, Daub S, Oelze M, Xia N, Hausding M, Mikhed Y, Zinßius E, Mader M, Stamm P, Treiber N, Scharffetter-Kochanek K, Li H, Schulz E, Wenzel P, Münzel T, Daiber A. Molecular Mechanisms of the Crosstalk Between Mitochondria and NADPH Oxidase Through Reactive Oxygen Species-Studies in White Blood Cells and in Animal Models. Antioxidants & Redox Signaling. 20(2):247-66, 2014.
Zwiener I, Frisch B, Binder H. Transforming RNA-Seq Data to Improve the Performance. PLOS ONE. 9(1): e85150, 2014.
Rocanin-Arjo A, Cohen W, ... Wild PS, ... Trégouët DA, Morange PE. A meta-analysis of genome-wide association studies identifies ORM1 as a novel gene controlling thrombin generation potential. Blood. 123(5):777-85, 2014.
Prüfer S, Weber M, Sasca D, Teschner D, Wölfel C, Stein P, Stassen M, Schild H, Radsak MP. Distinct Signaling Cascades of TREM-1, TLR and NLR in Neutrophils and Monocytic Cells. Journal Innate Immunology. 6(3): 339-352, 2014.
Jimenez-Alcazar M, Napirei M, Panda R, Kohler EC, Kremer-Hovinga JA, Mannherz HG, Peine S, Renne T, Lämmle B, Fuchs TA. Impaired DNase1-mediated degradation of neutrophil extracellular traps is associated with acute thrombotic microangiopathies. Journal of thrombosis and haemostasis, 13: 732-42. 2014.
Stroka D, Keogh A, Vu D, Fort A, Stoffel MH, Kuhni-Boghenbor K, Furer C, Banz V, Demarmels Biasiutti F, Lämmle B, Candinas D, Neerman-Arbez M. In vitro rescue of FGA deletion by lentiviral transduction of an afibrinogenemic patient's hepatocytes. Journal of thrombosis and haemostasis, 12: 1874-9. 2014.

Reviews 2014

Schönfelder T, Jäckel S, Wenzel P. Mouse models of deep vein thrombosis. Gefässchirurgie. 19:257–262, 2014.
Knorr M, Münzel T, Wenzel P. Interplay of NK cells and monocytes in vascular inflammation and myocardial infarction. Frontiers in physiology. 5:295, 2014.
Konstantinides SV, Torbicki A. Management of pulmonary embolism: recent evidence and the new European guidelines. The European respiratory journal. 44:1385-1390, 2014.
Konstantinides S, Torbicki A. Management of venous thrombo-embolism: an update. European heart journal, 2014.
Klok FA, van der Hulle T, den Exter PL, Lankeit M, Huisman MV, Konstantinides S. The post-PE syndrome: a new concept for chronic complications of pulmonary embolism. Blood reviews. 2014.
Kaberich A, Warntges S, Konstantinides S. Risk-adapted management of acute pulmonary embolism: recent evidence, new guidelines. Rambam Maimonides medical journal. 5:e0040, 2014.
Raskob GE, Angchaisuksiri P, Blanco AN, Büller H, Gallus A, Hunt BJ, Hylek EM, Kakkar TL, Konstantinides SV, McCumber M, Ozaki Y, Wendelboe A, Weitz JI. Thrombosis: a major contributor to global disease burden. Thrombosis and haemostasis. 112:843-852, 2014.
Clemens A, Strack A, Noack H, Konstantinides S, Brueckmann M, Lip GY. Anticoagulant-related gastrointestinal bleeding--could this facilitate early detection of benign or malignant gastrointestinal lesions? Annals of medicine. 46:672-678, 2014.
Lammle B, Walter U. Pearls, guidelines & more. Hamostaseologie. 34:199, 2014.
Ruf W, Schaffner F. Role of the protein C receptor in cancer progression. Thromb Res. 133 Suppl 2:S85-9, 2014.
Wilkens H, Lang I, Blankenburg T, Grohé C, Guth S, Held M, Klepetko W, Konstantinides S, Kramm T, Krüger U, Lankeit M, Schäfers HJ, Seyfarth HJ, Mayer E. Chronic thromboembolic pulmonary hypertension - A position paper. Deutsche Medizinische Wochenschrift. 2014 Aug 1. [Epub ahead of print] (P1C)
Marti C, John G, Konstantinides S, Combescure C, Sanchez O, Lankeit M, Meyer G, Perrier A. Systemic thrombolytic therapy for acute pulmonary embolism: a systematic review and meta-analysis. European Heart Journal. 2014 Jun 10. pii: ehu218.
Lankeit M, Konstantinides S; Aktuelle Therapie und Sekundärprävention der Lungenembolie; Gefässchirurgie - Zeitschrift für vaskuläre und endovaskuläre Medizin; 2014; 19: 77–90. CME-zertifizierte Fortbildung
Lankeit M, Konstantinides S. Thrombolyse bei akuter Lungenembolie – Risikostratifizierung, risikoadaptierte Diagnostik und Therapie. Klinikarzt. 2014. 433 (S1): 6-11. CME-zertifizierte Fortbildung
Klok FA, Kooiman J, Huisman MV, Konstantinides S, Lankeit M. Predicting anticoagulant-related bleeding in patients with venous thromboembolism: a clinically oriented review. European Respiratory Journal. 2014
Karbach S, Wenzel P, Waisman A, Munzel T, Daiber A. eNOS Uncoupling in Cardiovascular Diseases - the Role of Oxidative Stress and Inflammation. Current Pharmaceutical Design. 2014. 20(22):3579-94
Burkhart JM, Gambaryan S, Watson SP, Jurk K, Walter U, Sickmann A, Heemskerk JWM, Zahedi RP. What Can Proteomics Tell Us About Platelets?. Circulation Research 2014; 114:1204-1219
Bosmann M, Ward PA. Protein-based therapies for acute lung injury: targeting neutrophil extracellular traps. Expert Opinion on Therapeutic Targets 2014; 2014 Jun;18(6):703-14
Keller K, Beule J, Oliver Balzer J, Coldewey M, Munzel T, Dippold W, Wild P. A 56-year-old man with co-prevalence of Leriche syndrome and dilated cardiomyopathy: case report and review. Wiener Klinische Wochenschrift. 2014 Mar;126(5-6):163-8
Schulz E, Wenzel P, Munzel T, Daiber A. Mitochondrial Redox Signaling: Interaction of Mitochondrial Reactive Oxygen Species with Other Sources of Oxidative Stress. Antioxid Redox Signal 2014 Jan 10; 20(2):308-24
Langer F, Ruf W. Synergies of phosphatidylserine and protein disulfide isomerase in tissue factor activation. Thrombosis Haemostasis 2014 Jan 23;111(3)
Lutz J, Menke J, Sollinger D, Schinzel H, Thürmel K. Haemostasis in chronic kidney disease. Nephrology Dialysis Transplantation. 2014 Jan;29(1):29-40
Schinzel H, Weilemann LS. Monitoring of anticoagulation-management in practice. Deutsche Medizinische Wochenschrift. 2014 Jan;139 Suppl 1:S27-30
Jurk K. Analysis of platelet function and dysfunction. Hamostaseologie. 35, 2014.

