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AG Schuppan, Translationale Immunologie

  • Arbeitsgruppenleiter:in: Prof. Dr. Dr. Detlef Schuppan
  • Forschungsschwerpunkte:

    Research focus is on liver inflammation, fibrosis and NASH; on intestinal inflammation, food related disorders, including celiac disease, wheat sensitivity, food allergies and the role of the nutritional factors and the intestinal microbiome on autoimmunity, GI and liver cancer.
  • Fünf wichtigste Publikationen (2019-2020):

    1: Pickert G, Wirtz S, Matzner J, Ashfaq-Khan M, Heck R, Rosigkeit S, Thies D, Surabattula R, Ehmann D, Wehkamp J, Aslam M, He G, Weigert A, Foerster F, Klotz L, Frick JS, Becker C, Bockamp E, Schuppan D. Wheat Consumption Aggravates Colitis in Mice via Amylase Trypsin Inhibitor-mediated Dysbiosis. Gastroenterology 2020 Apr 3, in press.

    2: Verdu EF, Schuppan D. The enemy within the gut: bacterial pathogens in celiac autoimmunity. Nat Struct Mol Biol 2020;27:5-7.

    3: Ashfaq-Khan M, Aslam M, Qureshi MA, Senkowski MS, Yen-Weng S, Strand S, Kim YO, Pickert G, Schattenberg JM, Schuppan D. Dietary wheat amylase trypsin inhibitors promote features of murine non-alcoholic fatty liver disease. Sci Rep 2019;9:17463.

    4: Fritscher-Ravens A, Pflaum T, Mösinger M, Ruchay Z, Röcken C, Milla PJ, Das M, Böttner M, Wedel T, Schuppan D. Many Patients With Irritable Bowel Syndrome Have Atypical Food Allergies Not Associated With Immunoglobulin E. Gastroenterology 2019;157:109-118.e5.

    5: Schuppan D, Ashfaq-Khan M, Yang AT, Kim YO. Liver fibrosis: Direct antifibrotic agents and targeted therapies. Matrix Biol 2018;68-69:435-451.

 

 


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Ansprechpartnerin:

 

Sabine Tensing

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MAInz-DOC-Promotionskolleg

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