Visual Universitätsmedizin Mainz

Curriculum Vitae german

Hartmut Lüddens, PhD

Hartmut Lüddens, PhD

Professor of Molecular Psychopharmacology
University of Mainz Department of Psychiatry
Untere Zahlbacher Str. 8
D-55101 Mainz, Germany

Tel. +49-6131 17-5372


1972-1978 Study of biology at the University of Kiel and University of Reykjavik

Academic Appointments

1978 Graduate student at the Institute of Biochemistry, University of Kiel

1978-1983 Postgraduate fellow at the Institute of Biochemistry, University of Kiel

1983 PhD thesis on ACTH receptors

1984-1987 Research fellow at the Laboratory of Neurosciences, NIH, Bethesda, Maryland

1987-1995 Research fellow at the Laboratory of Molecular Neuroendocrinology, ZMBH, University of Heidelberg

1994 Venia legendi in the field of Biochemistry on GABAA receptors

1995 Head of the "Clinical Research Group" at the Department of Psychiatry, University of Mainz

1996 Nomination for Professor of Molecular Psychopharmacology

since 1996 Head of the Laboratory of Molecular Biology, Department of Psychiatry, University of Mainz

The Workgroup


Research Interests

The research group focuses on the pharmacology, physiology and biochemistry of the heteropentameric g-aminobutyric acid typ A (GABAA) receptors as well as some aspects of GABA transporter systems. The plasmamembrane inserted GABAA receptors belong to the largesuper family of ligand-gated ion-channels. The GABAA channel opens upon binding of the neurotransmitter GABA, allowing Cl- to follow its gradient and by thus hyperpolarizing, i.e., inhibiting, the cell. GABAA receptors are the targets of numerous drugs, e.g., benzodiazepines, barbiturates, some steroids and possibly ethanol.
We evaluate properties of native GABAA receptors with electrophysiological (patch-clamp) and pharmacological methods (ligand binding on transient transfected cell membranes, native receptor preparations, ligand autoradiography). These studies are combined with molecular biology approaches, in which we generate chimeric and point mutated proteins. Our aim is to identify functional domains on individual GABAA receptor subunits contributing to the pharmacological, or physiological and/or pathophysiological properties of the resulting receptor channels.



Currently supported by the Deutsche Forschungsgemeinschaft, Bundesministerium fuer Bildung und Forschung