Editorials und Fachbeiträge 2014

Konstantinides SV, Torbicki A, Agnelli G, Danchin N, Fitzmaurice D, Galie N, Gibbs JS, Huisman MV, Humbert M, Kucher N, Lang I, Lankeit M, Lekakis J, Maack C, Mayer E, Meneveau N, Perrier A, Pruszczyk P, Rasmussen LH, Schindler TH, Svitil P, Vonk Noordegraaf A, Zamorano JL, Zompatori M, Task Force for the D, Management of Acute Pulmonary Embolism of the European Society of C. 2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism. European heart journal. 35:3033-3069, 3069a-3069k, 2014.
- Corrigiendum
Beyer-Westendorf J, Konstantinides S, Kucher N. Akute Lungenembolie. In Mayet W-J, Mertens PR, Meyer J, Müller OA, Pfeifer M, Pletz MW, Schellinger P, Weiss N, Wendtner CM (Editors). Rationelle Diagnostik und Therapie in der Inneren Medizin. Elsevier, Urban & Fischer, 2014, ISBN 978-3-437-22838-4
Colucci G, Alberio L, Demarmels Biasiutti F, Lämmle B. Bilateral periorbital ecchymoses. An often missed sign of amyloid purpura. Hamostaseologie. 2014 Aug 5;34(3):249-52.
Hecking C, Hendelmeier M, von Bardeleben R, Gröschel K, Schinzel H. Recurrent cerebral ischaemia in a pregnant woman with patent foramen ovale II° and thrombophilia. Hamostaseologie 2014 Jun 30;34(3)
Beck O, Martin C, Alt F, Wingerter A, Staatz G, Schinzel H, Faber J. Massive pulmonary embolism in a young boy with T-cell leukaemia. Successful thrombolytic therapy by recombinant tissue plasminogen activator (rtPA). Hamostaseologie 2014 Jun 30;34(3)
Falter T, Kremer Hovinga JA, Lackner K, Füllemann HG, Lämmle B, Scharrer I. Late onset and pregnancy-induced congenital thrombotic thrombocytopenic purpura. Hamostaseologie 2014 Jul 4;34(3)
Konstantinides SV. Asthma and pulmonary embolism: bringing airways and vessels closer together. European Respiratory Journal 2014 Mar;43(3):694-6
Lankeit M, Konstantinides S. Aktuelle Therapie und Sekundärprävention der Lungenembolie. Gefässchirurgie - Zeitschrift für vaskuläre und endovaskuläre Medizin 2014; 19: 77–90

