Publications by the Fellows

2022

• Haist M, Stege H, Lang BM, Tsochataridou A, Salzmann M, Mohr P, Schadendorf D, Ugurel S, Placke JM, Weichenthal M, Gutzmer R, Leiter U, Kaatz M, Haferkamp S, Berking C, Heppt M, Tschechne B, Schummer P, Gebhardt C, Grabbe S, Loquai C.
  Response to First-Line Treatment with Immune-Checkpoint Inhibitors in Patients with Advanced Cutaneous Squamous Cell Carcinoma: A Multicenter, Retrospective Analysis from the German ADOReg Registry.
  Cancers (Basel). 2022 Nov 11;14(22):5543. doi: 10.3390/cancers14225543. PMID: 36428636; PMCID: PMC9688854.
  
  
• Klaus T, Wilson AS, Vicari E, Hadaschik E, Klein M, Helbich SS, Kamenjarin N, Hodapp K, Schunke J, Haist M, Butsch F, Probst HC, Enk AH, Mahnke K, Waisman A, Bednarczyk M, Bros M, Bopp T, Grabbe S.
  Impaired regulatory T cell-dendritic cell interactions contribute to autoimmunity in leukocyte adhesion deficiency type-1.
  JCI Insight. 2022 Nov 8:e162580. doi: 10.1172/jci.insight.162580. Epub ahead of print. PMID: 36346673.
  
  
• Brummer T, Zipp F, Bittner S.
  T cell-neuron interaction in inflammatory and progressive multiple sclerosis biology.
  Curr Opin Neurobiol. 2022 Aug;75:102588. doi: 10.1016/j.conb.2022.102588. Epub 2022 Jun 19. PMID: 35732103.
  
  
• Bednarczyk M, Bolduan V, Haist M, Stege H, Hieber C, Johann L, Schelmbauer C, Blanfeld M, Karram K, Schunke J, Klaus T, Tubbe I, Montermann E, Röhrig N, Hartmann M, Schlosser J, Bopp T, Clausen BE, Waisman A, Bros M, Grabbe S.
  β2 Integrins on Dendritic Cells Modulate Cytokine Signaling and Inflammation-Associated Gene Expression, and Are Required for Induction of Autoimmune Encephalomyelitis.
  Cells. 2022 Jul 13;11(14):2188. doi: 10.3390/cells11142188. PMID: 35883631; PMCID: PMC9322999.
  
  
• Brummer T, Muthuraman M, Steffen F, Uphaus T, Minch L, Person M, Zipp F, Groppa S, Bittner S, Fleischer V.
  Improved prediction of early cognitive impairment in multiple sclerosis combining blood and imaging biomarkers.
  Brain Commun. 2022 Jul 8;4(4):fcac153.
  doi: 10.1093/braincomms/fcac153. PMID: 35813883; PMCID: PMC9263885.
  
  
• Brummer T, Muthuraman M, Steffen F, Uphaus T, Minch L, Person M, Zipp F, Groppa S, Bittner S, Fleischer V.
  Improved prediction of early cognitive impairment in multiple sclerosis combining blood and imaging biomarkers.
  2022 Jul 08;4(4):fcac153. 
  
  
• Brummer T, Zipp F, Bittner S.
  T cell-neuron interaction in inflammatory and progressive multiple sclerosis biology.
  2022 Jun 19;75:102588.

• Haist M, Ries F, Gunzer M, Bednarczyk M, Siegel E, Kuske M, Grabbe S, Radsak M, Bros M, Teschner D.
  Neutrophil-Specific Knockdown of β2 Integrins Impairs Antifungal Effector Functions and Aggravates the Course of Invasive Pulmonal Aspergillosis.
  Front Immunol. 2022 Jun 6;13:823121. doi: 10.3389/fimmu.2022.823121. PMID: 35734179; PMCID: PMC9207500.
  
  
• Kaps L, Schleicher EM, Medina Montano C, Bros M, Gairing SJ, Ahlbrand CJ, Michel M, Klimpke P, Kremer WM, Holtz S, Boedecker-Lips SC, Galle PR, Kraus D, Schattenberg JM, Labenz C, Weinmann-Menke J.
  Influence of Advanced Organ Support (ADVOS) on Cytokine Levels in Patients with Acute-on-Chronic Liver Failure (ACLF).
  J Clin Med. 2022 May 15;11(10):2782. doi: 10.3390/jcm11102782. PMID: 35628913; PMCID: PMC9144177.
  
  
• Kaps L, Schleicher EM, Medina Montano C, Bros M, Gairing SJ, Ahlbrand CJ, Michel M, Klimpke P, Kremer WM, Holtz S, Boedecker-Lips SC, Galle PR, Kraus D, Schattenberg JM, Labenz C, Weinmann-Menke J.
  Influence of Advanced Organ Support (ADVOS) on Cytokine Levels in Patients with Acute-on-Chronic Liver Failure (ACLF).
  J Clin Med. 2022 May 15;11(10):2782. doi: 10.3390/jcm11102782. PMID: 35628913; PMCID: PMC9144177.
  
  
• Haist M, Stege H, Ebner R, Fleischer MI, Loquai C, Grabbe S.
  The Role of Treatment Sequencing with Immune-Checkpoint Inhibitors and BRAF/MEK Inhibitors for Response and Survival of Patients with BRAFV600-Mutant Metastatic Melanoma-A Retrospective, Real-World Cohort Study.
  Cancers (Basel). 2022 Apr 21;14(9):2082. doi: 10.3390/cancers14092082. PMID: 35565212; PMCID: PMC9101790.
  
