Juniorprofessur für Computergestützte Systemmedizin

Juniorprofessor Elisa Araldi, PhD, MS

Die Forschungsgruppe "Computergestützte Systemmedizin" ist in das CTH und in die Präventive Kardiologie und Medizinische Prävention (PKMP) der Klinik für Kardiologie integriert. Die Arbeitsgruppe verwendet systemmedizinische Ansätze, um klinische, genetische und phänotypische Exposomendaten mit Lipidomik-, Proteomik- und Metabolomikdaten zu integrieren, die aus standardisierten Massenspektrometrietechniken gewonnen wurden, um Herzinsuffizienz besser zu verstehen.

Forschungsschwerpunkte

• Systemmedizinische Analyse der klinischen und molekularen Heterogenität der Herzinsuffizienz
• Identifizierung neuer molekularer Marker von Herzinsuffizienz-Subtypen
• Vorhersage der Entwicklung einer Herzinsuffizienz mit einem systemmedizinischen Multi-Omics-Ansatz
• Charakterisierung metabolischer Signaturen bei Herzinsuffizienz mit Einzelzell-RNA-Sequenzierung

Kooperationspartner

• Prof. Dr. med Philipp Wild (CTH)
• Dr. med Jürgen Prochaska (CTH)
• Prof. Dr. rer. nat. Stefan Tenzer (Institut für Immunologie)
• Laura Bindila, PhD (Institut für Physiologische Chemie)

Nationale Partner

• Miguel Andreade, PhD (Johannes Gutenberg-Universität, Mainz)
• Univ.-Prof. Dr. Andreas Hildebrandt (Johannes Gutenberg-Universität, Mainz)
• Prof. Dr. Stefan Kramer (Johannes Gutenberg-Universität, Mainz)

Internationale Partner

• Prof. Anna Gloyn (Stanford University, USA)
• Prof. Michael Ristow (ETH Zurich, Schweiz, and Charite Berlin)
• Prof. Catherine Jutzeler (ETH Zurich, Schweiz)
• Prof. Betty Eipper (University of Connecticut, USA)
• Prof. Richard Mains (University of Connecticut, USA)
• Prof. Nils Bäck (University of Helsinki, Finnland)
• Prof. Yajaira Suarez (Yale University, USA)
• Prof. Carlos Fernandez-Hernando (Yale University, USA)
• Dr. Giampaolo Trivellin (Humanitas University, Italien)
• Prof. Alex Odermatt (University of Basel, Schweiz)
• Prof. Luca Colnaghi (San Raffaele University, Italien)

Drittmittelförderung

• DIASyM research core

Biographie - Elisa Araldi

Position:
Seit 2022 - Juniorprofessorin für Computergestütze Systemmedizin (W1, Tenure-Track), CTH, Universitätsmedizin der Johannes Gutenberg-Universität, Mainz

Wissenschaftlicher Werdegang:
2021 - 2022 - Senior PostDoc und Dozentin (bei Prof. M. Ristow), ETH Zürich, Schweiz
2016 - 2020 - PostDoc und Dozentin (bei Prof. M Stoffel), ETH Zürich, Schweiz
2015 - 2016 - PostDoc (bei Profs. Carlos Fernandez-Hernando and Yajaira Suarez), Yale University, USA 

Akademische Ausbildung:
2015 – PhD (bei Profs. Carlos Fernandez-Hernando and Yajaira Suarez), Pathobiologie und Translationale Medizin, New York University (USA)
2010 – Master in Molekularbiologie, Scuola Normale Superiore (Italien)
2009 – Master in Molekularbiologie, Universität Pisa (Italien)
2007 – Bachelor in Molekular- und Zellbiologie, Scuola Normale Superiore und Universität Pisa (Italien)

Researcher ID:
ORCID: 0000-0002-6596-6784
Scopus Author Identifier: 36056016400

Twitter:
Link (@ElisaAraldi)

Team - Juniorgruppe Computergestützte Systemmedizin

Sonstiges

Die Gruppe rekrutiert derzeit motivierte Doktoranden und Postdocs mit Fachkenntnissen in Molekular-/Zellbiologie, Biostatistik, Epidemiologie, Genetik, maschinellem Lernen für biomedizinische Wissenschaften und Einzelzell-RNA-Sequenzierung. Kontaktieren Sie  Elisa Araldi für weitere Informationen.