Originalartikel 2013

Bosmann M, Grailer JJ, Ruemmler R, Russkamp NF, Zetoune FS, Sarma JV, Standiford TJ, Ward PA. Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury. The FASEB Journal 2013 Dec; 27(12):5010-21
Erdmann J, Stark K, Esslinger UB, Rumpf PM, ... , Walter U; CARDIoGRAM, Ott J, Samani NJ, Strom TM, Meitinger T, Hengstenberg C, Schunkert H. Dysfunctional nitric oxide signalling increases risk of myocardial infarction. Nature 2013 Dec 19;504(7480):432-6.
Schnabel RB, Michal M, Wilde S, Wiltink J, Wild PS, Sinning CR, Lubos E, Ojeda FM, Zeller T, Munzel T, Blankenberg S, Beutel ME. Depression in atrial fibrillation in the general population. PLoS One 2013 Dec 4;8(12):e79109.
Rukoyatkina N, Mindukshev I, Walter U, Gambaryan S. Dual role of the p38 MAPK/cPLA2 pathway in the regulation of platelet apoptosis induced by ABT-737 and strong platelet agonists. Cell Death and Disease 2013 Nov 21;4:e931
Oelze M, Knorr M, Kroller-Schon S, Kossmann S, Gottschlich A, Rummler R, Schuff A, Daub S, Doppler C, Kleinert H, Gori T, Daiber A, Munzel T. Chronic therapy with isosorbide-5-mononitrate causes endothelial dysfunction, oxidative stress, and a marked increase in vascular endothelin-1 expression. European Heart Journal 2013 Nov;34(41):3206-16
Hausding M, Jurk K, Daub S, Kröller-Schön S, Stein J, Schwenk M, Oelze M, Mikhed Y, Kerahrodi JG, Kossmann S, Jansen T, Schulz E, Wenzel P, Reske-Kunz AB, Becker C, Münzel T, Grabbe S, Daiber A. CD40L contributes to angiotensin II-induced pro-thrombotic state, vascular inflammation, oxidative stress and endothelial dysfunction. Basic Research in Cardiology 2013 Nov; 108(6):386.
Lankeit M, Dellas C, Benz V, Hasenfuß G, Konstantinides S. The predictive value of heart-type fatty acid-binding protein is independent from symptom duration in normotensive patients with pulmonary embolism. Thrombosis Research 2013 Nov;132(5):543-7
Tenzer S, Docter D, Kuharev J, Musyanovych A, Fetz V, Hecht R, Schlenk F, Fischer D, Kiouptsi K, Reinhardt C, Landfester K, Schild H, Maskos M, Knauer SK, Stauber RH. Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology. Nature Nanotechnology 2013 Oct; 8(10):772-81
Wiltink J, Michal M, Wild PS, Zwiener I, Blettner M, Münzel T, Schulz A, Kirschner Y, Beutel ME. Associations between depression and different measures of obesity (BMI, WC, WHtR, WHR). BMC Psychiatry 2013 Sep 12;13:223
Casper I, Nowag S, Koch K, Hubrich T, Bollmann F, Henke J, Schmitz K, Kleinert H, Pautz A. Post-transcriptional regulation of the human inducible nitric oxide synthase (iNOS) expression by the cytosolic poly(A)-binding protein (PABP). Nitric Oxide 2013 Sep 1; 33:6-17
Schroeter MR, Leifheit-Nestler M, Hubert A, Schumann B, Glückermann R, Eschholz N, Krüger N, Lutz S, Hasenfuss G, Konstantinides S, Schäfer K. Leptin promotes neointima formation and smooth muscle cell proliferation via NADPH oxidase activation and signalling in caveolin-rich microdomains. Cardiovascular Research 2013 Aug 1;99(3):555-65
Subramanian H, Zahedi RP, Sickmann A, Walter U, Gambaryan S; Phosphorylation of CalDAG-GEFI by Protein Kinase A prevents Rap1b activation. Journal of Thrombosis and Haemostasis 2013 Aug; 11(8):1574-82
Bottolo L, Chadeau-Hyam M, Hastie DI, Zeller T, Liquet B, Newcombe P, Yengo L, Wild PS, Schillert A, Ziegler A, Nielsen SF, Butterworth AS, Ho WK, Castagné R, Munzel T, Tregouet D, Falchi M, Cambien F, Nordestgaard BG, Fumeron F, Tybjærg-Hansen A, Froguel P, Danesh J, Petretto E, Blankenberg S, Tiret L, Richardson S. GUESS-ing polygenic associations with multiple phenotypes using a GPU-based evolutionary stochastic search algorithm. PLoS Genetics 2013 Aug;9(8):e1003657
Reiner AP, Hartiala J, Zeller T, Bis JC, Dupuis J, Fornage M, Baumert J, Kleber ME, Wild PS, Baldus S, Bielinski SJ, Fontes JD, Illig T, Keating BJ, Lange LA, Ojeda F, Muller-Nurasyid M, Munzel TF, Psaty BM, Rice K, Rotter JI, Schnabel RB, Tang WH, Thorand B, Erdmann J, Consortium C, Jacobs DR, Jr., Wilson JG, Koenig W, Tracy RP, Blankenberg S, Marz W, Gross MD, Benjamin EJ, Hazen SL, Allayee H. Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia. Human Molecular Genetics 2013 Aug 15; 22(16):3381-93