  
• Kuske M, Haist M, Jung T, Grabbe S, Bros M.
  Immunomodulatory Properties of Immune Checkpoint Inhibitors-More than Boosting T-Cell Responses?
  Cancers (Basel). 2022 Mar 28;14(7):1710. doi: 10.3390/cancers14071710. PMID: 35406483; PMCID: PMC8996886.
  
  
• Boedecker-Lips SC, Lautem A, Runkel S, Klimpke P, Kraus D, Keil P, Holtz S, Tomalla V, Marczynski P, Boedecker CD, Galle PR, Koch M, Weinmann-Menke J.
  Six-Month Follow-Up after Vaccination with BNT162b2: SARS-CoV-2 Antigen-Specific Cellular and Humoral Immune Responses in Hemodialysis Patients and Kidney Transplant Recipients. Pathogens. 2022 Jan 5;11(1):67.

2021

• Boedecker SC, Lüssi F., Kraus D., Klimpke P., Holtz S., Meinek M., Marczynski P, Weinmann A., Weinmann-Menke J. Immunoadsorption or plasma exchange – What is the best treatment option of neurological autoimmune diseases. J Clin Apher. 2021 Dec 14; doi: 10.1002/jca.21953. Online ahead of print.
  
  
• Engel S, Boedecker SC, Marczynski P, Bittner S, Steffen F, Weinmann A, Schwarting A, Zipp F, Weinmann-Menke, Luessi F. Association of serum neurofilament light chain levels and neuropsychiatric manifestations in systemic lupus erythematosus.Therapeutic Advances in Neurological Disorders. 2021 Oct 22;14:17562864211051497.
  
  
• Haist M, Stege H, Pemler S, Heinz J, Fleischer MI, Graf C, Ruf W, Loquai C, Grabbe S.
  Anticoagulation with Factor Xa Inhibitors Is Associated with Improved Overall Response and Progression-Free Survival in Patients with Metastatic Malignant Melanoma Receiving Immune Checkpoint Inhibitors-A Retrospective, Real-World Cohort Study. Cancers (Basel). 2021 Oct 12;13(20):5103. doi: 10.3390/cancers13205103.
  
  
• Stege H, Haist M, Nikfarjam U, Schultheis M, Heinz J, Pemler S, Loquai C, Grabbe S. The Status of Adjuvant and Neoadjuvant Melanoma Therapy, New Developments and Upcoming Challenges. Target Oncol. 2021 Sep;16(5):537-552. doi: 10.1007/s11523-021-00840-3. Epub 2021 Sep 23.
  
  
• Jung T, Haist M, Kuske M, Grabbe S, Bros M. Immunomodulatory Properties of BRAF and MEK Inhibitors Used for Melanoma Therapy-Paradoxical ERK Activation and Beyond. Int J Mol Sci. 2021 Sep 13;22(18):9890. doi: 10.3390/ijms22189890.
  
  
• Neuberger EWI, Brahmer A, Ehlert T, Kluge K, Philippi K, Boedecker SC, Weinmann-Menke J, Simon P. Validating quantitative PCR assays for cfDNA detection without DNA extraction in exercising SLE patients. Scientific Reports. 2021 Jun 30;11(1):13581.
  
  
• Legscha KJ, Antunes Ferreira E, Chamoun A, Lang A, Awwad MHS, Ton GNHQ, Galetzka D, Guezguez B, Hundemer M, Bourdon JC, Munder M, Theobald M, Echchannaoui H. Δ133p53α enhances metabolic and cellular fitness of TCR-engineered T cells and promotes superior antitumor immunity. J Immunother Cancer. 2021 Jun;9(6):e001846. doi: 10.1136/jitc-2020-001846. PMID: 34112738; PMCID: PMC8194333.
  
  
• Stege H, Haist M, Schultheis M, Fleischer MI, Mohr P, Meier F, Schadendorf D, Ugurel S, Livingstone E, Zimmer L, Herbst R, Pföhler C, Kähler K, Weichenthal M, Terheyden P, Nashan D, Debus D, Kaatz M, Ziller F, Haferkamp S, Forschner A, Leiter U, Kreuter A, Ulrich J, Kleemann J, Bradfisch F, Grabbe S, Loquai C. Discontinuation of BRAF/MEK-Directed Targeted Therapy after Complete Remission of Metastatic Melanoma-A Retrospective Multicenter ADOReg Study. Cancers (Basel). 2021 May 12;13(10):2312. doi: 10.3390/cancers13102312.
  
  
• Boedecker SC, Klimpke P, Kraus D, Runkel S, Galle PR, Koch M, Weinmann-Menke J.
  COVID-19-Importance for Patients on the Waiting List and after Kidney Transplantation-A Single Center Evaluation in 2020-2021.Pathogens. 2021 Apr 3;10(4):429.
  
  
• Piepgras J, Müller A, Steffen F, et al. Neurofilament light chain levels reflect outcome in a patient with GAD65-antibody positive autoimmune encephalitis under immune checkpoint inhibitor therapy. Eur J Neurol. 2021;28:1086–1089.
  
  
• Haist, M.; Stege, H.; Grabbe, S.; Bros, M. The Functional Crosstalk between Myeloid-Derived Suppressor Cells and Regulatory T Cells within the Immunosuppressive Tumor Microenvironment. Cancers. 2021, Jan 8. 13, 210.

2020

• Mayer, A.; Haist, M.; Loquai, C.; Grabbe, S.; Rapp, M.; Roth, W.; Vaupel, P.; Schmidberger, H. Role of Hypoxia and the Adenosine System in Immune Evasion and Prognosis of Patients with Brain Metastases of Melanoma: A Multiplex Whole Slide Immunofluorescence Study. Cancers 2020, 12, 3753. doi: 10.3390/cancers12123753