Ausgewählte Originalarbeiten

• Grigolon G, Araldi E, Erni R, Wu JY, Thomas C, La Fortezza M, Laube B, Pöhlmann D, Stoffel M, Zarse K, Carreira EM, Ristow M, Fischer F. Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan. Nat Commun. 2022 Jan 10;13(1):107
• Zhang X, McDonald JG, Aryal B, Canfrán-Duque A, Goldberg EL, Araldi E, Ding W, Fan Y, Thompson BM, Singh AK, Li Q, Tellides G, Ordovás-Montanes J, García Milian R, Dixit VD, Ikonen E, Suárez Y, Fernández-Hernando C. Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis. Proc Natl Acad Sci U S A. 2021 Nov 23;118(47):e2107682118
• Kobiita A, Godbersen S, Araldi E, Ghoshdastider U, Schmid MW, Spinas G, Moch H, Stoffel M. The Diabetes Gene JAZF1 Is Essential for the Homeostatic Control of Ribosome Biogenesis and Function in Metabolic Stress. Cell Rep. 2020 Jul 7;32(1):107846
• Araldi E, Fernández-Fuertes M, Canfrán-Duque A, Tang W, Cline GW, Madrigal-Matute J, Pober JS, Lasunción MA, Wu D, Fernández-Hernando C, Suárez Y. Lanosterol Modulates TLR4-Mediated Innate Immune Responses in Macrophages. Cell Rep. 2017 Jun 27;19(13):2743-2755
• Aryal B, Rotllan N, Araldi E, Ramírez CM, He S, Chousterman BG, Fenn AM, Wanschel A, Madrigal-Matute J, Warrier N, Martín-Ventura JL, Swirski FK, Suárez Y, Fernández-Hernando C. ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression. Nat Commun. 2016 Jul 27;7:12313
• Chamorro-Jorganes A, Araldi E, Penalva LO, Sandhu D, Fernández-Hernando C, Suárez Y. MicroRNA-16 and microRNA-424 regulate cell-autonomous angiogenic functions in endothelial cells via targeting vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1. Arterioscler Thromb Vasc Biol. 2011 Nov;31(11):2595-606