Kröller-Schön S, Jansen T, Schüler A, Oelze M, Wenzel P, Hausding M, Kerahrodi JG, Beisele M, Lackner KJ, Daiber A, Münzel T, Schulz E. Peroxisome proliferator-activated receptor γ, coactivator 1α deletion induces angiotensin II-associated vascular dysfunction by increasing mitochondrial oxidative stress and vascular inflammation. Arteriosclerosis, Thrombosis and Vascular Biololgy 2013 Aug; 33(8):1928-35
Leifheit-Nestler M, Wagner NM, Gogiraju R, Didié M, Konstantinides S, Hasenfuss G, Schäfer K. Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity. Journal of Translational Medicine 2013 Jul 11;11:170
Bosmann M, Haggadone MD, Zetoune FS, Sarma JV, Ward PA. The interaction between C5a and both C5aR and C5L2 receptors is required for production of G-CSF during acute inflammation. European Journal of Immunology 2013 Jul; 43(7):1907-13
Schnabel RB, Biener MP, Wilde S, Sinning CR, Ojeda FM, Zeller T, Lubos E, Lackner KJ, Warnholtz A, Gori T, Espinola-Klein C, Blankenberg S, Munzel T, Wild PS. Sex differences in noninvasive vascular function in the community. Journal of Hypertension 2013 Jul;31(7):1437-46
Fehrmanna C, Jurk K, Bertling A, Seidel G, Fegeler W, Kehrel BE, Peters G, Becker K, Heilmanna C. Role for the fibrinogen-binding proteins Coagulase and Efb in the Staphylococcus aureus–Candida interaction. International Journal of Medical Microbiology 2013 Jul; 303(5):230-8
Nuebling M, Seidler A, Garthus-Niegel S, Latza U, Wagner M, Hegewald J, Liebers F, Jankowiak S, Zwiener I, Wild PS, Letzel S. The Gutenberg Health Study: measuring psychosocial factors at work and predicting work-related outcomes with the ERI and the COPSOQ questionnaire. BMC Public Health 2013 Jun 4; 13:538
Kossmann S, Schwenk M, Hausding M, Karbach SH, Schmidgen MI, Brandt M, Knorr M, Hu H, Kröller-Schön S, Schönfelder T, Grabbe S, Oelze M, Daiber A, Münzel T, Becker C, Wenzel P. Angiotensin II-Induced Vascular Dysfunction Depends on Interferon-γ -Driven Immune Cell Recruitment and Mutual Activation of Monocytes and NK-Cells. Arteriosclerosis, Thrombosis, and Vascular Biology 2013 Jun; 33(6):1313-1319
Neumann JT, Tzikas S, Funke-Kaiser A, Wilde S, Appelbaum S, Keller T, Ojeda-Echevarria F, Zeller T, Zwiener I, Sinning CR, Jagodzinski A, Schnabel RB, Lackner KJ, Munzel T, Blankenberg S, Wild PS, Sydow K. Association of MR-proadrenomedullin with cardiovascular risk factors and subclinical cardiovascular disease. Atherosclerosis 2013 Jun; 228(2):451-9
Falter T, Alber KJ, Scharrer I. Long term outcome and sequelae in patients after acute thrombotic thrombocytopenic purpura episodes. Hämostaseologie 2013 May 29; 33(2):113-20
Schroeter MR, Eschholz N, Herzberg S, Jerchel I, Leifheit-Nestler M, Czepluch FS, Chalikias G, Konstantinides S, Schäfer K. Leptin-dependent and leptin-independent paracrine effects of perivascular adipose tissue on neointima formation. Arteriosclerosis, Thrombosis and Vascular Biololgy 2013 May; 33(5):980-7
Tzikas S, Keller T, Wild PS, Schulz A, Zwiener I, Zeller T, Schnabel RB, Sinning C, Lubos E, Kunde J, Munzel T, Lackner KJ, Blankenberg S. Midregional pro-atrial natriuretic peptide in the general population/Insights from the Gutenberg Health Study. Clinical Chemistry and Laboratory Medicine 2013 May; 51(5):1125-33
Mollnau H, Oelze M, Zinßius E, Hausding M, Wu Z, Knorr M, Ghaemi Kerahrodi J, Kröller-Schön S, Jansen T, Teutsch C, Foster C, Li H, Wenzel P, Schulz E, Münzel T, Daiber A. Effects of telmisartan or amlodipine monotherapy versus telmisartan/amlodipine combination therapy on vascular dysfunction and oxidative stress in diabetic rats. Naunyn-Schmiedebergs Arch Pharmacology 2013 May; 386(5):405-19
