International Medical Services
AG Kühn
- Arbeitsgruppenleiter:in: Dr. med. Michael Kühn
- Forschungsschwerpunkte:
The Kühn laboratory is based at the Department of Hematology, Oncology, and Pneumology at the University Medical Center of the Johannes Gutenberg-University of Mainz.
The primary focus of the laboratory is the biology and treatment of leukemia with a particular focus on acute myeloid leukemia. We are specifically interested in epigenetic alterations that control leukemogenic gene expression programs.
Our scientific efforts are committed to the development of new therapies against leukemia that are less toxic and more efficacious.
- Fünf wichtigste Publikationen:
Kühn MWM, Song E, Feng Z, Sinha A, Chen CW, Deshpande AJ, Cusan M, Rahnamay Farnoud N, Mupo A, Grove C, Koche R, Bradner JE, de Stanchina E, McGeehan G, Vassiliou GS, Hoshii T, and Armstrong SA. Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia. Cancer Discov. 2016;6(10):1166-81.
Kühn MWM and Armstrong SA. Designed to kill: Novel menin-MLL inhibitors target MLL-rearranged leukemia. Cancer Cell. 2015;27(4):431-3. Preview Article
Kühn MWM*, Hadler MJ*, Daigle SR, Koche RP, Krivtsov AV, Olhava EJ, Caligiuri MA, Huang G, Bradner JE, Pollock RM, Armstrong SA. MLL-PTD leukemia cells are sensitive to small molecule DOT1L inhibition. Haematologica. 2015;100(5):e190-3. *equal contribution
Kühn MWM, Bullinger L, Gröschel S, Krönke J, Edelmann J, Rücker FG, Eiwen K, Paschka P, Gaidzik VG, Holzmann K, Schlenk RF, Döhner H, Döhner K. Genome-wide genotyping of acute myeloid leukemia with translocation t(9;11)(p22;q23) reveals novel recurrent genomic alterations. Haematologica. 2014;99(8):e133-5.
Krönke J, Bullinger L, Teleanu V, Tschürtz F, Gaidzik VI, Kühn MWM, Rücker FG, Holzmann K, Paschka P, Kapp-Schwörer S, Späth D, Kindler T, Schittenhelm M, Krauter J, Ganser A, Göhring G, Schlegelberger B, Schlenk RF, Döhner H, Döhner K. Clonal evolution in relapsed NPM1 mutated acute myeloid leukemia. Blood. 2013;122(1):100-8.
- Ansprechpartner:in:
Dr. med. Michael Kühn
Tel: 06131 17-2710
E-Mail: michael.kuehn@unimedizin-mainz.de