Weitere Originalarbeiten

• Zhang X, Rotllan N, Canfrán-Duque A, Sun J, Toczek J, Moshnikova A, Malik S, Price NL, Araldi E, Zhong W, Sadeghi MM, Andreev OA, Bahal R, Reshetnyak YK, Suárez Y, Fernández-Hernando C. Targeted Suppression of miRNA-33 Using pHLIP Improves Atherosclerosis Regression. Circ Res. 2022 Jun 24;131(1):77-90
• Price NL, Singh AK, Rotllan N, Goedeke L, Wing A, Canfrán-Duque A, Diaz-Ruiz A, Araldi E, Baldán Á, Camporez JP, Suárez Y, Rodeheffer MS, Shulman GI, de Cabo R, Fernández-Hernando C. Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance. Cell Rep. 2018 Feb 20;22(8):2133-2145
• Canfrán-Duque A, Rotllan N, Zhang X, Fernández-Fuertes M, Ramírez-Hidalgo C, Araldi E, Daimiel L, Busto R, Fernández-Hernando C, Suárez Y. Macrophage deficiency of miR-21 promotes apoptosis, plaque necrosis, and vascular inflammation during atherogenesis. EMBO Mol Med. 2017 Sep;9(9):1244-1262
• Montenont E, Echagarruga C, Allen N, Araldi E, Suarez Y, Berger JS. Platelet WDR1 suppresses platelet activity and is associated with cardiovascular disease. Blood. 2016 Oct 20;128(16):2033-2042
• Ulrich V, Rotllan N, Araldi E, Luciano A, Skroblin P, Abonnenc M, Perrotta P, Yin X, Bauer A, Leslie KL, Zhang P, Aryal B, Montgomery RL, Thum T, Martin K, Suarez Y, Mayr M, Fernandez-Hernando C, Sessa WC. Chronic miR-29 antagonism promotes favorable plaque remodeling in atherosclerotic mice. EMBO Mol Med. 2016 Jun 1;8(6):643-53
• Goedeke L, Rotllan N, Ramírez CM, Aranda JF, Canfrán-Duque A, Araldi E, Fernández-Hernando A, Langhi C, de Cabo R, Baldán Á, Suárez Y, Fernández-Hernando C. miR-27b inhibits LDLR and ABCA1 expression but does not influence plasma and hepatic lipid levels in mice. Atherosclerosis. 2015 Dec;243(2):499-509
• Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Sandusky G, Abadie J, Lyons KM, Giaccia AJ, Schipani E. Fibrosis and hypoxia-inducible factor-1α-dependent tumors of the soft tissue on loss of von Hippel-Lindau in mesenchymal progenitors. Am J Pathol. 2015 Nov;185(11):3090-101
• Goedeke L, Rotllan N, Canfrán-Duque A, Aranda JF, Ramírez CM, Araldi E, Lin CS, Anderson NN, Wagschal A, de Cabo R, Horton JD, Lasunción MA, Näär AM, Suárez Y, Fernández-Hernando C. MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels. Nat Med. 2015 Nov;21(11):1280-9
• Chamorro-Jorganes A, Lee MY, Araldi E, Landskroner-Eiger S, Fernández-Fuertes M, Sahraei M, Quiles Del Rey M, van Solingen C, Yu J, Fernández-Hernando C, Sessa WC, Suárez Y. VEGF-Induced Expression of miR-17-92 Cluster in Endothelial Cells Is Mediated by ERK/ELK1 Activation and Regulates Angiogenesis. Circ Res. 2016 Jan 8;118(1):38-47
• Rotllan N, Chamorro-Jorganes A, Araldi E, Wanschel AC, Aryal B, Aranda JF, Goedeke L, Salerno AG, Ramírez CM, Sessa WC, Suárez Y, Fernández-Hernando C. Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis. FASEB J. 2015 Feb;29(2):597-610
• Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Rankin EB, Giaccia AJ, Schipani E. Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development. Dev Biol. 2014 Sep 1;393(1):124-36
• van Solingen C, Araldi E, Chamorro-Jorganes A, Fernández-Hernando C, Suárez Y. Improved repair of dermal wounds in mice lacking microRNA-155. J Cell Mol Med. 2014 Jun;18(6):1104-12
• Chamorro-Jorganes A, Araldi E, Rotllan N, Cirera-Salinas D, Suárez Y. Autoregulation of glypican-1 by intronic microRNA-149 fine tunes the angiogenic response to FGF2 in human endothelial cells. J Cell Sci. 2014 Mar 15;127(Pt 6):1169-78
• Miller AM, Gilchrist DS, Nijjar J, Araldi E, Ramirez CM, Lavery CA, Fernández-Hernando C, McInnes IB, Kurowska-Stolarska M. MiR-155 has a protective role in the development of non-alcoholic hepatosteatosis in mice. PLoS One. 2013 Aug 21;8(8):e72324
• Ramírez CM, Rotllan N, Vlassov AV, Dávalos A, Li M, Goedeke L, Aranda JF, Cirera-Salinas D, Araldi E, Salerno A, Wanschel A, Zavadil J, Castrillo A, Kim J, Suárez Y, Fernández-Hernando C. Control of cholesterol metabolism and plasma high-density lipoprotein levels by microRNA-144. Circ Res. 2013 Jun 7;112(12):1592-601
• Lobry C, Ntziachristos P, Ndiaye-Lobry D, Oh P, Cimmino L, Zhu N, Araldi E, Hu W, Freund J, Abdel-Wahab O, Ibrahim S, Skokos D, Armstrong SA, Levine RL, Park CY, Aifantis I. Notch pathway activation targets AML-initiating cell homeostasis and differentiation. J Exp Med. 2013 Feb 11;210(2):301-19
• Rankin EB, Wu C, Khatri R, Wilson TL, Andersen R, Araldi E, Rankin AL, Yuan J, Kuo CJ, Schipani E, Giaccia AJ. The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO. Cell. 2012 Mar 30;149(1):63-74
• Maes C, Araldi E, Haigh K, Khatri R, Van Looveren R, Giaccia AJ, Haigh JJ, Carmeliet G, Schipani E. VEGF-independent cell-autonomous functions of HIF-1α regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival. J Bone Miner Res. 2012 Mar;27(3):596-609
• Klinakis A, Lobry C, Abdel-Wahab O, Oh P, Haeno H, Buonamici S, van De Walle I, Cathelin S, Trimarchi T, Araldi E, Liu C, Ibrahim S, Beran M, Zavadil J, Efstratiadis A, Taghon T, Michor F, Levine RL, Aifantis I. A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia. Nature. 2011 May 12;473(7346):230-3

Reviews

• Araldi E, Suárez Y. MicroRNAs as regulators of endothelial cell functions in cardiometabolic diseases. Biochim Biophys Acta. 2016 Dec;1861(12 Pt B):2094-2103
• Araldi E, Chamorro-Jorganes A, van Solingen C, Fernández-Hernando C, Suárez Y. Therapeutic Potential of Modulating microRNAs in Atherosclerotic Vascular Disease. Curr Vasc Pharmacol. 2013 May 13
• Chamorro-Jorganes A, Araldi E, Suárez Y. MicroRNAs as pharmacological targets in endothelial cell function and dysfunction. Pharmacol Res. 2013 Sep;75:15-27
• Araldi E, Schipani E. Hypoxia, HIFs and bone development. Bone. 2010 Aug;47(2):190-6

Kommentare

• Araldi E, Khatri R, Giaccia AJ, Simon MC, Schipani E. Lack of HIF-2α in limb bud mesenchyme causes a modest and transient delay of endochondral bone development. Nat Med. 2011 Jan;17(1):25-6; author reply 27-9
• Araldi E, Schipani E. MicroRNA-140 and the silencing of osteoarthritis. Genes Dev. 2010 Jun 1;24(11):1075-80