Gambaryan, Subramanian H, Rukoyatkina N, Herterich S, Walter U. Soluble guanylyl cyclase is the only enzyme responsible for cyclic guanosine monophosphate synthesis in human platelets. Journal of Thrombosis and Haemostasis 2013 May 2; 109(5):973-5
Bosmann M, Grailer JJ, Russkamp NF, Ruemmler R, Zetoune FS, Sarma JV, Ward PA. CD11c+ Alveolar Macrophages are a Source of IL-23 during LPS-induced Acute Lung Injury. Shock 2013 May; 39(5):447-52
Michal M, Wiltink J, Lackner K, Wild PS, Zwiener I, Blettner M, Muenzel T, Schulz A, Kirschner Y, Beutel ME. Association of hypertension with depression in the community: results from the Gutenberg Health Study. Journal of Hypertension 2013; 31(5): 893-899
Michal M, Wiltink J, Reiner I, Kirschner Y, Wild PS, Schulz A, Zwiener I, Blettner M, Beutel ME. Association of mental distress with smoking status in the community: Results from the Gutenberg Health Study. JOURNAL OF AFFECTIVE DISORDERS 2013 Apr 25; 146(3):355-60
Bollmann F, Fechir K, Nowag S, Koch K, Art J, Kleinert H, Pautz A. Human inducible nitric oxide synthase (iNOS) expression depends on chromosome region maintenance 1 (CRM1)- and eukaryotic translation initiation factor 4E (elF4E)-mediated nucleocytoplasmic mRNA transport. Nitric Oxide 2013 Apr 1; 30:49-59
van der Loos MJ, Rietveld CA, ... Wild PS... Hofman A, Thurik AR. The molecular genetic architecture of self-employment. PLoS One 2013 Apr 4; 8(4):e60542
Bosmann M, Meta F, Ruemmler R, Haggadone MD, Sarma JV, Zetoune FS, Ward PA. Regulation of IL-17 Family Members by Adrenal Hormones During Experimental Sepsis in Mice. American Journal of Pathology 2013 Apr; 182(4):1124-30
Tzikas S, Keller T, Ojeda FM., Zeller T, Wild PS, Lubos E, Kunde J, Baldus S, Bickel C, Lackner KJ, Muenzel TF, Blankenberg S. MR-proANP and MR-proADM for risk stratification of patients with acute chest pain. Heart 2013 Mar; 99(6):388-95
Schweigel H, Geiger J, Beck F, Buhs S, Gerull H, Walter U, Sickmann A, Nollau P. Deciphering of ADP-induced, phosphotyrosinedependent signaling networks in human platelets by Src-homology 2 region (SH2)-profiling. Proteomics 2013 Mar;13(6):1016-27
Koettgen A, Albrecht E ... Wild PS ... , Bochud M, Gieger C. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. NATURE GENETICS 2013 Feb; 45(2):145-54
Bugl S, Wirths S, Radsak M, Schild H, Stein P, André M, Müller M, Malenke E, Wiesner T, Märklin M, Frick J, Handgretinger R, Rammensee H, Kanz L and Kopp H. Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling. Blood 2013 Jan 31; 121(5):723-33
Deloukas P, Kanoni S ... Wild PS ... Schunkert H, Samani NJ. Large-scale association analysis identifies new risk loci for coronary artery disease. NATURE GENETICS 2013 Jan; 45(1):25-33
Verdugo RA, Zeller T, Rotival M, Wild PS, Munzel T, Lackner KJ, Weidmann H; Ninio E, Tregouet DA, Cambien F, Blankenberg S, Tiret L. Graphical modeling of gene expression in monocytes suggests molecular mechanisms explaining increased atherosclerosis in smokers. Plos One 2013; 8(1):e50888
Begonja AJ, Gambaryana S, Schulzed H, Patel-Hett S, Italiano JE, Hartwigb JH, Walter U. Differential roles of cAMP and cGMP in megakaryocyte maturation and platelet biogenesis. Experimental Hematology 2013;41:91–101
Hausding M, Jurk K, Daub S, Kröller-Schön S, Stein J, Schwenk M, Oelze M, Mikhed Y, Ghaemi Kerahrodi J, Kossmann S, Jansen T, Schulz E, Wenzel P, Reske-Kunz AB, Becker C, Münzel T, Grabbe S, Daiber A. CD40L contributes to angiotensin II-induced pro-thrombotic state, vascular inflammation, oxidative stress and endothelial dysfunction. Basic Research in Cardiology 2013; 108:386
Garnier S, Truong V, Brocheton J, Zeller T, Rovital M, Wild PS, Ziegler A; Cardiogenics Consortium, Munzel T, Tiret L, Blankenberg S, Deloukas P, Erdmann J, Hengstenberg C, Samani NJ, Schunkert H, Ouwehand WH, Goodall AH, Cambien F, Trégouët DA. Genome-wide haplotype analysis of cis expression quantitative trait loci in monocytes. PLoS Genet. 2013;9(1):e1003240.

Reviews 2013

Bosmann M, Ward PA. 2013. Modulation of inflammation by interleukin-27. J Leukoc Biol. 94:1159-1165, 2013.
Lankeit M, Konstantinides S. Aktuelle Therapie und Sekundärprävention der Lungenembolie. Pneumologe 2013 2013 Nov; 443-456. CME-zertifizierte Fortbildung
Lankeit M, Konstantinides S. Aktuelle Therapie und Sekundärprävention der Lungenembolie. Der Kardiologe 2013; 7:217-230. doi:10.1007/s12181-013-0481-8. CME-zertifizierte Fortbildung
Danckwardt S, Hentze MW, Kulozik AE. Pathologies at the nexus of blood coagulation and inflammation: thrombin in hemostasis, cancer, and beyond. Journal of Molecular Medicine 2013 Nov; 91(11):1257-71.
Versteeg H. H., Ruf W. New helpers in TF-dependent migration. Journal of Thrombosis and Haemostasis 2013 Oct; 11(10): 1877-9
Münzel T, Daiber A, Gori T. More answers to the still unresolved question of nitrate tolerance. European Heart Journal. 2013 Sep; 34(34):2666-73
den Exter P.L, van der Hulle T, Lankeit M, Huisman M.V., Klok F.A. Long-term clinical course of acute pulmonary embolism. Blood Reviews 2013 Jul; 27(4):185-92.
Li H, Horke S, Förstermann U. Oxidative stress in vascular disease and its pharmacological prevention Trends in Pharmacological Sciences. Trends Pharmacol Science 2013 Jun; 34(6):313-9
Konstantinides S, Lankeit M. Pulmonary embolism hotline 2012. Recent and expected trials. Hamostaseologie 2013 Feb; 33(1):43-50.

Editorials und Fachbeiträge 2013

Mirshahi A, Ponto KA, Hohn R, Wild PS, Pfeiffer N. Ophthalmological aspects of the Gutenberg Health Study (GHS): an interdisciplinary prospective population-based cohort study. Ophthalmologe 2013 Mar; 110(3):210-7 (P1B)
Lankeit M, Konstantinides S. Lungenembolie - Update 2013. Deutsche Medizinische Wochenschrift 138. Jahrgang, 31/32 2013 (P1C)
Konstantinides S, Lankeit M. Diagnostik im Dialog. News der Roche Diagnostics Deutschland GmbH 2013, Ausgabe 39, 2/2013 (P1C)
Schinzel H, Hendelmeier M. Therapie der frischen tiefen Beinvenenthrombose. Deutsche Medizinische Wochenschrift 2013, 138: 786-791
Konstantinides S, Lankeit M. Risikostratifizierung bei Lungenembolie: Stellwert kardialer Troponine. Diagnostik im Dialog 2013; Ausgabe 29, 2/2013 (JG1C)

Originalartikel 2012

Bosmann M, Russkamp NF, Ward PA. Fingerprinting of the TLR4-induced acute inflammatory response. Experimental and Molecular Pathology 2012 Dec; 93(3):319-23
Schurmann C, Heim K, Schillert A, Blankenberg S, Carstensen M, Dörr M, Endlich K, Felix SB, Gieger C, Grallert H, Herder C, Hoffmann W, Homuth G, Illig T, Kruppa J, Meitinger T, Müller C, Nauck M, Peters A, Rettig R, Roden M, Strauch K, Völker U, Völzke H, Wahl S, Wallaschofski H, Wild PS, Zeller T, Teumer A, Prokisch H, Ziegler A. Analyzing illumina gene expression microarray data from different tissues: methodological aspects of data analysis in the metaxpress consortium. PLOS one 2012 Dec; 7(12):e50938
Kröller-Schön S, Knorr M, Hausding M, Oelze M, Schuff A, Schell R, Sudowe S, Scholz A, Daub S, Karbach S, Kossmann S, Gori T, Wenzel P, Schulz E, Grabbe S, Klein T, Münzel T, Daiber A. Glucose Independent Improvement of Vascular Dysfunction in Experimental Sepsis by Dipeptidyl-Peptidase 4 Inhibition. Cardiovascular Research 2012 Oct 1; 96(1):140-9
Burkhart J, Vaudel M, Gambaryan S, Radau S, Walter U, Martens L, Geiger J, Sickmann A, Zahedi R. The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways. Blood 2012 Oct 11;120(15):e73-82
Siuda D, Zechner U, El Hajj N, Prawitt D, Langer D, Xia N, Horke S, Pautz A, Kleinert H, Förstermann U, Li H. Transcriptional regulation of Nox4 by histone deacetylases in human endothelial cells. Basic Research in Cardiology 2012 Sep; 107:283
Schnabel R, Wild P, Schulz A, Zeller T, Sinning C, Wilde S, Kunde J, Lubos E, Lackner K, Warnholtz A, Gori T, Blankenberg S, Munzel T. Multiple Endothelial Biomarkers and Noninvasive Vascular Function in the General Population The Gutenberg Health Study. Hypertension 2012 Aug; 60(2):288-95
Kroller-Schon S, Jansen T, Hauptmann F, Schuler A, Heeren T, Hausding M, Oelze M, Viollet B, Keaney JF, Jr., Wenzel P, Daiber A, Munzel T, Schulz E. alpha1AMP-Activated Protein Kinase Mediates Vascular Protective Effects of Exercise. Arteriosclerosis Thrombosis and Vascular Biology 2012 Jul; 32(7):1632-41
Closs E, Ostad M, Simo A, Warnholtz A, Jabs A, Habermeier A, Daiber A, Förstermann U, Münzel T. Impairment of the extrusion transporter for asymmetric dimethyl-L-arginine: a novel mechanism underlying vasospastic angina. Biochem. Biophys. Res. Commun 2012 Jun 29; 423(2):218-23
Wild P, Zeller T, Beutel M, Blettner M, Dugi K, Lackner K, Pfeiffer N, Munzel T, Blankenberg S. Die Gutenberg Gesundheitsstudie. Bundesgesundheitsblatt-Gesundheitsforschung-Gesundheitsschutz 2012 Jun, Volume 55; Issue: 6-7; Pages: 824-829
Gambaryan S, Friebe A, Walter U. Does the NO/sGC/cGMP/PKG pathway play a stimulatory role in platelets? Blood 2012 May; 119:5335-5336
Schnabel RB, Wilde S, Wild PS, Munzel T, Blankenberg S. Atrial Fibrillation: Its Prevalence and Risk Factor Profile in the German General Population. Deutsches Ärzteblatt International 2012 Apr; 109(16):293-9
Reinhardt C, Bergentall M, Greiner TU, Schaffner F, Ostergren-Lundén G, Petersen LC, Ruf W, Bäckhed F. Tissue factor and PAR1 promote microbiota-induced intestinal vascular remodeling. Nature 2012 Mar 11; 483(7391):627-31
Wild P, Schnabel R, Lubos E, et al. Midregional Proadrenomedullin for Prediction of Cardiovascular Events in Coronary Artery Disease: Results from the AtheroGene Study. Clinical Chemistry 2012 Jan; 58(1):226-36
Torzewski M, Wenzel P, Kleinert H, Becker C, El-Masri J, Wiese E, Brandt M, Pautz A, Twardowski L, Schmitt E, Münzel T, Reifenberg K. Chronic Inflammatory Cardiomyopathy of Interferon gamma-Overexpressing Transgenic Mice Is Mediated by Tumor Necrosis Factor-alpha. American Journal of Pathology 2012 Jan; 180(1):73-81
Knorr M, Hausding M, Schulz E, Oelze M, Rümmler R, Schuff A, Daub S, Schreiner J, Kröller-Schön S, Wenzel P, Gori T, Burgin K, Sartor D, Scherhag A, Münzel T, Daiber A. Characterization of new organic nitrate hybrid drugs covalently bound to valsartan and cilostazol. Pharmacology 2012; 90(3-4):193-204
Gladigau G, Haselmayre P, Scharrer I, Munder M, Prinz N, Lackner K, Schild H, Stein P, Radsak M. A Role for Toll-Like Receptor Mediated Signals in Neutrophils in the Pathogenesis of the Anti-Phospholipid Syndrome. PLOS one 2012; 7(7): e42176

Reviews 2012

Konstantinides S, Goldhaber SZ. Pulmonary embolism: risk assessment and management. European Heart Journal 2012 Dec; 33(24):3014-22
Nickel K, Renné T. Crosstalk of the plasma contact system with bacteria.Thrombosis Research 2012 Oct; 130 Suppl 1:S78-83
Renné T, Schmaier AH, Nickel KF, Blombäck M, Maas C. In vivo roles of factor XII. Blood 2012 Sep, 120: 4296-4303
Renné T. The procoagulant and proinflammatory plasma contact system. Seminars in Immunopathology 2012 Aug; 34:31-41
Mass C, Renné T. Regulatory mechanisms of the plasma contact system. Thrombosis Research 2012 May; 129 Suppl 2:S73-6
Konstantinides S, Münzel T. Apixaban. Hamostaseologie 2012; 32(3):203-11
Daiber A, Oelze M, Wenzel P, Bollmann F, Pautz A, Kleinert H. Heme Oxygenase-1 Induction and Organic Nitrate Therapy: Beneficial Effects on Endothelial Dysfunction, Nitrate Tolerance, and Vascular Oxidative Stress. International Journal of Hypertension 2012; 2012:842632, doi:10.1155/2012/842632 (TRP A1, A2)

Editorials und Fachbeiträge 2012

Bollmann F, Casper I, Henke J, Pautz A. qRT-PCR: a method and its difficulties. Naunyn Schmiedebergs Arch Pharmacology 2012 Oct; 385(10):949-51

Originalartikel 2011

Kroller-Schon S, Schulz E, Wenzel P, Kleschyov A, Hortmann M, Torzewski M, Oelze M, Renne T, Daiber A, Munzel T. Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress. Basic Research in Cardiology 2011 Nov; 106:1147-1158
Schuhmacher S, Oelze M, Bollmann F, Kleinert H, Otto C, Heeren T, Steven S, Hausding M, Knorr M, Pautz A, Reifenberg K, Schulz E, Gori T, Wenzel P, Munzel T, Daiber A. Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapy. Diabetes 2011 Oct; 60:2608-2616
Knorr M, Hausding M, Kroller-Schuhmacher S, Steven S, Oelze M, Heeren T, Scholz A, Gori T, Wenzel P, Schulz E, Daiber A, Munzel T. Nitroglycerin-induced endothelial dysfunction and tolerance involve adverse phosphorylation and S-Glutathionylation of endothelial nitric oxide synthase: beneficial effects of therapy with the AT1 receptor blocker telmisartan. Arteriosclerosis Thrombosis and Vascular Biology 2011 Oct; 31(10):2223-31
Wenzel P, Knorr M, Kossmann S, Stratmann J, Hausding M, Schuhmacher S, Karbach S, Schwenk M, Yogev N, Schulz E, Oelze M, Grabbe S, Jonuleit H, Becker C, Daiber A, Waisman A, Münzel T. Lysozyme M–Positive Monocytes Mediate Angiotensin II-Induced Arterial Hypertension and Vascular Dysfunction. Circulation 2011 Sept; 124:1370-1381
Schuhmacher S, Foretz M, Knorr M, Jansen T, Hortmann M, Wenzel P, Oelze M, Kleschyov A, Daiber A, Keaney J, Wegener G, Lackner K, Münzel T, Viollet B, Schulz E. α 1AMP-activated protein kinase preserves endothelial function during chronic angiotensin II treatment by limiting Nox2 upregulation. Arteriosclerosis Thrombosis and Vascular Biology 2011 Mar; 31(3):560-6

Reviews 2011

Müller F, Gailani D, Renné T. Factor XI and XII as antithrombotic targets. Current Opinion in Hematology 2011 Sep; 18(5):349-55
Münzel T, Daiber A, Gori T. Nitrate Therapy: New Aspects Concerning Molecular Action and Tolerance. Circulation 2011 May; 123(5); 2132-2144
Damaske A, Muxel S, Fasola F, Radmacher MC, Schaefer S, Jabs A, Orphal D, Wild P, Parker JD, Fineschi M, Munzel T, Forconi S, Gori T. Peripheral hemorheological and vascular correlates of coronary blood flow. Clinical Hemorheology and Microcirculation 2011; 49(1-4):261-9

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Letzte Aktualisierung: 11.07.2019

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